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chr5:133,045,139-134,935,530

Best TWAS P=8.6e-21 · Best GWAS P=1.27e-43 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
40	METSIM	Adipose	SAR1B	0.06	0.02	bslmm	288	0.03	3.1e-05	-8.29	-9.4	8.6e-21	0.15	0.54	0.02	TRUE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	CAMLG	0.08	0.05	lasso	1	0.04	1.8e-05	-8.29	-8.3	1.2e-16	0.27	0.00	1.00	TRUE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	TXNDC15	0.13	0.08	blup	43	0.09	9.7e-06	-8.30	8.1	5.0e-16	-0.29	0.01	0.99	TRUE
16	GTEx	Brain Putamen basal ganglia	TXNDC15	0.39	-0.01	enet	22	0.06	1.6e-02	-0.32	-7.9	2.3e-15	0.44	0.03	0.41	TRUE
45	YFS	Blood	TXNDC15	0.09	0.05	lasso	8	0.11	7.0e-33	-8.31	-7.3	2.2e-13	0.24	1.00	0.00	TRUE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TXNDC15	0.10	0.05	blup	41	0.05	2.4e-06	-8.04	6.1	8.5e-10	-0.15	0.01	0.99	TRUE
4	GTEx	Artery Aorta	TXNDC15	0.16	0.14	lasso	2	0.12	2.2e-07	5.93	5.9	2.9e-09	-0.25	0.98	0.00	TRUE
17	GTEx	Breast Mammary Tissue (Female)	CDKN2AIPNL	0.25	0.05	enet	28	0.06	7.2e-03	3.19	5.8	7.4e-09	-0.21	0.04	0.14	TRUE
54	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SAR1B	0.15	0.04	enet	10	0.05	1.3e-03	4.66	-5.2	2.6e-07	0.16	0.02	0.08	TRUE
19	GTEx	Cells Transformed fibroblasts	TXNDC15	0.38	0.31	lasso	11	0.33	4.8e-25	-8.33	9.1	1.1e-19	-0.30	1.00	0.00	FALSE
57	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TXNDC15	0.03	0.03	blup	35	0.03	5.6e-04	-8.04	9.0	2.3e-19	-0.28	0.01	0.93	FALSE
58	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TXNDC15	0.23	0.21	enet	10	0.20	1.1e-08	-8.33	9.0	3.5e-19	-0.28	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SAR1B	0.03	0.00	blup	27	0.01	2.6e-02	7.79	-8.8	1.4e-18	0.27	0.01	0.30	FALSE
26	GTEx	Lung	CAMLG	0.11	0.11	enet	7	0.11	9.1e-09	-8.30	-8.7	2.5e-18	0.26	1.00	0.00	FALSE
13	GTEx	Brain Frontal Cortex BA9	CAMLG	0.36	0.30	lasso	5	0.26	1.2e-07	-8.30	-8.7	3.3e-18	0.30	0.92	0.01	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	CAMLG	0.29	0.25	enet	8	0.32	2.3e-09	-8.29	-8.7	4.6e-18	0.27	0.97	0.00	FALSE
5	GTEx	Artery Aorta	CAMLG	0.22	0.17	lasso	3	0.12	2.2e-07	-8.30	-8.6	6.0e-18	0.27	1.00	0.00	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	CAMLG	0.13	0.07	lasso	3	0.05	2.0e-06	-8.29	-8.6	6.0e-18	0.28	0.00	1.00	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	PHF15	0.26	0.18	lasso	6	0.22	7.1e-08	7.71	8.6	6.6e-18	-0.20	0.71	0.03	FALSE
44	YFS	Blood	CAMLG	0.12	0.19	bslmm	295	0.20	1.2e-61	-8.30	-8.5	1.6e-17	0.27	1.00	0.00	FALSE
49	The Cancer Genome Atlas	Glioblastoma Multiforme	CAMLG	0.29	0.18	lasso	3	0.13	9.6e-05	-8.29	-8.5	2.1e-17	0.28	0.00	0.99	FALSE
9	GTEx	Brain Cerebellar Hemisphere	CAMLG	0.42	0.24	lasso	8	0.20	8.8e-06	-8.09	-8.5	2.2e-17	0.26	0.75	0.02	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	TXNDC15	0.05	0.06	lasso	3	0.06	1.9e-11	-8.30	8.5	2.2e-17	-0.26	0.01	0.99	FALSE
62	The Cancer Genome Atlas	Stomach Adenocarcinoma	TXNDC15	0.10	0.08	enet	5	0.07	1.4e-05	-8.30	8.4	6.2e-17	-0.26	0.01	0.99	FALSE
6	GTEx	Artery Coronary	CAMLG	0.27	0.20	lasso	8	0.12	5.3e-05	-8.09	-8.3	6.9e-17	0.24	0.85	0.01	FALSE
56	The Cancer Genome Atlas	Lung Adenocarcinoma	TXNDC15	0.05	0.05	lasso	1	0.04	1.0e-05	-8.33	8.3	8.0e-17	-0.25	0.01	0.99	FALSE
30	GTEx	Nerve Tibial	CAMLG	0.25	0.19	lasso	5	0.19	1.5e-13	-8.35	-8.3	9.9e-17	0.25	1.00	0.00	FALSE
7	GTEx	Artery Tibial	CAMLG	0.11	0.11	lasso	1	0.09	9.1e-08	-8.30	-8.3	1.0e-16	0.26	1.00	0.00	FALSE
11	GTEx	Brain Cerebellum	CAMLG	0.31	0.27	lasso	13	0.24	7.5e-08	-8.10	-8.3	1.0e-16	0.25	0.96	0.00	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	CAMLG	0.47	0.52	lasso	8	0.52	2.2e-79	-8.29	-8.3	1.0e-16	0.26	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CAMLG	0.39	0.35	lasso	6	0.34	1.8e-42	-8.29	-8.3	1.2e-16	0.26	1.00	0.00	FALSE
39	METSIM	Adipose	CAMLG	0.14	0.18	enet	8	0.21	4.0e-30	-8.30	-8.3	1.3e-16	0.26	1.00	0.00	FALSE
32	GTEx	Pituitary	CAMLG	0.20	0.07	enet	10	0.09	3.3e-03	-8.10	-8.3	1.4e-16	0.24	0.50	0.03	FALSE
38	GTEx	Thyroid	CAMLG	0.21	0.21	lasso	5	0.21	3.3e-16	-8.10	-8.3	1.6e-16	0.25	1.00	0.00	FALSE
8	GTEx	Brain Cerebellar Hemisphere	TXNDC15	0.51	0.48	lasso	5	0.47	1.2e-13	-8.04	-8.2	1.7e-16	0.26	1.00	0.00	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	CAMLG	0.26	0.21	lasso	2	0.21	5.2e-20	-8.29	-8.2	1.9e-16	0.26	0.00	1.00	FALSE
35	GTEx	Skin Sun Exposed Lower leg	CAMLG	0.11	0.05	lasso	2	0.03	2.9e-03	-8.10	-8.2	2.0e-16	0.22	0.55	0.10	FALSE
22	GTEx	Colon Transverse	TXNDC15	0.22	-0.01	lasso	7	-0.01	6.8e-01	-8.04	-8.2	2.6e-16	0.25	0.10	0.05	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	TXNDC15	0.07	0.04	lasso	4	0.04	6.2e-05	-8.04	8.2	2.7e-16	-0.26	0.01	0.97	FALSE
20	GTEx	Colon Sigmoid	TXNDC15	0.19	0.12	lasso	6	0.10	1.6e-04	-7.22	-8.2	3.1e-16	0.25	0.49	0.03	FALSE
50	The Cancer Genome Atlas	Glioblastoma Multiforme	TXNDC15	0.27	0.07	lasso	2	0.11	3.2e-04	-8.04	8.2	3.2e-16	-0.26	0.01	0.84	FALSE
14	GTEx	Brain Hypothalamus	CAMLG	0.28	0.28	lasso	4	0.25	1.3e-06	-8.10	-8.1	4.7e-16	0.24	0.67	0.02	FALSE
3	GTEx	Adipose Visceral Omentum	CAMLG	0.15	0.11	lasso	1	0.10	1.0e-05	-8.10	-8.1	5.5e-16	0.24	0.48	0.03	FALSE
12	GTEx	Brain Cortex	CAMLG	0.23	0.28	lasso	10	0.26	1.1e-07	-8.10	-8.1	5.8e-16	0.24	0.73	0.02	FALSE
24	GTEx	Esophagus Muscularis	CAMLG	0.23	0.17	lasso	5	0.15	1.3e-09	-8.09	-8.1	6.2e-16	0.22	1.00	0.00	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	TXNDC15	0.07	0.02	lasso	5	0.07	4.8e-07	-8.04	8.1	7.9e-16	-0.28	0.02	0.98	FALSE
10	GTEx	Brain Cerebellum	TXNDC15	0.48	0.36	lasso	4	0.48	5.7e-16	-8.04	-8.0	9.1e-16	0.26	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TXNDC15	0.05	0.04	lasso	1	0.03	4.8e-04	-8.04	8.0	9.4e-16	-0.25	0.01	0.94	FALSE
41	NTR	Blood	TXNDC15	0.05	0.05	lasso	2	0.05	2.7e-15	-8.04	-7.9	3.6e-15	0.25	1.00	0.00	FALSE
25	GTEx	Heart Atrial Appendage	CAMLG	0.14	0.03	lasso	4	0.03	2.0e-02	-8.29	-7.7	1.4e-14	0.21	0.28	0.04	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	TXNDC15	0.19	0.10	bslmm	324	0.14	1.2e-17	-8.04	-7.5	5.5e-14	0.31	1.00	0.00	FALSE
21	GTEx	Colon Sigmoid	CAMLG	0.16	0.01	lasso	3	0.00	2.9e-01	-8.09	-7.5	6.7e-14	0.21	0.10	0.05	FALSE
36	GTEx	Spleen	CAMLG	0.27	0.07	lasso	7	0.10	1.4e-03	-8.04	-7.4	1.1e-13	0.20	0.06	0.37	FALSE
31	GTEx	Pituitary	TXNDC15	0.32	0.18	lasso	6	0.23	1.9e-06	-8.04	-7.3	2.3e-13	0.25	0.50	0.05	FALSE
37	GTEx	Thyroid	TXNDC15	0.24	0.22	enet	8	0.24	3.0e-18	-8.33	-7.2	5.4e-13	0.21	1.00	0.00	FALSE
46	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CAMLG	0.10	0.04	blup	17	0.04	2.2e-04	-8.29	-7.2	6.4e-13	0.26	0.00	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SAR1B	0.12	0.06	lasso	6	0.09	8.1e-11	-7.69	-6.9	4.6e-12	0.22	0.99	0.00	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	SAR1B	0.04	0.01	enet	4	0.02	2.5e-03	6.50	-6.9	5.1e-12	0.16	0.03	0.09	FALSE
28	GTEx	Muscle Skeletal	CAMLG	0.08	0.01	enet	28	0.05	2.0e-05	-0.26	-6.9	5.5e-12	-0.05	0.05	0.04	FALSE
27	GTEx	Muscle Skeletal	SAR1B	0.10	0.04	lasso	7	0.04	6.1e-05	3.47	-6.6	3.7e-11	0.24	0.23	0.14	FALSE
23	GTEx	Colon Transverse	SAR1B	0.11	0.00	enet	17	0.03	1.2e-02	-7.22	-6.4	1.6e-10	0.17	0.07	0.04	FALSE
29	GTEx	Nerve Tibial	TXNDC15	0.26	0.17	lasso	5	0.20	6.9e-14	-8.04	-6.2	6.1e-10	0.17	1.00	0.00	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	TXNDC15	0.19	0.16	enet	16	0.11	8.6e-07	-8.04	-5.6	2.8e-08	0.13	1.00	0.00	FALSE
34	GTEx	Skin Sun Exposed Lower leg	TXNDC15	0.14	0.09	lasso	2	0.17	5.3e-14	-8.04	-5.3	9.1e-08	0.14	1.00	0.00	FALSE