Best TWAS P=6.55e-42 · Best GWAS P=1.36e-49 conditioned to 2.49e-06
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PPA2 | 0.08 | 0.03 | bslmm | 429 | 0.04 | 2.2e-05 | -9.75 | -9.9 | 2.7e-23 | 0.66 | 0.08 | 0.89 | FALSE |
2 | GTEx | Adipose Subcutaneous | PPA2 | 0.15 | 0.02 | enet | 36 | 0.06 | 7.0e-06 | 7.30 | -6.5 | 7.0e-11 | 0.34 | 0.26 | 0.11 | FALSE |
3 | GTEx | Artery Aorta | PPA2 | 0.11 | -0.01 | enet | 24 | 0.01 | 1.6e-01 | -14.18 | -9.1 | 1.0e-19 | 0.63 | 0.06 | 0.46 | FALSE |
4 | GTEx | Artery Tibial | PPA2 | 0.08 | 0.02 | enet | 19 | 0.04 | 5.0e-04 | -10.16 | -5.2 | 2.0e-07 | 0.51 | 0.17 | 0.18 | TRUE |
5 | GTEx | Brain Cerebellum | PPA2 | 0.22 | 0.01 | lasso | 4 | 0.03 | 3.7e-02 | -10.16 | -8.6 | 6.1e-18 | 0.62 | 0.09 | 0.12 | FALSE |
6 | GTEx | Brain Cortex | PPA2 | 0.14 | 0.09 | lasso | 9 | 0.09 | 1.6e-03 | -11.81 | -12.0 | 5.4e-33 | 0.88 | 0.04 | 0.74 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | PPA2 | 0.11 | 0.03 | lasso | 3 | 0.01 | 6.5e-02 | -8.92 | -10.2 | 3.2e-24 | 0.67 | 0.39 | 0.16 | FALSE |
8 | GTEx | Esophagus Gastroesophageal Junction | PPA2 | 0.29 | 0.15 | lasso | 5 | 0.14 | 8.8e-06 | -14.18 | -13.2 | 6.9e-40 | 0.88 | 0.02 | 0.96 | TRUE |
9 | GTEx | Esophagus Mucosa | PPA2 | 0.18 | 0.06 | enet | 14 | 0.12 | 2.5e-08 | 13.01 | -13.6 | 6.6e-42 | 0.72 | 0.11 | 0.89 | TRUE |
10 | GTEx | Heart Atrial Appendage | PPA2 | 0.15 | 0.05 | lasso | 7 | 0.06 | 7.4e-04 | -11.71 | -7.7 | 1.7e-14 | 0.71 | 0.24 | 0.38 | FALSE |
11 | GTEx | Lung | PPA2 | 0.09 | 0.02 | enet | 16 | 0.03 | 1.4e-03 | 0.88 | -6.0 | 1.8e-09 | 0.45 | 0.19 | 0.34 | TRUE |
12 | GTEx | Muscle Skeletal | PPA2 | 0.19 | 0.06 | enet | 28 | 0.11 | 8.7e-11 | -11.28 | -7.1 | 1.3e-12 | 0.60 | 0.89 | 0.11 | FALSE |
13 | GTEx | Nerve Tibial | PPA2 | 0.13 | 0.07 | enet | 23 | 0.07 | 2.1e-05 | -10.16 | -9.8 | 7.3e-23 | 0.66 | 0.36 | 0.46 | FALSE |
14 | GTEx | Ovary | PPA2 | 0.18 | 0.10 | lasso | 3 | 0.14 | 2.2e-04 | -10.16 | -12.0 | 3.2e-33 | 0.76 | 0.04 | 0.80 | FALSE |
15 | GTEx | Skin Sun Exposed Lower leg | PPA2 | 0.09 | 0.07 | lasso | 3 | 0.04 | 4.3e-04 | 7.20 | -7.6 | 3.0e-14 | 0.35 | 0.65 | 0.04 | FALSE |
16 | GTEx | Skin Sun Exposed Lower leg | TET2 | 0.09 | 0.01 | enet | 18 | 0.02 | 3.6e-03 | -14.79 | -11.5 | 1.6e-30 | 0.69 | 0.01 | 0.95 | FALSE |
17 | GTEx | Thyroid | PPA2 | 0.22 | 0.01 | enet | 18 | 0.12 | 2.9e-09 | 8.36 | -7.8 | 6.3e-15 | 0.54 | 0.74 | 0.07 | FALSE |
18 | METSIM | Adipose | PPA2 | 0.08 | 0.05 | lasso | 2 | 0.04 | 3.7e-07 | 7.20 | 7.1 | 1.3e-12 | -0.26 | 0.96 | 0.00 | FALSE |
19 | ROSMAP | Brain Pre-frontal Cortex | PPA2 | 0.32 | 0.38 | lasso | 2 | 0.38 | 1.1e-51 | 7.20 | -8.0 | 1.4e-15 | 0.45 | 1.00 | 0.00 | FALSE |
20 | YFS | Blood | PPA2 | 0.22 | 0.05 | lasso | 19 | 0.12 | 9.7e-38 | -3.71 | 7.3 | 3.2e-13 | -0.51 | 1.00 | 0.00 | FALSE |
21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPA2 | 0.11 | 0.03 | blup | 84 | 0.03 | 4.7e-04 | -10.16 | -5.7 | 1.1e-08 | 0.59 | 0.18 | 0.68 | FALSE |
22 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PPA2 | 0.29 | 0.01 | blup | 84 | 0.10 | 4.3e-06 | -7.06 | -5.2 | 2.5e-07 | 0.37 | 0.13 | 0.12 | FALSE |
23 | The Cancer Genome Atlas | Thyroid Carcinoma | PPA2 | 0.04 | 0.02 | blup | 84 | 0.04 | 6.1e-05 | -11.28 | -10.1 | 6.8e-24 | 0.77 | 0.14 | 0.65 | FALSE |