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chr2:53,583,159-56,843,605

Best TWAS P=2.04e-102 · Best GWAS P=1.03e-137 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Brain Frontal Cortex BA9	EFEMP1	0.19	0.10	lasso	8	0.08	3.7e-03	-21.004	-21.5	2.0e-102	0.78	0.04	0.70	TRUE
14	ROSMAP	Brain Pre-frontal Cortex	EFEMP1	0.29	0.14	enet	37	0.19	2.2e-24	-11.899	-12.1	1.5e-33	0.64	1.00	0.00	TRUE
6	GTEx	Cells Transformed fibroblasts	EFEMP1	0.11	0.00	enet	22	0.05	1.1e-04	-0.442	-12.0	2.8e-33	0.39	0.16	0.57	TRUE
15	ROSMAP	Brain Pre-frontal Cortex	PNPT1	0.06	0.01	blup	464	0.01	1.1e-02	2.916	8.6	8.1e-18	-0.12	0.76	0.01	TRUE
9	GTEx	Stomach	SMEK2	0.14	0.02	enet	19	0.04	3.9e-03	-1.056	-7.1	1.6e-12	0.08	0.10	0.04	TRUE
16	YFS	Blood	SMEK2	0.07	0.04	enet	34	0.05	7.1e-17	0.087	6.8	9.4e-12	-0.24	1.00	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	C2orf73	0.06	0.01	lasso	5	0.03	2.0e-04	-4.603	6.4	1.6e-10	-0.09	0.43	0.12	TRUE
3	GTEx	Brain Caudate basal ganglia	HMGB1P31	0.31	0.23	lasso	5	0.19	3.8e-06	-5.802	-6.1	1.3e-09	0.05	0.05	0.86	TRUE
11	GTEx	Testis	MTIF2	0.13	0.01	enet	23	0.01	8.5e-02	-5.172	5.6	2.1e-08	0.05	0.14	0.04	TRUE
2	CommonMind	Brain Pre-frontal Cortex	EFEMP1	0.31	0.08	bslmm	493	0.24	1.4e-28	3.581	-5.6	2.5e-08	0.43	1.00	0.00	TRUE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFEMP1	0.02	0.01	blup	79	0.02	3.9e-05	-24.979	11.2	2.9e-29	-0.73	0.00	1.00	FALSE
12	GTEx	Whole Blood	RP11-554J4.1	0.13	0.03	lasso	5	0.03	6.4e-04	-5.688	-8.0	1.8e-15	0.08	0.16	0.13	FALSE
5	GTEx	Brain Frontal Cortex BA9	HMGB1P31	0.17	0.03	enet	9	0.07	7.3e-03	-5.802	-5.9	4.4e-09	0.06	0.06	0.74	FALSE
8	GTEx	Esophagus Muscularis	RP11-477N3.1	0.21	0.10	lasso	5	0.15	1.5e-09	-5.802	5.8	8.4e-09	-0.07	0.05	0.95	FALSE
10	GTEx	Stomach	HMGB1P31	0.11	0.07	lasso	4	0.07	3.1e-04	-3.348	-5.7	9.8e-09	0.09	0.06	0.87	FALSE
13	METSIM	Adipose	EFEMP1	0.03	0.01	lasso	2	0.01	2.8e-03	7.243	-5.6	1.7e-08	-0.15	0.09	0.03	FALSE
7	GTEx	Colon Transverse	RP11-477N3.1	0.20	0.03	lasso	7	0.08	1.8e-04	-4.129	5.5	2.9e-08	-0.12	0.12	0.62	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	ACYP2	0.02	0.00	blup	122	0.01	2.0e-02	-3.954	5.3	1.4e-07	-0.12	0.01	0.95	FALSE