Best TWAS P=3.39e-24 · Best GWAS P=1.11e-21 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MYO9A | 0.06 | 0.03 | lasso | 2 | 0.01 | 4.7e-02 | 7.7 | -7.7 | 9.4e-15 | -0.20 | 0.34 | 0.15 | FALSE |
| 2 | GTEx | Artery Tibial | MYO9A | 0.07 | 0.08 | enet | 11 | 0.09 | 2.5e-07 | 7.8 | -7.3 | 3.6e-13 | -0.13 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Brain Cerebellum | MYO9A | 0.18 | 0.12 | lasso | 2 | 0.06 | 6.3e-03 | 5.9 | -5.9 | 2.9e-09 | -0.14 | 0.11 | 0.11 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | MYO9A | 0.19 | 0.02 | lasso | 8 | 0.03 | 9.4e-03 | 7.7 | -10.1 | 3.4e-24 | -0.56 | 0.05 | 0.86 | TRUE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | MYO9A | 0.13 | 0.08 | lasso | 3 | 0.08 | 1.7e-03 | 7.5 | -7.2 | 5.8e-13 | -0.15 | 0.63 | 0.02 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | MYO9A | 0.06 | 0.04 | lasso | 5 | 0.03 | 3.8e-03 | 5.2 | -5.2 | 2.1e-07 | 0.05 | 0.64 | 0.02 | FALSE |
| 7 | GTEx | Colon Transverse | MYO9A | 0.13 | 0.06 | lasso | 4 | 0.09 | 7.0e-05 | -1.8 | -5.2 | 2.3e-07 | -0.11 | 0.24 | 0.04 | TRUE |
| 8 | GTEx | Lung | PARP6 | 0.09 | 0.03 | lasso | 5 | 0.01 | 8.1e-02 | 7.5 | 5.2 | 1.6e-07 | 0.04 | 0.43 | 0.02 | TRUE |
| 9 | GTEx | Nerve Tibial | MYO9A | 0.13 | 0.13 | lasso | 3 | 0.11 | 2.1e-08 | 7.5 | -9.1 | 1.1e-19 | -0.44 | 0.92 | 0.08 | FALSE |
| 10 | GTEx | Nerve Tibial | PARP6 | 0.09 | 0.07 | lasso | 11 | 0.06 | 7.2e-05 | 8.9 | 8.9 | 4.0e-19 | 0.90 | 0.06 | 0.90 | TRUE |
| 11 | GTEx | Stomach | MYO9A | 0.17 | 0.06 | lasso | 5 | 0.01 | 1.1e-01 | 7.9 | -7.9 | 2.7e-15 | -0.18 | 0.60 | 0.02 | TRUE |
| 12 | GTEx | Thyroid | PARP6 | 0.23 | 0.02 | enet | 21 | 0.07 | 9.0e-06 | 9.0 | 8.0 | 1.4e-15 | 0.73 | 0.23 | 0.75 | TRUE |
| 13 | The Cancer Genome Atlas | Esophageal Carcinoma | SENP8 | 0.30 | 0.04 | enet | 22 | 0.12 | 1.2e-04 | 7.8 | -8.2 | 3.4e-16 | -0.58 | 0.01 | 0.39 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NR2E3 | 0.03 | 0.06 | lasso | 1 | 0.05 | 3.8e-06 | 7.3 | -7.3 | 2.5e-13 | -0.14 | 0.00 | 0.99 | TRUE |
| 15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NR2E3 | 0.05 | 0.04 | lasso | 2 | 0.03 | 2.7e-04 | 5.9 | -6.0 | 1.9e-09 | -0.07 | 0.22 | 0.02 | FALSE |
| 16 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | NR2E3 | 0.07 | 0.02 | blup | 38 | 0.05 | 4.4e-03 | 7.2 | -7.9 | 3.7e-15 | -0.22 | 0.03 | 0.10 | FALSE |