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chr21:36,744,868-41,512,399

Best TWAS P=5.24e-16 · Best GWAS P=8.33e-32 conditioned to 1.23e-16

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CBR1	0.25	0.12	enet	29	0.20	9.5e-24	-3.8	-5.3	9.5e-08	-0.05	0.24	0.54	TRUE
2	GTEx	Adipose Subcutaneous	WRB	0.44	0.52	lasso	5	0.55	7.7e-53	5.6	5.6	2.4e-08	-0.02	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	PIGP	0.39	0.37	enet	26	0.49	2.1e-45	4.3	5.2	2.2e-07	0.01	0.09	0.82	TRUE
4	GTEx	Adipose Visceral Omentum	WRB	0.53	0.44	lasso	11	0.42	1.5e-23	5.6	5.5	3.7e-08	-0.01	0.01	0.99	FALSE
5	GTEx	Artery Aorta	WRB	0.24	0.31	lasso	3	0.30	4.2e-17	5.6	5.5	3.1e-08	-0.02	0.01	0.99	FALSE
6	GTEx	Artery Coronary	WRB	0.56	0.50	lasso	3	0.50	2.1e-19	5.5	5.5	2.9e-08	-0.02	0.01	0.99	FALSE
7	GTEx	Artery Tibial	WRB	0.57	0.58	enet	19	0.59	4.8e-56	5.6	5.4	5.7e-08	-0.02	0.01	0.99	FALSE
8	GTEx	Brain Cerebellar Hemisphere	LCA5L	0.65	0.53	lasso	7	0.49	1.8e-14	5.6	5.5	3.3e-08	-0.02	0.01	0.99	FALSE
9	GTEx	Brain Cerebellum	LCA5L	0.72	0.53	lasso	12	0.53	2.0e-18	5.6	5.5	3.2e-08	-0.01	0.01	0.99	FALSE
10	GTEx	Breast Mammary Tissue	WRB	0.38	0.38	lasso	4	0.37	4.2e-20	5.5	5.5	4.5e-08	-0.01	0.01	0.99	FALSE
11	GTEx	Cells Transformed fibroblasts	WRB	0.43	0.46	enet	23	0.48	4.0e-40	5.6	5.4	5.8e-08	-0.02	0.01	0.99	FALSE
12	GTEx	Colon Sigmoid	WRB	0.38	0.21	lasso	7	0.24	4.3e-09	5.6	5.5	4.8e-08	-0.02	0.01	0.99	FALSE
13	GTEx	Colon Transverse	WRB	0.27	0.19	lasso	5	0.17	2.1e-08	5.6	5.8	6.8e-09	-0.01	0.01	0.99	FALSE
14	GTEx	Colon Transverse	BRWD1-IT2	0.28	0.01	enet	41	0.04	8.4e-03	-4.7	6.2	5.1e-10	-0.07	0.13	0.22	TRUE
15	GTEx	Esophagus Gastroesophageal Junction	WRB	0.42	0.44	lasso	5	0.43	4.3e-17	5.6	5.6	2.6e-08	-0.02	0.01	0.99	FALSE
16	GTEx	Esophagus Mucosa	WRB	0.29	0.33	lasso	2	0.32	3.4e-22	5.6	5.6	2.6e-08	-0.01	0.01	0.99	FALSE
17	GTEx	Esophagus Muscularis	WRB	0.34	0.38	lasso	5	0.39	7.1e-25	5.6	5.6	2.4e-08	-0.02	0.01	0.99	FALSE
18	GTEx	Lung	WRB	0.29	0.22	enet	13	0.24	1.9e-18	5.6	5.2	2.1e-07	-0.04	0.01	0.99	FALSE
19	GTEx	Nerve Tibial	WRB	0.47	0.43	lasso	4	0.43	3.5e-33	5.6	5.7	1.2e-08	-0.02	0.01	0.99	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	WRB	0.35	0.31	lasso	3	0.31	1.4e-17	5.6	5.6	2.4e-08	-0.01	0.01	0.99	FALSE
21	GTEx	Skin Sun Exposed Lower leg	WRB	0.34	0.37	lasso	5	0.36	1.8e-31	5.6	5.6	2.3e-08	-0.02	0.01	0.99	FALSE
22	GTEx	Uterus	LCA5L	0.55	0.27	enet	10	0.26	4.9e-06	5.6	5.5	4.0e-08	-0.02	0.01	0.99	FALSE
23	GTEx	Uterus	WRB	0.39	0.28	lasso	4	0.24	1.4e-05	5.6	5.6	2.3e-08	-0.02	0.01	0.98	FALSE
24	GTEx	Whole Blood	WRB	0.22	0.12	lasso	7	0.11	3.0e-10	5.4	5.8	5.9e-09	-0.01	0.01	0.99	FALSE
25	METSIM	Adipose	KCNJ15	0.05	0.03	lasso	5	0.02	6.8e-04	-7.5	8.1	7.3e-16	-0.65	0.77	0.17	FALSE
26	METSIM	Adipose	WRB	0.18	0.27	lasso	7	0.27	5.7e-40	5.3	5.5	2.9e-08	-0.01	0.01	0.99	FALSE
27	NTR	Blood	KCNJ15	0.06	0.09	lasso	4	0.09	7.0e-27	-7.3	7.4	1.3e-13	-0.65	1.00	0.00	FALSE
28	NTR	Blood	LCA5L	0.04	0.04	bslmm	718	0.03	4.5e-11	5.6	5.7	1.0e-08	-0.01	0.01	0.99	FALSE
29	NTR	Blood	WRB	0.07	0.07	enet	13	0.08	5.9e-24	5.3	5.7	1.5e-08	-0.02	0.01	0.99	FALSE
30	YFS	Blood	KCNJ15	0.22	0.29	enet	19	0.30	3.9e-100	-7.6	7.8	7.7e-15	-0.66	1.00	0.00	FALSE
31	YFS	Blood	PSMG1	0.06	0.06	lasso	4	0.07	1.1e-21	-4.7	-5.3	1.2e-07	-0.01	0.40	0.60	FALSE
32	YFS	Blood	WRB	0.20	0.29	enet	18	0.29	8.4e-95	5.6	5.5	5.0e-08	-0.02	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	WRB	0.05	0.07	lasso	2	0.06	5.7e-04	5.6	5.6	2.3e-08	-0.02	0.01	0.98	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	CBR1	0.45	0.09	lasso	5	0.22	5.1e-13	2.4	-5.1	2.9e-07	-0.02	0.02	0.55	FALSE
35	The Cancer Genome Atlas	Colon Adenocarcinoma	WRB	0.06	0.07	lasso	1	0.05	1.1e-03	5.4	5.4	6.7e-08	-0.03	0.01	0.92	FALSE
36	The Cancer Genome Atlas	Esophageal Carcinoma	WRB	0.16	0.12	lasso	2	0.12	1.1e-04	5.6	5.6	2.3e-08	-0.01	0.01	0.93	FALSE
37	The Cancer Genome Atlas	Glioblastoma Multiforme	HMGN1	0.19	0.04	blup	43	0.08	2.1e-03	4.8	-5.6	2.1e-08	0.01	0.02	0.71	FALSE
38	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	WRB	0.11	0.12	enet	6	0.12	2.5e-07	5.6	5.5	3.2e-08	-0.02	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	WRB	0.17	0.32	enet	11	0.31	4.6e-36	5.6	5.4	7.0e-08	-0.01	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	WRB	0.07	0.07	lasso	3	0.06	7.7e-08	5.6	5.6	2.8e-08	-0.02	0.00	1.00	FALSE
41	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	WRB	0.05	0.04	lasso	7	0.06	3.1e-07	5.5	6.5	7.4e-11	-0.01	0.01	0.99	TRUE
42	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	WRB	0.08	0.07	blup	48	0.06	7.6e-05	5.6	6.1	9.8e-10	-0.03	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	WRB	0.08	0.08	lasso	4	0.08	6.1e-09	5.6	5.8	7.5e-09	-0.02	0.01	0.99	FALSE
44	The Cancer Genome Atlas	Skin Cutaneous Melanoma	WRB	0.12	0.06	blup	48	0.10	1.2e-03	3.0	5.1	2.8e-07	0.00	0.01	0.68	TRUE
45	The Cancer Genome Atlas	Stomach Adenocarcinoma	WRB	0.09	0.08	lasso	2	0.07	8.6e-06	5.6	5.6	1.6e-08	-0.02	0.00	0.99	FALSE
46	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DSCR10	0.07	0.03	blup	35	0.06	3.0e-03	7.0	-8.1	5.2e-16	0.67	0.02	0.66	TRUE
47	The Cancer Genome Atlas	Thyroid Carcinoma	CBR1	0.46	0.13	enet	18	0.20	3.5e-19	2.4	-5.2	1.9e-07	-0.03	0.05	0.02	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	KCNJ15	0.09	0.05	blup	66	0.05	1.3e-05	3.6	5.3	1.5e-07	-0.38	0.16	0.14	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	WRB	0.13	0.25	lasso	8	0.26	4.2e-25	5.6	5.5	4.5e-08	-0.02	0.00	1.00	FALSE