Best TWAS P=2.04e-102 · Best GWAS P=1.03e-137 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C2orf73 | 0.06 | 0.01 | lasso | 5 | 0.03 | 2.0e-04 | -4.603 | 6.4 | 1.6e-10 | -0.09 | 0.43 | 0.12 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | EFEMP1 | 0.31 | 0.08 | bslmm | 493 | 0.24 | 1.4e-28 | 3.581 | -5.6 | 2.5e-08 | 0.43 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Brain Caudate basal ganglia | HMGB1P31 | 0.31 | 0.23 | lasso | 5 | 0.19 | 3.8e-06 | -5.802 | -6.1 | 1.3e-09 | 0.05 | 0.05 | 0.86 | TRUE |
| 4 | GTEx | Brain Frontal Cortex BA9 | EFEMP1 | 0.19 | 0.10 | lasso | 8 | 0.08 | 3.7e-03 | -21.004 | -21.5 | 2.0e-102 | 0.78 | 0.04 | 0.70 | TRUE |
| 5 | GTEx | Brain Frontal Cortex BA9 | HMGB1P31 | 0.17 | 0.03 | enet | 9 | 0.07 | 7.3e-03 | -5.802 | -5.9 | 4.4e-09 | 0.06 | 0.06 | 0.74 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | EFEMP1 | 0.11 | 0.00 | enet | 22 | 0.05 | 1.1e-04 | -0.442 | -12.0 | 2.8e-33 | 0.39 | 0.16 | 0.57 | TRUE |
| 7 | GTEx | Colon Transverse | RP11-477N3.1 | 0.20 | 0.03 | lasso | 7 | 0.08 | 1.8e-04 | -4.129 | 5.5 | 2.9e-08 | -0.12 | 0.12 | 0.62 | FALSE |
| 8 | GTEx | Esophagus Muscularis | RP11-477N3.1 | 0.21 | 0.10 | lasso | 5 | 0.15 | 1.5e-09 | -5.802 | 5.8 | 8.4e-09 | -0.07 | 0.05 | 0.95 | FALSE |
| 9 | GTEx | Stomach | SMEK2 | 0.14 | 0.02 | enet | 19 | 0.04 | 3.9e-03 | -1.056 | -7.1 | 1.6e-12 | 0.08 | 0.10 | 0.04 | TRUE |
| 10 | GTEx | Stomach | HMGB1P31 | 0.11 | 0.07 | lasso | 4 | 0.07 | 3.1e-04 | -3.348 | -5.7 | 9.8e-09 | 0.09 | 0.06 | 0.87 | FALSE |
| 11 | GTEx | Testis | MTIF2 | 0.13 | 0.01 | enet | 23 | 0.01 | 8.5e-02 | -5.172 | 5.6 | 2.1e-08 | 0.05 | 0.14 | 0.04 | TRUE |
| 12 | GTEx | Whole Blood | RP11-554J4.1 | 0.13 | 0.03 | lasso | 5 | 0.03 | 6.4e-04 | -5.688 | -8.0 | 1.8e-15 | 0.08 | 0.16 | 0.13 | FALSE |
| 13 | METSIM | Adipose | EFEMP1 | 0.03 | 0.01 | lasso | 2 | 0.01 | 2.8e-03 | 7.243 | -5.6 | 1.7e-08 | -0.15 | 0.09 | 0.03 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | EFEMP1 | 0.29 | 0.14 | enet | 37 | 0.19 | 2.2e-24 | -11.899 | -12.1 | 1.5e-33 | 0.64 | 1.00 | 0.00 | TRUE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | PNPT1 | 0.06 | 0.01 | blup | 464 | 0.01 | 1.1e-02 | 2.916 | 8.6 | 8.1e-18 | -0.12 | 0.76 | 0.01 | TRUE |
| 16 | YFS | Blood | SMEK2 | 0.07 | 0.04 | enet | 34 | 0.05 | 7.1e-17 | 0.087 | 6.8 | 9.4e-12 | -0.24 | 1.00 | 0.00 | TRUE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ACYP2 | 0.02 | 0.00 | blup | 122 | 0.01 | 2.0e-02 | -3.954 | 5.3 | 1.4e-07 | -0.12 | 0.01 | 0.95 | FALSE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EFEMP1 | 0.02 | 0.01 | blup | 79 | 0.02 | 3.9e-05 | -24.979 | 11.2 | 2.9e-29 | -0.73 | 0.00 | 1.00 | FALSE |