TWAS hub - AURKA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0444	0.0223	0.0024	0.028	0.023	0.026	NA	0.024	0.00033	0.0011	0.0005	NA	0.00095
2	TCGA	Rectum Adenocarcinoma	0.2850	0.1130	0.0038	0.000	0.068	0.050	NA	0.047	0.31000	0.0110	0.0250	NA	0.03000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Mean Putamen Volume	4.3	5.0	6.9	-2.6	-1.7
Comparative height size at age 10	3.9	21.7	39.4	-6.3	-2.0
Chest pain or discomfort	3.9	5.6	7.3	-2.7	-2.0
Ever had bowel cancer screening	3.7	4.4	6.1	2.5	1.6
Ever had hysterectomy (womb removed)	3.4	3.8	5.8	2.4	1.4
Exposure to tobacco smoke at home	3.3	3.7	7.3	2.7	0.4
Loud music exposure frequency	3.3	3.6	3.7	-1.9	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	3.1	6.5	11.6	-3.4	-1.2
Alzheimer’s Disease (including proxy)	3.0	4.3	8.2	0.7	2.9
Tinnitus: Yes, but not now, but have in the past	2.7	2.8	3.9	-2.0	-1.3
Depression (self-reported)	2.7	3.3	5.1	1.2	2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.1	4.4	-1.3	-2.1
Medication: Lisinopril	2.5	3.2	4.7	1.3	2.2
Trunk fat-free mass	2.4	13.7	16.4	-4.0	-3.3
Peak expiratory flow (PEF)	2.4	5.5	6.9	-2.0	-2.6
Number of full sisters	2.4	3.0	3.5	-1.9	-1.6
Qualifications: NVQ or HND or HNC or equivalent	2.4	2.9	4.2	-2.1	-1.2
Trunk predicted mass	2.3	13.1	15.8	-4.0	-3.2
Length of working week for main job	2.3	2.6	3.3	-1.3	-1.8
Whole body fat-free mass	2.3	13.1	15.1	-3.9	-3.3
Whole body water mass	2.3	12.9	15.1	-3.9	-3.3
Basal metabolic rate	2.3	12.5	15.0	-3.9	-3.2
Medication: Co-codamol	2.2	2.5	4.4	-0.8	-2.1
Arm fat-free mass (right)	2.1	10.6	11.3	-3.4	-3.1
Medication: Blood pressure	2.1	3.8	6.2	2.5	1.2
Leg predicted mass (right)	2.1	11.2	13.9	-3.7	-2.9
Arm fat-free mass (left)	2.1	10.4	10.5	-3.2	-3.2
Arm predicted mass (left)	2.1	10.8	11.2	-3.3	-3.2
Leg fat-free mass (right)	2.0	10.9	13.6	-3.7	-2.9
Leg fat-free mass (left)	1.9	10.3	11.6	-3.4	-3.0
Leg predicted mass (left)	1.9	10.2	11.8	-3.4	-2.9
Medication: Cholesterol lowering	1.9	3.0	5.2	2.3	0.8
Arm predicted mass (right)	1.9	9.5	10.3	-3.2	-3.0
Pain experienced in last month	1.9	3.2	3.7	1.7	1.9
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	5.6	-2.4	-0.6
Medication: Gliclazide	1.8	2.0	3.7	0.6	1.9
Severe depression (siblings)	1.7	1.9	3.7	-0.4	1.9
Qualifications: CSEs or equivalent	1.7	2.2	3.1	-1.8	-1.1
Mouth/teeth dental problems	1.7	2.5	2.8	1.5	1.7
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	2.5	-1.4	-1.6
Knee pain experienced in last month	1.7	2.7	3.0	-1.7	-1.5
Osteoporosis (self-reported)	1.7	2.1	3.4	1.8	-0.9
Smoking Status	1.6	3.8	4.0	-1.9	-2.0
Supplements: Glucosamine	1.6	2.1	2.6	-1.6	-1.2
Waist circumference	1.6	5.9	7.8	-2.0	-2.8
Medication: Ventolin 100micrograms inhaler	1.6	2.0	2.8	-1.1	-1.7
Eye problems/disorders: None of the above	1.6	1.8	3.6	0.2	1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	2.4	-1.6	-1.0
Supplements: Fish oil (including cod liver oil)	1.6	2.0	3.8	0.6	1.9
Alzheimer’s Disease (in mother)	1.5	1.8	3.4	0.3	1.9
Hypothyroidism (self reported)	1.5	3.5	5.4	1.3	-2.3
Chronotype (morning person)	1.5	3.4	6.9	0.1	2.6
Illnesses of siblings	1.5	2.1	3.5	0.8	1.9
Standing height	1.5	15.2	27.1	-5.2	-1.8
Wears glasses or contact lenses	1.5	1.7	3.3	0.2	1.8
Pack years of smoking	1.5	2.2	4.0	2.0	0.6
Serious illness, injury or assault to yourself	1.4	1.6	3.1	-1.7	-0.5
Chronic bronchitis/emphysema (father)	1.4	1.6	3.1	1.8	0.4
Weight	1.4	6.9	8.0	-2.8	-2.4
Pulse rate	1.4	2.3	4.2	2.1	0.7
Comparative body size at age 10	1.4	3.8	3.9	1.9	2.0
Wheeze or whistling in the chest in last year	1.4	2.6	4.7	-0.7	-2.2
Loneliness, isolation	1.4	1.9	2.3	1.2	1.5
Pack years adult smoking proportion	1.3	2.0	3.7	1.9	0.6
Sitting height	1.3	9.5	18.3	-4.3	-0.8
Pain all over the body in last month	1.3	1.4	1.8	-1.3	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	2.2	-1.1	1.5
Mother’s age at death	1.3	1.7	2.6	0.9	1.6
Systolic Blood Pressure	1.2	5.8	11.0	3.3	0.8
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	2.6	-1.6	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	4.4	1.0	2.1
Medication: Atenolol	1.2	1.5	2.5	1.6	-0.7
Falls in the last year	1.2	1.6	2.8	-0.6	-1.7
Noisy workplace	1.2	1.5	2.5	1.6	-0.7
Migraine (self-reported)	1.2	1.5	1.9	1.0	1.4
Qualifications: nursing, teaching	1.2	1.9	2.1	-1.4	-1.3
Eye problems/disorders: Cataract	1.2	1.4	2.3	0.7	-1.5
Illnesses of father: None of the above (group 1)	1.2	1.4	2.8	-1.7	-0.3
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.7	-0.4	1.6
Height	1.1	22.0	35.8	-6.0	-2.9
Cardiovascular Disease	1.1	3.7	5.8	2.4	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	2.7	0.4	1.7
Forced vital capacity (FVC)	1.1	4.2	6.3	-2.5	-1.4
Medication: Simvastatin	1.1	1.6	3.1	1.8	0.3
Commuting to job workplace: Cycle	1.1	1.3	1.9	-1.4	-0.9
Supplements: Zinc	1.0	1.1	2.1	1.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.2	-1.5	-1.0
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	4.0	-2.0	-1.6
Prospective memory result	1.0	1.3	2.5	1.6	-0.1
Lung cancer (father)	1.0	1.2	2.4	0.0	1.6
Commuting to job workplace: Walk	1.0	1.1	1.8	-1.3	-0.6
Medication: Aspirin	1.0	1.3	2.2	1.5	0.7
Commuting to job workplace: Public transport	1.0	1.2	1.7	-1.3	-0.9
Medication: Paracetamol	1.0	1.5	2.7	-1.7	-0.5
Supplements: Calcium	1.0	1.1	2.2	1.5	-0.2
Alcohol drinker status: Previous	1.0	1.1	2.2	-1.5	-0.2
Alzheimer’s Disease (in father)	0.9	1.0	1.4	0.8	1.2
Irritable Bowel Disease (IBD)	0.9	2.2	4.4	2.1	-0.0
Triglycerides	0.9	1.5	3.0	1.7	0.0
Lung FEV1/FVC ratio	0.9	4.6	8.5	0.9	-2.9
Frequency of depressed mood in last 2 weeks	0.9	1.3	1.8	0.9	1.3
Time employed in main current job	0.9	1.0	1.9	1.4	-0.5
Father’s age at death	0.9	1.2	2.3	-1.5	-0.3
Impedance of arm (left)	0.9	4.3	8.4	0.4	2.9
Breastfed as a baby	0.9	1.1	2.2	-1.5	0.1
Forced vital capacity (FVC), Best measure	0.9	3.3	5.9	-2.4	-0.9
Heart disease (mother)	0.9	1.1	1.2	-1.1	-1.0
Family relationship satisfaction	0.9	1.1	1.1	1.1	1.0
Medication: Aspirin	0.9	1.2	1.4	1.2	1.0
Heart disease (siblings)	0.9	1.1	1.7	-0.7	-1.3
Impedance of whole body	0.9	4.4	7.4	1.2	2.7
Bipolar Disorder or Schizophrenia	0.8	1.9	3.7	1.9	-0.1
Waist Hip Ratio (WHR)	0.8	3.8	7.3	-0.6	-2.7
Relative age of first facial hair	0.8	1.7	2.9	1.7	0.7
Systolic blood pressure, automated reading	0.8	2.4	4.7	2.2	0.4
Impedance of leg (right)	0.8	3.7	5.2	1.5	2.3
Had other major operations	0.8	1.0	1.2	-1.1	-0.9
Number of live births	0.8	1.1	1.5	1.2	-0.9
Tense / ‘highly strung’	0.8	1.3	2.3	0.6	1.5
Pulse wave reflection index	0.8	1.0	1.0	-1.0	-1.0
Leg fat mass (right)	0.8	2.9	3.7	-1.5	-1.9
Leg pain on walking	0.8	1.1	1.7	-0.7	-1.3
Eye problems/disorders: Glaucoma	0.8	0.9	1.4	-1.2	-0.6
Ever smoked	0.8	1.4	1.9	-0.9	-1.4
Vascular/heart problems diagnosed by doctor	0.8	2.2	3.9	-2.0	0.6
Basal cell carcinoma (self-reported)	0.8	0.9	1.3	-0.7	-1.2
Schizophrenia (2018)	0.7	1.5	2.9	1.7	-0.3
Ulcerative Colitis (UC)	0.7	1.4	2.4	1.5	0.6
Reaction Time	0.7	1.3	2.1	0.7	-1.4
Age at First Birth	0.7	1.1	1.5	-1.2	-0.8
Diabetes (father)	0.7	0.9	1.0	0.9	1.0
Impedance of leg (left)	0.7	3.5	5.4	1.3	2.3
Past tobacco smoking	0.7	1.2	2.3	0.4	1.5
Hearing difficulty/problems with background noise	0.7	1.2	2.1	-1.4	-0.5
Hair/balding pattern: Pattern 2	0.7	0.9	1.4	0.7	1.2
Hip circumference	0.7	3.1	4.1	-2.0	-1.4
Alcohol intake versus 10 years previously	0.7	1.1	2.1	1.5	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	3.4	-1.9	-1.1
Arm fat mass (right)	0.7	2.8	2.8	-1.7	-1.7
Medication: Paracetamol	0.7	1.2	1.5	-1.2	-0.9
Glaucoma (self-reported)	0.7	0.8	1.6	-1.3	-0.2
Mean time to correctly identify matches	0.7	1.4	1.5	1.2	-1.1
Suffer from ‘nerves’	0.7	1.1	2.2	0.2	1.5
Average weekly red wine intake	0.7	1.0	1.8	-1.3	-0.4
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.6	0.5	-1.3
Heart attack/myocardial infarction (self-reported)	0.7	0.8	1.5	1.2	0.5
Leg fat mass (left)	0.7	2.8	3.4	-1.5	-1.8
Lupus	0.6	0.9	1.6	1.3	0.4
Schizophrenia (2014)	0.6	1.3	2.4	1.6	-0.4
Respiratory disease	0.6	1.3	1.6	-1.3	-1.0
Current tobacco smoking	0.6	0.9	1.0	-1.0	-0.9
Relative age voice broke	0.6	0.9	1.0	0.9	-1.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.6	-0.1	1.3
Impedance of arm (right)	0.6	3.0	6.0	0.2	2.4
Medication: Lansoprazole	0.6	0.7	0.7	-0.8	-0.9
Birth weight	0.6	1.3	2.3	1.5	0.5
Commuting to job workplace: Car/motor vehicle	0.6	0.6	0.7	0.8	0.8
Hypertension (Self-reported)	0.6	1.7	2.9	1.7	-0.7
Smoking status: Current	0.6	0.9	1.0	-1.0	-0.9
Arm fat mass (left)	0.6	2.5	2.5	-1.6	-1.6
Average weekly champagne plus white wine intake	0.6	0.8	1.4	-0.5	-1.2
Diastolic blood pressure, automated reading	0.6	1.7	3.4	1.8	-0.1
Crohns Disease (2017)	0.5	1.1	2.1	1.4	-0.4
Breast Cancer	0.5	1.1	1.5	0.9	1.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.6	1.3	0.6
Fed-up feelings	0.5	1.0	1.8	0.2	-1.4
High blood pressure	0.5	1.5	2.6	1.6	-0.7
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.8	0.9	-0.6
Trunk fat mass	0.5	1.9	2.9	-1.7	-1.0
Number of incorrect matches in round	0.5	0.8	1.5	-1.2	-0.2
Had menopause	0.5	0.7	1.2	0.4	-1.1
Heart attack	0.5	0.6	1.2	1.1	0.3
Number of children fathered	0.5	0.5	0.9	-0.9	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.6	0.7	0.8
Medication: Ibuprofen	0.5	0.6	1.0	-1.0	-0.3
Whole body fat mass	0.5	2.0	2.4	-1.6	-1.3
Alcohol intake frequency.	0.5	1.1	1.3	-1.1	-0.9
Smoking status: Previous	0.5	0.7	1.4	0.2	-1.2
Long-standing illness, disability or infirmity	0.5	0.8	1.2	-1.1	-0.7
Friendships satisfaction	0.5	0.6	1.1	0.1	-1.1
Hearing aid user	0.5	0.6	1.0	-0.4	-1.0
Medication: Atorvastatin	0.5	0.6	0.6	-0.8	-0.8
Myopia	0.5	0.7	0.7	-0.8	0.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.2	-0.1	-1.1
Worry (Nagel 2018)	0.4	0.8	0.8	0.9	0.9
Ulcerative Colitis	0.4	0.5	1.1	1.0	-0.1
BMI	0.4	2.4	4.8	0.2	-2.2
Angina	0.4	0.6	1.1	-0.2	-1.1
Body mass index (BMI)	0.4	1.7	3.2	-0.4	-1.8
Alcohol usually taken with meals	0.4	0.7	1.3	-0.4	1.1
Nervous feelings	0.4	0.8	1.0	1.0	0.7
Asthma	0.4	0.8	1.4	-1.2	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.8	-0.9	-0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.2	1.1	-0.7
Worry too long after embarrassment	0.4	0.7	1.0	-1.0	-0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	-0.2	-1.0
Pulse rate, automated reading	0.4	1.4	2.8	1.7	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.6	-0.8	0.6
Back pain experienced in last month	0.4	0.5	1.0	-0.1	-1.0
Asthma (self-reported)	0.4	0.8	1.5	-1.2	-0.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	0.1	1.0
Medication: Blood pressure	0.4	0.7	0.8	0.9	-0.8
Average weekly beer plus cider intake	0.4	0.6	1.2	-0.0	-1.1
Age started oral contraceptive pill	0.4	0.5	1.0	1.0	0.0
Ever depressed for a whole week	0.4	0.5	1.0	1.0	0.0
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	-0.8	-0.3
LDL Cholesterol	0.3	0.4	0.9	0.9	0.1
Neuroticism (2016)	0.3	0.4	0.7	-0.3	0.8
Blood Eosinophil Count	0.3	1.9	3.0	-1.7	-1.0
Blood Platelet Count	0.3	4.0	6.4	1.2	-2.5
Heel T-Score	0.3	2.6	5.2	0.1	2.3
Hearing difficulty/problems: Yes	0.3	0.5	0.7	-0.9	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	-0.3	0.9
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.8	0.1
Townsend deprivation index at recruitment	0.3	0.4	0.8	0.9	-0.1
Stomach or abdominal pain in last month	0.3	0.4	0.7	-0.8	0.2
Hair/balding pattern: Pattern 3	0.3	0.4	0.7	-0.3	-0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.7	0.9	-0.9	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	0.2	-0.8
Mouth/teeth dental problems: Dentures	0.3	0.6	0.6	-0.8	-0.7
Birth weight of first child	0.3	0.5	1.0	1.0	-0.2
High blood pressure (siblings)	0.3	0.5	0.7	-0.5	-0.9
Exposure to tobacco smoke outside home	0.3	0.4	0.8	-0.9	-0.2
Health satisfaction	0.3	0.3	0.7	0.1	0.8
Had major operations	0.3	0.4	0.6	0.8	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.4	-0.6	-0.6
Mineral and other dietary supplements	0.3	0.5	0.6	-0.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.6	-0.7	0.8
Ever taken oral contraceptive pill	0.3	0.4	0.6	0.8	-0.4
Medication: Bendroflumethiazide	0.3	0.5	0.7	0.8	-0.5
Fractured/broken bones in last 5 years	0.3	0.4	0.9	-0.1	-0.9
Unable to work because of sickness or disability	0.3	0.3	0.7	-0.8	-0.2
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.9	-1.0	-0.2
HbA1C	0.2	0.3	0.5	-0.7	-0.1
Primary Biliary Cirrhosis	0.2	0.2	0.5	0.7	0.1
Blood Red Count	0.2	1.9	3.5	-0.6	-1.9
Number of treatments/medications taken	0.2	0.4	0.6	0.4	-0.8
Diabetes (mother)	0.2	0.2	0.3	0.4	0.5
Age when periods started (menarche)	0.2	0.4	0.5	0.7	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	0.0	1.0
Diabetes (self-reported)	0.2	0.2	0.4	-0.7	-0.2
Worrier / anxious feelings	0.2	0.4	0.7	0.8	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.2	0.8
Hair/balding pattern: Pattern 4	0.2	0.5	0.8	0.3	-0.9
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	0.4	0.5
Headache pain in last month	0.2	0.4	0.6	-0.8	0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.6	-0.0
Shortness of breath walking on level ground	0.2	0.2	0.3	0.6	0.4
Neck or shoulder pain in last month	0.2	0.3	0.3	0.5	-0.5
Angina (self-reported)	0.2	0.3	0.6	-0.0	-0.8
Medication: Seretide 50 evohaler	0.2	0.3	0.3	-0.6	0.4
Overall health rating	0.2	0.3	0.4	-0.6	-0.6
Age at last live birth	0.2	0.2	0.2	0.4	-0.5
Illnesses of father: Heart disease	0.2	0.3	0.6	-0.1	-0.8
Illnesses of siblings: Diabetes	0.2	0.2	0.5	-0.0	-0.7
Mood swings	0.2	0.4	0.5	0.6	0.7
Breast cancer (self-reported)	0.2	0.2	0.3	-0.6	-0.3
Osteoarthritis (self-reported)	0.2	0.2	0.4	0.2	0.6
Number of self-reported non-cancer illnesses	0.2	0.4	0.6	0.8	-0.4
Financial situation satisfaction	0.2	0.2	0.4	0.6	-0.4
High cholesterol (Self-reported)	0.2	0.4	0.8	0.9	-0.1
Alcohol drinker status: Never	0.2	0.3	0.4	-0.6	-0.4
Risk taking	0.2	0.4	0.7	0.2	0.8
Bipolar Disorder (2018)	0.1	0.2	0.4	0.6	0.3
Depressed Affect (Nagel 2018)	0.1	0.1	0.2	-0.3	-0.4
Depression (Nagel 2018)	0.1	0.1	0.2	0.5	0.1
Major Depression (MDD)	0.1	0.1	0.1	0.4	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.4	0.7	-0.8	0.1
Ovarian Cancer	0.1	0.1	0.1	-0.0	0.4
Prostate Cancer	0.1	0.1	0.2	-0.0	0.4
Body Mass Index (BMI) (2010)	0.1	0.1	0.1	0.4	0.4
Crohns Disease (2012)	0.1	0.2	0.3	0.6	-0.1
HDL Cholesterol	0.1	0.1	0.1	-0.4	0.3
Blood White Count	0.1	0.5	1.0	-0.1	-1.0
Allergy or Eczema	0.1	0.2	0.3	0.3	0.6
Hand grip strength (left)	0.1	0.2	0.3	-0.6	-0.1
Average weekly spirits intake	0.1	0.1	0.1	0.4	-0.2
Sensitivity / hurt feelings	0.1	0.2	0.2	0.4	0.4
Vitamin and mineral supplements	0.1	0.2	0.2	0.5	0.4
Medication: Metformin	0.1	0.1	0.1	-0.4	0.1
Average weekly fortified wine intake	0.1	0.1	0.1	-0.3	0.2
Maternal smoking around birth	0.1	0.1	0.2	-0.4	-0.4
Taking other prescription medications	0.1	0.1	0.1	0.3	-0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.2	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	0.6	0.3
Medication: Levothyroxine sodium	0.1	0.2	0.2	0.5	-0.4
High blood pressure (mother)	0.1	0.2	0.3	0.5	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.0	0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	0.3	-0.3
Medication: Ramipril	0.1	0.1	0.2	0.2	-0.4
Fluid intelligence score	0.1	0.2	0.3	-0.6	-0.1
Neuroticism score	0.1	0.2	0.3	0.6	0.1
Arm fat percentage (right)	0.1	0.5	0.7	-0.5	-0.8
Pulse wave Arterial Stiffness index	0.1	0.1	0.1	-0.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.4	0.1
Blood clot in the leg (DVT)	0.1	0.1	0.1	-0.3	0.2
Gout (self-reported)	0.1	0.1	0.2	0.4	0.4
Medication: Amlodipine	0.1	0.2	0.4	0.6	-0.2
Leg fat percentage (right)	0.1	0.3	0.6	0.0	-0.7
Age at first live birth	0.1	0.1	0.2	-0.1	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	0.1	-0.5
Medication: Allopurinol	0.1	0.1	0.2	0.2	0.4
Medication: Omeprazole	0.1	0.2	0.3	0.2	-0.5
Supplements: Vitamin C	0.1	0.1	0.2	-0.1	0.4
Arm fat percentage (left)	0.1	0.4	0.5	-0.7	-0.7
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.5	0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	0.5	-0.1
Medication for cholesterol	0.1	0.2	0.4	0.2	0.6
Miserableness	0.1	0.1	0.3	-0.1	0.5
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.2	-0.4
Number of operations (self-reported)	0.1	0.1	0.2	-0.4	-0.2
Irritability	0.1	0.2	0.4	0.1	-0.6
Cholesterol lowering medication	0.1	0.2	0.4	-0.6	-0.1
Neuroticism (Nagel 2018)	0.0	0.0	0.0	0.1	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.0	0.1	-0.2	-0.0
Rheumatoid Arthritis	0.0	0.0	0.1	-0.1	-0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	-0.0	-0.1
Lung FVC	0.0	0.2	0.3	0.1	0.6
Neuroticism	0.0	0.1	0.1	0.2	0.4
Hair Pigment	0.0	0.1	0.2	-0.4	-0.2
Tanning	0.0	0.4	0.8	0.9	0.2
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	0.2	0.0
Trunk fat percentage	0.0	0.1	0.3	-0.5	-0.0
Hand grip strength (right)	0.0	0.1	0.1	-0.3	0.1
Multivitamins +/- minerals	0.0	0.0	0.1	-0.3	0.1
Qualifications: None of the above	0.0	0.1	0.2	0.4	0.2
Financial difficulties in last 2 years	0.0	0.0	0.0	-0.2	-0.1
Allergy	0.0	0.1	0.2	0.0	0.4
Happiness	0.0	0.0	0.1	0.1	0.3
Illnesses of mother	0.0	0.0	0.1	0.1	-0.2
Body fat percentage	0.0	0.1	0.1	-0.3	-0.3
Number of full brothers	0.0	0.0	0.0	-0.1	-0.1
Pulse wave peak to peak time	0.0	0.0	0.0	0.1	-0.1
Qualifications: College or University degree	0.0	0.0	0.0	-0.0	0.0
Emphysema/chronic bronchitis	0.0	0.0	0.0	-0.0	-0.2
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	-0.3	-0.1
Diabetes diagnosed by doctor	0.0	0.0	0.0	0.1	0.2
Guilty feelings	0.0	0.1	0.1	-0.2	0.3
Leg fat percentage (left)	0.0	0.2	0.3	-0.1	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	-0.2	-0.1

Hub : Genes

AURKA

Models

Trait associations