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chr19:36,282,543-38,725,416

Best TWAS P=6.85e-14 · Best GWAS P=9.94e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	GTEx	Stomach	ZNF585B	0.07	0.07	lasso	5	0.05	1.4e-03	-7.5	-7.5	6.8e-14	0.99	0.02	0.96	TRUE
14	GTEx	Nerve Tibial	ZNF585A	0.06	0.07	lasso	9	0.06	6.9e-05	-7.6	-7.5	9.6e-14	0.99	0.04	0.96	FALSE
6	GTEx	Artery Aorta	ZNF829	0.11	0.04	lasso	2	0.00	2.5e-01	-7.6	7.3	2.2e-13	-0.99	0.02	0.87	FALSE
5	GTEx	Adipose Visceral Omentum	ZNF585B	0.06	0.02	enet	8	0.00	2.5e-01	-7.6	-7.0	2.1e-12	0.96	0.02	0.81	FALSE
16	GTEx	Spleen	ZNF585A	0.23	0.10	lasso	8	0.07	5.9e-03	-7.7	-7.0	2.5e-12	0.95	0.02	0.86	FALSE
10	GTEx	Cells Transformed fibroblasts	ZNF585B	0.17	0.20	enet	19	0.22	1.2e-16	-7.6	-6.8	1.0e-11	0.93	0.02	0.98	FALSE
4	GTEx	Adipose Subcutaneous	ZNF585B	0.10	0.10	lasso	8	0.12	1.2e-09	6.4	-6.7	2.3e-11	0.90	0.02	0.98	FALSE
13	GTEx	Lung	ZNF585B	0.06	0.08	lasso	5	0.07	7.0e-06	6.4	-6.6	3.1e-11	0.91	0.03	0.97	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	ZNF585B	0.13	0.10	enet	20	0.13	4.3e-05	-7.6	-6.6	4.3e-11	0.76	0.03	0.94	FALSE
18	GTEx	Thyroid	ZNF585B	0.04	0.03	lasso	6	0.01	4.0e-02	6.6	-6.5	5.9e-11	0.93	0.05	0.80	FALSE
11	GTEx	Esophagus Mucosa	ZNF585B	0.10	0.04	lasso	4	0.05	2.2e-04	-7.6	-6.4	1.3e-10	0.85	0.02	0.97	FALSE
15	GTEx	Pituitary	CTD-2630F21.1	0.14	0.02	lasso	7	-0.01	4.6e-01	6.3	-6.3	2.5e-10	0.90	0.02	0.69	FALSE
7	GTEx	Artery Tibial	ZNF585B	0.17	0.14	lasso	15	0.22	5.6e-17	-5.7	-6.3	3.9e-10	0.88	0.03	0.97	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF568	0.01	0.01	blup	64	0.01	1.3e-03	-5.0	6.2	5.4e-10	-0.87	0.09	0.68	FALSE
27	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ZNF568	0.11	0.09	blup	63	0.09	4.1e-04	6.3	6.2	5.9e-10	-0.91	0.04	0.87	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF585B	0.07	0.06	enet	11	0.07	3.4e-07	-5.7	-6.1	9.9e-10	0.84	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF585B	0.03	0.02	enet	4	0.02	5.4e-06	-7.7	-6.1	1.1e-09	0.85	0.00	0.99	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF585B	0.12	0.04	enet	9	0.07	5.6e-08	-7.7	-6.0	2.2e-09	0.84	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	ZNF585A	0.09	0.02	lasso	3	0.02	3.8e-03	-5.1	-5.9	3.5e-09	0.82	0.06	0.86	FALSE
8	GTEx	Brain Cerebellum	ZNF793	0.23	0.02	enet	40	0.07	4.8e-03	-7.6	5.8	5.2e-09	-0.77	0.03	0.72	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF585B	0.11	0.04	blup	33	0.06	1.3e-07	-5.7	-5.8	5.2e-09	0.72	0.01	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ZNF585B	0.09	0.06	enet	20	0.09	2.6e-11	-7.6	-5.8	8.0e-09	0.83	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ZNF585A	0.08	0.10	lasso	3	0.11	2.6e-13	-5.7	5.7	1.2e-08	-0.80	0.96	0.04	FALSE
12	GTEx	Esophagus Muscularis	ZNF585B	0.14	0.06	enet	23	0.12	1.4e-07	-2.7	-5.5	5.1e-08	0.82	0.06	0.94	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF585B	0.13	0.03	enet	9	0.08	1.5e-09	-7.7	-5.4	6.4e-08	0.80	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF568	0.20	0.14	lasso	2	0.14	9.3e-14	-5.4	5.4	7.9e-08	-0.72	1.00	0.00	FALSE
20	YFS	Blood	HKR1	0.04	0.05	blup	305	0.05	6.4e-16	-3.1	5.3	1.2e-07	-0.70	1.00	0.00	FALSE
19	GTEx	Whole Blood	HKR1	0.07	0.01	lasso	8	0.02	5.1e-03	-3.4	5.3	1.5e-07	-0.79	0.04	0.94	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF585B	0.05	0.00	blup	32	0.03	1.1e-04	-7.7	-5.2	2.1e-07	0.77	0.00	0.95	FALSE