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chr5:136,994,893-141,714,291

Best TWAS P=1.19e-13 · Best GWAS P=3.45e-21 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	GTEx	Cells EBV-transformed lymphocytes	DNAJC18	0.26	0.09	lasso	2	0.12	9.7e-05	5.6	7.4	1.2e-13	0.75	0.04	0.86	TRUE
26	GTEx	Cells Transformed fibroblasts	CD14	0.09	0.05	lasso	4	0.06	2.7e-05	-5.8	-6.2	4.2e-10	-0.01	0.02	0.97	TRUE
88	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	BRD8	0.12	0.07	lasso	4	0.05	1.2e-03	6.0	-6.2	6.3e-10	0.01	0.00	0.98	TRUE
90	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SRA1	0.09	0.05	blup	29	0.05	1.1e-03	-5.9	5.6	1.6e-08	0.03	0.01	0.96	TRUE
21	GTEx	Breast Mammary Tissue	PCDHB10	0.32	0.15	lasso	8	0.18	2.4e-09	5.3	-5.5	3.4e-08	-0.06	0.01	0.99	TRUE
23	GTEx	Breast Mammary Tissue	PCDHB16	0.47	0.22	lasso	3	0.35	1.2e-18	4.8	-5.4	5.1e-08	-0.03	0.02	0.98	TRUE
12	GTEx	Artery Aorta	PCDHGB7	0.13	0.01	enet	17	0.03	1.4e-02	4.9	-5.4	5.6e-08	0.04	0.09	0.24	TRUE
52	GTEx	Pituitary	PCDHB12	0.29	0.15	lasso	5	0.23	1.4e-06	4.8	5.4	6.0e-08	0.01	0.05	0.90	TRUE
40	GTEx	Heart Left Ventricle	DNAJC18	0.18	0.16	enet	4	0.19	2.2e-10	5.6	5.3	9.9e-08	0.58	1.00	0.00	TRUE
28	GTEx	Cells Transformed fibroblasts	HDAC3	0.12	0.01	enet	57	0.02	1.8e-02	1.7	-5.3	1.2e-07	-0.01	0.04	0.65	TRUE
61	GTEx	Uterus	PCDHB16	0.38	0.03	enet	14	0.06	2.7e-02	5.3	-5.3	1.2e-07	-0.01	0.02	0.77	TRUE
63	ROSMAP	Brain Pre-frontal Cortex	APBB3	0.04	0.01	blup	218	0.01	9.7e-03	-5.7	-5.3	1.5e-07	0.02	0.02	0.94	TRUE
37	GTEx	Heart Atrial Appendage	PCDHB10	0.22	0.10	lasso	2	0.13	2.6e-06	-4.0	-5.2	2.1e-07	-0.07	0.05	0.92	TRUE
34	GTEx	Esophagus Muscularis	DNAJC18	0.22	0.10	lasso	6	0.13	3.2e-08	5.6	7.4	1.5e-13	0.58	0.54	0.13	FALSE
87	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBE2D2	0.05	0.02	enet	6	0.03	4.4e-04	5.1	7.4	1.5e-13	0.89	0.01	0.97	FALSE
35	GTEx	Esophagus Muscularis	TMEM173	0.24	0.00	lasso	6	0.06	1.5e-04	5.0	-6.6	3.0e-11	-0.54	0.69	0.15	FALSE
30	GTEx	Colon Transverse	DNAJC18	0.37	-0.01	lasso	5	0.01	1.1e-01	5.6	6.5	6.8e-11	0.58	0.06	0.07	FALSE
55	GTEx	Spleen	DNAJC18	0.30	0.13	lasso	5	0.20	6.5e-06	5.6	6.5	9.0e-11	0.76	0.10	0.66	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DNAJC18	0.09	0.10	bslmm	260	0.10	2.5e-12	4.0	6.4	1.9e-10	0.63	1.00	0.00	FALSE
31	GTEx	Esophagus Gastroesophageal Junction	DNAJC18	0.17	0.01	lasso	10	0.04	2.0e-02	5.4	6.2	4.3e-10	0.75	0.07	0.62	FALSE
80	The Cancer Genome Atlas	Colon Adenocarcinoma	TMCO6	0.08	0.06	enet	8	0.07	1.2e-04	-5.4	-6.1	8.6e-10	-0.03	0.01	0.98	FALSE
92	The Cancer Genome Atlas	Lung Adenocarcinoma	CD14	0.03	0.01	blup	38	0.02	1.6e-03	-5.4	-6.1	8.9e-10	-0.03	0.02	0.62	FALSE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIF20A	0.01	0.00	blup	27	0.01	1.4e-02	-4.2	6.0	1.6e-09	0.03	0.01	0.38	FALSE
18	GTEx	Artery Tibial	PROB1	0.06	0.09	enet	10	0.08	5.9e-07	5.6	-6.0	2.1e-09	-0.60	0.78	0.17	FALSE
85	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC35A4	0.02	0.02	lasso	3	0.01	3.5e-02	-5.8	6.0	2.4e-09	0.03	0.00	0.84	FALSE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM173	0.02	0.03	blup	7	0.03	4.6e-07	5.3	-6.0	2.5e-09	-0.55	0.02	0.98	FALSE
32	GTEx	Esophagus Mucosa	DNAJC18	0.22	0.17	lasso	2	0.16	5.1e-11	5.6	6.0	2.6e-09	0.56	1.00	0.00	FALSE
56	GTEx	Testis	CD14	0.13	0.10	lasso	7	0.13	3.2e-06	-5.9	-5.9	2.8e-09	-0.03	0.02	0.98	FALSE
58	GTEx	Thyroid	DNAJC18	0.38	0.26	lasso	4	0.26	1.5e-19	5.6	5.9	3.5e-09	0.57	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CD14	0.10	0.01	blup	343	0.05	1.0e-06	-5.3	-5.9	3.8e-09	0.02	0.10	0.83	FALSE
27	GTEx	Cells Transformed fibroblasts	DNAJC18	0.28	0.14	lasso	5	0.11	1.4e-08	5.6	5.9	3.9e-09	0.57	0.99	0.01	FALSE
41	GTEx	Heart Left Ventricle	SRA1	0.10	0.07	lasso	13	0.08	6.3e-05	-5.7	5.9	4.3e-09	0.00	0.02	0.97	FALSE
73	The Cancer Genome Atlas	Breast Invasive Carcinoma	DNAJC18	0.09	0.06	lasso	5	0.05	1.1e-10	5.6	5.9	4.4e-09	0.56	0.02	0.98	FALSE
86	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SRA1	0.08	0.06	lasso	2	0.05	1.3e-06	-5.8	5.9	4.6e-09	0.03	0.00	1.00	FALSE
107	The Cancer Genome Atlas	Thyroid Carcinoma	DNAJC18	0.08	0.10	blup	23	0.10	3.7e-10	5.1	5.8	5.0e-09	0.61	0.06	0.94	FALSE
94	The Cancer Genome Atlas	Lung Adenocarcinoma	WDR55	0.03	0.02	blup	44	0.03	5.2e-04	-5.4	-5.8	5.2e-09	-0.02	0.01	0.91	FALSE
72	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD14	0.01	0.01	blup	38	0.00	3.5e-02	4.1	-5.8	6.1e-09	-0.02	0.01	0.45	FALSE
54	GTEx	Skin Sun Exposed Lower leg	DNAJC18	0.09	0.06	enet	5	0.06	1.7e-05	5.6	5.8	6.4e-09	0.57	0.67	0.10	FALSE
49	GTEx	Ovary	DNAJC18	0.33	0.24	lasso	3	0.21	7.1e-06	5.6	5.8	6.5e-09	0.57	0.08	0.09	FALSE
77	The Cancer Genome Atlas	Colon Adenocarcinoma	CD14	0.11	0.06	enet	5	0.07	8.6e-05	-5.8	-5.8	6.5e-09	-0.01	0.00	0.97	FALSE
79	The Cancer Genome Atlas	Colon Adenocarcinoma	DND1	0.04	0.02	blup	47	0.04	3.4e-03	-4.5	-5.8	8.4e-09	-0.02	0.02	0.69	FALSE
76	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DNAJC18	0.06	0.05	lasso	2	0.04	7.3e-03	5.6	5.8	8.6e-09	0.57	0.01	0.64	FALSE
44	GTEx	Muscle Skeletal	DNAJC18	0.44	0.33	lasso	7	0.34	5.5e-34	5.6	5.7	9.4e-09	0.59	1.00	0.00	FALSE
16	GTEx	Artery Tibial	TMEM173	0.24	0.14	lasso	3	0.13	1.2e-10	5.5	-5.7	9.5e-09	-0.43	1.00	0.00	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	KDM3B	0.07	0.01	blup	307	0.03	1.0e-04	4.7	-5.7	1.1e-08	-0.08	0.34	0.45	FALSE
43	GTEx	Lung	PROB1	0.15	0.12	lasso	11	0.10	2.2e-08	5.6	-5.7	1.2e-08	-0.57	0.98	0.01	FALSE
93	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJC18	0.09	0.10	lasso	3	0.09	1.9e-10	5.6	5.7	1.4e-08	0.57	0.02	0.98	FALSE
106	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SRA1	0.21	0.13	blup	30	0.14	1.3e-05	-5.6	5.7	1.4e-08	0.01	0.01	0.98	FALSE
84	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DNAJC18	0.10	0.07	blup	24	0.07	2.3e-08	5.6	5.7	1.5e-08	0.57	0.03	0.97	FALSE
108	The Cancer Genome Atlas	Thyroid Carcinoma	EIF4EBP3	0.04	0.00	enet	4	0.01	1.6e-02	-5.9	-5.7	1.5e-08	-0.04	0.00	0.89	FALSE
51	GTEx	Pancreas	DNAJC18	0.42	0.32	lasso	2	0.28	1.7e-12	5.6	5.6	1.7e-08	0.56	1.00	0.00	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	DNAJC18	0.08	0.10	lasso	3	0.09	2.2e-11	5.6	5.6	1.8e-08	0.57	1.00	0.00	FALSE
9	GTEx	Adrenal Gland	DNAJC18	0.30	0.25	lasso	2	0.23	8.1e-09	5.6	5.6	1.9e-08	0.56	0.74	0.14	FALSE
89	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EIF4EBP3	0.04	0.03	lasso	1	0.02	1.6e-02	-5.6	-5.6	1.9e-08	0.00	0.01	0.88	FALSE
91	The Cancer Genome Atlas	Brain Lower Grade Glioma	EIF4EBP3	0.04	0.04	blup	28	0.04	1.1e-05	-5.6	-5.6	2.0e-08	-0.03	0.01	0.99	FALSE
78	The Cancer Genome Atlas	Colon Adenocarcinoma	DNAJC18	0.14	0.12	lasso	2	0.11	7.3e-07	5.6	5.6	2.1e-08	0.56	0.02	0.98	FALSE
33	GTEx	Esophagus Mucosa	TMEM173	0.10	0.03	enet	20	0.10	1.8e-07	7.5	-5.6	2.2e-08	-0.39	0.16	0.23	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	CD14	0.03	0.02	blup	206	0.01	2.0e-02	-5.4	-5.6	2.3e-08	-0.02	0.02	0.95	FALSE
38	GTEx	Heart Atrial Appendage	DNAJC18	0.31	0.28	lasso	3	0.25	1.3e-11	5.6	5.6	2.4e-08	0.56	1.00	0.00	FALSE
14	GTEx	Artery Tibial	DNAJC18	0.07	0.08	lasso	2	0.06	2.3e-05	5.6	5.6	2.6e-08	0.56	0.78	0.07	FALSE
95	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DNAJC18	0.06	0.03	enet	5	0.03	1.3e-04	5.6	5.6	2.6e-08	0.45	0.02	0.91	FALSE
97	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	DNAJC18	0.06	0.02	blup	23	0.02	9.5e-03	5.6	5.6	2.7e-08	0.59	0.02	0.62	FALSE
69	YFS	Blood	SLC35A4	0.05	0.05	bslmm	313	0.05	9.7e-17	-5.6	5.6	2.8e-08	0.00	0.02	0.98	FALSE
29	GTEx	Cells Transformed fibroblasts	TMEM173	0.19	0.17	lasso	1	0.17	1.7e-12	5.5	-5.5	3.5e-08	-0.46	1.00	0.00	FALSE
59	GTEx	Thyroid	TMEM173	0.09	0.10	lasso	1	0.09	1.8e-07	5.5	-5.5	3.5e-08	-0.46	0.89	0.05	FALSE
82	The Cancer Genome Atlas	Glioblastoma Multiforme	TMEM173	0.13	0.12	lasso	2	0.12	2.0e-04	5.5	-5.5	3.5e-08	-0.46	0.01	0.54	FALSE
83	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM173	0.02	0.02	lasso	2	0.02	1.5e-03	5.5	-5.5	3.5e-08	-0.46	0.01	0.40	FALSE
104	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM173	0.04	0.04	lasso	2	0.04	6.7e-04	5.5	-5.5	3.5e-08	-0.46	0.02	0.68	FALSE
24	GTEx	Breast Mammary Tissue (Male)	PCDHB16	0.43	0.24	enet	8	0.22	7.8e-06	4.8	-5.5	4.0e-08	-0.04	0.02	0.96	FALSE
68	ROSMAP	Brain Pre-frontal Cortex	EIF4EBP3	0.05	0.06	lasso	4	0.06	1.9e-08	-5.3	-5.5	4.4e-08	-0.04	0.03	0.97	FALSE
20	GTEx	Brain Cerebellum	PCDHB10	0.27	0.24	enet	9	0.23	1.8e-07	4.8	-5.5	4.5e-08	-0.04	0.02	0.98	FALSE
81	The Cancer Genome Atlas	Colon Adenocarcinoma	WDR55	0.09	0.08	enet	12	0.12	1.5e-07	-4.4	-5.5	4.5e-08	0.01	0.13	0.84	FALSE
103	The Cancer Genome Atlas	Skin Cutaneous Melanoma	DNAJC18	0.46	0.00	blup	24	0.06	1.4e-02	-2.0	5.5	4.5e-08	0.42	0.00	0.55	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM173	0.04	0.04	lasso	3	0.04	2.1e-04	5.4	-5.5	4.5e-08	-0.46	0.02	0.91	FALSE
36	GTEx	Esophagus Muscularis	PCDHB16	0.38	0.22	lasso	8	0.24	5.3e-15	5.3	-5.4	5.1e-08	0.02	0.04	0.96	FALSE
6	CommonMind	Brain Pre-frontal Cortex	SPATA24	0.05	0.03	lasso	3	0.04	1.4e-05	5.0	5.4	5.2e-08	0.52	0.54	0.03	FALSE
57	GTEx	Thyroid	PCDHB10	0.13	0.06	lasso	2	0.11	6.9e-09	5.3	-5.4	6.0e-08	-0.05	0.03	0.97	FALSE
71	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	WDR55	0.07	0.00	enet	9	0.02	1.6e-02	-5.3	-5.4	6.0e-08	-0.03	0.00	0.91	FALSE
45	GTEx	Muscle Skeletal	PCDHB16	0.19	0.12	lasso	3	0.12	7.2e-12	4.8	-5.4	6.2e-08	-0.01	0.17	0.82	FALSE
100	The Cancer Genome Atlas	Prostate Adenocarcinoma	DNAJC18	0.24	0.19	enet	13	0.21	1.1e-21	5.6	5.4	6.2e-08	0.51	0.02	0.98	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	PROB1	0.12	0.09	lasso	6	0.10	7.7e-13	5.6	-5.4	6.3e-08	-0.61	1.00	0.00	FALSE
105	The Cancer Genome Atlas	Stomach Adenocarcinoma	WDR55	0.04	0.01	blup	45	0.03	3.7e-03	4.1	-5.4	6.5e-08	-0.01	0.04	0.38	FALSE
11	GTEx	Artery Aorta	TMEM173	0.35	0.16	enet	5	0.15	9.8e-09	5.5	-5.4	6.7e-08	-0.45	0.99	0.00	FALSE
39	GTEx	Heart Left Ventricle	PCDHB12	0.21	0.07	lasso	5	0.15	1.7e-08	-4.0	5.4	7.2e-08	0.07	0.11	0.88	FALSE
98	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	NDUFA2	0.03	0.02	blup	42	0.04	1.1e-03	4.0	5.4	7.4e-08	0.02	0.06	0.24	FALSE
47	GTEx	Nerve Tibial	PCDHB16	0.48	0.34	lasso	8	0.41	4.7e-31	4.8	-5.4	7.7e-08	-0.03	0.18	0.81	FALSE
10	GTEx	Artery Aorta	PCDHB9	0.21	0.06	enet	24	0.14	4.2e-08	5.3	-5.4	8.0e-08	-0.03	0.04	0.95	FALSE
7	CommonMind	Brain Pre-frontal Cortex	SRA1	0.16	0.15	lasso	7	0.19	4.3e-22	4.2	5.4	8.1e-08	-0.01	0.44	0.56	FALSE
62	METSIM	Adipose	SRA1	0.08	0.06	lasso	3	0.09	8.7e-13	-5.4	5.3	9.7e-08	0.01	0.04	0.96	FALSE
4	CommonMind	Brain Pre-frontal Cortex	PCDHB10	0.13	0.11	lasso	4	0.13	3.0e-15	-3.9	-5.3	1.0e-07	-0.08	0.13	0.86	FALSE
13	GTEx	Artery Coronary	PCDHB10	0.15	0.07	enet	12	0.12	6.1e-05	4.7	-5.3	1.0e-07	-0.05	0.04	0.93	FALSE
17	GTEx	Artery Tibial	PCDHB16	0.38	0.32	lasso	9	0.36	2.7e-29	4.8	-5.3	1.1e-07	0.01	0.19	0.80	FALSE
5	CommonMind	Brain Pre-frontal Cortex	PCDHB16	0.09	0.06	blup	443	0.08	1.1e-09	4.3	-5.3	1.2e-07	-0.03	0.02	0.98	FALSE
42	GTEx	Lung	PCDHB16	0.26	0.21	lasso	8	0.22	6.5e-17	4.8	-5.3	1.3e-07	0.01	0.11	0.88	FALSE
60	GTEx	Thyroid	PCDHB16	0.31	0.24	lasso	6	0.30	2.5e-23	4.8	-5.3	1.3e-07	-0.02	0.21	0.78	FALSE
15	GTEx	Artery Tibial	PCDHB9	0.24	0.09	lasso	6	0.16	1.4e-12	4.7	-5.3	1.4e-07	-0.05	0.08	0.92	FALSE
53	GTEx	Skin Sun Exposed Lower leg	PCDHB10	0.20	0.08	lasso	9	0.12	3.3e-10	5.3	-5.3	1.4e-07	-0.04	0.05	0.94	FALSE
101	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC23A1	0.09	0.15	lasso	3	0.14	7.9e-15	5.1	5.3	1.4e-07	0.58	0.02	0.98	FALSE
102	The Cancer Genome Atlas	Prostate Adenocarcinoma	WDR55	0.07	0.06	blup	44	0.06	1.7e-06	-4.4	-5.3	1.4e-07	-0.02	0.23	0.74	FALSE
8	GTEx	Adipose Subcutaneous	PCDHB16	0.36	0.27	lasso	8	0.28	6.7e-23	4.8	-5.2	2.2e-07	0.00	0.21	0.78	FALSE
3	CommonMind	Brain Pre-frontal Cortex	IK	0.03	0.02	lasso	6	0.03	6.0e-05	-4.5	-5.2	2.4e-07	0.01	0.54	0.34	FALSE
46	GTEx	Nerve Tibial	PCDHB9	0.20	0.06	lasso	5	0.09	7.5e-07	-4.0	-5.2	2.4e-07	-0.08	0.20	0.79	FALSE
48	GTEx	Nerve Tibial	PROB1	0.08	0.08	lasso	2	0.08	3.7e-06	5.6	-5.2	2.4e-07	-0.53	0.26	0.07	FALSE
50	GTEx	Ovary	PCDHB16	0.30	0.33	lasso	3	0.34	4.7e-09	5.3	-5.2	2.5e-07	0.02	0.04	0.94	FALSE
96	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SPATA24	0.02	0.02	enet	2	0.01	1.2e-02	5.0	5.1	2.7e-07	0.57	0.03	0.37	FALSE
19	GTEx	Brain Cerebellar Hemisphere	PCDHB10	0.43	0.17	enet	20	0.24	9.8e-07	5.3	-5.1	2.8e-07	-0.07	0.02	0.97	FALSE
70	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DNAJC18	0.03	0.02	blup	22	0.02	6.9e-03	5.6	5.1	2.8e-07	0.59	0.02	0.57	FALSE
22	GTEx	Breast Mammary Tissue	PCDHB9	0.11	0.04	lasso	5	0.02	1.9e-02	4.8	-5.1	3.1e-07	-0.04	0.02	0.96	FALSE
99	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DNAJC18	0.07	0.09	blup	24	0.09	1.9e-04	5.6	5.1	3.1e-07	0.59	0.05	0.86	FALSE