Best TWAS P=1.78e-19 · Best GWAS P=4.41e-25 conditioned to 1.27e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | CSNK1G3 | 0.11 | 0.07 | lasso | 2 | 0.01 | 6.5e-02 | -6.0 | -6.1 | 1.4e-09 | 0.52 | 0.15 | 0.09 | FALSE |
| 2 | GTEx | Artery Aorta | KRT8P33 | 0.10 | 0.04 | lasso | 6 | 0.05 | 9.1e-04 | -4.8 | 6.9 | 4.7e-12 | -0.62 | 0.04 | 0.85 | FALSE |
| 3 | GTEx | Esophagus Mucosa | CSNK1G3 | 0.14 | 0.05 | lasso | 3 | 0.07 | 2.0e-05 | 6.4 | 6.5 | 1.0e-10 | -0.44 | 0.79 | 0.10 | FALSE |
| 4 | METSIM | Adipose | LOX | 0.11 | 0.06 | enet | 15 | 0.07 | 2.7e-10 | 5.7 | -5.2 | 1.6e-07 | 0.03 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CSNK1G3 | 0.04 | 0.02 | enet | 8 | 0.02 | 1.2e-04 | 6.5 | 8.1 | 6.8e-16 | -0.56 | 0.00 | 0.88 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | CEP120 | 0.06 | 0.02 | blup | 70 | 0.04 | 3.6e-03 | 5.4 | 7.1 | 9.7e-13 | -0.64 | 0.09 | 0.39 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CEP120 | 0.03 | 0.02 | enet | 5 | 0.04 | 7.3e-05 | -4.8 | 7.1 | 1.6e-12 | -0.66 | 0.03 | 0.82 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOX | 0.17 | 0.15 | blup | 35 | 0.17 | 6.8e-19 | 5.7 | 6.1 | 1.3e-09 | 0.08 | 0.00 | 1.00 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | CSNK1G3 | 0.06 | 0.05 | lasso | 2 | 0.04 | 2.0e-05 | 6.4 | 6.3 | 2.3e-10 | -0.44 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CEP120 | 0.10 | 0.14 | blup | 70 | 0.14 | 2.6e-14 | -10.0 | 9.0 | 1.8e-19 | -0.83 | 0.05 | 0.95 | TRUE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CSNK1G3 | 0.06 | 0.04 | enet | 10 | 0.05 | 2.3e-06 | 5.2 | 6.5 | 1.0e-10 | -0.57 | 0.10 | 0.88 | FALSE |