Best TWAS P=2.94e-16 · Best GWAS P=5.59e-20 conditioned to 6.94e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | COL8A1 | 0.19 | 0.01 | lasso | 8 | 0.05 | 1.7e-04 | 3.75 | -6.3 | 2.4e-10 | -0.30 | 0.83 | 0.16 | TRUE |
| 2 | GTEx | Nerve Tibial | DCBLD2 | 0.14 | 0.05 | lasso | 5 | 0.03 | 1.7e-03 | 6.02 | 7.9 | 2.1e-15 | 0.28 | 0.16 | 0.44 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | ST3GAL6 | 0.07 | 0.04 | enet | 16 | 0.04 | 2.0e-04 | 3.74 | 5.2 | 1.9e-07 | 0.24 | 0.58 | 0.23 | FALSE |
| 4 | GTEx | Thyroid | DCBLD2 | 0.14 | 0.12 | lasso | 5 | 0.15 | 1.5e-11 | -5.43 | 6.0 | 2.3e-09 | 0.18 | 1.00 | 0.00 | FALSE |
| 5 | METSIM | Adipose | CPOX | 0.09 | 0.02 | blup | 456 | 0.05 | 6.4e-08 | -0.16 | -6.0 | 1.5e-09 | -0.05 | 0.59 | 0.40 | FALSE |
| 6 | METSIM | Adipose | ST3GAL6 | 0.05 | 0.00 | bslmm | 412 | 0.03 | 4.5e-05 | 4.78 | 5.4 | 6.2e-08 | 0.01 | 0.06 | 0.55 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DCBLD2 | 0.09 | 0.01 | enet | 16 | 0.04 | 9.6e-05 | 6.46 | 8.2 | 2.9e-16 | 0.23 | 0.06 | 0.73 | TRUE |