Best TWAS P=7.69e-09 · Best GWAS P=6.89e-12 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | MLX | 0.03 | 0.03 | enet | 12 | 0.02 | 6.5e-04 | -4.5 | -5.8 | 7.7e-09 | 0.87 | 0.04 | 0.94 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | RAB5C | 0.21 | 0.18 | bslmm | 326 | 0.18 | 8.1e-21 | 4.2 | 5.2 | 1.7e-07 | -0.25 | 0.25 | 0.68 | FALSE |
3 | GTEx | Adipose Subcutaneous | HSD17B1P1 | 0.06 | 0.09 | enet | 6 | 0.09 | 4.0e-08 | -4.4 | -5.5 | 4.0e-08 | 0.72 | 0.92 | 0.07 | TRUE |
4 | GTEx | Adipose Visceral Omentum | HSD17B1P1 | 0.09 | 0.06 | lasso | 3 | 0.05 | 1.7e-03 | 5.2 | -5.5 | 4.8e-08 | 0.56 | 0.14 | 0.42 | FALSE |
5 | GTEx | Artery Coronary | RP11-400F19.6 | 0.15 | 0.02 | lasso | 3 | 0.03 | 4.1e-02 | -5.9 | 5.6 | 1.7e-08 | -0.87 | 0.06 | 0.38 | TRUE |
6 | GTEx | Brain Cerebellum | HSD17B1P1 | 0.17 | 0.16 | lasso | 4 | 0.20 | 1.7e-06 | -4.6 | -5.7 | 1.5e-08 | 0.86 | 0.13 | 0.81 | FALSE |
7 | GTEx | Cells EBV-transformed lymphocytes | HSD17B1 | 0.14 | 0.13 | enet | 8 | 0.12 | 8.9e-05 | 4.9 | -5.6 | 2.4e-08 | 0.70 | 0.11 | 0.67 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | HSD17B1P1 | 0.07 | 0.03 | lasso | 3 | 0.02 | 5.2e-03 | 5.2 | -5.3 | 1.1e-07 | 0.68 | 0.23 | 0.61 | TRUE |
9 | YFS | Blood | STAT5B | 0.04 | 0.02 | lasso | 3 | 0.02 | 4.2e-06 | 5.2 | 5.2 | 2.1e-07 | -0.19 | 0.94 | 0.01 | TRUE |
10 | The Cancer Genome Atlas | Colon Adenocarcinoma | CNTNAP1 | 0.06 | 0.05 | blup | 27 | 0.03 | 7.3e-03 | -5.0 | 5.6 | 2.1e-08 | -0.86 | 0.01 | 0.92 | FALSE |
11 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TUBG2 | 0.09 | 0.01 | blup | 29 | 0.03 | 1.9e-02 | 4.9 | -5.4 | 6.5e-08 | 0.75 | 0.02 | 0.41 | TRUE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | CNTNAP1 | 0.04 | 0.03 | blup | 27 | 0.05 | 2.7e-05 | -6.9 | 5.8 | 7.9e-09 | -0.93 | 0.01 | 0.99 | FALSE |