TWAS hub - ZNF585A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0850	0.0280	3.6e-10	0.095	0.093	0.110	0.098	0.110	1.2e-11	1.9e-11	2.8e-13	5.7e-12	2.6e-13
2	GTEx	Adipose Subcutaneous	0.0920	0.0450	8.9e-04	0.022	NA	0.020	NA	0.025	5.8e-03	NA	8.4e-03	NA	3.8e-03
3	GTEx	Cells Transformed fibroblasts	0.0640	0.0350	2.8e-03	0.035	NA	0.014	NA	0.031	1.1e-03	NA	3.1e-02	NA	2.0e-03
4	GTEx	Nerve Tibial	0.0633	0.0281	2.1e-04	0.074	NA	0.044	NA	0.057	6.0e-06	NA	4.4e-04	NA	6.9e-05
5	GTEx	Spleen	0.2310	0.1030	1.3e-03	0.095	NA	0.074	NA	0.074	2.0e-03	NA	6.0e-03	NA	5.9e-03
6	TCGA	Bladder Urothelial Carcinoma	0.0370	0.0230	8.6e-03	0.013	0.015	0.013	NA	0.014	2.4e-02	1.8e-02	2.6e-02	NA	2.3e-02
7	TCGA	Colon Adenocarcinoma	0.0830	0.0500	5.3e-04	0.060	0.053	0.046	NA	0.048	2.4e-04	5.0e-04	1.2e-03	NA	9.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Blood clot in the leg (DVT)	6.8	8.7	14.4	-3.7	3.8	-0.6	3.3	3.2	-1.1	-3.2
Shortness of breath walking on level ground	6.6	7.8	13.3	-3.6	2.7	-2.1	3.5	3.6	0.3	-2.0
Deep venous thrombosis (DVT) (self-reported)	6.4	8.2	13.3	-3.6	3.6	-0.7	3.2	3.1	-1.0	-3.0
Multivitamins +/- minerals	5.7	7.2	14.2	-3.2	3.8	-0.1	3.3	3.5	-0.1	-1.6
Pulse wave reflection index	5.5	6.8	13.2	-3.6	3.3	0.0	2.6	2.4	-1.2	-2.9
Hand grip strength (left)	5.2	13.6	23.0	4.8	-4.7	1.0	-4.1	-4.5	1.2	3.2
Irritability	5.2	8.7	18.0	2.9	-3.5	0.0	-4.2	-4.1	-0.7	2.3
Primary Biliary Cirrhosis	5.1	7.3	13.5	3.4	-3.7	-1.2	-2.5	-3.3	1.3	2.4
Comparative height size at age 10	5.1	28.1	53.6	5.5	-5.9	1.2	-7.3	-6.8	-0.0	5.5
Average weekly red wine intake	4.9	7.2	13.2	3.6	-2.9	1.0	-3.4	-3.5	-0.4	2.0
Crohns Disease (2017)	4.8	10.6	19.8	3.7	-3.9	1.2	-4.4	-4.2	-0.2	2.4
Crohns Disease (2012)	4.7	7.6	14.4	3.5	-3.5	0.8	-3.4	-3.8	-0.8	1.1
Vitamin and mineral supplements	4.6	6.3	13.1	3.4	-3.6	-0.2	-2.5	-2.9	0.9	1.9
Hand grip strength (right)	4.6	12.5	21.3	4.6	-4.6	1.2	-3.9	-4.2	1.1	3.0
Height	4.5	86.4	148.8	11.0	-11.1	1.5	-12.2	-11.8	-0.3	8.4
Happiness	4.4	5.4	11.5	2.5	-2.8	0.6	-3.4	-2.9	-1.0	1.7
Falls in the last year	3.8	5.1	9.2	-2.5	3.0	-0.6	3.0	3.0	0.4	-1.4
Medication: Lisinopril	3.6	4.7	9.4	2.6	-1.9	1.4	-3.0	-3.1	-1.2	0.8
Reaction Time	3.4	6.5	14.4	-2.6	3.1	0.9	2.0	1.7	-2.6	-3.8
Blood Eosinophil Count	3.3	25.4	41.3	6.4	-6.3	-0.3	-5.8	-5.6	1.7	5.3
Sitting height	3.3	23.6	44.2	5.6	-5.6	1.2	-6.6	-5.9	-0.3	4.7
Supplements: Fish oil (including cod liver oil)	3.3	4.4	7.8	-2.5	2.4	-1.0	2.8	2.7	0.4	-1.7
Fractured/broken bones in last 5 years	3.2	4.2	5.8	-2.3	1.8	1.8	1.4	2.3	-2.1	-2.4
Exposure to tobacco smoke outside home	3.1	4.1	8.5	-2.2	1.9	-1.0	2.9	2.9	1.1	-1.2
Qualifications: CSEs or equivalent	2.9	3.8	7.1	-2.1	2.2	-0.6	2.7	2.3	-0.3	-2.2
Tense / ‘highly strung’	2.9	4.7	10.1	1.8	-2.7	0.6	-3.2	-2.7	-0.4	2.1
Angina (self-reported)	2.9	3.8	6.5	-2.1	2.5	1.1	2.0	2.3	-1.0	-1.9
Chest pain or discomfort	2.9	4.2	7.8	-2.1	2.8	-0.4	2.4	2.3	-1.0	-2.3
Standing height	2.8	28.0	55.5	5.7	-5.9	1.4	-7.5	-7.0	-0.9	4.6
Systolic Blood Pressure	2.7	13.8	24.2	3.5	-3.1	4.0	-4.6	-4.9	-3.6	-0.1
Alcohol usually taken with meals	2.7	4.3	9.3	2.0	-2.6	0.7	-3.0	-2.8	-0.6	1.4
Number of full sisters	2.7	3.3	6.0	-2.5	2.2	-0.3	2.0	2.1	-0.4	-1.7
Irritable Bowel Disease (IBD)	2.6	6.1	14.0	2.3	-2.8	0.6	-3.7	-3.4	-0.9	1.6
Illnesses of father: High blood pressure	2.6	3.2	7.3	1.8	-1.7	1.8	-2.7	-1.7	-1.0	1.3
Lung FEV1/FVC ratio	2.5	12.7	20.5	-3.6	3.6	3.5	2.9	3.3	-3.2	-4.5
Pulse wave peak to peak time	2.5	2.9	6.8	2.6	-1.8	-0.7	-0.5	-0.7	2.0	2.2
Mood swings	2.5	4.6	10.0	1.7	-2.1	1.3	-3.2	-2.6	-2.5	-0.1
Mineral and other dietary supplements	2.5	3.4	6.3	2.3	-2.0	1.4	-2.2	-2.5	-0.4	1.1
High blood pressure (mother)	2.4	3.4	7.3	1.3	-1.1	2.1	-2.5	-1.7	-2.7	-0.3
Comparative body size at age 10	2.4	6.5	11.9	-3.1	3.5	1.6	2.8	3.2	-0.4	-1.8
HbA1C	2.3	2.6	5.1	2.3	-1.8	-0.8	-0.8	-1.4	1.8	1.8
Chronic bronchitis/emphysema (mother)	2.3	2.7	4.6	-1.3	1.1	-1.7	2.0	1.9	2.1	0.8
Smoking status: Previous	2.3	3.4	6.9	2.1	-1.7	1.6	-2.6	-2.3	-0.4	1.3
Back pain experienced in last month	2.3	3.3	6.6	-2.0	2.1	-0.9	2.6	2.5	1.0	-0.7
Risk taking	2.3	3.3	11.3	-0.1	0.5	-3.4	1.2	1.1	2.5	1.8
Lupus	2.2	3.3	10.0	0.0	0.5	2.7	-1.7	-1.1	-3.2	-1.3
Hearing difficulty/problems: Yes	2.2	3.4	6.1	-2.5	2.3	-0.0	2.0	1.8	-0.9	-1.9
Angina	2.2	2.9	5.0	-1.8	2.2	1.2	1.7	2.0	-1.0	-1.7
Townsend deprivation index at recruitment	2.2	3.1	6.9	1.5	-1.2	-1.6	-0.7	-1.5	2.4	2.6
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	4.8	-2.2	1.2	1.2	0.5	0.5	-1.9	-2.0
Medication: Ramipril	2.1	2.7	4.0	-1.7	1.8	1.6	0.8	1.4	-1.7	-2.0
Mean time to correctly identify matches	2.1	3.9	10.3	-1.9	1.8	1.1	0.9	1.1	-2.7	-3.2
Vascular/heart problems diagnosed by doctor	2.1	5.8	16.7	-0.0	0.5	-4.1	2.5	1.6	3.5	1.4
Medication: Co-codamol	2.0	2.3	6.7	0.2	-0.6	-2.6	0.8	1.1	2.3	1.4
Had menopause	2.0	2.5	5.9	1.3	-1.2	1.4	-2.4	-1.6	-1.9	-0.1
Hypertension (Self-reported)	2.0	5.6	12.9	0.3	-0.9	3.6	-2.7	-1.9	-3.5	-1.5
Ovarian Cancer	1.9	2.6	3.9	1.5	-1.9	-2.0	-0.8	-1.6	1.7	1.4
Migraine (self-reported)	1.9	2.4	4.6	2.1	-1.7	-0.2	-1.5	-1.1	1.1	2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.9	7.7	2.1	-1.9	1.0	-2.8	-2.8	-0.9	1.5
Breast Cancer	1.8	4.3	9.4	-3.1	2.8	-0.4	2.4	2.1	-0.1	-1.6
Type 2 Diabetes (T2D) (2012)	1.8	2.1	4.0	1.7	-2.0	-0.1	-1.7	-1.5	0.3	1.6
Diabetes (mother)	1.8	2.3	3.8	1.9	-1.8	0.3	-1.6	-1.5	0.6	1.9
Relative age voice broke	1.8	2.8	5.0	-1.3	1.5	-2.2	2.2	1.9	1.6	-0.4
High blood pressure	1.8	5.0	12.1	0.0	-0.6	3.5	-2.4	-1.5	-3.5	-1.5
Birth weight of first child	1.8	3.2	6.6	2.6	-1.8	-0.5	-1.2	-0.7	1.9	2.5
Birth weight	1.8	3.9	6.4	2.5	-1.9	2.1	-2.3	-2.0	-0.0	1.8
Bipolar Disorder (2011)	1.7	1.6	4.1	-0.7	1.3	-1.2	2.0	1.3	1.4	-0.5
Neuroticism score	1.7	3.6	9.2	1.4	-1.9	0.0	-3.0	-2.4	-2.0	0.8
Arm fat percentage (right)	1.7	6.9	12.0	-2.9	3.1	-1.6	3.5	3.4	0.4	-1.9
Illnesses of mother	1.7	2.1	3.9	-1.6	1.6	-1.3	2.0	1.6	0.6	-0.9
Leg fat percentage (right)	1.7	6.2	11.1	-2.9	2.8	-1.2	3.3	3.3	0.3	-2.1
Medication for pain relief, constipation, heartburn	1.7	2.9	5.3	1.8	-2.3	-0.9	-1.2	-1.7	1.7	2.0
Arm fat percentage (left)	1.7	6.7	11.4	-3.0	3.0	-1.6	3.4	3.3	0.2	-2.0
Loud music exposure frequency	1.6	1.8	4.2	-0.8	1.0	1.6	0.3	0.6	-1.9	-2.1
Medication: Ibuprofen	1.6	1.9	3.3	-1.7	1.8	1.5	0.9	0.9	-1.3	-1.4
Leg pain on walking	1.6	2.0	4.4	-2.1	1.2	0.6	1.1	1.8	-1.1	-1.5
Wears glasses or contact lenses	1.6	1.9	3.9	1.6	-1.3	1.1	-2.0	-1.5	-0.3	1.2
Average weekly beer plus cider intake	1.6	2.4	5.8	-1.3	2.0	0.6	2.4	1.9	0.7	-1.0
Allergy or Eczema	1.5	3.9	7.3	1.6	-2.7	-1.7	-1.7	-1.4	1.9	2.5
Hayfever, allergic rhinitis or eczema	1.5	3.2	6.4	1.8	-2.5	-1.0	-1.9	-1.7	1.2	2.1
Pulse wave Arterial Stiffness index	1.5	1.8	4.2	-1.9	1.1	0.9	-0.4	-0.0	-2.0	-1.6
Ever had bowel cancer screening	1.5	1.7	3.0	-1.0	0.9	-1.4	1.6	1.5	1.7	0.7
Financial situation satisfaction	1.5	1.8	7.0	-0.1	-0.1	1.1	-0.4	-0.2	-2.6	-2.0
Leg fat percentage (left)	1.5	5.5	8.8	-2.9	2.6	-0.8	3.0	2.9	-0.1	-2.2
Pack years adult smoking proportion	1.4	2.2	5.4	-1.9	2.3	1.0	1.5	1.6	-0.2	-0.4
Maternal smoking around birth	1.4	2.1	4.4	-1.5	1.6	-2.1	1.6	1.5	0.9	0.1
Waist circumference	1.4	5.2	8.2	-2.9	2.2	-2.2	2.8	2.9	0.4	-1.4
Number of incorrect matches in round	1.4	2.4	4.7	1.3	-2.0	-0.3	-2.2	-1.9	0.1	1.5
Hair/balding pattern: Pattern 2	1.4	1.7	4.6	-0.8	0.7	2.0	-0.8	-0.4	-2.1	-1.2
Body fat percentage	1.4	5.6	9.1	-2.9	2.6	-1.7	3.0	2.9	0.4	-1.7
Medication: Blood pressure	1.4	2.5	6.8	0.0	-0.0	2.6	-1.4	-1.1	-2.4	-1.4
Friendships satisfaction	1.4	1.7	3.8	1.5	-1.9	-0.7	-1.4	-1.4	0.2	1.1
Breast cancer (self-reported)	1.4	1.7	3.1	1.2	-1.2	-0.5	-1.5	-1.5	0.9	1.8
Pack years of smoking	1.4	2.0	4.9	-2.0	2.2	0.9	1.3	1.5	-0.2	-0.3
Neuroticism (Nagel 2018)	1.3	3.0	7.3	1.5	-2.0	0.2	-2.7	-2.1	-1.6	0.7
Alzheimer’s Disease (in mother)	1.3	1.5	2.9	1.7	-1.3	-0.2	-1.3	-1.3	0.6	1.4
Alzheimer’s Disease (in father)	1.3	1.4	3.0	-1.0	1.7	0.0	1.1	1.4	-1.1	-1.4
Verbal and Numeric Reasoning (VNR)	1.3	3.2	5.7	-1.7	2.4	1.6	0.9	1.1	-2.1	-2.2
Prostate Cancer	1.3	1.9	6.1	0.5	-0.5	-2.5	1.0	0.3	2.0	1.2
Respiratory disease	1.3	2.8	6.0	1.8	-1.7	0.0	-2.4	-2.1	-0.2	1.7
Neuroticism	1.3	3.0	8.0	1.0	-1.8	0.4	-2.8	-1.9	-2.2	0.5
Systolic blood pressure, automated reading	1.3	3.8	5.3	1.9	-1.7	2.3	-2.2	-2.3	-2.2	-0.4
Serious illness, injury or assault to yourself	1.3	1.6	6.3	-0.2	0.4	-2.5	1.0	1.1	1.4	0.7
Nervous feelings	1.3	2.5	5.3	1.3	-1.5	0.0	-2.2	-2.3	0.1	1.7
Fluid intelligence score	1.3	2.7	4.9	-1.4	1.9	2.0	0.3	0.9	-2.2	-1.9
Exposure to tobacco smoke at home	1.3	1.4	2.2	-1.4	0.8	1.2	0.8	1.1	-1.3	-1.5
High blood pressure (siblings)	1.3	1.9	3.9	2.0	-1.4	0.0	-1.9	-1.8	-0.8	0.5
Forced vital capacity (FVC), Best measure	1.3	4.6	10.1	2.4	-2.4	1.3	-2.7	-3.2	-0.7	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	5.1	0.3	-1.4	-0.8	0.1	0.2	2.2	1.9
Alcohol drinker status: Never	1.3	1.5	4.0	2.0	-1.3	-0.8	-1.1	-1.1	0.5	1.3
Age at First Birth	1.2	1.7	3.3	1.0	-1.8	1.4	-1.5	-1.5	-1.0	-0.0
Blood Platelet Count	1.2	13.7	24.1	-3.1	4.4	1.6	4.5	4.9	-1.7	-4.1
Waist Hip Ratio (WHR)	1.2	5.5	9.0	-2.7	2.1	-3.0	2.9	2.8	1.2	-0.7
Cardiovascular Disease	1.2	4.1	13.5	0.2	-0.7	3.7	-1.8	-1.4	-2.7	-1.3
Sensitivity / hurt feelings	1.2	2.0	5.2	-2.3	1.5	0.3	1.0	1.3	-1.5	-1.3
Medication for hormone replacement therapy	1.2	1.4	5.8	-0.1	0.1	-2.4	0.5	0.8	1.3	1.2
Current tobacco smoking	1.2	2.0	4.1	-1.3	1.4	-1.5	2.0	1.7	1.1	0.0
Trunk fat-free mass	1.2	6.6	13.1	3.0	-2.8	1.6	-3.6	-3.0	-1.4	1.5
Trunk predicted mass	1.2	6.7	13.3	3.0	-2.8	1.7	-3.6	-3.1	-1.4	1.5
Peak expiratory flow (PEF)	1.2	2.8	6.7	0.8	-2.0	2.6	-1.9	-2.0	-0.5	0.5
Had major operations	1.2	1.4	6.2	-0.4	0.0	2.5	-1.2	-0.6	-1.3	0.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.1	1.8	-1.1	0.2	-1.3	-1.5	0.6	1.3
Qualifications: nursing, teaching	1.2	1.8	6.3	0.4	-0.4	-2.5	0.2	0.1	2.1	1.3
Worry (Nagel 2018)	1.1	2.2	6.1	0.9	-1.5	0.5	-2.5	-1.9	-1.3	1.0
Supplements: Glucosamine	1.1	1.4	3.0	-1.6	1.7	-0.9	1.1	1.6	0.1	-0.3
Medication: Levothyroxine sodium	1.1	1.9	4.1	-1.5	1.6	1.5	-0.1	0.7	-2.0	-1.5
Body mass index (BMI)	1.1	4.7	9.5	-2.2	2.3	-0.8	3.0	3.1	0.2	-1.8
Forced vital capacity (FVC)	1.1	4.2	8.9	2.2	-2.3	1.7	-2.5	-3.0	-0.9	0.8
Worrier / anxious feelings	1.1	2.1	9.1	0.1	0.0	1.0	-1.4	-1.0	-3.0	-1.1
Hair/balding pattern: Pattern 3	1.1	1.7	4.2	-2.0	0.8	0.1	1.3	1.6	-0.6	-1.5
Medication: Lansoprazole	1.1	1.3	4.1	-0.5	0.7	-2.0	1.1	1.0	1.4	0.5
Family relationship satisfaction	1.1	1.3	2.2	1.5	-1.2	-1.1	-1.5	-1.2	-0.5	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.2	-0.2	1.1	-0.8	1.5	1.2	1.5	0.6
Smoking status: Current	1.1	1.8	3.3	-1.3	1.2	-1.6	1.8	1.5	1.1	0.1
Eye problems/disorders: Glaucoma	1.1	1.3	3.2	1.6	-1.8	-0.4	-1.2	-1.2	-0.1	0.6
Depressed Affect (Nagel 2018)	1.0	2.0	4.5	1.5	-1.8	-0.7	-2.1	-1.6	-1.1	0.5
Intelligence (Savage-Jansen 2018)	1.0	3.0	5.8	-1.1	2.4	1.7	0.7	0.8	-2.4	-2.1
Coronary Artery Disease (CAD)	1.0	1.2	3.9	-0.3	0.5	-0.5	0.3	0.3	-2.0	-1.9
HDL Cholesterol	1.0	1.7	3.1	1.1	-1.4	0.5	-1.4	-1.4	1.1	1.8
Rheumatoid Arthritis	1.0	1.4	3.1	-1.8	1.3	0.1	1.0	1.4	-0.8	-1.0
Trunk fat percentage	1.0	4.2	6.4	-2.4	2.2	-2.0	2.5	2.5	0.7	-1.1
Fed-up feelings	1.0	1.8	3.9	0.8	-0.9	-1.3	-2.0	-1.4	-1.9	0.1
Had other major operations	1.0	1.3	3.5	0.6	-0.9	-1.3	-0.9	-0.7	1.0	1.9
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.1	0.8	-1.4	-0.1	-1.8	-1.4	-1.1	0.3
Number of live births	1.0	1.3	2.5	-1.3	1.1	-1.5	1.0	1.6	-0.2	-0.8
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	6.0	-0.1	0.4	-2.4	1.2	0.7	1.8	0.8
Glaucoma (self-reported)	1.0	1.2	4.0	1.2	-2.0	-0.1	-1.1	-1.0	0.0	0.7
Wheeze or whistling in the chest in last year	1.0	1.8	3.6	-1.6	1.9	-1.0	1.7	1.3	0.9	0.1
Eye problems/disorders: None of the above	1.0	1.1	2.6	-1.5	1.6	0.3	1.2	1.0	0.3	-0.5
Asthma (self-reported)	1.0	2.0	4.3	1.4	-1.4	1.2	-2.1	-1.7	-0.6	1.1
Triglycerides	0.9	1.4	9.1	-0.2	-0.5	-3.0	0.6	0.0	0.5	-0.1
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.0	-1.2	1.4	0.4	0.4	0.8	-1.4	-1.2
Medication: Cholesterol lowering	0.9	1.4	7.4	-0.4	0.3	2.7	-0.2	-0.0	-1.2	-0.9
Number of full brothers	0.9	1.1	3.9	-0.6	0.7	-0.5	1.4	2.0	0.8	0.1
Overall health rating	0.9	2.0	3.7	-1.8	1.0	1.4	0.3	0.9	-1.9	-1.8
BMI	0.8	4.8	8.8	-2.5	2.5	-0.1	3.0	2.8	-0.2	-2.2
Average weekly spirits intake	0.8	1.0	1.8	1.3	-1.1	0.3	-1.3	-1.2	0.2	1.0
Average weekly fortified wine intake	0.8	0.9	3.3	-0.2	-0.1	-1.8	0.9	0.7	1.2	0.6
Heart attack	0.8	1.1	1.8	-1.3	1.3	0.8	0.6	0.5	-1.0	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.1	0.3	-0.7	1.8	-0.9	-0.6	-1.1	-0.6
Asthma	0.8	1.6	3.2	1.1	-1.0	1.5	-1.8	-1.4	-0.7	0.9
Depression (self-reported)	0.8	0.9	2.0	-0.5	0.4	-1.4	0.6	0.5	1.4	1.3
Gout (self-reported)	0.8	1.1	3.5	-1.3	1.0	1.9	0.4	0.8	-0.5	-0.6
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.9	1.3	-1.2	0.6	-1.4	-1.0	-0.2	0.8
Medication: Omeprazole	0.8	0.9	1.9	-0.9	1.4	-0.3	0.7	0.8	-1.0	-1.3
Leg fat mass (right)	0.8	3.1	5.0	-2.1	2.0	-0.3	2.2	2.2	-0.3	-1.8
Alcohol intake frequency.	0.8	1.8	3.6	0.9	-1.5	-1.9	-0.3	-0.2	1.7	1.7
Medication: Aspirin	0.8	1.1	1.8	-1.3	1.3	0.4	0.5	0.8	-1.3	-1.3
Knee pain experienced in last month	0.8	1.3	4.5	-0.6	0.7	-2.1	0.9	1.2	1.0	0.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	3.2	0.2	-1.2	-1.8	-1.1	-0.9	0.6	1.2
Medication: Aspirin	0.8	1.0	3.0	-0.8	1.1	0.9	0.0	0.3	-1.7	-1.2
Illnesses of father: None of the above (group 1)	0.8	1.0	2.7	-0.7	0.5	-1.7	1.3	0.8	1.1	0.1
Whole body water mass	0.8	4.6	9.0	2.4	-2.3	1.7	-3.0	-2.5	-1.4	1.0
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.4	-0.4	0.2	-1.0	1.1	1.1	1.5	0.5
Cholesterol lowering medication	0.8	1.2	3.0	-0.8	0.7	-0.0	1.7	1.4	1.4	0.2
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.7	-1.1	1.2	1.1	0.3	0.2	-1.2	-1.3
Depression (Nagel 2018)	0.7	1.0	4.5	-0.0	-1.2	-2.1	0.1	0.1	0.7	0.6
Blood White Count	0.7	5.5	9.9	-2.1	2.4	-0.3	3.1	3.1	-0.7	-2.8
Age when periods started (menarche)	0.7	1.8	2.9	-1.2	0.7	-1.4	1.7	1.6	-0.2	-1.6
Past tobacco smoking	0.7	1.3	2.9	-1.1	0.8	-0.8	1.7	1.4	0.1	-1.3
Financial difficulties in last 2 years	0.7	1.0	2.3	-0.6	0.6	-1.1	0.7	0.7	-1.4	-1.5
Father’s age at death	0.7	1.0	2.2	0.7	-0.4	0.9	-1.5	-1.5	-1.0	0.3
Lung cancer (father)	0.7	0.8	1.1	-1.0	1.0	0.4	0.9	1.1	-0.9	-1.1
Arm fat mass (right)	0.7	2.9	5.4	-1.8	2.0	-1.0	2.3	2.3	0.3	-1.2
Supplements: Vitamin C	0.7	0.9	1.6	-1.3	1.2	-1.0	0.8	1.1	-0.1	-0.5
Whole body fat-free mass	0.7	4.1	8.1	2.2	-2.1	1.6	-2.9	-2.4	-1.4	0.9
Medication for cholesterol	0.7	1.1	3.1	-0.3	0.5	1.6	-0.5	-0.3	-1.8	-1.2
Guilty feelings	0.7	1.0	3.3	0.4	-0.7	0.1	-1.2	-1.0	-1.8	-0.8
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.5	-1.2	1.1	1.1	0.2	0.4	-1.1	-0.8
Major Depression (MDD)	0.6	0.8	4.0	-0.4	-0.6	-2.0	-0.1	-0.1	0.7	0.6
Neuroticism (2016)	0.6	0.9	2.1	0.4	-1.4	-0.9	-1.2	-0.4	0.4	1.3
Chronotype (morning person)	0.6	1.3	2.8	1.1	-0.9	1.7	-1.2	-0.8	0.6	1.5
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.1	0.8	-0.8	0.1	-1.5	-0.8	-0.4	0.8
Severe depression (siblings)	0.6	0.7	2.9	-0.3	0.6	0.6	-0.2	-0.4	-1.7	-1.0
Alcohol intake versus 10 years previously	0.6	1.0	3.5	-0.8	0.8	1.9	0.1	0.2	-0.9	-1.0
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	6.5	0.5	-0.5	2.5	-1.0	-1.4	-1.6	-0.8
Noisy workplace	0.6	0.7	1.7	-1.3	0.9	0.2	0.9	0.8	-0.1	-0.9
Mouth/teeth dental problems: Dentures	0.6	1.0	2.4	-0.5	0.5	-1.0	0.9	1.2	1.5	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.3	-1.1	1.1	0.9	0.3	0.2	-1.0	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	4.6	1.0	-0.9	2.2	-1.3	-1.8	-1.3	-0.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.7	0.2	-0.4	1.3	-1.1	-1.3	-0.7	0.1
Arm fat-free mass (right)	0.6	3.3	6.2	2.0	-2.1	1.4	-2.5	-2.1	-1.3	0.6
Qualifications: College or University degree	0.6	2.0	5.1	1.5	-1.4	0.5	-2.3	-1.8	-0.4	1.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.6	-0.8	0.9	-0.5	1.1	1.3	0.3	-0.3
Medication: Allopurinol	0.6	0.8	2.3	-1.1	0.7	1.5	0.5	0.8	-0.6	-0.7
Commuting to job workplace: Walk	0.6	0.7	1.5	0.6	-0.3	1.2	-1.2	-0.8	-0.7	0.5
Eye problems/disorders: Cataract	0.6	0.7	1.5	0.8	-1.2	1.0	-0.8	-0.6	-0.8	-0.4
Arm fat mass (left)	0.6	2.3	4.2	-1.6	1.7	-1.1	2.0	2.0	0.3	-1.1
Commuting to job workplace: Public transport	0.6	0.7	1.2	-1.1	0.9	0.6	0.6	1.1	-0.5	-0.7
Ever depressed for a whole week	0.6	0.8	1.9	-1.4	1.0	0.3	0.1	0.7	-1.2	-0.7
Leg fat mass (left)	0.6	2.4	3.8	-2.0	1.8	-0.1	1.8	1.9	-0.5	-1.7
Mean Putamen Volume	0.5	0.6	2.5	0.2	0.6	0.6	0.5	0.1	-0.8	-1.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	3.5	-0.1	-0.8	-1.9	-0.4	-0.1	0.1	0.5
Relative age of first facial hair	0.5	1.1	2.3	0.4	-1.0	-1.3	-0.5	-0.4	1.4	1.5
Ever had hysterectomy (womb removed)	0.5	0.6	1.7	0.7	-0.6	-0.2	0.4	0.7	1.3	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	4.3	0.1	-0.1	-1.2	1.0	0.3	2.1	1.0
Stomach or abdominal pain in last month	0.5	0.6	1.3	0.6	-1.2	-0.5	-1.1	-0.7	-0.3	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.0	3.5	0.0	0.4	-1.4	1.0	0.4	1.9	0.8
Allergy	0.5	1.2	2.4	-0.8	1.4	1.1	0.8	0.8	-1.1	-1.5
Pain all over the body in last month	0.5	0.6	1.6	-0.5	0.5	0.5	0.6	0.4	-1.0	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.6	-0.9	0.5	-1.3	0.7	1.1	-0.7	-0.7
Length of working week for main job	0.5	0.6	1.8	-1.3	0.6	-0.7	0.6	0.6	-0.4	-0.7
Medication: Paracetamol	0.5	0.9	2.1	-1.0	1.4	0.5	0.8	1.3	-0.3	-0.6
Headache pain in last month	0.5	0.8	2.2	0.6	-0.6	-0.7	-0.3	-0.2	1.4	1.5
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.5	-1.1	0.9	1.3	-0.5	0.3	-1.6	-0.7
Number of children fathered	0.5	0.6	1.6	1.3	-0.7	-0.0	-0.8	-0.7	-0.7	-0.2
Arm predicted mass (right)	0.5	2.4	4.7	1.6	-1.8	1.5	-2.2	-1.7	-1.2	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.6	-1.0	0.7	-0.1	1.3	0.6	0.4	-0.6
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.2	-0.4	0.7	-0.2	1.1	0.9	0.0	-1.0
Illnesses of father: Heart disease	0.5	0.8	2.0	-0.3	0.9	0.9	0.4	0.2	-1.1	-1.4
Leg fat-free mass (right)	0.5	2.6	5.0	1.7	-1.5	1.5	-2.2	-1.9	-1.2	0.6
Leg predicted mass (right)	0.5	2.6	5.0	1.6	-1.4	1.6	-2.2	-1.9	-1.3	0.5
Basal metabolic rate	0.5	2.5	5.0	1.8	-1.6	1.2	-2.2	-1.8	-1.1	0.8
Unable to work because of sickness or disability	0.5	0.6	1.3	-0.5	0.6	-0.4	1.2	1.0	1.1	0.3
Hypothyroidism (self reported)	0.4	0.9	1.6	-1.1	0.8	1.3	-1.1	-0.2	-1.3	0.1
Tanning	0.4	5.0	11.3	-1.3	2.2	-2.3	3.4	2.6	2.3	0.2
Medication: Metformin	0.4	0.5	1.6	-1.3	0.9	-0.1	0.5	0.7	0.6	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	3.2	-0.1	-0.9	-1.8	-0.0	-0.1	-0.1	-0.1
Taking other prescription medications	0.4	0.7	2.4	-0.5	-0.0	0.8	-1.0	-0.4	-1.6	-0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.2	0.2	-0.4	-0.0	-1.1	-1.0	-0.8	-0.1
Leg predicted mass (left)	0.4	1.9	3.6	1.4	-1.1	1.5	-1.9	-1.6	-1.4	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.0	-0.8	0.1	-0.6	-0.6	-0.3	-1.4	-0.7
Medication: Simvastatin	0.4	0.7	1.2	-0.8	-0.1	1.1	0.9	1.1	0.8	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.6	0.7	-0.5	0.3	-0.3	-0.4	0.9	1.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	1.0	-0.7	-0.1	-0.5	-1.0	-0.6	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.9	-0.9	0.9	0.5	0.9	1.0	0.2	-0.1
Miserableness	0.4	0.6	1.1	0.8	-0.6	-0.7	-1.0	-1.0	-1.0	0.0
Ever taken oral contraceptive pill	0.4	0.4	0.8	0.9	-0.3	-0.7	-0.5	-0.7	0.6	0.6
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.1	-1.0	0.1	0.9	0.3	1.0	-0.6	-0.6
Arm fat-free mass (left)	0.4	2.1	4.2	1.5	-1.6	1.3	-2.1	-1.6	-1.2	0.6
Supplements: Calcium	0.4	0.5	1.2	0.1	-0.7	0.6	-1.1	-1.0	-0.0	0.6
Alcohol drinker status: Previous	0.4	0.5	3.1	0.1	-0.1	-1.8	0.2	0.5	0.3	0.0
Arm predicted mass (left)	0.4	2.0	3.9	1.4	-1.4	1.4	-2.0	-1.5	-1.3	0.4
Ulcerative Colitis (UC)	0.3	0.6	1.6	0.3	-0.7	-0.3	-1.3	-1.1	-0.7	0.3
Body Mass Index (BMI) (2010)	0.3	0.5	1.3	-0.5	0.5	-1.1	0.7	0.5	0.7	0.3
Blood Red Count	0.3	3.2	9.6	-2.0	1.7	0.7	1.8	0.9	-1.1	-3.1
Hair Pigment	0.3	7.5	11.6	2.9	-3.4	-2.1	-2.1	-2.3	2.7	3.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.2	-0.9	0.4	0.1	0.5	1.1	-0.2	-0.5
Leg fat-free mass (left)	0.3	1.9	3.5	1.4	-1.1	1.5	-1.9	-1.5	-1.3	0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.0	0.4	-0.1	-0.6	0.0	0.1	1.0	0.9
Trunk fat mass	0.3	1.2	2.1	-1.4	1.3	-1.0	1.2	1.4	-0.0	-0.8
Qualifications: None of the above	0.3	0.7	1.7	-0.2	-0.6	-1.2	0.5	0.7	1.3	0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.6	1.0	-1.0	-1.3	-0.9	-0.2	0.5	0.8
Prospective memory result	0.3	0.3	0.9	-0.4	0.1	0.5	0.9	0.6	0.3	-0.8
Impedance of arm (left)	0.3	1.4	4.3	0.2	-0.4	-2.1	-0.8	-1.0	1.1	1.5
Breastfed as a baby	0.3	0.4	0.7	0.6	0.2	-0.8	0.9	0.7	0.2	-0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.7	0.1	0.4	0.3	-0.9	-0.8	-1.3	-0.5
Worry too long after embarrassment	0.3	0.5	0.9	0.8	-0.6	-1.0	-0.7	-0.5	0.2	0.9
Health satisfaction	0.3	0.4	0.8	-0.2	0.3	-0.9	0.2	0.6	-0.8	-0.8
Whole body fat mass	0.3	1.4	2.1	-1.4	1.3	-0.7	1.4	1.4	-0.2	-1.1
Illnesses of siblings: Diabetes	0.3	0.4	1.4	0.1	-0.4	-0.5	0.2	-0.1	1.2	0.9
Long-standing illness, disability or infirmity	0.3	0.5	1.0	-1.0	0.9	0.9	0.1	0.8	-0.7	-0.2
High cholesterol (Self-reported)	0.3	0.6	2.0	0.3	-0.9	0.4	0.5	0.3	1.4	0.6
Number of operations (self-reported)	0.3	0.4	1.8	0.3	-0.5	0.3	-0.8	-0.2	0.5	1.3
Diastolic blood pressure, automated reading	0.3	0.8	2.3	1.0	0.0	0.4	0.2	-0.0	-1.5	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.0	-0.4	1.0	-0.5	0.4	0.4	-0.5	-0.5
Basal cell carcinoma (self-reported)	0.3	0.4	0.8	-0.4	0.1	0.9	0.3	0.6	-0.8	-0.8
Bipolar Disorder (2018)	0.2	0.4	0.9	0.6	0.0	-0.9	0.8	0.1	0.9	0.2
Bipolar Disorder or Schizophrenia	0.2	0.6	1.4	0.2	0.6	-1.0	1.2	0.3	1.1	0.1
Schizophrenia (2018)	0.2	0.3	0.8	-0.3	0.7	-0.6	0.9	0.2	0.7	-0.0
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	0.3	-0.3	0.6	-0.7	-0.4	-0.6	0.2
Ulcerative Colitis	0.2	0.3	0.8	0.1	-0.5	-0.5	-0.9	-0.4	-0.6	0.1
Lung FVC	0.2	0.9	2.5	-1.0	0.7	-0.8	1.6	0.9	0.8	-0.8
Supplements: Zinc	0.2	0.2	0.5	0.6	0.2	-0.7	-0.3	-0.5	-0.5	0.0
Impedance of leg (right)	0.2	0.9	3.2	-0.2	-0.4	-1.8	-0.1	-0.4	1.2	1.1
Impedance of leg (left)	0.2	0.9	3.2	-0.3	-0.5	-1.8	-0.3	-0.6	1.1	1.0
Hearing difficulty/problems with background noise	0.2	0.3	0.7	-0.8	0.4	0.8	0.2	0.5	-0.2	-0.1
Mouth/teeth dental problems	0.2	0.3	0.5	0.7	-0.4	0.6	-0.3	-0.6	-0.6	-0.4
Illnesses of siblings	0.2	0.2	0.9	-0.2	0.0	-0.3	0.5	0.3	0.9	0.5
Impedance of arm (right)	0.2	1.1	3.3	0.4	-0.3	-1.8	-0.6	-0.9	1.1	1.4
Pulse rate	0.2	0.3	0.7	-0.5	0.2	0.0	-0.2	-0.1	-0.9	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.6	0.9	0.6	0.1	0.4	-0.9	-0.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.7	0.6	-0.9	0.2	-0.5	-0.4	-0.5	0.1
Medication: Amlodipine	0.2	0.3	0.8	-0.4	0.4	0.3	-0.1	0.3	-0.8	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.9	-0.1	0.7	0.9	0.3	0.5	0.1	0.7
Emphysema/chronic bronchitis	0.2	0.2	0.8	-0.2	0.2	-0.9	0.6	0.5	0.4	0.2
Neck or shoulder pain in last month	0.2	0.4	0.7	-0.8	0.7	0.6	0.2	0.4	-0.4	-0.8
Medication: Seretide 50 evohaler	0.2	0.2	0.5	-0.2	-0.3	-0.6	0.2	0.5	0.7	0.6
Heart disease (mother)	0.2	0.2	1.0	-0.2	0.1	0.1	0.5	0.1	1.0	0.4
Age at last live birth	0.2	0.3	1.1	-0.1	0.5	0.3	0.3	0.2	-0.6	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.3	-0.5	0.2	-1.1	-0.1	0.3	-0.4	-0.2
Osteoporosis (self-reported)	0.2	0.2	0.7	-0.0	-0.5	-0.2	-0.2	-0.2	0.7	0.9
Osteoarthritis (self-reported)	0.2	0.3	0.8	-0.3	0.5	0.6	-0.6	-0.2	-0.9	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.5	0.4	-1.0	1.2	-0.4	-0.5	-0.3	-0.4
Number of self-reported non-cancer illnesses	0.2	0.4	1.1	0.3	-0.6	0.7	-1.1	-0.2	-0.7	0.3
Average weekly champagne plus white wine intake	0.2	0.2	0.6	-0.2	0.4	0.8	-0.1	-0.4	-0.4	-0.6
Hearing aid user	0.2	0.2	1.2	-0.1	0.1	1.1	-0.2	-0.0	-0.3	0.1
Medication: Blood pressure	0.2	0.5	1.8	-0.3	0.2	1.3	-0.4	-0.1	-0.9	-0.5
Medication: Paracetamol	0.2	0.3	0.9	-0.3	0.9	0.5	0.3	0.7	-0.1	-0.0
Medication: Atorvastatin	0.2	0.2	0.8	0.4	0.1	0.5	-0.2	-0.3	0.3	0.9
Ever smoked	0.2	0.4	1.1	0.4	-0.0	-0.2	-0.9	-0.7	0.1	1.1
Myopia	0.2	0.3	1.1	0.7	-0.6	0.1	-0.7	-1.0	0.0	0.2
Impedance of whole body	0.2	1.3	4.4	-0.0	-0.5	-2.1	-0.6	-0.9	1.2	1.4
Fasting Glucose	0.1	0.1	0.3	0.6	-0.0	-0.6	-0.1	-0.5	-0.1	-0.1
LDL Cholesterol	0.1	0.1	0.4	-0.3	0.0	0.6	0.3	0.1	-0.3	-0.1
Smoking Status	0.1	0.3	0.5	0.7	0.3	0.7	-0.5	-0.4	0.2	0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	-0.7	-0.1	0.8	-0.2	0.2	0.2	0.4
Number of treatments/medications taken	0.1	0.2	0.5	-0.7	0.1	0.5	-0.4	0.0	-0.4	0.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.1	0.1	0.2	0.4	-0.0	0.5	-0.2
Diabetes (father)	0.1	0.1	0.2	-0.3	-0.2	0.2	0.0	0.1	0.5	0.3
Medication: Atenolol	0.1	0.1	0.3	-0.1	0.5	0.6	0.1	0.3	0.1	-0.0
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.5	-0.3	0.4	0.4	0.3	0.0	-0.3
Diabetes (self-reported)	0.1	0.1	0.4	-0.6	0.1	0.5	0.1	0.4	0.3	0.3
Time employed in main current job	0.1	0.1	0.2	-0.3	0.1	-0.5	0.4	0.0	-0.0	-0.4
Hair/balding pattern: Pattern 4	0.1	0.3	1.1	0.2	0.9	1.1	0.3	0.1	-0.1	-0.3
Age at first live birth	0.1	0.1	0.6	0.1	-0.1	0.4	0.3	0.0	-0.1	-0.7
Pulse rate, automated reading	0.1	0.3	1.2	-0.0	-0.1	-1.1	0.1	-0.2	0.7	0.5
Suffer from ‘nerves’	0.1	0.1	0.3	-0.0	0.2	0.4	-0.2	-0.2	-0.5	0.2
Loneliness, isolation	0.1	0.2	1.1	-0.3	-0.1	-1.1	0.1	0.1	0.3	0.3
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.7	0.4	-0.2	0.2	0.7	0.5	0.4
Medication: Gliclazide	0.1	0.1	0.5	-0.3	-0.3	-0.6	0.0	0.7	0.2	-0.1
Mother’s age at death	0.1	0.2	0.7	-0.8	0.2	0.3	0.1	0.3	-0.1	-0.4
Medication: Bendroflumethiazide	0.1	0.1	0.3	0.3	0.5	0.2	-0.3	-0.5	0.0	0.2
Age started oral contraceptive pill	0.1	0.2	1.0	0.4	-0.2	-1.0	-0.2	0.2	0.0	-0.2
Pain experienced in last month	0.1	0.1	0.4	0.4	0.0	-0.1	-0.4	-0.6	-0.5	-0.3
Alzheimer’s Disease (including proxy)	0.0	0.1	0.2	0.4	0.2	0.2	0.0	0.3	-0.1	0.1
Schizophrenia (2014)	0.0	0.1	0.3	0.3	0.2	-0.5	0.0	-0.5	0.1	0.3
Heel T-Score	0.0	0.4	0.9	-0.4	-0.3	0.8	-0.1	-0.2	-0.8	-1.0
Weight	0.0	0.1	0.2	0.3	-0.3	-0.2	-0.4	-0.1	-0.2	0.3
Hip circumference	0.0	0.2	1.1	-0.1	-0.1	-1.0	-0.0	0.0	-0.3	-0.2
Commuting to job workplace: Cycle	0.0	0.1	0.2	-0.3	-0.1	-0.4	-0.0	-0.1	-0.2	0.2
Heart disease (siblings)	0.0	0.0	0.1	-0.2	-0.1	-0.3	0.0	0.2	0.2	0.3

Hub : Genes

ZNF585A

Models

Trait associations