Best TWAS P=6.67e-10 · Best GWAS P=5.58e-10 conditioned to 7.9e-06
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | FAM210B | 0.31 | 0.10 | enet | 11 | 0.11 | 1.6e-09 | 5.7 | -6.1 | 1.1e-09 | -0.31 | 0.09 | 0.91 | FALSE |
2 | GTEx | Artery Tibial | FAM210B | 0.19 | 0.10 | enet | 11 | 0.11 | 1.1e-08 | 5.4 | -6.2 | 6.7e-10 | -0.32 | 0.09 | 0.91 | TRUE |
3 | GTEx | Cells Transformed fibroblasts | FAM210B | 0.09 | 0.05 | lasso | 3 | 0.04 | 4.1e-04 | 5.5 | -5.7 | 1.1e-08 | -0.29 | 0.08 | 0.86 | FALSE |
4 | GTEx | Skin Sun Exposed Lower leg | FAM210B | 0.11 | 0.06 | lasso | 2 | 0.03 | 1.2e-03 | 5.4 | -5.5 | 4.2e-08 | -0.29 | 0.09 | 0.87 | FALSE |
5 | METSIM | Adipose | FAM210B | 0.14 | 0.06 | enet | 15 | 0.14 | 8.2e-20 | 4.2 | -5.8 | 6.7e-09 | -0.33 | 0.47 | 0.53 | FALSE |
6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AURKA | 0.04 | 0.03 | enet | 14 | 0.03 | 5.0e-04 | 5.5 | -5.2 | 2.0e-07 | -0.23 | 0.02 | 0.83 | FALSE |