Best TWAS P=3.6e-43 · Best GWAS P=3.4e-42 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ARFGEF2 | 0.09 | 0.05 | lasso | 8 | 0.10 | 9.2e-13 | 13.3 | -13.0 | 8.1e-39 | -0.82 | 0.01 | 0.99 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | CSE1L | 0.08 | 0.07 | bslmm | 503 | 0.05 | 1.7e-06 | -4.7 | -8.6 | 1.0e-17 | -0.58 | 0.92 | 0.08 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | STAU1 | 0.09 | 0.00 | bslmm | 500 | 0.01 | 8.7e-03 | -3.6 | -5.3 | 1.0e-07 | -0.30 | 0.26 | 0.06 | TRUE |
4 | GTEx | Artery Tibial | CSE1L | 0.12 | 0.03 | lasso | 6 | 0.04 | 3.8e-04 | -4.5 | -8.2 | 1.8e-16 | -0.68 | 0.32 | 0.66 | FALSE |
5 | GTEx | Brain Nucleus accumbens basal ganglia | BCAS4 | 0.33 | 0.01 | lasso | 7 | 0.00 | 4.6e-01 | 5.8 | -6.4 | 1.2e-10 | -0.01 | 0.06 | 0.12 | FALSE |
6 | GTEx | Brain Nucleus accumbens basal ganglia | SLC9A8 | 0.42 | 0.09 | lasso | 7 | 0.08 | 3.8e-03 | -5.9 | 5.3 | 1.2e-07 | -0.06 | 0.07 | 0.11 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | STAU1 | 0.08 | 0.03 | lasso | 6 | 0.02 | 2.3e-02 | 10.9 | 12.1 | 9.3e-34 | 0.85 | 0.03 | 0.91 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | ZFAS1 | 0.06 | 0.05 | enet | 5 | 0.03 | 2.6e-03 | -7.2 | 7.2 | 6.6e-13 | 0.29 | 0.40 | 0.28 | FALSE |
9 | GTEx | Colon Sigmoid | ARFGEF2 | 0.15 | 0.12 | lasso | 1 | 0.07 | 2.3e-03 | 9.4 | -9.4 | 7.5e-21 | -0.60 | 0.06 | 0.60 | FALSE |
10 | GTEx | Colon Sigmoid | CSE1L | 0.18 | 0.12 | lasso | 11 | 0.09 | 4.4e-04 | 11.7 | -11.9 | 1.3e-32 | -0.80 | 0.10 | 0.86 | FALSE |
11 | GTEx | Colon Transverse | ARFGEF2 | 0.11 | 0.07 | enet | 12 | 0.09 | 2.9e-05 | -4.5 | -9.7 | 2.6e-22 | -0.78 | 0.18 | 0.74 | FALSE |
12 | GTEx | Colon Transverse | CSE1L | 0.17 | 0.01 | enet | 19 | 0.03 | 1.2e-02 | 5.0 | -7.3 | 2.7e-13 | -0.49 | 0.18 | 0.22 | FALSE |
13 | GTEx | Esophagus Gastroesophageal Junction | CSE1L | 0.17 | 0.07 | lasso | 5 | 0.07 | 1.6e-03 | -4.4 | -6.5 | 9.5e-11 | -0.49 | 0.29 | 0.27 | TRUE |
14 | GTEx | Esophagus Mucosa | CSE1L | 0.09 | 0.06 | lasso | 4 | 0.06 | 6.9e-05 | 12.0 | -11.1 | 8.1e-29 | -0.80 | 0.18 | 0.77 | FALSE |
15 | GTEx | Esophagus Mucosa | ZFAS1 | 0.15 | 0.01 | enet | 16 | 0.01 | 8.9e-02 | 13.3 | 8.9 | 5.4e-19 | 0.69 | 0.03 | 0.90 | FALSE |
16 | GTEx | Esophagus Muscularis | CSE1L | 0.16 | 0.14 | enet | 22 | 0.12 | 5.1e-08 | -4.5 | -5.4 | 6.5e-08 | -0.44 | 0.97 | 0.03 | FALSE |
17 | GTEx | Lung | CSE1L | 0.10 | 0.09 | lasso | 5 | 0.08 | 6.6e-07 | 10.9 | -10.8 | 2.3e-27 | -0.73 | 0.65 | 0.34 | FALSE |
18 | GTEx | Muscle Skeletal | PREX1 | 0.14 | 0.09 | enet | 23 | 0.13 | 2.5e-12 | 10.3 | 8.2 | 1.6e-16 | 0.51 | 0.85 | 0.15 | FALSE |
19 | GTEx | Nerve Tibial | CSE1L | 0.12 | 0.01 | lasso | 10 | 0.03 | 5.7e-03 | -4.6 | -5.4 | 5.2e-08 | -0.48 | 0.20 | 0.21 | FALSE |
20 | GTEx | Skin Not Sun Exposed Suprapubic | ZFAS1 | 0.16 | 0.04 | enet | 19 | 0.07 | 1.0e-04 | 8.6 | 8.5 | 1.8e-17 | 0.69 | 0.05 | 0.89 | FALSE |
21 | GTEx | Skin Sun Exposed Lower leg | CSE1L | 0.08 | 0.03 | lasso | 2 | 0.03 | 9.5e-04 | 12.2 | -11.6 | 3.0e-31 | -0.81 | 0.47 | 0.16 | FALSE |
22 | GTEx | Skin Sun Exposed Lower leg | ZFAS1 | 0.07 | 0.03 | enet | 14 | 0.05 | 5.8e-05 | 13.3 | 10.1 | 6.6e-24 | 0.77 | 0.03 | 0.96 | FALSE |
23 | GTEx | Testis | ARFGEF2 | 0.20 | 0.20 | lasso | 7 | 0.24 | 5.4e-11 | 10.9 | -12.8 | 2.3e-37 | -0.91 | 0.02 | 0.98 | FALSE |
24 | GTEx | Whole Blood | ZFAS1 | 0.07 | 0.06 | lasso | 4 | 0.05 | 1.3e-05 | -7.2 | -7.3 | 2.5e-13 | -0.20 | 1.00 | 0.00 | TRUE |
25 | METSIM | Adipose | ARFGEF2 | 0.04 | 0.03 | lasso | 12 | 0.02 | 9.8e-05 | 13.6 | -13.8 | 3.6e-43 | -0.98 | 0.02 | 0.98 | TRUE |
26 | METSIM | Adipose | CSE1L | 0.05 | 0.05 | lasso | 4 | 0.04 | 5.3e-07 | -4.5 | -6.7 | 2.9e-11 | -0.58 | 0.91 | 0.09 | FALSE |
27 | METSIM | Adipose | RP11-290F20.3 | 0.04 | 0.03 | enet | 13 | 0.02 | 1.1e-04 | 4.4 | 5.2 | 2.0e-07 | 0.05 | 0.66 | 0.18 | TRUE |
28 | NTR | Blood | NCRNA00275 | 0.07 | 0.06 | lasso | 4 | 0.08 | 9.7e-25 | -5.9 | -10.5 | 5.6e-26 | -0.53 | 1.00 | 0.00 | TRUE |
29 | NTR | Blood | SNORD12B | 0.03 | 0.05 | lasso | 8 | 0.05 | 1.9e-14 | 13.3 | -13.7 | 1.2e-42 | -0.96 | 0.02 | 0.98 | FALSE |
30 | ROSMAP | Brain Pre-frontal Cortex | CSE1L | 0.04 | 0.02 | enet | 16 | 0.02 | 2.8e-03 | 9.4 | -10.5 | 7.5e-26 | -0.72 | 0.10 | 0.89 | FALSE |
31 | YFS | Blood | CSE1L | 0.06 | 0.05 | enet | 21 | 0.06 | 2.0e-19 | -4.6 | -9.0 | 2.2e-19 | -0.60 | 1.00 | 0.00 | FALSE |
32 | YFS | Blood | PTPN1 | 0.37 | 0.30 | enet | 21 | 0.30 | 1.1e-101 | 5.8 | -6.8 | 1.2e-11 | 0.00 | 0.99 | 0.01 | TRUE |
33 | YFS | Blood | ZNFX1 | 0.06 | 0.05 | lasso | 3 | 0.05 | 1.4e-16 | 5.4 | -7.1 | 1.0e-12 | -0.55 | 1.00 | 0.00 | FALSE |
34 | The Cancer Genome Atlas | Breast Invasive Carcinoma | STAU1 | 0.01 | 0.01 | blup | 54 | 0.01 | 6.1e-03 | -7.2 | -8.5 | 2.4e-17 | -0.46 | 0.03 | 0.13 | FALSE |
35 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNAI1 | 0.09 | 0.10 | lasso | 5 | 0.06 | 3.1e-04 | -7.6 | 7.6 | 2.2e-14 | -0.03 | 0.20 | 0.56 | TRUE |
36 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CSE1L | 0.03 | 0.05 | lasso | 1 | 0.03 | 9.3e-05 | 10.9 | -10.9 | 1.3e-27 | -0.75 | 0.28 | 0.64 | FALSE |
37 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CSE1L | 0.05 | 0.07 | blup | 50 | 0.07 | 3.2e-08 | 11.6 | -11.4 | 7.0e-30 | -0.80 | 0.42 | 0.58 | FALSE |
38 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARFGEF2 | 0.05 | 0.04 | lasso | 5 | 0.05 | 3.2e-06 | 13.3 | -13.6 | 4.4e-42 | -0.94 | 0.00 | 1.00 | FALSE |
39 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SLC9A8 | 0.07 | 0.02 | blup | 82 | 0.02 | 8.6e-04 | -6.8 | 5.8 | 5.7e-09 | -0.01 | 0.01 | 0.97 | FALSE |
40 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C20orf199 | 0.04 | 0.00 | enet | 8 | 0.02 | 6.4e-03 | 5.4 | 8.6 | 9.2e-18 | 0.62 | 0.01 | 0.50 | FALSE |
41 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C20orf199 | 0.05 | 0.06 | lasso | 4 | 0.06 | 1.0e-04 | 13.4 | 13.4 | 9.3e-41 | 0.92 | 0.00 | 0.96 | FALSE |
42 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CSE1L | 0.13 | 0.03 | blup | 50 | 0.07 | 1.4e-03 | 10.9 | -10.0 | 1.5e-23 | -0.60 | 0.03 | 0.27 | FALSE |
43 | The Cancer Genome Atlas | Thyroid Carcinoma | ARFGEF2 | 0.06 | 0.01 | blup | 79 | 0.03 | 4.2e-04 | -5.9 | -8.1 | 5.8e-16 | -0.42 | 0.75 | 0.05 | FALSE |
44 | The Cancer Genome Atlas | Thyroid Carcinoma | DDX27 | 0.08 | 0.05 | lasso | 3 | 0.05 | 1.9e-05 | 13.3 | 11.6 | 7.1e-31 | 0.85 | 0.02 | 0.96 | FALSE |
45 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC9A8 | 0.21 | 0.12 | blup | 83 | 0.13 | 5.7e-13 | -3.0 | 5.3 | 9.5e-08 | -0.03 | 0.25 | 0.75 | FALSE |