Hub : Genes

CDKN2AIPNL

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue 0.1120 0.0540 0.0083 0.074 NA 0.002 NA 0.019 0.00012 NA 0.2600 NA 0.037
2 GTEx Breast Mammary Tissue (Male) 0.1883 0.0882 0.0170 0.011 NA -0.011 NA 0.040 0.18000 NA 0.6800 NA 0.042
3 GTEx Breast Mammary Tissue (Female) 0.2482 0.1036 0.0100 0.046 NA 0.060 NA 0.019 0.01700 NA 0.0072 NA 0.087
4 METSIM Adipose 0.0458 0.0220 0.0074 0.024 0.003 -0.001 0.005 0.006 0.00012 0.1100 0.4200 0.045 0.043
5 TCGA Stomach Adenocarcinoma 0.0340 0.0250 0.0091 0.011 0.024 0.024 NA 0.016 0.04800 0.0073 0.0073 NA 0.023

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.1 1.7 4.4 -1.2 -2.1 -1.3 -0.5 -0.9
Bipolar Disorder or Schizophrenia 1.5 3.6 7.4 -2.4 -2.1 -2.7 -0.5 -0.6
Depressed Affect (Nagel 2018) 0.2 0.3 1.1 -1.1 0.1 -0.5 -0.3 -0.3
Depression (Nagel 2018) 0.2 0.3 0.5 0.7 0.6 0.7 -0.2 0.1
Intelligence (Savage-Jansen 2018) 0.5 1.4 5.3 0.2 -0.4 0.6 -2.3 1.0
Neuroticism (Nagel 2018) 0.3 0.8 3.0 -1.7 0.4 -0.8 0.2 -0.1
Schizophrenia (2018) 1.0 2.1 5.6 -2.0 -1.0 -2.4 -0.2 -0.0
Schizophrenia vs Biploar Disorder 0.4 0.5 1.4 0.5 0.9 -0.1 0.3 1.2
Worry (Nagel 2018) 1.9 4.0 12.3 -3.5 -1.1 -2.0 -1.3 0.6
Alzheimer’s Disease (in mother) 0.4 0.4 1.3 -0.1 1.2 -0.3 0.7 0.3
Alzheimer’s Disease (in father) 0.9 1.0 1.7 -1.3 1.2 -1.3 -0.2 -0.4
Alzheimer’s Disease (including proxy) 0.6 0.8 3.1 -0.4 1.8 -0.9 0.4 0.2
Crohns Disease (2017) 0.5 1.1 2.1 0.5 1.2 1.3 -0.1 1.4
Irritable Bowel Disease (IBD) 0.2 0.4 1.3 -0.1 1.1 -0.1 -0.0 0.7
Ulcerative Colitis (UC) 0.3 0.6 1.6 -0.7 1.0 -1.3 0.4 0.1
Major Depression (MDD) 0.2 0.3 0.9 0.1 -0.0 -0.1 0.6 -1.0
Reaction Time 2.3 4.4 6.8 2.6 0.8 1.9 2.5 2.2
Verbal and Numeric Reasoning (VNR) 0.8 1.8 4.2 -1.4 -0.8 -0.5 -2.0 1.4
Breast Cancer 0.2 0.5 1.2 -0.4 -0.8 0.0 -1.1 -0.5
Ovarian Cancer 0.3 0.4 1.6 -0.1 -0.3 0.4 -1.3 0.4
Prostate Cancer 1.4 2.0 4.8 1.3 0.4 2.2 -0.1 1.8
Age at First Birth 0.8 1.2 2.1 1.4 -1.2 1.5 0.1 0.8
Bipolar Disorder (2011) 1.4 1.3 4.9 0.0 -1.3 0.4 0.0 -2.2
Body Mass Index (BMI) (2010) 0.2 0.2 0.4 0.4 0.4 -0.2 -0.7 -0.6
Coronary Artery Disease (CAD) 0.7 0.8 3.1 0.0 0.7 -0.8 1.8 -0.0
Crohns Disease (2012) 0.5 0.8 2.6 1.6 0.4 0.9 -0.4 0.4
Mean Putamen Volume 0.9 1.1 3.7 0.8 0.6 0.8 1.9 0.1
Fasting Glucose 0.5 0.6 2.1 0.0 0.5 0.6 1.4 -0.4
HbA1C 1.7 1.9 4.3 -1.3 -1.1 -2.1 -0.9 -1.2
HDL Cholesterol 0.1 0.2 0.6 -0.2 -0.2 0.8 -0.3 -0.6
LDL Cholesterol 0.8 1.3 3.2 0.2 1.7 -0.1 1.8 0.4
Lupus 1.5 2.3 9.5 0.8 -1.2 -0.0 -0.3 -3.1
Neuroticism (2016) 0.2 0.3 1.0 1.0 0.2 0.5 0.1 0.6
Primary Biliary Cirrhosis 1.1 1.6 5.2 2.3 0.5 1.6 0.5 0.2
Rheumatoid Arthritis 0.8 1.2 2.8 -0.8 -0.7 0.1 1.3 -1.7
Schizophrenia (2014) 2.1 4.5 9.7 -2.2 -2.3 -3.1 -0.9 -1.4
Triglycerides 0.3 0.5 0.7 -0.7 0.6 -0.8 -0.7 -0.8
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.8 -1.1 0.5 -0.6 1.4 -0.4
Ulcerative Colitis 0.3 0.4 0.7 0.7 0.4 -0.5 0.6 0.9
Blood Eosinophil Count 0.3 2.2 9.1 1.4 -0.4 0.3 0.2 -3.0
Blood Platelet Count 0.2 2.3 11.3 -0.1 -3.4 0.4 -0.2 0.5
Blood Red Count 0.0 0.2 0.8 0.2 -0.0 -0.9 -0.4 -0.2
Blood White Count 0.1 0.4 1.6 -0.6 -0.3 -0.2 -1.3 0.2
Heel T-Score 0.9 7.0 17.7 0.4 -3.2 -1.2 -2.3 -4.2
BMI 0.7 3.8 10.6 -1.6 1.3 -3.3 -1.1 -1.8
Height 1.0 20.1 54.8 3.1 -3.8 7.4 4.7 -0.4
Waist Hip Ratio (WHR) 0.6 2.6 8.5 0.2 1.9 -0.7 0.7 2.9
Systolic Blood Pressure 0.3 1.3 2.1 -1.1 0.5 -1.0 -1.3 -1.5
Smoking Status 0.4 1.0 2.4 -1.3 -0.2 -0.4 0.9 1.5
Allergy or Eczema 0.9 2.4 3.0 1.5 -1.6 1.7 1.2 1.6
Cardiovascular Disease 0.5 1.6 3.0 -1.0 1.0 -1.7 -1.0 -1.4
Hypothyroidism (self reported) 1.0 2.4 8.5 0.5 -1.3 -0.4 1.1 -2.9
Respiratory disease 0.6 1.3 3.0 0.2 -0.9 1.7 0.4 1.6
Type 2 Diabetes (T2D) (2018) 0.8 1.4 3.5 0.5 0.1 0.9 1.9 1.6
Lung FEV1/FVC ratio 0.8 4.1 15.8 -0.3 -0.4 -2.2 -4.0 0.2
Lung FVC 0.2 0.9 3.2 0.7 -1.8 0.7 -0.4 -0.2
Neuroticism 0.3 0.8 2.7 -1.6 0.3 -0.7 -1.0 -0.2
Chronotype (morning person) 1.3 3.1 6.7 -1.7 2.1 0.9 2.6 -0.7
Hair Pigment 0.1 3.8 6.7 -2.5 0.1 -0.6 2.6 2.4
Tanning 0.1 1.0 2.2 0.8 1.5 0.5 0.9 -1.0
Hand grip strength (left) 0.9 2.4 5.3 1.6 -1.7 2.3 0.9 -0.5
Number of treatments/medications taken 0.9 1.5 4.1 -0.5 -1.4 0.5 1.0 2.0
Average weekly spirits intake 0.8 1.0 3.0 -0.9 1.7 -0.3 1.0 0.2
Sensitivity / hurt feelings 0.4 0.7 1.5 0.5 0.8 0.7 -0.7 -1.2
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.9 -0.0 -0.5 0.0 -0.9 0.1
Hearing difficulty/problems: Yes 0.2 0.4 1.3 0.3 0.6 1.1 0.2 -0.0
Relative age of first facial hair 0.6 1.2 3.0 1.7 -0.5 1.6 0.1 -0.4
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.9 -0.9 -0.9 0.3 -0.8 -0.1
Ever used hormone-replacement therapy (HRT) 1.2 1.5 2.6 -1.6 0.4 -1.6 1.3 0.9
Ever had hysterectomy (womb removed) 1.0 1.1 4.0 -2.0 0.4 -1.0 0.5 0.1
Systolic blood pressure, automated reading 0.7 1.9 4.4 -2.1 1.2 -1.6 -0.3 -1.1
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.8 -0.9 0.1 -0.5 -0.2 -0.3
Angina 0.6 0.8 1.7 -1.1 -1.3 -1.0 -0.4 0.1
Medication for hormone replacement therapy 0.4 0.4 0.8 0.6 0.6 0.1 0.9 0.7
Vitamin and mineral supplements 1.0 1.4 5.3 1.0 0.7 0.2 -0.2 -2.3
Supplements: Zinc 0.9 0.9 2.0 -0.3 -1.4 -0.5 -1.4 0.7
Medication: Co-codamol 1.5 1.8 4.1 -1.2 -1.2 -0.8 -2.0 1.1
Medication: Metformin 1.2 1.7 4.8 0.4 0.4 1.3 1.3 2.2
Diabetes (father) 0.3 0.3 1.2 -0.4 -0.2 -1.1 -0.3 -0.2
Diabetes (mother) 0.3 0.4 0.7 0.7 -0.8 -0.8 -0.4 -0.1
Severe depression (siblings) 0.7 0.8 2.5 -0.4 -1.6 0.4 -0.7 -0.7
Pack years adult smoking proportion 0.2 0.3 0.9 0.7 0.6 0.2 -0.1 0.9
Impedance of leg (right) 0.2 0.9 3.3 0.6 -1.8 0.2 0.0 0.9
Leg fat-free mass (left) 0.1 0.7 1.6 0.2 -0.5 1.0 0.9 -1.3
Trunk fat percentage 0.3 1.1 2.6 -1.5 0.7 -1.6 -0.2 0.4
Hand grip strength (right) 1.1 2.9 7.4 2.0 -0.2 2.7 1.4 1.0
Townsend deprivation index at recruitment 0.6 0.9 3.5 -1.9 0.3 -0.7 0.4 -0.1
Current tobacco smoking 0.2 0.4 1.6 -0.4 -0.1 0.2 0.3 1.2
Average weekly fortified wine intake 0.7 0.9 2.9 -1.0 -1.7 -0.4 -0.3 -0.5
Maternal smoking around birth 0.9 1.3 3.1 -0.7 -1.3 -0.8 -1.8 0.7
Fed-up feelings 0.5 0.9 1.2 -1.1 -0.3 -1.1 -1.0 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.6 0.0 -0.8 -0.1 -0.6 -0.1
Relative age voice broke 0.7 1.1 2.3 0.8 -0.8 1.5 -0.1 1.4
Taking other prescription medications 1.7 2.6 5.5 -0.3 -2.4 1.2 0.7 2.3
Age when periods started (menarche) 3.7 8.9 21.3 4.6 -0.8 4.3 1.8 0.9
Bilateral oophorectomy (both ovaries removed) 2.9 3.4 10.8 -3.3 0.4 -2.3 0.6 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.5 7.8 -0.3 -2.4 -0.9 -1.6 -2.8
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 2.5 -0.1 1.4 0.6 1.6 1.4
Qualifications: CSEs or equivalent 0.1 0.2 0.3 0.4 -0.3 -0.5 0.3 -0.4
Serious illness, injury or assault to yourself 0.6 0.7 1.9 -0.5 -1.4 0.0 -0.3 -1.1
High blood pressure 0.4 1.1 2.7 -0.9 0.4 -1.6 -1.2 0.5
Hayfever, allergic rhinitis or eczema 0.8 1.7 3.6 1.2 -1.9 1.1 1.1 1.0
Multivitamins +/- minerals 0.9 1.2 3.0 -0.8 -1.4 0.2 -0.4 1.7
Stomach or abdominal pain in last month 0.3 0.3 0.5 0.6 -0.7 0.4 -0.6 -0.6
Supplements: Glucosamine 0.7 0.9 2.9 -0.5 0.9 -1.7 -0.8 -0.2
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 3.2 -1.2 -0.3 -1.8 -1.1 -0.2
Medication: Atenolol 0.5 0.6 1.7 -0.8 -1.3 -0.5 0.5 0.1
Medication: Levothyroxine sodium 1.0 1.6 6.1 0.4 0.4 0.1 1.3 -2.5
Sitting height 0.8 5.5 13.2 2.1 -2.2 3.6 0.8 -2.0
Chronic bronchitis/emphysema (father) 0.2 0.3 0.8 -0.9 -0.4 -0.5 -0.1 -0.4
High blood pressure (mother) 1.0 1.5 4.3 1.1 1.3 0.3 -2.1 0.1
Body mass index (BMI) 0.7 3.2 8.0 -2.2 1.4 -2.8 -0.5 -0.8
Impedance of leg (left) 0.2 0.8 2.3 0.2 -1.5 0.1 -0.6 1.2
Leg predicted mass (left) 0.1 0.8 1.5 0.2 -0.6 1.0 0.9 -1.2
Trunk fat mass 0.1 0.5 1.5 -1.2 0.2 -0.9 0.1 0.2
Waist circumference 0.4 1.6 4.4 -1.6 0.7 -2.1 -0.3 0.6
Number of incorrect matches in round 0.6 0.9 2.1 0.5 -1.4 0.2 1.0 -1.2
Past tobacco smoking 1.1 2.1 7.4 1.3 1.0 0.0 -0.3 -2.7
Alcohol usually taken with meals 0.6 0.9 2.2 1.2 -0.7 1.5 -0.1 -0.7
Nervous feelings 2.3 4.4 10.4 -3.2 -1.4 -3.0 -0.7 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.9 -0.3 -0.0 -1.0 -1.7 1.3
Hearing difficulty/problems with background noise 0.6 1.0 3.5 0.3 0.7 0.3 1.9 -0.9
Hair/balding pattern: Pattern 2 0.4 0.5 0.9 1.0 0.2 0.5 -0.8 0.8
Had menopause 1.5 1.8 3.7 -1.9 1.1 -1.6 -1.2 -0.4
Had other major operations 1.0 1.2 5.3 -0.4 -0.2 0.3 -0.7 2.3
Forced vital capacity (FVC) 0.9 3.3 6.7 2.0 -2.3 2.6 0.9 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 4.4 0.3 -1.7 -0.5 -1.3 -2.1
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.2 -0.6 -0.4 -0.7 -0.2 1.5
Qualifications: None of the above 0.5 1.0 1.9 -1.2 0.2 -1.1 0.7 1.4
Financial difficulties in last 2 years 2.0 2.7 8.6 0.2 1.0 -0.5 -1.9 2.9
Mouth/teeth dental problems 0.6 1.0 2.1 1.4 1.5 0.4 0.0 0.7
Heart attack 1.7 2.2 5.2 0.8 -2.3 1.2 -0.4 1.9
Allergy 1.2 2.8 5.4 -1.6 1.5 -2.3 -0.7 -1.7
Pain all over the body in last month 0.2 0.2 0.5 0.5 -0.2 0.4 -0.7 -0.1
Diabetes (self-reported) 1.5 2.3 5.0 1.4 0.7 1.4 1.5 2.2
Hayfever/allergic rhinitis (self-reported) 1.3 1.8 5.0 0.9 -1.4 2.2 0.8 0.7
Medication: Ramipril 0.1 0.2 0.6 -0.4 -0.7 -0.3 -0.1 0.2
Medication: Simvastatin 0.6 0.9 3.2 0.4 1.8 0.4 0.8 -0.4
Fluid intelligence score 1.0 2.1 3.2 -1.7 -1.4 -1.0 -1.8 1.0
Illnesses of siblings 2.2 3.1 8.7 1.0 -2.9 1.5 0.5 -1.9
Neuroticism score 0.3 0.7 2.1 -1.4 -0.2 -0.7 -0.8 0.0
Weight 0.1 0.3 0.9 -1.0 -0.3 -0.2 0.4 -0.6
Impedance of arm (right) 0.7 3.1 5.3 2.3 -0.3 2.3 1.1 2.0
Arm fat percentage (right) 0.5 1.9 4.6 -1.6 1.2 -2.1 -0.3 0.7
Trunk fat-free mass 0.4 2.3 3.5 0.6 -1.9 1.9 1.1 -1.8
Hip circumference 0.2 0.8 1.9 -1.4 -0.2 -1.1 0.7 -0.8
Time employed in main current job 0.5 0.6 1.9 -0.5 0.9 -1.4 -0.3 0.3
Alcohol intake versus 10 years previously 0.2 0.3 0.8 0.3 -0.9 -0.2 -0.8 -0.3
Father’s age at death 0.8 1.0 2.2 -0.6 -1.5 0.8 1.3 -0.7
Worrier / anxious feelings 0.2 0.4 0.9 -1.0 -0.8 0.3 -0.1 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.6 -0.0 -0.5 -0.0 -0.5 -0.8
Falls in the last year 0.1 0.2 0.5 0.4 0.3 0.4 0.7 -0.3
Hair/balding pattern: Pattern 3 1.6 2.4 5.4 -0.1 1.9 0.3 2.3 -1.7
Number of live births 0.2 0.3 0.6 0.2 0.8 -0.7 -0.1 -0.6
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 4.0 1.9 -2.0 1.6 -0.2 -0.4
Pulse rate 0.6 1.0 2.9 1.7 1.3 0.4 0.3 -0.4
Happiness 0.3 0.3 0.7 0.9 -0.6 0.3 -0.1 -0.7
Noisy workplace 0.5 0.6 1.2 0.6 -0.5 0.9 -0.4 1.1
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.1 -0.4 -0.8 -0.3 -1.0 -0.5
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 2.6 0.6 1.1 1.6 1.2 1.4
Mouth/teeth dental problems: Dentures 1.4 2.3 5.9 -1.2 -2.4 -0.7 -1.4 -1.3
Asthma 1.2 2.4 7.7 0.8 -0.7 1.8 0.2 2.8
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.1 -0.5 0.8 -0.5 1.1 -0.8
Medication: Cholesterol lowering 1.6 2.5 6.6 0.8 0.1 2.6 2.0 1.2
Depression (self-reported) 1.4 1.7 5.9 1.0 -1.0 -0.6 -2.4 0.2
Medication: Lansoprazole 0.3 0.4 0.9 -0.0 -0.3 0.9 -0.0 1.0
Prospective memory result 0.4 0.4 0.9 -0.3 0.5 0.7 0.7 1.0
Lung cancer (father) 0.5 0.5 1.2 -0.4 -0.8 -1.1 -0.6 0.6
Illnesses of mother 1.2 1.4 3.8 0.2 0.5 0.3 1.9 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 2.3 1.4 -1.5 1.4 -0.4 -0.8
Pulse wave Arterial Stiffness index 0.7 0.8 2.7 0.3 -0.5 -0.4 -0.9 1.6
Impedance of arm (left) 0.6 2.9 5.0 2.1 0.4 2.2 1.4 1.7
Arm fat mass (right) 0.2 0.9 2.2 -1.3 0.6 -1.5 0.1 -0.1
Trunk predicted mass 0.4 2.2 3.6 0.6 -1.8 1.9 1.0 -1.6
Standing height 1.2 11.9 33.4 2.9 -3.5 5.8 2.3 0.4
Length of working week for main job 0.9 1.0 2.8 0.1 0.9 -1.1 -1.7 -0.2
Exposure to tobacco smoke at home 0.7 0.8 1.8 0.5 1.3 -0.7 0.1 -1.2
Breastfed as a baby 1.6 2.0 5.5 1.3 -1.1 1.2 2.4 -0.1
Tense / ‘highly strung’ 0.1 0.2 0.4 -0.5 0.4 0.1 -0.3 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 3.0 -1.3 -1.7 -1.0 0.0 0.1
Hair/balding pattern: Pattern 4 0.3 0.8 3.3 -0.4 -1.8 0.5 0.4 -0.2
Birth weight of first child 2.1 3.8 9.2 3.0 -1.2 1.5 2.4 -0.7
Peak expiratory flow (PEF) 0.4 0.8 2.7 0.3 -0.8 -0.5 -1.6 -0.7
Pulse wave reflection index 1.0 1.2 5.7 -0.0 0.7 0.2 -0.0 2.4
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.5 0.9 0.7 0.5 -0.1 1.2
Loud music exposure frequency 0.5 0.6 1.7 0.3 -1.0 -0.2 -1.3 0.1
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 4.8 -0.6 -2.2 -0.4 -1.4 -1.2
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.5 -0.6 1.2 -1.2 1.0 -0.0
Blood clot in the leg (DVT) 0.2 0.3 0.8 -0.2 0.5 0.1 -0.4 0.9
Medication: Paracetamol 0.1 0.2 0.9 0.2 -1.0 0.3 0.1 -0.0
Headache pain in last month 0.4 0.7 3.2 -0.4 -1.8 0.3 0.4 0.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.1 0.1 0.1 -1.1 -0.1 -0.8
Glaucoma (self-reported) 0.5 0.6 1.1 -0.9 -1.1 0.2 -0.9 -0.1
Gout (self-reported) 1.0 1.4 4.1 0.3 0.4 0.5 1.5 2.0
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 9.6 -0.3 -0.6 -1.0 0.3 -3.1
Medication: Amlodipine 0.8 1.1 2.7 0.6 -0.1 0.4 1.4 1.7
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.7 -0.5 0.1 -0.9 0.0 0.2
Birth weight 1.6 3.5 6.1 2.4 -2.5 2.3 0.4 -0.1
Chronic bronchitis/emphysema (mother) 0.9 1.0 3.4 -0.7 0.8 -0.8 -1.8 -0.3
High blood pressure (siblings) 1.3 1.9 6.1 -0.8 2.5 -1.2 -0.8 0.7
Forced vital capacity (FVC), Best measure 0.6 2.4 4.7 1.7 -1.9 2.2 0.5 -0.5
Body fat percentage 0.5 2.0 5.7 -1.9 0.8 -2.4 -0.3 0.4
Leg fat percentage (right) 0.9 3.4 10.6 -2.3 0.6 -3.2 -0.7 0.5
Arm fat-free mass (right) 0.3 1.7 4.6 -0.2 -1.7 0.7 0.5 -2.1
Exposure to tobacco smoke outside home 0.6 0.8 3.4 0.3 0.5 0.4 0.6 1.8
Comparative body size at age 10 0.2 0.5 0.9 -0.6 1.0 -0.6 0.6 0.5
Number of full brothers 0.4 0.5 0.8 0.2 0.9 0.7 -0.7 0.7
Worry too long after embarrassment 1.4 2.4 6.9 0.5 1.5 1.6 2.6 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 2.0 2.5 6.6 -2.6 -0.9 -2.0 -1.0 -0.4
Wheeze or whistling in the chest in last year 0.7 1.2 3.3 0.8 0.8 1.8 0.4 1.2
Number of children fathered 1.6 1.8 3.9 1.4 0.7 0.9 -2.0 1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.4 -1.2 -0.4 -0.4 -0.2 -0.2
Age at first live birth 1.4 2.5 2.8 1.5 -1.6 1.6 1.7 -1.6
Pulse wave peak to peak time 0.7 0.8 2.5 -0.2 0.0 0.8 0.9 -1.6
Health satisfaction 0.3 0.4 1.0 0.7 -0.4 -0.2 -1.0 -0.6
Shortness of breath walking on level ground 0.5 0.6 2.0 0.4 1.4 -0.5 -0.5 0.7
Qualifications: College or University degree 0.5 1.6 3.6 1.9 -0.7 1.4 -0.9 -1.1
Eye problems/disorders: None of the above 0.5 0.5 0.9 0.7 1.0 0.7 -0.1 0.9
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.7 -1.0 -1.3 -0.4 -0.7 0.9
Emphysema/chronic bronchitis 1.1 1.2 4.0 -0.3 -0.9 1.0 0.5 -2.0
Medication for pain relief, constipation, heartburn 0.2 0.4 1.0 0.7 0.7 -0.1 -1.0 -0.1
Neck or shoulder pain in last month 0.6 0.9 3.6 -0.2 -1.9 0.7 0.6 0.0
Medication: Blood pressure 0.5 1.0 2.3 -0.1 -1.4 1.5 -0.0 0.8
Angina (self-reported) 0.5 0.6 1.5 -0.9 -1.2 -0.8 0.0 0.1
Migraine (self-reported) 0.4 0.5 2.1 1.4 0.2 0.4 -0.1 -0.2
Medication: Ibuprofen 0.5 0.6 2.3 0.7 0.1 0.2 0.4 -1.5
Medication: Allopurinol 1.2 1.6 4.0 1.0 -0.1 0.9 2.0 1.5
Medication: Omeprazole 0.5 0.6 1.8 -1.4 -0.2 -0.5 -0.8 0.4
Medication: Seretide 50 evohaler 0.2 0.2 0.6 0.3 -0.3 0.5 -0.1 0.7
Mean time to correctly identify matches 2.1 4.0 5.6 2.2 0.9 2.1 2.4 2.1
Heart disease (mother) 1.2 1.5 3.0 -0.2 -1.5 -0.6 -1.3 -1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 1.6 1.2 -1.3 0.9 -0.8 1.2
Whole body fat mass 0.2 1.0 2.5 -1.5 0.1 -1.6 0.1 0.2
Leg fat mass (right) 0.4 1.5 4.6 -1.6 0.2 -2.1 -0.2 0.2
Arm predicted mass (right) 0.3 1.5 4.2 -0.3 -1.6 0.7 0.6 -2.0
Pulse rate, automated reading 0.2 0.7 1.9 -0.6 0.5 -1.4 0.7 -0.5
Alcohol intake frequency. 0.7 1.6 3.6 -1.3 0.9 -1.9 -0.5 -1.2
Comparative height size at age 10 0.3 1.8 5.1 -0.0 -1.4 2.2 0.3 1.2
Number of full sisters 1.4 1.7 5.4 1.2 -0.1 0.9 -0.7 2.3
Suffer from ‘nerves’ 2.4 3.7 5.8 -2.4 -1.4 -2.4 -1.6 1.6
Overall health rating 0.5 1.1 3.5 -1.3 -0.3 -0.2 1.9 0.1
Chest pain or discomfort 0.3 0.4 1.6 -0.4 -1.3 0.3 -0.4 0.2
Had major operations 1.0 1.2 4.9 -0.9 -2.2 0.0 0.4 -0.5
Age at last live birth 0.9 1.3 2.7 1.1 -1.2 1.6 1.0 -0.1
Family relationship satisfaction 0.3 0.4 1.1 -1.1 0.3 -0.1 -0.5 -0.8
Leg pain on walking 0.5 0.6 1.4 0.0 0.5 -1.1 -1.2 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.9 -0.5 -0.7 0.3 -1.4 0.0
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.9 -0.3 1.4 -1.3 -0.4 0.8
Illness, injury, bereavement, stress in last 2 years 2.2 2.7 6.2 1.6 -0.8 1.5 1.3 -2.5
Medication: Aspirin 0.4 0.6 1.0 -0.9 -0.7 -0.3 1.0 0.5
Supplements: Vitamin C 1.6 1.9 3.5 -1.6 0.2 -1.9 0.7 1.7
Knee pain experienced in last month 0.6 0.9 2.3 -1.5 1.0 -0.6 0.7 0.7
Hypertension (Self-reported) 0.3 0.9 1.7 -0.7 0.6 -1.3 -1.1 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.0 -0.4 -0.6 0.5 -1.0 0.4
Illnesses of father: Heart disease 1.2 1.6 4.9 -2.2 -0.3 -1.5 -0.1 -0.8
Illnesses of siblings: Diabetes 0.6 0.7 1.9 0.3 0.8 -0.3 0.8 1.4
Smoking status: Previous 0.7 1.0 2.6 -1.1 -1.1 -0.2 0.0 1.6
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.7 6.3 0.8 -2.5 2.5 -0.5 -0.3
Whole body fat-free mass 0.3 1.6 3.0 0.3 -1.4 1.5 1.0 -1.7
Leg fat-free mass (right) 0.1 0.7 1.5 0.2 -0.3 1.2 0.8 -1.2
Arm fat percentage (left) 0.4 1.8 3.7 -1.5 1.6 -1.9 -0.1 0.3
Average weekly red wine intake 0.6 0.8 1.7 0.9 1.3 0.9 0.5 -0.7
Handedness (chirality/laterality): Left-handed 1.2 1.5 4.5 -2.1 -1.5 -0.5 -0.6 0.3
Mood swings 0.3 0.6 1.5 -1.2 0.2 -0.4 0.1 -1.1
Loneliness, isolation 0.6 0.8 1.5 1.2 -0.8 1.1 -0.9 0.2
Long-standing illness, disability or infirmity 0.6 0.9 2.0 -1.4 -1.1 0.0 0.7 1.0
Ever had bowel cancer screening 0.8 0.9 2.8 -0.5 1.7 -0.0 1.0 -0.7
Diabetes diagnosed by doctor 1.8 3.0 7.6 0.4 1.2 1.3 2.0 2.8
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.4 -1.0 0.7 -1.2 0.7 0.1
Friendships satisfaction 0.2 0.2 0.7 -0.9 -0.3 0.1 -0.0 -0.5
Qualifications: nursing, teaching 0.9 1.4 3.5 1.5 0.7 1.9 -0.2 0.9
Commuting to job workplace: Walk 0.4 0.4 0.9 0.9 -0.2 0.4 1.0 0.4
Eye problems/disorders: Cataract 0.4 0.5 1.4 -0.2 -1.0 -0.3 0.2 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.5 -0.1 -1.6 1.1 0.9 0.6
Medication for cholesterol 0.5 0.8 2.6 -0.7 -1.6 0.6 -0.3 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.7 -0.5 0.9 0.0 1.3 0.6
Back pain experienced in last month 2.5 3.6 6.6 -2.3 -2.6 -0.6 -0.6 2.4
Mineral and other dietary supplements 0.7 0.9 2.8 0.9 0.4 0.8 -0.3 -1.7
Breast cancer (self-reported) 0.9 1.1 2.7 1.6 -0.6 1.0 -0.2 -1.2
Asthma (self-reported) 1.3 2.6 7.8 0.8 -0.9 1.9 0.4 2.8
Osteoporosis (self-reported) 0.9 1.1 4.9 -0.4 -0.1 0.2 -0.3 2.2
Osteoarthritis (self-reported) 2.0 2.6 4.9 -2.0 0.1 -2.2 0.3 -1.9
Medication: Aspirin 0.2 0.3 0.7 -0.8 -0.3 -0.1 0.8 0.2
Medication: Gliclazide 2.8 3.1 5.2 1.3 1.2 1.8 2.3 2.0
Illnesses of father: None of the above (group 1) 1.7 2.2 5.7 2.1 0.1 2.4 0.8 0.1
Smoking status: Current 0.2 0.3 1.4 -0.5 -0.1 -0.1 -0.0 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.7 2.0 1.4 -0.4 0.4 -0.9 -0.7
Whole body water mass 0.3 1.6 3.1 0.2 -1.4 1.3 0.9 -1.8
Leg predicted mass (right) 0.1 0.7 1.6 0.2 -0.2 1.1 0.8 -1.3
Arm fat mass (left) 0.3 1.1 2.5 -1.5 0.6 -1.6 0.1 -0.1
Number of self-reported non-cancer illnesses 0.4 0.6 2.2 -0.4 -0.4 0.4 0.5 1.5
Average weekly champagne plus white wine intake 0.4 0.5 1.0 0.9 -0.5 0.6 -0.1 -1.0
Miserableness 0.1 0.2 0.5 -0.7 -0.4 0.1 -0.4 0.0
Guilty feelings 1.0 1.5 4.3 0.7 1.6 -0.2 2.1 -0.2
Wears glasses or contact lenses 1.2 1.4 3.1 -0.9 -1.3 -1.2 -1.8 0.5
Ever taken oral contraceptive pill 0.5 0.5 1.6 0.3 0.9 1.3 -0.2 0.3
Hearing aid user 0.4 0.4 0.9 0.8 0.7 0.3 0.4 -0.9
Mother’s age at death 0.4 0.5 1.8 0.1 0.5 0.5 1.3 0.1
Financial situation satisfaction 2.0 2.5 4.8 2.2 1.0 2.2 -0.4 1.4
Tinnitus: Yes, now most or all of the time 0.8 1.0 2.4 1.5 0.5 0.4 -1.2 -0.7
Commuting to job workplace: Public transport 1.3 1.5 3.7 1.9 -0.6 0.9 1.0 -1.3
Eye problems/disorders: Glaucoma 0.5 0.6 1.1 -1.1 -1.1 -0.1 -0.4 -0.6
Medication: Blood pressure 0.2 0.4 1.0 0.5 0.7 -1.0 -0.1 0.6
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.8 -1.4 -0.7 -0.8 -0.5 1.0
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.5 -1.0 -0.5 -0.8 0.3 1.2
High cholesterol (Self-reported) 0.2 0.3 0.6 -0.8 -0.4 0.1 -0.5 -0.7
Medication: Bendroflumethiazide 0.1 0.1 0.4 0.0 -0.1 0.3 0.6 0.2
Medication: Paracetamol 0.3 0.5 1.6 0.1 -1.2 0.6 -0.6 0.4
Medication: Lisinopril 1.0 1.3 4.4 -0.7 -0.2 -0.6 -1.2 2.1
Medication: Atorvastatin 0.7 0.8 2.7 -0.0 -1.7 1.0 -0.6 0.4
Illnesses of father: High blood pressure 0.8 1.0 3.3 1.8 0.9 0.9 0.1 0.6
Alcohol drinker status: Never 1.9 2.3 4.5 -0.9 1.7 -2.1 -0.9 -1.5
Ever smoked 1.7 3.0 11.7 -0.9 -1.3 0.5 0.7 3.4
Basal metabolic rate 0.2 1.0 2.2 -0.1 -1.1 1.0 0.8 -1.5
Leg fat percentage (left) 1.1 4.0 10.9 -2.6 0.8 -3.3 -1.1 0.5
Arm fat-free mass (left) 0.2 1.1 2.8 -0.3 -1.4 0.4 0.5 -1.7
Number of operations (self-reported) 0.7 1.1 2.4 -1.3 -1.6 -0.2 -0.9 0.4
Average weekly beer plus cider intake 0.1 0.2 0.5 -0.1 0.4 -0.3 -0.7 -0.2
Irritability 0.4 0.7 2.1 -1.2 0.5 0.0 1.4 -0.2
Risk taking 0.3 0.4 0.9 0.8 0.2 0.1 -1.0 0.5
Ever had prostate specific antigen (PSA) test 1.1 1.2 2.6 -1.3 -0.4 -1.3 -1.6 0.3
Fractured/broken bones in last 5 years 0.0 0.1 0.1 0.2 -0.3 -0.0 -0.3 0.2
Age started oral contraceptive pill 0.7 0.8 1.7 1.3 -0.6 1.1 0.9 -0.1
Diastolic blood pressure, automated reading 1.0 3.0 5.3 -2.3 1.5 -2.1 -1.0 -1.5
Ever depressed for a whole week 0.1 0.2 0.7 -0.2 -0.1 -0.4 -0.8 0.2
Unable to work because of sickness or disability 0.6 0.7 2.0 0.7 0.2 -0.5 -1.4 -1.0
Commuting to job workplace: Cycle 2.8 3.3 7.9 1.5 -1.5 2.8 -0.9 -1.9
Myopia 0.7 1.1 3.4 0.2 -0.9 -1.1 -1.8 0.2
Vascular/heart problems diagnosed by doctor 0.5 1.3 3.6 1.1 0.1 1.9 1.2 -0.3
Cholesterol lowering medication 0.4 0.5 2.1 0.6 1.4 0.1 -0.4 0.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.5 -0.7 0.7 0.1 -0.3 0.2
Pain experienced in last month 0.6 1.0 2.0 0.7 1.2 -1.4 0.0 -1.1
Supplements: Calcium 3.9 4.3 16.9 -0.7 -1.7 0.4 -1.1 4.1
Basal cell carcinoma (self-reported) 1.6 1.9 8.5 -2.9 0.5 -1.0 -0.1 -0.1
Heart attack/myocardial infarction (self-reported) 1.7 2.2 4.7 0.8 -2.2 1.2 -0.2 2.1
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.6 -0.3 0.3 -0.1 -0.7 0.8
Heart disease (siblings) 2.4 2.9 4.7 -2.1 2.2 -1.7 1.6 -0.1
Alcohol drinker status: Previous 0.9 1.1 4.8 -0.5 2.2 0.1 -0.5 -0.1
Pack years of smoking 0.1 0.1 0.3 0.6 0.3 0.2 -0.1 0.5
Impedance of whole body 0.3 1.5 2.9 1.4 -0.5 1.5 0.6 1.7
Leg fat mass (left) 0.4 1.7 4.5 -1.9 0.3 -2.1 -0.6 0.2
Arm predicted mass (left) 0.3 1.3 3.0 -0.5 -1.7 0.2 0.4 -1.7