TWAS hub - FAM210B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.305	0.0670	3.2e-07	0.102	NA	0.113	NA	0.104	1.1e-08	NA	1.6e-09	NA	7.9e-09
2	GTEx	Artery Tibial	0.192	0.0509	1.7e-05	0.096	NA	0.106	NA	0.105	6.3e-08	NA	1.1e-08	NA	1.3e-08
3	GTEx	Cells Transformed fibroblasts	0.088	0.0370	4.9e-03	0.050	NA	0.023	NA	0.042	1.3e-04	NA	6.7e-03	NA	4.1e-04
4	GTEx	Lung	0.141	0.0490	3.9e-03	0.055	NA	0.011	NA	0.032	4.7e-05	NA	4.8e-02	NA	1.5e-03
5	GTEx	Skin Sun Exposed Lower leg	0.114	0.0400	2.5e-03	0.063	NA	0.024	NA	0.031	6.4e-06	NA	4.2e-03	NA	1.2e-03
6	GTEx	Testis	0.233	0.0800	2.8e-03	-0.003	NA	-0.006	NA	-0.006	4.5e-01	NA	8.2e-01	NA	8.4e-01
7	METSIM	Adipose	0.140	0.0303	3.4e-09	0.065	0.076	0.136	0.104	0.112	5.2e-10	1.5e-11	8.2e-20	2.8e-15	2.0e-16

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Ever had hysterectomy (womb removed)	6.3	7.2	12.6	3.4	3.0	3.5	0.8	3.5	-0.1	2.1
Other serious medical condition/disability diagnosed by doctor	4.7	6.1	8.8	-2.9	-3.0	-2.7	-1.7	-2.7	0.8	-2.7
Forced expiratory volume in 1-second (FEV1), predicted	4.7	9.7	15.1	-3.9	-3.8	-3.7	-1.8	-3.4	-0.7	-3.0
Alzheimer’s Disease (in father)	4.4	4.8	9.4	2.6	2.4	2.3	1.1	2.1	-0.7	3.1
Length of working week for main job	4.0	4.4	7.3	-2.3	-2.2	-1.8	-2.3	-1.4	-1.8	-2.7
Age when periods started (menarche)	3.8	9.2	18.4	-3.6	-3.4	-4.3	-0.7	-4.0	-0.9	-2.1
Peak expiratory flow (PEF)	3.7	8.6	11.4	-3.3	-3.4	-3.3	-2.6	-3.2	0.4	-3.1
Ever had bowel cancer screening	3.7	4.3	7.9	2.8	2.5	2.3	0.7	2.1	-0.2	2.4
Trunk fat-free mass	3.6	20.7	33.6	-5.0	-5.2	-4.1	-4.4	-4.4	-2.1	-5.8
Leg predicted mass (right)	3.6	19.0	30.5	-4.8	-4.9	-3.9	-4.0	-4.2	-2.5	-5.5
Trunk predicted mass	3.5	20.3	32.8	-4.9	-5.1	-4.1	-4.3	-4.4	-2.1	-5.7
Whole body fat-free mass	3.5	20.2	33.3	-4.9	-5.1	-4.0	-4.2	-4.3	-2.3	-5.8
Leg fat-free mass (right)	3.5	18.8	30.2	-4.8	-4.9	-3.9	-4.0	-4.2	-2.5	-5.5
Neck or shoulder pain in last month	3.4	4.8	7.4	2.7	2.6	2.7	-0.1	2.6	0.8	2.1
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.6	7.8	-2.1	-2.4	-2.4	0.4	-2.8	-0.5	-0.8
Whole body water mass	3.4	19.1	31.7	-4.8	-4.9	-3.9	-4.1	-4.2	-2.3	-5.6
Medication: Aspirin	3.3	4.3	7.7	1.8	2.4	1.7	2.8	1.4	-1.3	2.6
Leg fat-free mass (left)	3.1	16.4	26.7	-4.5	-4.6	-3.6	-3.6	-3.9	-2.4	-5.2
Nervous feelings	3.1	5.7	12.1	2.0	2.3	1.9	3.5	1.7	2.0	2.8
Loneliness, isolation	3.1	4.3	15.6	1.4	1.4	1.0	4.0	1.0	1.6	2.4
Leg predicted mass (left)	3.0	16.0	26.0	-4.4	-4.5	-3.5	-3.6	-3.9	-2.4	-5.1
Basal metabolic rate	3.0	16.5	25.7	-4.5	-4.6	-3.7	-3.5	-4.0	-2.4	-5.1
Relative age of first facial hair	2.9	5.9	14.8	-2.7	-2.8	-3.9	0.5	-3.1	-0.0	-1.3
Standing height	2.9	28.4	38.1	-6.1	-6.2	-5.7	-4.5	-5.5	-2.8	-5.8
Medication: Lisinopril	2.9	3.8	7.7	2.1	2.1	1.8	2.1	1.3	-0.9	2.8
Irritability	2.9	4.8	10.9	1.9	2.0	1.9	3.3	1.4	1.9	2.5
Arm fat-free mass (right)	2.8	14.3	22.7	-4.1	-4.2	-3.3	-3.5	-3.7	-2.4	-4.8
Arm predicted mass (right)	2.8	14.5	22.4	-4.1	-4.3	-3.2	-3.7	-3.7	-2.4	-4.7
Comparative height size at age 10	2.8	15.6	23.7	-4.5	-4.9	-3.3	-4.3	-3.6	-1.1	-4.6
Medication: Aspirin	2.7	3.5	7.1	1.5	2.2	1.4	2.7	1.1	-1.0	2.5
Arm predicted mass (left)	2.7	13.6	22.9	-3.9	-4.1	-3.0	-3.8	-3.3	-2.4	-4.8
Depression (self-reported)	2.6	3.1	5.8	1.7	1.6	1.5	2.2	1.6	0.8	2.4
Serious illness, injury or assault to yourself	2.4	2.9	4.8	-2.2	-2.0	-2.0	0.1	-2.1	0.5	-1.6
Medication: Cholesterol lowering	2.3	3.5	5.9	2.4	2.4	2.2	1.3	1.9	0.3	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.3	7.4	11.9	-3.4	-3.3	-3.4	-1.3	-3.2	-1.2	-1.9
Osteoarthritis (self-reported)	2.3	3.0	5.1	1.8	1.8	1.7	1.9	1.3	-1.2	2.2
Alcohol drinker status: Never	2.3	2.7	3.8	-1.9	-1.9	-1.6	-1.5	-1.4	1.5	-1.7
Arm fat-free mass (left)	2.3	11.8	19.4	-3.7	-3.9	-3.0	-3.1	-3.3	-2.1	-4.4
Worry (Nagel 2018)	2.2	4.6	7.5	2.0	2.4	2.2	2.4	1.9	0.9	2.7
Height	2.2	41.8	57.6	-7.4	-7.6	-6.9	-4.7	-6.8	-4.4	-6.7
Neuroticism score	2.2	4.6	12.0	1.4	1.8	1.4	3.5	1.2	2.5	2.3
Forced expiratory volume in 1-second (FEV1)	2.2	7.5	11.2	-3.3	-3.3	-3.1	-2.2	-2.9	-0.8	-2.6
Suffer from ‘nerves’	2.2	3.5	8.6	1.4	1.8	0.9	2.8	1.4	-0.0	2.9
Mother’s age at death	2.2	2.8	4.0	2.0	2.0	1.6	1.6	1.8	0.4	1.7
Neuroticism (2016)	2.1	3.0	5.0	1.7	1.5	1.4	1.9	1.1	2.2	2.2
Forced vital capacity (FVC)	2.1	7.9	12.1	-3.4	-3.5	-2.9	-2.7	-2.7	-0.9	-2.8
Forced vital capacity (FVC), Best measure	2.1	7.5	12.4	-3.5	-3.4	-3.2	-1.8	-3.0	-1.4	-2.1
Townsend deprivation index at recruitment	2.0	2.8	12.0	1.5	1.2	1.3	0.0	1.2	3.5	0.7
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.4	1.9	1.6	2.1	0.2	2.1	-0.7	1.1
Medication: Blood pressure	2.0	3.5	5.1	2.2	2.1	2.3	1.4	2.0	1.3	1.4
Mood swings	2.0	3.7	6.2	1.3	1.7	1.4	2.5	0.9	2.5	2.5
Neuroticism (Nagel 2018)	1.9	4.5	11.7	1.7	2.0	1.8	3.4	1.3	1.1	2.6
Alzheimer’s Disease (including proxy)	1.9	2.7	6.2	1.7	1.7	1.9	-0.1	1.7	-0.0	2.5
Frequency of depressed mood in last 2 weeks	1.9	2.7	7.1	1.1	1.0	1.1	1.9	1.1	2.7	1.9
Neuroticism	1.8	4.2	12.9	1.3	1.8	1.3	3.6	1.0	1.8	2.4
Sitting height	1.8	12.8	18.7	-4.2	-4.3	-3.6	-3.4	-3.2	-1.3	-4.1
Pain all over the body in last month	1.8	1.9	6.1	-0.9	-0.8	-1.4	2.5	-1.2	1.5	0.8
Loud music exposure frequency	1.8	1.9	3.8	-1.5	-1.6	-1.2	-0.8	-1.1	1.1	-1.9
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	4.8	-2.2	-2.1	-2.1	-1.0	-1.7	-1.4	-1.2
High cholesterol (Self-reported)	1.8	3.2	6.0	1.6	1.9	1.5	2.5	1.3	-1.4	2.1
Depressed Affect (Nagel 2018)	1.7	3.5	9.8	1.4	1.9	1.4	3.1	1.1	0.8	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	8.8	0.3	0.5	0.3	3.0	-0.0	1.4	2.0
Hayfever, allergic rhinitis or eczema	1.7	3.6	6.2	2.1	2.5	1.8	1.7	1.7	1.1	2.2
Sensitivity / hurt feelings	1.6	2.7	8.9	1.2	1.2	1.4	1.7	1.4	3.0	0.8
Ever highly irritable/argumentative for 2 days	1.6	1.9	7.1	1.2	1.1	1.0	2.7	0.6	1.0	1.3
Medication: Allopurinol	1.6	2.1	3.5	-1.4	-1.6	-1.5	-1.5	-1.4	-0.2	-1.9
Crohns Disease (2017)	1.5	3.3	5.3	2.3	2.2	1.9	0.4	2.0	2.1	1.0
Maternal smoking around birth	1.5	2.2	4.8	-1.3	-1.5	-1.4	-1.0	-1.4	2.2	-1.2
Medication: Ramipril	1.5	2.0	4.5	1.5	1.3	2.1	0.5	2.1	-0.5	0.7
Alcohol intake versus 10 years previously	1.5	2.2	4.2	1.7	1.7	1.6	0.7	1.2	2.1	1.0
Emphysema/chronic bronchitis	1.5	1.7	2.9	-1.6	-1.5	-1.7	0.3	-1.7	0.4	-1.2
Medication: Seretide 50 evohaler	1.5	1.8	2.8	-1.7	-1.6	-1.6	-1.2	-1.4	0.0	-1.1
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	5.6	0.9	0.8	0.6	2.4	0.3	1.8	1.1
Tense / ‘highly strung’	1.4	2.3	5.4	1.0	1.1	1.0	1.8	0.9	2.3	1.9
Back pain experienced in last month	1.4	2.0	3.2	1.8	1.5	1.6	0.8	1.1	-1.3	1.5
Vascular/heart problems diagnosed by doctor	1.4	3.9	6.6	-2.3	-2.3	-2.6	-1.4	-2.1	1.4	-1.2
Age at First Birth	1.3	1.9	3.0	-1.5	-1.6	-1.3	-1.3	-1.4	-0.3	-1.7
Type 2 Diabetes (T2D) (2018)	1.3	2.4	4.3	2.1	2.0	1.8	0.5	2.0	-0.1	0.7
Medication: Simvastatin	1.3	1.8	3.8	1.3	1.4	1.2	2.0	1.0	-1.1	1.3
Chest pain or discomfort	1.3	1.8	3.3	-1.8	-1.3	-1.8	0.9	-1.8	-0.1	-0.8
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.2	-1.5	-1.4	-1.1	-0.9	-1.4	-1.0	-1.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.3	1.3	1.6	1.6	-0.2	1.8	0.3	0.9
Average weekly red wine intake	1.3	1.9	5.5	-1.0	-1.1	-0.4	-2.3	-0.2	-1.8	-1.5
Illnesses of father: None of the above (group 1)	1.3	1.7	2.7	-1.6	-1.4	-1.4	-0.6	-1.5	0.5	-1.4
Miserableness	1.3	2.2	4.5	1.0	1.2	1.3	2.1	1.0	1.5	1.8
Prostate Cancer	1.2	1.7	2.3	1.4	1.5	1.3	1.4	1.5	0.2	1.5
Systolic Blood Pressure	1.2	5.8	11.4	3.0	2.9	3.0	-0.2	3.4	-0.3	1.8
Impedance of leg (right)	1.2	5.7	13.6	2.3	2.4	1.3	2.7	1.9	1.6	3.7
Falls in the last year	1.2	1.6	3.1	-1.0	-1.7	-0.7	-1.7	-0.9	-0.1	-1.8
Pulse rate, automated reading	1.2	3.9	8.0	1.7	1.9	1.2	2.8	1.5	1.5	2.6
Qualifications: nursing, teaching	1.2	1.8	2.9	-1.6	-1.1	-1.5	-1.1	-1.1	-1.2	-1.7
Medication: Blood pressure	1.2	2.3	6.4	1.4	1.5	1.5	0.6	1.5	-2.5	0.8
Pain type(s) experienced in last month: Hip pain	1.2	1.6	2.4	1.4	1.5	1.6	0.2	1.5	-1.1	1.0
Bipolar Disorder (2011)	1.1	1.1	3.9	-0.2	-0.5	0.2	-2.0	0.3	-0.1	-1.8
Allergy or Eczema	1.1	2.8	4.8	1.8	2.2	1.9	0.9	1.9	0.9	1.7
Fed-up feelings	1.1	1.9	4.9	1.0	1.1	1.0	1.9	0.8	2.2	1.2
High blood pressure	1.1	3.1	5.3	2.1	1.9	2.3	1.3	1.9	-1.5	1.1
Weight	1.1	5.4	7.0	-2.6	-2.5	-2.1	-1.5	-2.3	-2.5	-2.6
Breastfed as a baby	1.1	1.4	2.6	-1.1	-0.9	-1.2	-1.2	-0.8	-1.6	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	4.7	0.4	0.4	0.1	1.9	-0.0	2.2	1.2
Mean time to correctly identify matches	1.1	2.0	3.5	1.9	1.5	1.9	0.6	1.4	1.5	0.8
Family relationship satisfaction	1.1	1.4	1.9	1.2	1.2	1.1	1.0	1.1	1.0	1.4
Knee pain experienced in last month	1.1	1.6	2.9	-1.4	-1.5	-1.1	-1.1	-1.3	-0.1	-1.7
Friendships satisfaction	1.1	1.4	2.7	1.1	1.2	1.0	1.6	1.0	0.9	1.4
Diastolic blood pressure, automated reading	1.1	3.5	5.1	2.1	2.2	1.9	1.1	2.3	-0.8	2.2
Cholesterol lowering medication	1.1	1.6	5.9	-0.9	-0.2	-1.0	2.4	-0.6	-1.6	0.6
Coronary Artery Disease (CAD)	1.0	1.2	2.5	0.9	0.4	1.5	-1.4	1.6	0.5	-0.3
Cardiovascular Disease	1.0	3.4	6.7	2.2	2.0	2.6	1.5	2.1	-0.8	0.8
Systolic blood pressure, automated reading	1.0	2.8	5.5	1.7	1.7	1.7	0.1	2.1	-2.3	1.2
Relative age voice broke	1.0	1.5	4.8	-1.2	-1.1	-2.2	0.3	-1.5	0.8	-0.3
Stomach or abdominal pain in last month	1.0	1.2	5.3	0.4	0.3	0.2	1.5	0.3	2.3	0.6
Had menopause	1.0	1.2	7.7	0.4	0.2	0.6	0.2	0.1	-2.8	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.5	1.1	0.8	0.8	1.4	0.5	2.1	1.0
Age at first live birth	1.0	1.7	3.1	-1.2	-1.3	-1.1	-1.8	-1.0	-1.2	-1.5
Pulse wave peak to peak time	1.0	1.2	2.5	-1.0	-1.2	-0.7	-1.6	-1.1	-0.7	-1.1
Health satisfaction	1.0	1.3	3.8	0.7	0.9	0.8	1.9	0.4	0.7	1.7
Breast cancer (self-reported)	1.0	1.2	2.2	-1.2	-1.5	-1.1	-0.2	-1.1	-1.3	-1.0
Hearing aid user	1.0	1.1	5.6	-0.5	-0.3	-0.6	-0.7	-0.4	-2.4	-0.9
Ever depressed for a whole week	1.0	1.3	3.4	0.8	0.7	0.5	1.8	0.2	1.7	1.1
Average weekly spirits intake	0.9	1.1	2.3	1.3	1.3	1.5	0.0	0.8	1.1	0.6
Impedance of leg (left)	0.9	4.3	11.7	1.9	2.0	0.9	2.5	1.5	1.1	3.4
Worrier / anxious feelings	0.9	1.6	3.1	1.2	1.2	1.7	0.9	1.4	1.2	1.1
Lung cancer (father)	0.9	1.1	2.7	-1.3	-1.6	-0.9	-0.4	-1.4	0.1	-0.4
Exposure to tobacco smoke at home	0.9	1.0	2.0	1.2	1.2	1.2	-0.3	1.4	0.4	0.4
Hypertension (Self-reported)	0.9	2.6	4.7	1.9	1.7	2.2	1.0	1.8	-1.4	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.1	-1.0	-1.2	-0.9	-0.6	-1.2	0.2	-1.4
Medication: Bendroflumethiazide	0.9	1.4	2.8	1.4	1.5	1.7	-0.3	1.6	-0.4	0.3
Medication: Paracetamol	0.9	1.4	3.0	-1.3	-0.9	-1.7	1.1	-1.6	-0.5	0.4
Medication: Atorvastatin	0.9	1.1	4.1	0.5	0.8	0.2	2.0	0.3	-0.7	1.5
Risk taking	0.9	1.3	2.6	-1.2	-1.3	-1.2	0.5	-1.6	1.3	-0.2
Impedance of whole body	0.9	4.6	12.6	2.0	2.2	1.1	2.5	1.7	0.8	3.5
Fasting Glucose	0.8	1.0	2.6	1.1	0.8	1.6	-1.0	1.2	-0.2	-0.1
HDL Cholesterol	0.8	1.4	5.1	0.6	0.9	0.1	1.3	0.6	-2.3	1.1
Supplements: Zinc	0.8	0.9	3.6	-0.3	-0.5	-0.1	-1.9	-0.3	0.4	-1.5
Diabetes (mother)	0.8	1.0	4.2	0.5	0.6	0.4	2.0	0.1	0.2	1.4
Current tobacco smoking	0.8	1.2	2.8	-1.3	-1.4	-1.2	-0.2	-1.7	0.0	-1.0
High blood pressure (mother)	0.8	1.1	2.6	1.3	1.1	1.3	0.2	1.6	0.8	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.8	0.7	0.7	0.6	1.7	0.2	1.3	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	6.2	-0.5	-0.3	-0.8	2.5	-0.9	0.6	0.9
Noisy workplace	0.8	0.9	3.5	0.6	0.4	-0.1	1.5	-0.0	1.9	0.5
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.8	-1.1	-0.9	-1.3	1.1	-1.3	-0.2	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	1.8	-1.3	-1.2	-1.4	-0.7	-1.2	0.3	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	3.6	0.3	0.3	0.6	1.2	0.2	1.9	0.9
Irritable Bowel Disease (IBD)	0.7	1.6	3.1	1.5	1.3	1.3	-0.8	1.5	1.8	-0.2
Hearing difficulty/problems: Yes	0.7	1.0	2.8	-1.1	-0.6	-1.7	1.1	-1.2	0.0	-0.2
Vitamin and mineral supplements	0.7	1.0	2.5	0.8	0.7	0.4	1.6	0.6	-1.0	1.3
Pack years adult smoking proportion	0.7	1.1	2.1	1.0	1.1	1.0	1.4	1.0	0.6	1.1
Allergy	0.7	1.7	3.7	-0.9	-1.6	-0.9	-1.9	-1.0	-0.9	-1.5
Hair/balding pattern: Pattern 3	0.7	1.1	3.5	0.9	0.9	0.9	0.4	0.9	1.9	0.6
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.9	-0.7	-0.8	-0.9	-1.4	-0.8	-0.0	-1.7
Gout (self-reported)	0.7	1.0	3.6	-0.5	-0.7	-0.5	-1.9	-0.4	-0.5	-1.4
Comparative body size at age 10	0.7	1.9	4.7	1.2	1.2	1.6	0.3	1.4	-2.2	1.1
Medication: Ibuprofen	0.7	0.8	2.0	-0.8	-0.4	-1.2	1.4	-1.1	0.5	0.6
Number of full sisters	0.7	0.8	2.9	-0.7	-0.7	-0.9	1.7	-1.0	-0.1	0.1
Smoking status: Current	0.7	1.0	2.4	-1.2	-1.3	-1.0	-0.2	-1.5	0.2	-0.9
Pain experienced in last month	0.7	1.1	2.2	-1.1	-0.9	-1.5	0.8	-1.5	-0.8	-0.3
Heart disease (siblings)	0.7	0.9	4.3	-0.6	-0.4	-0.0	-1.1	-0.2	-2.1	-0.4
Bipolar Disorder or Schizophrenia	0.6	1.5	3.3	1.4	1.1	1.8	-0.4	1.8	0.9	-0.0
Schizophrenia (2018)	0.6	1.3	4.4	0.8	0.7	1.3	-0.3	1.4	2.1	-0.4
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.5	0.9	0.7	1.2	-0.5	0.6	1.1	0.6
Angina	0.6	0.7	1.4	0.7	1.2	0.4	0.6	0.8	-1.0	1.0
Medication for hormone replacement therapy	0.6	0.6	3.7	-0.1	-0.5	0.4	-1.9	0.2	-0.3	-0.3
Qualifications: CSEs or equivalent	0.6	0.8	1.9	-1.0	-0.7	-0.9	0.6	-1.0	1.4	-0.3
Multivitamins +/- minerals	0.6	0.7	1.2	-0.9	-0.9	-0.6	-1.1	-1.1	0.3	-0.8
Waist circumference	0.6	2.2	2.9	-1.6	-1.5	-1.4	0.2	-1.7	-1.7	-1.7
Hair/balding pattern: Pattern 2	0.6	0.8	1.3	0.9	0.9	1.2	-0.8	1.2	-0.5	0.4
Father’s age at death	0.6	0.8	3.7	-0.8	-0.5	-0.6	-0.2	-0.2	-1.9	-0.7
Happiness	0.6	0.8	1.0	0.7	0.8	0.8	1.0	1.0	1.0	0.8
Asthma	0.6	1.2	3.8	0.5	1.1	0.7	1.9	0.9	-0.2	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.9	-0.7	-0.3	-1.1	1.4	-1.0	0.1	0.8
Impedance of arm (left)	0.6	2.8	9.1	1.3	1.5	0.7	2.1	1.0	0.1	3.0
Birth weight of first child	0.6	1.1	2.5	-0.9	-1.3	-1.0	0.0	-1.6	-0.9	-0.7
Medication: Paracetamol	0.6	0.9	2.1	-1.0	-0.6	-1.5	1.1	-1.3	0.3	0.5
Glaucoma (self-reported)	0.6	0.6	1.9	-0.6	-0.7	-1.1	0.2	-0.7	-1.4	0.1
Birth weight	0.6	1.3	2.6	1.1	0.9	1.6	-1.5	1.5	0.1	-0.5
Medication for pain relief, constipation, heartburn	0.6	1.0	3.7	-0.0	-0.6	0.3	-1.9	0.4	0.2	-1.5
Angina (self-reported)	0.6	0.8	1.6	0.8	1.2	0.5	0.6	0.8	-0.9	1.2
Age at last live birth	0.6	0.8	4.3	-0.3	-0.2	-0.5	-0.8	-0.3	-2.1	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.1	-0.5	-0.9	0.2	-1.0	-0.3	1.4	-1.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	3.7	-0.5	-0.7	-0.3	-1.9	-0.2	-0.2	-0.7
Eye problems/disorders: Glaucoma	0.6	0.7	1.7	-1.0	-0.9	-1.3	0.2	-1.0	-0.7	-0.3
Ever smoked	0.6	1.0	2.6	-0.8	-0.9	-0.9	-0.1	-0.8	1.3	-1.6
Myopia	0.6	0.8	1.8	-0.9	-1.1	-0.9	-0.3	-0.9	1.4	-0.4
Pack years of smoking	0.6	0.9	1.3	0.9	1.1	1.0	1.2	0.9	0.5	0.8
Bipolar Disorder (2018)	0.5	0.8	1.5	1.2	0.8	1.2	-0.3	1.2	-0.6	0.5
Intelligence (Savage-Jansen 2018)	0.5	1.5	4.8	-0.7	-1.1	-0.2	-2.2	-0.3	0.3	-1.9
Major Depression (MDD)	0.5	0.6	2.2	-0.1	-0.0	0.4	-1.0	0.1	1.5	-0.9
Reaction Time	0.5	0.9	4.0	0.9	0.4	1.0	0.1	0.7	2.0	0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.4	-0.9	-1.5	-0.7	-1.5	-0.9	0.1	-1.5
LDL Cholesterol	0.5	0.8	2.6	0.4	0.6	-0.4	1.6	0.0	0.2	1.4
Lupus	0.5	0.8	1.8	0.4	0.7	0.2	1.2	0.4	-1.4	1.1
Hypothyroidism (self reported)	0.5	1.2	2.7	1.6	1.3	1.6	-0.0	1.3	0.2	-0.5
Number of treatments/medications taken	0.5	0.8	4.0	0.4	0.6	0.1	2.0	-0.3	-0.7	0.8
Diabetes (father)	0.5	0.7	2.3	0.8	0.7	0.6	0.1	0.8	-1.5	0.7
Medication: Atenolol	0.5	0.6	3.7	0.1	0.3	-0.1	-0.1	-0.3	-1.9	-0.3
Past tobacco smoking	0.5	1.0	3.3	0.4	0.5	0.4	0.5	0.3	-1.8	1.6
Time employed in main current job	0.5	0.6	1.3	-0.8	-0.6	-1.1	-0.3	-0.9	-0.7	-0.4
Number of live births	0.5	0.7	1.3	1.2	1.1	0.9	-0.2	0.8	-0.9	0.2
Pulse rate	0.5	0.9	1.7	1.0	0.9	0.4	1.3	0.8	0.6	1.2
Qualifications: A levels/AS levels or equivalent	0.5	1.2	1.9	-1.2	-1.3	-1.4	-0.4	-1.1	-0.6	-1.3
Pulse wave Arterial Stiffness index	0.5	0.6	1.6	0.6	0.8	0.3	1.3	0.7	0.6	0.7
Pulse wave reflection index	0.5	0.6	2.0	0.2	0.3	0.2	1.4	0.1	1.4	0.4
High blood pressure (siblings)	0.5	0.7	1.3	0.8	0.9	1.2	-0.4	1.1	0.4	0.6
Body fat percentage	0.5	2.1	3.8	1.0	1.3	1.0	1.9	0.9	-1.8	1.7
Exposure to tobacco smoke outside home	0.5	0.6	1.2	-1.0	-1.1	-0.7	-0.4	-1.0	0.4	-0.4
Number of full brothers	0.5	0.6	2.3	0.7	0.5	0.6	-1.5	0.6	0.7	-0.3
Shortness of breath walking on level ground	0.5	0.5	2.7	-0.1	-0.1	-0.2	0.9	-0.2	1.6	0.4
Qualifications: College or University degree	0.5	1.5	3.2	-1.6	-1.3	-1.8	-0.4	-1.2	0.0	-1.1
Supplements: Vitamin C	0.5	0.6	1.5	-0.4	-0.6	-0.1	-1.2	0.0	1.0	-1.2
Illnesses of father: Heart disease	0.5	0.7	2.8	0.2	0.1	0.3	-1.2	0.5	-1.7	-0.6
Smoking status: Previous	0.5	0.7	3.1	0.2	0.1	0.2	-0.5	0.4	1.8	-1.1
Asthma (self-reported)	0.5	1.1	2.1	0.7	1.1	1.0	1.4	1.2	-0.1	1.1
Guilty feelings	0.5	0.7	1.5	-0.8	-0.9	-0.8	1.1	-1.2	0.5	-0.1
Ever taken oral contraceptive pill	0.5	0.5	2.2	-0.1	-0.2	-0.3	-1.1	-0.0	1.5	-0.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.9	0.9	1.0	0.7	0.1	0.7	-0.8	0.9
Depression (Nagel 2018)	0.4	0.6	2.0	0.1	-0.0	0.2	1.4	-0.1	1.4	0.7
Alzheimer’s Disease (in mother)	0.4	0.4	0.7	0.3	0.5	0.8	-0.7	0.7	0.8	0.6
Smoking Status	0.4	1.1	2.9	-0.9	-1.0	-0.6	-1.1	-1.0	0.3	-1.7
Trunk fat percentage	0.4	1.8	4.3	0.8	1.0	0.7	1.8	0.7	-2.1	1.5
Chronic bronchitis/emphysema (father)	0.4	0.5	2.8	-0.1	-0.1	-0.4	-0.0	-0.6	1.7	0.4
Alcohol usually taken with meals	0.4	0.6	1.9	-0.4	-0.0	-0.8	1.0	-0.1	-1.4	0.8
Hearing difficulty/problems with background noise	0.4	0.6	1.3	-0.8	-0.6	-1.1	1.1	-1.0	-0.4	-0.3
Qualifications: None of the above	0.4	0.9	2.2	0.9	0.9	0.5	1.5	0.5	-0.1	1.4
Financial difficulties in last 2 years	0.4	0.5	0.9	-0.7	-0.9	-0.9	-0.4	-0.9	-0.2	-0.6
Impedance of arm (right)	0.4	2.1	5.6	1.2	1.4	0.5	1.8	1.1	0.7	2.4
Hip circumference	0.4	1.7	5.5	-1.4	-1.0	-1.2	0.3	-1.1	-2.3	-0.7
Medication: Lansoprazole	0.4	0.5	0.9	-0.6	-0.7	-0.7	-0.2	-0.8	-1.0	-0.6
Illnesses of mother	0.4	0.4	0.9	-0.5	-0.5	-0.6	-0.8	-0.9	-0.7	-0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	1.7	1.3	0.9	1.2	-0.5	1.0	0.9	-0.4
Leg fat percentage (right)	0.4	1.5	3.8	0.9	1.1	0.7	1.9	0.8	-1.2	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.2	0.3	-0.0	0.5	-1.5	0.5	-0.4	-0.8
Migraine (self-reported)	0.4	0.5	1.4	-0.4	-0.1	-1.1	1.2	-0.7	0.1	0.1
Medication: Omeprazole	0.4	0.5	0.9	0.7	0.7	0.9	-0.5	0.7	0.9	-0.3
Overall health rating	0.4	0.8	1.3	-1.1	-1.0	-0.9	0.5	-1.1	0.6	-0.7
Long-standing illness, disability or infirmity	0.4	0.6	1.2	-0.5	-0.5	-0.8	1.1	-0.8	0.9	-0.2
Osteoporosis (self-reported)	0.4	0.4	1.5	-0.4	-0.8	-0.5	-0.7	-0.3	-0.0	-1.2
Number of self-reported non-cancer illnesses	0.4	0.8	1.4	1.2	1.0	1.2	0.8	0.8	-0.1	0.6
Commuting to job workplace: Public transport	0.4	0.5	2.8	0.3	0.3	-0.1	0.7	0.3	1.7	0.3
Average weekly beer plus cider intake	0.4	0.6	3.2	0.3	0.1	0.1	0.7	-0.3	1.8	0.1
Unable to work because of sickness or disability	0.4	0.5	1.1	-0.7	-1.0	-0.3	-0.6	-0.6	-0.1	-0.8
Supplements: Calcium	0.4	0.5	1.8	0.1	-0.4	0.2	-1.3	-0.2	0.8	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	-0.6	-0.4	-0.2	-1.0	0.2	-1.0	-0.9
Breast Cancer	0.3	0.6	1.8	0.5	0.6	0.4	1.3	0.3	-0.1	1.2
Blood Eosinophil Count	0.3	2.4	4.1	-2.0	-1.6	-2.0	-0.0	-2.0	-1.3	-0.7
Medication: Metformin	0.3	0.4	0.7	-0.6	-0.5	-0.8	-0.2	-0.8	-0.3	-0.8
Severe depression (siblings)	0.3	0.4	1.8	0.3	-0.1	-0.0	0.1	-0.1	1.3	0.8
Average weekly fortified wine intake	0.3	0.3	1.0	-0.5	-0.4	-0.9	0.1	-1.0	-0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.4	0.8	0.8	0.7	0.4	0.7	0.6	1.6
Trunk fat mass	0.3	1.3	5.8	-1.0	-0.8	-0.8	0.3	-0.9	-2.4	-0.6
Had other major operations	0.3	0.4	2.1	0.1	0.1	0.1	-0.6	0.2	-1.5	-0.1
Mouth/teeth dental problems	0.3	0.5	1.2	0.6	0.6	0.6	0.2	0.9	-1.1	0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.0	0.5	0.7	0.5	0.3	0.5	0.1	1.0
Arm fat percentage (right)	0.3	1.1	2.0	0.8	1.1	0.9	1.4	0.9	-1.1	1.1
Prospective memory result	0.3	0.4	0.8	-0.4	-0.5	-0.4	0.9	-0.7	0.6	-0.6
Hair/balding pattern: Pattern 4	0.3	0.8	2.9	-0.6	-1.0	-0.6	0.3	-1.0	-1.7	-0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.3	-0.3	-0.2	-0.5	1.1	-0.7	0.9	0.0
Number of children fathered	0.3	0.4	0.8	-0.8	-0.5	-0.9	0.2	-0.7	-0.6	-0.5
Leg fat mass (right)	0.3	1.1	4.7	-0.8	-0.8	-0.6	-0.1	-0.7	-2.2	-0.8
Had major operations	0.3	0.3	1.4	-0.1	-0.0	-0.1	0.8	-0.2	1.2	0.1
Arm fat percentage (left)	0.3	1.3	2.6	0.7	0.9	0.8	1.6	0.6	-1.5	1.3
Medication for cholesterol	0.3	0.4	1.5	-0.1	-0.4	-0.5	-0.4	-0.6	1.2	-0.5
Medication: Gliclazide	0.3	0.3	1.3	0.2	0.4	-0.1	0.8	0.1	-1.1	0.2
Wears glasses or contact lenses	0.3	0.3	0.8	0.3	0.0	-0.0	0.7	-0.2	-0.9	0.9
Leg fat percentage (left)	0.3	1.1	2.9	0.6	0.8	0.4	1.7	0.4	-1.5	1.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.7	0.6	0.6	0.8	-0.2	0.5	0.6	-0.5
Leg fat mass (left)	0.3	1.3	5.3	-1.0	-0.9	-0.7	-0.2	-0.8	-2.3	-0.9
Body Mass Index (BMI) (2010)	0.2	0.2	0.7	0.2	0.5	0.4	-0.5	0.3	0.9	-0.1
Mean Putamen Volume	0.2	0.2	0.5	-0.5	-0.5	-0.4	-0.3	-0.7	0.2	-0.2
Rheumatoid Arthritis	0.2	0.3	1.6	0.1	0.1	-0.2	0.4	0.1	-1.3	0.2
Schizophrenia (2014)	0.2	0.5	1.6	0.2	0.2	0.5	-0.5	0.8	1.3	-0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.2	0.3	0.4	0.2	-1.1	0.4	-0.4	-0.0
Blood Platelet Count	0.2	2.5	5.2	1.7	1.5	1.9	-0.3	2.3	1.9	-0.0
Blood Red Count	0.2	1.8	4.2	-1.6	-1.4	-2.0	-0.5	-1.7	0.1	-0.9
BMI	0.2	1.3	5.7	0.6	0.9	1.1	0.3	1.0	-2.4	0.1
Waist Hip Ratio (WHR)	0.2	0.7	1.6	-0.5	-0.6	-0.7	0.6	-1.3	0.1	-1.3
Lung FEV1/FVC ratio	0.2	1.1	2.3	-1.0	-0.8	-1.2	-1.1	-1.0	-0.0	-1.5
Chronotype (morning person)	0.2	0.5	0.9	-0.6	-0.5	-0.9	0.9	-0.9	-0.5	0.6
Hand grip strength (left)	0.2	0.6	1.2	-1.1	-0.8	-0.9	-0.1	-1.1	-0.2	-0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	0.5	0.0	0.9	0.1	0.5	0.4	-0.1
Diabetes (self-reported)	0.2	0.3	1.7	0.0	0.1	-0.1	1.3	-0.2	-0.3	-0.1
Illnesses of siblings	0.2	0.2	0.4	-0.3	-0.6	-0.6	0.6	-0.6	0.3	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.9	-0.2	-0.1	-0.4	0.9	-0.7	0.2	0.2
Mouth/teeth dental problems: Dentures	0.2	0.4	0.7	0.8	0.7	0.8	0.3	0.5	0.7	0.3
Arm fat mass (right)	0.2	0.6	2.8	-0.7	-0.6	-0.3	0.1	-0.6	-1.7	-0.7
Blood clot in the leg (DVT)	0.2	0.2	0.6	-0.5	-0.4	-0.3	-0.5	0.1	-0.8	-0.5
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.0	-0.1	-0.3	-0.1	1.0	-0.4	0.5	0.6
Worry too long after embarrassment	0.2	0.4	1.6	-0.6	-0.5	-0.4	1.3	-0.4	-0.1	-0.3
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	-0.6	-0.4	-0.5	-0.4	-0.5	-0.8	-0.4
Eye problems/disorders: None of the above	0.2	0.2	0.7	0.3	0.4	0.5	0.1	0.6	0.3	0.8
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	0.4	0.3	0.5	-0.7	0.1	0.7	-0.4
Heart disease (mother)	0.2	0.3	0.6	-0.2	-0.4	-0.1	-0.7	0.2	-0.8	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.5	-0.0	0.3	-0.2	-0.0	0.2	1.2	-0.3
Whole body fat mass	0.2	0.8	4.6	-0.6	-0.4	-0.3	0.4	-0.5	-2.1	-0.3
Leg pain on walking	0.2	0.3	0.9	-0.3	-0.4	-0.2	0.7	-0.5	0.9	0.2
Illnesses of siblings: Diabetes	0.2	0.2	0.7	-0.0	0.2	0.2	-0.8	0.2	0.8	-0.2
Diabetes diagnosed by doctor	0.2	0.4	1.3	0.6	0.5	0.4	1.1	0.3	-0.7	0.1
Commuting to job workplace: Walk	0.2	0.2	1.0	0.0	-0.0	-0.3	1.0	0.1	-0.4	0.4
Eye problems/disorders: Cataract	0.2	0.2	0.6	-0.3	-0.5	-0.4	-0.1	-0.6	0.3	-0.7
Mineral and other dietary supplements	0.2	0.2	0.3	-0.4	-0.4	-0.6	-0.4	-0.5	-0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.7	-0.8	-0.8	-0.7	0.3	-0.5	-0.5	0.4
Arm fat mass (left)	0.2	0.7	4.1	-0.5	-0.4	-0.1	0.4	-0.4	-2.0	-0.3
Basal cell carcinoma (self-reported)	0.2	0.2	1.5	-0.2	-0.1	-0.1	0.2	-0.0	1.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.2	1.2	-0.1	-0.0	-0.0	0.6	0.2	-1.1	0.2
Alcohol drinker status: Previous	0.2	0.2	0.7	-0.3	-0.5	-0.1	0.3	-0.8	-0.3	-0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.5	-0.3	0.1	-0.0	-0.2	0.2	0.1	-0.7
Ulcerative Colitis (UC)	0.1	0.2	0.7	0.2	0.2	0.1	-0.5	0.3	0.8	-0.6
Crohns Disease (2012)	0.1	0.1	0.4	0.6	0.4	0.4	-0.2	0.1	-0.2	-0.0
HbA1C	0.1	0.1	0.5	-0.2	-0.2	0.1	-0.7	0.3	0.5	-0.0
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.4	-0.4	-0.5	-0.0	-0.4	-0.1	-0.1
Triglycerides	0.1	0.1	0.4	0.1	-0.0	0.0	-0.4	0.2	-0.4	-0.6
Ulcerative Colitis	0.1	0.2	0.5	0.2	0.2	0.3	-0.7	0.5	0.0	-0.4
Blood White Count	0.1	0.8	2.0	0.6	0.8	1.2	-0.9	1.4	0.1	-0.0
Heel T-Score	0.1	0.5	2.1	0.2	0.3	0.3	0.7	0.3	-0.9	1.5
Lung FVC	0.1	0.5	2.3	-0.3	-0.0	-0.2	0.4	-0.1	-1.5	0.8
Tanning	0.1	1.4	6.2	0.3	-0.2	0.9	-1.5	0.6	2.5	-0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	-0.3	-0.2	-0.3	0.1	0.0	0.5	-0.5
Medication: Co-codamol	0.1	0.1	0.3	-0.1	-0.1	0.2	0.4	-0.1	-0.5	-0.4
Taking other prescription medications	0.1	0.2	1.0	0.5	0.3	0.3	1.0	0.1	0.3	0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.7	-0.2	-0.2	-0.1	-0.1	0.2	0.8	-0.5
Supplements: Glucosamine	0.1	0.2	1.0	-0.0	-0.1	0.4	-0.0	0.0	1.0	-0.4
Medication: Levothyroxine sodium	0.1	0.2	0.8	-0.0	-0.3	-0.2	-0.5	-0.2	-0.7	-0.9
Body mass index (BMI)	0.1	0.4	1.8	0.3	0.4	0.6	0.6	0.2	-1.3	0.0
Number of incorrect matches in round	0.1	0.2	0.8	-0.4	-0.4	-0.3	-0.9	-0.3	-0.1	-0.5
Heart attack	0.1	0.2	0.6	-0.4	-0.4	-0.4	0.5	-0.1	-0.8	-0.1
Headache pain in last month	0.1	0.2	1.1	0.1	0.0	0.0	0.5	0.4	0.5	1.0
Medication: Amlodipine	0.1	0.2	0.4	0.3	0.6	0.3	0.2	0.4	0.6	0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	0.1	0.1	0.1	0.6	0.2	-0.3	0.4
Alcohol intake frequency.	0.1	0.3	1.4	-0.0	0.1	0.0	0.7	-0.4	1.2	0.2
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.3	-0.4	-0.3	-0.4	0.1	-0.2	-0.3
Financial situation satisfaction	0.1	0.1	0.3	0.3	0.1	0.5	-0.2	0.3	0.6	-0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.7	0.1	0.3	0.2	0.8	0.3	-0.1	0.6
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.4	-0.4	-0.5	-0.2	0.2	-0.1	-0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.5	0.1	0.0	0.2	-0.7	0.1	-0.5	0.1
Age started oral contraceptive pill	0.1	0.1	0.2	0.1	0.4	-0.1	0.2	0.0	0.3	0.3
Commuting to job workplace: Cycle	0.1	0.1	0.5	-0.2	-0.2	-0.1	-0.5	0.2	0.7	-0.1
Ovarian Cancer	0.0	0.1	0.2	-0.2	-0.0	-0.0	-0.3	-0.1	-0.4	-0.3
Respiratory disease	0.0	0.1	0.2	-0.3	0.0	0.1	-0.3	0.1	0.5	-0.3
Hair Pigment	0.0	0.5	2.4	0.2	0.1	-0.1	0.9	-0.6	-1.5	0.4
Hand grip strength (right)	0.0	0.1	0.3	-0.4	-0.1	-0.3	-0.5	-0.1	0.5	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	0.2	0.3	0.5	-0.3	0.4	0.1	0.4
Fluid intelligence score	0.0	0.1	0.4	0.1	-0.0	0.1	-0.6	0.4	0.2	-0.2
Number of operations (self-reported)	0.0	0.1	0.2	0.0	-0.1	-0.1	-0.2	-0.3	-0.5	-0.1

Hub : Genes

FAM210B

Models

Trait associations