Hub : Genes

CPOX

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.2190	0.0570	1.6e-05	0.034	NA	0.017	NA	0.041	0.00140	NA	1.8e-02	NA	4.7e-04
2	METSIM	Adipose	0.0864	0.0251	9.6e-07	0.019	0.049	0.045	0.048	0.039	0.00062	6.4e-08	2.2e-07	8.1e-08	1.4e-06
3	TCGA	Colon Adenocarcinoma	0.1020	0.0480	1.9e-03	0.003	0.025	0.012	NA	0.023	0.21000	1.3e-02	6.6e-02	NA	1.6e-02
4	TCGA	Prostate Adenocarcinoma	0.0650	0.0275	1.9e-04	0.034	0.039	0.011	NA	0.026	0.00016	5.9e-05	2.1e-02	NA	9.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.2	0.7	0.0	0.2	-0.1	-0.8
Bipolar Disorder or Schizophrenia	1.0	2.5	5.1	-0.5	1.8	-2.3	-1.1
Depressed Affect (Nagel 2018)	0.2	0.5	0.7	0.8	-0.1	-0.8	0.8
Depression (Nagel 2018)	0.8	1.1	3.7	0.8	-0.1	1.9	0.5
Intelligence (Savage-Jansen 2018)	0.9	2.8	7.1	-2.7	-0.4	0.2	-1.9
Neuroticism (Nagel 2018)	0.5	1.2	2.9	1.7	0.8	-0.2	1.0
Schizophrenia (2018)	1.6	3.4	7.8	-0.6	2.2	-2.8	-0.8
Schizophrenia vs Biploar Disorder	1.2	1.6	2.7	1.6	1.3	-0.3	1.4
Worry (Nagel 2018)	0.8	1.8	3.0	1.6	1.2	-0.3	1.7
Alzheimer’s Disease (in mother)	0.9	1.1	3.1	1.0	-1.8	0.2	-0.6
Alzheimer’s Disease (in father)	2.2	2.4	5.3	-0.4	-2.3	1.3	-1.5
Alzheimer’s Disease (including proxy)	1.7	2.5	6.6	0.8	-2.6	0.9	-1.3
Crohns Disease (2017)	0.2	0.5	1.3	-0.2	-0.8	1.2	-0.3
Irritable Bowel Disease (IBD)	1.2	2.8	5.9	-1.3	-1.7	0.9	-2.4
Ulcerative Colitis (UC)	1.9	3.6	8.8	-1.8	-1.6	-0.1	-3.0
Major Depression (MDD)	0.4	0.4	1.1	-1.1	0.5	-0.4	-0.4
Reaction Time	0.2	0.4	0.8	0.5	-0.5	-0.9	-0.4
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.3	-1.8	0.3	0.5	-1.2
Breast Cancer	1.0	2.4	7.0	0.4	2.6	-1.6	0.3
Ovarian Cancer	0.4	0.5	1.4	-0.5	1.2	0.1	-0.7
Prostate Cancer	1.5	2.1	3.8	1.0	-1.5	1.9	1.2
Age at First Birth	0.5	0.7	2.2	0.2	1.5	-0.6	0.3
Bipolar Disorder (2011)	1.0	0.9	3.1	-1.8	0.8	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.0	-0.8	0.7	-1.0	0.0
Coronary Artery Disease (CAD)	0.4	0.5	1.8	0.3	1.3	-0.4	-0.3
Crohns Disease (2012)	0.6	1.0	2.8	0.3	-1.7	1.0	-0.3
Mean Putamen Volume	0.3	0.4	0.7	0.8	0.4	0.3	0.6
Fasting Glucose	0.2	0.3	0.9	0.2	-0.0	1.0	-0.3
HbA1C	0.5	0.5	1.0	-0.8	0.4	1.0	0.6
HDL Cholesterol	1.2	2.0	5.9	2.4	0.7	-1.2	0.6
LDL Cholesterol	0.3	0.5	1.2	0.7	0.6	-1.1	0.2
Lupus	1.0	1.5	2.8	1.7	0.6	1.3	1.0
Neuroticism (2016)	0.3	0.5	1.5	-0.5	1.2	-0.5	-0.0
Primary Biliary Cirrhosis	2.6	3.7	5.4	-2.3	-1.3	1.9	-2.1
Rheumatoid Arthritis	0.4	0.5	1.6	0.2	1.2	0.1	-0.6
Schizophrenia (2014)	0.7	1.4	3.4	0.1	1.4	-1.8	-0.6
Triglycerides	1.4	2.2	4.1	-2.0	1.6	-1.3	0.8
Type 2 Diabetes (T2D) (2012)	2.2	2.6	7.7	-2.8	1.3	-1.0	-0.4
Ulcerative Colitis	2.2	3.2	8.9	-1.4	-1.2	-0.7	-3.0
Blood Eosinophil Count	0.7	5.7	8.9	2.8	3.0	-0.9	2.2
Blood Platelet Count	0.1	0.8	2.4	-0.1	-1.5	0.2	-0.9
Blood Red Count	0.2	2.1	5.3	-0.1	-1.2	2.3	-1.2
Blood White Count	0.6	4.4	13.6	-3.7	1.5	0.7	-1.1
Heel T-Score	0.1	0.9	2.0	-1.1	0.3	0.5	-1.4
BMI	0.2	1.4	4.6	-2.1	-0.6	0.5	-0.5
Height	1.5	28.1	63.7	5.6	-8.0	3.9	1.5
Waist Hip Ratio (WHR)	0.0	0.1	0.1	0.4	0.2	0.3	0.2
Systolic Blood Pressure	0.3	1.5	4.8	-2.2	0.9	0.2	-0.3
Smoking Status	0.5	1.3	2.1	1.4	0.9	0.6	1.4
Allergy or Eczema	0.3	0.8	1.7	-1.3	0.7	-0.8	-0.6
Cardiovascular Disease	0.3	1.0	3.0	-0.2	-0.8	1.7	0.4
Hypothyroidism (self reported)	0.7	1.5	1.7	1.3	1.3	-1.1	1.3
Respiratory disease	0.8	1.7	2.3	-1.2	1.3	-1.2	-1.5
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.6	-0.6	0.2	1.3	-0.1
Lung FEV1/FVC ratio	0.4	1.9	3.7	0.8	-1.9	1.8	-0.1
Lung FVC	1.0	5.2	8.2	-2.9	-1.2	2.6	-2.2
Neuroticism	0.2	0.4	0.8	0.9	0.6	-0.4	0.4
Chronotype (morning person)	0.2	0.5	1.6	-1.3	-0.5	0.4	-0.4
Hair Pigment	0.0	0.6	1.1	-0.7	1.0	0.8	0.1
Tanning	0.1	1.2	3.7	1.9	0.8	0.2	0.7
Hand grip strength (left)	0.6	1.7	2.9	1.3	-1.7	-0.5	-1.3
Number of treatments/medications taken	0.3	0.5	1.2	-1.1	0.6	0.3	-0.7
Average weekly spirits intake	0.1	0.1	0.2	-0.4	-0.2	-0.2	-0.0
Sensitivity / hurt feelings	1.2	2.1	7.3	2.7	0.5	0.4	0.9
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.7	1.3	-0.4	0.8	1.1
Hearing difficulty/problems: Yes	0.6	1.0	3.2	0.7	-0.2	1.8	0.4
Relative age of first facial hair	0.5	1.1	2.1	-0.9	0.6	-1.1	-1.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	-0.4	-0.6	0.4	-0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.4	1.0	-1.2	0.3	-0.4
Ever had hysterectomy (womb removed)	4.4	5.0	13.8	-2.2	-1.1	-0.2	-3.7
Systolic blood pressure, automated reading	0.2	0.7	1.9	-1.4	0.9	-0.3	0.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.0	-1.4	-0.2	-0.1	-0.6
Angina	0.6	0.8	1.6	0.2	1.3	-0.4	1.1
Medication for hormone replacement therapy	1.9	2.1	7.5	2.7	-0.8	-0.0	-0.6
Vitamin and mineral supplements	0.3	0.5	1.3	0.4	-0.4	-1.2	-0.4
Supplements: Zinc	0.8	0.8	1.5	-0.9	0.3	1.2	-1.0
Medication: Co-codamol	1.7	2.0	6.2	0.6	-1.2	2.5	-0.1
Medication: Metformin	1.7	2.4	6.7	0.7	-1.6	2.6	-0.1
Diabetes (father)	0.5	0.6	1.6	1.3	0.8	-0.2	0.1
Diabetes (mother)	0.6	0.8	1.3	1.2	-1.0	-0.9	-0.2
Severe depression (siblings)	0.6	0.6	1.3	-0.1	0.6	-1.1	1.0
Pack years adult smoking proportion	0.3	0.4	0.9	-0.9	0.9	0.1	0.1
Impedance of leg (right)	1.6	7.6	18.1	4.2	2.1	-0.6	2.7
Leg fat-free mass (left)	1.3	6.9	17.7	-0.2	-4.2	3.1	-0.1
Trunk fat percentage	0.3	1.1	2.8	1.1	-0.3	1.7	0.5
Hand grip strength (right)	1.1	3.0	7.0	1.1	-2.6	-0.5	-1.9
Townsend deprivation index at recruitment	0.2	0.3	1.0	0.4	-1.0	-0.2	-0.5
Current tobacco smoking	1.0	1.6	4.1	0.6	2.0	0.1	1.4
Average weekly fortified wine intake	1.0	1.2	1.5	-1.2	1.2	-1.2	-0.6
Maternal smoking around birth	2.1	3.1	10.0	0.7	1.3	-3.2	0.1
Fed-up feelings	0.9	1.7	4.1	1.2	0.9	-2.0	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.9	0.9	-0.6	1.0	0.2
Relative age voice broke	0.6	1.0	2.1	-0.4	-1.0	-1.4	-0.8
Taking other prescription medications	0.3	0.5	0.9	-0.9	0.9	0.3	0.1
Age when periods started (menarche)	0.7	1.7	5.0	0.3	1.3	-2.2	0.0
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	4.7	-0.8	0.9	0.2	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.9	-1.7	1.0	-0.8	-0.5
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	3.4	1.1	-0.3	0.6	1.8
Qualifications: CSEs or equivalent	0.2	0.3	0.4	0.6	0.1	0.6	0.5
Serious illness, injury or assault to yourself	0.6	0.8	1.7	0.3	1.3	-0.0	1.2
High blood pressure	0.3	0.9	1.8	-0.3	-1.3	1.3	-0.5
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.2	-1.8	1.4	-1.2	-0.7
Multivitamins +/- minerals	0.2	0.2	0.5	-0.7	0.2	0.6	-0.3
Stomach or abdominal pain in last month	1.5	1.8	3.0	1.7	0.8	-0.9	1.7
Supplements: Glucosamine	0.1	0.1	0.4	-0.6	-0.0	0.1	-0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	0.8	-0.7	0.9	0.5
Medication: Atenolol	0.6	0.8	2.0	-1.4	0.9	-0.5	0.0
Medication: Levothyroxine sodium	0.8	1.4	4.2	1.2	0.3	-0.2	2.0
Sitting height	2.2	15.8	27.7	5.3	-4.5	3.2	2.3
Chronic bronchitis/emphysema (father)	1.1	1.3	4.0	2.0	-0.6	-0.0	0.9
High blood pressure (mother)	0.8	1.1	3.1	-0.8	0.8	0.0	1.8
Body mass index (BMI)	0.1	0.6	1.0	-1.0	-0.8	0.8	0.1
Impedance of leg (left)	1.6	7.7	19.9	4.5	1.9	-0.6	2.7
Leg predicted mass (left)	1.3	6.9	17.9	-0.2	-4.2	3.1	-0.1
Trunk fat mass	0.5	2.1	4.5	1.3	-1.4	2.1	0.5
Waist circumference	0.3	1.1	2.5	-0.3	-1.6	1.4	-0.2
Number of incorrect matches in round	0.7	1.2	2.5	-0.7	-0.9	-1.1	-1.6
Past tobacco smoking	0.3	0.6	1.5	-1.2	-0.3	0.8	-0.5
Alcohol usually taken with meals	1.6	2.6	6.0	-0.5	-2.0	0.4	-2.5
Nervous feelings	1.4	2.5	5.7	0.1	2.4	-1.4	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.3	1.5	0.3	-0.3	0.6
Hearing difficulty/problems with background noise	2.3	3.7	5.7	2.2	-0.2	2.4	2.1
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	0.3	-0.9	-0.6	-0.7
Had menopause	0.8	1.0	2.4	1.3	0.3	1.5	0.3
Had other major operations	0.8	1.0	1.7	-0.8	-1.3	-0.4	-1.3
Forced vital capacity (FVC)	1.4	5.3	15.8	-0.4	-4.0	1.8	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.0	-1.4	0.6	-1.3	-0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.6	-0.8	-0.4	1.3	0.6
Qualifications: None of the above	0.1	0.2	0.6	-0.7	0.1	0.4	0.2
Financial difficulties in last 2 years	0.2	0.2	0.5	-0.0	-0.7	0.1	-0.7
Mouth/teeth dental problems	0.9	1.4	3.3	0.7	-1.3	1.8	0.4
Heart attack	0.3	0.3	0.8	-0.3	0.9	-0.6	0.1
Allergy	1.1	2.6	5.6	1.4	-2.4	1.6	0.1
Pain all over the body in last month	1.6	1.8	5.6	-0.4	-2.4	1.1	0.2
Diabetes (self-reported)	1.1	1.6	5.4	-0.8	-0.2	2.3	-0.6
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	-0.5	0.2	0.3	0.7
Medication: Ramipril	0.3	0.4	0.6	-0.8	-0.6	-0.4	-0.7
Medication: Simvastatin	0.2	0.3	0.3	-0.5	0.5	0.4	-0.6
Fluid intelligence score	0.4	0.8	1.9	-1.4	1.0	0.6	-0.3
Illnesses of siblings	0.1	0.2	0.4	0.5	-0.1	0.7	0.3
Neuroticism score	1.0	2.1	3.8	1.9	1.2	-0.2	1.7
Weight	0.9	4.6	11.6	0.8	-3.4	2.5	0.4
Impedance of arm (right)	0.2	0.8	2.5	0.8	1.6	-0.1	-0.1
Arm fat percentage (right)	0.1	0.4	1.0	-1.0	-0.1	0.6	-0.3
Trunk fat-free mass	1.6	9.5	27.8	1.1	-5.3	3.0	0.2
Hip circumference	0.3	1.1	3.7	-0.3	-1.9	0.8	-0.1
Time employed in main current job	0.3	0.3	0.7	-0.7	-0.4	-0.1	-0.8
Alcohol intake versus 10 years previously	0.7	1.0	1.8	1.1	-1.4	0.2	1.1
Father’s age at death	2.7	3.6	7.2	-2.7	-0.2	-0.6	-2.6
Worrier / anxious feelings	1.6	3.1	9.2	3.0	-0.7	1.3	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	0.1	0.3	0.8	0.1
Falls in the last year	0.1	0.2	0.5	-0.3	0.0	-0.1	-0.7
Hair/balding pattern: Pattern 3	0.1	0.2	0.2	0.3	-0.5	0.5	-0.2
Number of live births	0.4	0.5	0.7	-0.9	0.6	0.5	-0.8
Forced expiratory volume in 1-second (FEV1)	1.7	5.8	17.0	-0.4	-4.1	2.0	-1.4
Pulse rate	0.9	1.5	2.4	1.3	-1.6	1.4	0.0
Happiness	0.4	0.5	1.7	-1.3	0.4	-0.4	-0.1
Noisy workplace	0.4	0.4	0.7	-0.7	-0.8	0.0	-0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.7	-1.3	0.3	0.4	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.0	0.6	0.1	-0.3	-1.0
Mouth/teeth dental problems: Dentures	0.9	1.6	3.1	-1.2	1.8	-1.3	-0.2
Asthma	0.8	1.7	2.7	-1.3	1.6	-1.5	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.3	0.6	0.4	0.1	0.5
Medication: Cholesterol lowering	0.6	0.9	3.1	0.4	0.7	1.8	0.1
Depression (self-reported)	1.5	1.8	2.8	-1.0	1.7	-1.0	-1.6
Medication: Lansoprazole	1.8	2.1	4.4	-0.6	2.1	-0.7	1.7
Prospective memory result	0.6	0.7	2.2	0.3	-1.5	0.6	-0.1
Lung cancer (father)	0.2	0.2	0.5	-0.5	-0.7	0.3	-0.0
Illnesses of mother	0.5	0.6	1.0	0.2	1.0	0.9	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.2	17.2	-1.1	-4.2	1.6	-2.0
Pulse wave Arterial Stiffness index	0.3	0.4	1.1	0.7	0.1	-1.0	0.1
Impedance of arm (left)	0.2	0.9	2.6	1.0	1.6	0.1	-0.2
Arm fat mass (right)	0.4	1.5	3.8	-0.1	-1.9	1.5	-0.1
Trunk predicted mass	1.7	9.8	28.1	1.2	-5.3	3.1	0.3
Standing height	1.8	18.0	36.5	4.1	-6.0	4.2	0.9
Length of working week for main job	0.4	0.5	0.9	1.0	0.0	0.3	0.9
Exposure to tobacco smoke at home	1.6	1.8	2.8	1.2	1.7	-1.1	1.3
Breastfed as a baby	1.4	1.8	3.0	-1.7	1.0	-0.6	-1.6
Tense / ‘highly strung’	1.4	2.3	5.3	2.3	1.1	-0.3	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.1	0.2	-0.6	-0.9
Hair/balding pattern: Pattern 4	1.0	2.5	6.1	0.4	1.9	0.2	2.5
Birth weight of first child	2.8	5.1	12.2	-1.9	-2.1	0.2	-3.5
Peak expiratory flow (PEF)	2.0	4.7	13.6	0.1	-3.7	1.9	-1.3
Pulse wave reflection index	0.8	1.0	2.5	0.7	-0.7	-1.6	-0.7
Ever highly irritable/argumentative for 2 days	0.6	0.8	2.7	0.5	0.4	0.0	1.6
Loud music exposure frequency	0.3	0.3	0.4	-0.6	0.5	-0.6	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.3	-0.2	1.2	0.1	0.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	1.7	1.2	1.3	-0.9	0.9
Blood clot in the leg (DVT)	1.1	1.4	2.6	-1.1	1.3	1.6	-0.0
Medication: Paracetamol	0.4	0.7	1.4	0.9	0.1	-1.2	0.8
Headache pain in last month	0.7	1.2	2.4	0.2	1.4	-1.6	-0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.3	-0.8	-1.1	-0.6	-0.4
Glaucoma (self-reported)	0.4	0.5	1.4	-0.4	-1.2	-0.5	-0.2
Gout (self-reported)	1.0	1.4	2.5	1.0	1.3	-0.8	1.6
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	6.2	1.8	1.1	-0.5	2.5
Medication: Amlodipine	0.7	1.0	3.9	0.4	0.1	2.0	-0.2
Medication: Ventolin 100micrograms inhaler	3.1	4.0	6.5	-2.5	1.4	-2.4	-1.2
Birth weight	0.2	0.4	0.7	-0.7	0.8	-0.2	0.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.2	0.3	0.1	-1.5	0.1
High blood pressure (siblings)	0.1	0.2	0.4	-0.3	0.6	0.2	0.6
Forced vital capacity (FVC), Best measure	1.6	5.9	16.4	-0.9	-4.0	1.6	-1.9
Body fat percentage	0.2	0.7	1.7	0.8	-0.2	1.3	0.5
Leg fat percentage (right)	0.3	1.0	2.1	1.4	0.5	0.5	1.2
Arm fat-free mass (right)	1.7	8.5	21.4	1.6	-4.6	3.0	0.8
Exposure to tobacco smoke outside home	0.0	0.0	0.1	0.1	0.3	0.1	0.3
Comparative body size at age 10	0.7	2.0	6.4	-2.5	1.2	-0.1	-0.4
Number of full brothers	0.4	0.5	1.7	1.3	0.2	-0.6	-0.2
Worry too long after embarrassment	1.5	2.4	6.8	2.6	-0.4	1.3	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.0	-1.3	1.4	-0.4	-1.1
Wheeze or whistling in the chest in last year	0.4	0.8	2.5	-0.5	1.6	-0.0	-0.7
Number of children fathered	0.9	1.0	2.2	1.5	0.4	0.1	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.6	1.3	-0.2	0.1	-0.8
Age at first live birth	0.1	0.2	0.7	-0.4	-0.8	-0.3	-0.1
Pulse wave peak to peak time	0.5	0.6	2.0	-0.4	-0.5	1.4	-0.1
Health satisfaction	0.6	0.8	1.9	-0.6	0.9	0.2	1.4
Shortness of breath walking on level ground	0.7	0.8	2.1	0.0	1.1	-0.0	1.4
Qualifications: College or University degree	1.0	3.1	7.4	-0.1	-1.4	1.8	-2.7
Eye problems/disorders: None of the above	0.3	0.3	0.7	0.8	0.1	-0.7	-0.4
Mouth/teeth dental problems: Loose teeth	1.8	2.2	4.1	0.4	2.0	-2.0	0.6
Emphysema/chronic bronchitis	2.0	2.3	4.6	0.3	2.1	-1.6	-1.4
Medication for pain relief, constipation, heartburn	0.3	0.5	1.5	-0.6	-0.3	1.2	-0.1
Neck or shoulder pain in last month	1.0	1.5	1.9	1.2	-1.3	0.9	1.4
Medication: Blood pressure	0.1	0.2	0.6	-0.0	0.3	0.0	-0.8
Angina (self-reported)	0.7	0.9	2.1	-0.1	1.4	-0.4	1.2
Migraine (self-reported)	1.7	2.1	6.6	-2.6	0.6	-0.9	-0.8
Medication: Ibuprofen	0.1	0.1	0.3	0.5	0.2	0.2	0.2
Medication: Allopurinol	0.4	0.5	1.0	0.6	1.0	-0.5	0.7
Medication: Omeprazole	1.4	1.7	3.8	0.8	-1.5	2.0	-0.1
Medication: Seretide 50 evohaler	0.7	0.8	2.6	-0.1	-0.4	0.6	-1.6
Mean time to correctly identify matches	0.1	0.1	0.2	0.4	0.3	-0.4	0.1
Heart disease (mother)	0.2	0.3	0.5	-0.4	-0.5	0.5	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	4.0	-0.7	0.7	-2.0	0.3
Whole body fat mass	0.4	1.7	3.3	0.8	-1.6	1.8	0.4
Leg fat mass (right)	0.3	1.1	1.4	1.0	-0.9	1.2	1.1
Arm predicted mass (right)	1.7	8.8	22.7	1.7	-4.8	3.0	0.6
Pulse rate, automated reading	1.0	3.4	4.7	2.1	-2.1	2.2	0.1
Alcohol intake frequency.	0.5	1.2	1.9	-0.5	-1.4	1.0	1.3
Comparative height size at age 10	3.2	17.7	29.9	4.4	-5.5	4.6	0.3
Number of full sisters	0.5	0.6	1.2	-0.2	-0.1	-1.0	-1.1
Suffer from ‘nerves’	0.3	0.5	0.7	0.8	0.7	-0.4	0.9
Overall health rating	0.8	1.7	2.0	-1.3	1.1	1.3	1.4
Chest pain or discomfort	0.9	1.3	2.8	1.1	0.4	1.7	1.1
Had major operations	1.0	1.2	3.5	0.9	-1.9	0.2	-0.7
Age at last live birth	0.5	0.7	1.9	-0.8	0.4	-1.4	-0.6
Family relationship satisfaction	1.9	2.4	3.8	-2.0	1.7	-1.7	-0.2
Leg pain on walking	0.8	1.0	2.8	1.7	0.2	0.2	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	4.1	1.4	-2.0	0.8	1.1
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.2	-1.1	0.7	0.4	0.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.2	-0.1	-0.3	1.5	-0.7
Medication: Aspirin	0.2	0.2	0.6	-0.1	-0.5	-0.0	-0.8
Supplements: Vitamin C	1.2	1.4	3.1	-0.5	1.8	0.1	1.4
Knee pain experienced in last month	0.2	0.3	0.7	0.9	-0.4	-0.2	-0.3
Hypertension (Self-reported)	0.3	0.9	2.2	-0.4	-1.0	1.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.4	0.6	-0.4	-0.6	-0.7
Illnesses of father: Heart disease	0.6	0.8	1.7	-0.7	0.5	0.8	-1.3
Illnesses of siblings: Diabetes	0.2	0.3	0.6	0.2	0.0	-0.8	-0.8
Smoking status: Previous	0.2	0.3	0.8	0.6	-0.1	-0.9	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	6.9	2.6	-2.3	1.1	1.0
Whole body fat-free mass	1.6	9.0	24.8	0.8	-5.0	3.2	0.3
Leg fat-free mass (right)	1.3	7.0	18.6	-0.4	-4.3	3.0	-0.2
Arm fat percentage (left)	0.1	0.4	1.0	-1.0	-0.1	0.6	-0.5
Average weekly red wine intake	0.6	0.8	1.9	-1.4	-0.2	0.7	-0.9
Handedness (chirality/laterality): Left-handed	1.8	2.2	4.0	0.9	1.9	-0.3	2.0
Mood swings	1.2	2.2	4.9	1.1	1.2	-1.0	2.2
Loneliness, isolation	0.1	0.2	0.5	0.7	-0.2	0.5	-0.1
Long-standing illness, disability or infirmity	0.5	0.7	1.4	0.6	0.0	1.1	1.2
Ever had bowel cancer screening	0.8	1.0	1.7	1.3	-1.0	1.1	-0.1
Diabetes diagnosed by doctor	0.7	1.2	4.7	0.1	-0.1	2.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.5	-0.2	-0.8	-0.2
Friendships satisfaction	0.1	0.2	0.4	-0.3	-0.4	0.3	-0.6
Qualifications: nursing, teaching	1.3	2.0	3.2	-1.8	1.7	-1.3	-0.2
Commuting to job workplace: Walk	2.2	2.4	7.8	-0.9	2.8	-1.0	0.1
Eye problems/disorders: Cataract	0.2	0.2	0.5	0.2	-0.4	0.7	0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.3	-0.7	0.6	-1.5	-0.4
Medication for cholesterol	1.1	1.6	3.1	-1.0	1.2	-1.8	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.4	4.0	7.1	2.7	-2.3	1.6	0.7
Back pain experienced in last month	0.9	1.3	2.6	1.5	-0.6	1.6	0.1
Mineral and other dietary supplements	0.3	0.4	1.4	0.3	-1.2	0.3	-0.3
Breast cancer (self-reported)	1.3	1.6	5.9	0.4	0.0	2.4	0.6
Asthma (self-reported)	0.7	1.5	2.4	-1.2	1.6	-1.4	-0.1
Osteoporosis (self-reported)	1.7	2.1	6.1	-0.4	1.4	0.5	2.5
Osteoarthritis (self-reported)	1.2	1.6	4.7	-1.1	-2.2	0.5	-0.4
Medication: Aspirin	0.1	0.2	0.7	0.2	0.1	-0.0	-0.9
Medication: Gliclazide	1.0	1.1	3.9	0.6	-0.5	2.0	0.1
Illnesses of father: None of the above (group 1)	1.5	1.9	3.6	-1.9	-0.3	-1.6	-1.2
Smoking status: Current	1.2	1.9	3.8	0.8	2.0	0.3	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	-0.7	-0.3	0.6	-0.2
Whole body water mass	1.5	8.7	24.7	0.7	-5.0	3.1	0.1
Leg predicted mass (right)	1.3	6.9	17.9	-0.4	-4.2	3.1	-0.2
Arm fat mass (left)	0.3	1.2	2.9	-0.0	-1.7	1.4	-0.0
Number of self-reported non-cancer illnesses	0.5	0.9	2.4	-1.6	0.9	-0.5	-0.2
Average weekly champagne plus white wine intake	1.3	1.8	3.9	-1.7	-0.5	-0.4	-2.0
Miserableness	0.9	1.6	3.4	1.8	0.4	-0.3	1.7
Guilty feelings	0.2	0.3	0.5	0.7	0.5	-0.5	-0.1
Wears glasses or contact lenses	0.9	1.0	2.1	-1.3	0.4	0.4	-1.5
Ever taken oral contraceptive pill	0.5	0.6	1.6	-0.4	0.7	-0.2	1.3
Hearing aid user	2.3	2.6	6.9	-1.8	2.6	-0.1	0.7
Mother’s age at death	0.4	0.5	1.1	-0.2	-0.6	1.1	-0.8
Financial situation satisfaction	0.7	0.9	1.4	-1.2	0.8	-1.2	0.4
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.1	-0.1	-1.5	1.4	-1.1
Commuting to job workplace: Public transport	1.1	1.3	2.2	1.5	-1.4	0.7	-0.8
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	-0.7	0.1	-0.7	0.5
Medication: Blood pressure	0.8	1.6	3.0	-1.1	-1.4	1.7	0.5
Pain type(s) experienced in last month: Hip pain	2.0	2.6	7.4	-0.3	1.0	1.4	2.7
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	0.5	0.5	0.2	0.7
High cholesterol (Self-reported)	0.1	0.2	0.5	0.6	0.0	0.2	-0.7
Medication: Bendroflumethiazide	0.3	0.5	1.0	-1.0	0.4	-0.6	-0.6
Medication: Paracetamol	0.3	0.5	0.9	0.6	-0.0	-1.0	0.8
Medication: Lisinopril	0.2	0.3	0.7	-0.6	-0.1	0.8	-0.3
Medication: Atorvastatin	0.6	0.7	1.8	-0.8	-0.7	1.3	-0.1
Illnesses of father: High blood pressure	1.3	1.6	3.9	0.8	1.3	0.3	2.0
Alcohol drinker status: Never	1.8	2.2	4.5	-1.9	2.1	-0.6	0.2
Ever smoked	0.4	0.6	1.5	0.6	0.6	-1.2	-0.5
Basal metabolic rate	1.5	8.1	22.8	0.8	-4.8	3.0	0.3
Leg fat percentage (left)	0.3	1.2	2.5	1.6	0.3	0.7	1.2
Arm fat-free mass (left)	1.8	9.2	22.5	2.0	-4.7	3.1	1.0
Number of operations (self-reported)	1.4	2.0	3.8	-1.2	-1.3	1.1	-2.0
Average weekly beer plus cider intake	1.2	1.7	3.3	1.8	-0.4	0.1	1.8
Irritability	0.6	1.1	3.5	1.9	0.3	-0.6	0.7
Risk taking	0.3	0.4	1.6	1.3	-0.1	0.2	-0.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.0	0.4	0.3	-1.0	-0.9
Fractured/broken bones in last 5 years	0.8	1.0	3.3	0.7	-0.5	1.8	0.3
Age started oral contraceptive pill	0.9	1.2	2.5	-1.5	-0.2	1.6	0.2
Diastolic blood pressure, automated reading	0.5	1.6	3.9	-0.1	-2.0	0.3	-1.6
Ever depressed for a whole week	0.6	0.7	1.6	-1.3	-0.6	0.8	-0.6
Unable to work because of sickness or disability	0.1	0.2	0.4	0.1	-0.6	-0.0	-0.6
Commuting to job workplace: Cycle	2.0	2.5	4.2	-2.0	-1.6	-0.3	-1.7
Myopia	1.3	1.9	3.6	-1.8	-0.5	0.6	-1.9
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.7	0.4	1.1	-1.3	0.2
Cholesterol lowering medication	0.2	0.2	0.4	-0.5	-0.6	-0.0	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	3.3	0.7	-1.8	1.8	-0.3
Pain experienced in last month	0.5	0.8	1.8	-1.3	0.4	-0.1	-1.1
Supplements: Calcium	2.0	2.2	3.9	-1.9	1.1	-0.1	-2.0
Basal cell carcinoma (self-reported)	1.2	1.5	3.8	-0.6	-1.9	1.2	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	-0.5	0.9	-0.3	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.5	-1.0	1.2	1.6	0.1
Heart disease (siblings)	1.2	1.5	2.8	1.7	-1.4	0.9	-0.6
Alcohol drinker status: Previous	1.1	1.2	2.7	-0.5	-0.8	1.6	1.2
Pack years of smoking	0.3	0.4	0.8	-0.8	0.9	-0.1	-0.3
Impedance of whole body	0.8	4.0	10.2	3.2	2.0	-0.3	1.3
Leg fat mass (left)	0.3	1.3	1.7	1.1	-1.0	1.3	1.1
Arm predicted mass (left)	1.8	9.0	22.1	1.9	-4.7	3.0	1.1