Best TWAS P=1.54e-158 · Best GWAS P=5.99e-142 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FAM184B | 0.14 | 0.25 | enet | 21 | 0.24 | 2.0e-28 | -7.266 | 7.2 | 6.3e-13 | -0.14 | 1.00 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | LAP3 | 0.05 | 0.06 | lasso | 2 | 0.05 | 4.8e-07 | -6.060 | -6.5 | 6.5e-11 | 0.11 | 1.00 | 0.00 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | MED28 | 0.07 | 0.09 | enet | 9 | 0.11 | 7.1e-13 | -7.339 | 8.3 | 7.6e-17 | -0.18 | 1.00 | 0.00 | FALSE |
4 | GTEx | Adipose Subcutaneous | DCAF16 | 0.21 | 0.15 | lasso | 3 | 0.17 | 5.1e-14 | 16.956 | 16.4 | 8.6e-61 | -0.24 | 1.00 | 0.00 | FALSE |
5 | GTEx | Adipose Visceral Omentum | DCAF16 | 0.19 | 0.06 | enet | 10 | 0.11 | 3.9e-06 | 16.956 | 18.5 | 2.2e-76 | -0.35 | 0.34 | 0.37 | TRUE |
6 | GTEx | Artery Aorta | DCAF16 | 0.10 | 0.01 | enet | 6 | 0.02 | 4.7e-02 | -23.296 | 26.8 | 1.5e-158 | -0.81 | 0.07 | 0.70 | TRUE |
7 | GTEx | Artery Tibial | DCAF16 | 0.16 | 0.16 | lasso | 5 | 0.13 | 1.5e-10 | 18.843 | 20.9 | 5.2e-97 | -0.36 | 1.00 | 0.00 | FALSE |
8 | GTEx | Breast Mammary Tissue | DCAF16 | 0.12 | 0.08 | lasso | 4 | 0.10 | 6.4e-06 | 17.073 | 21.4 | 5.1e-102 | -0.52 | 0.11 | 0.73 | TRUE |
9 | GTEx | Breast Mammary Tissue (Male) | DCAF16 | 0.24 | 0.03 | enet | 18 | -0.01 | 4.4e-01 | -22.642 | 24.3 | 8.3e-131 | -0.76 | 0.04 | 0.65 | FALSE |
10 | GTEx | Breast Mammary Tissue (Female) | DCAF16 | 0.16 | 0.13 | lasso | 2 | 0.06 | 7.8e-03 | 16.956 | 16.9 | 2.3e-64 | -0.27 | 0.06 | 0.10 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | LAP3 | 0.20 | 0.12 | lasso | 6 | 0.13 | 3.0e-10 | -7.271 | -7.0 | 3.1e-12 | 0.13 | 1.00 | 0.00 | FALSE |
12 | GTEx | Colon Transverse | MED28 | 0.13 | 0.05 | lasso | 3 | 0.02 | 5.8e-02 | -6.107 | 6.1 | 1.0e-09 | -0.11 | 0.20 | 0.04 | FALSE |
13 | GTEx | Esophagus Mucosa | DCAF16 | 0.10 | 0.02 | lasso | 4 | 0.02 | 8.3e-03 | 17.073 | 18.7 | 3.7e-78 | -0.37 | 0.14 | 0.37 | FALSE |
14 | GTEx | Esophagus Muscularis | DCAF16 | 0.16 | 0.14 | lasso | 3 | 0.14 | 9.3e-09 | 16.956 | 16.9 | 6.8e-64 | -0.27 | 0.99 | 0.00 | FALSE |
15 | GTEx | Muscle Skeletal | MED28 | 0.05 | 0.03 | enet | 8 | 0.02 | 3.1e-03 | -7.171 | 7.3 | 3.8e-13 | -0.14 | 0.56 | 0.02 | FALSE |
16 | GTEx | Nerve Tibial | DCAF16 | 0.16 | 0.14 | lasso | 3 | 0.14 | 2.8e-10 | 16.956 | 19.0 | 1.3e-80 | -0.37 | 0.99 | 0.01 | FALSE |
17 | GTEx | Pituitary | DCAF16 | 0.27 | 0.20 | enet | 15 | 0.19 | 1.3e-05 | 16.956 | 15.6 | 6.3e-55 | -0.38 | 0.08 | 0.27 | FALSE |
18 | GTEx | Skin Not Sun Exposed Suprapubic | DCAF16 | 0.16 | 0.08 | lasso | 5 | 0.12 | 4.4e-07 | 16.919 | 18.9 | 1.2e-79 | -0.35 | 0.64 | 0.04 | TRUE |
19 | GTEx | Skin Sun Exposed Lower leg | QDPR | 0.11 | 0.04 | enet | 22 | 0.08 | 4.8e-07 | 0.519 | 5.8 | 8.6e-09 | -0.29 | 0.27 | 0.42 | TRUE |
20 | GTEx | Skin Sun Exposed Lower leg | DCAF16 | 0.14 | 0.12 | enet | 14 | 0.12 | 5.4e-10 | 17.073 | 18.5 | 1.3e-76 | -0.28 | 1.00 | 0.00 | FALSE |
21 | GTEx | Spleen | LAP3 | 0.15 | 0.16 | lasso | 3 | 0.15 | 1.3e-04 | -5.077 | -6.2 | 4.6e-10 | 0.13 | 0.39 | 0.05 | FALSE |
22 | GTEx | Spleen | DCAF16 | 0.35 | 0.02 | lasso | 5 | 0.11 | 8.5e-04 | 16.956 | 25.2 | 1.2e-140 | -0.66 | 0.04 | 0.63 | FALSE |
23 | GTEx | Stomach | DCAF16 | 0.21 | 0.04 | lasso | 6 | 0.02 | 5.6e-02 | 18.752 | 20.4 | 1.8e-92 | -0.26 | 0.19 | 0.05 | TRUE |
24 | GTEx | Testis | LAP3 | 0.28 | 0.19 | lasso | 3 | 0.19 | 5.1e-09 | -6.071 | -6.4 | 1.6e-10 | 0.11 | 1.00 | 0.00 | FALSE |
25 | GTEx | Thyroid | DCAF16 | 0.11 | 0.02 | lasso | 5 | 0.03 | 2.3e-03 | 16.956 | 24.1 | 2.6e-128 | -0.54 | 0.20 | 0.65 | FALSE |
26 | GTEx | Whole Blood | LAP3 | 0.06 | 0.02 | enet | 7 | 0.02 | 1.1e-02 | -6.069 | -6.2 | 6.3e-10 | 0.12 | 0.69 | 0.02 | FALSE |
27 | NTR | Blood | LAP3 | 0.06 | 0.07 | lasso | 5 | 0.07 | 1.6e-22 | -6.071 | -6.0 | 2.6e-09 | 0.10 | 1.00 | 0.00 | FALSE |
28 | NTR | Blood | MED28 | 0.09 | 0.18 | lasso | 2 | 0.18 | 3.7e-54 | -7.171 | 7.4 | 1.5e-13 | -0.16 | 1.00 | 0.00 | FALSE |
29 | ROSMAP | Brain Pre-frontal Cortex | LAP3 | 0.12 | 0.09 | lasso | 6 | 0.10 | 1.9e-12 | -6.001 | -6.0 | 2.7e-09 | 0.10 | 1.00 | 0.00 | FALSE |
30 | ROSMAP | Brain Pre-frontal Cortex | FAM184B | 0.17 | 0.14 | enet | 31 | 0.18 | 5.1e-23 | -7.339 | -10.9 | 7.0e-28 | 0.26 | 1.00 | 0.00 | TRUE |
31 | ROSMAP | Brain Pre-frontal Cortex | MED28 | 0.02 | 0.01 | bslmm | 411 | 0.00 | 1.9e-01 | -7.403 | 10.3 | 9.0e-25 | -0.30 | 0.22 | 0.03 | FALSE |
32 | ROSMAP | Brain Pre-frontal Cortex | DCAF16 | 0.04 | 0.02 | bslmm | 379 | 0.01 | 3.9e-02 | -22.680 | 22.5 | 1.8e-112 | -0.83 | 0.03 | 0.88 | FALSE |
33 | YFS | Blood | DCAF16 | 0.02 | 0.02 | lasso | 1 | 0.01 | 1.1e-04 | 18.843 | 18.8 | 3.4e-79 | -0.25 | 0.84 | 0.03 | FALSE |
34 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MED28 | 0.02 | 0.01 | enet | 4 | 0.01 | 4.0e-03 | -5.784 | 5.8 | 6.9e-09 | -0.11 | 0.04 | 0.72 | FALSE |
35 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NCAPG | 0.03 | 0.04 | enet | 5 | 0.04 | 8.1e-09 | 0.089 | -8.5 | 1.6e-17 | 0.55 | 0.95 | 0.04 | TRUE |
36 | The Cancer Genome Atlas | Colon Adenocarcinoma | NCAPG | 0.08 | 0.04 | blup | 34 | 0.09 | 1.1e-05 | -22.700 | -19.9 | 4.5e-88 | 0.84 | 0.06 | 0.91 | FALSE |
37 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FAM184B | 0.02 | 0.03 | lasso | 2 | 0.02 | 2.6e-03 | -7.723 | -7.8 | 7.4e-15 | 0.16 | 0.24 | 0.03 | FALSE |
38 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LAP3 | 0.09 | 0.06 | lasso | 2 | 0.05 | 3.3e-06 | -6.107 | -6.2 | 4.7e-10 | 0.13 | 0.35 | 0.63 | FALSE |
39 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NCAPG | 0.14 | 0.07 | lasso | 3 | 0.07 | 5.2e-08 | -22.680 | -22.0 | 1.4e-107 | 0.84 | 0.99 | 0.00 | FALSE |
40 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LAP3 | 0.04 | 0.08 | enet | 5 | 0.08 | 1.9e-09 | -6.001 | -6.1 | 1.0e-09 | 0.10 | 0.08 | 0.92 | FALSE |
41 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DCAF16 | 0.09 | 0.02 | lasso | 3 | 0.04 | 5.2e-05 | 18.843 | 25.8 | 9.3e-147 | -0.64 | 0.04 | 0.91 | FALSE |
42 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LAP3 | 0.03 | 0.03 | blup | 36 | 0.03 | 2.4e-04 | -5.784 | -6.5 | 9.5e-11 | 0.11 | 0.08 | 0.82 | FALSE |
43 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MED28 | 0.07 | 0.06 | lasso | 2 | 0.06 | 4.5e-07 | -7.201 | 6.7 | 2.8e-11 | -0.12 | 0.04 | 0.96 | FALSE |
44 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NCAPG | 0.02 | 0.03 | lasso | 1 | 0.02 | 9.0e-04 | -22.700 | -22.7 | 4.5e-114 | 0.88 | 0.03 | 0.54 | FALSE |
45 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | MED28 | 0.08 | 0.05 | blup | 34 | 0.05 | 2.9e-03 | -7.189 | 7.6 | 3.8e-14 | -0.17 | 0.02 | 0.75 | FALSE |
46 | The Cancer Genome Atlas | Lung Adenocarcinoma | MED28 | 0.02 | 0.01 | blup | 34 | 0.01 | 8.5e-03 | -7.271 | 7.2 | 8.9e-13 | -0.14 | 0.03 | 0.81 | FALSE |
47 | The Cancer Genome Atlas | Lung Adenocarcinoma | NCAPG | 0.06 | 0.02 | blup | 34 | 0.04 | 1.0e-05 | -22.700 | -13.1 | 5.1e-39 | 0.68 | 0.13 | 0.05 | FALSE |
48 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LAP3 | 0.02 | 0.02 | lasso | 4 | 0.01 | 2.2e-02 | -7.201 | -7.2 | 6.0e-13 | 0.14 | 0.02 | 0.79 | FALSE |
49 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MED28 | 0.03 | 0.02 | blup | 34 | 0.03 | 2.3e-04 | -6.071 | 6.7 | 1.7e-11 | -0.12 | 0.04 | 0.93 | FALSE |
50 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LAP3 | 0.04 | 0.02 | blup | 36 | 0.02 | 1.5e-02 | -7.210 | -6.6 | 4.5e-11 | 0.14 | 0.01 | 0.72 | FALSE |
51 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | MED28 | 0.10 | 0.12 | enet | 8 | 0.12 | 1.6e-05 | -7.266 | 7.1 | 1.4e-12 | -0.12 | 0.03 | 0.94 | FALSE |
52 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DCAF16 | 0.04 | 0.04 | blup | 31 | 0.04 | 2.2e-05 | 16.956 | 23.7 | 4.3e-124 | -0.58 | 0.26 | 0.26 | FALSE |
53 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MED28 | 0.06 | 0.05 | enet | 3 | 0.07 | 1.7e-07 | -7.158 | 6.4 | 1.3e-10 | -0.14 | 0.03 | 0.97 | FALSE |
54 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NCAPG | 0.02 | 0.02 | blup | 34 | 0.02 | 3.4e-03 | -21.500 | -19.6 | 1.1e-85 | 0.76 | 0.01 | 0.88 | FALSE |
55 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LAP3 | 0.07 | 0.03 | blup | 36 | 0.06 | 5.3e-05 | -5.107 | -7.3 | 2.6e-13 | 0.15 | 0.03 | 0.97 | FALSE |
56 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | MED28 | 0.08 | 0.05 | lasso | 3 | 0.05 | 8.7e-03 | -6.069 | 6.8 | 1.4e-11 | -0.12 | 0.02 | 0.69 | FALSE |
57 | The Cancer Genome Atlas | Thyroid Carcinoma | DCAF16 | 0.07 | 0.04 | blup | 31 | 0.07 | 4.9e-07 | 18.752 | 24.4 | 6.5e-132 | -0.65 | 0.15 | 0.77 | FALSE |
58 | The Cancer Genome Atlas | Thyroid Carcinoma | MED28 | 0.03 | 0.03 | blup | 34 | 0.02 | 3.4e-03 | -7.158 | 7.0 | 1.7e-12 | -0.14 | 0.02 | 0.68 | FALSE |