TWAS hub - LYSMD2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Putamen basal ganglia	0.1840	0.0800	9.0e-03	0.043	NA	-0.008	NA	0.015	3.5e-02	NA	5.5e-01	NA	1.4e-01
2	GTEx	Muscle Skeletal	0.2255	0.0548	8.3e-16	0.231	NA	0.198	NA	0.212	2.1e-22	NA	3.6e-19	NA	1.6e-20
3	YFS	Blood	0.0703	0.0321	1.7e-04	0.004	0.017	0.012	0.016	0.012	1.1e-02	1.6e-06	5.0e-05	3.4e-06	4.2e-05
4	TCGA	Stomach Adenocarcinoma	0.0620	0.0360	5.7e-03	0.007	0.011	-0.004	NA	-0.001	8.7e-02	5.2e-02	8.4e-01	NA	4.2e-01
5	TCGA	Uterine Corpus Endometrial Carcinoma	0.1720	0.1060	8.4e-03	0.060	0.023	0.045	NA	0.037	9.0e-03	7.6e-02	2.1e-02	NA	3.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Frequency of tiredness / lethargy in last 2 weeks	7.2	11.7	20.9	-1.2	4.6	1.5	4.1	-4.2
Ever had stillbirth, spontaneous miscarriage or termination	6.4	6.9	9.3	2.2	-2.7	-2.7	-2.3	3.0
Illnesses of father: None of the above (group 1)	6.0	7.4	13.6	0.1	-3.7	-2.1	-3.3	2.8
Chest pain or discomfort	5.4	7.8	18.0	-0.9	4.2	3.3	2.8	-1.1
Arm fat percentage (right)	4.3	16.8	38.6	-0.6	6.2	1.7	4.6	-4.6
Noisy workplace	4.2	5.2	10.9	1.0	3.3	2.1	2.6	-1.7
Smoking status: Previous	4.2	6.3	12.3	0.8	-3.3	0.8	-3.5	2.7
Past tobacco smoking	4.1	7.5	16.9	-0.5	3.8	0.1	4.1	-2.4
Arm fat mass (right)	4.1	16.7	33.7	-1.8	5.8	2.5	4.3	-4.7
Hearing difficulty/problems: Yes	4.0	6.1	13.2	0.2	3.6	2.8	2.9	-0.8
Arm fat mass (left)	3.8	15.8	32.0	-1.9	5.7	2.5	3.9	-4.6
BMI	3.7	21.3	43.8	-1.3	6.6	0.7	5.2	-5.8
Qualifications: nursing, teaching	3.7	5.7	12.0	-1.4	3.5	1.2	2.8	-2.2
Waist circumference	3.6	13.2	29.2	-1.1	5.4	2.4	3.4	-4.3
Body Mass Index (BMI) (2010)	3.5	4.8	9.2	2.1	2.6	0.1	1.9	-3.0
Arm fat percentage (left)	3.5	14.0	32.7	-0.6	5.7	1.3	4.0	-4.4
Family relationship satisfaction	3.4	4.2	9.7	-0.8	3.1	-0.5	2.0	-2.5
Weight	3.3	16.1	24.2	-3.2	4.9	3.6	3.6	-4.5
Hip circumference	3.2	13.6	21.9	-2.4	4.7	2.7	3.7	-4.4
Loud music exposure frequency	3.2	3.5	7.9	0.3	2.8	2.4	1.9	-0.4
Body mass index (BMI)	3.1	13.2	29.1	-0.5	5.4	1.3	4.0	-4.3
Whole body fat mass	2.8	11.7	21.2	-1.8	4.6	1.8	3.3	-4.5
Back pain experienced in last month	2.8	4.1	13.8	-0.3	2.5	3.7	0.9	0.1
Ever smoked	2.8	5.0	11.8	0.4	-3.4	-0.9	-3.3	1.2
Neck or shoulder pain in last month	2.7	3.8	10.6	1.3	3.2	2.2	0.7	1.2
Leg fat-free mass (right)	2.7	14.5	18.1	-4.1	4.0	4.2	2.9	-3.7
Leg predicted mass (right)	2.7	14.4	18.1	-4.1	4.0	4.3	2.9	-3.6
Basal metabolic rate	2.7	14.9	21.2	-3.9	4.0	4.6	2.8	-3.7
Leg fat-free mass (left)	2.6	13.8	18.0	-3.6	4.2	4.2	3.0	-3.4
Leg predicted mass (left)	2.6	14.0	18.4	-3.6	4.3	4.2	3.0	-3.4
Birth weight of first child	2.6	4.7	9.5	-3.1	2.7	0.7	1.2	-2.2
Diverticular disease/diverticulitis (self-reported)	2.5	2.9	5.3	-1.8	1.6	1.3	1.2	-2.3
Trunk fat mass	2.5	10.7	20.4	-1.9	4.2	1.7	2.9	-4.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	3.0	6.2	0.7	2.5	0.9	2.2	-1.6
Illnesses of father: High blood pressure	2.5	3.1	6.5	-0.4	2.5	0.9	2.3	-1.6
Hearing difficulty/problems with background noise	2.4	3.8	7.9	-0.6	2.8	2.5	2.1	0.4
Medication: Cholesterol lowering	2.4	3.7	8.9	0.7	-2.1	-0.1	-2.2	3.0
Illnesses of mother	2.4	3.0	10.7	-0.6	-1.0	3.3	-1.4	0.8
Body fat percentage	2.4	9.5	19.2	-0.4	4.3	0.5	3.0	-4.4
Number of children fathered	2.4	2.7	7.5	1.2	-0.7	1.0	-1.7	2.7
Leg fat mass (right)	2.4	9.3	19.2	-0.9	4.4	1.2	3.0	-4.0
Birth weight	2.3	5.0	7.4	-2.6	2.1	1.7	1.7	-2.7
Wheeze or whistling in the chest in last year	2.3	4.1	10.1	-0.6	3.2	1.8	1.9	-1.8
Whole body fat-free mass	2.3	12.9	22.5	-4.0	3.3	4.7	2.3	-3.0
Pain experienced in last month	2.3	3.8	14.3	-1.3	-3.8	-1.5	-0.8	0.6
Leg fat mass (left)	2.3	9.1	17.6	-1.1	4.2	1.2	2.9	-4.1
Trunk fat percentage	2.2	8.7	19.4	-1.0	3.9	0.4	2.7	-4.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	3.0	4.8	-0.9	2.1	2.2	1.7	-1.5
Trunk fat-free mass	2.2	12.9	27.8	-4.1	2.9	5.3	2.0	-2.6
Father’s age at death	2.2	3.0	6.8	0.7	0.1	-2.6	2.1	-1.9
Trunk predicted mass	2.2	12.6	27.9	-4.1	2.8	5.3	1.9	-2.5
Qualifications: College or University degree	2.2	7.0	12.7	-2.9	1.8	0.9	3.6	-3.2
Whole body water mass	2.2	12.7	22.4	-3.9	3.4	4.7	2.4	-3.0
Intelligence (Savage-Jansen 2018)	2.1	6.6	10.8	-2.7	2.8	0.1	3.3	-2.6
HDL Cholesterol	2.1	3.5	7.8	-0.8	1.9	2.8	2.2	-0.6
Smoking Status	2.1	5.1	12.1	-0.7	-2.8	-1.1	-3.5	1.8
High blood pressure (mother)	2.1	3.0	7.1	1.0	1.5	-1.5	2.7	-1.5
Time employed in main current job	2.1	2.4	3.6	1.5	-1.9	-0.7	-1.6	1.8
Comparative body size at age 10	2.1	5.8	13.5	-1.4	1.7	0.8	3.1	-3.7
Had major operations	2.1	2.5	5.4	0.8	1.2	2.2	-0.1	2.3
Knee pain experienced in last month	2.1	3.3	7.8	0.4	2.8	1.2	2.1	-1.5
High cholesterol (Self-reported)	2.1	3.8	7.9	-0.9	-2.8	-0.3	-1.7	2.7
Arm fat-free mass (left)	2.0	10.0	16.3	-3.0	3.3	4.0	2.3	-3.0
Average weekly beer plus cider intake	2.0	2.9	6.5	0.8	-2.4	-1.4	-2.5	-0.4
Age started oral contraceptive pill	2.0	2.4	6.4	1.2	2.0	-0.4	2.5	-0.2
Arm predicted mass (left)	2.0	10.0	16.9	-2.9	3.3	4.1	2.3	-2.9
Frequency of tenseness / restlessness in last 2 weeks	1.9	3.0	8.1	-0.4	1.5	2.8	1.7	-1.4
Major Depression (MDD)	1.8	2.2	6.4	-0.9	2.5	1.2	1.3	-0.9
Impedance of leg (left)	1.8	8.7	18.3	0.7	-4.3	-3.0	-3.7	1.5
Worrier / anxious feelings	1.8	3.4	5.4	-1.5	2.2	2.0	2.3	-0.7
Shortness of breath walking on level ground	1.8	2.1	5.0	-0.0	2.2	0.7	2.2	-0.6
Overall health rating	1.8	4.0	13.5	-0.4	3.7	0.9	1.4	-1.8
Diabetes diagnosed by doctor	1.8	2.9	7.4	0.5	2.7	0.7	1.7	-1.9
Medication: Co-codamol	1.7	2.0	4.6	0.1	1.8	2.1	1.5	-0.1
Stomach or abdominal pain in last month	1.7	2.1	5.4	1.8	2.3	0.2	0.6	-1.2
Sitting height	1.7	12.2	24.6	-5.0	-3.4	3.0	-3.4	2.0
Leg fat percentage (right)	1.7	6.2	13.5	1.1	3.7	-0.2	2.4	-3.2
Age at last live birth	1.7	2.5	5.6	-2.4	1.4	1.0	1.8	0.6
Leg fat percentage (left)	1.7	6.1	13.1	0.8	3.4	-0.1	2.2	-3.6
HbA1C	1.6	1.7	7.0	-2.6	0.0	-0.9	-0.8	-0.3
Impedance of leg (right)	1.6	7.8	13.1	1.6	-3.6	-2.9	-3.4	2.0
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	7.6	0.2	0.0	0.2	-1.2	2.8
Happiness	1.6	2.0	5.7	-0.7	1.7	-0.5	0.5	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	5.8	-0.8	2.4	1.4	1.2	-1.6
Eye problems/disorders: None of the above	1.6	1.8	4.4	-1.0	-2.1	-1.5	-1.1	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	4.6	-0.6	-1.9	-0.0	-0.9	2.2
Number of operations (self-reported)	1.6	2.4	6.6	-0.2	2.6	1.2	2.0	0.0
Breast Cancer	1.5	3.6	7.0	-2.3	1.3	0.7	1.9	-2.7
Type 2 Diabetes (T2D) (2018)	1.5	2.8	6.6	0.7	2.6	1.0	1.2	-2.1
Ever used hormone-replacement therapy (HRT)	1.5	1.9	6.3	1.3	-0.7	0.3	-1.1	2.5
Ever had hysterectomy (womb removed)	1.5	1.7	3.6	-0.8	1.9	1.8	0.8	-0.5
Number of incorrect matches in round	1.5	2.5	9.8	1.1	-0.8	0.6	-0.8	3.1
Had menopause	1.5	1.8	7.4	2.7	0.1	-0.5	0.6	1.1
Medication: Simvastatin	1.5	2.3	5.9	0.2	-2.4	0.1	-1.4	1.9
Forced vital capacity (FVC), Best measure	1.5	5.3	18.1	-4.3	-0.5	0.4	-1.2	-2.6
Supplements: Vitamin C	1.5	1.7	4.4	-1.1	0.7	0.3	2.1	-1.5
Illnesses of siblings: Diabetes	1.5	1.9	4.3	-0.9	1.7	0.6	1.0	-2.1
Medication: Lisinopril	1.5	1.9	3.6	-0.1	-0.9	1.6	-1.9	1.6
Basal cell carcinoma (self-reported)	1.5	1.8	2.9	-1.4	-1.2	0.6	-1.5	1.7
Depressed Affect (Nagel 2018)	1.4	2.9	10.9	-0.4	1.7	3.3	-0.2	-0.4
Neuroticism (Nagel 2018)	1.4	3.4	11.5	-1.0	2.0	3.4	0.5	0.1
Mean Putamen Volume	1.4	1.6	3.1	1.2	1.8	0.4	1.7	-0.7
Hand grip strength (left)	1.4	3.8	12.5	-3.5	-1.8	0.7	-0.2	-1.6
Standing height	1.4	13.9	38.9	-6.2	-0.5	5.4	-0.7	-0.8
Arm fat-free mass (right)	1.4	7.0	12.5	-3.4	2.0	3.5	1.0	-2.5
Pulse rate, automated reading	1.4	4.5	19.4	0.1	4.4	1.4	0.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	10.3	-3.2	0.1	1.9	-0.7	-0.5
Mood swings	1.4	2.5	6.7	-0.1	2.2	2.6	0.6	-0.5
Depression (Nagel 2018)	1.3	1.9	5.9	-0.6	1.4	2.4	1.0	-0.2
Schizophrenia vs Biploar Disorder	1.3	1.7	3.6	-0.9	0.1	1.5	-1.3	1.9
Height	1.3	25.1	64.8	-8.1	-0.4	7.7	-1.0	-0.6
Neuroticism score	1.3	2.6	7.8	-0.4	2.3	2.8	0.4	-0.1
Exposure to tobacco smoke at home	1.3	1.4	2.6	-1.6	0.5	-0.8	1.2	-1.4
Medication: Ventolin 100micrograms inhaler	1.3	1.7	4.6	0.0	1.6	0.7	1.0	-2.1
Arm predicted mass (right)	1.3	6.7	11.0	-3.2	2.1	3.3	1.1	-2.6
Long-standing illness, disability or infirmity	1.3	2.0	5.2	-0.2	2.3	1.8	1.0	-0.8
Friendships satisfaction	1.3	1.6	3.1	-0.5	1.8	-0.8	1.3	-1.5
Ever had prostate specific antigen (PSA) test	1.3	1.5	4.0	-0.7	0.2	1.8	0.2	2.0
Verbal and Numeric Reasoning (VNR)	1.2	2.9	4.6	-0.9	1.9	-1.0	2.1	-2.1
Neuroticism	1.2	3.0	9.6	-1.4	1.9	3.1	0.3	-0.0
Chronotype (morning person)	1.2	2.8	4.3	1.5	-1.9	-1.8	-2.1	-0.5
Sensitivity / hurt feelings	1.2	2.0	7.1	-1.5	0.1	2.7	-0.4	0.7
Forced vital capacity (FVC)	1.2	4.7	16.8	-4.1	-0.6	0.5	-1.7	-1.8
Diabetes (self-reported)	1.2	1.8	4.9	0.5	2.2	0.7	1.0	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	4.0	11.0	-3.3	-0.3	0.2	-0.7	-2.9
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.5	3.0	0.6	-1.3	-1.4	-1.7	0.2
Average weekly red wine intake	1.2	1.8	3.8	1.5	-1.1	-1.1	-0.7	1.9
Medication: Gliclazide	1.2	1.4	2.5	1.6	0.9	1.1	-0.5	1.5
Miserableness	1.2	2.1	8.6	0.3	1.4	2.9	0.0	-0.2
Guilty feelings	1.2	1.8	4.1	0.3	2.0	2.0	0.9	0.4
Medication: Metformin	1.1	1.5	4.4	1.0	2.1	0.6	1.3	-0.4
Fed-up feelings	1.1	1.9	3.2	0.1	1.4	1.8	-1.2	-1.7
Fluid intelligence score	1.1	2.2	4.1	-1.8	1.5	-0.6	1.2	-2.0
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.8	-1.7	-0.9	1.0	-1.2	1.0
Length of working week for main job	1.1	1.2	3.4	-0.7	-0.8	-0.7	-1.9	0.9
Peak expiratory flow (PEF)	1.1	2.5	8.8	-3.0	-1.0	-0.1	-0.9	-1.3
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.1	-1.5	1.8	0.7	1.1	-1.5
Medication for pain relief, constipation, heartburn	1.1	1.8	4.8	-0.2	-0.5	-2.2	0.7	-1.9
Heart disease (mother)	1.1	1.3	5.9	0.7	-0.1	-2.4	0.5	0.1
Alcohol intake frequency.	1.1	2.7	5.2	0.9	2.3	1.3	2.1	-1.1
Suffer from ‘nerves’	1.1	1.8	4.8	1.4	2.2	0.1	1.3	-0.7
Osteoarthritis (self-reported)	1.1	1.4	2.8	-0.7	1.7	0.4	1.5	-1.2
Number of self-reported non-cancer illnesses	1.1	1.9	7.4	2.7	0.5	-0.5	0.8	0.9
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	4.7	0.3	2.2	1.0	0.9	0.1
Supplements: Calcium	1.1	1.2	2.9	1.7	0.7	-0.3	1.5	0.3
Fasting Glucose	1.0	1.1	4.4	-2.1	0.2	0.2	-0.3	-1.1
Triglycerides	1.0	1.6	3.4	1.6	-1.0	-0.9	-1.8	0.6
Heel T-Score	1.0	7.7	16.4	-1.0	1.4	-3.9	4.0	-2.0
Lung FVC	1.0	5.2	11.1	-0.8	-2.4	-3.3	-2.9	-0.4
Had other major operations	1.0	1.2	2.4	-0.8	1.5	0.1	1.0	-1.4
Qualifications: None of the above	1.0	2.2	3.8	-0.9	-2.0	-0.5	-1.9	1.6
Pain all over the body in last month	1.0	1.1	2.3	-1.5	0.1	-0.8	-1.5	0.4
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	10.1	-3.2	-0.3	0.5	-1.1	-2.2
Hair/balding pattern: Pattern 4	1.0	2.5	6.9	0.7	2.6	1.1	1.6	-1.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	4.1	-0.1	0.3	2.0	1.3	0.0
Medication: Omeprazole	1.0	1.1	2.8	0.2	1.7	1.6	-0.1	0.7
Comparative height size at age 10	1.0	5.4	15.1	-3.9	0.9	3.0	1.2	-0.8
Number of full sisters	1.0	1.2	2.4	-1.1	-0.7	1.0	-1.5	-0.9
Leg pain on walking	1.0	1.2	2.4	1.4	1.6	0.5	1.1	-0.2
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.3	0.4	1.8	0.6	1.4	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.9	0.4	-1.7	0.4	-1.6	1.4
Impedance of whole body	1.0	5.2	10.3	0.3	-3.2	-2.2	-3.0	1.5
Prostate Cancer	0.9	1.3	2.7	0.6	1.0	1.6	1.6	0.2
Age at First Birth	0.9	1.2	2.7	0.0	0.5	1.6	1.6	-0.8
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.8	-0.2	1.1	2.0	0.9	-0.9
Relative age of first facial hair	0.9	1.9	4.4	-2.1	-1.1	-0.3	-1.5	1.4
Medication for hormone replacement therapy	0.9	1.0	2.2	-0.6	-1.1	-1.1	-1.5	0.6
Supplements: Zinc	0.9	0.9	3.0	-1.7	0.5	1.0	0.7	0.1
Average weekly fortified wine intake	0.9	1.0	4.7	-2.2	-0.4	-0.2	-0.0	-0.5
Taking other prescription medications	0.9	1.4	4.3	0.8	2.1	0.1	1.4	0.2
Illnesses of siblings	0.9	1.2	3.1	0.5	-1.0	-1.2	-0.4	1.8
Prospective memory result	0.9	1.1	2.2	1.2	-1.5	-1.1	-0.3	0.5
Health satisfaction	0.9	1.2	2.9	-0.3	1.4	-0.8	0.6	-1.7
Medication: Allopurinol	0.9	1.1	2.2	0.8	-1.3	-1.5	-0.3	1.1
Ever had bowel cancer screening	0.9	1.0	3.7	0.3	-0.5	0.4	-1.0	1.9
Eye problems/disorders: Cataract	0.9	1.0	2.7	0.2	1.6	0.5	1.2	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.5	-0.8	0.9	1.6	-0.7	0.9
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.7	0.4	-1.6	0.2	-1.1	1.1
Irritability	0.9	1.6	7.0	-0.8	0.4	2.6	0.1	-0.1
Alzheimer’s Disease (in father)	0.8	0.9	2.1	-0.1	1.4	-0.8	0.8	-1.0
Alzheimer’s Disease (including proxy)	0.8	1.2	2.2	0.0	1.5	-1.1	1.0	-1.3
Rheumatoid Arthritis	0.8	1.0	2.9	1.7	0.5	-0.8	1.1	0.5
Number of treatments/medications taken	0.8	1.5	3.2	1.8	0.1	0.7	-0.6	1.8
Average weekly spirits intake	0.8	1.0	2.9	-0.2	-1.3	-1.7	0.5	-0.1
Angina	0.8	1.1	3.5	0.3	1.9	1.0	0.8	0.3
Hand grip strength (right)	0.8	2.2	6.2	-2.5	-1.2	1.0	0.1	-1.6
Current tobacco smoking	0.8	1.3	3.0	-0.5	-0.6	-1.7	-1.5	0.8
Financial difficulties in last 2 years	0.8	1.1	2.5	0.4	1.6	0.9	1.3	-0.5
Heart attack	0.8	1.0	3.6	-0.2	-1.0	0.1	-0.4	1.9
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.1	-2.0	-0.5	-0.9	1.7	-1.0
Depression (self-reported)	0.8	0.9	2.2	0.8	1.5	0.2	1.1	-0.7
Pulse wave Arterial Stiffness index	0.8	0.9	1.8	-0.4	-0.8	0.7	-1.3	1.2
Tense / ‘highly strung’	0.8	1.3	2.2	0.1	1.3	1.5	1.5	-0.5
Medication: Amlodipine	0.8	1.1	2.3	0.8	1.5	0.2	1.5	-0.6
Pulse wave peak to peak time	0.8	0.9	2.0	0.0	0.7	-0.5	1.3	-1.4
Emphysema/chronic bronchitis	0.8	0.9	2.2	1.5	-0.0	-0.8	0.1	-1.3
Angina (self-reported)	0.8	1.0	3.4	0.4	1.8	0.9	0.8	0.1
Medication: Ibuprofen	0.8	0.9	1.7	-1.2	-0.3	0.7	-1.3	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.8	0.9	-0.1	0.5	-1.3	1.4
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.3	-1.5	-0.6	0.6	-1.2	0.8
Smoking status: Current	0.8	1.3	2.9	-0.5	-0.6	-1.7	-1.6	0.4
Average weekly champagne plus white wine intake	0.8	1.1	2.4	-1.1	0.6	1.6	1.2	-0.4
Neuroticism (2016)	0.7	1.0	2.3	-1.5	0.5	1.5	-0.1	-0.4
Diabetes (mother)	0.7	0.8	3.5	-0.5	1.9	0.7	0.1	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	2.6	-0.9	1.2	-1.6	1.1	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.1	-1.0	1.5	-1.2	1.5	-1.1
Mouth/teeth dental problems	0.7	1.1	4.8	0.7	-0.0	-2.2	0.1	0.2
Pulse rate	0.7	1.1	2.6	1.6	1.6	0.2	-0.1	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.2	0.4	-0.7	-1.1	-0.9	1.1
Mouth/teeth dental problems: Dentures	0.7	1.2	2.9	-0.9	-0.0	1.7	-0.9	1.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.7	-1.6	0.7	0.5	0.7	-0.2
Medication: Aspirin	0.7	0.9	2.7	-0.9	0.3	1.7	-0.1	1.0
Wears glasses or contact lenses	0.7	0.9	1.8	1.3	-1.3	-0.8	-0.4	-0.0
Hearing aid user	0.7	0.8	2.4	-1.1	-0.0	0.4	0.0	1.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.0	1.4	-0.4	-1.2	-0.7	0.3
Ever depressed for a whole week	0.7	0.8	2.6	-1.6	-0.5	-0.1	-1.1	0.4
Commuting to job workplace: Cycle	0.7	0.9	2.1	-0.9	-0.1	1.5	-1.1	-0.0
Alcohol drinker status: Previous	0.7	0.8	3.2	1.8	0.6	0.2	-0.1	0.6
Bipolar Disorder (2018)	0.6	1.0	2.7	-0.4	-0.6	-1.6	0.7	-1.1
Bipolar Disorder or Schizophrenia	0.6	1.4	3.1	-1.6	-0.2	-1.7	1.1	-0.3
Ulcerative Colitis (UC)	0.6	1.1	3.4	1.3	0.2	-1.8	0.5	-0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.4	-0.3	1.2	1.2	0.3	-1.1
Systolic blood pressure, automated reading	0.6	1.6	3.1	1.8	-0.9	-1.8	-0.9	0.5
Vitamin and mineral supplements	0.6	0.8	1.7	-0.3	0.1	-0.7	-1.3	1.3
Maternal smoking around birth	0.6	0.9	2.9	0.5	-0.2	0.6	-1.7	0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.0	-0.9	1.4	0.0	0.2	0.3
Qualifications: CSEs or equivalent	0.6	0.8	2.7	-0.2	1.6	-0.2	-0.3	-0.9
Alcohol usually taken with meals	0.6	1.0	2.4	-1.6	-0.7	-0.4	1.4	0.5
Medication: Ramipril	0.6	0.8	2.5	1.6	-0.2	-1.0	0.5	-0.2
Hair/balding pattern: Pattern 3	0.6	0.8	1.7	-1.1	0.5	1.3	-0.4	0.8
Medication: Lansoprazole	0.6	0.7	1.4	1.2	0.5	-1.0	0.8	-0.4
Lung cancer (father)	0.6	0.6	2.2	0.5	0.2	0.1	-1.5	0.9
Headache pain in last month	0.6	1.1	1.8	0.7	1.2	1.3	1.1	-0.9
Gout (self-reported)	0.6	0.9	2.0	1.1	-0.8	-1.4	0.5	0.6
Age at first live birth	0.6	1.0	2.8	-1.7	-0.8	0.3	0.3	1.2
Medication: Blood pressure	0.6	1.1	3.7	1.9	-0.9	-0.8	-0.2	0.6
Migraine (self-reported)	0.6	0.7	1.6	-1.3	-1.0	-0.4	-0.4	0.8
Mean time to correctly identify matches	0.6	1.2	3.0	1.3	1.7	-0.0	1.2	0.3
Illnesses of father: Heart disease	0.6	0.8	2.4	-0.8	0.8	1.6	-0.4	0.4
Commuting to job workplace: Walk	0.6	0.7	2.9	1.7	-0.4	0.1	-0.5	0.1
Breast cancer (self-reported)	0.6	0.7	3.3	-1.8	-0.3	-0.5	0.2	0.0
Medication: Atorvastatin	0.6	0.8	1.9	0.7	-0.1	-1.4	-0.4	1.1
Worry (Nagel 2018)	0.5	1.1	2.2	-0.0	1.5	1.5	1.0	0.4
Crohns Disease (2012)	0.5	0.8	1.4	-1.0	0.6	-0.9	1.2	-0.6
Ulcerative Colitis	0.5	0.7	2.7	-0.4	-0.6	-1.7	0.1	-0.3
Lung FEV1/FVC ratio	0.5	2.7	6.7	2.6	-1.2	-2.2	-0.2	-0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.3	0.3	1.5	-0.4	0.1	-0.4
Supplements: Glucosamine	0.5	0.6	1.7	0.3	0.8	-0.3	0.7	-1.3
Nervous feelings	0.5	0.9	3.1	1.8	0.7	-0.8	0.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.7	0.4	1.0	-0.2	1.6	-0.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.6	-0.7	0.2	0.7	0.9	-1.3
High blood pressure (siblings)	0.5	0.7	2.2	-1.5	-0.1	0.7	-0.3	-0.7
Number of full brothers	0.5	0.6	1.4	-1.1	0.7	-0.3	0.1	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.0	-0.5	1.0	1.0	-0.5	0.9
Loneliness, isolation	0.5	0.7	1.7	-0.7	1.3	0.6	0.5	-0.9
Mineral and other dietary supplements	0.5	0.7	1.5	-1.2	-0.3	0.8	-0.5	0.9
Medication: Aspirin	0.5	0.7	2.6	-0.4	0.2	1.6	0.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.3	0.5	-0.9	-1.8	-0.7	-1.0
Financial situation satisfaction	0.5	0.6	1.0	-0.7	-1.0	0.2	-0.7	0.9
Diastolic blood pressure, automated reading	0.5	1.7	4.1	1.1	-0.8	-2.0	-1.4	-0.7
Unable to work because of sickness or disability	0.5	0.6	1.1	-0.8	0.9	1.1	-0.7	0.1
Myopia	0.5	0.7	2.3	0.8	-0.7	-1.5	0.0	0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.5	-0.2	-0.8	0.2	-0.1	1.6
Heart disease (siblings)	0.5	0.7	1.3	0.9	-0.3	0.5	-1.0	-1.1
Schizophrenia (2018)	0.4	0.8	1.7	-1.3	0.2	-1.0	1.0	0.5
Irritable Bowel Disease (IBD)	0.4	0.9	2.6	-0.1	0.3	-1.6	1.0	-0.9
Bipolar Disorder (2011)	0.4	0.4	0.7	-0.0	-0.6	-0.8	-0.2	0.8
Lupus	0.4	0.6	1.3	0.1	0.9	0.9	1.1	0.3
Blood Eosinophil Count	0.4	3.1	4.7	1.1	2.1	-0.9	2.1	-2.2
Blood White Count	0.4	2.8	4.3	0.1	2.0	-2.1	1.2	-2.0
Waist Hip Ratio (WHR)	0.4	1.9	4.0	-0.0	1.6	2.0	-1.7	0.3
Diabetes (father)	0.4	0.5	1.7	-1.3	-0.1	-0.2	-0.0	-0.8
Severe depression (siblings)	0.4	0.4	1.1	-1.1	-0.1	0.5	0.7	-0.5
Pack years adult smoking proportion	0.4	0.6	1.3	-1.0	-0.6	-0.1	-0.6	-1.1
Relative age voice broke	0.4	0.6	0.9	-0.9	-0.9	-0.9	-0.3	0.9
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.3	-1.5	0.3	-0.1	0.5	-0.5
Number of live births	0.4	0.6	2.8	0.2	0.1	0.2	0.2	1.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.5	0.2	0.2	0.8	1.2	-1.2
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.3	-0.4	-0.2	-0.4	-0.9	1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.5	0.3	1.2	0.7	0.3	-0.1
Hypertension (Self-reported)	0.4	1.2	2.7	1.6	-0.4	-1.4	-1.1	0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.6	-0.1	1.3	0.9	0.0	-0.0
Medication: Bendroflumethiazide	0.4	0.6	2.3	0.9	-0.3	-1.5	-0.1	-0.0
Fractured/broken bones in last 5 years	0.4	0.5	1.1	0.8	-0.3	1.0	-0.3	0.9
Crohns Disease (2017)	0.3	0.7	1.2	-1.1	0.3	-0.9	0.8	-0.9
Coronary Artery Disease (CAD)	0.3	0.3	0.6	0.6	0.4	-0.8	0.6	0.3
LDL Cholesterol	0.3	0.5	1.2	-1.1	0.5	0.1	0.3	-1.0
Primary Biliary Cirrhosis	0.3	0.5	1.8	1.3	-0.3	-0.2	-0.5	0.4
Blood Platelet Count	0.3	3.1	10.3	-0.9	3.2	0.0	1.0	-1.8
Systolic Blood Pressure	0.3	1.7	2.2	1.4	-1.4	-1.4	-1.5	-0.3
Hypothyroidism (self reported)	0.3	0.8	2.1	0.4	0.4	0.8	0.9	-1.5
High blood pressure	0.3	0.8	1.9	1.2	-0.1	-1.4	-0.6	-0.4
Multivitamins +/- minerals	0.3	0.4	1.2	-0.2	-0.1	1.1	0.4	-0.9
Medication: Atenolol	0.3	0.4	0.6	0.6	-0.7	-0.5	0.7	-0.3
Medication: Levothyroxine sodium	0.3	0.5	1.9	0.0	-1.4	0.5	-0.4	-0.3
Chronic bronchitis/emphysema (father)	0.3	0.3	1.0	0.2	-0.0	1.0	-0.6	-0.3
Impedance of arm (left)	0.3	1.2	2.2	-0.4	-1.3	-1.0	-1.5	0.8
Glaucoma (self-reported)	0.3	0.4	1.2	1.1	-0.1	0.6	-0.7	-0.1
Exposure to tobacco smoke outside home	0.3	0.4	0.7	-0.7	0.6	0.8	0.3	-0.7
Osteoporosis (self-reported)	0.3	0.4	1.1	0.1	-0.7	0.1	-0.5	1.0
Ever taken oral contraceptive pill	0.3	0.3	1.3	0.0	-0.1	-0.3	-0.4	-1.1
Mother’s age at death	0.3	0.3	1.2	1.1	0.0	0.3	0.1	0.5
Commuting to job workplace: Public transport	0.3	0.4	1.5	-0.3	-0.5	-0.4	0.2	-1.2
Eye problems/disorders: Glaucoma	0.3	0.4	0.8	0.6	-0.7	0.9	-0.5	0.2
Medication: Blood pressure	0.3	0.6	1.2	1.1	0.7	0.3	0.5	-1.0
Alcohol drinker status: Never	0.3	0.4	1.6	-1.3	0.6	-0.1	0.1	-0.1
Cholesterol lowering medication	0.3	0.5	1.5	-0.1	-0.1	1.2	0.7	0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.3	-0.4	-0.3	0.1	-0.6	1.1
Reaction Time	0.2	0.4	1.9	0.1	1.4	0.2	0.3	-0.1
Schizophrenia (2014)	0.2	0.4	1.0	-0.9	0.0	-0.5	1.0	0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.0	-0.0	-0.5	0.3	-1.0	0.3
Allergy or Eczema	0.2	0.6	1.2	-1.1	1.0	0.2	0.1	0.8
Cardiovascular Disease	0.2	0.5	2.6	-0.2	0.0	-0.2	-1.6	-0.1
Respiratory disease	0.2	0.5	1.3	1.1	1.1	-0.2	0.2	-0.2
Tanning	0.2	3.0	6.8	0.5	-1.8	0.3	-2.6	2.1
Townsend deprivation index at recruitment	0.2	0.2	0.7	-0.4	0.3	0.8	-0.5	0.0
Serious illness, injury or assault to yourself	0.2	0.2	0.4	0.6	-0.7	-0.5	-0.2	0.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.0	-1.0	0.6	-0.5	0.7	-0.1
Hair/balding pattern: Pattern 2	0.2	0.3	0.9	0.2	0.5	-0.0	1.0	-0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	-0.6	0.2	0.0	-0.8	0.6
Falls in the last year	0.2	0.3	0.7	0.5	0.3	0.1	-0.7	0.8
Asthma	0.2	0.4	1.2	0.7	1.1	-0.0	0.5	-0.3
Breastfed as a baby	0.2	0.3	1.3	0.2	0.3	-0.2	1.1	0.2
Pulse wave reflection index	0.2	0.3	0.9	-1.0	-0.6	0.2	-0.0	0.3
Medication: Paracetamol	0.2	0.3	0.9	0.2	-0.1	0.7	-0.9	0.4
Worry too long after embarrassment	0.2	0.4	0.9	-0.4	0.7	0.9	0.5	0.2
Medication: Seretide 50 evohaler	0.2	0.3	1.1	0.1	0.2	1.1	0.2	0.4
Medication for cholesterol	0.2	0.3	0.6	-0.3	0.3	-0.3	0.7	-0.8
Asthma (self-reported)	0.2	0.4	1.4	0.8	1.2	0.0	0.3	-0.1
Risk taking	0.2	0.3	0.8	0.9	-0.7	0.0	0.2	0.3
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.8	-1.3	0.1	1.1	0.4	0.1
Pack years of smoking	0.2	0.3	0.6	-0.4	-0.8	0.1	-0.5	-0.6
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	0.2	0.5	-0.4	-0.3	0.2
Ovarian Cancer	0.1	0.1	0.3	-0.2	0.5	0.2	-0.2	0.4
Allergy	0.1	0.2	0.3	0.2	-0.5	0.6	-0.2	-0.4
Impedance of arm (right)	0.1	0.2	0.3	-0.6	-0.5	-0.2	-0.4	0.6
Alcohol intake versus 10 years previously	0.1	0.2	0.6	0.4	-0.2	-0.8	-0.4	-0.2
Blood clot in the leg (DVT)	0.1	0.2	0.5	-0.4	-0.2	0.2	-0.4	0.7
Medication: Paracetamol	0.1	0.2	0.5	0.5	0.4	-0.0	-0.7	0.1
Blood Red Count	0.0	0.2	0.4	0.3	0.4	-0.3	-0.4	0.6
Hair Pigment	0.0	0.9	2.1	1.5	-0.6	-1.4	-0.4	0.4
Age when periods started (menarche)	0.0	0.0	0.2	-0.4	0.1	-0.0	0.0	0.3

Hub : Genes

LYSMD2

Models

Trait associations