TWAS hub - COL8A1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1880	0.0490	8.2e-08	0.009	NA	0.036	NA	0.048	0.06800	NA	0.00095	NA	0.00017
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0913	0.0423	4.6e-03	0.005	0.008	0.033	NA	0.023	0.09000	0.038	0.00012	NA	0.00120
3	TCGA	Brain Lower Grade Glioma	0.0316	0.0183	5.9e-03	0.028	0.008	0.014	NA	0.013	0.00033	0.033	0.00920	NA	0.01100

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Ovarian Cancer	6.0	7.9	11.7	-3.1	-1.5	3.4
Breast Cancer	4.3	10.4	27.9	0.4	-1.7	5.3
Supplements: Zinc	2.9	3.1	5.5	1.4	-1.4	-2.3
Lupus	2.8	4.2	7.0	-2.6	-0.6	2.3
Hair/balding pattern: Pattern 2	2.8	3.6	8.9	0.3	3.0	-1.3
Fractured/broken bones in last 5 years	2.5	3.3	6.5	2.6	-1.7	0.5
Diabetes (mother)	2.3	2.9	4.3	-2.0	0.8	-2.1
Number of self-reported non-cancer illnesses	2.3	4.1	11.7	-0.3	0.6	3.4
Alzheimer’s Disease (in father)	2.2	2.4	6.2	0.8	0.5	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.4	3.4	0.5	-1.8	-1.8
Mouth/teeth dental problems	2.1	3.2	9.6	-0.0	0.2	-3.1
Pulse wave reflection index	2.1	2.5	7.6	-0.1	-2.8	0.2
Loud music exposure frequency	2.1	2.3	5.8	0.3	1.0	2.4
Medication: Ibuprofen	2.1	2.5	6.7	-1.0	0.1	-2.6
Breast cancer (self-reported)	2.1	2.5	6.7	-0.5	-0.7	-2.6
Waist Hip Ratio (WHR)	2.0	9.1	17.8	-2.7	4.2	-1.5
Height	1.9	36.4	70.9	-8.4	5.2	3.3
Alcohol intake versus 10 years previously	1.9	2.9	7.7	-0.9	2.8	0.0
Standing height	1.9	18.9	40.1	-6.3	3.4	2.3
Maternal smoking around birth	1.8	2.6	5.8	-0.2	2.4	1.4
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	3.4	-1.3	0.7	1.8
Number of full brothers	1.8	2.3	6.2	-0.8	-2.5	-0.2
Arm predicted mass (right)	1.8	9.0	15.7	-4.0	2.6	2.1
Ever had prostate specific antigen (PSA) test	1.8	2.0	4.5	0.9	-0.9	-2.1
Cholesterol lowering medication	1.8	2.7	5.8	-0.7	1.3	2.4
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	5.9	-0.7	0.0	-2.4
Medication: Cholesterol lowering	1.7	2.7	4.4	0.7	-1.8	2.1
Medication: Atorvastatin	1.7	2.2	3.1	1.8	-0.7	1.7
Arm predicted mass (left)	1.7	8.4	15.6	-4.0	2.5	1.8
Lung FVC	1.6	8.3	14.9	2.4	-3.9	-2.0
Waist circumference	1.6	5.8	9.3	-2.0	2.0	-3.1
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	2.4	-1.5	1.6	1.2
Arm fat-free mass (right)	1.6	8.3	14.1	-3.8	2.3	2.3
Comparative height size at age 10	1.6	8.9	22.3	-4.7	2.0	0.5
Depression (Nagel 2018)	1.5	2.3	5.7	-0.2	1.1	-2.4
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	2.7	-1.1	1.3	1.7
Impedance of leg (left)	1.5	7.1	17.6	-4.2	1.5	-1.1
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	3.1	1.4	-0.8	1.8
Chronic bronchitis/emphysema (mother)	1.5	1.7	2.2	-1.5	1.5	0.9
Leg pain on walking	1.5	1.9	4.2	-1.1	0.5	2.0
Handedness (chirality/laterality): Left-handed	1.5	1.8	2.0	1.3	1.3	1.4
Vascular/heart problems diagnosed by doctor	1.5	4.0	7.2	-2.7	1.4	-1.7
Number of live births	1.4	2.0	2.4	1.5	-1.4	1.3
Pulse rate	1.4	2.4	2.8	-1.7	1.6	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	4.0	-1.9	2.0	1.1
Hearing aid user	1.4	1.5	4.4	-0.4	0.3	-2.1
Illnesses of father: High blood pressure	1.4	1.7	4.4	-0.8	0.0	2.1
Arm fat-free mass (left)	1.4	6.9	13.0	-3.6	2.2	1.7
Myopia	1.4	2.1	2.9	1.3	-1.3	-1.7
Neuroticism (2016)	1.3	1.9	4.4	-1.2	2.1	-0.0
Primary Biliary Cirrhosis	1.3	1.9	5.0	0.1	-2.2	-0.8
Hypothyroidism (self reported)	1.3	2.9	7.1	0.3	-1.2	2.7
Vitamin and mineral supplements	1.3	1.8	2.6	-1.6	-1.5	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.3	0.8	1.1	-1.8
Sitting height	1.3	9.5	17.4	-4.2	2.2	2.5
Trunk fat-free mass	1.3	7.3	11.7	-3.4	1.8	2.7
Mouth/teeth dental problems: Dentures	1.3	2.2	4.7	-1.0	0.9	2.2
Trunk predicted mass	1.3	7.6	12.3	-3.5	1.8	2.7
Number of children fathered	1.3	1.5	2.7	1.6	-0.5	-1.2
Number of full sisters	1.3	1.6	3.1	1.3	-0.3	1.8
Commuting to job workplace: Walk	1.3	1.4	2.2	-1.1	-1.5	-0.8
Medication: Bendroflumethiazide	1.3	2.0	5.4	2.3	-0.8	0.4
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.2	-0.3	-1.8	1.0
Impedance of leg (right)	1.2	6.0	15.6	-4.0	1.3	-0.8
Trunk fat percentage	1.2	4.8	8.1	-2.8	0.9	-2.3
Average weekly fortified wine intake	1.2	1.4	3.6	-1.9	-0.1	0.8
Trunk fat mass	1.2	5.3	11.8	-3.4	1.4	-1.4
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	4.0	-2.0	1.3	-0.0
Peak expiratory flow (PEF)	1.2	2.8	6.5	-1.4	-2.6	-0.1
Wears glasses or contact lenses	1.2	1.4	2.5	1.2	-0.5	-1.6
Commuting to job workplace: Public transport	1.2	1.4	3.9	-0.4	0.4	2.0
Leg fat percentage (left)	1.2	4.3	6.0	-2.4	1.4	-2.2
HbA1C	1.1	1.3	3.5	-1.9	0.3	0.4
Medication: Co-codamol	1.1	1.2	1.8	0.9	-1.4	-1.1
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.8	-1.7	-1.0	0.5
High blood pressure	1.1	3.1	6.7	2.6	-1.0	1.3
Stomach or abdominal pain in last month	1.1	1.4	3.3	-0.8	1.8	-0.3
Pain all over the body in last month	1.1	1.2	1.8	-1.1	1.3	-0.7
Happiness	1.1	1.4	3.8	-1.9	0.3	0.6
Breastfed as a baby	1.1	1.4	3.6	-0.4	-1.9	0.6
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	4.0	-0.3	-1.5	2.0
Body fat percentage	1.1	4.2	6.6	-2.6	0.7	-2.4
Chest pain or discomfort	1.1	1.5	3.5	1.9	-0.8	0.7
Hypertension (Self-reported)	1.1	3.0	7.0	2.6	-0.5	1.3
Medication for cholesterol	1.1	1.7	2.5	-0.6	-1.6	-1.6
Osteoarthritis (self-reported)	1.1	1.4	3.4	-0.8	0.4	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	6.6	-0.0	-2.6	-0.5
Diastolic blood pressure, automated reading	1.1	3.4	8.5	1.3	0.2	-2.9
Alzheimer’s Disease (in mother)	1.0	1.2	1.9	-1.3	1.4	-0.1
Ulcerative Colitis (UC)	1.0	1.9	4.4	0.1	1.1	-2.1
Coronary Artery Disease (CAD)	1.0	1.2	2.6	-0.1	-1.6	-1.0
Falls in the last year	1.0	1.3	2.1	1.4	-1.3	-0.2
Hair/balding pattern: Pattern 3	1.0	1.6	3.1	0.3	-1.8	1.2
Exposure to tobacco smoke at home	1.0	1.2	2.2	1.5	-1.0	-0.4
Hair/balding pattern: Pattern 4	1.0	2.5	3.8	-0.7	-1.8	1.9
High blood pressure (siblings)	1.0	1.4	3.1	0.5	-1.8	1.0
Leg fat percentage (right)	1.0	3.5	5.6	-2.4	1.1	-1.9
Eye problems/disorders: None of the above	1.0	1.2	3.5	1.9	-0.4	-0.1
Migraine (self-reported)	1.0	1.2	2.2	1.1	1.5	0.4
Heart disease (mother)	1.0	1.3	2.1	0.8	-1.4	1.0
Whole body fat mass	1.0	4.3	9.9	-3.1	1.2	-1.3
Whole body fat-free mass	1.0	5.8	9.5	-3.1	1.7	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.6	-1.0	1.6	0.2
Medication: Gliclazide	1.0	1.1	2.7	1.6	-0.7	0.5
Whole body water mass	1.0	5.6	9.6	-3.1	1.6	2.2
Mother’s age at death	1.0	1.2	1.5	0.9	-1.2	-1.2
Basal metabolic rate	1.0	5.6	10.8	-3.3	1.7	1.8
Commuting to job workplace: Cycle	1.0	1.2	2.7	-0.9	-1.6	0.5
Supplements: Calcium	1.0	1.1	2.7	1.6	-0.6	-0.6
Leg fat mass (left)	1.0	3.8	8.5	-2.9	1.5	-0.8
Systolic Blood Pressure	0.9	4.6	11.4	3.4	-0.4	1.5
Systolic blood pressure, automated reading	0.9	2.5	6.8	2.6	-0.9	0.0
Relative age voice broke	0.9	1.4	2.3	-1.5	0.3	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.6	1.9	-1.0	-1.2
Medication: Atenolol	0.9	1.2	2.2	1.5	-1.1	0.2
Medication: Levothyroxine sodium	0.9	1.5	4.1	0.4	-0.4	2.0
Number of incorrect matches in round	0.9	1.5	4.0	-0.2	-0.6	2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	4.0	2.0	-1.0	-1.2
Medication: Ramipril	0.9	1.1	3.2	1.8	0.1	-0.1
Illnesses of siblings	0.9	1.2	2.8	-0.3	0.8	-1.7
Weight	0.9	4.2	9.5	-3.1	1.7	-0.1
Medication: Lansoprazole	0.9	1.1	1.6	-1.2	1.3	0.3
Tense / ‘highly strung’	0.9	1.5	1.7	-1.2	1.3	1.1
Medication: Amlodipine	0.9	1.3	1.9	1.4	-1.4	0.2
Supplements: Vitamin C	0.9	1.1	2.4	1.6	0.9	0.5
Medication: Paracetamol	0.9	1.4	3.2	-1.8	1.0	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.2	-1.0	1.5	0.5
Triglycerides	0.8	1.3	2.7	0.3	-1.0	1.6
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.6	-1.6	0.6	0.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.6	0.3	-1.3	0.9
Angina	0.8	1.0	1.9	0.3	-1.4	1.0
Qualifications: CSEs or equivalent	0.8	1.0	1.4	0.3	1.2	-1.2
Financial difficulties in last 2 years	0.8	1.0	2.6	1.6	-0.0	-0.7
Birth weight of first child	0.8	1.5	2.3	1.5	1.1	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.4	-0.8	1.2	-0.8
Health satisfaction	0.8	1.0	2.5	-0.7	1.6	-0.1
Neck or shoulder pain in last month	0.8	1.1	1.7	1.3	0.8	0.9
Leg fat mass (right)	0.8	3.1	7.2	-2.7	1.3	-0.7
Suffer from ‘nerves’	0.8	1.2	2.3	-1.1	1.5	0.1
Had major operations	0.8	0.9	1.6	1.3	-0.6	-0.8
Medication: Aspirin	0.8	1.0	2.8	0.2	-0.6	1.7
Knee pain experienced in last month	0.8	1.3	2.3	0.9	1.5	0.9
Friendships satisfaction	0.8	1.0	2.6	-1.6	-0.1	0.7
Financial situation satisfaction	0.8	1.0	2.5	1.6	-0.6	-0.5
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.2	0.1	1.5	-0.9
Neuroticism (Nagel 2018)	0.7	1.6	2.5	-1.6	1.6	-0.2
Prostate Cancer	0.7	1.0	1.7	-0.2	-1.1	-1.3
High blood pressure (mother)	0.7	0.9	2.2	0.7	-0.4	1.5
Hip circumference	0.7	3.2	4.8	-1.9	1.0	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	4.8	-1.2	-2.2	0.1
Arm fat mass (right)	0.7	2.7	5.5	-2.4	1.0	-1.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.8	-1.3	0.9	-1.0
Gout (self-reported)	0.7	1.0	1.4	0.8	0.9	1.2
Birth weight	0.7	1.4	1.7	1.1	-1.1	-1.3
Age at first live birth	0.7	1.2	3.4	0.5	-0.2	-1.8
Pulse rate, automated reading	0.7	2.2	4.4	-1.2	2.1	-0.7
Family relationship satisfaction	0.7	0.8	1.3	-0.4	-1.0	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.9	1.4	0.8	0.2
Long-standing illness, disability or infirmity	0.7	1.0	2.6	0.1	1.6	0.7
Eye problems/disorders: Cataract	0.7	0.8	2.0	-1.4	0.1	-0.6
Arm fat mass (left)	0.7	2.7	5.7	-2.4	1.0	-1.2
Alcohol drinker status: Never	0.7	0.9	2.0	-0.3	0.8	1.4
Number of operations (self-reported)	0.7	1.0	2.9	1.7	-0.4	-0.3
Risk taking	0.7	1.0	2.4	0.8	0.0	-1.5
Unable to work because of sickness or disability	0.7	0.9	2.1	0.8	-1.4	-0.1
Bipolar Disorder (2018)	0.6	1.0	2.2	-0.2	0.8	-1.5
Alzheimer’s Disease (including proxy)	0.6	0.8	1.8	0.1	0.8	-1.4
Mean Putamen Volume	0.6	0.6	1.4	-0.5	-0.5	-1.2
Fasting Glucose	0.6	0.7	1.2	-1.1	-0.9	-0.2
Rheumatoid Arthritis	0.6	0.8	1.7	0.9	0.0	1.3
Ulcerative Colitis	0.6	0.9	1.5	0.1	1.1	-1.2
Cardiovascular Disease	0.6	2.0	4.2	2.0	0.1	1.4
Sensitivity / hurt feelings	0.6	1.1	1.2	-1.1	-0.9	1.1
Fed-up feelings	0.6	1.1	1.3	-1.0	1.1	-1.0
Taking other prescription medications	0.6	1.0	2.0	0.8	-0.6	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.5	-0.3	1.2	-1.2
Had menopause	0.6	0.8	1.8	-1.4	0.6	-0.2
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.6	-1.3	-0.1	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.9	0.1	-1.4	0.5
Medication: Blood pressure	0.6	1.1	2.8	1.7	-0.7	-0.0
Angina (self-reported)	0.6	0.8	1.4	0.3	-0.9	1.2
Medication: Allopurinol	0.6	0.8	1.4	1.2	0.9	0.4
Mean time to correctly identify matches	0.6	1.2	2.2	0.4	1.1	-1.5
Alcohol intake frequency.	0.6	1.3	3.7	0.2	1.9	0.5
Age at last live birth	0.6	0.9	2.3	1.5	0.4	-0.5
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.5	0.7	0.0	-1.2
Back pain experienced in last month	0.6	0.9	1.0	-0.9	-1.0	-0.9
Medication: Aspirin	0.6	0.8	1.9	0.5	-0.5	1.4
Ever taken oral contraceptive pill	0.6	0.7	1.9	1.4	0.1	-0.4
Medication: Blood pressure	0.6	1.1	2.3	0.7	0.6	1.5
High cholesterol (Self-reported)	0.6	1.1	2.5	0.3	0.9	1.6
Heart disease (siblings)	0.6	0.7	1.6	-0.6	0.4	1.3
Impedance of whole body	0.6	3.2	7.0	-2.6	0.7	-1.5
Depressed Affect (Nagel 2018)	0.5	1.1	2.5	-0.4	1.6	-0.7
Schizophrenia vs Biploar Disorder	0.5	0.6	1.4	0.6	-0.4	-1.2
Body Mass Index (BMI) (2010)	0.5	0.7	1.0	0.6	1.0	-0.9
Average weekly spirits intake	0.5	0.6	1.1	-0.6	1.0	0.7
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.2	0.1	0.0	-1.5
Medication for hormone replacement therapy	0.5	0.6	1.3	-1.1	-0.3	-0.6
Diabetes (father)	0.5	0.6	0.9	-0.6	0.7	-0.9
Leg fat-free mass (left)	0.5	2.6	4.3	-2.1	1.1	1.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.5	-0.2	1.2	-0.5
Chronic bronchitis/emphysema (father)	0.5	0.6	1.0	-0.2	1.0	-0.8
Leg predicted mass (left)	0.5	2.5	4.1	-2.0	1.1	1.6
Fluid intelligence score	0.5	1.0	2.4	-1.6	0.8	0.1
Arm fat percentage (right)	0.5	2.2	5.1	-1.2	-0.1	-2.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	2.8	-1.6	-1.7	0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.9	-1.1	-0.3	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.5	0.2	0.3	-1.2
Illnesses of mother	0.5	0.7	1.6	1.3	0.7	0.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.2	1.1	0.2	0.8
Headache pain in last month	0.5	0.8	2.2	0.5	-0.0	1.5
Glaucoma (self-reported)	0.5	0.6	1.2	-0.6	1.1	-0.5
Forced vital capacity (FVC), Best measure	0.5	1.9	3.2	-1.6	-1.8	-0.1
Comparative body size at age 10	0.5	1.4	3.8	0.7	-1.9	0.1
Shortness of breath walking on level ground	0.5	0.6	1.6	0.0	1.3	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.2	0.5	1.1	-0.7
Mood swings	0.5	0.9	1.3	-0.4	1.1	1.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.4	-0.9	-1.2	-0.1
Mineral and other dietary supplements	0.5	0.7	1.5	-0.1	-0.7	1.2
Leg predicted mass (right)	0.5	2.4	3.3	-1.8	1.2	1.6
Average weekly champagne plus white wine intake	0.5	0.7	1.5	0.4	-1.2	-0.6
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-0.8	1.1	-0.3
Medication: Lisinopril	0.5	0.6	1.1	-1.1	0.8	-0.3
Irritability	0.5	0.8	1.5	-0.9	1.2	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.5	-1.2	-0.9	0.6
Bipolar Disorder (2011)	0.4	0.4	1.0	-0.1	0.3	1.0
Blood Eosinophil Count	0.4	2.8	4.9	-1.7	0.7	2.2
Heel T-Score	0.4	3.3	5.5	2.3	-1.8	1.2
Serious illness, injury or assault to yourself	0.4	0.5	1.2	0.5	-1.1	-0.0
Allergy	0.4	0.9	1.3	1.1	-0.5	-1.2
Noisy workplace	0.4	0.5	1.1	-0.3	-1.1	-0.6
Blood clot in the leg (DVT)	0.4	0.5	1.1	-0.5	1.1	0.2
Medication: Paracetamol	0.4	0.7	1.5	-0.7	1.2	0.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.5	-1.2	0.0	0.2
Leg fat-free mass (right)	0.4	2.3	3.5	-1.9	1.1	1.5
Arm fat percentage (left)	0.4	1.8	3.8	-1.2	-0.2	-2.0
Average weekly red wine intake	0.4	0.6	1.3	0.2	0.7	1.1
Osteoporosis (self-reported)	0.4	0.5	0.9	0.8	1.0	-0.3
Age started oral contraceptive pill	0.4	0.5	0.9	-0.2	-0.8	1.0
Worry (Nagel 2018)	0.3	0.6	1.0	-0.8	1.0	0.0
Major Depression (MDD)	0.3	0.4	1.0	1.0	0.4	0.1
Schizophrenia (2014)	0.3	0.6	1.3	-0.6	1.1	-0.3
Blood Platelet Count	0.3	3.3	4.8	0.8	2.2	2.1
Lung FEV1/FVC ratio	0.3	1.3	1.9	-1.2	-1.4	0.7
Pack years adult smoking proportion	0.3	0.5	0.7	-0.6	0.8	-0.6
Hand grip strength (right)	0.3	0.8	1.8	-1.3	0.7	-0.1
Age when periods started (menarche)	0.3	0.7	1.1	0.9	-1.0	0.3
Past tobacco smoking	0.3	0.6	1.5	0.4	0.3	-1.2
Nervous feelings	0.3	0.6	1.6	0.0	1.2	-0.4
Had other major operations	0.3	0.3	0.8	0.0	0.9	0.4
Heart attack	0.3	0.4	0.7	-0.6	0.1	-0.8
Diabetes (self-reported)	0.3	0.4	0.7	0.7	-0.8	0.1
Medication: Simvastatin	0.3	0.5	1.3	-0.2	-0.4	1.2
Impedance of arm (right)	0.3	1.6	3.9	-0.8	-0.5	-2.0
Father’s age at death	0.3	0.4	0.7	-0.8	0.3	-0.7
Lung cancer (father)	0.3	0.3	0.9	1.0	0.1	0.3
Impedance of arm (left)	0.3	1.5	3.6	-0.9	-0.5	-1.9
Worry too long after embarrassment	0.3	0.5	1.4	-1.2	0.1	0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.6	0.4	0.8	0.5
Medication: Omeprazole	0.3	0.4	0.7	0.5	0.3	0.8
Illnesses of father: Heart disease	0.3	0.4	0.6	0.8	-0.8	0.2
Smoking status: Previous	0.3	0.5	1.1	-0.2	-0.4	1.1
Qualifications: nursing, teaching	0.3	0.5	1.0	-0.7	-0.0	1.0
Ever smoked	0.3	0.6	1.3	-0.5	-1.2	0.3
Pain experienced in last month	0.3	0.5	0.6	-0.7	-0.6	-0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.6	-0.2	-0.8
Alcohol drinker status: Previous	0.3	0.4	0.6	0.8	-0.4	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.8	-0.9	-0.8	-0.2
Reaction Time	0.2	0.3	1.0	0.1	1.0	0.1
Age at First Birth	0.2	0.3	0.8	-0.9	-0.3	0.4
Crohns Disease (2012)	0.2	0.3	0.5	-0.3	0.7	-0.4
Blood White Count	0.2	1.8	2.7	-0.8	1.4	-1.6
BMI	0.2	1.4	3.4	-0.1	-0.8	-1.9
Allergy or Eczema	0.2	0.4	0.8	-0.7	0.1	0.9
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	0.8	-0.5	0.6
Tanning	0.2	2.1	3.2	1.5	-0.9	-1.8
Number of treatments/medications taken	0.2	0.4	1.1	-1.0	0.1	0.5
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.2	-0.2	-0.9
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.4	-0.5	0.5
Medication: Metformin	0.2	0.2	0.6	0.4	0.0	0.8
Supplements: Glucosamine	0.2	0.3	0.6	-0.8	0.5	-0.3
Hearing difficulty/problems with background noise	0.2	0.3	0.7	-0.5	-0.8	-0.1
Forced vital capacity (FVC)	0.2	1.0	1.6	-1.3	-1.1	0.1
Neuroticism score	0.2	0.5	1.0	-0.5	1.0	0.4
Time employed in main current job	0.2	0.2	0.6	0.2	0.2	0.8
Asthma	0.2	0.4	0.7	0.7	-0.5	0.8
Depression (self-reported)	0.2	0.2	0.3	-0.3	-0.6	-0.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	-0.6	-0.5	-0.2
Exposure to tobacco smoke outside home	0.2	0.2	0.3	-0.5	-0.4	-0.5
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	0.7	0.8	-0.2
Pulse wave peak to peak time	0.2	0.3	0.8	0.1	0.9	0.1
Qualifications: College or University degree	0.2	0.6	1.2	-0.1	-0.9	-1.1
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.2	-0.2	0.8
Medication for pain relief, constipation, heartburn	0.2	0.4	0.7	0.9	-0.2	-0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.4	0.5	-0.4
Loneliness, isolation	0.2	0.2	0.6	-0.2	0.7	-0.2
Ever had bowel cancer screening	0.2	0.2	0.6	-0.8	-0.3	-0.2
Asthma (self-reported)	0.2	0.4	0.6	0.8	-0.4	0.8
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	0.0	-0.6	-0.6
Miserableness	0.2	0.4	0.8	-0.5	0.9	0.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.7	0.0	-0.3	-0.8
Average weekly beer plus cider intake	0.2	0.4	0.8	0.9	0.2	0.5
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	0.7	0.2	0.5
Pack years of smoking	0.2	0.4	0.7	-0.2	0.6	-0.9
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.3	0.8	-0.6
Schizophrenia (2018)	0.1	0.1	0.2	-0.3	0.3	0.5
Crohns Disease (2017)	0.1	0.2	0.5	-0.2	-0.7	0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	0.0	0.1	-0.9
HDL Cholesterol	0.1	0.2	0.6	0.0	0.8	0.2
LDL Cholesterol	0.1	0.1	0.3	-0.3	0.3	0.5
Blood Red Count	0.1	1.2	3.2	0.2	0.6	1.8
Smoking Status	0.1	0.3	0.6	-0.8	-0.5	0.1
Respiratory disease	0.1	0.2	0.2	0.3	0.5	0.5
Neuroticism	0.1	0.3	0.5	-0.6	0.7	0.2
Chronotype (morning person)	0.1	0.2	0.4	0.6	0.4	-0.1
Hair Pigment	0.1	4.1	5.2	-2.3	1.4	-2.3
Hand grip strength (left)	0.1	0.4	0.9	-0.1	-0.9	0.5
Relative age of first facial hair	0.1	0.2	0.3	-0.5	-0.1	0.4
Severe depression (siblings)	0.1	0.1	0.2	0.2	0.5	-0.4
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.4	0.5	0.2
Current tobacco smoking	0.1	0.1	0.2	-0.1	-0.4	-0.3
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.4	-0.6	-0.0	-0.1
Multivitamins +/- minerals	0.1	0.1	0.2	0.3	0.4	-0.1
Body mass index (BMI)	0.1	0.5	1.2	-0.5	0.4	-1.1
Alcohol usually taken with meals	0.1	0.1	0.2	0.4	-0.5	-0.2
Qualifications: None of the above	0.1	0.3	0.4	-0.1	-0.7	0.6
Worrier / anxious feelings	0.1	0.3	0.5	-0.4	0.7	-0.2
Prospective memory result	0.1	0.1	0.2	-0.5	0.1	-0.1
Length of working week for main job	0.1	0.1	0.4	-0.6	0.1	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.6	0.3	-0.0
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.2	0.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.5	-0.3	-0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.4	0.0	0.1	0.6
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.8	0.2	0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.4	0.5	0.2
Ever depressed for a whole week	0.1	0.2	0.3	0.6	-0.3	-0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.0	0.2	0.4
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	-0.2	0.0	-0.3
Overall health rating	0.0	0.1	0.2	0.3	-0.0	0.5
Smoking status: Current	0.0	0.0	0.1	-0.0	0.0	-0.3
Guilty feelings	0.0	0.1	0.1	0.1	0.4	-0.2

Hub : Genes

COL8A1

Models

Trait associations