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chr19:56,320,200-59,095,126

Best TWAS P=3.8e-10 · Best GWAS P=1e-08 conditioned to 0.109

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	AC007228.11	0.10	0.04	lasso	5	0.06	2.2e-05	4.2	5.2	1.6e-07	0.86	0.02	0.98	FALSE
2	GTEx	Adipose Visceral Omentum	AC007228.11	0.14	0.04	lasso	6	0.06	6.9e-04	5.7	5.7	1.2e-08	0.90	0.01	0.98	FALSE
3	GTEx	Artery Aorta	AC007228.11	0.31	0.22	enet	24	0.23	6.5e-13	5.7	6.1	8.2e-10	0.90	0.00	1.00	FALSE
4	GTEx	Artery Coronary	AC007228.11	0.30	0.15	lasso	6	0.10	2.1e-04	5.2	5.8	7.1e-09	0.95	0.01	0.98	FALSE
5	GTEx	Artery Tibial	AC007228.11	0.17	0.14	lasso	5	0.14	1.8e-11	5.0	5.3	1.2e-07	0.93	0.02	0.98	FALSE
6	GTEx	Brain Cerebellum	ZNF471	0.24	0.25	enet	14	0.20	1.2e-06	4.2	-5.1	2.8e-07	-0.68	0.15	0.80	FALSE
7	GTEx	Brain Cerebellum	AC007228.11	0.62	0.40	lasso	11	0.54	9.5e-19	5.1	5.7	1.5e-08	0.85	0.01	0.99	FALSE
8	GTEx	Brain Hypothalamus	AC007228.11	0.39	0.24	lasso	6	0.22	8.8e-06	5.7	5.9	4.4e-09	0.96	0.01	0.98	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	AC007228.11	0.46	0.26	lasso	5	0.11	6.1e-04	-4.2	5.5	4.0e-08	0.88	0.01	0.99	FALSE
10	GTEx	Breast Mammary Tissue	ZNF71	0.14	0.13	lasso	3	0.11	1.9e-06	-4.9	5.1	2.8e-07	0.34	0.22	0.75	FALSE
11	GTEx	Breast Mammary Tissue	AC007228.11	0.22	0.14	lasso	5	0.14	7.4e-08	5.1	5.3	1.1e-07	0.92	0.01	0.99	FALSE
12	GTEx	Colon Sigmoid	ZNF471	0.30	0.10	lasso	4	0.07	1.5e-03	4.2	-5.2	2.5e-07	-0.84	0.02	0.93	FALSE
13	GTEx	Colon Sigmoid	AC007228.11	0.21	0.19	lasso	3	0.15	7.9e-06	5.7	5.7	9.4e-09	1.00	0.01	0.99	FALSE
14	GTEx	Colon Transverse	AC007228.11	0.19	0.17	lasso	7	0.18	4.7e-09	5.1	5.5	2.9e-08	0.95	0.01	0.99	FALSE
15	GTEx	Esophagus Mucosa	ZFP28	0.13	0.09	lasso	5	0.06	5.9e-05	5.2	5.3	1.4e-07	0.93	0.01	0.98	FALSE
16	GTEx	Esophagus Mucosa	ZNF470	0.18	0.05	enet	14	0.05	2.8e-04	-5.2	5.1	3.1e-07	0.31	0.11	0.83	FALSE
17	GTEx	Esophagus Mucosa	AC007228.11	0.12	0.10	lasso	5	0.08	3.6e-06	4.9	5.4	6.9e-08	0.89	0.02	0.98	FALSE
18	GTEx	Lung	AC007228.11	0.12	0.07	enet	8	0.05	7.0e-05	5.7	5.5	2.8e-08	0.97	0.00	0.99	FALSE
19	GTEx	Muscle Skeletal	AC007228.11	0.11	0.05	enet	14	0.06	1.6e-06	5.1	5.3	1.0e-07	0.85	0.02	0.97	FALSE
20	GTEx	Nerve Tibial	AC007228.11	0.17	0.14	lasso	5	0.14	5.2e-10	5.7	5.6	2.2e-08	0.98	0.00	1.00	FALSE
21	GTEx	Ovary	AC007228.11	0.29	0.04	lasso	7	0.12	6.6e-04	5.7	5.7	1.6e-08	0.92	0.01	0.89	FALSE
22	GTEx	Pituitary	AC007228.11	0.40	0.29	lasso	4	0.28	1.3e-07	5.0	5.4	7.0e-08	0.95	0.01	0.99	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	ZFP28	0.24	0.16	lasso	7	0.18	5.5e-10	5.2	5.4	5.8e-08	0.95	0.01	0.99	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	AC007228.11	0.22	0.01	lasso	6	0.03	8.9e-03	4.9	5.7	9.5e-09	0.90	0.01	0.99	FALSE
25	GTEx	Skin Sun Exposed Lower leg	ZNF417	0.22	0.07	enet	48	0.11	3.0e-09	-4.0	5.7	1.5e-08	0.01	0.13	0.62	TRUE
26	GTEx	Skin Sun Exposed Lower leg	ZNF749	0.16	0.10	lasso	3	0.11	3.3e-09	4.5	5.2	2.2e-07	-0.06	0.01	0.98	TRUE
27	GTEx	Skin Sun Exposed Lower leg	ZNF471	0.15	0.09	lasso	4	0.08	2.8e-07	5.1	-5.2	2.0e-07	-0.68	0.10	0.90	FALSE
28	GTEx	Skin Sun Exposed Lower leg	ZFP28	0.19	0.13	lasso	9	0.17	1.1e-13	5.7	6.2	6.5e-10	0.93	0.01	0.99	FALSE
29	GTEx	Spleen	AC007228.11	0.25	0.08	enet	23	0.07	6.0e-03	-4.9	5.9	3.4e-09	0.72	0.04	0.83	FALSE
30	GTEx	Stomach	AC007228.11	0.14	0.11	lasso	4	0.07	3.8e-04	5.0	5.4	6.2e-08	0.95	0.01	0.99	FALSE
31	GTEx	Thyroid	AC007228.11	0.28	0.22	lasso	8	0.23	3.1e-17	5.7	5.7	1.4e-08	0.97	0.00	1.00	FALSE
32	GTEx	Whole Blood	ZFP28	0.11	0.10	enet	12	0.09	2.5e-08	4.9	5.4	7.1e-08	0.80	0.16	0.84	FALSE
33	GTEx	Whole Blood	AC007228.11	0.11	0.01	lasso	5	0.00	2.1e-01	5.7	5.6	1.7e-08	0.98	0.01	0.95	FALSE
34	METSIM	Adipose	ZFP28	0.13	0.09	bslmm	490	0.12	7.3e-17	5.2	6.3	3.8e-10	0.79	0.01	0.99	TRUE
35	NTR	Blood	ZFP28	0.06	0.05	lasso	7	0.06	1.3e-18	-4.9	5.8	6.6e-09	0.48	0.26	0.74	FALSE
36	YFS	Blood	ZFP28	0.03	0.03	lasso	4	0.03	6.5e-09	4.9	5.4	6.0e-08	0.87	0.08	0.92	FALSE
37	YFS	Blood	ZNF470	0.04	0.02	bslmm	476	0.02	3.4e-07	-4.9	5.4	6.7e-08	0.55	0.16	0.84	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF470	0.05	0.05	lasso	3	0.05	4.0e-10	-4.9	5.2	1.8e-07	0.37	0.18	0.81	FALSE
39	The Cancer Genome Atlas	Colon Adenocarcinoma	ZNF470	0.05	0.02	blup	73	0.04	3.1e-03	-4.3	6.2	4.8e-10	0.70	0.03	0.52	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF470	0.06	0.02	blup	72	0.03	1.8e-04	-4.9	5.7	9.9e-09	0.61	0.11	0.88	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZFP28	0.03	0.02	enet	5	0.02	1.1e-03	-4.2	5.3	1.1e-07	0.76	0.03	0.73	FALSE
42	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ZNF470	0.10	0.07	lasso	3	0.08	3.3e-04	-4.9	5.2	2.4e-07	0.37	0.07	0.48	FALSE
43	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZNF71	0.07	0.05	blup	78	0.02	1.6e-02	-4.3	5.3	1.4e-07	0.48	0.02	0.90	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF71	0.05	0.01	enet	6	0.02	1.9e-03	5.0	5.5	5.0e-08	0.78	0.01	0.90	FALSE