TWAS hub - LOX

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.1143	0.0423	0.0010	0.059	0.033	0.067	0.064	0.066	3.3e-09	8.7e-06	2.7e-10	6.5e-10	4.0e-10
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.1721	0.0526	0.0000	0.151	0.172	0.167	NA	0.166	1.1e-16	6.8e-19	2.3e-18	NA	2.7e-18
3	TCGA	Lung Adenocarcinoma	0.0185	0.0111	0.0042	0.008	0.023	0.009	NA	0.011	3.4e-02	9.2e-04	2.8e-02	NA	1.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Lung FEV1/FVC ratio	12.5	63.6	141.6	6.8	1.6	-11.9
Eye problems/disorders: Glaucoma	6.0	7.1	11.4	-3.0	3.4	-1.1
Medication: Ibuprofen (e.g. Nurofen)	5.0	6.4	10.3	-3.2	2.8	-1.1
Age at First Birth	4.4	6.4	9.7	2.3	-3.1	2.1
Medication: Seretide 50 evohaler	4.4	5.1	9.6	-2.2	-1.0	3.1
Medication: Ibuprofen	4.2	5.1	7.1	-2.7	2.4	-1.4
Neck or shoulder pain in last month	4.0	5.6	10.2	-3.2	2.3	-1.1
Breastfed as a baby	3.9	4.8	8.0	-2.8	2.4	-0.8
Emphysema/chronic bronchitis	3.9	4.4	5.9	-2.1	2.4	-1.7
Angina (self-reported)	3.7	4.9	7.2	-1.4	2.4	-2.7
Wears glasses or contact lenses	3.7	4.3	8.2	-0.7	2.9	-2.0
Glaucoma (self-reported)	3.2	3.7	5.9	-2.4	2.3	-0.4
Lung FVC	2.8	14.2	32.3	0.4	-3.2	5.7
Angina	2.8	3.7	5.4	-1.2	2.1	-2.3
Eye problems/disorders: None of the above	2.8	3.2	6.1	1.4	-2.5	1.3
Handedness (chirality/laterality): Left-handed	2.8	3.4	7.1	-1.2	2.7	-1.3
Crohns Disease (2012)	2.6	4.2	7.2	-1.3	2.7	-1.9
Osteoporosis (self-reported)	2.6	3.3	5.3	-2.3	2.1	-0.1
Ever had prostate specific antigen (PSA) test	2.6	3.0	4.9	-2.0	-0.4	2.2
Standing height	2.4	24.1	36.8	-5.2	6.1	-2.9
Comparative height size at age 10	2.4	13.4	19.6	-3.9	4.4	-2.4
Cholesterol lowering medication	2.4	3.5	7.7	-1.2	2.8	-1.2
LDL Cholesterol	2.3	3.6	6.2	2.5	0.4	-2.1
Stomach or abdominal pain in last month	2.2	2.7	4.5	1.9	-2.1	0.5
Medication: Co-codamol	2.1	2.4	5.9	-2.4	1.2	-0.0
Hair/balding pattern: Pattern 3	2.1	3.1	5.1	1.5	-2.2	1.4
Illnesses of mother	2.1	2.6	5.3	0.9	-1.3	2.3
Mother’s age at death	2.0	2.5	5.9	-2.4	0.8	1.0
Type 2 Diabetes (T2D) (2012)	1.9	2.2	4.2	0.7	1.4	-2.0
Commuting to job workplace: Walk	1.9	2.0	2.4	-1.1	1.6	-1.5
Major Depression (MDD)	1.8	2.2	5.7	-0.8	0.4	-2.4
Peak expiratory flow (PEF)	1.8	4.3	6.6	2.6	-0.3	-2.5
Height	1.7	32.6	51.4	-6.3	7.2	-2.6
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	3.3	-0.5	1.8	-1.8
Sitting height	1.7	12.2	20.2	-2.7	4.5	-3.0
Friendships satisfaction	1.7	2.1	3.6	1.6	-1.9	-0.5
Guilty feelings	1.7	2.5	4.7	1.2	-2.2	1.2
Alcohol drinker status: Previous	1.7	1.9	2.9	1.7	-0.3	-1.7
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	3.8	1.2	-2.0	0.7
Illnesses of father: Heart disease	1.6	2.2	4.0	0.1	1.6	-2.0
Breast cancer (self-reported)	1.6	1.9	4.2	2.0	-0.9	0.8
Systolic blood pressure, automated reading	1.5	4.3	9.8	-1.4	3.1	-1.0
Alcohol intake frequency.	1.5	3.5	8.6	1.1	0.7	-2.9
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	4.3	-1.0	2.1	-2.0
Medication: Lisinopril	1.5	2.0	3.5	-1.5	1.9	-0.5
Systolic Blood Pressure	1.4	7.0	13.2	-2.6	3.6	-1.1
Diabetes (father)	1.4	1.8	2.9	-1.7	0.1	1.6
Mouth/teeth dental problems: Dentures	1.4	2.4	5.3	-0.8	2.3	-1.1
Migraine (self-reported)	1.4	1.8	3.3	-1.8	1.4	0.5
Medication: Allopurinol	1.4	1.9	2.9	1.7	-1.7	0.2
Knee pain experienced in last month	1.4	2.1	3.2	1.0	1.5	-1.8
Medication for cholesterol	1.4	2.1	2.5	1.2	-1.5	1.6
Primary Biliary Cirrhosis	1.3	1.8	2.6	0.5	1.6	-1.6
Taking other prescription medications	1.3	2.1	3.5	-1.9	1.3	1.0
Trunk fat-free mass	1.3	7.4	13.8	-2.6	3.7	-1.2
Happiness	1.3	1.6	2.7	1.7	-1.4	0.3
Trunk predicted mass	1.3	7.5	13.9	-2.6	3.7	-1.3
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.2	-1.4	1.8	-0.2
Exposure to tobacco smoke outside home	1.3	1.8	4.1	-0.3	1.1	-2.0
Number of children fathered	1.3	1.4	2.4	-1.0	1.5	-0.9
Number of self-reported non-cancer illnesses	1.3	2.3	4.3	-2.1	1.6	0.0
Heart disease (siblings)	1.3	1.5	3.8	0.9	0.1	-2.0
Crohns Disease (2017)	1.2	2.7	4.6	-1.0	2.1	-1.6
Waist Hip Ratio (WHR)	1.2	5.3	10.8	-0.8	2.1	-3.3
Relative age voice broke	1.2	1.9	3.9	1.2	0.4	-2.0
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	3.8	0.7	-1.9	0.3
Hair/balding pattern: Pattern 2	1.2	1.6	3.3	0.8	-0.8	1.8
Arm fat-free mass (right)	1.2	6.1	11.5	-2.1	3.4	-1.6
Whole body water mass	1.2	7.0	13.6	-2.5	3.7	-1.2
Ever taken oral contraceptive pill	1.2	1.3	2.1	0.0	-1.5	1.3
Alcohol drinker status: Never	1.2	1.5	2.4	1.6	-0.3	-1.4
Arm fat-free mass (left)	1.2	6.0	12.1	-1.8	3.5	-1.6
Risk taking	1.2	1.8	3.2	1.8	-1.2	-0.8
Arm predicted mass (left)	1.2	6.0	11.8	-2.0	3.4	-1.4
Bipolar Disorder (2018)	1.1	1.7	3.0	-1.7	1.5	0.2
Fasting Glucose	1.1	1.3	2.4	-1.5	0.8	-1.0
Neuroticism (2016)	1.1	1.7	3.4	-1.0	-0.8	1.8
Ever used hormone-replacement therapy (HRT)	1.1	1.4	1.7	-1.1	1.1	-1.3
Leg fat-free mass (left)	1.1	5.6	10.6	-2.3	3.2	-0.9
Pain all over the body in last month	1.1	1.1	2.3	-0.0	1.0	-1.5
Illnesses of siblings	1.1	1.5	2.7	-1.3	-0.2	1.7
Number of live births	1.1	1.6	3.3	-0.3	1.2	-1.8
Headache pain in last month	1.1	1.9	4.3	-2.1	0.4	1.0
Arm predicted mass (right)	1.1	5.4	10.5	-2.0	3.2	-1.3
Suffer from ‘nerves’	1.1	1.7	3.0	-0.3	-1.4	1.7
Leg pain on walking	1.1	1.3	2.3	-0.2	1.3	-1.5
Whole body fat-free mass	1.1	6.5	12.5	-2.4	3.5	-1.1
Leg fat-free mass (right)	1.1	5.8	11.1	-2.2	3.3	-1.1
Leg predicted mass (right)	1.1	6.0	11.4	-2.3	3.4	-1.2
Hearing aid user	1.1	1.2	1.9	-0.5	1.2	-1.4
Basal metabolic rate	1.1	5.8	11.7	-2.1	3.4	-1.1
Irritable Bowel Disease (IBD)	1.0	2.4	3.5	-1.4	1.9	-1.4
Sensitivity / hurt feelings	1.0	1.7	3.0	-0.2	-1.4	1.7
High blood pressure	1.0	2.7	5.8	-2.4	1.6	-0.1
Multivitamins +/- minerals	1.0	1.3	1.8	1.3	-1.3	0.5
Leg predicted mass (left)	1.0	5.5	10.5	-2.3	3.2	-0.9
Worrier / anxious feelings	1.0	1.9	2.9	-1.7	0.1	1.7
Birth weight of first child	1.0	1.7	4.5	0.2	-0.8	2.1
Gout (self-reported)	1.0	1.3	2.0	1.4	-1.4	0.0
Health satisfaction	1.0	1.3	2.1	-0.7	1.2	-1.5
Mean time to correctly identify matches	1.0	2.0	3.0	-1.7	1.3	-1.1
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.2	0.1	-1.1	1.5
Hypertension (Self-reported)	1.0	2.8	5.6	-2.4	1.7	0.0
Mood swings	1.0	1.8	2.8	1.0	-1.3	1.7
Commuting to job workplace: Public transport	1.0	1.2	2.3	-0.8	1.5	-0.8
Medication: Blood pressure	1.0	2.0	5.2	-2.3	0.8	-0.1
Vascular/heart problems diagnosed by doctor	1.0	2.9	6.1	2.5	-1.6	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.1	0.3	-1.2	1.4
Coronary Artery Disease (CAD)	0.9	1.1	1.8	-0.2	1.3	-1.2
Respiratory disease	0.9	1.9	5.1	-2.2	0.8	0.2
Ever had hysterectomy (womb removed)	0.9	1.0	1.7	-1.3	1.2	0.1
Fed-up feelings	0.9	1.7	4.0	2.0	-0.7	-0.7
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.7	0.8	0.1	-1.6
Medication: Ramipril	0.9	1.2	1.8	-1.1	1.3	-0.8
Falls in the last year	0.9	1.3	1.5	1.2	-1.2	-0.9
High blood pressure (siblings)	0.9	1.3	3.3	0.7	-0.1	-1.8
Overall health rating	0.9	2.0	2.9	-1.2	1.7	-1.2
Pain experienced in last month	0.9	1.5	1.8	1.3	-1.2	1.1
Neuroticism (Nagel 2018)	0.8	1.8	2.8	0.4	-1.7	1.5
Cardiovascular Disease	0.8	2.5	3.9	-1.8	2.0	-0.6
Severe depression (siblings)	0.8	0.9	1.4	-1.2	1.1	-0.4
Serious illness, injury or assault to yourself	0.8	0.9	1.8	0.5	-0.8	1.4
Supplements: Glucosamine	0.8	1.0	1.7	1.3	-0.8	-0.9
High blood pressure (mother)	0.8	1.1	2.3	-0.8	0.5	-1.5
Financial difficulties in last 2 years	0.8	1.0	1.6	-0.1	1.2	-1.2
Medication: Simvastatin	0.8	1.2	1.9	0.2	1.3	-1.4
Time employed in main current job	0.8	1.0	2.4	1.6	-0.6	0.3
Alcohol intake versus 10 years previously	0.8	1.2	1.7	1.2	-0.6	-1.3
Blood clot in the leg (DVT)	0.8	1.1	2.3	-0.9	1.5	-0.4
Birth weight	0.8	1.7	3.4	-1.2	0.5	1.8
Forced vital capacity (FVC), Best measure	0.8	2.8	6.1	-2.5	0.9	1.3
Number of full brothers	0.8	1.0	2.3	-1.5	0.8	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.9	1.4	-0.1	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.3	-0.7	1.5	-0.4
Heel T-Score	0.7	5.8	11.2	-3.4	2.1	1.3
Neuroticism	0.7	1.7	3.0	-0.1	-1.7	1.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.6	-1.3	0.4	0.7
Age when periods started (menarche)	0.7	1.6	4.4	-2.1	0.4	0.6
Medication: Atenolol	0.7	0.9	1.7	-1.3	0.7	-0.6
Weight	0.7	3.2	7.1	-1.5	2.7	-0.6
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.6	0.8	-1.2	1.6
Prospective memory result	0.7	0.9	2.6	-0.1	-0.2	1.6
Hair/balding pattern: Pattern 4	0.7	1.6	3.3	1.8	-1.0	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.8	-0.1	-0.7	1.3
Medication: Blood pressure	0.7	1.3	2.0	-1.0	1.4	-0.9
Medication: Omeprazole	0.7	0.9	1.8	-0.2	-0.8	1.4
Osteoarthritis (self-reported)	0.7	0.9	1.4	-0.8	1.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	2.0	0.9	1.4	-1.4
Medication: Atorvastatin	0.7	0.9	2.1	-1.4	0.7	-0.3
Number of operations (self-reported)	0.7	1.0	2.1	-0.3	0.9	-1.4
Vitamin and mineral supplements	0.6	0.8	1.8	-0.8	1.4	-0.1
Supplements: Zinc	0.6	0.6	0.9	-0.7	-0.7	1.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.0	-1.4	0.0	-0.1
Forced vital capacity (FVC)	0.6	2.4	4.9	-2.2	0.7	1.4
Lung cancer (father)	0.6	0.7	1.1	-0.8	0.5	1.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.3	1.1	-0.9	-0.2
Loud music exposure frequency	0.6	0.6	1.8	-1.3	0.2	0.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.6	-1.3	0.8	0.1
Qualifications: College or University degree	0.6	2.0	3.2	1.8	-1.5	0.6
Average weekly champagne plus white wine intake	0.6	0.8	1.7	-0.5	-0.6	1.3
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.5	-1.2	0.9	0.2
Irritability	0.6	1.0	1.9	0.7	-1.4	0.8
Depressed Affect (Nagel 2018)	0.5	1.1	1.8	1.0	-1.4	0.7
Schizophrenia vs Biploar Disorder	0.5	0.7	0.9	1.0	-0.9	0.4
Worry (Nagel 2018)	0.5	1.0	1.7	-1.0	-0.5	1.3
Reaction Time	0.5	1.0	1.8	-1.0	0.5	-1.3
Breast Cancer	0.5	1.3	3.6	1.9	-0.5	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	0.9	-0.6	1.0	-0.9
Triglycerides	0.5	0.7	1.4	0.1	1.2	-0.9
Average weekly spirits intake	0.5	0.6	1.5	-0.1	-0.5	1.2
Hearing difficulty/problems: Yes	0.5	0.8	1.6	-0.5	1.3	-0.8
Relative age of first facial hair	0.5	1.0	2.0	1.0	-1.4	0.2
Medication for hormone replacement therapy	0.5	0.5	0.9	0.8	-1.0	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.7	-1.3	0.4	1.2
Alcohol usually taken with meals	0.5	0.9	1.5	-0.8	-1.2	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.8	-1.3	0.7	1.0
Heart attack	0.5	0.7	1.6	0.4	0.4	-1.3
Neuroticism score	0.5	1.1	1.9	0.0	-1.2	1.4
Hip circumference	0.5	2.3	5.5	-1.0	2.4	-0.7
Medication: Paracetamol	0.5	0.9	1.4	-1.2	-0.3	1.1
Comparative body size at age 10	0.5	1.4	1.8	1.2	-1.0	1.3
Worry too long after embarrassment	0.5	0.8	1.5	-1.2	0.3	1.0
Shortness of breath walking on level ground	0.5	0.6	0.8	0.9	0.5	-0.8
Medication for pain relief, constipation, heartburn	0.5	0.8	1.2	1.1	-0.5	-0.9
Chest pain or discomfort	0.5	0.7	1.1	0.7	0.7	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.8	-1.3	-0.0	-0.1
Loneliness, isolation	0.5	0.7	1.0	1.0	-0.8	0.6
Age started oral contraceptive pill	0.5	0.6	1.5	-0.5	0.1	1.2
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.7	0.4	0.4	-1.3
Alzheimer’s Disease (including proxy)	0.4	0.5	1.0	0.6	-1.0	0.5
Waist circumference	0.4	1.5	3.2	-0.1	1.8	-1.1
Had menopause	0.4	0.5	1.6	-1.3	0.2	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.8	0.3	0.9	-0.9
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.0	0.6	-1.0	0.6
Wheeze or whistling in the chest in last year	0.4	0.8	0.9	-0.8	0.9	-0.9
Age at first live birth	0.4	0.7	1.7	-0.4	-0.4	1.3
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.9	1.0	-0.1	0.6
Heart disease (mother)	0.4	0.5	1.0	-0.3	1.0	-0.6
Average weekly red wine intake	0.4	0.6	0.9	-1.0	0.8	-0.5
Eye problems/disorders: Cataract	0.4	0.5	0.8	-0.8	0.9	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.2	0.1	-0.5	1.1
Mineral and other dietary supplements	0.4	0.5	0.9	-0.8	-0.2	0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	0.8	-0.1	-0.9	0.9
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.9	-1.0	0.3	0.6
Medication: Bendroflumethiazide	0.4	0.7	1.4	0.8	0.0	-1.2
Medication: Paracetamol	0.4	0.6	1.1	-1.1	-0.2	0.9
Myopia	0.4	0.6	1.5	-0.5	0.4	1.2
Depression (Nagel 2018)	0.3	0.5	0.9	0.8	0.0	-1.0
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.9	-0.1	-0.1	1.7
Schizophrenia (2018)	0.3	0.6	1.4	0.6	-1.2	-0.1
Alzheimer’s Disease (in mother)	0.3	0.4	0.6	-0.7	-0.8	0.4
Ulcerative Colitis (UC)	0.3	0.6	0.7	-0.8	0.7	-0.8
Prostate Cancer	0.3	0.4	1.0	-0.4	-0.2	1.0
Lupus	0.3	0.5	1.2	1.1	0.4	-0.1
Rheumatoid Arthritis	0.3	0.4	1.3	-0.1	0.1	1.1
Number of treatments/medications taken	0.3	0.6	0.9	-1.0	0.0	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	0.8	0.7	-0.3
Medication: Levothyroxine sodium	0.3	0.6	0.9	-1.0	0.8	0.4
Chronic bronchitis/emphysema (father)	0.3	0.4	0.9	0.4	1.0	0.2
Number of incorrect matches in round	0.3	0.5	0.8	-0.8	0.9	-0.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.7	0.5	0.4	-1.6
Pulse rate	0.3	0.6	1.6	0.2	0.2	-1.3
Noisy workplace	0.3	0.3	0.7	-0.8	0.4	-0.4
Medication: Cholesterol lowering	0.3	0.5	1.4	0.0	0.5	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.6	0.3	0.6	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.0	0.3	-1.0	0.4
Pulse wave reflection index	0.3	0.3	0.7	-0.4	-0.1	0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.7	0.7	0.4	-0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.6	-0.1	-0.2	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.5	0.7	-0.7	0.1
Pulse rate, automated reading	0.3	1.1	2.8	0.1	0.6	-1.7
Number of full sisters	0.3	0.4	0.9	0.3	-0.3	-1.0
Supplements: Vitamin C	0.3	0.4	1.0	-1.0	-0.2	0.1
Long-standing illness, disability or infirmity	0.3	0.5	0.7	-0.7	0.8	0.3
Back pain experienced in last month	0.3	0.4	1.1	-0.1	0.2	-1.1
Financial situation satisfaction	0.3	0.4	0.4	-0.5	0.6	-0.6
High cholesterol (Self-reported)	0.3	0.5	1.0	-0.5	1.0	-0.4
Illnesses of father: High blood pressure	0.3	0.4	0.9	-1.0	0.5	-0.0
Fractured/broken bones in last 5 years	0.3	0.4	0.9	-0.6	-0.2	0.9
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.5	-0.2	0.6
Ovarian Cancer	0.2	0.3	0.6	0.1	-0.4	-0.7
Bipolar Disorder (2011)	0.2	0.1	0.4	0.7	0.1	-0.1
Mean Putamen Volume	0.2	0.2	0.4	0.6	-0.6	-0.1
HbA1C	0.2	0.2	0.5	-0.3	-0.7	0.1
HDL Cholesterol	0.2	0.3	0.5	-0.7	0.6	0.1
Schizophrenia (2014)	0.2	0.5	1.3	0.4	-0.3	-1.2
Smoking Status	0.2	0.4	0.6	-0.8	0.8	-0.1
Hypothyroidism (self reported)	0.2	0.6	1.3	-0.5	0.4	1.1
Tanning	0.2	2.6	4.5	0.1	-1.8	2.1
Diabetes (mother)	0.2	0.2	0.3	-0.5	0.4	-0.6
Hand grip strength (right)	0.2	0.6	1.2	-0.8	-0.3	1.1
Current tobacco smoking	0.2	0.3	0.5	-0.3	0.5	-0.7
Average weekly fortified wine intake	0.2	0.2	0.3	0.5	-0.4	-0.6
Impedance of leg (left)	0.2	1.1	1.7	1.0	-0.8	-1.3
Trunk fat mass	0.2	0.9	2.3	-0.5	1.5	-0.1
Nervous feelings	0.2	0.4	0.6	-0.8	0.3	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.9	-0.9	-0.0	0.5
Qualifications: None of the above	0.2	0.5	0.8	-0.3	0.9	-0.7
Mouth/teeth dental problems	0.2	0.3	0.7	0.4	-0.8	-0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	0.5	-0.1	-0.6
Arm fat percentage (right)	0.2	0.8	1.2	1.1	-0.1	1.0
Asthma	0.2	0.4	1.1	-1.1	0.1	0.1
Medication: Lansoprazole	0.2	0.2	0.4	0.4	0.2	-0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.1	0.6	-0.6
Length of working week for main job	0.2	0.2	0.5	0.3	-0.7	-0.1
Tense / ‘highly strung’	0.2	0.4	0.8	0.4	-0.5	0.9
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.4	0.6	-0.0
Whole body fat mass	0.2	0.7	1.9	-0.2	1.4	-0.3
Age at last live birth	0.2	0.3	0.6	0.4	-0.8	0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	0.5	-0.2	-0.6
Arm fat percentage (left)	0.2	0.8	1.2	1.1	-0.3	1.1
Ever had bowel cancer screening	0.2	0.2	0.4	-0.6	0.5	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	0.4	-0.5	0.7
Miserableness	0.2	0.4	0.5	0.5	-0.6	0.7
Leg fat percentage (left)	0.2	0.7	2.2	1.5	-0.1	-0.2
Diastolic blood pressure, automated reading	0.2	0.6	1.2	-0.5	0.6	1.1
Ever depressed for a whole week	0.2	0.2	0.7	-0.1	-0.2	-0.8
Commuting to job workplace: Cycle	0.2	0.2	0.3	0.1	0.5	-0.6
Supplements: Calcium	0.2	0.2	0.4	0.6	-0.5	-0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.7	0.9	-0.4	0.2
Ulcerative Colitis	0.1	0.2	0.3	-0.6	0.2	-0.5
Blood White Count	0.1	0.7	1.1	0.4	0.8	-1.1
BMI	0.1	0.3	1.0	-0.1	1.0	0.2
Allergy or Eczema	0.1	0.3	0.8	-0.1	-0.9	-0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	-0.0	-0.3	-0.6
Chronotype (morning person)	0.1	0.3	0.5	-0.6	0.7	-0.1
Hair Pigment	0.1	1.9	5.4	-0.5	-0.2	2.3
Medication: Metformin	0.1	0.1	0.1	0.4	-0.3	-0.2
Pack years adult smoking proportion	0.1	0.2	0.5	0.4	0.1	-0.7
Impedance of leg (right)	0.1	0.6	0.9	0.6	-1.0	-0.6
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.5	-0.3	-0.3
Maternal smoking around birth	0.1	0.1	0.1	0.4	-0.1	0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.4	0.4	-0.3
Body mass index (BMI)	0.1	0.5	1.0	1.0	-0.1	0.7
Past tobacco smoking	0.1	0.1	0.3	-0.6	0.2	0.2
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.2	0.2	-0.5
Had other major operations	0.1	0.1	0.1	0.1	-0.3	-0.3
Allergy	0.1	0.1	0.2	0.3	-0.4	0.4
Diabetes (self-reported)	0.1	0.1	0.3	-0.6	0.1	-0.1
Father’s age at death	0.1	0.1	0.3	0.3	-0.5	0.1
Depression (self-reported)	0.1	0.1	0.1	0.3	0.3	-0.2
Impedance of arm (left)	0.1	0.3	0.8	0.2	-0.9	0.1
Arm fat mass (right)	0.1	0.4	1.0	0.2	1.0	0.2
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.1	-0.3	0.5
Body fat percentage	0.1	0.3	0.6	0.8	0.3	0.3
Leg fat percentage (right)	0.1	0.5	1.4	1.2	-0.1	0.4
Pulse wave peak to peak time	0.1	0.1	0.3	-0.5	-0.1	0.4
Leg fat mass (right)	0.1	0.4	1.1	-0.0	1.1	0.1
Had major operations	0.1	0.1	0.2	0.3	0.3	0.5
Family relationship satisfaction	0.1	0.1	0.1	0.4	0.0	-0.4
Medication: Aspirin	0.1	0.1	0.3	0.0	0.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.5	0.1	0.3
Illnesses of siblings: Diabetes	0.1	0.2	0.4	0.3	0.2	-0.6
Smoking status: Previous	0.1	0.1	0.1	-0.1	0.4	-0.3
Diabetes diagnosed by doctor	0.1	0.1	0.1	-0.3	-0.3	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.1	-0.6	-0.3
Qualifications: nursing, teaching	0.1	0.2	0.6	0.8	0.1	-0.0
Asthma (self-reported)	0.1	0.3	0.8	-0.9	0.0	0.1
Medication: Aspirin	0.1	0.1	0.3	0.1	0.5	-0.4
Medication: Gliclazide	0.1	0.1	0.2	0.4	-0.3	0.2
Smoking status: Current	0.1	0.1	0.4	0.2	0.2	-0.6
Arm fat mass (left)	0.1	0.3	0.8	0.3	0.9	0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.1	0.3	-0.3
Average weekly beer plus cider intake	0.1	0.1	0.2	0.5	-0.2	-0.4
Unable to work because of sickness or disability	0.1	0.1	0.3	0.2	-0.3	-0.5
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.4	0.1	-0.4
Impedance of whole body	0.1	0.6	0.8	0.7	-0.9	-0.7
Leg fat mass (left)	0.1	0.4	1.0	0.3	1.0	-0.4
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	-0.5	-0.0	0.0
Blood Eosinophil Count	0.0	0.1	0.4	-0.6	0.0	-0.2
Blood Platelet Count	0.0	0.3	0.9	0.9	0.2	-0.1
Blood Red Count	0.0	0.2	0.4	-0.6	0.6	0.1
Hand grip strength (left)	0.0	0.1	0.2	-0.0	0.1	0.4
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.2	0.1	0.4	-0.1
Trunk fat percentage	0.0	0.2	0.2	0.3	0.4	0.4
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.3	-0.5	0.0	0.1
Fluid intelligence score	0.0	0.0	0.1	0.1	-0.2	-0.3
Impedance of arm (right)	0.0	0.1	0.1	-0.1	-0.2	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.0	-0.1	0.2
Medication: Amlodipine	0.0	0.0	0.0	0.2	-0.0	0.0
Ever smoked	0.0	0.0	0.1	0.2	0.0	-0.1
Pack years of smoking	0.0	0.0	0.0	-0.1	0.1	-0.1

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