Hub : Genes

CDKN2AIPNL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.1120	0.0540	0.0083	0.074	NA	0.002	NA	0.019	0.00012	NA	0.2600	NA	0.037
2	GTEx	Breast Mammary Tissue (Male)	0.1883	0.0882	0.0170	0.011	NA	-0.011	NA	0.040	0.18000	NA	0.6800	NA	0.042
3	GTEx	Breast Mammary Tissue (Female)	0.2482	0.1036	0.0100	0.046	NA	0.060	NA	0.019	0.01700	NA	0.0072	NA	0.087
4	METSIM	Adipose	0.0458	0.0220	0.0074	0.024	0.003	-0.001	0.005	0.006	0.00012	0.1100	0.4200	0.045	0.043
5	TCGA	Stomach Adenocarcinoma	0.0340	0.0250	0.0091	0.011	0.024	0.024	NA	0.016	0.04800	0.0073	0.0073	NA	0.023

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.1	1.7	4.4	-1.2	-2.1	-1.3	-0.5	-0.9
Bipolar Disorder or Schizophrenia	1.5	3.6	7.4	-2.4	-2.1	-2.7	-0.5	-0.6
Depressed Affect (Nagel 2018)	0.2	0.3	1.1	-1.1	0.1	-0.5	-0.3	-0.3
Depression (Nagel 2018)	0.2	0.3	0.5	0.7	0.6	0.7	-0.2	0.1
Intelligence (Savage-Jansen 2018)	0.5	1.4	5.3	0.2	-0.4	0.6	-2.3	1.0
Neuroticism (Nagel 2018)	0.3	0.8	3.0	-1.7	0.4	-0.8	0.2	-0.1
Schizophrenia (2018)	1.0	2.1	5.6	-2.0	-1.0	-2.4	-0.2	-0.0
Schizophrenia vs Biploar Disorder	0.4	0.5	1.4	0.5	0.9	-0.1	0.3	1.2
Worry (Nagel 2018)	1.9	4.0	12.3	-3.5	-1.1	-2.0	-1.3	0.6
Alzheimer’s Disease (in mother)	0.4	0.4	1.3	-0.1	1.2	-0.3	0.7	0.3
Alzheimer’s Disease (in father)	0.9	1.0	1.7	-1.3	1.2	-1.3	-0.2	-0.4
Alzheimer’s Disease (including proxy)	0.6	0.8	3.1	-0.4	1.8	-0.9	0.4	0.2
Crohns Disease (2017)	0.5	1.1	2.1	0.5	1.2	1.3	-0.1	1.4
Irritable Bowel Disease (IBD)	0.2	0.4	1.3	-0.1	1.1	-0.1	-0.0	0.7
Ulcerative Colitis (UC)	0.3	0.6	1.6	-0.7	1.0	-1.3	0.4	0.1
Major Depression (MDD)	0.2	0.3	0.9	0.1	-0.0	-0.1	0.6	-1.0
Reaction Time	2.3	4.4	6.8	2.6	0.8	1.9	2.5	2.2
Verbal and Numeric Reasoning (VNR)	0.8	1.8	4.2	-1.4	-0.8	-0.5	-2.0	1.4
Breast Cancer	0.2	0.5	1.2	-0.4	-0.8	0.0	-1.1	-0.5
Ovarian Cancer	0.3	0.4	1.6	-0.1	-0.3	0.4	-1.3	0.4
Prostate Cancer	1.4	2.0	4.8	1.3	0.4	2.2	-0.1	1.8
Age at First Birth	0.8	1.2	2.1	1.4	-1.2	1.5	0.1	0.8
Bipolar Disorder (2011)	1.4	1.3	4.9	0.0	-1.3	0.4	0.0	-2.2
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	0.4	0.4	-0.2	-0.7	-0.6
Coronary Artery Disease (CAD)	0.7	0.8	3.1	0.0	0.7	-0.8	1.8	-0.0
Crohns Disease (2012)	0.5	0.8	2.6	1.6	0.4	0.9	-0.4	0.4
Mean Putamen Volume	0.9	1.1	3.7	0.8	0.6	0.8	1.9	0.1
Fasting Glucose	0.5	0.6	2.1	0.0	0.5	0.6	1.4	-0.4
HbA1C	1.7	1.9	4.3	-1.3	-1.1	-2.1	-0.9	-1.2
HDL Cholesterol	0.1	0.2	0.6	-0.2	-0.2	0.8	-0.3	-0.6
LDL Cholesterol	0.8	1.3	3.2	0.2	1.7	-0.1	1.8	0.4
Lupus	1.5	2.3	9.5	0.8	-1.2	-0.0	-0.3	-3.1
Neuroticism (2016)	0.2	0.3	1.0	1.0	0.2	0.5	0.1	0.6
Primary Biliary Cirrhosis	1.1	1.6	5.2	2.3	0.5	1.6	0.5	0.2
Rheumatoid Arthritis	0.8	1.2	2.8	-0.8	-0.7	0.1	1.3	-1.7
Schizophrenia (2014)	2.1	4.5	9.7	-2.2	-2.3	-3.1	-0.9	-1.4
Triglycerides	0.3	0.5	0.7	-0.7	0.6	-0.8	-0.7	-0.8
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.8	-1.1	0.5	-0.6	1.4	-0.4
Ulcerative Colitis	0.3	0.4	0.7	0.7	0.4	-0.5	0.6	0.9
Blood Eosinophil Count	0.3	2.2	9.1	1.4	-0.4	0.3	0.2	-3.0
Blood Platelet Count	0.2	2.3	11.3	-0.1	-3.4	0.4	-0.2	0.5
Blood Red Count	0.0	0.2	0.8	0.2	-0.0	-0.9	-0.4	-0.2
Blood White Count	0.1	0.4	1.6	-0.6	-0.3	-0.2	-1.3	0.2
Heel T-Score	0.9	7.0	17.7	0.4	-3.2	-1.2	-2.3	-4.2
BMI	0.7	3.8	10.6	-1.6	1.3	-3.3	-1.1	-1.8
Height	1.0	20.1	54.8	3.1	-3.8	7.4	4.7	-0.4
Waist Hip Ratio (WHR)	0.6	2.6	8.5	0.2	1.9	-0.7	0.7	2.9
Systolic Blood Pressure	0.3	1.3	2.1	-1.1	0.5	-1.0	-1.3	-1.5
Smoking Status	0.4	1.0	2.4	-1.3	-0.2	-0.4	0.9	1.5
Allergy or Eczema	0.9	2.4	3.0	1.5	-1.6	1.7	1.2	1.6
Cardiovascular Disease	0.5	1.6	3.0	-1.0	1.0	-1.7	-1.0	-1.4
Hypothyroidism (self reported)	1.0	2.4	8.5	0.5	-1.3	-0.4	1.1	-2.9
Respiratory disease	0.6	1.3	3.0	0.2	-0.9	1.7	0.4	1.6
Type 2 Diabetes (T2D) (2018)	0.8	1.4	3.5	0.5	0.1	0.9	1.9	1.6
Lung FEV1/FVC ratio	0.8	4.1	15.8	-0.3	-0.4	-2.2	-4.0	0.2
Lung FVC	0.2	0.9	3.2	0.7	-1.8	0.7	-0.4	-0.2
Neuroticism	0.3	0.8	2.7	-1.6	0.3	-0.7	-1.0	-0.2
Chronotype (morning person)	1.3	3.1	6.7	-1.7	2.1	0.9	2.6	-0.7
Hair Pigment	0.1	3.8	6.7	-2.5	0.1	-0.6	2.6	2.4
Tanning	0.1	1.0	2.2	0.8	1.5	0.5	0.9	-1.0
Hand grip strength (left)	0.9	2.4	5.3	1.6	-1.7	2.3	0.9	-0.5
Number of treatments/medications taken	0.9	1.5	4.1	-0.5	-1.4	0.5	1.0	2.0
Average weekly spirits intake	0.8	1.0	3.0	-0.9	1.7	-0.3	1.0	0.2
Sensitivity / hurt feelings	0.4	0.7	1.5	0.5	0.8	0.7	-0.7	-1.2
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.9	-0.0	-0.5	0.0	-0.9	0.1
Hearing difficulty/problems: Yes	0.2	0.4	1.3	0.3	0.6	1.1	0.2	-0.0
Relative age of first facial hair	0.6	1.2	3.0	1.7	-0.5	1.6	0.1	-0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	-0.9	-0.9	0.3	-0.8	-0.1
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.6	-1.6	0.4	-1.6	1.3	0.9
Ever had hysterectomy (womb removed)	1.0	1.1	4.0	-2.0	0.4	-1.0	0.5	0.1
Systolic blood pressure, automated reading	0.7	1.9	4.4	-2.1	1.2	-1.6	-0.3	-1.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.8	-0.9	0.1	-0.5	-0.2	-0.3
Angina	0.6	0.8	1.7	-1.1	-1.3	-1.0	-0.4	0.1
Medication for hormone replacement therapy	0.4	0.4	0.8	0.6	0.6	0.1	0.9	0.7
Vitamin and mineral supplements	1.0	1.4	5.3	1.0	0.7	0.2	-0.2	-2.3
Supplements: Zinc	0.9	0.9	2.0	-0.3	-1.4	-0.5	-1.4	0.7
Medication: Co-codamol	1.5	1.8	4.1	-1.2	-1.2	-0.8	-2.0	1.1
Medication: Metformin	1.2	1.7	4.8	0.4	0.4	1.3	1.3	2.2
Diabetes (father)	0.3	0.3	1.2	-0.4	-0.2	-1.1	-0.3	-0.2
Diabetes (mother)	0.3	0.4	0.7	0.7	-0.8	-0.8	-0.4	-0.1
Severe depression (siblings)	0.7	0.8	2.5	-0.4	-1.6	0.4	-0.7	-0.7
Pack years adult smoking proportion	0.2	0.3	0.9	0.7	0.6	0.2	-0.1	0.9
Impedance of leg (right)	0.2	0.9	3.3	0.6	-1.8	0.2	0.0	0.9
Leg fat-free mass (left)	0.1	0.7	1.6	0.2	-0.5	1.0	0.9	-1.3
Trunk fat percentage	0.3	1.1	2.6	-1.5	0.7	-1.6	-0.2	0.4
Hand grip strength (right)	1.1	2.9	7.4	2.0	-0.2	2.7	1.4	1.0
Townsend deprivation index at recruitment	0.6	0.9	3.5	-1.9	0.3	-0.7	0.4	-0.1
Current tobacco smoking	0.2	0.4	1.6	-0.4	-0.1	0.2	0.3	1.2
Average weekly fortified wine intake	0.7	0.9	2.9	-1.0	-1.7	-0.4	-0.3	-0.5
Maternal smoking around birth	0.9	1.3	3.1	-0.7	-1.3	-0.8	-1.8	0.7
Fed-up feelings	0.5	0.9	1.2	-1.1	-0.3	-1.1	-1.0	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	0.0	-0.8	-0.1	-0.6	-0.1
Relative age voice broke	0.7	1.1	2.3	0.8	-0.8	1.5	-0.1	1.4
Taking other prescription medications	1.7	2.6	5.5	-0.3	-2.4	1.2	0.7	2.3
Age when periods started (menarche)	3.7	8.9	21.3	4.6	-0.8	4.3	1.8	0.9
Bilateral oophorectomy (both ovaries removed)	2.9	3.4	10.8	-3.3	0.4	-2.3	0.6	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	7.8	-0.3	-2.4	-0.9	-1.6	-2.8
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.5	-0.1	1.4	0.6	1.6	1.4
Qualifications: CSEs or equivalent	0.1	0.2	0.3	0.4	-0.3	-0.5	0.3	-0.4
Serious illness, injury or assault to yourself	0.6	0.7	1.9	-0.5	-1.4	0.0	-0.3	-1.1
High blood pressure	0.4	1.1	2.7	-0.9	0.4	-1.6	-1.2	0.5
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.6	1.2	-1.9	1.1	1.1	1.0
Multivitamins +/- minerals	0.9	1.2	3.0	-0.8	-1.4	0.2	-0.4	1.7
Stomach or abdominal pain in last month	0.3	0.3	0.5	0.6	-0.7	0.4	-0.6	-0.6
Supplements: Glucosamine	0.7	0.9	2.9	-0.5	0.9	-1.7	-0.8	-0.2
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.2	-1.2	-0.3	-1.8	-1.1	-0.2
Medication: Atenolol	0.5	0.6	1.7	-0.8	-1.3	-0.5	0.5	0.1
Medication: Levothyroxine sodium	1.0	1.6	6.1	0.4	0.4	0.1	1.3	-2.5
Sitting height	0.8	5.5	13.2	2.1	-2.2	3.6	0.8	-2.0
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	-0.9	-0.4	-0.5	-0.1	-0.4
High blood pressure (mother)	1.0	1.5	4.3	1.1	1.3	0.3	-2.1	0.1
Body mass index (BMI)	0.7	3.2	8.0	-2.2	1.4	-2.8	-0.5	-0.8
Impedance of leg (left)	0.2	0.8	2.3	0.2	-1.5	0.1	-0.6	1.2
Leg predicted mass (left)	0.1	0.8	1.5	0.2	-0.6	1.0	0.9	-1.2
Trunk fat mass	0.1	0.5	1.5	-1.2	0.2	-0.9	0.1	0.2
Waist circumference	0.4	1.6	4.4	-1.6	0.7	-2.1	-0.3	0.6
Number of incorrect matches in round	0.6	0.9	2.1	0.5	-1.4	0.2	1.0	-1.2
Past tobacco smoking	1.1	2.1	7.4	1.3	1.0	0.0	-0.3	-2.7
Alcohol usually taken with meals	0.6	0.9	2.2	1.2	-0.7	1.5	-0.1	-0.7
Nervous feelings	2.3	4.4	10.4	-3.2	-1.4	-3.0	-0.7	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.9	-0.3	-0.0	-1.0	-1.7	1.3
Hearing difficulty/problems with background noise	0.6	1.0	3.5	0.3	0.7	0.3	1.9	-0.9
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	1.0	0.2	0.5	-0.8	0.8
Had menopause	1.5	1.8	3.7	-1.9	1.1	-1.6	-1.2	-0.4
Had other major operations	1.0	1.2	5.3	-0.4	-0.2	0.3	-0.7	2.3
Forced vital capacity (FVC)	0.9	3.3	6.7	2.0	-2.3	2.6	0.9	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	4.4	0.3	-1.7	-0.5	-1.3	-2.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.2	-0.6	-0.4	-0.7	-0.2	1.5
Qualifications: None of the above	0.5	1.0	1.9	-1.2	0.2	-1.1	0.7	1.4
Financial difficulties in last 2 years	2.0	2.7	8.6	0.2	1.0	-0.5	-1.9	2.9
Mouth/teeth dental problems	0.6	1.0	2.1	1.4	1.5	0.4	0.0	0.7
Heart attack	1.7	2.2	5.2	0.8	-2.3	1.2	-0.4	1.9
Allergy	1.2	2.8	5.4	-1.6	1.5	-2.3	-0.7	-1.7
Pain all over the body in last month	0.2	0.2	0.5	0.5	-0.2	0.4	-0.7	-0.1
Diabetes (self-reported)	1.5	2.3	5.0	1.4	0.7	1.4	1.5	2.2
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	5.0	0.9	-1.4	2.2	0.8	0.7
Medication: Ramipril	0.1	0.2	0.6	-0.4	-0.7	-0.3	-0.1	0.2
Medication: Simvastatin	0.6	0.9	3.2	0.4	1.8	0.4	0.8	-0.4
Fluid intelligence score	1.0	2.1	3.2	-1.7	-1.4	-1.0	-1.8	1.0
Illnesses of siblings	2.2	3.1	8.7	1.0	-2.9	1.5	0.5	-1.9
Neuroticism score	0.3	0.7	2.1	-1.4	-0.2	-0.7	-0.8	0.0
Weight	0.1	0.3	0.9	-1.0	-0.3	-0.2	0.4	-0.6
Impedance of arm (right)	0.7	3.1	5.3	2.3	-0.3	2.3	1.1	2.0
Arm fat percentage (right)	0.5	1.9	4.6	-1.6	1.2	-2.1	-0.3	0.7
Trunk fat-free mass	0.4	2.3	3.5	0.6	-1.9	1.9	1.1	-1.8
Hip circumference	0.2	0.8	1.9	-1.4	-0.2	-1.1	0.7	-0.8
Time employed in main current job	0.5	0.6	1.9	-0.5	0.9	-1.4	-0.3	0.3
Alcohol intake versus 10 years previously	0.2	0.3	0.8	0.3	-0.9	-0.2	-0.8	-0.3
Father’s age at death	0.8	1.0	2.2	-0.6	-1.5	0.8	1.3	-0.7
Worrier / anxious feelings	0.2	0.4	0.9	-1.0	-0.8	0.3	-0.1	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	-0.0	-0.5	-0.0	-0.5	-0.8
Falls in the last year	0.1	0.2	0.5	0.4	0.3	0.4	0.7	-0.3
Hair/balding pattern: Pattern 3	1.6	2.4	5.4	-0.1	1.9	0.3	2.3	-1.7
Number of live births	0.2	0.3	0.6	0.2	0.8	-0.7	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.0	1.9	-2.0	1.6	-0.2	-0.4
Pulse rate	0.6	1.0	2.9	1.7	1.3	0.4	0.3	-0.4
Happiness	0.3	0.3	0.7	0.9	-0.6	0.3	-0.1	-0.7
Noisy workplace	0.5	0.6	1.2	0.6	-0.5	0.9	-0.4	1.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	-0.4	-0.8	-0.3	-1.0	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.6	0.6	1.1	1.6	1.2	1.4
Mouth/teeth dental problems: Dentures	1.4	2.3	5.9	-1.2	-2.4	-0.7	-1.4	-1.3
Asthma	1.2	2.4	7.7	0.8	-0.7	1.8	0.2	2.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.1	-0.5	0.8	-0.5	1.1	-0.8
Medication: Cholesterol lowering	1.6	2.5	6.6	0.8	0.1	2.6	2.0	1.2
Depression (self-reported)	1.4	1.7	5.9	1.0	-1.0	-0.6	-2.4	0.2
Medication: Lansoprazole	0.3	0.4	0.9	-0.0	-0.3	0.9	-0.0	1.0
Prospective memory result	0.4	0.4	0.9	-0.3	0.5	0.7	0.7	1.0
Lung cancer (father)	0.5	0.5	1.2	-0.4	-0.8	-1.1	-0.6	0.6
Illnesses of mother	1.2	1.4	3.8	0.2	0.5	0.3	1.9	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.3	1.4	-1.5	1.4	-0.4	-0.8
Pulse wave Arterial Stiffness index	0.7	0.8	2.7	0.3	-0.5	-0.4	-0.9	1.6
Impedance of arm (left)	0.6	2.9	5.0	2.1	0.4	2.2	1.4	1.7
Arm fat mass (right)	0.2	0.9	2.2	-1.3	0.6	-1.5	0.1	-0.1
Trunk predicted mass	0.4	2.2	3.6	0.6	-1.8	1.9	1.0	-1.6
Standing height	1.2	11.9	33.4	2.9	-3.5	5.8	2.3	0.4
Length of working week for main job	0.9	1.0	2.8	0.1	0.9	-1.1	-1.7	-0.2
Exposure to tobacco smoke at home	0.7	0.8	1.8	0.5	1.3	-0.7	0.1	-1.2
Breastfed as a baby	1.6	2.0	5.5	1.3	-1.1	1.2	2.4	-0.1
Tense / ‘highly strung’	0.1	0.2	0.4	-0.5	0.4	0.1	-0.3	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.0	-1.3	-1.7	-1.0	0.0	0.1
Hair/balding pattern: Pattern 4	0.3	0.8	3.3	-0.4	-1.8	0.5	0.4	-0.2
Birth weight of first child	2.1	3.8	9.2	3.0	-1.2	1.5	2.4	-0.7
Peak expiratory flow (PEF)	0.4	0.8	2.7	0.3	-0.8	-0.5	-1.6	-0.7
Pulse wave reflection index	1.0	1.2	5.7	-0.0	0.7	0.2	-0.0	2.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.5	0.9	0.7	0.5	-0.1	1.2
Loud music exposure frequency	0.5	0.6	1.7	0.3	-1.0	-0.2	-1.3	0.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.8	-0.6	-2.2	-0.4	-1.4	-1.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.5	-0.6	1.2	-1.2	1.0	-0.0
Blood clot in the leg (DVT)	0.2	0.3	0.8	-0.2	0.5	0.1	-0.4	0.9
Medication: Paracetamol	0.1	0.2	0.9	0.2	-1.0	0.3	0.1	-0.0
Headache pain in last month	0.4	0.7	3.2	-0.4	-1.8	0.3	0.4	0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.1	0.1	0.1	-1.1	-0.1	-0.8
Glaucoma (self-reported)	0.5	0.6	1.1	-0.9	-1.1	0.2	-0.9	-0.1
Gout (self-reported)	1.0	1.4	4.1	0.3	0.4	0.5	1.5	2.0
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	9.6	-0.3	-0.6	-1.0	0.3	-3.1
Medication: Amlodipine	0.8	1.1	2.7	0.6	-0.1	0.4	1.4	1.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	-0.5	0.1	-0.9	0.0	0.2
Birth weight	1.6	3.5	6.1	2.4	-2.5	2.3	0.4	-0.1
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.4	-0.7	0.8	-0.8	-1.8	-0.3
High blood pressure (siblings)	1.3	1.9	6.1	-0.8	2.5	-1.2	-0.8	0.7
Forced vital capacity (FVC), Best measure	0.6	2.4	4.7	1.7	-1.9	2.2	0.5	-0.5
Body fat percentage	0.5	2.0	5.7	-1.9	0.8	-2.4	-0.3	0.4
Leg fat percentage (right)	0.9	3.4	10.6	-2.3	0.6	-3.2	-0.7	0.5
Arm fat-free mass (right)	0.3	1.7	4.6	-0.2	-1.7	0.7	0.5	-2.1
Exposure to tobacco smoke outside home	0.6	0.8	3.4	0.3	0.5	0.4	0.6	1.8
Comparative body size at age 10	0.2	0.5	0.9	-0.6	1.0	-0.6	0.6	0.5
Number of full brothers	0.4	0.5	0.8	0.2	0.9	0.7	-0.7	0.7
Worry too long after embarrassment	1.4	2.4	6.9	0.5	1.5	1.6	2.6	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.5	6.6	-2.6	-0.9	-2.0	-1.0	-0.4
Wheeze or whistling in the chest in last year	0.7	1.2	3.3	0.8	0.8	1.8	0.4	1.2
Number of children fathered	1.6	1.8	3.9	1.4	0.7	0.9	-2.0	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.4	-1.2	-0.4	-0.4	-0.2	-0.2
Age at first live birth	1.4	2.5	2.8	1.5	-1.6	1.6	1.7	-1.6
Pulse wave peak to peak time	0.7	0.8	2.5	-0.2	0.0	0.8	0.9	-1.6
Health satisfaction	0.3	0.4	1.0	0.7	-0.4	-0.2	-1.0	-0.6
Shortness of breath walking on level ground	0.5	0.6	2.0	0.4	1.4	-0.5	-0.5	0.7
Qualifications: College or University degree	0.5	1.6	3.6	1.9	-0.7	1.4	-0.9	-1.1
Eye problems/disorders: None of the above	0.5	0.5	0.9	0.7	1.0	0.7	-0.1	0.9
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.7	-1.0	-1.3	-0.4	-0.7	0.9
Emphysema/chronic bronchitis	1.1	1.2	4.0	-0.3	-0.9	1.0	0.5	-2.0
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	0.7	0.7	-0.1	-1.0	-0.1
Neck or shoulder pain in last month	0.6	0.9	3.6	-0.2	-1.9	0.7	0.6	0.0
Medication: Blood pressure	0.5	1.0	2.3	-0.1	-1.4	1.5	-0.0	0.8
Angina (self-reported)	0.5	0.6	1.5	-0.9	-1.2	-0.8	0.0	0.1
Migraine (self-reported)	0.4	0.5	2.1	1.4	0.2	0.4	-0.1	-0.2
Medication: Ibuprofen	0.5	0.6	2.3	0.7	0.1	0.2	0.4	-1.5
Medication: Allopurinol	1.2	1.6	4.0	1.0	-0.1	0.9	2.0	1.5
Medication: Omeprazole	0.5	0.6	1.8	-1.4	-0.2	-0.5	-0.8	0.4
Medication: Seretide 50 evohaler	0.2	0.2	0.6	0.3	-0.3	0.5	-0.1	0.7
Mean time to correctly identify matches	2.1	4.0	5.6	2.2	0.9	2.1	2.4	2.1
Heart disease (mother)	1.2	1.5	3.0	-0.2	-1.5	-0.6	-1.3	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	1.6	1.2	-1.3	0.9	-0.8	1.2
Whole body fat mass	0.2	1.0	2.5	-1.5	0.1	-1.6	0.1	0.2
Leg fat mass (right)	0.4	1.5	4.6	-1.6	0.2	-2.1	-0.2	0.2
Arm predicted mass (right)	0.3	1.5	4.2	-0.3	-1.6	0.7	0.6	-2.0
Pulse rate, automated reading	0.2	0.7	1.9	-0.6	0.5	-1.4	0.7	-0.5
Alcohol intake frequency.	0.7	1.6	3.6	-1.3	0.9	-1.9	-0.5	-1.2
Comparative height size at age 10	0.3	1.8	5.1	-0.0	-1.4	2.2	0.3	1.2
Number of full sisters	1.4	1.7	5.4	1.2	-0.1	0.9	-0.7	2.3
Suffer from ‘nerves’	2.4	3.7	5.8	-2.4	-1.4	-2.4	-1.6	1.6
Overall health rating	0.5	1.1	3.5	-1.3	-0.3	-0.2	1.9	0.1
Chest pain or discomfort	0.3	0.4	1.6	-0.4	-1.3	0.3	-0.4	0.2
Had major operations	1.0	1.2	4.9	-0.9	-2.2	0.0	0.4	-0.5
Age at last live birth	0.9	1.3	2.7	1.1	-1.2	1.6	1.0	-0.1
Family relationship satisfaction	0.3	0.4	1.1	-1.1	0.3	-0.1	-0.5	-0.8
Leg pain on walking	0.5	0.6	1.4	0.0	0.5	-1.1	-1.2	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.9	-0.5	-0.7	0.3	-1.4	0.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.9	-0.3	1.4	-1.3	-0.4	0.8
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	6.2	1.6	-0.8	1.5	1.3	-2.5
Medication: Aspirin	0.4	0.6	1.0	-0.9	-0.7	-0.3	1.0	0.5
Supplements: Vitamin C	1.6	1.9	3.5	-1.6	0.2	-1.9	0.7	1.7
Knee pain experienced in last month	0.6	0.9	2.3	-1.5	1.0	-0.6	0.7	0.7
Hypertension (Self-reported)	0.3	0.9	1.7	-0.7	0.6	-1.3	-1.1	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.0	-0.4	-0.6	0.5	-1.0	0.4
Illnesses of father: Heart disease	1.2	1.6	4.9	-2.2	-0.3	-1.5	-0.1	-0.8
Illnesses of siblings: Diabetes	0.6	0.7	1.9	0.3	0.8	-0.3	0.8	1.4
Smoking status: Previous	0.7	1.0	2.6	-1.1	-1.1	-0.2	0.0	1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	6.3	0.8	-2.5	2.5	-0.5	-0.3
Whole body fat-free mass	0.3	1.6	3.0	0.3	-1.4	1.5	1.0	-1.7
Leg fat-free mass (right)	0.1	0.7	1.5	0.2	-0.3	1.2	0.8	-1.2
Arm fat percentage (left)	0.4	1.8	3.7	-1.5	1.6	-1.9	-0.1	0.3
Average weekly red wine intake	0.6	0.8	1.7	0.9	1.3	0.9	0.5	-0.7
Handedness (chirality/laterality): Left-handed	1.2	1.5	4.5	-2.1	-1.5	-0.5	-0.6	0.3
Mood swings	0.3	0.6	1.5	-1.2	0.2	-0.4	0.1	-1.1
Loneliness, isolation	0.6	0.8	1.5	1.2	-0.8	1.1	-0.9	0.2
Long-standing illness, disability or infirmity	0.6	0.9	2.0	-1.4	-1.1	0.0	0.7	1.0
Ever had bowel cancer screening	0.8	0.9	2.8	-0.5	1.7	-0.0	1.0	-0.7
Diabetes diagnosed by doctor	1.8	3.0	7.6	0.4	1.2	1.3	2.0	2.8
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.4	-1.0	0.7	-1.2	0.7	0.1
Friendships satisfaction	0.2	0.2	0.7	-0.9	-0.3	0.1	-0.0	-0.5
Qualifications: nursing, teaching	0.9	1.4	3.5	1.5	0.7	1.9	-0.2	0.9
Commuting to job workplace: Walk	0.4	0.4	0.9	0.9	-0.2	0.4	1.0	0.4
Eye problems/disorders: Cataract	0.4	0.5	1.4	-0.2	-1.0	-0.3	0.2	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.5	-0.1	-1.6	1.1	0.9	0.6
Medication for cholesterol	0.5	0.8	2.6	-0.7	-1.6	0.6	-0.3	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	-0.5	0.9	0.0	1.3	0.6
Back pain experienced in last month	2.5	3.6	6.6	-2.3	-2.6	-0.6	-0.6	2.4
Mineral and other dietary supplements	0.7	0.9	2.8	0.9	0.4	0.8	-0.3	-1.7
Breast cancer (self-reported)	0.9	1.1	2.7	1.6	-0.6	1.0	-0.2	-1.2
Asthma (self-reported)	1.3	2.6	7.8	0.8	-0.9	1.9	0.4	2.8
Osteoporosis (self-reported)	0.9	1.1	4.9	-0.4	-0.1	0.2	-0.3	2.2
Osteoarthritis (self-reported)	2.0	2.6	4.9	-2.0	0.1	-2.2	0.3	-1.9
Medication: Aspirin	0.2	0.3	0.7	-0.8	-0.3	-0.1	0.8	0.2
Medication: Gliclazide	2.8	3.1	5.2	1.3	1.2	1.8	2.3	2.0
Illnesses of father: None of the above (group 1)	1.7	2.2	5.7	2.1	0.1	2.4	0.8	0.1
Smoking status: Current	0.2	0.3	1.4	-0.5	-0.1	-0.1	-0.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.7	2.0	1.4	-0.4	0.4	-0.9	-0.7
Whole body water mass	0.3	1.6	3.1	0.2	-1.4	1.3	0.9	-1.8
Leg predicted mass (right)	0.1	0.7	1.6	0.2	-0.2	1.1	0.8	-1.3
Arm fat mass (left)	0.3	1.1	2.5	-1.5	0.6	-1.6	0.1	-0.1
Number of self-reported non-cancer illnesses	0.4	0.6	2.2	-0.4	-0.4	0.4	0.5	1.5
Average weekly champagne plus white wine intake	0.4	0.5	1.0	0.9	-0.5	0.6	-0.1	-1.0
Miserableness	0.1	0.2	0.5	-0.7	-0.4	0.1	-0.4	0.0
Guilty feelings	1.0	1.5	4.3	0.7	1.6	-0.2	2.1	-0.2
Wears glasses or contact lenses	1.2	1.4	3.1	-0.9	-1.3	-1.2	-1.8	0.5
Ever taken oral contraceptive pill	0.5	0.5	1.6	0.3	0.9	1.3	-0.2	0.3
Hearing aid user	0.4	0.4	0.9	0.8	0.7	0.3	0.4	-0.9
Mother’s age at death	0.4	0.5	1.8	0.1	0.5	0.5	1.3	0.1
Financial situation satisfaction	2.0	2.5	4.8	2.2	1.0	2.2	-0.4	1.4
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.4	1.5	0.5	0.4	-1.2	-0.7
Commuting to job workplace: Public transport	1.3	1.5	3.7	1.9	-0.6	0.9	1.0	-1.3
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-1.1	-1.1	-0.1	-0.4	-0.6
Medication: Blood pressure	0.2	0.4	1.0	0.5	0.7	-1.0	-0.1	0.6
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.8	-1.4	-0.7	-0.8	-0.5	1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.5	-1.0	-0.5	-0.8	0.3	1.2
High cholesterol (Self-reported)	0.2	0.3	0.6	-0.8	-0.4	0.1	-0.5	-0.7
Medication: Bendroflumethiazide	0.1	0.1	0.4	0.0	-0.1	0.3	0.6	0.2
Medication: Paracetamol	0.3	0.5	1.6	0.1	-1.2	0.6	-0.6	0.4
Medication: Lisinopril	1.0	1.3	4.4	-0.7	-0.2	-0.6	-1.2	2.1
Medication: Atorvastatin	0.7	0.8	2.7	-0.0	-1.7	1.0	-0.6	0.4
Illnesses of father: High blood pressure	0.8	1.0	3.3	1.8	0.9	0.9	0.1	0.6
Alcohol drinker status: Never	1.9	2.3	4.5	-0.9	1.7	-2.1	-0.9	-1.5
Ever smoked	1.7	3.0	11.7	-0.9	-1.3	0.5	0.7	3.4
Basal metabolic rate	0.2	1.0	2.2	-0.1	-1.1	1.0	0.8	-1.5
Leg fat percentage (left)	1.1	4.0	10.9	-2.6	0.8	-3.3	-1.1	0.5
Arm fat-free mass (left)	0.2	1.1	2.8	-0.3	-1.4	0.4	0.5	-1.7
Number of operations (self-reported)	0.7	1.1	2.4	-1.3	-1.6	-0.2	-0.9	0.4
Average weekly beer plus cider intake	0.1	0.2	0.5	-0.1	0.4	-0.3	-0.7	-0.2
Irritability	0.4	0.7	2.1	-1.2	0.5	0.0	1.4	-0.2
Risk taking	0.3	0.4	0.9	0.8	0.2	0.1	-1.0	0.5
Ever had prostate specific antigen (PSA) test	1.1	1.2	2.6	-1.3	-0.4	-1.3	-1.6	0.3
Fractured/broken bones in last 5 years	0.0	0.1	0.1	0.2	-0.3	-0.0	-0.3	0.2
Age started oral contraceptive pill	0.7	0.8	1.7	1.3	-0.6	1.1	0.9	-0.1
Diastolic blood pressure, automated reading	1.0	3.0	5.3	-2.3	1.5	-2.1	-1.0	-1.5
Ever depressed for a whole week	0.1	0.2	0.7	-0.2	-0.1	-0.4	-0.8	0.2
Unable to work because of sickness or disability	0.6	0.7	2.0	0.7	0.2	-0.5	-1.4	-1.0
Commuting to job workplace: Cycle	2.8	3.3	7.9	1.5	-1.5	2.8	-0.9	-1.9
Myopia	0.7	1.1	3.4	0.2	-0.9	-1.1	-1.8	0.2
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.6	1.1	0.1	1.9	1.2	-0.3
Cholesterol lowering medication	0.4	0.5	2.1	0.6	1.4	0.1	-0.4	0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	-0.7	0.7	0.1	-0.3	0.2
Pain experienced in last month	0.6	1.0	2.0	0.7	1.2	-1.4	0.0	-1.1
Supplements: Calcium	3.9	4.3	16.9	-0.7	-1.7	0.4	-1.1	4.1
Basal cell carcinoma (self-reported)	1.6	1.9	8.5	-2.9	0.5	-1.0	-0.1	-0.1
Heart attack/myocardial infarction (self-reported)	1.7	2.2	4.7	0.8	-2.2	1.2	-0.2	2.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.6	-0.3	0.3	-0.1	-0.7	0.8
Heart disease (siblings)	2.4	2.9	4.7	-2.1	2.2	-1.7	1.6	-0.1
Alcohol drinker status: Previous	0.9	1.1	4.8	-0.5	2.2	0.1	-0.5	-0.1
Pack years of smoking	0.1	0.1	0.3	0.6	0.3	0.2	-0.1	0.5
Impedance of whole body	0.3	1.5	2.9	1.4	-0.5	1.5	0.6	1.7
Leg fat mass (left)	0.4	1.7	4.5	-1.9	0.3	-2.1	-0.6	0.2
Arm predicted mass (left)	0.3	1.3	3.0	-0.5	-1.7	0.2	0.4	-1.7