Best TWAS P=8.6e-21 · Best GWAS P=1.27e-43 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CAMLG | 0.39 | 0.35 | lasso | 6 | 0.34 | 1.8e-42 | -8.29 | -8.3 | 1.2e-16 | 0.26 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SAR1B | 0.12 | 0.06 | lasso | 6 | 0.09 | 8.1e-11 | -7.69 | -6.9 | 4.6e-12 | 0.22 | 0.99 | 0.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | CAMLG | 0.15 | 0.11 | lasso | 1 | 0.10 | 1.0e-05 | -8.10 | -8.1 | 5.5e-16 | 0.24 | 0.48 | 0.03 | FALSE |
| 4 | GTEx | Artery Aorta | TXNDC15 | 0.16 | 0.14 | lasso | 2 | 0.12 | 2.2e-07 | 5.93 | 5.9 | 2.9e-09 | -0.25 | 0.98 | 0.00 | TRUE |
| 5 | GTEx | Artery Aorta | CAMLG | 0.22 | 0.17 | lasso | 3 | 0.12 | 2.2e-07 | -8.30 | -8.6 | 6.0e-18 | 0.27 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Artery Coronary | CAMLG | 0.27 | 0.20 | lasso | 8 | 0.12 | 5.3e-05 | -8.09 | -8.3 | 6.9e-17 | 0.24 | 0.85 | 0.01 | FALSE |
| 7 | GTEx | Artery Tibial | CAMLG | 0.11 | 0.11 | lasso | 1 | 0.09 | 9.1e-08 | -8.30 | -8.3 | 1.0e-16 | 0.26 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Brain Cerebellar Hemisphere | TXNDC15 | 0.51 | 0.48 | lasso | 5 | 0.47 | 1.2e-13 | -8.04 | -8.2 | 1.7e-16 | 0.26 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Brain Cerebellar Hemisphere | CAMLG | 0.42 | 0.24 | lasso | 8 | 0.20 | 8.8e-06 | -8.09 | -8.5 | 2.2e-17 | 0.26 | 0.75 | 0.02 | FALSE |
| 10 | GTEx | Brain Cerebellum | TXNDC15 | 0.48 | 0.36 | lasso | 4 | 0.48 | 5.7e-16 | -8.04 | -8.0 | 9.1e-16 | 0.26 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Brain Cerebellum | CAMLG | 0.31 | 0.27 | lasso | 13 | 0.24 | 7.5e-08 | -8.10 | -8.3 | 1.0e-16 | 0.25 | 0.96 | 0.00 | FALSE |
| 12 | GTEx | Brain Cortex | CAMLG | 0.23 | 0.28 | lasso | 10 | 0.26 | 1.1e-07 | -8.10 | -8.1 | 5.8e-16 | 0.24 | 0.73 | 0.02 | FALSE |
| 13 | GTEx | Brain Frontal Cortex BA9 | CAMLG | 0.36 | 0.30 | lasso | 5 | 0.26 | 1.2e-07 | -8.30 | -8.7 | 3.3e-18 | 0.30 | 0.92 | 0.01 | FALSE |
| 14 | GTEx | Brain Hypothalamus | CAMLG | 0.28 | 0.28 | lasso | 4 | 0.25 | 1.3e-06 | -8.10 | -8.1 | 4.7e-16 | 0.24 | 0.67 | 0.02 | FALSE |
| 15 | GTEx | Brain Nucleus accumbens basal ganglia | CAMLG | 0.29 | 0.25 | enet | 8 | 0.32 | 2.3e-09 | -8.29 | -8.7 | 4.6e-18 | 0.27 | 0.97 | 0.00 | FALSE |
| 16 | GTEx | Brain Putamen basal ganglia | TXNDC15 | 0.39 | -0.01 | enet | 22 | 0.06 | 1.6e-02 | -0.32 | -7.9 | 2.3e-15 | 0.44 | 0.03 | 0.41 | TRUE |
| 17 | GTEx | Breast Mammary Tissue (Female) | CDKN2AIPNL | 0.25 | 0.05 | enet | 28 | 0.06 | 7.2e-03 | 3.19 | 5.8 | 7.4e-09 | -0.21 | 0.04 | 0.14 | TRUE |
| 18 | GTEx | Cells EBV-transformed lymphocytes | PHF15 | 0.26 | 0.18 | lasso | 6 | 0.22 | 7.1e-08 | 7.71 | 8.6 | 6.6e-18 | -0.20 | 0.71 | 0.03 | FALSE |
| 19 | GTEx | Cells Transformed fibroblasts | TXNDC15 | 0.38 | 0.31 | lasso | 11 | 0.33 | 4.8e-25 | -8.33 | 9.1 | 1.1e-19 | -0.30 | 1.00 | 0.00 | FALSE |
| 20 | GTEx | Colon Sigmoid | TXNDC15 | 0.19 | 0.12 | lasso | 6 | 0.10 | 1.6e-04 | -7.22 | -8.2 | 3.1e-16 | 0.25 | 0.49 | 0.03 | FALSE |
| 21 | GTEx | Colon Sigmoid | CAMLG | 0.16 | 0.01 | lasso | 3 | 0.00 | 2.9e-01 | -8.09 | -7.5 | 6.7e-14 | 0.21 | 0.10 | 0.05 | FALSE |
| 22 | GTEx | Colon Transverse | TXNDC15 | 0.22 | -0.01 | lasso | 7 | -0.01 | 6.8e-01 | -8.04 | -8.2 | 2.6e-16 | 0.25 | 0.10 | 0.05 | FALSE |
| 23 | GTEx | Colon Transverse | SAR1B | 0.11 | 0.00 | enet | 17 | 0.03 | 1.2e-02 | -7.22 | -6.4 | 1.6e-10 | 0.17 | 0.07 | 0.04 | FALSE |
| 24 | GTEx | Esophagus Muscularis | CAMLG | 0.23 | 0.17 | lasso | 5 | 0.15 | 1.3e-09 | -8.09 | -8.1 | 6.2e-16 | 0.22 | 1.00 | 0.00 | FALSE |
| 25 | GTEx | Heart Atrial Appendage | CAMLG | 0.14 | 0.03 | lasso | 4 | 0.03 | 2.0e-02 | -8.29 | -7.7 | 1.4e-14 | 0.21 | 0.28 | 0.04 | FALSE |
| 26 | GTEx | Lung | CAMLG | 0.11 | 0.11 | enet | 7 | 0.11 | 9.1e-09 | -8.30 | -8.7 | 2.5e-18 | 0.26 | 1.00 | 0.00 | FALSE |
| 27 | GTEx | Muscle Skeletal | SAR1B | 0.10 | 0.04 | lasso | 7 | 0.04 | 6.1e-05 | 3.47 | -6.6 | 3.7e-11 | 0.24 | 0.23 | 0.14 | FALSE |
| 28 | GTEx | Muscle Skeletal | CAMLG | 0.08 | 0.01 | enet | 28 | 0.05 | 2.0e-05 | -0.26 | -6.9 | 5.5e-12 | -0.05 | 0.05 | 0.04 | FALSE |
| 29 | GTEx | Nerve Tibial | TXNDC15 | 0.26 | 0.17 | lasso | 5 | 0.20 | 6.9e-14 | -8.04 | -6.2 | 6.1e-10 | 0.17 | 1.00 | 0.00 | FALSE |
| 30 | GTEx | Nerve Tibial | CAMLG | 0.25 | 0.19 | lasso | 5 | 0.19 | 1.5e-13 | -8.35 | -8.3 | 9.9e-17 | 0.25 | 1.00 | 0.00 | FALSE |
| 31 | GTEx | Pituitary | TXNDC15 | 0.32 | 0.18 | lasso | 6 | 0.23 | 1.9e-06 | -8.04 | -7.3 | 2.3e-13 | 0.25 | 0.50 | 0.05 | FALSE |
| 32 | GTEx | Pituitary | CAMLG | 0.20 | 0.07 | enet | 10 | 0.09 | 3.3e-03 | -8.10 | -8.3 | 1.4e-16 | 0.24 | 0.50 | 0.03 | FALSE |
| 33 | GTEx | Skin Not Sun Exposed Suprapubic | TXNDC15 | 0.19 | 0.16 | enet | 16 | 0.11 | 8.6e-07 | -8.04 | -5.6 | 2.8e-08 | 0.13 | 1.00 | 0.00 | FALSE |
| 34 | GTEx | Skin Sun Exposed Lower leg | TXNDC15 | 0.14 | 0.09 | lasso | 2 | 0.17 | 5.3e-14 | -8.04 | -5.3 | 9.1e-08 | 0.14 | 1.00 | 0.00 | FALSE |
| 35 | GTEx | Skin Sun Exposed Lower leg | CAMLG | 0.11 | 0.05 | lasso | 2 | 0.03 | 2.9e-03 | -8.10 | -8.2 | 2.0e-16 | 0.22 | 0.55 | 0.10 | FALSE |
| 36 | GTEx | Spleen | CAMLG | 0.27 | 0.07 | lasso | 7 | 0.10 | 1.4e-03 | -8.04 | -7.4 | 1.1e-13 | 0.20 | 0.06 | 0.37 | FALSE |
| 37 | GTEx | Thyroid | TXNDC15 | 0.24 | 0.22 | enet | 8 | 0.24 | 3.0e-18 | -8.33 | -7.2 | 5.4e-13 | 0.21 | 1.00 | 0.00 | FALSE |
| 38 | GTEx | Thyroid | CAMLG | 0.21 | 0.21 | lasso | 5 | 0.21 | 3.3e-16 | -8.10 | -8.3 | 1.6e-16 | 0.25 | 1.00 | 0.00 | FALSE |
| 39 | METSIM | Adipose | CAMLG | 0.14 | 0.18 | enet | 8 | 0.21 | 4.0e-30 | -8.30 | -8.3 | 1.3e-16 | 0.26 | 1.00 | 0.00 | FALSE |
| 40 | METSIM | Adipose | SAR1B | 0.06 | 0.02 | bslmm | 288 | 0.03 | 3.1e-05 | -8.29 | -9.4 | 8.6e-21 | 0.15 | 0.54 | 0.02 | TRUE |
| 41 | NTR | Blood | TXNDC15 | 0.05 | 0.05 | lasso | 2 | 0.05 | 2.7e-15 | -8.04 | -7.9 | 3.6e-15 | 0.25 | 1.00 | 0.00 | FALSE |
| 42 | ROSMAP | Brain Pre-frontal Cortex | TXNDC15 | 0.19 | 0.10 | bslmm | 324 | 0.14 | 1.2e-17 | -8.04 | -7.5 | 5.5e-14 | 0.31 | 1.00 | 0.00 | FALSE |
| 43 | ROSMAP | Brain Pre-frontal Cortex | CAMLG | 0.47 | 0.52 | lasso | 8 | 0.52 | 2.2e-79 | -8.29 | -8.3 | 1.0e-16 | 0.26 | 1.00 | 0.00 | FALSE |
| 44 | YFS | Blood | CAMLG | 0.12 | 0.19 | bslmm | 295 | 0.20 | 1.2e-61 | -8.30 | -8.5 | 1.6e-17 | 0.27 | 1.00 | 0.00 | FALSE |
| 45 | YFS | Blood | TXNDC15 | 0.09 | 0.05 | lasso | 8 | 0.11 | 7.0e-33 | -8.31 | -7.3 | 2.2e-13 | 0.24 | 1.00 | 0.00 | TRUE |
| 46 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CAMLG | 0.10 | 0.04 | blup | 17 | 0.04 | 2.2e-04 | -8.29 | -7.2 | 6.4e-13 | 0.26 | 0.00 | 0.96 | FALSE |
| 47 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TXNDC15 | 0.05 | 0.06 | lasso | 3 | 0.06 | 1.9e-11 | -8.30 | 8.5 | 2.2e-17 | -0.26 | 0.01 | 0.99 | FALSE |
| 48 | The Cancer Genome Atlas | Colon Adenocarcinoma | TXNDC15 | 0.13 | 0.08 | blup | 43 | 0.09 | 9.7e-06 | -8.30 | 8.1 | 5.0e-16 | -0.29 | 0.01 | 0.99 | TRUE |
| 49 | The Cancer Genome Atlas | Glioblastoma Multiforme | CAMLG | 0.29 | 0.18 | lasso | 3 | 0.13 | 9.6e-05 | -8.29 | -8.5 | 2.1e-17 | 0.28 | 0.00 | 0.99 | FALSE |
| 50 | The Cancer Genome Atlas | Glioblastoma Multiforme | TXNDC15 | 0.27 | 0.07 | lasso | 2 | 0.11 | 3.2e-04 | -8.04 | 8.2 | 3.2e-16 | -0.26 | 0.01 | 0.84 | FALSE |
| 51 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TXNDC15 | 0.05 | 0.04 | lasso | 1 | 0.03 | 4.8e-04 | -8.04 | 8.0 | 9.4e-16 | -0.25 | 0.01 | 0.94 | FALSE |
| 52 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SAR1B | 0.03 | 0.00 | blup | 27 | 0.01 | 2.6e-02 | 7.79 | -8.8 | 1.4e-18 | 0.27 | 0.01 | 0.30 | FALSE |
| 53 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TXNDC15 | 0.10 | 0.05 | blup | 41 | 0.05 | 2.4e-06 | -8.04 | 6.1 | 8.5e-10 | -0.15 | 0.01 | 0.99 | TRUE |
| 54 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SAR1B | 0.15 | 0.04 | enet | 10 | 0.05 | 1.3e-03 | 4.66 | -5.2 | 2.6e-07 | 0.16 | 0.02 | 0.08 | TRUE |
| 55 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CAMLG | 0.08 | 0.05 | lasso | 1 | 0.04 | 1.8e-05 | -8.29 | -8.3 | 1.2e-16 | 0.27 | 0.00 | 1.00 | TRUE |
| 56 | The Cancer Genome Atlas | Lung Adenocarcinoma | TXNDC15 | 0.05 | 0.05 | lasso | 1 | 0.04 | 1.0e-05 | -8.33 | 8.3 | 8.0e-17 | -0.25 | 0.01 | 0.99 | FALSE |
| 57 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TXNDC15 | 0.03 | 0.03 | blup | 35 | 0.03 | 5.6e-04 | -8.04 | 9.0 | 2.3e-19 | -0.28 | 0.01 | 0.93 | FALSE |
| 58 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TXNDC15 | 0.23 | 0.21 | enet | 10 | 0.20 | 1.1e-08 | -8.33 | 9.0 | 3.5e-19 | -0.28 | 0.00 | 1.00 | FALSE |
| 59 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CAMLG | 0.13 | 0.07 | lasso | 3 | 0.05 | 2.0e-06 | -8.29 | -8.6 | 6.0e-18 | 0.28 | 0.00 | 1.00 | FALSE |
| 60 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SAR1B | 0.04 | 0.01 | enet | 4 | 0.02 | 2.5e-03 | 6.50 | -6.9 | 5.1e-12 | 0.16 | 0.03 | 0.09 | FALSE |
| 61 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TXNDC15 | 0.07 | 0.04 | lasso | 4 | 0.04 | 6.2e-05 | -8.04 | 8.2 | 2.7e-16 | -0.26 | 0.01 | 0.97 | FALSE |
| 62 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TXNDC15 | 0.10 | 0.08 | enet | 5 | 0.07 | 1.4e-05 | -8.30 | 8.4 | 6.2e-17 | -0.26 | 0.01 | 0.99 | FALSE |
| 63 | The Cancer Genome Atlas | Thyroid Carcinoma | CAMLG | 0.26 | 0.21 | lasso | 2 | 0.21 | 5.2e-20 | -8.29 | -8.2 | 1.9e-16 | 0.26 | 0.00 | 1.00 | FALSE |
| 64 | The Cancer Genome Atlas | Thyroid Carcinoma | TXNDC15 | 0.07 | 0.02 | lasso | 5 | 0.07 | 4.8e-07 | -8.04 | 8.1 | 7.9e-16 | -0.28 | 0.02 | 0.98 | FALSE |