Hub : Genes

CPOX

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.2190 0.0570 1.6e-05 0.034 NA 0.017 NA 0.041 0.00140 NA 1.8e-02 NA 4.7e-04
2 METSIM Adipose 0.0864 0.0251 9.6e-07 0.019 0.049 0.045 0.048 0.039 0.00062 6.4e-08 2.2e-07 8.1e-08 1.4e-06
3 TCGA Colon Adenocarcinoma 0.1020 0.0480 1.9e-03 0.003 0.025 0.012 NA 0.023 0.21000 1.3e-02 6.6e-02 NA 1.6e-02
4 TCGA Prostate Adenocarcinoma 0.0650 0.0275 1.9e-04 0.034 0.039 0.011 NA 0.026 0.00016 5.9e-05 2.1e-02 NA 9.6e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.1 0.2 0.7 0.0 0.2 -0.1 -0.8
Bipolar Disorder or Schizophrenia 1.0 2.5 5.1 -0.5 1.8 -2.3 -1.1
Depressed Affect (Nagel 2018) 0.2 0.5 0.7 0.8 -0.1 -0.8 0.8
Depression (Nagel 2018) 0.8 1.1 3.7 0.8 -0.1 1.9 0.5
Intelligence (Savage-Jansen 2018) 0.9 2.8 7.1 -2.7 -0.4 0.2 -1.9
Neuroticism (Nagel 2018) 0.5 1.2 2.9 1.7 0.8 -0.2 1.0
Schizophrenia (2018) 1.6 3.4 7.8 -0.6 2.2 -2.8 -0.8
Schizophrenia vs Biploar Disorder 1.2 1.6 2.7 1.6 1.3 -0.3 1.4
Worry (Nagel 2018) 0.8 1.8 3.0 1.6 1.2 -0.3 1.7
Alzheimer’s Disease (in mother) 0.9 1.1 3.1 1.0 -1.8 0.2 -0.6
Alzheimer’s Disease (in father) 2.2 2.4 5.3 -0.4 -2.3 1.3 -1.5
Alzheimer’s Disease (including proxy) 1.7 2.5 6.6 0.8 -2.6 0.9 -1.3
Crohns Disease (2017) 0.2 0.5 1.3 -0.2 -0.8 1.2 -0.3
Irritable Bowel Disease (IBD) 1.2 2.8 5.9 -1.3 -1.7 0.9 -2.4
Ulcerative Colitis (UC) 1.9 3.6 8.8 -1.8 -1.6 -0.1 -3.0
Major Depression (MDD) 0.4 0.4 1.1 -1.1 0.5 -0.4 -0.4
Reaction Time 0.2 0.4 0.8 0.5 -0.5 -0.9 -0.4
Verbal and Numeric Reasoning (VNR) 0.5 1.3 3.3 -1.8 0.3 0.5 -1.2
Breast Cancer 1.0 2.4 7.0 0.4 2.6 -1.6 0.3
Ovarian Cancer 0.4 0.5 1.4 -0.5 1.2 0.1 -0.7
Prostate Cancer 1.5 2.1 3.8 1.0 -1.5 1.9 1.2
Age at First Birth 0.5 0.7 2.2 0.2 1.5 -0.6 0.3
Bipolar Disorder (2011) 1.0 0.9 3.1 -1.8 0.8 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.5 1.0 -0.8 0.7 -1.0 0.0
Coronary Artery Disease (CAD) 0.4 0.5 1.8 0.3 1.3 -0.4 -0.3
Crohns Disease (2012) 0.6 1.0 2.8 0.3 -1.7 1.0 -0.3
Mean Putamen Volume 0.3 0.4 0.7 0.8 0.4 0.3 0.6
Fasting Glucose 0.2 0.3 0.9 0.2 -0.0 1.0 -0.3
HbA1C 0.5 0.5 1.0 -0.8 0.4 1.0 0.6
HDL Cholesterol 1.2 2.0 5.9 2.4 0.7 -1.2 0.6
LDL Cholesterol 0.3 0.5 1.2 0.7 0.6 -1.1 0.2
Lupus 1.0 1.5 2.8 1.7 0.6 1.3 1.0
Neuroticism (2016) 0.3 0.5 1.5 -0.5 1.2 -0.5 -0.0
Primary Biliary Cirrhosis 2.6 3.7 5.4 -2.3 -1.3 1.9 -2.1
Rheumatoid Arthritis 0.4 0.5 1.6 0.2 1.2 0.1 -0.6
Schizophrenia (2014) 0.7 1.4 3.4 0.1 1.4 -1.8 -0.6
Triglycerides 1.4 2.2 4.1 -2.0 1.6 -1.3 0.8
Type 2 Diabetes (T2D) (2012) 2.2 2.6 7.7 -2.8 1.3 -1.0 -0.4
Ulcerative Colitis 2.2 3.2 8.9 -1.4 -1.2 -0.7 -3.0
Blood Eosinophil Count 0.7 5.7 8.9 2.8 3.0 -0.9 2.2
Blood Platelet Count 0.1 0.8 2.4 -0.1 -1.5 0.2 -0.9
Blood Red Count 0.2 2.1 5.3 -0.1 -1.2 2.3 -1.2
Blood White Count 0.6 4.4 13.6 -3.7 1.5 0.7 -1.1
Heel T-Score 0.1 0.9 2.0 -1.1 0.3 0.5 -1.4
BMI 0.2 1.4 4.6 -2.1 -0.6 0.5 -0.5
Height 1.5 28.1 63.7 5.6 -8.0 3.9 1.5
Waist Hip Ratio (WHR) 0.0 0.1 0.1 0.4 0.2 0.3 0.2
Systolic Blood Pressure 0.3 1.5 4.8 -2.2 0.9 0.2 -0.3
Smoking Status 0.5 1.3 2.1 1.4 0.9 0.6 1.4
Allergy or Eczema 0.3 0.8 1.7 -1.3 0.7 -0.8 -0.6
Cardiovascular Disease 0.3 1.0 3.0 -0.2 -0.8 1.7 0.4
Hypothyroidism (self reported) 0.7 1.5 1.7 1.3 1.3 -1.1 1.3
Respiratory disease 0.8 1.7 2.3 -1.2 1.3 -1.2 -1.5
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.6 -0.6 0.2 1.3 -0.1
Lung FEV1/FVC ratio 0.4 1.9 3.7 0.8 -1.9 1.8 -0.1
Lung FVC 1.0 5.2 8.2 -2.9 -1.2 2.6 -2.2
Neuroticism 0.2 0.4 0.8 0.9 0.6 -0.4 0.4
Chronotype (morning person) 0.2 0.5 1.6 -1.3 -0.5 0.4 -0.4
Hair Pigment 0.0 0.6 1.1 -0.7 1.0 0.8 0.1
Tanning 0.1 1.2 3.7 1.9 0.8 0.2 0.7
Hand grip strength (left) 0.6 1.7 2.9 1.3 -1.7 -0.5 -1.3
Number of treatments/medications taken 0.3 0.5 1.2 -1.1 0.6 0.3 -0.7
Average weekly spirits intake 0.1 0.1 0.2 -0.4 -0.2 -0.2 -0.0
Sensitivity / hurt feelings 1.2 2.1 7.3 2.7 0.5 0.4 0.9
Frequency of depressed mood in last 2 weeks 0.7 1.0 1.7 1.3 -0.4 0.8 1.1
Hearing difficulty/problems: Yes 0.6 1.0 3.2 0.7 -0.2 1.8 0.4
Relative age of first facial hair 0.5 1.1 2.1 -0.9 0.6 -1.1 -1.4
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.4 -0.4 -0.6 0.4 -0.1
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.4 1.0 -1.2 0.3 -0.4
Ever had hysterectomy (womb removed) 4.4 5.0 13.8 -2.2 -1.1 -0.2 -3.7
Systolic blood pressure, automated reading 0.2 0.7 1.9 -1.4 0.9 -0.3 0.0
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 2.0 -1.4 -0.2 -0.1 -0.6
Angina 0.6 0.8 1.6 0.2 1.3 -0.4 1.1
Medication for hormone replacement therapy 1.9 2.1 7.5 2.7 -0.8 -0.0 -0.6
Vitamin and mineral supplements 0.3 0.5 1.3 0.4 -0.4 -1.2 -0.4
Supplements: Zinc 0.8 0.8 1.5 -0.9 0.3 1.2 -1.0
Medication: Co-codamol 1.7 2.0 6.2 0.6 -1.2 2.5 -0.1
Medication: Metformin 1.7 2.4 6.7 0.7 -1.6 2.6 -0.1
Diabetes (father) 0.5 0.6 1.6 1.3 0.8 -0.2 0.1
Diabetes (mother) 0.6 0.8 1.3 1.2 -1.0 -0.9 -0.2
Severe depression (siblings) 0.6 0.6 1.3 -0.1 0.6 -1.1 1.0
Pack years adult smoking proportion 0.3 0.4 0.9 -0.9 0.9 0.1 0.1
Impedance of leg (right) 1.6 7.6 18.1 4.2 2.1 -0.6 2.7
Leg fat-free mass (left) 1.3 6.9 17.7 -0.2 -4.2 3.1 -0.1
Trunk fat percentage 0.3 1.1 2.8 1.1 -0.3 1.7 0.5
Hand grip strength (right) 1.1 3.0 7.0 1.1 -2.6 -0.5 -1.9
Townsend deprivation index at recruitment 0.2 0.3 1.0 0.4 -1.0 -0.2 -0.5
Current tobacco smoking 1.0 1.6 4.1 0.6 2.0 0.1 1.4
Average weekly fortified wine intake 1.0 1.2 1.5 -1.2 1.2 -1.2 -0.6
Maternal smoking around birth 2.1 3.1 10.0 0.7 1.3 -3.2 0.1
Fed-up feelings 0.9 1.7 4.1 1.2 0.9 -2.0 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 0.9 0.9 -0.6 1.0 0.2
Relative age voice broke 0.6 1.0 2.1 -0.4 -1.0 -1.4 -0.8
Taking other prescription medications 0.3 0.5 0.9 -0.9 0.9 0.3 0.1
Age when periods started (menarche) 0.7 1.7 5.0 0.3 1.3 -2.2 0.0
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 4.7 -0.8 0.9 0.2 -2.2
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 2.9 -1.7 1.0 -0.8 -0.5
Tinnitus: Yes, but not now, but have in the past 1.2 1.2 3.4 1.1 -0.3 0.6 1.8
Qualifications: CSEs or equivalent 0.2 0.3 0.4 0.6 0.1 0.6 0.5
Serious illness, injury or assault to yourself 0.6 0.8 1.7 0.3 1.3 -0.0 1.2
High blood pressure 0.3 0.9 1.8 -0.3 -1.3 1.3 -0.5
Hayfever, allergic rhinitis or eczema 0.8 1.8 3.2 -1.8 1.4 -1.2 -0.7
Multivitamins +/- minerals 0.2 0.2 0.5 -0.7 0.2 0.6 -0.3
Stomach or abdominal pain in last month 1.5 1.8 3.0 1.7 0.8 -0.9 1.7
Supplements: Glucosamine 0.1 0.1 0.4 -0.6 -0.0 0.1 -0.1
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.8 0.8 -0.7 0.9 0.5
Medication: Atenolol 0.6 0.8 2.0 -1.4 0.9 -0.5 0.0
Medication: Levothyroxine sodium 0.8 1.4 4.2 1.2 0.3 -0.2 2.0
Sitting height 2.2 15.8 27.7 5.3 -4.5 3.2 2.3
Chronic bronchitis/emphysema (father) 1.1 1.3 4.0 2.0 -0.6 -0.0 0.9
High blood pressure (mother) 0.8 1.1 3.1 -0.8 0.8 0.0 1.8
Body mass index (BMI) 0.1 0.6 1.0 -1.0 -0.8 0.8 0.1
Impedance of leg (left) 1.6 7.7 19.9 4.5 1.9 -0.6 2.7
Leg predicted mass (left) 1.3 6.9 17.9 -0.2 -4.2 3.1 -0.1
Trunk fat mass 0.5 2.1 4.5 1.3 -1.4 2.1 0.5
Waist circumference 0.3 1.1 2.5 -0.3 -1.6 1.4 -0.2
Number of incorrect matches in round 0.7 1.2 2.5 -0.7 -0.9 -1.1 -1.6
Past tobacco smoking 0.3 0.6 1.5 -1.2 -0.3 0.8 -0.5
Alcohol usually taken with meals 1.6 2.6 6.0 -0.5 -2.0 0.4 -2.5
Nervous feelings 1.4 2.5 5.7 0.1 2.4 -1.4 1.6
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 2.3 1.5 0.3 -0.3 0.6
Hearing difficulty/problems with background noise 2.3 3.7 5.7 2.2 -0.2 2.4 2.1
Hair/balding pattern: Pattern 2 0.3 0.4 0.7 0.3 -0.9 -0.6 -0.7
Had menopause 0.8 1.0 2.4 1.3 0.3 1.5 0.3
Had other major operations 0.8 1.0 1.7 -0.8 -1.3 -0.4 -1.3
Forced vital capacity (FVC) 1.4 5.3 15.8 -0.4 -4.0 1.8 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 2.0 -1.4 0.6 -1.3 -0.9
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.6 -0.8 -0.4 1.3 0.6
Qualifications: None of the above 0.1 0.2 0.6 -0.7 0.1 0.4 0.2
Financial difficulties in last 2 years 0.2 0.2 0.5 -0.0 -0.7 0.1 -0.7
Mouth/teeth dental problems 0.9 1.4 3.3 0.7 -1.3 1.8 0.4
Heart attack 0.3 0.3 0.8 -0.3 0.9 -0.6 0.1
Allergy 1.1 2.6 5.6 1.4 -2.4 1.6 0.1
Pain all over the body in last month 1.6 1.8 5.6 -0.4 -2.4 1.1 0.2
Diabetes (self-reported) 1.1 1.6 5.4 -0.8 -0.2 2.3 -0.6
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.5 -0.5 0.2 0.3 0.7
Medication: Ramipril 0.3 0.4 0.6 -0.8 -0.6 -0.4 -0.7
Medication: Simvastatin 0.2 0.3 0.3 -0.5 0.5 0.4 -0.6
Fluid intelligence score 0.4 0.8 1.9 -1.4 1.0 0.6 -0.3
Illnesses of siblings 0.1 0.2 0.4 0.5 -0.1 0.7 0.3
Neuroticism score 1.0 2.1 3.8 1.9 1.2 -0.2 1.7
Weight 0.9 4.6 11.6 0.8 -3.4 2.5 0.4
Impedance of arm (right) 0.2 0.8 2.5 0.8 1.6 -0.1 -0.1
Arm fat percentage (right) 0.1 0.4 1.0 -1.0 -0.1 0.6 -0.3
Trunk fat-free mass 1.6 9.5 27.8 1.1 -5.3 3.0 0.2
Hip circumference 0.3 1.1 3.7 -0.3 -1.9 0.8 -0.1
Time employed in main current job 0.3 0.3 0.7 -0.7 -0.4 -0.1 -0.8
Alcohol intake versus 10 years previously 0.7 1.0 1.8 1.1 -1.4 0.2 1.1
Father’s age at death 2.7 3.6 7.2 -2.7 -0.2 -0.6 -2.6
Worrier / anxious feelings 1.6 3.1 9.2 3.0 -0.7 1.3 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.6 0.1 0.3 0.8 0.1
Falls in the last year 0.1 0.2 0.5 -0.3 0.0 -0.1 -0.7
Hair/balding pattern: Pattern 3 0.1 0.2 0.2 0.3 -0.5 0.5 -0.2
Number of live births 0.4 0.5 0.7 -0.9 0.6 0.5 -0.8
Forced expiratory volume in 1-second (FEV1) 1.7 5.8 17.0 -0.4 -4.1 2.0 -1.4
Pulse rate 0.9 1.5 2.4 1.3 -1.6 1.4 0.0
Happiness 0.4 0.5 1.7 -1.3 0.4 -0.4 -0.1
Noisy workplace 0.4 0.4 0.7 -0.7 -0.8 0.0 -0.8
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.7 -1.3 0.3 0.4 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 1.0 0.6 0.1 -0.3 -1.0
Mouth/teeth dental problems: Dentures 0.9 1.6 3.1 -1.2 1.8 -1.3 -0.2
Asthma 0.8 1.7 2.7 -1.3 1.6 -1.5 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.3 0.6 0.4 0.1 0.5
Medication: Cholesterol lowering 0.6 0.9 3.1 0.4 0.7 1.8 0.1
Depression (self-reported) 1.5 1.8 2.8 -1.0 1.7 -1.0 -1.6
Medication: Lansoprazole 1.8 2.1 4.4 -0.6 2.1 -0.7 1.7
Prospective memory result 0.6 0.7 2.2 0.3 -1.5 0.6 -0.1
Lung cancer (father) 0.2 0.2 0.5 -0.5 -0.7 0.3 -0.0
Illnesses of mother 0.5 0.6 1.0 0.2 1.0 0.9 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 1.9 6.2 17.2 -1.1 -4.2 1.6 -2.0
Pulse wave Arterial Stiffness index 0.3 0.4 1.1 0.7 0.1 -1.0 0.1
Impedance of arm (left) 0.2 0.9 2.6 1.0 1.6 0.1 -0.2
Arm fat mass (right) 0.4 1.5 3.8 -0.1 -1.9 1.5 -0.1
Trunk predicted mass 1.7 9.8 28.1 1.2 -5.3 3.1 0.3
Standing height 1.8 18.0 36.5 4.1 -6.0 4.2 0.9
Length of working week for main job 0.4 0.5 0.9 1.0 0.0 0.3 0.9
Exposure to tobacco smoke at home 1.6 1.8 2.8 1.2 1.7 -1.1 1.3
Breastfed as a baby 1.4 1.8 3.0 -1.7 1.0 -0.6 -1.6
Tense / ‘highly strung’ 1.4 2.3 5.3 2.3 1.1 -0.3 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.7 0.1 0.2 -0.6 -0.9
Hair/balding pattern: Pattern 4 1.0 2.5 6.1 0.4 1.9 0.2 2.5
Birth weight of first child 2.8 5.1 12.2 -1.9 -2.1 0.2 -3.5
Peak expiratory flow (PEF) 2.0 4.7 13.6 0.1 -3.7 1.9 -1.3
Pulse wave reflection index 0.8 1.0 2.5 0.7 -0.7 -1.6 -0.7
Ever highly irritable/argumentative for 2 days 0.6 0.8 2.7 0.5 0.4 0.0 1.6
Loud music exposure frequency 0.3 0.3 0.4 -0.6 0.5 -0.6 -0.6
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.3 -0.2 1.2 0.1 0.4
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 1.7 1.2 1.3 -0.9 0.9
Blood clot in the leg (DVT) 1.1 1.4 2.6 -1.1 1.3 1.6 -0.0
Medication: Paracetamol 0.4 0.7 1.4 0.9 0.1 -1.2 0.8
Headache pain in last month 0.7 1.2 2.4 0.2 1.4 -1.6 -0.8
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.3 -0.8 -1.1 -0.6 -0.4
Glaucoma (self-reported) 0.4 0.5 1.4 -0.4 -1.2 -0.5 -0.2
Gout (self-reported) 1.0 1.4 2.5 1.0 1.3 -0.8 1.6
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 6.2 1.8 1.1 -0.5 2.5
Medication: Amlodipine 0.7 1.0 3.9 0.4 0.1 2.0 -0.2
Medication: Ventolin 100micrograms inhaler 3.1 4.0 6.5 -2.5 1.4 -2.4 -1.2
Birth weight 0.2 0.4 0.7 -0.7 0.8 -0.2 0.7
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.2 0.3 0.1 -1.5 0.1
High blood pressure (siblings) 0.1 0.2 0.4 -0.3 0.6 0.2 0.6
Forced vital capacity (FVC), Best measure 1.6 5.9 16.4 -0.9 -4.0 1.6 -1.9
Body fat percentage 0.2 0.7 1.7 0.8 -0.2 1.3 0.5
Leg fat percentage (right) 0.3 1.0 2.1 1.4 0.5 0.5 1.2
Arm fat-free mass (right) 1.7 8.5 21.4 1.6 -4.6 3.0 0.8
Exposure to tobacco smoke outside home 0.0 0.0 0.1 0.1 0.3 0.1 0.3
Comparative body size at age 10 0.7 2.0 6.4 -2.5 1.2 -0.1 -0.4
Number of full brothers 0.4 0.5 1.7 1.3 0.2 -0.6 -0.2
Worry too long after embarrassment 1.5 2.4 6.8 2.6 -0.4 1.3 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.0 -1.3 1.4 -0.4 -1.1
Wheeze or whistling in the chest in last year 0.4 0.8 2.5 -0.5 1.6 -0.0 -0.7
Number of children fathered 0.9 1.0 2.2 1.5 0.4 0.1 1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.6 1.3 -0.2 0.1 -0.8
Age at first live birth 0.1 0.2 0.7 -0.4 -0.8 -0.3 -0.1
Pulse wave peak to peak time 0.5 0.6 2.0 -0.4 -0.5 1.4 -0.1
Health satisfaction 0.6 0.8 1.9 -0.6 0.9 0.2 1.4
Shortness of breath walking on level ground 0.7 0.8 2.1 0.0 1.1 -0.0 1.4
Qualifications: College or University degree 1.0 3.1 7.4 -0.1 -1.4 1.8 -2.7
Eye problems/disorders: None of the above 0.3 0.3 0.7 0.8 0.1 -0.7 -0.4
Mouth/teeth dental problems: Loose teeth 1.8 2.2 4.1 0.4 2.0 -2.0 0.6
Emphysema/chronic bronchitis 2.0 2.3 4.6 0.3 2.1 -1.6 -1.4
Medication for pain relief, constipation, heartburn 0.3 0.5 1.5 -0.6 -0.3 1.2 -0.1
Neck or shoulder pain in last month 1.0 1.5 1.9 1.2 -1.3 0.9 1.4
Medication: Blood pressure 0.1 0.2 0.6 -0.0 0.3 0.0 -0.8
Angina (self-reported) 0.7 0.9 2.1 -0.1 1.4 -0.4 1.2
Migraine (self-reported) 1.7 2.1 6.6 -2.6 0.6 -0.9 -0.8
Medication: Ibuprofen 0.1 0.1 0.3 0.5 0.2 0.2 0.2
Medication: Allopurinol 0.4 0.5 1.0 0.6 1.0 -0.5 0.7
Medication: Omeprazole 1.4 1.7 3.8 0.8 -1.5 2.0 -0.1
Medication: Seretide 50 evohaler 0.7 0.8 2.6 -0.1 -0.4 0.6 -1.6
Mean time to correctly identify matches 0.1 0.1 0.2 0.4 0.3 -0.4 0.1
Heart disease (mother) 0.2 0.3 0.5 -0.4 -0.5 0.5 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 4.0 -0.7 0.7 -2.0 0.3
Whole body fat mass 0.4 1.7 3.3 0.8 -1.6 1.8 0.4
Leg fat mass (right) 0.3 1.1 1.4 1.0 -0.9 1.2 1.1
Arm predicted mass (right) 1.7 8.8 22.7 1.7 -4.8 3.0 0.6
Pulse rate, automated reading 1.0 3.4 4.7 2.1 -2.1 2.2 0.1
Alcohol intake frequency. 0.5 1.2 1.9 -0.5 -1.4 1.0 1.3
Comparative height size at age 10 3.2 17.7 29.9 4.4 -5.5 4.6 0.3
Number of full sisters 0.5 0.6 1.2 -0.2 -0.1 -1.0 -1.1
Suffer from ‘nerves’ 0.3 0.5 0.7 0.8 0.7 -0.4 0.9
Overall health rating 0.8 1.7 2.0 -1.3 1.1 1.3 1.4
Chest pain or discomfort 0.9 1.3 2.8 1.1 0.4 1.7 1.1
Had major operations 1.0 1.2 3.5 0.9 -1.9 0.2 -0.7
Age at last live birth 0.5 0.7 1.9 -0.8 0.4 -1.4 -0.6
Family relationship satisfaction 1.9 2.4 3.8 -2.0 1.7 -1.7 -0.2
Leg pain on walking 0.8 1.0 2.8 1.7 0.2 0.2 1.1
Qualifications: NVQ or HND or HNC or equivalent 1.6 2.0 4.1 1.4 -2.0 0.8 1.1
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.2 -1.1 0.7 0.4 0.5
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 2.2 -0.1 -0.3 1.5 -0.7
Medication: Aspirin 0.2 0.2 0.6 -0.1 -0.5 -0.0 -0.8
Supplements: Vitamin C 1.2 1.4 3.1 -0.5 1.8 0.1 1.4
Knee pain experienced in last month 0.2 0.3 0.7 0.9 -0.4 -0.2 -0.3
Hypertension (Self-reported) 0.3 0.9 2.2 -0.4 -1.0 1.5 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.4 0.6 -0.4 -0.6 -0.7
Illnesses of father: Heart disease 0.6 0.8 1.7 -0.7 0.5 0.8 -1.3
Illnesses of siblings: Diabetes 0.2 0.3 0.6 0.2 0.0 -0.8 -0.8
Smoking status: Previous 0.2 0.3 0.8 0.6 -0.1 -0.9 0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.6 6.9 2.6 -2.3 1.1 1.0
Whole body fat-free mass 1.6 9.0 24.8 0.8 -5.0 3.2 0.3
Leg fat-free mass (right) 1.3 7.0 18.6 -0.4 -4.3 3.0 -0.2
Arm fat percentage (left) 0.1 0.4 1.0 -1.0 -0.1 0.6 -0.5
Average weekly red wine intake 0.6 0.8 1.9 -1.4 -0.2 0.7 -0.9
Handedness (chirality/laterality): Left-handed 1.8 2.2 4.0 0.9 1.9 -0.3 2.0
Mood swings 1.2 2.2 4.9 1.1 1.2 -1.0 2.2
Loneliness, isolation 0.1 0.2 0.5 0.7 -0.2 0.5 -0.1
Long-standing illness, disability or infirmity 0.5 0.7 1.4 0.6 0.0 1.1 1.2
Ever had bowel cancer screening 0.8 1.0 1.7 1.3 -1.0 1.1 -0.1
Diabetes diagnosed by doctor 0.7 1.2 4.7 0.1 -0.1 2.2 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.6 -0.5 -0.2 -0.8 -0.2
Friendships satisfaction 0.1 0.2 0.4 -0.3 -0.4 0.3 -0.6
Qualifications: nursing, teaching 1.3 2.0 3.2 -1.8 1.7 -1.3 -0.2
Commuting to job workplace: Walk 2.2 2.4 7.8 -0.9 2.8 -1.0 0.1
Eye problems/disorders: Cataract 0.2 0.2 0.5 0.2 -0.4 0.7 0.2
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.3 -0.7 0.6 -1.5 -0.4
Medication for cholesterol 1.1 1.6 3.1 -1.0 1.2 -1.8 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.4 4.0 7.1 2.7 -2.3 1.6 0.7
Back pain experienced in last month 0.9 1.3 2.6 1.5 -0.6 1.6 0.1
Mineral and other dietary supplements 0.3 0.4 1.4 0.3 -1.2 0.3 -0.3
Breast cancer (self-reported) 1.3 1.6 5.9 0.4 0.0 2.4 0.6
Asthma (self-reported) 0.7 1.5 2.4 -1.2 1.6 -1.4 -0.1
Osteoporosis (self-reported) 1.7 2.1 6.1 -0.4 1.4 0.5 2.5
Osteoarthritis (self-reported) 1.2 1.6 4.7 -1.1 -2.2 0.5 -0.4
Medication: Aspirin 0.1 0.2 0.7 0.2 0.1 -0.0 -0.9
Medication: Gliclazide 1.0 1.1 3.9 0.6 -0.5 2.0 0.1
Illnesses of father: None of the above (group 1) 1.5 1.9 3.6 -1.9 -0.3 -1.6 -1.2
Smoking status: Current 1.2 1.9 3.8 0.8 2.0 0.3 1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.5 -0.7 -0.3 0.6 -0.2
Whole body water mass 1.5 8.7 24.7 0.7 -5.0 3.1 0.1
Leg predicted mass (right) 1.3 6.9 17.9 -0.4 -4.2 3.1 -0.2
Arm fat mass (left) 0.3 1.2 2.9 -0.0 -1.7 1.4 -0.0
Number of self-reported non-cancer illnesses 0.5 0.9 2.4 -1.6 0.9 -0.5 -0.2
Average weekly champagne plus white wine intake 1.3 1.8 3.9 -1.7 -0.5 -0.4 -2.0
Miserableness 0.9 1.6 3.4 1.8 0.4 -0.3 1.7
Guilty feelings 0.2 0.3 0.5 0.7 0.5 -0.5 -0.1
Wears glasses or contact lenses 0.9 1.0 2.1 -1.3 0.4 0.4 -1.5
Ever taken oral contraceptive pill 0.5 0.6 1.6 -0.4 0.7 -0.2 1.3
Hearing aid user 2.3 2.6 6.9 -1.8 2.6 -0.1 0.7
Mother’s age at death 0.4 0.5 1.1 -0.2 -0.6 1.1 -0.8
Financial situation satisfaction 0.7 0.9 1.4 -1.2 0.8 -1.2 0.4
Tinnitus: Yes, now most or all of the time 1.1 1.3 2.1 -0.1 -1.5 1.4 -1.1
Commuting to job workplace: Public transport 1.1 1.3 2.2 1.5 -1.4 0.7 -0.8
Eye problems/disorders: Glaucoma 0.3 0.3 0.5 -0.7 0.1 -0.7 0.5
Medication: Blood pressure 0.8 1.6 3.0 -1.1 -1.4 1.7 0.5
Pain type(s) experienced in last month: Hip pain 2.0 2.6 7.4 -0.3 1.0 1.4 2.7
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.5 0.5 0.5 0.2 0.7
High cholesterol (Self-reported) 0.1 0.2 0.5 0.6 0.0 0.2 -0.7
Medication: Bendroflumethiazide 0.3 0.5 1.0 -1.0 0.4 -0.6 -0.6
Medication: Paracetamol 0.3 0.5 0.9 0.6 -0.0 -1.0 0.8
Medication: Lisinopril 0.2 0.3 0.7 -0.6 -0.1 0.8 -0.3
Medication: Atorvastatin 0.6 0.7 1.8 -0.8 -0.7 1.3 -0.1
Illnesses of father: High blood pressure 1.3 1.6 3.9 0.8 1.3 0.3 2.0
Alcohol drinker status: Never 1.8 2.2 4.5 -1.9 2.1 -0.6 0.2
Ever smoked 0.4 0.6 1.5 0.6 0.6 -1.2 -0.5
Basal metabolic rate 1.5 8.1 22.8 0.8 -4.8 3.0 0.3
Leg fat percentage (left) 0.3 1.2 2.5 1.6 0.3 0.7 1.2
Arm fat-free mass (left) 1.8 9.2 22.5 2.0 -4.7 3.1 1.0
Number of operations (self-reported) 1.4 2.0 3.8 -1.2 -1.3 1.1 -2.0
Average weekly beer plus cider intake 1.2 1.7 3.3 1.8 -0.4 0.1 1.8
Irritability 0.6 1.1 3.5 1.9 0.3 -0.6 0.7
Risk taking 0.3 0.4 1.6 1.3 -0.1 0.2 -0.1
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.0 0.4 0.3 -1.0 -0.9
Fractured/broken bones in last 5 years 0.8 1.0 3.3 0.7 -0.5 1.8 0.3
Age started oral contraceptive pill 0.9 1.2 2.5 -1.5 -0.2 1.6 0.2
Diastolic blood pressure, automated reading 0.5 1.6 3.9 -0.1 -2.0 0.3 -1.6
Ever depressed for a whole week 0.6 0.7 1.6 -1.3 -0.6 0.8 -0.6
Unable to work because of sickness or disability 0.1 0.2 0.4 0.1 -0.6 -0.0 -0.6
Commuting to job workplace: Cycle 2.0 2.5 4.2 -2.0 -1.6 -0.3 -1.7
Myopia 1.3 1.9 3.6 -1.8 -0.5 0.6 -1.9
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.7 0.4 1.1 -1.3 0.2
Cholesterol lowering medication 0.2 0.2 0.4 -0.5 -0.6 -0.0 -0.5
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 3.3 0.7 -1.8 1.8 -0.3
Pain experienced in last month 0.5 0.8 1.8 -1.3 0.4 -0.1 -1.1
Supplements: Calcium 2.0 2.2 3.9 -1.9 1.1 -0.1 -2.0
Basal cell carcinoma (self-reported) 1.2 1.5 3.8 -0.6 -1.9 1.2 -0.6
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.7 -0.5 0.9 -0.3 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 2.5 -1.0 1.2 1.6 0.1
Heart disease (siblings) 1.2 1.5 2.8 1.7 -1.4 0.9 -0.6
Alcohol drinker status: Previous 1.1 1.2 2.7 -0.5 -0.8 1.6 1.2
Pack years of smoking 0.3 0.4 0.8 -0.8 0.9 -0.1 -0.3
Impedance of whole body 0.8 4.0 10.2 3.2 2.0 -0.3 1.3
Leg fat mass (left) 0.3 1.3 1.7 1.1 -1.0 1.3 1.1
Arm predicted mass (left) 1.8 9.0 22.1 1.9 -4.7 3.0 1.1