Hub : Genes

LYSMD2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Putamen basal ganglia 0.1840 0.0800 9.0e-03 0.043 NA -0.008 NA 0.015 3.5e-02 NA 5.5e-01 NA 1.4e-01
2 GTEx Muscle Skeletal 0.2255 0.0548 8.3e-16 0.231 NA 0.198 NA 0.212 2.1e-22 NA 3.6e-19 NA 1.6e-20
3 YFS Blood 0.0703 0.0321 1.7e-04 0.004 0.017 0.012 0.016 0.012 1.1e-02 1.6e-06 5.0e-05 3.4e-06 4.2e-05
4 TCGA Stomach Adenocarcinoma 0.0620 0.0360 5.7e-03 0.007 0.011 -0.004 NA -0.001 8.7e-02 5.2e-02 8.4e-01 NA 4.2e-01
5 TCGA Uterine Corpus Endometrial Carcinoma 0.1720 0.1060 8.4e-03 0.060 0.023 0.045 NA 0.037 9.0e-03 7.6e-02 2.1e-02 NA 3.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.6 1.0 2.7 -0.4 -0.6 -1.6 0.7 -1.1
Bipolar Disorder or Schizophrenia 0.6 1.4 3.1 -1.6 -0.2 -1.7 1.1 -0.3
Depressed Affect (Nagel 2018) 1.4 2.9 10.9 -0.4 1.7 3.3 -0.2 -0.4
Depression (Nagel 2018) 1.3 1.9 5.9 -0.6 1.4 2.4 1.0 -0.2
Intelligence (Savage-Jansen 2018) 2.1 6.6 10.8 -2.7 2.8 0.1 3.3 -2.6
Neuroticism (Nagel 2018) 1.4 3.4 11.5 -1.0 2.0 3.4 0.5 0.1
Schizophrenia (2018) 0.4 0.8 1.7 -1.3 0.2 -1.0 1.0 0.5
Schizophrenia vs Biploar Disorder 1.3 1.7 3.6 -0.9 0.1 1.5 -1.3 1.9
Worry (Nagel 2018) 0.5 1.1 2.2 -0.0 1.5 1.5 1.0 0.4
Alzheimer’s Disease (in mother) 0.1 0.1 0.3 0.2 0.5 -0.4 -0.3 0.2
Alzheimer’s Disease (in father) 0.8 0.9 2.1 -0.1 1.4 -0.8 0.8 -1.0
Alzheimer’s Disease (including proxy) 0.8 1.2 2.2 0.0 1.5 -1.1 1.0 -1.3
Crohns Disease (2017) 0.3 0.7 1.2 -1.1 0.3 -0.9 0.8 -0.9
Irritable Bowel Disease (IBD) 0.4 0.9 2.6 -0.1 0.3 -1.6 1.0 -0.9
Ulcerative Colitis (UC) 0.6 1.1 3.4 1.3 0.2 -1.8 0.5 -0.2
Major Depression (MDD) 1.8 2.2 6.4 -0.9 2.5 1.2 1.3 -0.9
Reaction Time 0.2 0.4 1.9 0.1 1.4 0.2 0.3 -0.1
Verbal and Numeric Reasoning (VNR) 1.2 2.9 4.6 -0.9 1.9 -1.0 2.1 -2.1
Breast Cancer 1.5 3.6 7.0 -2.3 1.3 0.7 1.9 -2.7
Ovarian Cancer 0.1 0.1 0.3 -0.2 0.5 0.2 -0.2 0.4
Prostate Cancer 0.9 1.3 2.7 0.6 1.0 1.6 1.6 0.2
Age at First Birth 0.9 1.2 2.7 0.0 0.5 1.6 1.6 -0.8
Bipolar Disorder (2011) 0.4 0.4 0.7 -0.0 -0.6 -0.8 -0.2 0.8
Body Mass Index (BMI) (2010) 3.5 4.8 9.2 2.1 2.6 0.1 1.9 -3.0
Coronary Artery Disease (CAD) 0.3 0.3 0.6 0.6 0.4 -0.8 0.6 0.3
Crohns Disease (2012) 0.5 0.8 1.4 -1.0 0.6 -0.9 1.2 -0.6
Mean Putamen Volume 1.4 1.6 3.1 1.2 1.8 0.4 1.7 -0.7
Fasting Glucose 1.0 1.1 4.4 -2.1 0.2 0.2 -0.3 -1.1
HbA1C 1.6 1.7 7.0 -2.6 0.0 -0.9 -0.8 -0.3
HDL Cholesterol 2.1 3.5 7.8 -0.8 1.9 2.8 2.2 -0.6
LDL Cholesterol 0.3 0.5 1.2 -1.1 0.5 0.1 0.3 -1.0
Lupus 0.4 0.6 1.3 0.1 0.9 0.9 1.1 0.3
Neuroticism (2016) 0.7 1.0 2.3 -1.5 0.5 1.5 -0.1 -0.4
Primary Biliary Cirrhosis 0.3 0.5 1.8 1.3 -0.3 -0.2 -0.5 0.4
Rheumatoid Arthritis 0.8 1.0 2.9 1.7 0.5 -0.8 1.1 0.5
Schizophrenia (2014) 0.2 0.4 1.0 -0.9 0.0 -0.5 1.0 0.3
Triglycerides 1.0 1.6 3.4 1.6 -1.0 -0.9 -1.8 0.6
Type 2 Diabetes (T2D) (2012) 0.2 0.3 1.0 -0.0 -0.5 0.3 -1.0 0.3
Ulcerative Colitis 0.5 0.7 2.7 -0.4 -0.6 -1.7 0.1 -0.3
Blood Eosinophil Count 0.4 3.1 4.7 1.1 2.1 -0.9 2.1 -2.2
Blood Platelet Count 0.3 3.1 10.3 -0.9 3.2 0.0 1.0 -1.8
Blood Red Count 0.0 0.2 0.4 0.3 0.4 -0.3 -0.4 0.6
Blood White Count 0.4 2.8 4.3 0.1 2.0 -2.1 1.2 -2.0
Heel T-Score 1.0 7.7 16.4 -1.0 1.4 -3.9 4.0 -2.0
BMI 3.7 21.3 43.8 -1.3 6.6 0.7 5.2 -5.8
Height 1.3 25.1 64.8 -8.1 -0.4 7.7 -1.0 -0.6
Waist Hip Ratio (WHR) 0.4 1.9 4.0 -0.0 1.6 2.0 -1.7 0.3
Systolic Blood Pressure 0.3 1.7 2.2 1.4 -1.4 -1.4 -1.5 -0.3
Smoking Status 2.1 5.1 12.1 -0.7 -2.8 -1.1 -3.5 1.8
Allergy or Eczema 0.2 0.6 1.2 -1.1 1.0 0.2 0.1 0.8
Cardiovascular Disease 0.2 0.5 2.6 -0.2 0.0 -0.2 -1.6 -0.1
Hypothyroidism (self reported) 0.3 0.8 2.1 0.4 0.4 0.8 0.9 -1.5
Respiratory disease 0.2 0.5 1.3 1.1 1.1 -0.2 0.2 -0.2
Type 2 Diabetes (T2D) (2018) 1.5 2.8 6.6 0.7 2.6 1.0 1.2 -2.1
Lung FEV1/FVC ratio 0.5 2.7 6.7 2.6 -1.2 -2.2 -0.2 -0.9
Lung FVC 1.0 5.2 11.1 -0.8 -2.4 -3.3 -2.9 -0.4
Neuroticism 1.2 3.0 9.6 -1.4 1.9 3.1 0.3 -0.0
Chronotype (morning person) 1.2 2.8 4.3 1.5 -1.9 -1.8 -2.1 -0.5
Hair Pigment 0.0 0.9 2.1 1.5 -0.6 -1.4 -0.4 0.4
Tanning 0.2 3.0 6.8 0.5 -1.8 0.3 -2.6 2.1
Hand grip strength (left) 1.4 3.8 12.5 -3.5 -1.8 0.7 -0.2 -1.6
Number of treatments/medications taken 0.8 1.5 3.2 1.8 0.1 0.7 -0.6 1.8
Average weekly spirits intake 0.8 1.0 2.9 -0.2 -1.3 -1.7 0.5 -0.1
Sensitivity / hurt feelings 1.2 2.0 7.1 -1.5 0.1 2.7 -0.4 0.7
Frequency of depressed mood in last 2 weeks 0.9 1.3 3.8 -0.2 1.1 2.0 0.9 -0.9
Hearing difficulty/problems: Yes 4.0 6.1 13.2 0.2 3.6 2.8 2.9 -0.8
Relative age of first facial hair 0.9 1.9 4.4 -2.1 -1.1 -0.3 -1.5 1.4
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.4 -0.3 1.2 1.2 0.3 -1.1
Ever used hormone-replacement therapy (HRT) 1.5 1.9 6.3 1.3 -0.7 0.3 -1.1 2.5
Ever had hysterectomy (womb removed) 1.5 1.7 3.6 -0.8 1.9 1.8 0.8 -0.5
Systolic blood pressure, automated reading 0.6 1.6 3.1 1.8 -0.9 -1.8 -0.9 0.5
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 2.3 0.3 1.5 -0.4 0.1 -0.4
Angina 0.8 1.1 3.5 0.3 1.9 1.0 0.8 0.3
Medication for hormone replacement therapy 0.9 1.0 2.2 -0.6 -1.1 -1.1 -1.5 0.6
Vitamin and mineral supplements 0.6 0.8 1.7 -0.3 0.1 -0.7 -1.3 1.3
Supplements: Zinc 0.9 0.9 3.0 -1.7 0.5 1.0 0.7 0.1
Medication: Co-codamol 1.7 2.0 4.6 0.1 1.8 2.1 1.5 -0.1
Medication: Metformin 1.1 1.5 4.4 1.0 2.1 0.6 1.3 -0.4
Diabetes (father) 0.4 0.5 1.7 -1.3 -0.1 -0.2 -0.0 -0.8
Diabetes (mother) 0.7 0.8 3.5 -0.5 1.9 0.7 0.1 0.0
Severe depression (siblings) 0.4 0.4 1.1 -1.1 -0.1 0.5 0.7 -0.5
Pack years adult smoking proportion 0.4 0.6 1.3 -1.0 -0.6 -0.1 -0.6 -1.1
Impedance of leg (right) 1.6 7.8 13.1 1.6 -3.6 -2.9 -3.4 2.0
Leg fat-free mass (left) 2.6 13.8 18.0 -3.6 4.2 4.2 3.0 -3.4
Trunk fat percentage 2.2 8.7 19.4 -1.0 3.9 0.4 2.7 -4.4
Hand grip strength (right) 0.8 2.2 6.2 -2.5 -1.2 1.0 0.1 -1.6
Townsend deprivation index at recruitment 0.2 0.2 0.7 -0.4 0.3 0.8 -0.5 0.0
Current tobacco smoking 0.8 1.3 3.0 -0.5 -0.6 -1.7 -1.5 0.8
Average weekly fortified wine intake 0.9 1.0 4.7 -2.2 -0.4 -0.2 -0.0 -0.5
Maternal smoking around birth 0.6 0.9 2.9 0.5 -0.2 0.6 -1.7 0.9
Fed-up feelings 1.1 1.9 3.2 0.1 1.4 1.8 -1.2 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 2.2 3.0 4.8 -0.9 2.1 2.2 1.7 -1.5
Relative age voice broke 0.4 0.6 0.9 -0.9 -0.9 -0.9 -0.3 0.9
Taking other prescription medications 0.9 1.4 4.3 0.8 2.1 0.1 1.4 0.2
Age when periods started (menarche) 0.0 0.0 0.2 -0.4 0.1 -0.0 0.0 0.3
Bilateral oophorectomy (both ovaries removed) 1.6 1.8 7.6 0.2 0.0 0.2 -1.2 2.8
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 2.6 -0.9 1.2 -1.6 1.1 -1.5
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 2.0 -0.9 1.4 0.0 0.2 0.3
Qualifications: CSEs or equivalent 0.6 0.8 2.7 -0.2 1.6 -0.2 -0.3 -0.9
Serious illness, injury or assault to yourself 0.2 0.2 0.4 0.6 -0.7 -0.5 -0.2 0.0
High blood pressure 0.3 0.8 1.9 1.2 -0.1 -1.4 -0.6 -0.4
Hayfever, allergic rhinitis or eczema 0.2 0.4 1.0 -1.0 0.6 -0.5 0.7 -0.1
Multivitamins +/- minerals 0.3 0.4 1.2 -0.2 -0.1 1.1 0.4 -0.9
Stomach or abdominal pain in last month 1.7 2.1 5.4 1.8 2.3 0.2 0.6 -1.2
Supplements: Glucosamine 0.5 0.6 1.7 0.3 0.8 -0.3 0.7 -1.3
Diverticular disease/diverticulitis (self-reported) 2.5 2.9 5.3 -1.8 1.6 1.3 1.2 -2.3
Medication: Atenolol 0.3 0.4 0.6 0.6 -0.7 -0.5 0.7 -0.3
Medication: Levothyroxine sodium 0.3 0.5 1.9 0.0 -1.4 0.5 -0.4 -0.3
Sitting height 1.7 12.2 24.6 -5.0 -3.4 3.0 -3.4 2.0
Chronic bronchitis/emphysema (father) 0.3 0.3 1.0 0.2 -0.0 1.0 -0.6 -0.3
High blood pressure (mother) 2.1 3.0 7.1 1.0 1.5 -1.5 2.7 -1.5
Body mass index (BMI) 3.1 13.2 29.1 -0.5 5.4 1.3 4.0 -4.3
Impedance of leg (left) 1.8 8.7 18.3 0.7 -4.3 -3.0 -3.7 1.5
Leg predicted mass (left) 2.6 14.0 18.4 -3.6 4.3 4.2 3.0 -3.4
Trunk fat mass 2.5 10.7 20.4 -1.9 4.2 1.7 2.9 -4.5
Waist circumference 3.6 13.2 29.2 -1.1 5.4 2.4 3.4 -4.3
Number of incorrect matches in round 1.5 2.5 9.8 1.1 -0.8 0.6 -0.8 3.1
Past tobacco smoking 4.1 7.5 16.9 -0.5 3.8 0.1 4.1 -2.4
Alcohol usually taken with meals 0.6 1.0 2.4 -1.6 -0.7 -0.4 1.4 0.5
Nervous feelings 0.5 0.9 3.1 1.8 0.7 -0.8 0.4 -0.1
Frequency of tenseness / restlessness in last 2 weeks 1.9 3.0 8.1 -0.4 1.5 2.8 1.7 -1.4
Hearing difficulty/problems with background noise 2.4 3.8 7.9 -0.6 2.8 2.5 2.1 0.4
Hair/balding pattern: Pattern 2 0.2 0.3 0.9 0.2 0.5 -0.0 1.0 -0.5
Had menopause 1.5 1.8 7.4 2.7 0.1 -0.5 0.6 1.1
Had other major operations 1.0 1.2 2.4 -0.8 1.5 0.1 1.0 -1.4
Forced vital capacity (FVC) 1.2 4.7 16.8 -4.1 -0.6 0.5 -1.7 -1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 2.1 -1.0 1.5 -1.2 1.5 -1.1
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.6 -0.6 0.2 0.0 -0.8 0.6
Qualifications: None of the above 1.0 2.2 3.8 -0.9 -2.0 -0.5 -1.9 1.6
Financial difficulties in last 2 years 0.8 1.1 2.5 0.4 1.6 0.9 1.3 -0.5
Mouth/teeth dental problems 0.7 1.1 4.8 0.7 -0.0 -2.2 0.1 0.2
Heart attack 0.8 1.0 3.6 -0.2 -1.0 0.1 -0.4 1.9
Allergy 0.1 0.2 0.3 0.2 -0.5 0.6 -0.2 -0.4
Pain all over the body in last month 1.0 1.1 2.3 -1.5 0.1 -0.8 -1.5 0.4
Diabetes (self-reported) 1.2 1.8 4.9 0.5 2.2 0.7 1.0 -1.6
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 2.3 -1.5 0.3 -0.1 0.5 -0.5
Medication: Ramipril 0.6 0.8 2.5 1.6 -0.2 -1.0 0.5 -0.2
Medication: Simvastatin 1.5 2.3 5.9 0.2 -2.4 0.1 -1.4 1.9
Fluid intelligence score 1.1 2.2 4.1 -1.8 1.5 -0.6 1.2 -2.0
Illnesses of siblings 0.9 1.2 3.1 0.5 -1.0 -1.2 -0.4 1.8
Neuroticism score 1.3 2.6 7.8 -0.4 2.3 2.8 0.4 -0.1
Weight 3.3 16.1 24.2 -3.2 4.9 3.6 3.6 -4.5
Impedance of arm (right) 0.1 0.2 0.3 -0.6 -0.5 -0.2 -0.4 0.6
Arm fat percentage (right) 4.3 16.8 38.6 -0.6 6.2 1.7 4.6 -4.6
Trunk fat-free mass 2.2 12.9 27.8 -4.1 2.9 5.3 2.0 -2.6
Hip circumference 3.2 13.6 21.9 -2.4 4.7 2.7 3.7 -4.4
Time employed in main current job 2.1 2.4 3.6 1.5 -1.9 -0.7 -1.6 1.8
Alcohol intake versus 10 years previously 0.1 0.2 0.6 0.4 -0.2 -0.8 -0.4 -0.2
Father’s age at death 2.2 3.0 6.8 0.7 0.1 -2.6 2.1 -1.9
Worrier / anxious feelings 1.8 3.4 5.4 -1.5 2.2 2.0 2.3 -0.7
Frequency of tiredness / lethargy in last 2 weeks 7.2 11.7 20.9 -1.2 4.6 1.5 4.1 -4.2
Falls in the last year 0.2 0.3 0.7 0.5 0.3 0.1 -0.7 0.8
Hair/balding pattern: Pattern 3 0.6 0.8 1.7 -1.1 0.5 1.3 -0.4 0.8
Number of live births 0.4 0.6 2.8 0.2 0.1 0.2 0.2 1.7
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 10.1 -3.2 -0.3 0.5 -1.1 -2.2
Pulse rate 0.7 1.1 2.6 1.6 1.6 0.2 -0.1 0.6
Happiness 1.6 2.0 5.7 -0.7 1.7 -0.5 0.5 -2.4
Noisy workplace 4.2 5.2 10.9 1.0 3.3 2.1 2.6 -1.7
Qualifications: A levels/AS levels or equivalent 0.8 1.8 4.1 -2.0 -0.5 -0.9 1.7 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.2 0.4 -0.7 -1.1 -0.9 1.1
Mouth/teeth dental problems: Dentures 0.7 1.2 2.9 -0.9 -0.0 1.7 -0.9 1.2
Asthma 0.2 0.4 1.2 0.7 1.1 -0.0 0.5 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.8 -1.7 -0.9 1.0 -1.2 1.0
Medication: Cholesterol lowering 2.4 3.7 8.9 0.7 -2.1 -0.1 -2.2 3.0
Depression (self-reported) 0.8 0.9 2.2 0.8 1.5 0.2 1.1 -0.7
Medication: Lansoprazole 0.6 0.7 1.4 1.2 0.5 -1.0 0.8 -0.4
Prospective memory result 0.9 1.1 2.2 1.2 -1.5 -1.1 -0.3 0.5
Lung cancer (father) 0.6 0.6 2.2 0.5 0.2 0.1 -1.5 0.9
Illnesses of mother 2.4 3.0 10.7 -0.6 -1.0 3.3 -1.4 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 4.0 11.0 -3.3 -0.3 0.2 -0.7 -2.9
Pulse wave Arterial Stiffness index 0.8 0.9 1.8 -0.4 -0.8 0.7 -1.3 1.2
Impedance of arm (left) 0.3 1.2 2.2 -0.4 -1.3 -1.0 -1.5 0.8
Arm fat mass (right) 4.1 16.7 33.7 -1.8 5.8 2.5 4.3 -4.7
Trunk predicted mass 2.2 12.6 27.9 -4.1 2.8 5.3 1.9 -2.5
Standing height 1.4 13.9 38.9 -6.2 -0.5 5.4 -0.7 -0.8
Length of working week for main job 1.1 1.2 3.4 -0.7 -0.8 -0.7 -1.9 0.9
Exposure to tobacco smoke at home 1.3 1.4 2.6 -1.6 0.5 -0.8 1.2 -1.4
Breastfed as a baby 0.2 0.3 1.3 0.2 0.3 -0.2 1.1 0.2
Tense / ‘highly strung’ 0.8 1.3 2.2 0.1 1.3 1.5 1.5 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.5 5.8 -0.8 2.4 1.4 1.2 -1.6
Hair/balding pattern: Pattern 4 1.0 2.5 6.9 0.7 2.6 1.1 1.6 -1.1
Birth weight of first child 2.6 4.7 9.5 -3.1 2.7 0.7 1.2 -2.2
Peak expiratory flow (PEF) 1.1 2.5 8.8 -3.0 -1.0 -0.1 -0.9 -1.3
Pulse wave reflection index 0.2 0.3 0.9 -1.0 -0.6 0.2 -0.0 0.3
Ever highly irritable/argumentative for 2 days 1.0 1.2 4.1 -0.1 0.3 2.0 1.3 0.0
Loud music exposure frequency 3.2 3.5 7.9 0.3 2.8 2.4 1.9 -0.4
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.7 0.4 1.0 -0.2 1.6 -0.4
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.6 -0.7 0.2 0.7 0.9 -1.3
Blood clot in the leg (DVT) 0.1 0.2 0.5 -0.4 -0.2 0.2 -0.4 0.7
Medication: Paracetamol 0.2 0.3 0.9 0.2 -0.1 0.7 -0.9 0.4
Headache pain in last month 0.6 1.1 1.8 0.7 1.2 1.3 1.1 -0.9
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 3.1 -1.5 1.8 0.7 1.1 -1.5
Glaucoma (self-reported) 0.3 0.4 1.2 1.1 -0.1 0.6 -0.7 -0.1
Gout (self-reported) 0.6 0.9 2.0 1.1 -0.8 -1.4 0.5 0.6
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 1.5 0.2 0.2 0.8 1.2 -1.2
Medication: Amlodipine 0.8 1.1 2.3 0.8 1.5 0.2 1.5 -0.6
Medication: Ventolin 100micrograms inhaler 1.3 1.7 4.6 0.0 1.6 0.7 1.0 -2.1
Birth weight 2.3 5.0 7.4 -2.6 2.1 1.7 1.7 -2.7
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.3 -0.4 -0.2 -0.4 -0.9 1.2
High blood pressure (siblings) 0.5 0.7 2.2 -1.5 -0.1 0.7 -0.3 -0.7
Forced vital capacity (FVC), Best measure 1.5 5.3 18.1 -4.3 -0.5 0.4 -1.2 -2.6
Body fat percentage 2.4 9.5 19.2 -0.4 4.3 0.5 3.0 -4.4
Leg fat percentage (right) 1.7 6.2 13.5 1.1 3.7 -0.2 2.4 -3.2
Arm fat-free mass (right) 1.4 7.0 12.5 -3.4 2.0 3.5 1.0 -2.5
Exposure to tobacco smoke outside home 0.3 0.4 0.7 -0.7 0.6 0.8 0.3 -0.7
Comparative body size at age 10 2.1 5.8 13.5 -1.4 1.7 0.8 3.1 -3.7
Number of full brothers 0.5 0.6 1.4 -1.1 0.7 -0.3 0.1 -1.2
Worry too long after embarrassment 0.2 0.4 0.9 -0.4 0.7 0.9 0.5 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.0 -0.5 1.0 1.0 -0.5 0.9
Wheeze or whistling in the chest in last year 2.3 4.1 10.1 -0.6 3.2 1.8 1.9 -1.8
Number of children fathered 2.4 2.7 7.5 1.2 -0.7 1.0 -1.7 2.7
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.5 3.0 0.6 -1.3 -1.4 -1.7 0.2
Age at first live birth 0.6 1.0 2.8 -1.7 -0.8 0.3 0.3 1.2
Pulse wave peak to peak time 0.8 0.9 2.0 0.0 0.7 -0.5 1.3 -1.4
Health satisfaction 0.9 1.2 2.9 -0.3 1.4 -0.8 0.6 -1.7
Shortness of breath walking on level ground 1.8 2.1 5.0 -0.0 2.2 0.7 2.2 -0.6
Qualifications: College or University degree 2.2 7.0 12.7 -2.9 1.8 0.9 3.6 -3.2
Eye problems/disorders: None of the above 1.6 1.8 4.4 -1.0 -2.1 -1.5 -1.1 0.4
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.5 0.3 1.2 0.7 0.3 -0.1
Emphysema/chronic bronchitis 0.8 0.9 2.2 1.5 -0.0 -0.8 0.1 -1.3
Medication for pain relief, constipation, heartburn 1.1 1.8 4.8 -0.2 -0.5 -2.2 0.7 -1.9
Neck or shoulder pain in last month 2.7 3.8 10.6 1.3 3.2 2.2 0.7 1.2
Medication: Blood pressure 0.6 1.1 3.7 1.9 -0.9 -0.8 -0.2 0.6
Angina (self-reported) 0.8 1.0 3.4 0.4 1.8 0.9 0.8 0.1
Migraine (self-reported) 0.6 0.7 1.6 -1.3 -1.0 -0.4 -0.4 0.8
Medication: Ibuprofen 0.8 0.9 1.7 -1.2 -0.3 0.7 -1.3 0.9
Medication: Allopurinol 0.9 1.1 2.2 0.8 -1.3 -1.5 -0.3 1.1
Medication: Omeprazole 1.0 1.1 2.8 0.2 1.7 1.6 -0.1 0.7
Medication: Seretide 50 evohaler 0.2 0.3 1.1 0.1 0.2 1.1 0.2 0.4
Mean time to correctly identify matches 0.6 1.2 3.0 1.3 1.7 -0.0 1.2 0.3
Heart disease (mother) 1.1 1.3 5.9 0.7 -0.1 -2.4 0.5 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 4.6 -0.6 -1.9 -0.0 -0.9 2.2
Whole body fat mass 2.8 11.7 21.2 -1.8 4.6 1.8 3.3 -4.5
Leg fat mass (right) 2.4 9.3 19.2 -0.9 4.4 1.2 3.0 -4.0
Arm predicted mass (right) 1.3 6.7 11.0 -3.2 2.1 3.3 1.1 -2.6
Pulse rate, automated reading 1.4 4.5 19.4 0.1 4.4 1.4 0.4 -1.1
Alcohol intake frequency. 1.1 2.7 5.2 0.9 2.3 1.3 2.1 -1.1
Comparative height size at age 10 1.0 5.4 15.1 -3.9 0.9 3.0 1.2 -0.8
Number of full sisters 1.0 1.2 2.4 -1.1 -0.7 1.0 -1.5 -0.9
Suffer from ‘nerves’ 1.1 1.8 4.8 1.4 2.2 0.1 1.3 -0.7
Overall health rating 1.8 4.0 13.5 -0.4 3.7 0.9 1.4 -1.8
Chest pain or discomfort 5.4 7.8 18.0 -0.9 4.2 3.3 2.8 -1.1
Had major operations 2.1 2.5 5.4 0.8 1.2 2.2 -0.1 2.3
Age at last live birth 1.7 2.5 5.6 -2.4 1.4 1.0 1.8 0.6
Family relationship satisfaction 3.4 4.2 9.7 -0.8 3.1 -0.5 2.0 -2.5
Leg pain on walking 1.0 1.2 2.4 1.4 1.6 0.5 1.1 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 1.8 0.9 -0.1 0.5 -1.3 1.4
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.7 -1.6 0.7 0.5 0.7 -0.2
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.3 -1.5 -0.6 0.6 -1.2 0.8
Medication: Aspirin 0.7 0.9 2.7 -0.9 0.3 1.7 -0.1 1.0
Supplements: Vitamin C 1.5 1.7 4.4 -1.1 0.7 0.3 2.1 -1.5
Knee pain experienced in last month 2.1 3.3 7.8 0.4 2.8 1.2 2.1 -1.5
Hypertension (Self-reported) 0.4 1.2 2.7 1.6 -0.4 -1.4 -1.1 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.5 3.0 6.2 0.7 2.5 0.9 2.2 -1.6
Illnesses of father: Heart disease 0.6 0.8 2.4 -0.8 0.8 1.6 -0.4 0.4
Illnesses of siblings: Diabetes 1.5 1.9 4.3 -0.9 1.7 0.6 1.0 -2.1
Smoking status: Previous 4.2 6.3 12.3 0.8 -3.3 0.8 -3.5 2.7
Forced expiratory volume in 1-second (FEV1), predicted 1.4 2.9 10.3 -3.2 0.1 1.9 -0.7 -0.5
Whole body fat-free mass 2.3 12.9 22.5 -4.0 3.3 4.7 2.3 -3.0
Leg fat-free mass (right) 2.7 14.5 18.1 -4.1 4.0 4.2 2.9 -3.7
Arm fat percentage (left) 3.5 14.0 32.7 -0.6 5.7 1.3 4.0 -4.4
Average weekly red wine intake 1.2 1.8 3.8 1.5 -1.1 -1.1 -0.7 1.9
Handedness (chirality/laterality): Left-handed 1.0 1.2 3.3 0.4 1.8 0.6 1.4 -0.5
Mood swings 1.4 2.5 6.7 -0.1 2.2 2.6 0.6 -0.5
Loneliness, isolation 0.5 0.7 1.7 -0.7 1.3 0.6 0.5 -0.9
Long-standing illness, disability or infirmity 1.3 2.0 5.2 -0.2 2.3 1.8 1.0 -0.8
Ever had bowel cancer screening 0.9 1.0 3.7 0.3 -0.5 0.4 -1.0 1.9
Diabetes diagnosed by doctor 1.8 2.9 7.4 0.5 2.7 0.7 1.7 -1.9
Ever had stillbirth, spontaneous miscarriage or termination 6.4 6.9 9.3 2.2 -2.7 -2.7 -2.3 3.0
Friendships satisfaction 1.3 1.6 3.1 -0.5 1.8 -0.8 1.3 -1.5
Qualifications: nursing, teaching 3.7 5.7 12.0 -1.4 3.5 1.2 2.8 -2.2
Commuting to job workplace: Walk 0.6 0.7 2.9 1.7 -0.4 0.1 -0.5 0.1
Eye problems/disorders: Cataract 0.9 1.0 2.7 0.2 1.6 0.5 1.2 -0.7
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 2.9 0.4 -1.7 0.4 -1.6 1.4
Medication for cholesterol 0.2 0.3 0.6 -0.3 0.3 -0.3 0.7 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 2.5 -0.8 0.9 1.6 -0.7 0.9
Back pain experienced in last month 2.8 4.1 13.8 -0.3 2.5 3.7 0.9 0.1
Mineral and other dietary supplements 0.5 0.7 1.5 -1.2 -0.3 0.8 -0.5 0.9
Breast cancer (self-reported) 0.6 0.7 3.3 -1.8 -0.3 -0.5 0.2 0.0
Asthma (self-reported) 0.2 0.4 1.4 0.8 1.2 0.0 0.3 -0.1
Osteoporosis (self-reported) 0.3 0.4 1.1 0.1 -0.7 0.1 -0.5 1.0
Osteoarthritis (self-reported) 1.1 1.4 2.8 -0.7 1.7 0.4 1.5 -1.2
Medication: Aspirin 0.5 0.7 2.6 -0.4 0.2 1.6 0.3 0.8
Medication: Gliclazide 1.2 1.4 2.5 1.6 0.9 1.1 -0.5 1.5
Illnesses of father: None of the above (group 1) 6.0 7.4 13.6 0.1 -3.7 -2.1 -3.3 2.8
Smoking status: Current 0.8 1.3 2.9 -0.5 -0.6 -1.7 -1.6 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 3.3 0.5 -0.9 -1.8 -0.7 -1.0
Whole body water mass 2.2 12.7 22.4 -3.9 3.4 4.7 2.4 -3.0
Leg predicted mass (right) 2.7 14.4 18.1 -4.1 4.0 4.3 2.9 -3.6
Arm fat mass (left) 3.8 15.8 32.0 -1.9 5.7 2.5 3.9 -4.6
Number of self-reported non-cancer illnesses 1.1 1.9 7.4 2.7 0.5 -0.5 0.8 0.9
Average weekly champagne plus white wine intake 0.8 1.1 2.4 -1.1 0.6 1.6 1.2 -0.4
Miserableness 1.2 2.1 8.6 0.3 1.4 2.9 0.0 -0.2
Guilty feelings 1.2 1.8 4.1 0.3 2.0 2.0 0.9 0.4
Wears glasses or contact lenses 0.7 0.9 1.8 1.3 -1.3 -0.8 -0.4 -0.0
Ever taken oral contraceptive pill 0.3 0.3 1.3 0.0 -0.1 -0.3 -0.4 -1.1
Hearing aid user 0.7 0.8 2.4 -1.1 -0.0 0.4 0.0 1.5
Mother’s age at death 0.3 0.3 1.2 1.1 0.0 0.3 0.1 0.5
Financial situation satisfaction 0.5 0.6 1.0 -0.7 -1.0 0.2 -0.7 0.9
Tinnitus: Yes, now most or all of the time 0.9 1.0 2.7 0.4 -1.6 0.2 -1.1 1.1
Commuting to job workplace: Public transport 0.3 0.4 1.5 -0.3 -0.5 -0.4 0.2 -1.2
Eye problems/disorders: Glaucoma 0.3 0.4 0.8 0.6 -0.7 0.9 -0.5 0.2
Medication: Blood pressure 0.3 0.6 1.2 1.1 0.7 0.3 0.5 -1.0
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.6 -0.1 1.3 0.9 0.0 -0.0
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.0 1.4 -0.4 -1.2 -0.7 0.3
High cholesterol (Self-reported) 2.1 3.8 7.9 -0.9 -2.8 -0.3 -1.7 2.7
Medication: Bendroflumethiazide 0.4 0.6 2.3 0.9 -0.3 -1.5 -0.1 -0.0
Medication: Paracetamol 0.1 0.2 0.5 0.5 0.4 -0.0 -0.7 0.1
Medication: Lisinopril 1.5 1.9 3.6 -0.1 -0.9 1.6 -1.9 1.6
Medication: Atorvastatin 0.6 0.8 1.9 0.7 -0.1 -1.4 -0.4 1.1
Illnesses of father: High blood pressure 2.5 3.1 6.5 -0.4 2.5 0.9 2.3 -1.6
Alcohol drinker status: Never 0.3 0.4 1.6 -1.3 0.6 -0.1 0.1 -0.1
Ever smoked 2.8 5.0 11.8 0.4 -3.4 -0.9 -3.3 1.2
Basal metabolic rate 2.7 14.9 21.2 -3.9 4.0 4.6 2.8 -3.7
Leg fat percentage (left) 1.7 6.1 13.1 0.8 3.4 -0.1 2.2 -3.6
Arm fat-free mass (left) 2.0 10.0 16.3 -3.0 3.3 4.0 2.3 -3.0
Number of operations (self-reported) 1.6 2.4 6.6 -0.2 2.6 1.2 2.0 0.0
Average weekly beer plus cider intake 2.0 2.9 6.5 0.8 -2.4 -1.4 -2.5 -0.4
Irritability 0.9 1.6 7.0 -0.8 0.4 2.6 0.1 -0.1
Risk taking 0.2 0.3 0.8 0.9 -0.7 0.0 0.2 0.3
Ever had prostate specific antigen (PSA) test 1.3 1.5 4.0 -0.7 0.2 1.8 0.2 2.0
Fractured/broken bones in last 5 years 0.4 0.5 1.1 0.8 -0.3 1.0 -0.3 0.9
Age started oral contraceptive pill 2.0 2.4 6.4 1.2 2.0 -0.4 2.5 -0.2
Diastolic blood pressure, automated reading 0.5 1.7 4.1 1.1 -0.8 -2.0 -1.4 -0.7
Ever depressed for a whole week 0.7 0.8 2.6 -1.6 -0.5 -0.1 -1.1 0.4
Unable to work because of sickness or disability 0.5 0.6 1.1 -0.8 0.9 1.1 -0.7 0.1
Commuting to job workplace: Cycle 0.7 0.9 2.1 -0.9 -0.1 1.5 -1.1 -0.0
Myopia 0.5 0.7 2.3 0.8 -0.7 -1.5 0.0 0.3
Vascular/heart problems diagnosed by doctor 0.2 0.7 1.8 -1.3 0.1 1.1 0.4 0.1
Cholesterol lowering medication 0.3 0.5 1.5 -0.1 -0.1 1.2 0.7 0.6
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 4.7 0.3 2.2 1.0 0.9 0.1
Pain experienced in last month 2.3 3.8 14.3 -1.3 -3.8 -1.5 -0.8 0.6
Supplements: Calcium 1.1 1.2 2.9 1.7 0.7 -0.3 1.5 0.3
Basal cell carcinoma (self-reported) 1.5 1.8 2.9 -1.4 -1.2 0.6 -1.5 1.7
Heart attack/myocardial infarction (self-reported) 0.5 0.6 2.5 -0.2 -0.8 0.2 -0.1 1.6
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.3 -0.4 -0.3 0.1 -0.6 1.1
Heart disease (siblings) 0.5 0.7 1.3 0.9 -0.3 0.5 -1.0 -1.1
Alcohol drinker status: Previous 0.7 0.8 3.2 1.8 0.6 0.2 -0.1 0.6
Pack years of smoking 0.2 0.3 0.6 -0.4 -0.8 0.1 -0.5 -0.6
Impedance of whole body 1.0 5.2 10.3 0.3 -3.2 -2.2 -3.0 1.5
Leg fat mass (left) 2.3 9.1 17.6 -1.1 4.2 1.2 2.9 -4.1
Arm predicted mass (left) 2.0 10.0 16.9 -2.9 3.3 4.1 2.3 -2.9