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chr4:16,767,708-18,507,692

Best TWAS P=1.54e-158 · Best GWAS P=5.99e-142 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Artery Aorta	DCAF16	0.10	0.01	enet	6	0.02	4.7e-02	-23.296	26.8	1.5e-158	-0.81	0.07	0.70	TRUE
8	GTEx	Breast Mammary Tissue	DCAF16	0.12	0.08	lasso	4	0.10	6.4e-06	17.073	21.4	5.1e-102	-0.52	0.11	0.73	TRUE
23	GTEx	Stomach	DCAF16	0.21	0.04	lasso	6	0.02	5.6e-02	18.752	20.4	1.8e-92	-0.26	0.19	0.05	TRUE
18	GTEx	Skin Not Sun Exposed Suprapubic	DCAF16	0.16	0.08	lasso	5	0.12	4.4e-07	16.919	18.9	1.2e-79	-0.35	0.64	0.04	TRUE
5	GTEx	Adipose Visceral Omentum	DCAF16	0.19	0.06	enet	10	0.11	3.9e-06	16.956	18.5	2.2e-76	-0.35	0.34	0.37	TRUE
30	ROSMAP	Brain Pre-frontal Cortex	FAM184B	0.17	0.14	enet	31	0.18	5.1e-23	-7.339	-10.9	7.0e-28	0.26	1.00	0.00	TRUE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	NCAPG	0.03	0.04	enet	5	0.04	8.1e-09	0.089	-8.5	1.6e-17	0.55	0.95	0.04	TRUE
19	GTEx	Skin Sun Exposed Lower leg	QDPR	0.11	0.04	enet	22	0.08	4.8e-07	0.519	5.8	8.6e-09	-0.29	0.27	0.42	TRUE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	DCAF16	0.09	0.02	lasso	3	0.04	5.2e-05	18.843	25.8	9.3e-147	-0.64	0.04	0.91	FALSE
22	GTEx	Spleen	DCAF16	0.35	0.02	lasso	5	0.11	8.5e-04	16.956	25.2	1.2e-140	-0.66	0.04	0.63	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	DCAF16	0.07	0.04	blup	31	0.07	4.9e-07	18.752	24.4	6.5e-132	-0.65	0.15	0.77	FALSE
9	GTEx	Breast Mammary Tissue (Male)	DCAF16	0.24	0.03	enet	18	-0.01	4.4e-01	-22.642	24.3	8.3e-131	-0.76	0.04	0.65	FALSE
25	GTEx	Thyroid	DCAF16	0.11	0.02	lasso	5	0.03	2.3e-03	16.956	24.1	2.6e-128	-0.54	0.20	0.65	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	DCAF16	0.04	0.04	blup	31	0.04	2.2e-05	16.956	23.7	4.3e-124	-0.58	0.26	0.26	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	NCAPG	0.02	0.03	lasso	1	0.02	9.0e-04	-22.700	-22.7	4.5e-114	0.88	0.03	0.54	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	DCAF16	0.04	0.02	bslmm	379	0.01	3.9e-02	-22.680	22.5	1.8e-112	-0.83	0.03	0.88	FALSE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NCAPG	0.14	0.07	lasso	3	0.07	5.2e-08	-22.680	-22.0	1.4e-107	0.84	0.99	0.00	FALSE
7	GTEx	Artery Tibial	DCAF16	0.16	0.16	lasso	5	0.13	1.5e-10	18.843	20.9	5.2e-97	-0.36	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Colon Adenocarcinoma	NCAPG	0.08	0.04	blup	34	0.09	1.1e-05	-22.700	-19.9	4.5e-88	0.84	0.06	0.91	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	NCAPG	0.02	0.02	blup	34	0.02	3.4e-03	-21.500	-19.6	1.1e-85	0.76	0.01	0.88	FALSE
16	GTEx	Nerve Tibial	DCAF16	0.16	0.14	lasso	3	0.14	2.8e-10	16.956	19.0	1.3e-80	-0.37	0.99	0.01	FALSE
33	YFS	Blood	DCAF16	0.02	0.02	lasso	1	0.01	1.1e-04	18.843	18.8	3.4e-79	-0.25	0.84	0.03	FALSE
13	GTEx	Esophagus Mucosa	DCAF16	0.10	0.02	lasso	4	0.02	8.3e-03	17.073	18.7	3.7e-78	-0.37	0.14	0.37	FALSE
20	GTEx	Skin Sun Exposed Lower leg	DCAF16	0.14	0.12	enet	14	0.12	5.4e-10	17.073	18.5	1.3e-76	-0.28	1.00	0.00	FALSE
10	GTEx	Breast Mammary Tissue (Female)	DCAF16	0.16	0.13	lasso	2	0.06	7.8e-03	16.956	16.9	2.3e-64	-0.27	0.06	0.10	FALSE
14	GTEx	Esophagus Muscularis	DCAF16	0.16	0.14	lasso	3	0.14	9.3e-09	16.956	16.9	6.8e-64	-0.27	0.99	0.00	FALSE
4	GTEx	Adipose Subcutaneous	DCAF16	0.21	0.15	lasso	3	0.17	5.1e-14	16.956	16.4	8.6e-61	-0.24	1.00	0.00	FALSE
17	GTEx	Pituitary	DCAF16	0.27	0.20	enet	15	0.19	1.3e-05	16.956	15.6	6.3e-55	-0.38	0.08	0.27	FALSE
47	The Cancer Genome Atlas	Lung Adenocarcinoma	NCAPG	0.06	0.02	blup	34	0.04	1.0e-05	-22.700	-13.1	5.1e-39	0.68	0.13	0.05	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	MED28	0.02	0.01	bslmm	411	0.00	1.9e-01	-7.403	10.3	9.0e-25	-0.30	0.22	0.03	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MED28	0.07	0.09	enet	9	0.11	7.1e-13	-7.339	8.3	7.6e-17	-0.18	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FAM184B	0.02	0.03	lasso	2	0.02	2.6e-03	-7.723	-7.8	7.4e-15	0.16	0.24	0.03	FALSE
45	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MED28	0.08	0.05	blup	34	0.05	2.9e-03	-7.189	7.6	3.8e-14	-0.17	0.02	0.75	FALSE
28	NTR	Blood	MED28	0.09	0.18	lasso	2	0.18	3.7e-54	-7.171	7.4	1.5e-13	-0.16	1.00	0.00	FALSE
55	The Cancer Genome Atlas	Stomach Adenocarcinoma	LAP3	0.07	0.03	blup	36	0.06	5.3e-05	-5.107	-7.3	2.6e-13	0.15	0.03	0.97	FALSE
15	GTEx	Muscle Skeletal	MED28	0.05	0.03	enet	8	0.02	3.1e-03	-7.171	7.3	3.8e-13	-0.14	0.56	0.02	FALSE
48	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LAP3	0.02	0.02	lasso	4	0.01	2.2e-02	-7.201	-7.2	6.0e-13	0.14	0.02	0.79	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM184B	0.14	0.25	enet	21	0.24	2.0e-28	-7.266	7.2	6.3e-13	-0.14	1.00	0.00	FALSE
46	The Cancer Genome Atlas	Lung Adenocarcinoma	MED28	0.02	0.01	blup	34	0.01	8.5e-03	-7.271	7.2	8.9e-13	-0.14	0.03	0.81	FALSE
51	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MED28	0.10	0.12	enet	8	0.12	1.6e-05	-7.266	7.1	1.4e-12	-0.12	0.03	0.94	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	MED28	0.03	0.03	blup	34	0.02	3.4e-03	-7.158	7.0	1.7e-12	-0.14	0.02	0.68	FALSE
11	GTEx	Cells Transformed fibroblasts	LAP3	0.20	0.12	lasso	6	0.13	3.0e-10	-7.271	-7.0	3.1e-12	0.13	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MED28	0.08	0.05	lasso	3	0.05	8.7e-03	-6.069	6.8	1.4e-11	-0.12	0.02	0.69	FALSE
49	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MED28	0.03	0.02	blup	34	0.03	2.3e-04	-6.071	6.7	1.7e-11	-0.12	0.04	0.93	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	MED28	0.07	0.06	lasso	2	0.06	4.5e-07	-7.201	6.7	2.8e-11	-0.12	0.04	0.96	FALSE
50	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LAP3	0.04	0.02	blup	36	0.02	1.5e-02	-7.210	-6.6	4.5e-11	0.14	0.01	0.72	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LAP3	0.05	0.06	lasso	2	0.05	4.8e-07	-6.060	-6.5	6.5e-11	0.11	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	LAP3	0.03	0.03	blup	36	0.03	2.4e-04	-5.784	-6.5	9.5e-11	0.11	0.08	0.82	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	MED28	0.06	0.05	enet	3	0.07	1.7e-07	-7.158	6.4	1.3e-10	-0.14	0.03	0.97	FALSE
24	GTEx	Testis	LAP3	0.28	0.19	lasso	3	0.19	5.1e-09	-6.071	-6.4	1.6e-10	0.11	1.00	0.00	FALSE
21	GTEx	Spleen	LAP3	0.15	0.16	lasso	3	0.15	1.3e-04	-5.077	-6.2	4.6e-10	0.13	0.39	0.05	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LAP3	0.09	0.06	lasso	2	0.05	3.3e-06	-6.107	-6.2	4.7e-10	0.13	0.35	0.63	FALSE
26	GTEx	Whole Blood	LAP3	0.06	0.02	enet	7	0.02	1.1e-02	-6.069	-6.2	6.3e-10	0.12	0.69	0.02	FALSE
12	GTEx	Colon Transverse	MED28	0.13	0.05	lasso	3	0.02	5.8e-02	-6.107	6.1	1.0e-09	-0.11	0.20	0.04	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LAP3	0.04	0.08	enet	5	0.08	1.9e-09	-6.001	-6.1	1.0e-09	0.10	0.08	0.92	FALSE
27	NTR	Blood	LAP3	0.06	0.07	lasso	5	0.07	1.6e-22	-6.071	-6.0	2.6e-09	0.10	1.00	0.00	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	LAP3	0.12	0.09	lasso	6	0.10	1.9e-12	-6.001	-6.0	2.7e-09	0.10	1.00	0.00	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	MED28	0.02	0.01	enet	4	0.01	4.0e-03	-5.784	5.8	6.9e-09	-0.11	0.04	0.72	FALSE