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chr17:36,211,659-38,991,052

Best TWAS P=1.68e-24 · Best GWAS P=1.36e-23 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	GTEx	Testis	PSMB3	0.30	0.24	lasso	4	0.21	8.9e-10	-10.0	-10.2	1.7e-24	1.00	0.00	1.00	TRUE
7	GTEx	Artery Tibial	MSL1	0.19	0.14	lasso	2	0.15	4.9e-12	6.7	-7.3	2.8e-13	-0.04	1.00	0.00	TRUE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	IGFBP4	0.04	0.02	blup	38	0.03	5.9e-04	-9.5	-6.0	2.1e-09	0.12	0.00	0.97	TRUE
3	GTEx	Adrenal Gland	SNORD124	0.22	0.01	lasso	6	0.02	4.8e-02	-5.4	5.8	8.2e-09	0.01	0.04	0.17	TRUE
36	The Cancer Genome Atlas	Thyroid Carcinoma	PSMB3	0.05	0.06	lasso	1	0.05	2.4e-05	-10.0	-10.0	1.4e-23	1.00	0.00	1.00	FALSE
35	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PSMB3	0.12	0.09	lasso	3	0.06	3.0e-03	-9.7	-9.8	7.1e-23	0.97	0.00	0.93	FALSE
24	NTR	Blood	PIP4K2B	0.02	0.01	lasso	3	0.01	6.4e-04	-10.0	9.6	7.8e-22	-0.97	0.00	1.00	FALSE
1	GTEx	Adipose Subcutaneous	PIP4K2B	0.15	0.07	lasso	5	0.07	2.2e-06	-10.0	-9.2	2.9e-20	0.95	0.00	1.00	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	PIP4K2B	0.05	0.04	blup	56	0.05	5.3e-06	-7.6	-8.9	5.6e-19	0.86	0.00	0.99	FALSE
6	GTEx	Artery Tibial	PIP4K2B	0.37	0.16	enet	49	0.22	2.1e-17	-10.0	-8.9	7.6e-19	0.76	0.00	1.00	FALSE
4	GTEx	Artery Aorta	PSMB3	0.23	0.17	enet	26	0.22	2.1e-12	-10.0	-8.3	1.1e-16	0.84	0.00	1.00	FALSE
5	GTEx	Artery Tibial	PSMB3	0.10	0.02	enet	12	0.03	1.2e-03	-10.0	-8.0	9.0e-16	0.73	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSMB3	0.14	0.05	blup	42	0.05	8.9e-07	-9.7	-7.5	4.5e-14	0.70	0.00	1.00	FALSE
23	METSIM	Adipose	PSMB3	0.04	0.02	lasso	5	0.01	2.3e-03	-7.2	-7.5	7.8e-14	0.51	0.14	0.31	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PIP4K2B	0.04	0.01	blup	56	0.03	6.3e-04	-9.7	-7.2	4.8e-13	0.83	0.00	0.92	FALSE
13	GTEx	Nerve Tibial	MSL1	0.33	0.25	lasso	4	0.24	6.3e-17	6.7	-7.1	1.0e-12	-0.03	1.00	0.00	FALSE
10	GTEx	Colon Transverse	MSL1	0.18	0.11	lasso	3	0.05	2.1e-03	6.7	-7.1	1.6e-12	-0.03	0.23	0.04	FALSE
21	METSIM	Adipose	MSL1	0.12	0.06	lasso	10	0.06	1.8e-09	6.7	-7.0	3.2e-12	-0.04	0.99	0.00	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMB3	0.12	0.02	enet	14	0.05	1.3e-03	-7.6	-7.0	3.3e-12	0.63	0.01	0.74	FALSE
17	GTEx	Skin Sun Exposed Lower leg	MSL1	0.08	0.04	lasso	2	0.05	8.1e-05	6.0	-7.0	3.5e-12	-0.05	0.52	0.03	FALSE
2	GTEx	Adipose Subcutaneous	MSL1	0.15	0.12	lasso	2	0.12	3.9e-10	6.7	-6.7	2.2e-11	-0.03	1.00	0.00	FALSE
14	GTEx	Pituitary	CWC25	0.30	0.00	enet	18	0.07	7.4e-03	-6.1	-6.6	3.4e-11	0.46	0.08	0.25	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMB3	0.11	0.07	blup	42	0.07	9.4e-08	-10.0	-6.6	3.7e-11	0.77	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RAPGEFL1	0.13	0.02	enet	9	0.06	4.3e-04	5.9	-6.6	3.8e-11	-0.01	0.00	0.89	FALSE
19	GTEx	Testis	PIP4K2B	0.22	0.00	enet	19	0.03	1.9e-02	-6.1	6.6	4.7e-11	-0.40	0.04	0.39	FALSE
12	GTEx	Esophagus Muscularis	MSL1	0.25	0.18	lasso	8	0.22	1.7e-13	6.1	-6.5	6.1e-11	-0.02	1.00	0.00	FALSE
9	GTEx	Breast Mammary Tissue (Female)	MSL1	0.09	0.00	enet	9	0.03	5.8e-02	6.7	-6.5	1.0e-10	-0.07	0.03	0.08	FALSE
25	YFS	Blood	PSMB3	0.14	0.11	enet	31	0.16	7.2e-49	-9.7	-6.5	1.0e-10	0.81	0.00	1.00	FALSE
15	GTEx	Pituitary	MSL1	0.40	0.27	lasso	7	0.24	1.3e-06	6.1	-6.4	1.6e-10	-0.01	0.20	0.22	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	MSL1	0.18	0.15	lasso	4	0.15	2.1e-08	6.7	-6.4	1.7e-10	-0.01	0.90	0.02	FALSE
8	GTEx	Breast Mammary Tissue	MSL1	0.20	0.06	lasso	6	0.07	2.2e-04	6.7	-6.4	1.9e-10	-0.03	0.40	0.14	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PIP4K2B	0.07	0.01	enet	12	0.02	4.3e-03	-6.1	-6.3	2.1e-10	0.52	0.03	0.29	FALSE
11	GTEx	Esophagus Mucosa	CWC25	0.11	0.07	enet	7	0.05	1.5e-04	-5.7	-6.1	1.2e-09	0.47	0.32	0.55	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PSMB3	0.04	0.00	blup	37	0.02	6.7e-03	-2.5	-5.8	5.9e-09	0.72	0.01	0.63	FALSE
22	METSIM	Adipose	PIP4K2B	0.06	0.01	blup	360	0.02	7.0e-04	-2.5	-5.5	4.5e-08	0.50	0.01	0.98	FALSE
20	METSIM	Adipose	LINC00672	0.07	0.01	bslmm	351	0.01	9.1e-03	1.8	5.3	1.3e-07	-0.42	0.04	0.55	FALSE