Hub : Genes

ZNF585A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0850 0.0280 3.6e-10 0.095 0.093 0.110 0.098 0.110 1.2e-11 1.9e-11 2.8e-13 5.7e-12 2.6e-13
2 GTEx Adipose Subcutaneous 0.0920 0.0450 8.9e-04 0.022 NA 0.020 NA 0.025 5.8e-03 NA 8.4e-03 NA 3.8e-03
3 GTEx Cells Transformed fibroblasts 0.0640 0.0350 2.8e-03 0.035 NA 0.014 NA 0.031 1.1e-03 NA 3.1e-02 NA 2.0e-03
4 GTEx Nerve Tibial 0.0633 0.0281 2.1e-04 0.074 NA 0.044 NA 0.057 6.0e-06 NA 4.4e-04 NA 6.9e-05
5 GTEx Spleen 0.2310 0.1030 1.3e-03 0.095 NA 0.074 NA 0.074 2.0e-03 NA 6.0e-03 NA 5.9e-03
6 TCGA Bladder Urothelial Carcinoma 0.0370 0.0230 8.6e-03 0.013 0.015 0.013 NA 0.014 2.4e-02 1.8e-02 2.6e-02 NA 2.3e-02
7 TCGA Colon Adenocarcinoma 0.0830 0.0500 5.3e-04 0.060 0.053 0.046 NA 0.048 2.4e-04 5.0e-04 1.2e-03 NA 9.0e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.2 0.4 0.9 0.6 0.0 -0.9 0.8 0.1 0.9 0.2
Bipolar Disorder or Schizophrenia 0.2 0.6 1.4 0.2 0.6 -1.0 1.2 0.3 1.1 0.1
Depressed Affect (Nagel 2018) 1.0 2.0 4.5 1.5 -1.8 -0.7 -2.1 -1.6 -1.1 0.5
Depression (Nagel 2018) 0.7 1.0 4.5 -0.0 -1.2 -2.1 0.1 0.1 0.7 0.6
Intelligence (Savage-Jansen 2018) 1.0 3.0 5.8 -1.1 2.4 1.7 0.7 0.8 -2.4 -2.1
Neuroticism (Nagel 2018) 1.3 3.0 7.3 1.5 -2.0 0.2 -2.7 -2.1 -1.6 0.7
Schizophrenia (2018) 0.2 0.3 0.8 -0.3 0.7 -0.6 0.9 0.2 0.7 -0.0
Schizophrenia vs Biploar Disorder 0.2 0.2 0.4 0.3 -0.3 0.6 -0.7 -0.4 -0.6 0.2
Worry (Nagel 2018) 1.1 2.2 6.1 0.9 -1.5 0.5 -2.5 -1.9 -1.3 1.0
Alzheimer’s Disease (in mother) 1.3 1.5 2.9 1.7 -1.3 -0.2 -1.3 -1.3 0.6 1.4
Alzheimer’s Disease (in father) 1.3 1.4 3.0 -1.0 1.7 0.0 1.1 1.4 -1.1 -1.4
Alzheimer’s Disease (including proxy) 0.0 0.1 0.2 0.4 0.2 0.2 0.0 0.3 -0.1 0.1
Crohns Disease (2017) 4.8 10.6 19.8 3.7 -3.9 1.2 -4.4 -4.2 -0.2 2.4
Irritable Bowel Disease (IBD) 2.6 6.1 14.0 2.3 -2.8 0.6 -3.7 -3.4 -0.9 1.6
Ulcerative Colitis (UC) 0.3 0.6 1.6 0.3 -0.7 -0.3 -1.3 -1.1 -0.7 0.3
Major Depression (MDD) 0.6 0.8 4.0 -0.4 -0.6 -2.0 -0.1 -0.1 0.7 0.6
Reaction Time 3.4 6.5 14.4 -2.6 3.1 0.9 2.0 1.7 -2.6 -3.8
Verbal and Numeric Reasoning (VNR) 1.3 3.2 5.7 -1.7 2.4 1.6 0.9 1.1 -2.1 -2.2
Breast Cancer 1.8 4.3 9.4 -3.1 2.8 -0.4 2.4 2.1 -0.1 -1.6
Ovarian Cancer 1.9 2.6 3.9 1.5 -1.9 -2.0 -0.8 -1.6 1.7 1.4
Prostate Cancer 1.3 1.9 6.1 0.5 -0.5 -2.5 1.0 0.3 2.0 1.2
Age at First Birth 1.2 1.7 3.3 1.0 -1.8 1.4 -1.5 -1.5 -1.0 -0.0
Bipolar Disorder (2011) 1.7 1.6 4.1 -0.7 1.3 -1.2 2.0 1.3 1.4 -0.5
Body Mass Index (BMI) (2010) 0.3 0.5 1.3 -0.5 0.5 -1.1 0.7 0.5 0.7 0.3
Coronary Artery Disease (CAD) 1.0 1.2 3.9 -0.3 0.5 -0.5 0.3 0.3 -2.0 -1.9
Crohns Disease (2012) 4.7 7.6 14.4 3.5 -3.5 0.8 -3.4 -3.8 -0.8 1.1
Mean Putamen Volume 0.5 0.6 2.5 0.2 0.6 0.6 0.5 0.1 -0.8 -1.6
Fasting Glucose 0.1 0.1 0.3 0.6 -0.0 -0.6 -0.1 -0.5 -0.1 -0.1
HbA1C 2.3 2.6 5.1 2.3 -1.8 -0.8 -0.8 -1.4 1.8 1.8
HDL Cholesterol 1.0 1.7 3.1 1.1 -1.4 0.5 -1.4 -1.4 1.1 1.8
LDL Cholesterol 0.1 0.1 0.4 -0.3 0.0 0.6 0.3 0.1 -0.3 -0.1
Lupus 2.2 3.3 10.0 0.0 0.5 2.7 -1.7 -1.1 -3.2 -1.3
Neuroticism (2016) 0.6 0.9 2.1 0.4 -1.4 -0.9 -1.2 -0.4 0.4 1.3
Primary Biliary Cirrhosis 5.1 7.3 13.5 3.4 -3.7 -1.2 -2.5 -3.3 1.3 2.4
Rheumatoid Arthritis 1.0 1.4 3.1 -1.8 1.3 0.1 1.0 1.4 -0.8 -1.0
Schizophrenia (2014) 0.0 0.1 0.3 0.3 0.2 -0.5 0.0 -0.5 0.1 0.3
Triglycerides 0.9 1.4 9.1 -0.2 -0.5 -3.0 0.6 0.0 0.5 -0.1
Type 2 Diabetes (T2D) (2012) 1.8 2.1 4.0 1.7 -2.0 -0.1 -1.7 -1.5 0.3 1.6
Ulcerative Colitis 0.2 0.3 0.8 0.1 -0.5 -0.5 -0.9 -0.4 -0.6 0.1
Blood Eosinophil Count 3.3 25.4 41.3 6.4 -6.3 -0.3 -5.8 -5.6 1.7 5.3
Blood Platelet Count 1.2 13.7 24.1 -3.1 4.4 1.6 4.5 4.9 -1.7 -4.1
Blood Red Count 0.3 3.2 9.6 -2.0 1.7 0.7 1.8 0.9 -1.1 -3.1
Blood White Count 0.7 5.5 9.9 -2.1 2.4 -0.3 3.1 3.1 -0.7 -2.8
Heel T-Score 0.0 0.4 0.9 -0.4 -0.3 0.8 -0.1 -0.2 -0.8 -1.0
BMI 0.8 4.8 8.8 -2.5 2.5 -0.1 3.0 2.8 -0.2 -2.2
Height 4.5 86.4 148.8 11.0 -11.1 1.5 -12.2 -11.8 -0.3 8.4
Waist Hip Ratio (WHR) 1.2 5.5 9.0 -2.7 2.1 -3.0 2.9 2.8 1.2 -0.7
Systolic Blood Pressure 2.7 13.8 24.2 3.5 -3.1 4.0 -4.6 -4.9 -3.6 -0.1
Smoking Status 0.1 0.3 0.5 0.7 0.3 0.7 -0.5 -0.4 0.2 0.7
Allergy or Eczema 1.5 3.9 7.3 1.6 -2.7 -1.7 -1.7 -1.4 1.9 2.5
Cardiovascular Disease 1.2 4.1 13.5 0.2 -0.7 3.7 -1.8 -1.4 -2.7 -1.3
Hypothyroidism (self reported) 0.4 0.9 1.6 -1.1 0.8 1.3 -1.1 -0.2 -1.3 0.1
Respiratory disease 1.3 2.8 6.0 1.8 -1.7 0.0 -2.4 -2.1 -0.2 1.7
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.6 -0.7 -0.1 0.8 -0.2 0.2 0.2 0.4
Lung FEV1/FVC ratio 2.5 12.7 20.5 -3.6 3.6 3.5 2.9 3.3 -3.2 -4.5
Lung FVC 0.2 0.9 2.5 -1.0 0.7 -0.8 1.6 0.9 0.8 -0.8
Neuroticism 1.3 3.0 8.0 1.0 -1.8 0.4 -2.8 -1.9 -2.2 0.5
Chronotype (morning person) 0.6 1.3 2.8 1.1 -0.9 1.7 -1.2 -0.8 0.6 1.5
Hair Pigment 0.3 7.5 11.6 2.9 -3.4 -2.1 -2.1 -2.3 2.7 3.4
Tanning 0.4 5.0 11.3 -1.3 2.2 -2.3 3.4 2.6 2.3 0.2
Hand grip strength (left) 5.2 13.6 23.0 4.8 -4.7 1.0 -4.1 -4.5 1.2 3.2
Number of treatments/medications taken 0.1 0.2 0.5 -0.7 0.1 0.5 -0.4 0.0 -0.4 0.2
Average weekly spirits intake 0.8 1.0 1.8 1.3 -1.1 0.3 -1.3 -1.2 0.2 1.0
Sensitivity / hurt feelings 1.2 2.0 5.2 -2.3 1.5 0.3 1.0 1.3 -1.5 -1.3
Frequency of depressed mood in last 2 weeks 0.5 0.7 3.5 -0.1 -0.8 -1.9 -0.4 -0.1 0.1 0.5
Hearing difficulty/problems: Yes 2.2 3.4 6.1 -2.5 2.3 -0.0 2.0 1.8 -0.9 -1.9
Relative age of first facial hair 0.5 1.1 2.3 0.4 -1.0 -1.3 -0.5 -0.4 1.4 1.5
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.2 -0.9 0.4 0.1 0.5 1.1 -0.2 -0.5
Ever used hormone-replacement therapy (HRT) 0.6 0.7 2.1 0.8 -0.8 0.1 -1.5 -0.8 -0.4 0.8
Ever had hysterectomy (womb removed) 0.5 0.6 1.7 0.7 -0.6 -0.2 0.4 0.7 1.3 0.9
Systolic blood pressure, automated reading 1.3 3.8 5.3 1.9 -1.7 2.3 -2.2 -2.3 -2.2 -0.4
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 0.1 0.1 0.2 0.4 -0.0 0.5 -0.2
Angina 2.2 2.9 5.0 -1.8 2.2 1.2 1.7 2.0 -1.0 -1.7
Medication for hormone replacement therapy 1.2 1.4 5.8 -0.1 0.1 -2.4 0.5 0.8 1.3 1.2
Vitamin and mineral supplements 4.6 6.3 13.1 3.4 -3.6 -0.2 -2.5 -2.9 0.9 1.9
Supplements: Zinc 0.2 0.2 0.5 0.6 0.2 -0.7 -0.3 -0.5 -0.5 0.0
Medication: Co-codamol 2.0 2.3 6.7 0.2 -0.6 -2.6 0.8 1.1 2.3 1.4
Medication: Metformin 0.4 0.5 1.6 -1.3 0.9 -0.1 0.5 0.7 0.6 0.5
Diabetes (father) 0.1 0.1 0.2 -0.3 -0.2 0.2 0.0 0.1 0.5 0.3
Diabetes (mother) 1.8 2.3 3.8 1.9 -1.8 0.3 -1.6 -1.5 0.6 1.9
Severe depression (siblings) 0.6 0.7 2.9 -0.3 0.6 0.6 -0.2 -0.4 -1.7 -1.0
Pack years adult smoking proportion 1.4 2.2 5.4 -1.9 2.3 1.0 1.5 1.6 -0.2 -0.4
Impedance of leg (right) 0.2 0.9 3.2 -0.2 -0.4 -1.8 -0.1 -0.4 1.2 1.1
Leg fat-free mass (left) 0.3 1.9 3.5 1.4 -1.1 1.5 -1.9 -1.5 -1.3 0.4
Trunk fat percentage 1.0 4.2 6.4 -2.4 2.2 -2.0 2.5 2.5 0.7 -1.1
Hand grip strength (right) 4.6 12.5 21.3 4.6 -4.6 1.2 -3.9 -4.2 1.1 3.0
Townsend deprivation index at recruitment 2.2 3.1 6.9 1.5 -1.2 -1.6 -0.7 -1.5 2.4 2.6
Current tobacco smoking 1.2 2.0 4.1 -1.3 1.4 -1.5 2.0 1.7 1.1 0.0
Average weekly fortified wine intake 0.8 0.9 3.3 -0.2 -0.1 -1.8 0.9 0.7 1.2 0.6
Maternal smoking around birth 1.4 2.1 4.4 -1.5 1.6 -2.1 1.6 1.5 0.9 0.1
Fed-up feelings 1.0 1.8 3.9 0.8 -0.9 -1.3 -2.0 -1.4 -1.9 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 3.2 -0.1 -0.9 -1.8 -0.0 -0.1 -0.1 -0.1
Relative age voice broke 1.8 2.8 5.0 -1.3 1.5 -2.2 2.2 1.9 1.6 -0.4
Taking other prescription medications 0.4 0.7 2.4 -0.5 -0.0 0.8 -1.0 -0.4 -1.6 -0.4
Age when periods started (menarche) 0.7 1.8 2.9 -1.2 0.7 -1.4 1.7 1.6 -0.2 -1.6
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.0 0.4 -0.1 -0.6 0.0 0.1 1.0 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 4.3 0.1 -0.1 -1.2 1.0 0.3 2.1 1.0
Tinnitus: Yes, but not now, but have in the past 2.1 2.3 4.8 -2.2 1.2 1.2 0.5 0.5 -1.9 -2.0
Qualifications: CSEs or equivalent 2.9 3.8 7.1 -2.1 2.2 -0.6 2.7 2.3 -0.3 -2.2
Serious illness, injury or assault to yourself 1.3 1.6 6.3 -0.2 0.4 -2.5 1.0 1.1 1.4 0.7
High blood pressure 1.8 5.0 12.1 0.0 -0.6 3.5 -2.4 -1.5 -3.5 -1.5
Hayfever, allergic rhinitis or eczema 1.5 3.2 6.4 1.8 -2.5 -1.0 -1.9 -1.7 1.2 2.1
Multivitamins +/- minerals 5.7 7.2 14.2 -3.2 3.8 -0.1 3.3 3.5 -0.1 -1.6
Stomach or abdominal pain in last month 0.5 0.6 1.3 0.6 -1.2 -0.5 -1.1 -0.7 -0.3 0.7
Supplements: Glucosamine 1.1 1.4 3.0 -1.6 1.7 -0.9 1.1 1.6 0.1 -0.3
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.2 0.2 -0.4 -0.0 -1.1 -1.0 -0.8 -0.1
Medication: Atenolol 0.1 0.1 0.3 -0.1 0.5 0.6 0.1 0.3 0.1 -0.0
Medication: Levothyroxine sodium 1.1 1.9 4.1 -1.5 1.6 1.5 -0.1 0.7 -2.0 -1.5
Sitting height 3.3 23.6 44.2 5.6 -5.6 1.2 -6.6 -5.9 -0.3 4.7
Chronic bronchitis/emphysema (father) 0.1 0.1 0.3 -0.5 -0.3 0.4 0.4 0.3 0.0 -0.3
High blood pressure (mother) 2.4 3.4 7.3 1.3 -1.1 2.1 -2.5 -1.7 -2.7 -0.3
Body mass index (BMI) 1.1 4.7 9.5 -2.2 2.3 -0.8 3.0 3.1 0.2 -1.8
Impedance of leg (left) 0.2 0.9 3.2 -0.3 -0.5 -1.8 -0.3 -0.6 1.1 1.0
Leg predicted mass (left) 0.4 1.9 3.6 1.4 -1.1 1.5 -1.9 -1.6 -1.4 0.3
Trunk fat mass 0.3 1.2 2.1 -1.4 1.3 -1.0 1.2 1.4 -0.0 -0.8
Waist circumference 1.4 5.2 8.2 -2.9 2.2 -2.2 2.8 2.9 0.4 -1.4
Number of incorrect matches in round 1.4 2.4 4.7 1.3 -2.0 -0.3 -2.2 -1.9 0.1 1.5
Past tobacco smoking 0.7 1.3 2.9 -1.1 0.8 -0.8 1.7 1.4 0.1 -1.3
Alcohol usually taken with meals 2.7 4.3 9.3 2.0 -2.6 0.7 -3.0 -2.8 -0.6 1.4
Nervous feelings 1.3 2.5 5.3 1.3 -1.5 0.0 -2.2 -2.3 0.1 1.7
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 2.0 -0.8 0.1 -0.6 -0.6 -0.3 -1.4 -0.7
Hearing difficulty/problems with background noise 0.2 0.3 0.7 -0.8 0.4 0.8 0.2 0.5 -0.2 -0.1
Hair/balding pattern: Pattern 2 1.4 1.7 4.6 -0.8 0.7 2.0 -0.8 -0.4 -2.1 -1.2
Had menopause 2.0 2.5 5.9 1.3 -1.2 1.4 -2.4 -1.6 -1.9 -0.1
Had other major operations 1.0 1.3 3.5 0.6 -0.9 -1.3 -0.9 -0.7 1.0 1.9
Forced vital capacity (FVC) 1.1 4.2 8.9 2.2 -2.3 1.7 -2.5 -3.0 -0.9 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.0 3.5 0.0 0.4 -1.4 1.0 0.4 1.9 0.8
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.0 -1.2 1.4 0.4 0.4 0.8 -1.4 -1.2
Qualifications: None of the above 0.3 0.7 1.7 -0.2 -0.6 -1.2 0.5 0.7 1.3 0.9
Financial difficulties in last 2 years 0.7 1.0 2.3 -0.6 0.6 -1.1 0.7 0.7 -1.4 -1.5
Mouth/teeth dental problems 0.2 0.3 0.5 0.7 -0.4 0.6 -0.3 -0.6 -0.6 -0.4
Heart attack 0.8 1.1 1.8 -1.3 1.3 0.8 0.6 0.5 -1.0 -1.3
Allergy 0.5 1.2 2.4 -0.8 1.4 1.1 0.8 0.8 -1.1 -1.5
Pain all over the body in last month 0.5 0.6 1.6 -0.5 0.5 0.5 0.6 0.4 -1.0 -1.3
Diabetes (self-reported) 0.1 0.1 0.4 -0.6 0.1 0.5 0.1 0.4 0.3 0.3
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 3.1 0.8 -1.4 -0.1 -1.8 -1.4 -1.1 0.3
Medication: Ramipril 2.1 2.7 4.0 -1.7 1.8 1.6 0.8 1.4 -1.7 -2.0
Medication: Simvastatin 0.4 0.7 1.2 -0.8 -0.1 1.1 0.9 1.1 0.8 -0.2
Fluid intelligence score 1.3 2.7 4.9 -1.4 1.9 2.0 0.3 0.9 -2.2 -1.9
Illnesses of siblings 0.2 0.2 0.9 -0.2 0.0 -0.3 0.5 0.3 0.9 0.5
Neuroticism score 1.7 3.6 9.2 1.4 -1.9 0.0 -3.0 -2.4 -2.0 0.8
Weight 0.0 0.1 0.2 0.3 -0.3 -0.2 -0.4 -0.1 -0.2 0.3
Impedance of arm (right) 0.2 1.1 3.3 0.4 -0.3 -1.8 -0.6 -0.9 1.1 1.4
Arm fat percentage (right) 1.7 6.9 12.0 -2.9 3.1 -1.6 3.5 3.4 0.4 -1.9
Trunk fat-free mass 1.2 6.6 13.1 3.0 -2.8 1.6 -3.6 -3.0 -1.4 1.5
Hip circumference 0.0 0.2 1.1 -0.1 -0.1 -1.0 -0.0 0.0 -0.3 -0.2
Time employed in main current job 0.1 0.1 0.2 -0.3 0.1 -0.5 0.4 0.0 -0.0 -0.4
Alcohol intake versus 10 years previously 0.6 1.0 3.5 -0.8 0.8 1.9 0.1 0.2 -0.9 -1.0
Father’s age at death 0.7 1.0 2.2 0.7 -0.4 0.9 -1.5 -1.5 -1.0 0.3
Worrier / anxious feelings 1.1 2.1 9.1 0.1 0.0 1.0 -1.4 -1.0 -3.0 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.6 -0.9 0.5 -1.3 0.7 1.1 -0.7 -0.7
Falls in the last year 3.8 5.1 9.2 -2.5 3.0 -0.6 3.0 3.0 0.4 -1.4
Hair/balding pattern: Pattern 3 1.1 1.7 4.2 -2.0 0.8 0.1 1.3 1.6 -0.6 -1.5
Number of live births 1.0 1.3 2.5 -1.3 1.1 -1.5 1.0 1.6 -0.2 -0.8
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 6.5 0.5 -0.5 2.5 -1.0 -1.4 -1.6 -0.8
Pulse rate 0.2 0.3 0.7 -0.5 0.2 0.0 -0.2 -0.1 -0.9 -0.8
Happiness 4.4 5.4 11.5 2.5 -2.8 0.6 -3.4 -2.9 -1.0 1.7
Noisy workplace 0.6 0.7 1.7 -1.3 0.9 0.2 0.9 0.8 -0.1 -0.9
Qualifications: A levels/AS levels or equivalent 0.3 0.8 1.6 1.0 -1.0 -1.3 -0.9 -0.2 0.5 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 3.1 0.3 -0.7 1.8 -0.9 -0.6 -1.1 -0.6
Mouth/teeth dental problems: Dentures 0.6 1.0 2.4 -0.5 0.5 -1.0 0.9 1.2 1.5 1.0
Asthma 0.8 1.6 3.2 1.1 -1.0 1.5 -1.8 -1.4 -0.7 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.3 -1.1 1.1 0.9 0.3 0.2 -1.0 -0.9
Medication: Cholesterol lowering 0.9 1.4 7.4 -0.4 0.3 2.7 -0.2 -0.0 -1.2 -0.9
Depression (self-reported) 0.8 0.9 2.0 -0.5 0.4 -1.4 0.6 0.5 1.4 1.3
Medication: Lansoprazole 1.1 1.3 4.1 -0.5 0.7 -2.0 1.1 1.0 1.4 0.5
Prospective memory result 0.3 0.3 0.9 -0.4 0.1 0.5 0.9 0.6 0.3 -0.8
Lung cancer (father) 0.7 0.8 1.1 -1.0 1.0 0.4 0.9 1.1 -0.9 -1.1
Illnesses of mother 1.7 2.1 3.9 -1.6 1.6 -1.3 2.0 1.6 0.6 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 4.6 1.0 -0.9 2.2 -1.3 -1.8 -1.3 -0.2
Pulse wave Arterial Stiffness index 1.5 1.8 4.2 -1.9 1.1 0.9 -0.4 -0.0 -2.0 -1.6
Impedance of arm (left) 0.3 1.4 4.3 0.2 -0.4 -2.1 -0.8 -1.0 1.1 1.5
Arm fat mass (right) 0.7 2.9 5.4 -1.8 2.0 -1.0 2.3 2.3 0.3 -1.2
Trunk predicted mass 1.2 6.7 13.3 3.0 -2.8 1.7 -3.6 -3.1 -1.4 1.5
Standing height 2.8 28.0 55.5 5.7 -5.9 1.4 -7.5 -7.0 -0.9 4.6
Length of working week for main job 0.5 0.6 1.8 -1.3 0.6 -0.7 0.6 0.6 -0.4 -0.7
Exposure to tobacco smoke at home 1.3 1.4 2.2 -1.4 0.8 1.2 0.8 1.1 -1.3 -1.5
Breastfed as a baby 0.3 0.4 0.7 0.6 0.2 -0.8 0.9 0.7 0.2 -0.6
Tense / ‘highly strung’ 2.9 4.7 10.1 1.8 -2.7 0.6 -3.2 -2.7 -0.4 2.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.8 -0.6 0.9 0.6 0.1 0.4 -0.9 -0.1
Hair/balding pattern: Pattern 4 0.1 0.3 1.1 0.2 0.9 1.1 0.3 0.1 -0.1 -0.3
Birth weight of first child 1.8 3.2 6.6 2.6 -1.8 -0.5 -1.2 -0.7 1.9 2.5
Peak expiratory flow (PEF) 1.2 2.8 6.7 0.8 -2.0 2.6 -1.9 -2.0 -0.5 0.5
Pulse wave reflection index 5.5 6.8 13.2 -3.6 3.3 0.0 2.6 2.4 -1.2 -2.9
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.7 0.6 -0.9 0.2 -0.5 -0.4 -0.5 0.1
Loud music exposure frequency 1.6 1.8 4.2 -0.8 1.0 1.6 0.3 0.6 -1.9 -2.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.7 0.1 0.4 0.3 -0.9 -0.8 -1.3 -0.5
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.7 0.2 -0.4 1.3 -1.1 -1.3 -0.7 0.1
Blood clot in the leg (DVT) 6.8 8.7 14.4 -3.7 3.8 -0.6 3.3 3.2 -1.1 -3.2
Medication: Paracetamol 0.5 0.9 2.1 -1.0 1.4 0.5 0.8 1.3 -0.3 -0.6
Headache pain in last month 0.5 0.8 2.2 0.6 -0.6 -0.7 -0.3 -0.2 1.4 1.5
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 6.0 -0.1 0.4 -2.4 1.2 0.7 1.8 0.8
Glaucoma (self-reported) 1.0 1.2 4.0 1.2 -2.0 -0.1 -1.1 -1.0 0.0 0.7
Gout (self-reported) 0.8 1.1 3.5 -1.3 1.0 1.9 0.4 0.8 -0.5 -0.6
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 2.5 -1.1 0.9 1.3 -0.5 0.3 -1.6 -0.7
Medication: Amlodipine 0.2 0.3 0.8 -0.4 0.4 0.3 -0.1 0.3 -0.8 -0.9
Medication: Ventolin 100micrograms inhaler 0.8 1.0 1.9 1.3 -1.2 0.6 -1.4 -1.0 -0.2 0.8
Birth weight 1.8 3.9 6.4 2.5 -1.9 2.1 -2.3 -2.0 -0.0 1.8
Chronic bronchitis/emphysema (mother) 2.3 2.7 4.6 -1.3 1.1 -1.7 2.0 1.9 2.1 0.8
High blood pressure (siblings) 1.3 1.9 3.9 2.0 -1.4 0.0 -1.9 -1.8 -0.8 0.5
Forced vital capacity (FVC), Best measure 1.3 4.6 10.1 2.4 -2.4 1.3 -2.7 -3.2 -0.7 1.1
Body fat percentage 1.4 5.6 9.1 -2.9 2.6 -1.7 3.0 2.9 0.4 -1.7
Leg fat percentage (right) 1.7 6.2 11.1 -2.9 2.8 -1.2 3.3 3.3 0.3 -2.1
Arm fat-free mass (right) 0.6 3.3 6.2 2.0 -2.1 1.4 -2.5 -2.1 -1.3 0.6
Exposure to tobacco smoke outside home 3.1 4.1 8.5 -2.2 1.9 -1.0 2.9 2.9 1.1 -1.2
Comparative body size at age 10 2.4 6.5 11.9 -3.1 3.5 1.6 2.8 3.2 -0.4 -1.8
Number of full brothers 0.9 1.1 3.9 -0.6 0.7 -0.5 1.4 2.0 0.8 0.1
Worry too long after embarrassment 0.3 0.5 0.9 0.8 -0.6 -1.0 -0.7 -0.5 0.2 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.9 -0.1 0.7 0.9 0.3 0.5 0.1 0.7
Wheeze or whistling in the chest in last year 1.0 1.8 3.6 -1.6 1.9 -1.0 1.7 1.3 0.9 0.1
Number of children fathered 0.5 0.6 1.6 1.3 -0.7 -0.0 -0.8 -0.7 -0.7 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.6 0.7 -0.5 0.3 -0.3 -0.4 0.9 1.2
Age at first live birth 0.1 0.1 0.6 0.1 -0.1 0.4 0.3 0.0 -0.1 -0.7
Pulse wave peak to peak time 2.5 2.9 6.8 2.6 -1.8 -0.7 -0.5 -0.7 2.0 2.2
Health satisfaction 0.3 0.4 0.8 -0.2 0.3 -0.9 0.2 0.6 -0.8 -0.8
Shortness of breath walking on level ground 6.6 7.8 13.3 -3.6 2.7 -2.1 3.5 3.6 0.3 -2.0
Qualifications: College or University degree 0.6 2.0 5.1 1.5 -1.4 0.5 -2.3 -1.8 -0.4 1.2
Eye problems/disorders: None of the above 1.0 1.1 2.6 -1.5 1.6 0.3 1.2 1.0 0.3 -0.5
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.6 -0.8 0.9 -0.5 1.1 1.3 0.3 -0.3
Emphysema/chronic bronchitis 0.2 0.2 0.8 -0.2 0.2 -0.9 0.6 0.5 0.4 0.2
Medication for pain relief, constipation, heartburn 1.7 2.9 5.3 1.8 -2.3 -0.9 -1.2 -1.7 1.7 2.0
Neck or shoulder pain in last month 0.2 0.4 0.7 -0.8 0.7 0.6 0.2 0.4 -0.4 -0.8
Medication: Blood pressure 1.4 2.5 6.8 0.0 -0.0 2.6 -1.4 -1.1 -2.4 -1.4
Angina (self-reported) 2.9 3.8 6.5 -2.1 2.5 1.1 2.0 2.3 -1.0 -1.9
Migraine (self-reported) 1.9 2.4 4.6 2.1 -1.7 -0.2 -1.5 -1.1 1.1 2.1
Medication: Ibuprofen 1.6 1.9 3.3 -1.7 1.8 1.5 0.9 0.9 -1.3 -1.4
Medication: Allopurinol 0.6 0.8 2.3 -1.1 0.7 1.5 0.5 0.8 -0.6 -0.7
Medication: Omeprazole 0.8 0.9 1.9 -0.9 1.4 -0.3 0.7 0.8 -1.0 -1.3
Medication: Seretide 50 evohaler 0.2 0.2 0.5 -0.2 -0.3 -0.6 0.2 0.5 0.7 0.6
Mean time to correctly identify matches 2.1 3.9 10.3 -1.9 1.8 1.1 0.9 1.1 -2.7 -3.2
Heart disease (mother) 0.2 0.2 1.0 -0.2 0.1 0.1 0.5 0.1 1.0 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.6 5.1 0.3 -1.4 -0.8 0.1 0.2 2.2 1.9
Whole body fat mass 0.3 1.4 2.1 -1.4 1.3 -0.7 1.4 1.4 -0.2 -1.1
Leg fat mass (right) 0.8 3.1 5.0 -2.1 2.0 -0.3 2.2 2.2 -0.3 -1.8
Arm predicted mass (right) 0.5 2.4 4.7 1.6 -1.8 1.5 -2.2 -1.7 -1.2 0.6
Pulse rate, automated reading 0.1 0.3 1.2 -0.0 -0.1 -1.1 0.1 -0.2 0.7 0.5
Alcohol intake frequency. 0.8 1.8 3.6 0.9 -1.5 -1.9 -0.3 -0.2 1.7 1.7
Comparative height size at age 10 5.1 28.1 53.6 5.5 -5.9 1.2 -7.3 -6.8 -0.0 5.5
Number of full sisters 2.7 3.3 6.0 -2.5 2.2 -0.3 2.0 2.1 -0.4 -1.7
Suffer from ‘nerves’ 0.1 0.1 0.3 -0.0 0.2 0.4 -0.2 -0.2 -0.5 0.2
Overall health rating 0.9 2.0 3.7 -1.8 1.0 1.4 0.3 0.9 -1.9 -1.8
Chest pain or discomfort 2.9 4.2 7.8 -2.1 2.8 -0.4 2.4 2.3 -1.0 -2.3
Had major operations 1.2 1.4 6.2 -0.4 0.0 2.5 -1.2 -0.6 -1.3 0.1
Age at last live birth 0.2 0.3 1.1 -0.1 0.5 0.3 0.3 0.2 -0.6 -1.1
Family relationship satisfaction 1.1 1.3 2.2 1.5 -1.2 -1.1 -1.5 -1.2 -0.5 0.8
Leg pain on walking 1.6 2.0 4.4 -2.1 1.2 0.6 1.1 1.8 -1.1 -1.5
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.6 -1.0 0.7 -0.1 1.3 0.6 0.4 -0.6
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.2 -0.4 0.7 -0.2 1.1 0.9 0.0 -1.0
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 3.1 1.8 -1.1 0.2 -1.3 -1.5 0.6 1.3
Medication: Aspirin 0.8 1.1 1.8 -1.3 1.3 0.4 0.5 0.8 -1.3 -1.3
Supplements: Vitamin C 0.7 0.9 1.6 -1.3 1.2 -1.0 0.8 1.1 -0.1 -0.5
Knee pain experienced in last month 0.8 1.3 4.5 -0.6 0.7 -2.1 0.9 1.2 1.0 0.1
Hypertension (Self-reported) 2.0 5.6 12.9 0.3 -0.9 3.6 -2.7 -1.9 -3.5 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 1.3 -0.5 0.2 -1.1 -0.1 0.3 -0.4 -0.2
Illnesses of father: Heart disease 0.5 0.8 2.0 -0.3 0.9 0.9 0.4 0.2 -1.1 -1.4
Illnesses of siblings: Diabetes 0.3 0.4 1.4 0.1 -0.4 -0.5 0.2 -0.1 1.2 0.9
Smoking status: Previous 2.3 3.4 6.9 2.1 -1.7 1.6 -2.6 -2.3 -0.4 1.3
Forced expiratory volume in 1-second (FEV1), predicted 1.9 3.9 7.7 2.1 -1.9 1.0 -2.8 -2.8 -0.9 1.5
Whole body fat-free mass 0.7 4.1 8.1 2.2 -2.1 1.6 -2.9 -2.4 -1.4 0.9
Leg fat-free mass (right) 0.5 2.6 5.0 1.7 -1.5 1.5 -2.2 -1.9 -1.2 0.6
Arm fat percentage (left) 1.7 6.7 11.4 -3.0 3.0 -1.6 3.4 3.3 0.2 -2.0
Average weekly red wine intake 4.9 7.2 13.2 3.6 -2.9 1.0 -3.4 -3.5 -0.4 2.0
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.1 1.0 -0.7 -0.1 -0.5 -1.0 -0.6 0.0
Mood swings 2.5 4.6 10.0 1.7 -2.1 1.3 -3.2 -2.6 -2.5 -0.1
Loneliness, isolation 0.1 0.2 1.1 -0.3 -0.1 -1.1 0.1 0.1 0.3 0.3
Long-standing illness, disability or infirmity 0.3 0.5 1.0 -1.0 0.9 0.9 0.1 0.8 -0.7 -0.2
Ever had bowel cancer screening 1.5 1.7 3.0 -1.0 0.9 -1.4 1.6 1.5 1.7 0.7
Diabetes diagnosed by doctor 0.1 0.2 0.5 -0.7 0.4 -0.2 0.2 0.7 0.5 0.4
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 2.2 -0.2 1.1 -0.8 1.5 1.2 1.5 0.6
Friendships satisfaction 1.4 1.7 3.8 1.5 -1.9 -0.7 -1.4 -1.4 0.2 1.1
Qualifications: nursing, teaching 1.2 1.8 6.3 0.4 -0.4 -2.5 0.2 0.1 2.1 1.3
Commuting to job workplace: Walk 0.6 0.7 1.5 0.6 -0.3 1.2 -1.2 -0.8 -0.7 0.5
Eye problems/disorders: Cataract 0.6 0.7 1.5 0.8 -1.2 1.0 -0.8 -0.6 -0.8 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 3.2 0.2 -1.2 -1.8 -1.1 -0.9 0.6 1.2
Medication for cholesterol 0.7 1.1 3.1 -0.3 0.5 1.6 -0.5 -0.3 -1.8 -1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.9 -0.9 0.9 0.5 0.9 1.0 0.2 -0.1
Back pain experienced in last month 2.3 3.3 6.6 -2.0 2.1 -0.9 2.6 2.5 1.0 -0.7
Mineral and other dietary supplements 2.5 3.4 6.3 2.3 -2.0 1.4 -2.2 -2.5 -0.4 1.1
Breast cancer (self-reported) 1.4 1.7 3.1 1.2 -1.2 -0.5 -1.5 -1.5 0.9 1.8
Asthma (self-reported) 1.0 2.0 4.3 1.4 -1.4 1.2 -2.1 -1.7 -0.6 1.1
Osteoporosis (self-reported) 0.2 0.2 0.7 -0.0 -0.5 -0.2 -0.2 -0.2 0.7 0.9
Osteoarthritis (self-reported) 0.2 0.3 0.8 -0.3 0.5 0.6 -0.6 -0.2 -0.9 -0.5
Medication: Aspirin 0.8 1.0 3.0 -0.8 1.1 0.9 0.0 0.3 -1.7 -1.2
Medication: Gliclazide 0.1 0.1 0.5 -0.3 -0.3 -0.6 0.0 0.7 0.2 -0.1
Illnesses of father: None of the above (group 1) 0.8 1.0 2.7 -0.7 0.5 -1.7 1.3 0.8 1.1 0.1
Smoking status: Current 1.1 1.8 3.3 -1.3 1.2 -1.6 1.8 1.5 1.1 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.5 0.4 -1.0 1.2 -0.4 -0.5 -0.3 -0.4
Whole body water mass 0.8 4.6 9.0 2.4 -2.3 1.7 -3.0 -2.5 -1.4 1.0
Leg predicted mass (right) 0.5 2.6 5.0 1.6 -1.4 1.6 -2.2 -1.9 -1.3 0.5
Arm fat mass (left) 0.6 2.3 4.2 -1.6 1.7 -1.1 2.0 2.0 0.3 -1.1
Number of self-reported non-cancer illnesses 0.2 0.4 1.1 0.3 -0.6 0.7 -1.1 -0.2 -0.7 0.3
Average weekly champagne plus white wine intake 0.2 0.2 0.6 -0.2 0.4 0.8 -0.1 -0.4 -0.4 -0.6
Miserableness 0.4 0.6 1.1 0.8 -0.6 -0.7 -1.0 -1.0 -1.0 0.0
Guilty feelings 0.7 1.0 3.3 0.4 -0.7 0.1 -1.2 -1.0 -1.8 -0.8
Wears glasses or contact lenses 1.6 1.9 3.9 1.6 -1.3 1.1 -2.0 -1.5 -0.3 1.2
Ever taken oral contraceptive pill 0.4 0.4 0.8 0.9 -0.3 -0.7 -0.5 -0.7 0.6 0.6
Hearing aid user 0.2 0.2 1.2 -0.1 0.1 1.1 -0.2 -0.0 -0.3 0.1
Mother’s age at death 0.1 0.2 0.7 -0.8 0.2 0.3 0.1 0.3 -0.1 -0.4
Financial situation satisfaction 1.5 1.8 7.0 -0.1 -0.1 1.1 -0.4 -0.2 -2.6 -2.0
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.1 -1.0 0.1 0.9 0.3 1.0 -0.6 -0.6
Commuting to job workplace: Public transport 0.6 0.7 1.2 -1.1 0.9 0.6 0.6 1.1 -0.5 -0.7
Eye problems/disorders: Glaucoma 1.1 1.3 3.2 1.6 -1.8 -0.4 -1.2 -1.2 -0.1 0.6
Medication: Blood pressure 0.2 0.5 1.8 -0.3 0.2 1.3 -0.4 -0.1 -0.9 -0.5
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.5 -1.2 1.1 1.1 0.2 0.4 -1.1 -0.8
Supplements: Fish oil (including cod liver oil) 3.3 4.4 7.8 -2.5 2.4 -1.0 2.8 2.7 0.4 -1.7
High cholesterol (Self-reported) 0.3 0.6 2.0 0.3 -0.9 0.4 0.5 0.3 1.4 0.6
Medication: Bendroflumethiazide 0.1 0.1 0.3 0.3 0.5 0.2 -0.3 -0.5 0.0 0.2
Medication: Paracetamol 0.2 0.3 0.9 -0.3 0.9 0.5 0.3 0.7 -0.1 -0.0
Medication: Lisinopril 3.6 4.7 9.4 2.6 -1.9 1.4 -3.0 -3.1 -1.2 0.8
Medication: Atorvastatin 0.2 0.2 0.8 0.4 0.1 0.5 -0.2 -0.3 0.3 0.9
Illnesses of father: High blood pressure 2.6 3.2 7.3 1.8 -1.7 1.8 -2.7 -1.7 -1.0 1.3
Alcohol drinker status: Never 1.3 1.5 4.0 2.0 -1.3 -0.8 -1.1 -1.1 0.5 1.3
Ever smoked 0.2 0.4 1.1 0.4 -0.0 -0.2 -0.9 -0.7 0.1 1.1
Basal metabolic rate 0.5 2.5 5.0 1.8 -1.6 1.2 -2.2 -1.8 -1.1 0.8
Leg fat percentage (left) 1.5 5.5 8.8 -2.9 2.6 -0.8 3.0 2.9 -0.1 -2.2
Arm fat-free mass (left) 0.4 2.1 4.2 1.5 -1.6 1.3 -2.1 -1.6 -1.2 0.6
Number of operations (self-reported) 0.3 0.4 1.8 0.3 -0.5 0.3 -0.8 -0.2 0.5 1.3
Average weekly beer plus cider intake 1.6 2.4 5.8 -1.3 2.0 0.6 2.4 1.9 0.7 -1.0
Irritability 5.2 8.7 18.0 2.9 -3.5 0.0 -4.2 -4.1 -0.7 2.3
Risk taking 2.3 3.3 11.3 -0.1 0.5 -3.4 1.2 1.1 2.5 1.8
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.4 -0.4 0.2 -1.0 1.1 1.1 1.5 0.5
Fractured/broken bones in last 5 years 3.2 4.2 5.8 -2.3 1.8 1.8 1.4 2.3 -2.1 -2.4
Age started oral contraceptive pill 0.1 0.2 1.0 0.4 -0.2 -1.0 -0.2 0.2 0.0 -0.2
Diastolic blood pressure, automated reading 0.3 0.8 2.3 1.0 0.0 0.4 0.2 -0.0 -1.5 -1.4
Ever depressed for a whole week 0.6 0.8 1.9 -1.4 1.0 0.3 0.1 0.7 -1.2 -0.7
Unable to work because of sickness or disability 0.5 0.6 1.3 -0.5 0.6 -0.4 1.2 1.0 1.1 0.3
Commuting to job workplace: Cycle 0.0 0.1 0.2 -0.3 -0.1 -0.4 -0.0 -0.1 -0.2 0.2
Myopia 0.2 0.3 1.1 0.7 -0.6 0.1 -0.7 -1.0 0.0 0.2
Vascular/heart problems diagnosed by doctor 2.1 5.8 16.7 -0.0 0.5 -4.1 2.5 1.6 3.5 1.4
Cholesterol lowering medication 0.8 1.2 3.0 -0.8 0.7 -0.0 1.7 1.4 1.4 0.2
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 1.0 -0.4 1.0 -0.5 0.4 0.4 -0.5 -0.5
Pain experienced in last month 0.1 0.1 0.4 0.4 0.0 -0.1 -0.4 -0.6 -0.5 -0.3
Supplements: Calcium 0.4 0.5 1.2 0.1 -0.7 0.6 -1.1 -1.0 -0.0 0.6
Basal cell carcinoma (self-reported) 0.3 0.4 0.8 -0.4 0.1 0.9 0.3 0.6 -0.8 -0.8
Heart attack/myocardial infarction (self-reported) 0.8 1.0 1.7 -1.1 1.2 1.1 0.3 0.2 -1.2 -1.3
Deep venous thrombosis (DVT) (self-reported) 6.4 8.2 13.3 -3.6 3.6 -0.7 3.2 3.1 -1.0 -3.0
Heart disease (siblings) 0.0 0.0 0.1 -0.2 -0.1 -0.3 0.0 0.2 0.2 0.3
Alcohol drinker status: Previous 0.4 0.5 3.1 0.1 -0.1 -1.8 0.2 0.5 0.3 0.0
Pack years of smoking 1.4 2.0 4.9 -2.0 2.2 0.9 1.3 1.5 -0.2 -0.3
Impedance of whole body 0.2 1.3 4.4 -0.0 -0.5 -2.1 -0.6 -0.9 1.2 1.4
Leg fat mass (left) 0.6 2.4 3.8 -2.0 1.8 -0.1 1.8 1.9 -0.5 -1.7
Arm predicted mass (left) 0.4 2.0 3.9 1.4 -1.4 1.4 -2.0 -1.5 -1.3 0.4