Hub : Genes

TXNDC15

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1640 0.0520 1.0e-04 0.140 NA 0.096 NA 0.125 4.0e-08 NA 6.2e-06 NA 2.2e-07
2 GTEx Artery Tibial 0.0827 0.0281 4.3e-04 0.098 NA 0.091 NA 0.102 4.4e-08 NA 1.3e-07 NA 2.4e-08
3 GTEx Brain Cerebellar Hemisphere 0.5090 0.0880 3.4e-07 0.476 NA 0.407 NA 0.468 6.2e-14 NA 1.4e-11 NA 1.2e-13
4 GTEx Brain Cerebellum 0.4810 0.0830 9.0e-08 0.356 NA 0.454 NA 0.477 2.2e-11 NA 5.1e-15 NA 5.7e-16
5 GTEx Brain Putamen basal ganglia 0.3860 0.1180 2.2e-03 -0.013 NA 0.059 NA -0.009 9.1e-01 NA 1.6e-02 NA 6.1e-01
6 GTEx Breast Mammary Tissue 0.1290 0.0530 8.1e-03 -0.001 NA 0.058 NA 0.007 3.9e-01 NA 6.1e-04 NA 1.3e-01
7 GTEx Cells Transformed fibroblasts 0.3820 0.0590 1.7e-16 0.310 NA 0.326 NA 0.326 1.1e-23 NA 5.0e-25 NA 4.8e-25
8 GTEx Colon Sigmoid 0.1930 0.0630 1.5e-03 0.123 NA 0.061 NA 0.104 4.0e-05 NA 3.4e-03 NA 1.6e-04
9 GTEx Colon Transverse 0.2240 0.0700 1.0e-03 -0.006 NA -0.006 NA -0.005 8.2e-01 NA 8.1e-01 NA 6.8e-01
10 GTEx Esophagus Muscularis 0.1420 0.0460 1.0e-03 0.112 NA 0.094 NA 0.102 2.7e-07 NA 2.4e-06 NA 9.3e-07
11 GTEx Nerve Tibial 0.2564 0.0530 1.3e-09 0.168 NA 0.189 NA 0.196 6.1e-12 NA 2.3e-13 NA 6.9e-14
12 GTEx Pituitary 0.3230 0.1010 9.8e-04 0.180 NA 0.170 NA 0.228 2.8e-05 NA 4.6e-05 NA 1.9e-06
13 GTEx Skin Not Sun Exposed Suprapubic 0.1860 0.0590 1.8e-04 0.157 NA 0.114 NA 0.110 6.0e-09 NA 8.6e-07 NA 1.2e-06
14 GTEx Skin Sun Exposed Lower leg 0.1390 0.0370 5.0e-06 0.086 NA 0.151 NA 0.170 1.2e-07 NA 1.6e-12 NA 5.3e-14
15 GTEx Thyroid 0.2430 0.0530 4.9e-09 0.217 NA 0.239 NA 0.236 1.4e-16 NA 3.0e-18 NA 4.8e-18
16 METSIM Adipose 0.0447 0.0167 8.6e-04 0.050 0.016 0.032 0.024 0.039 5.6e-08 1.7e-03 1.2e-05 1.3e-04 1.4e-06
17 NTR Blood 0.0542 0.0151 8.6e-08 0.050 0.029 0.043 0.046 0.048 1.1e-15 1.1e-09 8.6e-14 1.7e-14 2.7e-15
18 ROSMAP Brain Pre-frontal Cortex 0.1940 0.0386 6.1e-15 0.103 0.138 0.105 0.140 0.108 3.6e-13 2.2e-17 2.4e-13 1.2e-17 1.0e-13
19 YFS Blood 0.0938 0.0191 0.0e+00 0.054 0.085 0.102 0.093 0.106 3.3e-17 1.7e-26 1.4e-31 9.9e-29 7.0e-33
20 TCGA Breast Invasive Carcinoma 0.0496 0.0188 2.9e-08 0.058 0.046 0.051 NA 0.055 5.4e-12 8.5e-10 9.4e-11 NA 1.9e-11
21 TCGA Colon Adenocarcinoma 0.1300 0.0550 5.0e-05 0.081 0.087 0.049 NA 0.064 2.1e-05 9.8e-06 8.5e-04 NA 1.4e-04
22 TCGA Glioblastoma Multiforme 0.2730 0.1450 1.3e-03 0.066 0.088 0.091 NA 0.110 4.8e-03 1.2e-03 1.1e-03 NA 3.2e-04
23 TCGA Head and Neck Squamous Cell Carcinoma 0.0471 0.0293 4.3e-03 0.037 0.019 0.020 NA 0.027 4.9e-05 2.8e-03 2.1e-03 NA 4.8e-04
24 TCGA Kidney Renal Clear Cell Carcinoma 0.0991 0.0440 4.9e-06 0.054 0.050 0.038 NA 0.046 1.1e-06 2.4e-06 3.4e-05 NA 5.6e-06
25 TCGA Lung Adenocarcinoma 0.0463 0.0229 7.2e-04 0.050 0.021 0.036 NA 0.042 1.4e-06 1.6e-03 4.4e-05 NA 1.0e-05
26 TCGA Lung Squamous Cell Carcinoma 0.0310 0.0172 4.0e-03 0.029 0.026 0.024 NA 0.022 2.7e-04 5.6e-04 9.4e-04 NA 1.3e-03
27 TCGA Pancreatic Adenocarcinoma 0.2260 0.0790 3.7e-08 0.207 0.173 0.197 NA 0.173 4.2e-09 1.0e-07 1.1e-08 NA 9.5e-08
28 TCGA Prostate Adenocarcinoma 0.0747 0.0398 5.1e-04 0.041 0.032 0.033 NA 0.039 3.7e-05 2.7e-04 1.9e-04 NA 6.2e-05
29 TCGA Stomach Adenocarcinoma 0.0960 0.0420 1.9e-04 0.076 0.055 0.067 NA 0.066 3.8e-06 8.3e-05 1.4e-05 NA 1.5e-05
30 TCGA Thyroid Carcinoma 0.0720 0.0290 7.1e-07 0.023 0.058 0.063 NA 0.066 2.2e-03 2.7e-06 8.9e-07 NA 4.7e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
Bipolar Disorder (2018) 2.6 4.1 11.4 3.4 3.1 -1.8 -1.9 -0.2 -0.3 2.7 -2.0 -1.8 2.1 -0.7 -2.3 -1.1 -0.2 -1.2 2.1 -1.9 -1.5 -2.2 1.9 2.4 2.0 1.9 1.0 2.0 2.7 2.3 2.0 2.1 3.0
Bipolar Disorder or Schizophrenia 0.8 2.0 5.6 2.4 2.2 -1.3 -1.5 -0.3 -0.6 2.0 -0.9 -1.4 1.4 -0.6 -1.5 -1.3 -0.3 -0.9 1.4 -1.4 -0.7 -1.4 1.3 1.3 1.4 1.5 1.1 1.6 1.9 1.6 1.2 1.5 2.2
Depressed Affect (Nagel 2018) 0.4 0.8 3.7 -1.8 -1.9 -0.2 -0.1 0.1 -1.0 -0.2 -0.1 -0.1 -1.9 -0.8 -0.4 -0.5 -1.1 -0.6 -1.8 -0.1 -0.6 1.4 -0.2 1.1 0.1 0.1 -0.6 0.1 -0.5 -0.3 0.1 -0.1 -0.9
Depression (Nagel 2018) 0.2 0.3 1.2 -0.8 -0.7 0.4 0.5 -0.2 -0.7 -0.5 0.6 0.5 -0.4 0.2 0.2 0.4 0.1 0.3 -0.4 0.6 0.4 1.1 -0.7 0.4 -0.5 -0.5 -0.9 -0.5 -0.8 -0.6 -0.5 -0.6 -0.7
Intelligence (Savage-Jansen 2018) 0.2 0.6 2.0 0.8 1.0 0.7 0.6 1.4 0.5 -0.1 0.6 0.8 1.2 0.9 0.7 0.6 1.1 0.7 1.3 0.6 0.6 0.0 -0.7 -0.6 -0.7 -0.6 -0.8 -0.5 -0.7 -0.7 -0.6 -0.5 0.1
Neuroticism (Nagel 2018) 0.3 0.8 4.5 0.2 0.1 -1.0 -1.0 0.3 -0.0 1.0 -1.4 -1.0 -0.4 -1.0 -1.1 -1.0 -0.7 -1.0 -0.0 -1.0 -1.1 -0.2 0.8 2.1 1.0 1.0 0.2 0.9 0.5 0.8 1.0 0.8 0.8
Schizophrenia (2018) 0.1 0.1 0.6 0.3 0.2 -0.2 -0.3 -0.2 -0.4 0.4 0.5 -0.4 0.1 -0.2 -0.2 -0.8 -0.2 -0.2 0.1 -0.3 0.3 -0.2 0.2 -0.2 0.2 0.3 0.5 0.5 0.2 0.2 -0.0 0.3 0.5
Schizophrenia vs Biploar Disorder 0.6 0.8 2.5 -1.5 -1.5 0.5 0.4 -1.1 1.2 -1.0 1.2 0.5 -1.1 -0.1 0.7 -0.1 -0.3 0.3 -1.2 0.3 0.3 0.3 -0.7 -1.6 -0.6 -0.4 0.0 -0.6 -1.5 -1.1 -0.7 -0.6 -0.9
Worry (Nagel 2018) 0.5 1.0 4.0 2.0 2.0 -0.6 -0.6 0.3 1.1 1.0 -1.1 -0.6 1.5 0.1 -0.8 -0.0 0.4 -0.2 1.6 -0.6 -0.5 -1.1 0.4 1.8 0.6 0.6 -0.1 0.6 0.4 0.8 0.7 0.6 1.6
Alzheimer’s Disease (in mother) 0.5 0.5 1.9 -1.4 -1.3 0.4 0.4 -0.1 -1.1 -0.8 0.8 0.4 -1.1 -0.0 0.6 0.3 -0.2 0.3 -1.0 0.3 0.3 1.2 -0.7 -0.2 -0.4 -0.4 -0.8 -0.6 -1.0 -0.9 -0.2 -0.6 -1.2
Alzheimer’s Disease (in father) 0.6 0.6 2.2 1.1 1.3 0.5 0.4 1.5 1.3 -0.3 0.6 0.3 1.4 0.8 0.3 0.3 1.1 0.7 1.4 0.5 1.1 -0.1 -0.4 -0.3 -0.6 -0.4 -0.2 -0.4 -0.2 -0.3 -1.0 -0.3 0.5
Alzheimer’s Disease (including proxy) 0.2 0.2 0.8 -0.7 -0.7 0.3 0.3 0.4 -0.3 -0.7 0.8 0.2 -0.6 0.0 0.3 0.2 -0.1 0.3 -0.4 0.2 0.4 0.9 -0.6 -0.3 -0.3 -0.3 -0.5 -0.6 -0.9 -0.8 -0.5 -0.4 -0.6
Crohns Disease (2017) 0.2 0.4 1.4 0.6 0.7 0.5 0.6 -1.2 0.4 -0.5 0.4 0.5 1.0 0.8 0.7 0.5 0.8 0.7 0.9 0.5 -0.5 0.3 -0.6 0.1 -0.6 -0.6 -0.8 -0.6 -0.6 -0.5 -0.8 -0.6 -0.1
Irritable Bowel Disease (IBD) 0.7 1.7 3.1 -0.6 -0.3 1.4 1.4 0.4 -0.1 -1.7 1.4 1.4 0.4 1.4 1.7 0.4 1.1 1.5 0.3 1.1 0.6 1.6 -1.8 -1.4 -1.5 -1.4 -1.3 -1.7 -1.5 -1.7 -1.7 -1.6 -1.2
Ulcerative Colitis (UC) 2.1 3.9 6.6 -1.4 -0.9 2.3 2.2 2.3 0.1 -2.6 2.0 2.2 0.1 1.8 2.1 0.7 1.5 2.1 0.0 1.9 1.6 2.3 -2.5 -2.4 -2.3 -2.2 -1.6 -2.5 -2.2 -2.5 -2.5 -2.4 -2.0
Major Depression (MDD) 0.4 0.5 3.4 1.2 1.3 0.4 0.3 1.8 0.1 0.1 -0.1 0.3 1.4 0.7 -0.5 0.9 1.0 0.7 1.4 0.0 0.9 0.3 -0.3 0.8 -0.2 -0.3 -0.7 -0.3 0.1 -0.2 -0.2 -0.2 0.0
Reaction Time 0.1 0.1 0.9 0.5 0.6 0.0 0.0 0.3 1.0 -0.1 -0.1 0.1 0.7 0.3 0.1 0.7 0.3 0.2 0.6 -0.0 0.4 -0.1 -0.1 -0.4 -0.1 -0.0 -0.0 -0.1 0.1 0.1 -0.3 -0.1 0.1
Verbal and Numeric Reasoning (VNR) 0.1 0.3 1.1 0.7 0.9 0.4 0.3 1.0 0.5 -0.1 0.5 0.4 1.1 0.7 0.5 0.7 0.8 0.6 1.1 0.3 0.4 -0.2 -0.5 -0.3 -0.4 -0.3 -0.4 -0.5 -0.7 -0.6 -0.4 -0.3 0.2
Breast Cancer 0.1 0.1 1.2 -0.4 -0.5 -0.2 -0.2 0.2 0.8 -0.0 -0.4 -0.0 -0.5 -0.3 -0.1 -0.3 -0.5 -0.2 -0.6 -0.2 -0.1 -1.1 0.2 -0.6 0.2 0.2 0.3 0.1 -0.1 0.1 0.5 0.1 -0.1
Ovarian Cancer 0.7 0.9 3.6 -0.3 -0.5 -1.0 -0.9 -1.2 0.4 0.6 -1.1 -1.0 -0.9 -1.1 -0.8 -0.8 -1.1 -0.9 -0.8 -1.1 -1.9 -0.9 0.9 0.2 1.0 0.9 0.8 0.9 1.0 1.0 1.2 0.8 0.4
Prostate Cancer 0.3 0.4 1.5 -0.8 -0.7 0.5 0.7 -0.3 -0.8 -0.5 0.1 0.6 -0.2 0.5 1.0 0.8 0.3 0.4 -0.3 0.3 -0.3 1.2 -0.5 0.7 -0.5 -0.7 -1.2 -0.5 -0.4 -0.4 -0.1 -0.6 -1.1
Age at First Birth 0.1 0.2 0.8 0.9 0.9 0.1 0.0 0.1 0.5 0.1 -0.6 -0.0 0.9 0.3 0.2 0.3 0.4 -0.0 0.7 0.1 0.1 -0.7 0.3 -0.0 0.1 -0.0 0.5 0.3 0.8 0.5 0.2 0.2 0.5
Bipolar Disorder (2011) 1.6 1.6 5.1 2.2 2.2 -1.0 -1.0 1.2 -0.1 1.6 -2.0 -1.2 1.7 -0.2 -1.6 -0.6 0.2 -0.4 1.6 0.0 -0.6 -1.3 1.0 1.6 0.0 1.0 0.0 1.0 1.9 1.5 1.6 1.0 0.0
Body Mass Index (BMI) (2010) 2.2 2.9 5.2 -0.4 0.1 2.0 2.0 0.9 1.6 -1.8 2.0 2.0 0.9 1.9 2.3 1.6 1.9 1.9 1.0 1.9 1.7 1.1 -2.1 -1.5 -1.9 -2.0 -1.9 -1.9 -2.0 -1.9 -1.7 -2.0 -1.5
Coronary Artery Disease (CAD) 0.5 0.5 2.8 1.6 1.7 0.2 0.2 0.6 1.1 0.1 0.7 0.4 1.6 0.8 0.4 0.3 0.9 0.4 1.4 0.0 0.9 -0.5 -0.3 0.4 -0.3 -0.2 -0.7 -0.1 -0.4 -0.2 -0.3 -0.1 0.0
Crohns Disease (2012) 0.1 0.2 1.0 -0.1 -0.0 0.5 0.5 -0.6 -0.2 -0.5 0.2 0.5 0.2 0.5 0.4 0.7 0.5 0.5 0.2 0.5 -0.2 0.7 -0.4 0.3 -0.5 -0.5 -1.0 -0.5 -0.4 -0.4 -0.3 -0.5 -0.4
Mean Putamen Volume 0.4 0.5 4.2 0.4 0.5 0.2 0.3 1.8 2.1 -0.3 0.4 0.3 0.5 0.4 0.2 -0.1 0.6 0.5 0.7 0.3 0.7 -0.7 -0.2 -1.3 -0.3 -0.3 0.5 -0.4 0.0 -0.2 -0.6 -0.2 0.2
Fasting Glucose 0.2 0.2 1.2 0.4 0.4 -0.4 -0.4 -1.1 1.0 0.4 -0.1 -0.3 0.1 -0.4 -0.5 -0.4 0.1 -0.4 0.7 -0.5 -0.1 -0.4 0.5 0.5 0.4 0.4 0.7 0.4 0.0 0.4 -0.1 0.5 0.5
HbA1C 1.0 1.1 5.8 2.4 2.3 -0.4 -0.6 1.6 1.9 0.5 -0.4 -0.3 2.1 0.4 -1.1 0.4 0.2 0.5 1.0 -0.6 1.6 -0.7 -0.4 -0.1 0.6 0.6 0.3 -0.1 0.7 0.1 0.3 0.2 1.7
HDL Cholesterol 0.0 0.0 0.3 -0.0 -0.0 0.2 0.2 0.6 0.0 -0.0 -0.1 0.1 0.0 0.1 0.3 0.0 0.1 -0.0 -0.0 0.0 0.5 0.3 0.1 0.2 -0.2 -0.2 -0.2 0.0 -0.0 0.1 -0.1 -0.0 0.0
LDL Cholesterol 0.7 1.1 2.3 -1.0 -0.7 1.1 1.0 1.1 -0.3 -1.1 1.0 1.1 -0.1 0.8 1.2 1.5 0.7 1.0 -0.1 1.1 1.4 1.1 -1.0 -1.3 -1.0 -1.0 -0.3 -1.4 -1.3 -1.3 -1.5 -1.0 0.0
Lupus 0.2 0.3 1.8 0.9 0.9 -0.5 -0.4 1.3 0.2 0.6 -0.3 -0.2 0.6 -0.0 -0.9 -0.8 0.1 -0.1 0.6 -0.4 0.4 -0.7 0.3 0.5 0.4 0.4 -0.1 0.5 0.4 0.3 0.3 0.5 0.5
Neuroticism (2016) 0.6 0.9 1.8 -0.7 -0.4 1.2 1.2 0.8 0.8 -0.9 1.0 1.3 0.4 1.1 1.1 1.4 1.0 1.1 0.4 1.4 0.3 0.9 -0.9 -0.5 -1.2 -1.2 -1.3 -0.9 -0.9 -0.8 -1.0 -1.1 0.0
Primary Biliary Cirrhosis 0.4 0.6 1.4 1.2 1.1 -0.6 -0.7 -0.8 -0.8 0.9 -0.5 -0.7 0.6 -0.2 -1.1 -0.9 -0.1 -0.5 0.7 0.0 -0.7 -0.1 0.7 0.9 0.6 0.7 -0.2 0.7 1.2 0.9 0.6 0.7 0.8
Rheumatoid Arthritis 0.4 0.5 1.9 -0.9 -0.8 0.8 0.7 -0.1 -0.6 -0.6 0.4 0.7 -0.4 0.5 0.3 0.4 0.3 0.8 -0.4 0.8 0.2 1.4 -0.8 -0.3 -0.7 -0.7 -0.8 -0.8 -0.8 -0.9 -0.8 -0.9 -1.0
Schizophrenia (2014) 0.1 0.1 1.0 -0.3 -0.3 0.1 -0.0 -1.0 -0.7 -0.1 0.9 -0.0 -0.2 -0.1 -0.1 -0.3 -0.2 0.0 -0.3 0.0 0.1 0.4 -0.3 -0.5 -0.1 0.0 0.1 0.0 -0.3 -0.3 -0.3 -0.1 -0.2
Triglycerides 0.1 0.2 0.5 -0.0 0.1 0.3 0.3 -0.5 0.3 -0.4 0.7 0.3 0.4 0.4 0.5 0.2 0.4 0.4 0.3 0.4 0.3 -0.1 -0.3 -0.7 -0.3 -0.3 0.1 -0.6 -0.6 -0.6 -0.6 -0.3 0.0
Type 2 Diabetes (T2D) (2012) 2.8 3.2 12.5 2.6 3.0 1.0 1.0 1.5 1.6 -1.0 1.5 1.0 3.5 2.2 1.5 1.9 2.5 2.2 3.3 1.0 2.2 0.8 -1.6 0.3 -1.2 -1.0 -1.9 -1.6 -0.8 -1.3 -1.7 -1.1 0.0
Ulcerative Colitis 1.1 1.6 3.0 -0.6 -0.4 1.5 1.4 1.3 0.0 -1.6 1.4 1.4 0.2 1.3 1.5 0.6 1.0 1.4 0.1 1.2 1.6 1.6 -1.7 -1.7 0.0 -1.4 -0.7 -1.6 -1.2 -1.6 -1.7 -1.6 -1.1
Blood Eosinophil Count 0.4 3.3 24.5 0.1 0.5 2.2 1.9 5.0 0.1 -1.6 0.6 1.6 1.2 1.9 1.2 0.8 2.0 1.8 1.3 2.0 3.4 1.4 -1.5 -2.2 -1.9 -1.9 -1.2 -1.8 -0.6 -1.2 -1.8 -1.8 -0.9
Blood Platelet Count 0.1 1.5 3.6 1.4 1.2 -1.4 -1.3 1.7 0.7 1.5 -1.1 -1.2 0.6 -0.8 -0.8 -1.5 -0.6 -1.0 0.6 -1.1 -0.7 -1.9 1.4 0.7 1.2 1.3 1.3 1.2 1.4 1.4 0.7 1.4 1.5
Blood Red Count 0.1 0.5 1.5 -1.2 -1.1 0.6 0.5 0.8 -1.2 -0.7 0.7 0.4 -0.8 0.1 0.3 -0.0 -0.1 0.3 -0.8 0.5 0.7 1.2 -0.7 -0.8 -0.5 -0.5 -0.6 -0.7 -0.8 -0.8 -0.5 -0.6 -1.0
Blood White Count 0.2 1.7 3.6 -0.2 -0.5 -1.5 -1.5 0.2 0.1 1.2 -1.7 -1.4 -1.1 -1.6 -1.6 -1.9 -1.6 -1.5 -1.1 -1.4 -0.5 -1.8 1.4 0.2 1.4 1.5 1.7 1.3 1.2 1.2 1.4 1.4 1.0
Heel T-Score 0.4 3.4 27.9 -1.5 -1.1 2.0 1.8 5.3 1.6 -2.0 1.2 1.6 -0.2 1.3 1.0 0.9 1.2 1.7 -0.1 1.7 1.7 1.6 -1.8 -2.3 -2.0 -1.8 -0.7 -1.9 -1.6 -1.8 -2.4 -1.9 -1.5
BMI 1.7 9.7 15.8 -1.1 -0.3 3.8 3.6 4.0 2.1 -3.2 3.3 3.6 1.3 3.4 2.4 2.4 3.2 3.6 1.4 3.6 4.0 2.5 -3.6 -3.2 -3.5 -3.6 -3.3 -3.6 -2.9 -3.4 -3.0 -3.6 -2.9
Height 4.2 80.9 127.9 7.4 5.5 -10.2 -9.9 -9.1 -2.2 11.3 -10.6 -10.1 0.6 -7.5 -9.2 -6.9 -6.5 -8.9 0.6 -9.6 -10.1 -9.7 10.3 9.7 10.1 9.9 7.7 10.2 11.1 11.0 10.2 10.2 9.9
Waist Hip Ratio (WHR) 1.5 7.0 13.5 -1.9 -1.3 3.1 3.0 -1.1 0.2 -2.9 3.4 3.3 0.2 2.6 3.7 3.2 2.2 2.5 0.2 3.1 1.3 2.6 -2.8 -3.0 -3.1 -3.0 -2.2 -2.7 -2.9 -3.1 -3.0 -2.9 -3.1
Systolic Blood Pressure 0.0 0.1 1.2 -0.5 -0.5 0.0 0.1 -0.0 -1.1 -0.5 -0.2 -0.0 -0.4 -0.1 0.1 0.2 -0.2 -0.0 -0.4 0.2 -0.8 0.4 -0.0 0.3 -0.1 -0.1 0.2 -0.2 -0.2 -0.1 -0.3 -0.1 -0.2
Smoking Status 0.1 0.3 1.3 0.8 0.8 -0.0 -0.2 0.5 0.9 0.6 -0.8 -0.0 0.7 0.2 -0.6 -0.4 0.3 0.0 0.7 -0.2 -0.2 -1.2 0.3 0.0 0.2 0.2 0.7 0.3 0.4 0.4 0.3 0.3 0.9
Allergy or Eczema 0.3 0.9 2.0 -1.0 -0.8 1.0 1.1 -1.1 -0.7 -1.4 1.0 1.0 -0.2 0.8 0.7 0.1 0.6 1.0 -0.2 0.9 0.9 1.1 -1.1 -0.9 -1.0 -1.1 -1.4 -1.1 -0.6 -1.0 -0.3 -1.2 -1.4
Cardiovascular Disease 0.1 0.3 0.9 0.4 0.3 -0.6 -0.7 0.1 -0.2 0.4 -0.3 -0.6 -0.1 -0.7 -0.8 -1.0 -0.5 -0.5 -0.0 -0.7 0.7 -0.1 0.6 0.5 0.6 0.7 0.4 0.7 0.8 0.7 0.5 0.7 0.7
Hypothyroidism (self reported) 0.2 0.4 1.3 0.5 0.4 -0.4 -0.5 1.1 0.0 0.9 -0.9 -0.6 0.1 -0.2 -1.1 -1.1 -0.3 -0.3 0.1 -0.5 0.3 -0.3 0.5 0.9 0.6 0.5 0.1 0.5 0.9 0.8 0.9 0.5 0.6
Respiratory disease 0.4 0.8 3.0 -0.3 -0.5 -0.9 -0.8 -0.3 -0.4 0.6 -1.7 -0.8 -0.8 -0.9 -1.3 -1.1 -1.0 -0.8 -0.9 -0.7 -1.5 -0.3 0.9 1.3 0.9 0.8 -0.1 0.7 0.9 1.0 1.3 0.7 0.2
Type 2 Diabetes (T2D) (2018) 5.2 9.8 14.6 -0.1 0.7 3.6 3.6 1.4 2.7 -3.3 3.3 3.7 2.4 3.8 3.6 3.5 3.7 3.7 2.4 3.5 3.2 1.5 -3.4 -3.5 -3.6 -3.6 -2.6 -3.5 -2.8 -3.2 -3.8 -3.4 -2.4
Lung FEV1/FVC ratio 0.3 1.6 5.8 -1.3 -1.1 1.4 1.3 0.6 0.8 -1.4 2.4 1.3 -0.5 0.9 1.6 1.5 0.6 0.9 -0.5 1.4 0.5 0.6 -1.4 -2.1 -1.3 -1.3 -0.7 -1.2 -1.7 -1.7 -0.8 -1.3 -1.5
Lung FVC 0.9 4.3 9.8 -1.8 -2.3 -2.0 -1.8 -1.6 -2.3 1.6 -3.1 -2.0 -3.1 -2.7 -2.0 -1.8 -2.8 -2.4 -2.9 -1.8 -2.9 0.0 2.0 2.6 1.7 1.8 0.9 1.8 1.2 1.7 1.8 1.7 0.3
Neuroticism 0.3 0.7 4.3 1.4 1.6 0.4 0.4 1.2 2.1 0.1 0.2 0.5 1.6 0.9 0.4 0.8 1.1 0.7 1.6 0.5 0.1 -0.5 -0.4 0.6 -0.4 -0.4 -0.8 -0.4 -0.2 -0.2 -0.3 -0.3 0.6
Chronotype (morning person) 1.8 4.1 8.0 2.0 1.6 -2.4 -2.3 -0.9 0.0 2.6 -2.6 -2.3 0.3 -1.7 -2.0 -1.4 -1.4 -1.8 0.4 -2.1 -1.7 -1.7 2.4 2.5 2.3 2.3 1.8 2.2 2.8 2.6 2.0 2.3 2.4
Hair Pigment 0.3 8.8 17.1 -1.3 -0.6 3.1 3.2 2.5 1.6 -3.2 3.9 3.3 1.1 3.1 4.1 3.1 2.8 3.2 1.1 3.2 1.4 2.9 -3.5 -2.7 -3.3 -3.2 -3.0 -3.4 -3.4 -3.7 -3.6 -3.3 -3.0
Tanning 0.4 5.2 8.9 -0.5 -1.1 -2.5 -2.6 -1.4 -1.4 2.2 -2.9 -2.7 -2.0 -2.9 -3.0 -2.5 -2.9 -2.6 -2.2 -2.5 -1.4 -1.1 2.5 2.0 2.4 2.6 2.4 2.5 2.0 2.4 2.1 2.4 1.7
Hand grip strength (left) 0.4 1.1 4.3 -0.3 -0.5 -1.1 -0.9 -1.6 -2.1 0.8 -1.4 -1.0 -0.9 -1.0 -0.4 -0.3 -1.1 -0.9 -0.9 -0.8 -1.7 0.1 0.9 2.0 1.0 0.9 -0.1 0.8 0.9 1.0 1.3 0.8 0.3
Number of treatments/medications taken 0.2 0.4 2.3 1.2 1.3 -0.1 -0.2 -0.2 1.5 0.3 -0.7 -0.1 1.1 0.3 -0.3 0.3 0.5 0.2 1.1 -0.1 -0.0 -0.9 0.2 0.1 0.3 0.2 0.2 0.2 0.6 0.6 0.6 0.2 0.8
Average weekly spirits intake 0.1 0.1 0.5 0.5 0.6 0.2 0.1 -0.1 0.1 0.3 0.3 0.0 0.7 0.3 -0.3 0.1 0.4 0.2 0.6 0.2 -0.2 -0.6 -0.0 -0.5 -0.1 -0.1 0.3 -0.0 -0.2 -0.0 -0.3 0.0 0.4
Sensitivity / hurt feelings 0.4 0.7 4.7 0.8 1.0 0.7 0.6 2.2 0.6 -0.2 -0.6 0.5 1.3 0.9 0.4 0.9 1.1 1.0 1.3 0.4 0.5 0.4 -0.7 0.6 -0.5 -0.6 -0.7 -0.8 -0.4 -0.4 -0.6 -0.7 0.5
Frequency of depressed mood in last 2 weeks 1.6 2.2 6.9 -2.2 -2.0 1.3 1.4 -0.3 -2.4 -1.5 1.5 1.3 -1.2 0.7 1.0 0.3 0.3 0.8 -1.3 1.3 0.2 2.6 -1.4 0.2 -1.4 -1.4 -2.1 -1.4 -1.9 -1.6 -1.3 -1.5 -2.2
Hearing difficulty/problems: Yes 1.8 2.7 4.9 0.5 0.9 1.8 1.7 1.2 0.3 -1.6 1.6 1.7 1.6 2.0 1.8 1.7 2.1 1.9 1.7 1.8 2.2 1.7 -1.8 -1.1 -1.8 -1.7 -2.0 -1.8 -1.2 -1.6 -1.8 -1.7 -1.0
Relative age of first facial hair 1.4 2.8 7.1 2.7 2.4 -1.4 -1.6 0.9 0.8 1.9 -2.0 -1.5 1.5 -0.7 -1.3 -1.3 -0.3 -1.1 1.5 -1.7 0.1 -2.4 1.7 0.8 1.7 1.6 2.1 1.5 2.5 2.0 1.5 1.7 2.5
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 2.7 1.2 1.2 -0.3 -0.3 0.3 1.6 0.6 -0.2 -0.2 1.0 0.2 -0.3 -0.8 0.3 0.0 1.0 -0.2 0.1 -0.9 0.3 0.1 0.4 0.3 0.1 0.3 0.5 0.4 0.5 0.4 0.6
Ever used hormone-replacement therapy (HRT) 1.2 1.5 5.8 0.6 1.0 1.4 1.3 0.5 0.6 -0.9 0.6 1.1 1.7 1.6 1.2 2.4 1.7 1.5 1.6 1.5 0.9 1.1 -1.2 -0.4 -1.3 -1.3 -1.3 -1.3 -0.8 -0.9 -1.4 -1.2 -0.4
Ever had hysterectomy (womb removed) 0.4 0.5 2.0 0.0 -0.1 -0.6 -0.7 -0.8 0.3 0.8 -0.8 -0.8 -0.5 -0.7 -0.6 -1.2 -0.7 -0.8 -0.4 -0.7 -0.1 -0.7 0.7 0.0 0.8 0.7 1.4 0.7 0.5 0.6 0.7 0.7 0.7
Systolic blood pressure, automated reading 0.5 1.4 2.6 0.1 0.5 1.4 1.3 1.0 0.9 -1.3 0.8 1.3 1.1 1.5 1.2 1.2 1.5 1.5 1.1 1.4 0.4 0.8 -1.4 -1.0 -1.3 -1.3 -0.7 -1.4 -1.1 -1.2 -1.6 -1.4 -0.6
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 6.6 -0.0 0.2 1.0 0.9 1.5 2.6 -0.9 0.7 1.0 0.6 1.0 0.5 0.5 1.0 1.2 0.6 0.8 1.7 -0.5 -1.0 -1.8 -1.1 -0.9 -0.0 -1.0 -0.9 -0.9 -1.2 -1.0 -0.4
Angina 1.2 1.6 2.8 -0.2 0.2 1.6 1.6 0.6 1.2 -1.4 0.8 1.5 0.9 1.6 1.0 1.1 1.5 1.7 0.8 1.6 1.1 0.7 -1.5 -1.4 -1.6 -1.6 -1.2 -1.6 -1.2 -1.2 -1.5 -1.6 -1.0
Medication for hormone replacement therapy 2.6 2.9 5.7 -0.9 -0.5 1.9 2.0 -0.9 -0.6 -1.9 0.9 2.0 0.5 1.9 1.6 2.4 1.6 2.0 0.4 2.1 0.8 2.3 -2.0 -0.8 -2.0 -2.0 -2.1 -2.2 -1.5 -1.8 -2.1 -2.1 -1.8
Vitamin and mineral supplements 4.7 6.4 10.0 1.2 0.5 -2.8 -2.9 -1.3 -0.9 3.0 -2.5 -2.8 -0.9 -2.7 -3.2 -3.0 -2.5 -2.9 -0.9 -2.9 -2.5 -2.6 3.0 2.2 2.8 2.9 2.3 3.0 2.7 2.8 3.0 3.0 2.5
Supplements: Zinc 1.6 1.8 5.0 -0.8 -0.6 1.4 1.4 0.5 1.9 -1.6 2.0 1.5 0.1 1.3 1.2 1.2 1.0 1.3 0.1 1.5 1.4 0.4 -1.3 -2.2 -1.6 -1.4 -0.7 -1.3 -1.6 -1.5 -1.7 -1.3 -1.5
Medication: Co-codamol 1.2 1.3 3.0 -1.0 -0.7 1.3 1.3 0.2 0.6 -1.3 1.6 1.4 0.0 1.1 1.4 1.0 0.9 1.1 0.0 1.3 0.6 0.7 -1.4 -1.2 -1.3 -1.3 -1.1 -1.3 -1.7 -1.5 -1.2 -1.3 -1.3
Medication: Metformin 2.6 3.7 6.9 -0.3 0.2 2.2 2.2 1.3 1.7 -2.1 1.8 2.4 1.2 2.2 2.4 2.1 2.2 2.2 1.2 2.1 1.7 0.5 -2.1 -2.6 -2.2 -2.2 -1.3 -2.2 -1.9 -2.1 -2.2 -2.1 -1.5
Diabetes (father) 2.4 3.0 4.8 0.1 0.6 2.0 2.0 0.1 0.8 -1.7 1.9 2.0 1.5 2.2 1.8 1.4 2.2 2.2 1.5 1.9 1.5 1.5 -2.1 -1.9 -2.0 -2.0 -1.5 -2.0 -1.4 -1.9 -2.1 -2.0 -1.4
Diabetes (mother) 1.2 1.6 5.2 0.9 1.2 1.1 1.0 2.3 2.1 -0.9 1.0 1.0 1.7 1.4 1.3 1.4 1.5 1.3 1.6 1.0 2.2 0.1 -1.0 -1.4 -0.9 -1.0 -0.4 -1.1 -0.6 -0.9 -1.0 -0.9 -0.0
Severe depression (siblings) 0.3 0.3 1.1 0.2 0.4 0.6 0.6 0.5 -0.6 -0.4 0.2 0.4 0.6 0.7 0.4 1.1 0.7 0.7 0.6 0.7 0.1 0.8 -0.6 0.4 -0.6 -0.6 -1.0 -0.6 -0.5 -0.4 -0.5 -0.6 -0.3
Pack years adult smoking proportion 0.8 1.2 6.5 -2.5 -2.5 0.6 0.5 -0.3 -1.5 -0.8 0.1 0.5 -2.2 -0.5 0.2 -0.9 -0.9 -0.1 -2.2 0.3 0.2 1.3 -0.6 -0.5 -0.6 -0.5 -0.4 -0.6 -1.2 -0.9 -0.5 -0.7 -1.4
Impedance of leg (right) 0.1 0.5 2.3 1.5 1.5 -0.4 -0.4 1.4 1.0 0.3 0.0 -0.4 1.2 0.2 0.5 -0.0 0.3 -0.1 1.1 -0.4 0.5 -0.6 0.3 0.4 0.5 0.4 0.8 0.4 0.4 0.4 -0.1 0.5 1.1
Leg fat-free mass (left) 0.6 3.3 7.2 1.3 0.9 -1.8 -1.8 -2.7 -1.1 2.4 -2.3 -1.9 -0.0 -1.4 -2.4 -1.3 -1.2 -1.6 -0.0 -1.7 -2.3 -1.7 2.0 2.2 1.8 1.8 0.8 1.9 2.5 2.3 2.3 1.9 1.7
Trunk fat percentage 0.6 2.3 14.2 1.2 1.6 1.4 1.3 3.8 2.8 -0.7 0.7 1.3 1.9 1.7 0.7 0.5 1.9 1.6 2.0 1.3 2.1 -0.5 -1.1 -1.5 -1.2 -1.3 -0.5 -1.1 -0.4 -0.8 -0.9 -1.2 -0.0
Hand grip strength (right) 0.5 1.3 4.9 -0.9 -1.2 -1.0 -0.8 -1.9 -2.2 0.7 -1.1 -0.9 -1.6 -1.3 -0.3 0.0 -1.4 -1.1 -1.6 -0.8 -1.9 0.2 0.9 1.8 0.9 0.8 0.3 0.9 0.7 0.8 1.0 0.7 -0.1
Townsend deprivation index at recruitment 0.2 0.3 1.1 0.5 0.3 -0.4 -0.5 0.8 -1.0 0.6 -0.2 -0.5 0.0 -0.4 -0.7 -0.8 -0.3 -0.6 0.1 -0.4 0.2 -0.1 0.5 1.1 0.6 0.5 -0.3 0.6 0.5 0.4 1.0 0.6 0.4
Current tobacco smoking 0.2 0.4 1.1 0.2 0.1 -0.5 -0.6 -0.0 0.2 0.8 -1.0 -0.6 -0.2 -0.6 -1.0 -0.9 -0.5 -0.6 -0.2 -0.7 -0.0 -0.9 0.6 0.2 0.7 0.6 0.8 0.6 0.5 0.6 0.8 0.6 0.7
Average weekly fortified wine intake 1.3 1.5 5.5 1.7 2.0 1.0 0.9 1.5 1.3 -0.5 0.6 1.0 2.3 1.6 0.9 1.5 1.9 1.4 2.3 1.0 0.7 -0.1 -0.9 -0.7 -1.0 -0.9 -0.7 -1.0 -0.4 -0.6 -1.2 -0.8 0.4
Maternal smoking around birth 1.2 1.7 6.5 2.0 2.3 1.0 0.9 1.5 2.5 -0.5 0.8 1.0 2.5 1.7 0.6 1.0 2.0 1.3 2.5 1.0 0.4 -0.5 -0.8 -1.0 -1.0 -0.9 -0.9 -0.8 -0.1 -0.4 -1.0 -0.7 0.5
Fed-up feelings 0.6 1.1 5.1 -2.0 -2.2 -0.4 -0.3 0.3 -1.6 -0.0 -0.1 -0.4 -2.2 -1.1 -0.7 -1.2 -1.5 -0.9 -2.3 -0.4 -0.6 1.3 0.3 0.9 0.3 0.3 0.0 0.3 -0.3 -0.0 0.2 0.2 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.7 -0.6 -0.5 0.3 0.3 -0.0 -0.7 -0.3 0.2 0.3 -0.3 0.1 -0.3 -0.0 0.0 0.1 -0.3 0.3 0.7 0.8 -0.4 0.5 -0.3 -0.3 -0.8 -0.4 -0.5 -0.4 -0.1 -0.4 -0.4
Relative age voice broke 2.0 3.1 11.0 3.3 3.3 -0.9 -1.1 2.5 1.8 1.4 -2.3 -1.1 2.5 0.0 -1.2 -0.6 0.6 -0.4 2.5 -1.2 0.3 -2.2 1.3 1.2 1.4 1.1 1.6 1.1 2.3 1.9 1.4 1.3 2.9
Taking other prescription medications 0.3 0.4 1.3 1.1 1.1 -0.3 -0.4 -0.5 0.4 0.8 -1.0 -0.4 0.7 -0.0 -0.8 -0.7 0.2 -0.2 0.8 -0.4 -0.6 -0.7 0.6 0.3 0.5 0.4 0.3 0.5 1.0 0.9 0.8 0.4 0.9
Age when periods started (menarche) 3.9 9.3 20.9 4.6 4.1 -3.0 -3.1 0.5 0.2 3.6 -3.9 -3.1 2.4 -1.6 -3.0 -1.9 -0.8 -2.0 2.4 -3.1 -1.0 -3.1 3.2 3.5 3.2 3.1 2.3 3.1 4.5 3.8 3.2 3.2 4.5
Bilateral oophorectomy (both ovaries removed) 3.3 3.9 8.9 -2.7 -2.3 2.2 2.2 0.1 -0.5 -2.2 1.9 2.2 -1.3 1.3 2.0 1.6 0.9 1.5 -1.2 2.2 0.3 2.3 -2.1 -2.0 -2.2 -2.2 -1.8 -2.1 -2.4 -2.3 -1.9 -2.3 -3.0
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 3.9 -1.1 -0.9 1.0 1.0 2.0 0.7 -1.2 1.5 1.0 -0.5 0.6 0.9 0.3 0.5 0.9 -0.4 0.9 1.3 1.1 -1.2 -1.3 -1.2 -1.0 -1.0 -1.1 -1.3 -1.3 -1.2 -1.1 -1.3
Tinnitus: Yes, but not now, but have in the past 3.4 3.7 6.8 0.8 0.4 -2.1 -2.1 -0.5 -0.5 2.2 -2.1 -2.2 -0.8 -2.0 -2.6 -2.5 -1.8 -2.2 -0.6 -2.2 -1.7 -1.7 2.3 1.5 2.0 2.1 2.2 2.3 2.2 2.4 1.7 2.2 1.8
Qualifications: CSEs or equivalent 0.8 1.1 5.6 -2.3 -2.4 0.1 0.2 0.1 -1.8 -0.9 0.3 -0.1 -2.2 -0.7 0.1 -0.6 -1.0 -0.3 -2.2 0.2 -0.8 1.7 -0.4 0.2 -0.1 -0.2 -0.3 -0.4 -0.7 -0.6 -0.1 -0.5 -1.3
Serious illness, injury or assault to yourself 0.2 0.2 1.3 -0.5 -0.5 0.2 0.3 -0.9 1.1 -0.3 -0.0 0.4 -0.4 0.1 0.2 -0.5 0.0 0.2 -0.4 0.6 -0.6 -0.7 -0.2 -1.2 -0.3 -0.3 0.5 -0.2 -0.2 -0.1 -0.2 -0.3 -0.5
High blood pressure 0.1 0.3 1.1 1.1 1.1 -0.2 -0.3 0.7 0.9 0.3 -0.2 -0.2 0.7 -0.0 -0.4 -0.7 0.2 0.0 0.8 -0.3 0.5 -0.5 0.3 0.2 0.3 0.3 0.2 0.3 0.4 0.4 0.3 0.4 0.8
Hayfever, allergic rhinitis or eczema 0.7 1.6 4.0 -0.5 -0.1 1.4 1.5 -0.4 -0.4 -1.6 1.6 1.4 0.6 1.4 1.3 1.1 1.3 1.5 0.6 1.5 1.1 1.3 -1.5 -0.9 -1.4 -1.5 -2.0 -1.6 -1.0 -1.4 -0.8 -1.5 -1.4
Multivitamins +/- minerals 4.4 5.6 8.9 -0.6 0.1 2.6 2.7 1.6 1.6 -2.7 2.0 2.6 1.3 2.7 2.8 2.9 2.6 2.8 1.3 2.8 3.0 2.1 -2.7 -1.6 -2.6 -2.7 -2.3 -2.8 -2.5 -2.5 -2.7 -2.7 -2.0
Stomach or abdominal pain in last month 0.4 0.5 2.6 -0.9 -1.1 -0.3 -0.4 -1.6 -0.3 0.3 -0.8 -0.5 -1.3 -0.8 -0.4 0.0 -0.9 -0.6 -1.2 -0.2 -0.7 -0.4 0.5 0.0 0.4 0.4 0.8 0.4 0.2 0.4 0.6 0.3 -0.0
Supplements: Glucosamine 0.6 0.8 4.2 -0.6 -0.4 0.9 0.9 0.5 1.1 -0.9 1.0 0.9 0.0 0.7 1.2 -0.0 0.7 0.9 0.1 0.9 1.4 0.3 -0.9 -2.0 -0.8 -0.9 0.3 -0.9 -0.8 -0.9 -1.0 -0.9 -0.8
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 1.0 0.4 0.3 -0.3 -0.2 0.1 1.0 0.3 0.2 -0.2 0.3 -0.1 -0.3 -0.4 -0.0 -0.2 0.3 -0.2 0.9 -0.6 0.2 -0.3 0.3 0.2 0.3 0.3 0.3 0.2 0.4 0.3 0.2
Medication: Atenolol 0.4 0.6 2.5 1.2 1.1 -0.2 -0.3 -1.2 1.6 0.7 -0.4 -0.3 0.7 -0.0 -0.6 0.3 0.2 -0.1 0.8 -0.2 -1.1 -1.6 0.4 -0.8 0.2 0.3 1.0 0.4 0.4 0.5 0.2 0.4 1.0
Medication: Levothyroxine sodium 0.6 1.0 3.5 0.3 0.1 -0.9 -0.9 1.2 -0.1 1.0 -1.9 -1.1 -0.4 -0.8 -1.5 -1.3 -0.8 -0.9 -0.4 -0.9 -0.0 -0.7 1.1 1.2 1.1 0.9 0.9 0.9 1.4 1.4 1.4 0.9 0.9
Sitting height 1.9 13.6 23.7 2.9 2.2 -4.2 -3.9 -4.9 -1.6 4.6 -4.3 -4.0 0.2 -2.9 -3.8 -2.5 -2.5 -3.5 0.2 -3.7 -4.8 -3.6 4.3 4.3 3.9 3.9 2.7 4.1 4.7 4.6 4.0 4.1 3.7
Chronic bronchitis/emphysema (father) 1.4 1.7 3.4 -0.8 -0.5 1.3 1.4 0.0 0.9 -1.6 1.6 1.6 0.1 1.2 1.3 1.0 1.1 1.3 0.3 1.3 0.8 1.3 -1.6 -0.9 -1.4 -1.4 -1.8 -1.6 -1.8 -1.7 -1.1 -1.5 -1.6
High blood pressure (mother) 0.1 0.2 1.1 0.3 0.3 -0.3 -0.3 0.5 -0.6 0.4 -0.5 -0.4 0.0 -0.3 -0.2 0.2 -0.2 -0.3 0.1 -0.3 -1.1 0.5 0.2 1.0 0.3 0.3 0.2 0.3 0.2 0.2 -0.1 0.3 0.4
Body mass index (BMI) 2.2 9.5 14.7 -1.4 -0.6 3.8 3.7 3.8 2.1 -3.3 2.9 3.7 1.1 3.3 2.5 2.5 3.1 3.6 1.1 3.7 3.3 2.3 -3.6 -3.2 -3.6 -3.7 -3.0 -3.6 -3.0 -3.4 -3.1 -3.7 -3.0
Impedance of leg (left) 0.1 0.6 2.5 1.6 1.5 -0.5 -0.6 1.4 1.0 0.5 -0.1 -0.6 1.2 0.0 0.2 -0.4 0.2 -0.2 1.1 -0.6 0.6 -0.8 0.5 0.3 0.6 0.6 1.0 0.6 0.6 0.6 0.1 0.6 1.3
Leg predicted mass (left) 0.7 3.6 7.1 1.3 0.9 -1.9 -1.8 -2.7 -1.1 2.5 -2.4 -1.9 -0.0 -1.5 -2.5 -1.4 -1.3 -1.7 -0.0 -1.8 -2.3 -1.8 2.1 2.3 1.9 1.8 0.9 2.0 2.6 2.4 2.4 1.9 1.8
Trunk fat mass 0.2 0.9 5.2 1.6 1.7 0.5 0.4 2.3 2.1 0.3 -0.2 0.4 1.7 0.9 -0.2 -0.0 1.2 0.8 1.7 0.4 1.0 -1.1 -0.2 -0.5 -0.3 -0.4 -0.1 -0.2 0.6 0.2 0.1 -0.2 0.6
Waist circumference 1.3 4.6 7.6 0.1 0.7 2.6 2.5 2.8 2.1 -2.0 2.0 2.5 1.7 2.7 1.8 1.7 2.7 2.6 1.8 2.5 2.6 1.0 -2.3 -2.2 -2.5 -2.5 -2.0 -2.3 -1.7 -2.0 -2.1 -2.4 -1.5
Number of incorrect matches in round 0.0 0.1 0.6 0.1 0.1 -0.3 -0.2 -0.0 -0.1 -0.0 -0.8 -0.2 0.2 -0.1 -0.1 -0.0 -0.1 0.1 0.1 -0.2 0.2 0.4 0.2 0.7 0.2 0.2 -0.3 -0.0 0.6 0.3 0.1 0.1 0.0
Past tobacco smoking 0.6 1.1 4.4 -1.5 -1.4 0.8 0.9 -0.5 -1.6 -1.2 0.9 0.7 -0.9 0.3 0.8 0.7 0.1 0.6 -0.9 0.9 0.6 2.1 -1.0 -0.4 -1.0 -0.9 -1.1 -1.1 -1.2 -1.2 -1.2 -1.0 -1.4
Alcohol usually taken with meals 0.9 1.5 4.6 -1.4 -1.7 -1.3 -1.0 -2.0 -1.0 0.5 -1.0 -1.1 -2.2 -1.7 -0.3 -1.4 -1.9 -1.4 -2.1 -1.0 -1.3 -0.2 1.0 1.3 1.0 1.0 0.7 1.0 0.3 0.8 0.9 0.9 -0.1
Nervous feelings 0.1 0.2 0.9 0.8 0.8 -0.1 -0.1 -0.3 0.1 0.3 -0.5 -0.1 0.7 0.2 -0.4 0.2 0.3 0.1 0.7 -0.1 -0.9 -0.2 0.1 0.7 0.0 0.1 -0.1 0.1 0.1 0.2 -0.0 0.1 0.5
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 5.0 -1.7 -1.5 1.3 1.3 -0.1 -1.7 -1.5 1.3 1.2 -0.7 0.8 1.1 1.1 0.5 0.9 -0.7 1.2 0.8 2.2 -1.4 -0.3 -1.4 -1.3 -1.6 -1.4 -1.5 -1.5 -1.3 -1.4 -1.7
Hearing difficulty/problems with background noise 2.2 3.5 6.8 -0.6 -0.2 2.3 2.3 0.7 -0.0 -2.2 1.7 2.3 0.7 2.1 2.6 1.8 2.0 2.0 0.9 2.4 2.2 2.0 -2.0 -1.3 -2.3 -2.3 -2.0 -2.1 -1.7 -1.9 -2.2 -2.2 -1.8
Hair/balding pattern: Pattern 2 0.3 0.4 1.8 -1.1 -1.3 -0.3 -0.2 -1.2 -1.0 -0.1 -0.3 -0.4 -1.3 -0.6 -0.1 -0.8 -0.9 -0.4 -1.3 -0.3 -0.8 -0.2 0.3 -0.3 0.2 0.2 0.5 0.1 0.1 0.1 0.3 0.1 -0.4
Had menopause 1.7 2.2 3.7 0.1 0.6 1.6 1.6 1.8 1.9 -1.3 1.1 1.6 1.4 1.8 1.5 1.6 1.8 1.7 1.3 1.8 1.6 0.7 -1.6 -1.6 -1.6 -1.6 -1.0 -1.5 -1.5 -1.5 -1.6 -1.5 -0.8
Had other major operations 1.6 1.9 3.9 1.2 0.9 -1.4 -1.6 0.2 0.7 1.6 -1.7 -1.5 0.1 -1.3 -2.0 -1.5 -1.0 -1.3 0.1 -1.6 -0.3 -1.9 1.5 0.5 1.6 1.6 1.7 1.5 1.6 1.6 1.6 1.6 1.8
Forced vital capacity (FVC) 5.7 21.8 35.1 0.9 -0.2 -5.2 -5.1 -5.3 -4.3 5.2 -5.9 -5.5 -2.5 -5.1 -4.7 -4.0 -4.8 -5.2 -2.5 -5.0 -5.1 -2.6 5.3 5.9 5.2 5.1 3.4 5.2 5.2 5.4 5.3 5.1 3.6
Heel bone mineral density (BMD) T-score, automated (right) 1.3 3.1 5.1 -1.3 -0.9 1.9 1.9 2.3 0.7 -2.0 2.2 1.9 -0.1 1.5 2.0 0.6 1.4 1.6 0.0 1.8 2.0 1.9 -1.9 -1.7 -2.1 -1.9 -1.8 -1.8 -2.0 -2.0 -2.1 -1.9 -2.1
Ever unenthusiastic/disinterested for a whole week 2.0 2.4 4.5 0.5 0.9 1.7 1.6 1.1 -0.6 -1.6 1.9 1.5 1.5 1.8 1.7 1.1 1.9 1.9 1.5 1.6 2.0 2.1 -1.7 -0.5 -1.6 -1.6 -1.6 -1.7 -1.3 -1.6 -2.1 -1.6 -1.0
Qualifications: None of the above 0.3 0.7 1.9 1.2 1.1 -0.7 -0.8 -0.3 0.6 1.1 -0.8 -0.6 0.7 -0.3 -0.9 -0.5 -0.1 -0.5 0.7 -0.7 -0.2 -1.4 0.9 0.4 0.8 0.8 0.3 0.9 1.0 0.9 1.3 0.9 1.0
Financial difficulties in last 2 years 1.2 1.6 5.4 -0.1 0.2 1.4 1.2 1.7 -0.2 -1.1 2.3 1.2 0.8 1.3 1.0 0.6 1.2 1.3 0.7 1.1 1.3 1.8 -1.5 -0.2 -1.2 -1.2 -2.2 -1.3 -1.6 -1.7 -0.9 -1.3 -0.9
Mouth/teeth dental problems 1.0 1.6 6.1 -1.9 -1.7 1.1 1.1 2.1 0.0 -1.6 1.2 1.0 -1.1 0.4 1.5 0.1 0.1 0.6 -1.2 0.9 2.5 1.6 -1.1 -1.3 -1.0 -1.1 -0.4 -1.0 -1.1 -1.2 -1.1 -1.2 -1.7
Heart attack 0.2 0.3 1.7 1.3 1.3 -0.2 -0.2 -0.1 0.8 0.4 -0.1 -0.1 1.1 0.3 -0.2 -0.1 0.5 0.1 1.1 -0.2 0.2 -0.8 0.2 0.2 0.2 0.2 -0.5 0.3 0.5 0.4 0.6 0.3 0.6
Allergy 0.2 0.4 1.8 0.7 0.5 -0.7 -0.7 0.5 0.8 0.9 -0.1 -0.7 0.0 -0.6 -0.2 -0.5 -0.4 -0.8 0.2 -0.8 -0.0 -0.9 0.7 0.1 0.5 0.7 1.4 0.9 0.2 0.5 -0.1 0.8 1.0
Pain all over the body in last month 2.1 2.3 9.5 3.1 3.1 -0.9 -1.0 0.9 2.3 1.6 -1.1 -0.8 2.4 0.2 -1.1 -0.2 0.7 -0.2 2.4 -0.9 0.1 -2.2 1.1 0.5 0.9 1.0 1.2 1.0 1.7 1.4 0.7 1.1 2.4
Diabetes (self-reported) 1.0 1.6 6.6 0.1 0.4 1.3 1.3 0.6 2.3 -1.1 1.5 1.4 1.0 1.5 1.4 1.2 1.4 1.3 1.0 1.2 0.8 -0.4 -1.2 -2.6 -1.4 -1.3 -0.2 -1.3 -1.0 -1.2 -1.5 -1.2 -0.8
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 2.3 0.9 0.7 -1.1 -1.0 -1.5 -0.9 1.1 -1.0 -0.9 0.1 -0.7 -1.4 -0.4 -0.6 -0.7 0.2 -1.0 -1.0 -0.8 0.9 1.2 1.1 1.0 0.1 0.8 1.4 1.1 1.3 0.9 1.0
Medication: Ramipril 0.3 0.4 1.2 -0.5 -0.4 0.7 0.7 0.3 0.5 -0.9 0.1 0.8 -0.0 0.6 0.7 0.3 0.5 0.5 -0.0 0.7 1.1 0.3 -0.6 -0.6 -0.7 -0.7 -0.5 -0.6 -0.6 -0.5 -0.7 -0.7 -0.8
Medication: Simvastatin 0.6 0.9 1.9 0.6 0.9 1.2 1.0 0.6 0.7 -0.9 0.6 1.1 1.3 1.3 1.3 1.0 1.4 1.2 1.2 1.0 0.8 0.8 -0.7 -0.6 -1.0 -1.0 -0.7 -0.9 -0.5 -0.6 -1.1 -0.8 -0.2
Fluid intelligence score 0.5 1.0 2.8 1.1 1.4 0.8 0.7 1.4 1.0 -0.5 0.9 0.9 1.7 1.3 1.0 1.4 1.4 1.1 1.6 0.8 0.7 -0.3 -0.9 -0.6 -0.8 -0.7 -0.8 -0.8 -0.9 -0.9 -0.6 -0.7 0.2
Illnesses of siblings 4.4 6.2 10.9 1.6 1.0 -2.9 -2.9 -1.2 -1.4 3.1 -3.3 -2.8 -0.4 -2.5 -3.0 -2.2 -2.2 -2.6 -0.4 -2.9 -1.4 -1.8 2.9 2.8 2.9 2.9 2.0 2.8 3.3 3.1 2.8 2.9 2.6
Neuroticism score 0.1 0.2 1.1 0.8 0.8 -0.1 -0.1 1.1 1.0 0.4 -0.5 -0.1 0.7 0.1 -0.2 0.0 0.3 0.1 0.8 -0.1 -0.6 -0.3 0.1 1.0 0.1 0.1 -0.3 0.1 0.1 0.2 0.1 0.1 0.6
Weight 0.1 0.5 2.2 1.4 1.5 0.0 0.0 0.3 1.1 0.8 -0.8 -0.1 1.3 0.5 -0.8 -0.0 0.7 0.3 1.4 0.1 -0.1 -1.1 0.3 0.4 0.1 -0.0 -0.3 0.2 1.0 0.7 0.7 0.1 0.7
Impedance of arm (right) 1.0 4.5 8.4 1.8 1.3 -2.5 -2.5 -0.2 -0.1 2.4 -2.4 -2.5 0.0 -2.0 -1.5 -2.0 -1.7 -2.3 -0.0 -2.5 -1.5 -2.4 2.5 1.8 2.5 2.5 2.9 2.5 2.6 2.6 2.0 2.5 2.6
Arm fat percentage (right) 1.6 6.3 20.3 -0.2 0.5 3.0 2.8 4.5 2.7 -2.5 2.1 2.9 1.6 2.9 2.0 1.9 2.9 3.0 1.7 2.8 3.1 1.0 -2.7 -2.9 -2.8 -2.8 -2.0 -2.8 -2.1 -2.5 -2.3 -2.8 -1.7
Trunk fat-free mass 0.8 4.8 12.8 2.0 1.6 -2.2 -2.1 -3.6 -1.0 2.9 -2.8 -2.2 0.6 -1.4 -2.7 -1.0 -1.2 -1.8 0.6 -2.0 -2.8 -2.2 2.4 2.8 2.2 2.1 0.9 2.3 2.8 2.7 2.6 2.3 2.3
Hip circumference 0.3 1.5 12.1 1.9 2.1 0.5 0.4 3.5 2.1 0.4 -0.5 0.2 2.1 1.1 -0.6 -0.0 1.4 0.9 2.1 0.5 1.3 -1.2 -0.1 -0.2 -0.3 -0.4 -0.3 -0.2 0.8 0.4 0.1 -0.2 0.9
Time employed in main current job 1.9 2.2 3.8 -1.3 -1.1 1.7 1.7 1.8 0.7 -1.9 1.6 1.6 -0.3 1.3 1.8 0.9 1.1 1.3 -0.2 1.7 1.5 1.8 -1.6 -1.0 -1.7 -1.7 -1.0 -1.5 -1.9 -1.8 -1.9 -1.6 -1.8
Alcohol intake versus 10 years previously 0.1 0.2 1.2 0.4 0.5 0.3 0.3 0.8 1.1 -0.2 -0.1 0.4 0.6 0.5 0.2 0.4 0.5 0.5 0.6 0.1 0.5 -0.3 -0.5 -0.5 -0.2 -0.3 -0.8 -0.4 -0.2 -0.4 0.2 -0.4 -0.2
Father’s age at death 0.4 0.5 1.8 0.7 0.6 -0.9 -0.8 -0.9 0.5 0.7 -0.5 -0.7 0.3 -0.5 -0.4 -1.2 -0.4 -0.6 0.3 -0.8 -0.5 -0.6 0.8 1.3 0.9 0.8 0.3 0.8 0.7 0.8 0.9 0.8 0.8
Worrier / anxious feelings 0.2 0.5 2.3 1.5 1.5 -0.2 -0.3 0.3 0.1 0.7 -0.6 -0.4 1.2 0.3 0.2 0.0 0.6 0.0 1.4 -0.2 -0.7 -0.1 0.3 1.4 0.3 0.2 -0.4 0.3 0.4 0.5 0.2 0.3 1.0
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 5.1 -1.8 -1.6 1.3 1.4 -0.4 -1.5 -1.5 1.0 1.3 -0.8 0.8 0.6 0.8 0.5 1.1 -0.8 1.4 0.5 2.3 -1.4 -0.4 -1.4 -1.4 -1.8 -1.4 -1.4 -1.4 -1.2 -1.5 -2.0
Falls in the last year 0.2 0.2 2.3 0.0 0.1 0.2 0.2 1.4 1.5 0.0 -0.0 0.2 0.0 0.2 -0.2 -0.4 0.1 0.2 0.0 0.1 -0.0 -0.8 -0.1 -0.9 -0.0 -0.2 0.3 -0.1 0.1 0.0 0.5 -0.2 -0.0
Hair/balding pattern: Pattern 3 0.9 1.3 2.5 -1.3 -1.1 1.2 1.3 1.2 0.0 -1.3 1.1 1.3 -0.5 0.8 1.4 1.5 0.6 0.9 -0.5 1.4 0.1 1.3 -1.2 -0.9 -1.3 -1.3 -1.0 -1.1 -1.3 -1.2 -1.2 -1.3 -1.6
Number of live births 0.7 1.0 2.3 0.6 0.8 1.1 1.0 0.6 0.1 -0.7 1.5 1.0 1.3 1.3 0.9 1.4 1.4 1.1 1.2 1.1 1.1 0.6 -0.9 -0.8 -1.1 -1.0 -1.0 -0.8 -0.5 -0.8 -1.1 -0.9 -0.5
Forced expiratory volume in 1-second (FEV1) 3.9 13.1 21.7 -0.1 -1.1 -3.9 -3.8 -4.4 -4.7 3.8 -4.2 -4.2 -2.8 -4.2 -3.4 -2.8 -4.1 -4.1 -2.7 -3.7 -4.3 -1.2 4.0 4.5 3.9 3.8 2.3 3.9 3.9 3.9 4.1 3.8 2.2
Pulse rate 0.1 0.1 0.8 0.3 0.2 0.1 -0.2 0.4 0.3 0.4 -0.3 -0.2 0.1 -0.1 -0.7 -0.6 -0.0 -0.1 0.2 -0.1 0.3 -0.3 0.1 -0.9 0.3 0.2 0.2 0.1 0.7 0.2 0.9 0.1 0.3
Happiness 0.2 0.2 0.7 0.5 0.6 0.4 0.3 0.6 -0.5 -0.1 0.5 0.3 0.8 0.5 0.5 0.5 0.6 0.5 0.8 0.3 0.6 0.7 -0.3 0.2 -0.3 -0.3 -0.8 -0.3 0.2 -0.2 -0.1 -0.3 -0.1
Noisy workplace 2.7 3.4 5.5 0.8 0.4 -2.3 -2.2 -1.5 -1.9 2.1 -1.9 -2.1 -0.6 -2.0 -2.1 -1.7 -1.8 -2.0 -0.6 -2.2 -1.5 -1.3 2.0 1.4 2.2 2.2 1.5 2.0 2.3 1.9 2.1 2.1 1.6
Qualifications: A levels/AS levels or equivalent 0.6 1.3 3.5 -0.6 -0.3 1.1 1.2 -0.7 -0.8 -1.3 1.6 1.3 0.3 1.1 1.9 0.7 1.0 1.1 0.2 1.3 0.5 1.3 -1.2 0.1 -1.2 -1.2 -1.8 -1.3 -1.5 -1.4 -1.0 -1.2 -1.3
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 2.9 -0.4 -0.5 -0.5 -0.4 -1.7 0.9 -0.1 -0.7 -0.2 -0.7 -0.7 -0.3 -0.1 -0.6 -0.4 -0.6 -0.5 -1.0 -1.1 0.3 -0.1 0.5 0.4 1.1 0.2 -0.1 0.2 0.3 0.3 0.2
Mouth/teeth dental problems: Dentures 4.9 8.2 20.5 2.0 1.4 -3.0 -3.0 -4.5 -0.6 3.4 -3.1 -3.1 -0.0 -2.4 -3.5 -1.6 -2.1 -2.8 -0.1 -2.8 -4.5 -3.2 3.2 2.5 3.0 3.0 2.1 3.2 3.1 3.4 3.5 3.1 2.9
Asthma 0.8 1.5 5.4 -0.2 -0.5 -1.4 -1.2 -0.9 -0.7 1.0 -1.7 -1.1 -1.0 -1.3 -1.5 -0.7 -1.4 -1.3 -1.1 -1.0 -2.3 -0.6 1.3 1.8 1.4 1.2 0.1 1.2 1.3 1.4 2.0 1.2 0.5
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.1 0.2 -0.5 -0.5 0.3 0.2 -0.4 -0.3 -0.0 -0.4 0.2 -0.3 0.1 -0.3 -0.3 0.0 0.1 -0.3 0.3 0.3 0.2 -0.1 -0.0 -0.2 -0.2 -0.0 -0.3 -0.2 -0.1 0.0 -0.2 -0.1
Medication: Cholesterol lowering 0.3 0.4 4.1 1.0 1.1 0.0 0.1 0.8 2.0 -0.2 -0.4 0.4 1.1 0.6 0.2 -0.1 0.7 0.3 1.1 -0.1 -0.0 -1.0 0.1 -0.7 -0.2 -0.1 0.4 -0.0 0.5 0.3 -0.5 0.0 0.4
Depression (self-reported) 0.1 0.2 1.1 -0.7 -0.7 -0.1 0.0 -0.5 0.1 -0.2 0.0 -0.1 -0.6 -0.3 -0.4 -1.0 -0.3 -0.1 -0.6 -0.0 -0.2 0.5 -0.2 0.2 -0.1 -0.0 -0.3 -0.1 -0.5 -0.2 -0.2 -0.1 -0.4
Medication: Lansoprazole 0.7 0.8 1.9 -0.5 -0.3 1.1 1.1 0.4 -0.7 -1.0 0.7 1.0 0.3 1.0 0.6 1.4 0.8 1.0 0.2 1.2 0.4 1.2 -0.9 -0.7 -1.1 -1.1 -0.8 -1.0 -0.9 -0.9 -1.4 -1.0 -0.9
Prospective memory result 0.1 0.1 0.8 -0.4 -0.4 0.1 0.1 -0.9 0.5 0.2 -0.4 0.1 -0.2 -0.1 0.3 0.1 -0.1 -0.0 -0.3 0.1 -0.4 -0.4 0.1 -0.5 0.0 -0.1 0.6 -0.1 0.2 0.2 0.1 -0.0 0.1
Lung cancer (father) 1.0 1.1 2.6 -0.2 0.1 1.2 1.2 0.8 1.3 -1.0 1.0 1.2 0.7 1.3 0.6 1.5 1.2 1.4 0.7 1.2 0.3 0.4 -1.2 -1.2 -1.3 -1.2 -0.6 -1.2 -1.1 -1.1 -1.6 -1.2 -0.8
Illnesses of mother 0.6 0.8 2.6 -0.6 -0.4 0.9 0.9 0.3 0.3 -1.0 1.5 1.0 0.2 0.8 0.7 0.5 0.7 0.8 0.1 0.9 1.4 0.2 -0.9 -1.6 -1.0 -0.9 -0.6 -0.9 -1.0 -1.0 -1.1 -0.9 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 2.7 8.8 15.6 -0.1 -0.9 -3.1 -3.0 -3.7 -3.9 3.1 -3.5 -3.5 -2.2 -3.3 -2.8 -1.9 -3.2 -3.3 -2.2 -2.9 -3.8 -0.9 3.3 4.0 3.1 3.0 1.5 3.1 3.3 3.2 3.6 3.0 1.7
Pulse wave Arterial Stiffness index 3.4 3.9 6.1 1.0 0.6 -2.3 -2.3 -1.2 -0.2 2.4 -2.2 -2.3 -0.3 -2.0 -2.2 -1.9 -1.8 -2.1 -0.4 -2.2 -2.1 -1.9 2.2 2.1 2.4 2.3 1.9 2.2 2.3 2.3 2.5 2.3 2.2
Impedance of arm (left) 1.1 5.0 10.2 2.8 2.4 -2.5 -2.5 -0.1 0.5 2.6 -2.5 -2.5 1.0 -1.6 -1.5 -1.6 -1.2 -2.1 1.0 -2.5 -1.1 -2.7 2.5 2.0 2.5 2.5 2.8 2.5 2.8 2.7 2.0 2.6 3.2
Arm fat mass (right) 0.7 2.8 6.8 0.3 0.8 2.0 1.9 2.6 2.1 -1.4 1.2 1.9 1.5 2.1 1.0 1.4 2.2 2.1 1.6 2.0 1.9 0.3 -1.8 -1.9 -1.9 -1.9 -1.5 -1.8 -1.1 -1.4 -1.3 -1.8 -1.0
Trunk predicted mass 0.8 4.8 13.4 2.0 1.6 -2.2 -2.1 -3.7 -1.1 2.9 -2.7 -2.2 0.6 -1.4 -2.6 -1.0 -1.2 -1.8 0.5 -1.9 -2.8 -2.1 2.4 2.9 2.1 2.1 0.9 2.3 2.8 2.7 2.6 2.3 2.3
Standing height 5.3 52.9 82.3 5.9 4.4 -8.2 -8.0 -7.9 -2.5 9.1 -8.2 -8.2 0.4 -6.2 -7.3 -5.6 -5.3 -7.2 0.3 -7.9 -7.5 -7.3 8.5 8.1 8.2 8.0 6.1 8.3 9.0 9.0 8.2 8.4 8.1
Length of working week for main job 2.2 2.5 6.8 -2.6 -2.4 1.4 1.4 -0.8 -0.7 -1.9 1.5 1.5 -1.5 0.6 1.6 0.6 0.2 1.1 -1.5 1.3 -0.0 2.2 -1.7 -1.1 -1.5 -1.4 -1.5 -1.6 -2.4 -2.0 -1.3 -1.7 -2.2
Exposure to tobacco smoke at home 3.9 4.4 8.0 -2.5 -2.1 2.3 2.3 1.4 0.0 -2.6 2.4 2.3 -0.9 1.6 2.1 1.4 1.1 1.8 -1.0 2.3 1.9 1.9 -2.3 -2.8 -2.4 -2.3 -1.1 -2.4 -2.8 -2.6 -2.5 -2.3 -2.7
Breastfed as a baby 1.4 1.7 4.6 1.6 1.3 -1.4 -1.4 0.5 1.8 1.4 -1.5 -1.4 0.5 -0.9 -1.2 -0.7 -0.6 -1.0 0.6 -1.4 -1.1 -2.2 1.2 0.8 1.6 1.4 1.4 1.2 1.2 1.3 1.7 1.3 1.9
Tense / ‘highly strung’ 1.1 1.8 3.7 0.2 -0.2 -1.5 -1.5 -1.4 -0.7 1.4 -1.9 -1.6 -0.9 -1.6 -1.5 -1.2 -1.4 -1.5 -0.8 -1.4 -1.8 -1.0 1.4 1.6 1.6 1.5 1.1 1.4 1.4 1.5 1.7 1.4 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.9 3.6 0.5 0.9 1.5 1.5 1.4 1.0 -1.1 1.0 1.3 1.6 1.8 1.3 1.1 1.9 1.9 1.6 1.3 1.6 0.8 -1.5 -0.5 -1.4 -1.5 -1.7 -1.6 -1.3 -1.3 -1.3 -1.5 -0.5
Hair/balding pattern: Pattern 4 0.4 1.0 5.4 0.1 -0.1 -1.1 -0.9 -2.3 -1.4 0.9 -1.0 -0.7 -0.6 -0.9 -0.8 -0.4 -0.9 -0.9 -0.6 -1.0 -2.1 -0.8 0.9 1.4 1.0 0.9 0.3 0.9 0.3 0.8 1.1 0.9 0.5
Birth weight of first child 0.2 0.4 6.0 -0.3 -0.3 0.2 0.2 1.5 -0.2 -0.3 0.9 0.2 -0.3 0.1 0.9 -0.4 -0.0 0.1 -0.3 0.1 2.5 0.6 -0.2 -0.4 -0.4 -0.2 0.0 -0.1 -0.2 -0.3 -0.7 -0.2 -0.4
Peak expiratory flow (PEF) 0.4 0.9 4.7 -1.4 -1.6 -0.4 -0.3 -1.9 -2.2 0.1 -0.1 -0.6 -1.7 -1.0 0.2 -0.1 -1.1 -0.7 -1.7 -0.3 -1.2 0.9 0.4 0.5 0.3 0.3 0.1 0.4 0.4 0.3 0.5 0.3 -0.7
Pulse wave reflection index 2.7 3.3 6.1 -0.3 -0.8 -2.3 -2.0 -1.5 -1.4 1.8 -1.5 -2.0 -1.6 -2.2 -1.6 -1.9 -2.3 -2.3 -1.7 -2.1 -1.4 -1.3 2.1 2.5 2.1 2.0 1.7 2.2 1.4 1.9 1.9 2.1 1.2
Ever highly irritable/argumentative for 2 days 0.9 1.0 1.8 0.7 0.4 -1.3 -1.3 0.1 0.3 1.2 -0.3 -1.1 -0.3 -1.2 -0.9 -1.1 -1.0 -1.1 -0.2 -1.3 -0.2 -1.3 1.1 0.6 1.3 1.3 1.2 1.3 1.0 1.0 1.3 1.3 1.0
Loud music exposure frequency 0.2 0.2 2.9 0.8 0.8 0.0 -0.1 0.5 1.7 0.2 -0.4 -0.2 0.6 0.1 -0.3 0.0 0.3 0.1 0.6 -0.0 0.2 -0.9 0.2 -0.5 0.1 0.1 0.6 0.1 0.2 0.2 0.1 0.2 0.5
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.6 -0.1 -0.0 0.3 0.3 -0.0 -0.4 -0.4 0.4 0.2 0.2 0.3 0.5 0.1 0.3 0.4 0.1 0.3 0.5 0.7 -0.6 0.0 -0.4 -0.3 -0.1 -0.6 -0.7 -0.6 -0.8 -0.4 -0.1
Mouth/teeth dental problems: Bleeding gums 2.2 2.8 4.3 -0.4 -0.0 1.9 1.9 1.8 0.8 -1.8 1.7 1.9 0.8 1.8 1.6 1.8 1.8 2.0 0.9 1.9 1.7 1.5 -2.0 -1.4 -1.9 -1.9 -1.4 -2.0 -2.0 -2.0 -2.1 -1.9 -1.3
Blood clot in the leg (DVT) 0.4 0.6 1.3 -0.1 0.2 1.1 1.0 0.4 0.3 -0.9 0.5 0.9 0.6 1.0 0.4 0.6 1.0 1.0 0.6 0.9 0.7 0.9 -0.9 -0.3 -0.9 -1.0 -0.7 -1.0 -0.8 -0.8 -0.8 -1.0 -0.4
Medication: Paracetamol 1.3 2.1 3.8 0.8 0.5 -1.6 -1.6 -0.9 -1.3 1.7 -1.7 -1.8 -0.3 -1.4 -1.9 -1.7 -1.2 -1.5 -0.3 -1.6 -1.6 -0.8 1.7 1.9 1.5 1.6 1.0 1.6 1.7 1.8 1.5 1.6 1.4
Headache pain in last month 1.0 1.7 4.0 2.0 1.8 -1.4 -1.3 -0.4 0.2 1.7 -1.5 -1.4 1.0 -0.7 -1.9 -1.1 -0.4 -0.8 1.0 -1.3 0.4 -1.7 1.3 1.4 1.2 1.3 0.9 1.3 1.4 1.4 1.1 1.4 1.9
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.8 -0.9 -0.8 0.6 0.5 -0.2 -1.3 -0.4 0.8 0.2 -0.4 0.2 0.3 0.8 0.1 0.4 -0.5 0.6 0.4 1.3 -0.7 0.0 -0.4 -0.5 -0.6 -0.6 -0.9 -0.8 -0.3 -0.6 -0.7
Glaucoma (self-reported) 1.2 1.4 3.0 1.7 1.5 -1.4 -1.3 -0.2 -0.1 1.5 -1.2 -1.3 0.8 -0.7 -1.2 -1.3 -0.4 -1.1 0.8 -1.2 -0.1 -1.2 1.4 1.5 1.2 1.3 0.6 1.3 1.7 1.6 1.0 1.4 1.4
Gout (self-reported) 1.7 2.4 5.7 1.5 1.2 -1.7 -1.8 -0.2 0.7 2.0 -1.3 -1.8 0.3 -1.3 -1.7 -1.1 -1.0 -1.4 0.3 -1.7 -1.0 -2.4 1.7 0.1 1.7 1.8 2.0 1.7 2.2 1.9 1.6 1.8 1.8
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 3.3 -0.2 -0.2 0.0 0.0 1.8 0.7 0.2 -0.7 -0.0 -0.2 0.0 -0.6 -0.6 -0.1 0.0 -0.2 0.1 0.4 -0.2 0.1 0.1 0.1 -0.0 -0.0 -0.0 0.3 0.3 0.5 -0.1 0.1
Medication: Amlodipine 0.2 0.2 1.1 -0.7 -0.8 -0.2 -0.2 0.0 -0.0 0.1 -0.0 -0.0 -0.9 -0.5 0.0 -0.2 -0.6 -0.5 -0.8 -0.2 -0.4 -0.8 0.3 -1.0 0.1 0.2 0.8 0.3 -0.2 -0.0 0.2 0.2 -0.2
Medication: Ventolin 100micrograms inhaler 1.0 1.3 3.4 0.6 0.9 1.1 1.2 0.6 -0.1 -1.1 0.9 1.1 1.4 1.6 0.5 1.4 1.5 1.5 1.3 1.1 1.1 1.6 -1.3 0.3 -1.1 -1.2 -1.9 -1.3 -0.6 -0.9 -1.1 -1.2 -0.7
Birth weight 0.6 1.3 3.5 -1.4 -1.2 1.1 1.3 -0.0 0.2 -1.4 0.9 1.4 -0.4 1.0 1.9 1.0 0.6 1.0 -0.5 1.4 1.4 0.9 -1.2 -0.9 -1.2 -1.3 -1.3 -1.3 -1.1 -1.2 -1.1 -1.3 -1.7
Chronic bronchitis/emphysema (mother) 2.5 3.0 7.5 -0.3 0.1 2.0 2.0 0.6 2.4 -1.8 1.6 2.0 1.0 2.0 1.8 2.7 1.9 2.0 1.0 2.1 0.8 0.8 -1.9 -1.9 -1.9 -2.0 -1.6 -1.9 -1.5 -1.7 -1.6 -1.9 -1.3
High blood pressure (siblings) 0.9 1.3 3.1 -1.6 -1.4 1.0 1.1 -0.4 0.6 -1.5 1.2 1.0 -0.7 0.6 1.3 0.7 0.4 0.8 -0.7 1.2 -0.8 0.5 -1.3 -1.7 -1.1 -1.1 -0.5 -1.2 -1.8 -1.5 -1.2 -1.3 -1.4
Forced vital capacity (FVC), Best measure 3.4 12.5 24.4 0.6 -0.3 -3.9 -3.7 -4.4 -3.8 3.9 -4.5 -4.1 -2.0 -3.7 -3.5 -2.5 -3.6 -3.9 -1.9 -3.7 -4.4 -1.6 4.0 4.9 3.8 3.7 1.9 3.8 4.0 4.1 4.2 3.7 2.5
Body fat percentage 1.4 5.5 22.7 0.4 1.0 2.6 2.5 4.8 3.1 -2.0 2.0 2.5 2.0 2.7 1.8 1.4 2.8 2.7 2.0 2.5 3.2 0.6 -2.4 -2.6 -2.4 -2.5 -1.7 -2.4 -1.6 -2.1 -2.0 -2.4 -1.2
Leg fat percentage (right) 3.3 11.8 29.7 -0.3 0.6 4.0 3.9 5.5 3.4 -3.5 3.6 3.9 2.2 4.0 3.1 2.5 3.9 4.0 2.3 3.9 4.0 1.8 -3.7 -3.7 -3.7 -3.9 -3.0 -3.7 -3.2 -3.5 -3.3 -3.7 -2.6
Arm fat-free mass (right) 0.4 2.0 6.7 1.7 1.5 -1.2 -1.2 -2.6 -0.3 2.0 -1.7 -1.3 0.9 -0.6 -1.9 -0.6 -0.4 -0.8 0.9 -1.1 -1.6 -1.4 1.5 1.9 1.2 1.2 0.1 1.4 1.9 1.8 1.7 1.4 1.6
Exposure to tobacco smoke outside home 0.7 0.9 4.5 1.7 1.8 0.2 0.1 2.1 1.7 0.2 -0.1 0.4 1.7 0.8 0.0 0.2 1.0 0.4 1.8 0.1 0.5 -1.7 -0.0 -1.0 -0.3 -0.1 0.4 -0.0 0.1 0.2 -0.3 0.0 0.9
Comparative body size at age 10 1.4 3.8 6.9 -1.7 -1.3 2.3 2.3 1.7 0.3 -2.4 1.7 2.2 -0.2 1.8 2.1 1.5 1.5 2.0 -0.1 2.4 2.6 1.7 -2.2 -1.6 -2.3 -2.3 -2.3 -2.2 -2.3 -2.2 -1.8 -2.3 -2.4
Number of full brothers 0.1 0.1 0.4 0.5 0.5 -0.2 -0.2 -0.6 -0.2 0.3 0.4 -0.1 0.4 0.1 -0.3 -0.3 0.1 -0.1 0.4 -0.2 -0.4 -0.4 0.1 0.2 0.2 0.2 -0.2 0.2 0.2 0.1 0.4 0.2 0.3
Worry too long after embarrassment 0.7 1.2 4.0 1.3 1.1 -1.2 -1.1 1.2 0.5 1.4 -1.5 -1.1 0.6 -0.6 -0.6 -1.3 -0.4 -0.8 0.6 -1.1 -0.2 -1.0 1.1 2.0 1.3 1.1 0.8 1.0 1.5 1.3 1.2 1.1 1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.8 -0.7 -0.6 0.7 0.7 0.5 -0.0 -0.7 0.4 0.7 -0.2 0.4 0.6 0.2 0.4 0.7 -0.2 0.8 0.9 0.8 -0.7 -0.2 -0.7 -0.7 -0.7 -0.8 -0.9 -0.8 -0.6 -0.8 -0.7
Wheeze or whistling in the chest in last year 0.7 1.3 3.5 1.3 1.2 -1.1 -1.1 1.7 1.3 1.1 -1.6 -1.0 0.9 -0.5 -1.4 -1.3 -0.4 -0.5 0.7 -1.1 0.0 -1.2 0.9 0.6 1.2 1.1 0.6 0.7 1.9 1.3 1.4 0.9 1.4
Number of children fathered 0.3 0.4 1.4 -1.1 -1.2 -0.3 -0.3 -1.0 -1.1 -0.1 0.5 -0.2 -1.2 -0.6 -0.4 -0.3 -0.8 -0.6 -1.1 -0.2 -1.1 0.5 0.3 -0.1 0.1 0.2 0.1 0.4 -0.2 -0.1 -0.1 0.3 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 3.8 1.0 0.8 -1.4 -1.3 -0.7 1.1 1.5 -0.9 -1.2 0.1 -1.0 -1.1 -0.8 -0.8 -1.2 0.2 -1.1 -1.3 -2.0 1.4 0.8 1.3 1.3 1.2 1.4 1.3 1.4 1.5 1.4 1.3
Age at first live birth 0.4 0.6 3.4 0.8 0.7 -0.8 -0.8 -1.9 0.3 0.6 -1.2 -0.6 0.2 -0.5 -0.1 -1.0 -0.4 -0.5 0.3 -0.9 -0.7 -0.7 0.7 1.1 0.8 0.8 0.5 0.7 0.9 0.9 0.8 0.7 1.0
Pulse wave peak to peak time 2.0 2.4 3.8 -0.6 -0.3 1.8 1.8 0.6 0.1 -1.9 1.7 1.8 0.4 1.6 1.8 1.7 1.5 1.6 0.4 1.8 1.5 1.5 -1.7 -1.5 -1.9 -1.8 -1.6 -1.7 -1.7 -1.8 -2.0 -1.7 -1.7
Health satisfaction 1.0 1.4 2.5 -0.3 0.0 1.4 1.3 0.5 0.2 -1.4 1.6 1.3 0.7 1.3 1.3 0.8 1.3 1.4 0.7 1.4 0.8 1.4 -1.3 -1.0 -1.3 -1.3 -1.5 -1.4 -1.0 -1.3 -1.0 -1.3 -1.2
Shortness of breath walking on level ground 0.1 0.1 1.2 0.4 0.4 -0.0 -0.1 1.1 0.1 -0.1 0.4 -0.0 0.5 0.1 -0.1 -0.3 0.2 0.2 0.4 -0.3 0.8 -0.2 -0.2 -0.4 0.2 0.1 -0.1 -0.1 -0.2 -0.2 0.2 -0.0 0.1
Qualifications: College or University degree 0.1 0.4 1.7 -0.1 0.0 0.6 0.6 0.3 0.1 -0.6 1.0 0.8 0.3 0.6 1.1 0.3 0.5 0.6 0.2 0.6 0.8 0.3 -0.6 -1.3 -0.7 -0.6 0.0 -0.6 -0.1 -0.6 -1.0 -0.6 -0.6
Eye problems/disorders: None of the above 2.2 2.5 6.5 -2.5 -2.3 1.4 1.4 -0.2 -1.8 -1.8 1.5 1.4 -1.4 0.6 1.6 1.6 0.2 1.0 -1.5 1.4 -1.0 2.5 -1.5 -0.5 -1.3 -1.4 -1.9 -1.4 -2.0 -1.9 -1.0 -1.5 -2.3
Mouth/teeth dental problems: Loose teeth 0.2 0.2 1.1 1.0 1.0 -0.0 -0.1 0.4 -0.0 0.2 -0.6 -0.1 0.9 0.2 -0.7 0.4 0.4 0.2 0.9 -0.1 0.2 -0.5 0.2 0.0 0.0 0.1 0.5 0.2 0.5 0.5 -0.3 0.2 0.7
Emphysema/chronic bronchitis 0.5 0.6 2.4 0.9 0.8 -0.6 -0.6 0.3 1.5 0.5 -1.6 -0.6 0.6 -0.3 -0.8 -1.0 -0.2 -0.3 0.5 -0.7 0.5 -1.2 0.6 0.2 0.7 0.6 1.1 0.4 0.7 0.8 0.5 0.6 1.1
Medication for pain relief, constipation, heartburn 0.1 0.2 0.7 -0.4 -0.3 0.1 0.2 0.5 0.0 -0.6 0.9 0.4 -0.1 0.2 0.7 0.7 0.1 0.3 -0.1 0.2 0.2 0.5 -0.5 -0.5 -0.3 -0.2 -0.5 -0.4 -0.6 -0.7 -0.6 -0.3 -0.6
Neck or shoulder pain in last month 0.4 0.5 1.8 -1.3 -1.3 0.3 0.3 -0.6 -0.7 -0.6 0.9 0.4 -1.1 -0.2 0.0 -0.8 -0.4 0.1 -1.1 0.2 1.3 0.9 -0.4 -0.5 -0.4 -0.3 -0.5 -0.3 -1.2 -0.7 -0.4 -0.4 -0.8
Medication: Blood pressure 0.7 1.2 2.6 0.6 0.3 -1.3 -1.2 -1.1 0.3 1.0 -1.6 -0.9 -0.4 -1.1 -1.0 -1.4 -1.0 -1.2 -0.3 -1.3 -1.1 -1.5 1.4 1.1 1.1 1.2 1.0 1.3 1.3 1.4 1.2 1.3 1.0
Angina (self-reported) 1.1 1.5 2.6 -0.4 -0.0 1.6 1.5 0.3 1.2 -1.5 0.7 1.5 0.7 1.5 1.0 1.1 1.4 1.6 0.6 1.5 0.9 0.7 -1.4 -1.5 -1.5 -1.5 -1.1 -1.5 -1.0 -1.2 -1.3 -1.5 -1.1
Migraine (self-reported) 0.4 0.5 2.7 -1.4 -1.6 -0.3 -0.2 -0.1 -0.6 -0.1 -0.2 -0.2 -1.6 -0.8 -0.2 -0.6 -1.0 -0.5 -1.6 -0.3 0.1 0.3 0.3 0.3 0.2 0.2 0.5 0.2 -0.4 0.0 0.2 0.2 -0.4
Medication: Ibuprofen 0.0 0.0 0.3 -0.1 -0.1 0.2 0.2 -0.2 0.5 0.0 -0.6 0.2 0.0 0.2 -0.3 0.1 0.1 0.1 -0.0 0.3 0.2 -0.2 0.0 0.1 -0.1 -0.2 0.1 -0.2 -0.0 0.1 0.1 -0.1 0.1
Medication: Allopurinol 1.3 1.7 4.2 0.4 0.1 -1.5 -1.5 -0.4 0.6 1.6 -0.8 -1.5 -0.6 -1.4 -1.4 -0.6 -1.4 -1.6 -0.6 -1.5 -1.1 -2.0 1.5 -0.4 1.5 1.5 2.0 1.5 1.7 1.4 1.4 1.5 1.1
Medication: Omeprazole 0.1 0.2 0.5 -0.5 -0.5 0.4 0.4 0.2 -0.2 -0.4 0.6 0.4 -0.5 0.2 0.7 -0.6 0.1 0.2 -0.3 0.4 0.0 0.6 -0.3 -0.2 -0.4 -0.4 -0.3 -0.3 -0.2 -0.4 -0.3 -0.4 -0.6
Medication: Seretide 50 evohaler 1.1 1.3 3.0 0.4 0.7 1.4 1.3 1.7 1.2 -1.0 1.0 1.1 1.3 1.5 0.8 0.7 1.6 1.4 1.3 1.3 0.7 0.8 -1.1 -1.3 -1.2 -1.3 -0.8 -1.3 -0.5 -0.8 -1.2 -1.2 -0.5
Mean time to correctly identify matches 0.1 0.2 1.9 0.6 0.8 0.1 0.1 0.2 1.4 -0.0 -0.2 0.1 0.9 0.5 0.1 0.3 0.5 0.2 0.8 -0.0 0.1 -0.4 -0.1 -0.4 -0.1 -0.1 0.2 -0.1 0.2 0.1 -0.3 -0.1 0.2
Heart disease (mother) 0.6 0.7 3.8 1.9 2.0 -0.2 -0.3 1.0 0.1 0.6 -0.4 -0.4 1.7 0.4 -0.4 -0.3 0.7 0.3 1.7 -0.2 1.0 0.2 0.2 1.1 0.3 0.3 -0.3 0.2 0.9 0.5 0.0 0.3 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 2.3 -0.2 -0.3 -0.4 -0.3 -1.5 -1.1 0.3 -0.3 -0.3 -0.3 -0.3 -0.9 0.1 -0.4 -0.4 -0.4 -0.2 -0.9 -0.4 0.3 -0.2 0.3 0.3 0.5 0.3 0.3 0.2 0.3 0.3 -0.0
Whole body fat mass 0.4 1.8 8.4 1.0 1.3 1.4 1.3 2.9 2.2 -0.7 0.8 1.3 1.7 1.7 0.6 0.7 1.8 1.6 1.8 1.3 1.7 -0.2 -1.1 -1.3 -1.2 -1.3 -1.0 -1.2 -0.3 -0.8 -0.8 -1.2 -0.3
Leg fat mass (right) 1.1 4.4 11.0 0.1 0.6 2.5 2.4 3.3 2.0 -1.9 2.0 2.4 1.6 2.5 1.6 1.6 2.5 2.6 1.6 2.4 2.3 1.1 -2.3 -2.1 -2.3 -2.4 -2.1 -2.3 -1.6 -2.0 -1.8 -2.3 -1.5
Arm predicted mass (right) 0.6 3.0 7.0 2.1 1.8 -1.6 -1.6 -2.6 -0.2 2.4 -2.0 -1.6 1.0 -0.8 -2.3 -0.8 -0.6 -1.1 1.0 -1.4 -1.8 -1.8 1.8 2.2 1.6 1.6 0.4 1.8 2.3 2.2 2.1 1.7 2.0
Pulse rate, automated reading 0.2 0.8 3.3 0.6 0.5 -0.5 -0.9 0.4 -0.2 1.1 -1.1 -0.8 0.2 -0.7 -1.4 -1.8 -0.5 -0.7 0.2 -0.7 0.7 -0.5 0.9 0.3 0.9 0.9 0.7 0.9 1.3 1.0 1.3 0.9 1.2
Alcohol intake frequency. 1.7 3.9 9.5 -0.4 0.1 2.1 2.1 3.1 0.9 -2.1 2.3 2.0 1.1 2.0 1.8 1.3 2.0 2.2 1.1 1.7 2.9 1.9 -2.3 -1.7 -2.1 -2.1 -2.2 -2.2 -2.2 -2.3 -2.2 -2.1 -1.6
Comparative height size at age 10 1.6 8.7 33.3 1.2 0.6 -3.4 -3.1 -5.8 -2.0 3.7 -2.4 -3.2 -0.9 -2.7 -2.7 -1.8 -2.6 -3.1 -1.0 -3.0 -4.6 -2.4 3.3 3.6 3.1 3.1 1.6 3.3 2.8 3.1 3.3 3.2 2.2
Number of full sisters 0.2 0.3 0.9 0.5 0.6 0.4 0.3 1.0 0.9 -0.4 0.9 0.3 0.8 0.6 0.4 0.5 0.6 0.6 0.7 0.2 0.3 0.0 -0.4 -0.0 -0.3 -0.3 -0.7 -0.4 -0.6 -0.5 -0.1 -0.3 0.1
Suffer from ‘nerves’ 0.4 0.6 2.2 -0.6 -0.5 0.9 0.9 -0.2 0.4 -0.8 0.8 0.9 -0.1 0.7 0.7 0.6 0.5 0.7 -0.1 0.8 -0.5 0.7 -1.0 -0.1 -0.9 -0.9 -1.3 -0.8 -1.5 -1.0 -0.7 -0.9 -0.8
Overall health rating 0.2 0.4 2.6 0.6 0.7 0.6 0.4 1.6 1.1 0.1 -0.5 0.5 1.0 0.7 -0.3 0.2 0.7 0.7 0.9 0.4 0.5 -0.5 -0.3 -0.9 -0.3 -0.4 0.1 -0.4 0.2 0.0 -0.0 -0.4 0.4
Chest pain or discomfort 0.5 0.7 4.0 1.8 2.0 0.2 0.1 0.2 0.8 0.4 -0.4 0.1 2.0 0.9 -0.4 0.5 1.1 0.7 1.9 0.1 0.8 -0.5 -0.1 0.4 -0.0 -0.1 -0.7 -0.2 0.7 0.3 0.3 -0.1 0.8
Had major operations 1.3 1.6 3.4 0.8 0.5 -1.3 -1.3 -0.8 -0.4 1.6 -1.6 -1.4 -0.2 -1.1 -1.8 -1.0 -0.9 -1.3 -0.1 -1.3 -1.8 -1.2 1.5 1.1 1.3 1.3 1.3 1.4 1.4 1.6 1.2 1.4 1.3
Age at last live birth 1.3 2.0 7.2 2.0 2.4 1.0 1.1 0.2 2.0 -0.7 0.5 1.2 2.7 1.9 1.4 1.4 2.2 1.7 2.7 1.0 1.3 -0.2 -1.1 -0.1 -1.0 -1.1 -1.1 -1.1 -0.4 -0.7 -1.0 -1.0 0.4
Family relationship satisfaction 0.4 0.4 2.5 1.5 1.6 -0.5 -0.4 -0.7 0.2 0.5 -0.1 -0.3 1.3 0.2 -0.0 -0.2 0.4 0.1 1.3 -0.4 0.6 -0.6 0.3 0.8 0.4 0.4 -0.1 0.3 0.6 0.5 0.2 0.4 0.9
Leg pain on walking 0.7 0.9 1.8 1.0 0.8 -1.2 -1.2 0.2 0.3 1.1 -0.5 -1.3 0.2 -0.9 -1.2 -1.4 -0.7 -0.9 0.2 -1.3 0.2 -0.9 1.0 1.1 1.2 1.2 0.3 1.1 0.8 1.0 1.3 1.2 1.1
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.6 -0.7 -0.9 -0.7 -0.7 -0.8 -0.4 0.3 -0.4 -0.8 -1.2 -1.0 -0.8 -0.4 -1.1 -0.9 -1.3 -0.6 -1.1 -0.3 0.7 0.8 0.7 0.7 0.3 0.7 0.1 0.6 0.8 0.6 0.0
Commuting to job workplace: Car/motor vehicle 5.2 6.0 12.0 -2.3 -1.8 2.6 2.6 2.4 -0.0 -3.2 2.9 2.5 -0.4 1.9 2.3 1.6 1.6 2.4 -0.4 2.5 1.6 3.5 -2.9 -2.3 -2.8 -2.6 -2.5 -2.8 -2.6 -2.9 -3.1 -2.8 -3.0
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 1.9 -0.1 -0.4 -1.1 -1.1 -0.9 -1.2 1.2 -1.3 -1.2 -0.8 -1.2 -0.8 -0.4 -1.2 -1.3 -0.8 -1.1 -0.3 -0.7 1.3 0.9 1.1 1.1 1.4 1.3 1.1 1.3 0.9 1.1 0.7
Medication: Aspirin 0.3 0.4 0.8 -0.4 -0.3 0.8 0.8 0.6 0.3 -0.9 0.3 0.7 -0.0 0.6 0.5 0.0 0.5 0.7 -0.0 0.8 0.8 0.5 -0.8 -0.5 -0.7 -0.8 -0.8 -0.7 -0.8 -0.6 -0.3 -0.8 -0.7
Supplements: Vitamin C 1.1 1.3 3.6 -0.3 -0.1 1.3 1.3 1.6 0.4 -1.1 1.5 1.2 0.5 1.2 1.5 0.5 1.1 1.3 0.5 1.0 1.9 1.0 -1.3 -0.9 -1.2 -1.3 -1.1 -1.2 -1.2 -1.3 -1.2 -1.2 -0.9
Knee pain experienced in last month 0.4 0.7 5.3 1.0 1.1 0.5 0.3 1.7 2.3 0.0 -0.5 0.3 1.2 0.7 -0.6 -0.1 0.9 0.6 1.2 0.4 1.0 -0.9 -0.1 -1.0 -0.3 -0.3 0.5 -0.2 0.3 0.2 -0.2 -0.3 0.7
Hypertension (Self-reported) 0.2 0.6 1.2 0.9 0.7 -0.8 -0.9 0.2 0.8 0.7 -0.6 -0.8 0.2 -0.7 -0.8 -1.1 -0.5 -0.6 0.2 -0.9 -0.2 -0.9 0.8 0.5 0.8 0.9 0.6 0.9 0.8 0.8 0.9 0.9 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.3 0.7 0.5 -1.0 -1.0 -0.7 -0.4 1.1 -0.3 -0.9 -0.1 -0.8 -0.9 -0.4 -0.7 -0.9 -0.0 -0.9 -0.6 -0.8 0.9 0.6 0.9 1.0 1.2 1.1 0.8 0.8 0.3 1.0 0.9
Illnesses of father: Heart disease 3.0 4.2 7.3 -1.1 -0.6 2.4 2.4 0.6 0.5 -2.3 2.3 2.5 0.4 2.1 2.7 2.3 1.9 2.3 0.5 2.4 1.7 1.5 -2.3 -2.4 -2.5 -2.4 -1.5 -2.3 -2.3 -2.3 -2.4 -2.4 -2.1
Illnesses of siblings: Diabetes 8.1 10.0 14.8 0.1 1.0 3.5 3.5 2.2 3.1 -3.3 3.7 3.5 2.6 3.8 3.4 3.2 3.8 3.7 2.5 3.6 3.6 1.5 -3.5 -3.0 -3.5 -3.5 -2.6 -3.5 -3.3 -3.4 -3.6 -3.4 -2.1
Smoking status: Previous 0.7 1.1 3.1 1.1 0.9 -1.1 -1.1 0.1 1.0 1.1 -0.9 -1.0 0.4 -0.7 -0.7 -1.1 -0.6 -0.9 0.4 -1.2 -0.6 -1.7 1.2 0.8 1.2 1.1 1.1 1.3 1.3 1.3 1.3 1.2 1.3
Forced expiratory volume in 1-second (FEV1), predicted 5.8 12.1 19.7 2.5 1.7 -3.9 -3.9 -3.7 -1.9 4.1 -3.8 -3.9 -0.1 -3.2 -3.5 -3.2 -2.8 -3.5 -0.2 -4.1 -3.3 -3.1 3.9 3.8 4.1 3.9 2.9 3.9 4.4 4.2 4.4 3.9 3.7
Whole body fat-free mass 0.8 4.4 10.5 1.9 1.5 -2.1 -2.0 -3.2 -0.9 2.8 -2.7 -2.1 0.5 -1.4 -2.7 -1.2 -1.1 -1.7 0.4 -1.9 -2.6 -2.1 2.3 2.6 2.1 2.0 0.9 2.2 2.8 2.6 2.5 2.2 2.2
Leg fat-free mass (right) 0.9 4.7 9.7 1.2 0.8 -2.2 -2.2 -3.1 -1.4 2.8 -2.7 -2.3 -0.3 -1.9 -2.8 -1.8 -1.6 -2.0 -0.3 -2.1 -2.6 -2.0 2.4 2.5 2.2 2.2 1.3 2.3 2.9 2.6 2.7 2.3 1.9
Arm fat percentage (left) 1.6 6.4 21.7 0.2 0.9 2.9 2.8 4.7 3.0 -2.3 2.0 2.8 2.0 2.9 1.9 1.9 3.0 3.0 2.0 2.8 3.3 0.8 -2.7 -2.8 -2.7 -2.8 -1.9 -2.7 -1.9 -2.4 -2.3 -2.7 -1.5
Average weekly red wine intake 0.9 1.3 3.9 0.5 0.2 -1.2 -1.2 -1.0 0.9 1.3 -1.3 -1.2 -0.5 -1.2 -0.9 -0.8 -1.1 -1.3 -0.4 -1.1 -1.0 -2.0 1.3 -0.0 1.1 1.2 2.0 1.4 1.1 1.3 1.0 1.3 1.1
Handedness (chirality/laterality): Left-handed 0.4 0.5 2.0 1.4 1.4 -0.4 -0.4 0.1 -0.5 0.7 -0.3 -0.5 1.3 0.2 -0.2 0.1 0.4 0.1 1.2 -0.5 -1.1 -0.5 0.4 1.1 0.5 0.4 -0.6 0.4 0.6 0.5 0.7 0.5 0.9
Mood swings 0.5 1.0 5.9 -0.7 -0.9 -0.7 -0.7 -0.0 -2.4 0.6 -0.9 -0.8 -1.2 -1.1 -1.3 -1.0 -1.1 -1.0 -1.2 -0.8 -0.4 1.0 0.7 2.0 0.7 0.7 -0.1 0.6 0.5 0.7 0.7 0.6 0.1
Loneliness, isolation 1.2 1.6 6.0 -2.4 -2.3 1.0 1.1 0.3 -1.7 -1.2 0.6 1.1 -1.6 0.3 0.8 0.3 -0.1 0.5 -1.6 1.2 0.1 2.4 -1.1 -0.4 -1.1 -1.1 -1.2 -1.1 -1.2 -1.1 -1.1 -1.3 -2.1
Long-standing illness, disability or infirmity 0.5 0.8 4.0 1.2 1.1 -0.5 -0.5 -0.5 2.0 0.8 -1.1 -0.3 0.8 -0.1 -0.8 -1.6 0.1 -0.3 0.8 -0.5 0.3 -1.8 0.7 -0.4 0.6 0.5 0.7 0.6 1.0 0.9 1.0 0.6 0.8
Ever had bowel cancer screening 0.5 0.6 2.3 -0.1 0.0 0.7 0.8 -0.1 1.5 -0.8 0.7 0.8 0.4 0.8 1.2 1.0 0.7 0.7 0.4 0.7 0.0 -0.1 -0.7 -1.5 -0.8 -0.8 0.3 -0.7 -0.5 -0.7 -1.1 -0.7 -0.6
Diabetes diagnosed by doctor 2.2 3.6 7.8 0.1 0.6 2.1 2.1 0.9 2.6 -1.9 2.0 2.3 1.6 2.3 2.1 1.8 2.3 2.2 1.6 2.0 1.4 0.1 -1.9 -2.8 -2.2 -2.1 -1.2 -2.1 -1.7 -1.9 -2.3 -2.0 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.7 0.4 0.5 0.5 0.4 -0.3 0.5 -0.1 0.8 0.6 0.6 0.6 0.5 0.5 0.6 0.5 0.5 0.3 0.0 -0.3 -0.4 -0.7 -0.6 -0.4 0.1 -0.3 -0.6 -0.5 -0.8 -0.4 0.0
Friendships satisfaction 0.2 0.2 1.3 1.1 1.1 0.0 -0.0 0.6 0.3 0.3 0.3 0.0 1.0 0.3 -0.2 0.5 0.5 0.3 1.0 -0.0 0.4 -0.3 0.1 -0.2 -0.1 0.0 -0.0 0.0 0.4 0.1 -0.4 0.1 0.5
Qualifications: nursing, teaching 1.6 2.5 5.0 0.2 0.7 1.6 1.7 0.5 0.6 -1.4 1.9 1.8 1.5 2.0 2.2 1.4 2.0 1.9 1.5 1.6 1.9 1.3 -1.8 -1.0 -1.7 -1.7 -1.6 -1.7 -1.6 -1.8 -2.0 -1.7 -1.1
Commuting to job workplace: Walk 2.4 2.5 5.1 1.9 1.6 -1.7 -1.8 -0.2 -0.6 2.3 -1.4 -1.7 0.7 -1.2 -1.4 -1.1 -0.9 -1.5 0.7 -1.9 0.1 -2.0 1.8 1.3 1.9 1.8 1.5 1.8 2.0 1.9 2.0 1.9 2.2
Eye problems/disorders: Cataract 2.3 2.7 7.1 2.7 2.4 -1.4 -1.5 0.4 1.4 2.0 -1.7 -1.5 1.4 -0.7 -1.3 -1.2 -0.2 -1.0 1.5 -1.5 0.1 -2.6 1.7 1.0 1.5 1.5 1.8 1.5 2.1 2.0 1.5 1.6 2.5
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 3.6 1.4 1.2 -1.1 -1.0 -1.3 -1.2 1.3 -0.9 -1.0 0.7 -0.5 -1.0 -1.1 -0.3 -0.7 0.7 -1.1 -0.9 -0.3 0.9 1.9 0.9 1.0 -0.1 0.9 1.0 0.9 0.9 1.0 1.2
Medication for cholesterol 1.4 2.1 4.2 0.2 -0.2 -1.8 -1.6 -1.0 -0.8 1.6 -1.2 -1.6 -0.9 -1.6 -1.6 -2.1 -1.6 -1.8 -0.9 -1.9 -1.7 -1.1 1.6 1.7 1.5 1.6 0.8 1.7 1.3 1.4 1.5 1.6 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 1.2 0.4 0.4 0.3 0.2 -0.1 1.0 0.3 -0.2 0.2 0.5 0.4 0.4 1.1 0.4 0.3 0.5 0.3 -0.0 -0.3 -0.1 -0.2 -0.2 -0.2 0.1 -0.1 0.2 0.1 0.1 -0.1 0.3
Back pain experienced in last month 1.4 2.0 6.2 1.3 1.7 1.4 1.3 2.0 2.5 -0.6 0.9 1.3 2.2 1.9 0.6 1.1 2.1 1.8 2.2 1.3 1.4 -0.3 -1.3 -1.6 -1.3 -1.3 -1.0 -1.3 -0.5 -0.9 -1.0 -1.2 -0.2
Mineral and other dietary supplements 0.3 0.4 2.0 0.9 0.9 -0.5 -0.5 0.0 -1.0 0.7 -0.9 -0.5 0.6 -0.2 -1.2 -0.6 -0.1 -0.4 0.6 -0.5 -0.4 -0.2 0.6 1.4 0.4 0.5 -0.1 0.4 0.9 0.7 0.3 0.6 0.9
Breast cancer (self-reported) 0.8 1.0 5.6 -2.0 -2.2 -0.4 -0.4 -0.9 -0.9 0.0 -0.8 -0.5 -2.2 -1.2 -0.5 -0.6 -1.5 -1.0 -2.4 -0.3 -0.3 0.3 0.5 0.3 0.4 0.4 0.6 0.6 0.0 0.3 0.6 0.3 -0.7
Asthma (self-reported) 0.7 1.5 4.9 -0.2 -0.5 -1.3 -1.2 -0.9 -1.0 0.9 -1.8 -1.1 -1.0 -1.3 -1.4 -0.7 -1.4 -1.2 -1.1 -1.0 -2.2 -0.3 1.2 1.9 1.4 1.2 -0.0 1.1 1.3 1.3 1.9 1.1 0.4
Osteoporosis (self-reported) 0.7 0.8 2.5 -0.3 -0.0 1.1 1.1 0.1 0.6 -0.9 0.6 1.2 0.4 1.2 0.9 1.6 1.0 1.0 0.4 1.3 -0.9 0.6 -0.9 -0.3 -1.0 -1.1 -1.2 -1.0 -1.0 -0.9 -0.5 -1.0 -0.8
Osteoarthritis (self-reported) 0.9 1.2 5.9 0.6 0.9 1.2 1.1 1.8 2.4 -0.5 0.5 1.1 1.3 1.3 0.8 0.6 1.4 1.1 1.3 1.0 1.6 -0.3 -0.9 -1.5 -1.0 -1.1 -0.1 -0.8 -0.6 -0.7 -1.0 -0.9 -0.0
Medication: Aspirin 0.4 0.6 1.1 -0.5 -0.3 0.9 0.9 0.7 0.5 -1.0 0.6 0.9 0.0 0.8 0.6 0.2 0.6 0.8 -0.0 0.9 0.8 0.5 -0.9 -0.9 -0.9 -0.9 -0.7 -0.9 -0.9 -0.8 -0.5 -1.0 -0.8
Medication: Gliclazide 0.2 0.2 1.4 0.5 0.4 -0.3 -0.2 0.5 1.2 0.2 -0.0 -0.1 0.2 -0.1 -0.1 -0.7 -0.1 -0.1 0.2 -0.4 0.3 -1.1 0.2 -0.7 0.3 0.2 0.8 0.2 0.5 0.2 0.3 0.2 0.3
Illnesses of father: None of the above (group 1) 2.6 3.3 5.7 2.2 1.9 -1.9 -1.9 1.7 1.4 2.2 -1.8 -1.9 0.9 -1.2 -2.4 -1.6 -0.8 -1.6 0.9 -1.9 -0.2 -2.4 2.0 1.5 1.9 1.9 1.7 2.0 2.3 2.1 1.7 2.1 2.4
Smoking status: Current 0.3 0.5 1.4 0.5 0.3 -0.5 -0.7 0.2 0.5 0.9 -1.1 -0.6 0.0 -0.5 -1.1 -0.8 -0.4 -0.5 0.0 -0.8 -0.1 -1.2 0.7 0.1 0.7 0.7 1.0 0.6 0.6 0.7 0.9 0.7 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 2.0 12.3 -2.8 -2.9 -0.1 -0.0 -1.2 -3.5 -0.5 -1.0 -0.4 -2.8 -1.1 -0.3 0.1 -1.5 -0.8 -2.7 0.1 -0.7 2.2 0.2 1.0 0.0 0.0 -0.6 -0.0 -0.2 0.0 0.3 -0.1 -1.5
Whole body water mass 0.7 4.1 9.7 1.9 1.5 -2.0 -1.9 -3.1 -0.9 2.8 -2.5 -2.0 0.6 -1.3 -2.6 -1.1 -1.0 -1.6 0.5 -1.8 -2.5 -2.0 2.2 2.5 2.0 1.9 0.8 2.1 2.7 2.5 2.5 2.1 2.1
Leg predicted mass (right) 0.8 4.5 9.8 1.2 0.7 -2.2 -2.1 -3.1 -1.4 2.7 -2.6 -2.2 -0.3 -1.8 -2.7 -1.8 -1.6 -2.0 -0.3 -2.1 -2.5 -1.9 2.4 2.4 2.2 2.1 1.2 2.3 2.8 2.6 2.7 2.2 1.9
Arm fat mass (left) 0.8 3.4 7.9 0.6 1.1 2.2 2.1 2.8 2.5 -1.4 1.3 2.1 1.9 2.4 1.2 1.5 2.5 2.4 1.9 2.1 2.1 0.2 -1.9 -2.0 -2.0 -2.1 -1.6 -1.9 -1.2 -1.5 -1.5 -2.0 -0.9
Number of self-reported non-cancer illnesses 0.1 0.2 1.4 0.4 0.3 -0.3 -0.3 0.4 1.2 0.3 -0.9 -0.1 0.0 -0.2 -0.5 -0.4 -0.2 -0.2 0.0 -0.2 -0.5 -1.0 0.4 -0.5 0.4 0.3 0.5 0.3 0.7 0.6 0.8 0.3 0.4
Average weekly champagne plus white wine intake 1.0 1.3 3.2 -1.5 -1.3 1.0 1.2 -1.1 -0.9 -1.3 1.4 1.2 -0.7 0.7 1.7 1.1 0.4 0.8 -0.7 1.3 0.1 1.6 -1.0 -0.2 -1.2 -1.2 -1.4 -1.1 -1.2 -1.1 -1.3 -1.1 -1.8
Miserableness 0.2 0.3 1.2 -1.1 -1.0 0.4 0.4 0.2 -0.4 -0.6 -0.1 0.4 -0.7 0.1 0.3 0.1 -0.1 0.4 -0.7 0.5 -0.6 1.0 -0.5 0.4 -0.4 -0.4 -0.8 -0.6 -0.7 -0.5 -0.3 -0.6 -0.8
Guilty feelings 0.3 0.5 0.9 -0.3 -0.1 0.8 0.7 0.9 0.7 -0.6 0.9 0.7 0.3 0.7 1.0 0.6 0.6 0.7 0.2 0.7 -0.2 0.6 -0.8 -0.6 -0.8 -0.7 -0.6 -0.8 -0.8 -0.8 -0.9 -0.8 -0.6
Wears glasses or contact lenses 0.1 0.2 1.7 -0.6 -0.6 0.2 0.2 -0.3 -1.3 -0.4 0.4 0.2 -0.4 0.1 0.3 -0.5 -0.1 -0.0 -0.4 0.3 -0.5 0.2 -0.1 -0.1 -0.1 -0.2 -0.4 -0.1 -0.3 -0.2 0.3 -0.2 -0.7
Ever taken oral contraceptive pill 1.1 1.2 3.7 1.1 0.8 -1.2 -1.3 -0.0 -0.6 1.2 -1.4 -1.3 0.2 -1.0 -1.0 -1.0 -0.8 -1.0 0.2 -1.3 -0.6 -0.5 1.3 1.9 1.3 1.3 0.4 1.1 1.4 1.3 1.5 1.3 1.4
Hearing aid user 1.7 2.0 3.6 0.3 0.8 1.7 1.6 0.4 0.7 -1.2 1.0 1.6 1.4 1.8 1.6 1.1 1.9 1.7 1.4 1.5 1.9 1.3 -1.5 -1.2 -1.6 -1.6 -1.6 -1.6 -0.7 -1.2 -1.5 -1.6 -1.0
Mother’s age at death 1.1 1.4 3.8 -0.8 -1.1 -1.2 -1.0 -1.3 -0.3 0.9 -1.3 -1.1 -1.6 -1.4 -0.8 -1.6 -1.5 -1.5 -1.5 -1.2 -2.0 -0.7 1.3 0.9 1.1 1.0 1.2 1.1 0.8 1.1 1.3 1.0 0.3
Financial situation satisfaction 0.8 1.0 3.5 -1.2 -1.5 -0.9 -0.9 -1.6 -1.9 0.5 0.1 -0.9 -1.7 -1.3 -0.9 -0.7 -1.5 -1.0 -1.8 -0.8 -0.9 0.7 0.7 0.6 0.8 0.9 0.2 0.7 0.2 0.3 0.7 0.7 -0.5
Tinnitus: Yes, now most or all of the time 1.2 1.4 5.3 -1.1 -0.9 1.1 1.1 0.1 -1.1 -1.5 1.6 1.1 -0.4 0.8 1.5 1.2 0.6 1.0 -0.3 1.2 1.3 2.3 -1.2 -0.1 -1.1 -1.1 -1.8 -1.2 -1.3 -1.4 -1.1 -1.2 -1.6
Commuting to job workplace: Public transport 0.6 0.7 3.5 1.4 1.4 -0.1 -0.2 -1.1 1.9 0.5 -0.9 -0.1 1.2 0.2 -0.0 0.4 0.4 0.0 1.1 -0.1 0.8 -1.9 0.3 -0.7 0.3 0.2 1.1 0.3 0.4 0.5 0.3 0.4 1.2
Eye problems/disorders: Glaucoma 0.5 0.6 1.6 1.2 1.2 -0.8 -0.7 -0.2 0.2 0.9 -1.1 -0.7 0.8 -0.2 -0.8 -0.6 -0.0 -0.5 0.8 -0.5 0.0 -0.7 0.8 1.1 0.7 0.7 0.3 0.7 1.1 1.0 0.5 0.8 0.9
Medication: Blood pressure 0.1 0.2 1.8 0.1 0.2 0.4 0.2 0.8 1.3 -0.2 0.3 0.2 0.2 0.2 0.4 0.3 0.2 0.3 0.2 0.4 1.3 -0.3 -0.2 -1.2 -0.1 -0.2 0.8 -0.1 -0.2 -0.1 -0.1 -0.2 0.2
Pain type(s) experienced in last month: Hip pain 1.3 1.7 2.6 -0.5 -0.1 1.6 1.6 0.9 0.1 -1.3 1.3 1.5 0.6 1.4 1.3 1.3 1.4 1.6 0.6 1.4 1.4 1.6 -1.6 -0.9 -1.4 -1.6 -1.6 -1.6 -1.3 -1.5 -1.2 -1.6 -1.2
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.8 -0.3 -0.4 -0.5 -0.6 -0.2 -0.4 0.4 -0.1 -0.7 -0.6 -0.7 -0.0 0.0 -0.7 -0.6 -0.7 -0.6 0.0 0.1 0.5 0.4 0.6 0.6 0.2 0.6 0.3 0.4 0.9 0.5 0.2
High cholesterol (Self-reported) 1.6 2.8 4.8 0.9 1.3 1.7 1.6 1.7 1.6 -1.7 1.8 1.9 1.9 2.1 1.9 1.3 2.2 2.1 2.0 1.5 1.9 1.3 -1.7 -1.2 -1.8 -1.6 -1.9 -1.6 -1.3 -1.5 -1.9 -1.6 -0.8
Medication: Bendroflumethiazide 0.2 0.3 1.4 1.2 1.2 -0.2 -0.3 0.7 0.4 0.4 -0.2 -0.3 0.9 0.1 -0.4 -0.4 0.3 -0.1 0.9 -0.1 0.6 -0.6 0.4 0.3 0.3 0.3 0.4 0.3 0.4 0.4 0.1 0.4 1.0
Medication: Paracetamol 1.0 1.6 3.7 1.0 0.8 -1.4 -1.3 -1.0 -0.4 1.4 -1.7 -1.5 0.1 -1.0 -1.7 -1.2 -0.8 -1.1 0.1 -1.3 -1.6 -0.9 1.5 1.9 1.3 1.3 0.6 1.4 1.5 1.6 1.2 1.4 1.4
Medication: Lisinopril 0.8 1.0 2.6 0.5 0.2 -1.1 -1.1 -0.4 -0.0 1.3 -1.0 -1.0 -0.4 -1.1 -1.1 -1.1 -0.9 -1.1 -0.3 -1.0 -1.5 -1.3 1.2 0.1 1.0 1.1 1.6 1.1 1.2 1.1 0.8 1.2 1.0
Medication: Atorvastatin 1.7 2.1 4.7 -0.9 -0.5 1.6 1.7 1.3 1.9 -1.7 1.4 1.8 0.3 1.5 1.7 0.9 1.3 1.5 0.3 1.6 1.5 0.6 -1.6 -2.2 -1.7 -1.7 -0.8 -1.6 -1.4 -1.5 -1.9 -1.7 -1.5
Illnesses of father: High blood pressure 2.6 3.3 16.1 -1.8 -2.3 -1.4 -1.3 -4.0 -2.8 0.8 -1.0 -1.5 -2.8 -2.2 -1.0 -1.7 -2.4 -1.8 -2.8 -1.3 -2.8 0.3 1.3 1.2 1.4 1.4 1.2 1.2 0.7 1.0 1.6 1.1 -0.1
Alcohol drinker status: Never 0.8 0.9 4.0 0.6 0.8 0.7 0.7 0.7 1.3 -0.8 1.8 0.8 1.1 1.0 1.1 0.3 1.1 1.0 1.1 0.5 2.0 0.4 -1.0 -1.0 -0.8 -0.7 -0.9 -0.8 -1.1 -1.0 -1.1 -0.7 -0.3
Ever smoked 0.4 0.6 2.6 1.3 1.3 -0.3 -0.4 -0.1 1.3 0.9 -0.8 -0.3 0.9 0.0 -0.7 -0.3 0.2 -0.3 1.0 -0.5 -0.8 -1.6 0.6 0.3 0.5 0.4 0.7 0.6 0.9 0.8 0.8 0.6 1.1
Basal metabolic rate 0.5 2.9 5.8 1.8 1.5 -1.6 -1.6 -2.4 -0.5 2.4 -2.2 -1.7 0.7 -1.0 -2.2 -0.9 -0.7 -1.2 0.6 -1.5 -2.0 -1.8 1.9 2.1 1.6 1.6 0.6 1.8 2.4 2.2 2.1 1.7 1.9
Leg fat percentage (left) 3.2 11.4 29.6 -0.3 0.6 4.0 3.8 5.4 3.3 -3.5 3.6 3.8 2.2 3.9 3.0 2.2 3.8 4.0 2.2 3.8 4.0 1.8 -3.7 -3.8 -3.7 -3.8 -2.9 -3.6 -3.1 -3.5 -3.3 -3.7 -2.6
Arm fat-free mass (left) 0.2 1.1 4.3 1.2 1.2 -0.7 -0.7 -2.1 -0.2 1.5 -1.3 -0.8 0.8 -0.2 -1.5 -0.3 -0.0 -0.4 0.8 -0.5 -1.4 -1.1 1.0 1.4 0.7 0.7 -0.2 0.9 1.5 1.3 1.3 0.8 1.1
Number of operations (self-reported) 1.2 1.8 5.2 1.2 1.0 -1.3 -1.4 0.0 1.3 1.8 -1.8 -1.3 0.2 -1.1 -1.9 -0.9 -0.8 -1.2 0.3 -1.3 -1.1 -2.3 1.5 0.0 1.4 1.4 2.1 1.4 1.3 1.6 1.2 1.4 1.8
Average weekly beer plus cider intake 0.4 0.5 2.1 0.1 0.3 0.9 0.9 0.8 -0.0 -0.6 0.1 0.8 0.7 1.0 0.3 1.4 1.0 0.9 0.7 0.9 0.2 0.7 -0.7 -0.3 -0.9 -0.9 -0.9 -0.8 -0.4 -0.5 -0.7 -0.8 -0.4
Irritability 0.5 0.8 2.9 1.3 1.3 -0.8 -0.8 0.4 0.2 1.0 -1.7 -0.9 0.8 -0.4 -1.1 -0.7 -0.1 -0.5 0.8 -0.9 -0.3 -1.2 0.8 0.9 0.8 0.8 0.7 0.6 1.2 1.0 0.7 0.8 1.4
Risk taking 3.0 4.4 7.7 -0.9 -0.4 2.4 2.4 1.4 -0.2 -2.4 2.2 2.5 0.8 2.2 2.0 2.0 2.0 2.4 0.7 2.3 1.7 2.8 -2.4 -1.5 -2.4 -2.4 -2.6 -2.4 -1.9 -2.4 -2.5 -2.4 -2.2
Ever had prostate specific antigen (PSA) test 1.0 1.2 5.2 -2.3 -2.3 0.5 0.6 -1.6 -0.4 -0.9 1.2 0.6 -1.9 -0.2 1.1 -0.4 -0.6 -0.0 -1.9 0.5 -1.0 1.0 -0.4 -1.3 -0.8 -0.6 0.3 -0.3 -0.9 -0.7 -1.2 -0.6 -1.6
Fractured/broken bones in last 5 years 0.2 0.2 0.7 -0.2 -0.1 0.5 0.6 0.6 0.6 -0.6 0.2 0.6 0.2 0.6 0.3 0.7 0.4 0.4 0.1 0.8 -0.9 0.1 -0.5 -0.2 -0.5 -0.6 -0.7 -0.5 -0.4 -0.5 -0.1 -0.5 -0.5
Age started oral contraceptive pill 0.5 0.6 2.2 0.1 0.3 0.7 0.8 0.4 1.5 -1.1 0.1 0.9 0.7 1.0 0.8 1.3 0.9 0.9 0.7 0.9 0.5 0.3 -0.6 -0.1 -0.7 -0.8 -0.7 -0.8 -0.6 -0.4 -0.7 -0.8 -0.4
Diastolic blood pressure, automated reading 0.1 0.3 2.8 0.2 0.2 -0.1 -0.2 0.3 -1.7 0.5 -0.7 -0.4 0.1 -0.2 -0.7 -0.2 -0.1 -0.1 0.1 -0.1 -0.9 0.8 0.3 1.0 0.3 0.2 -0.2 0.2 0.6 0.4 0.3 0.2 0.4
Ever depressed for a whole week 0.2 0.3 0.9 -0.6 -0.5 0.5 0.5 -0.7 -0.6 -0.6 0.9 0.4 -0.3 0.3 0.6 -0.1 0.2 0.3 -0.3 0.5 -0.5 0.8 -0.4 -0.3 -0.5 -0.5 -0.4 -0.5 -0.6 -0.5 -0.6 -0.4 -0.8
Unable to work because of sickness or disability 1.4 1.8 5.7 -1.7 -1.4 1.6 1.5 0.6 1.0 -1.6 1.3 1.6 -0.6 1.0 0.8 0.7 0.7 1.2 -0.6 1.4 0.6 1.0 -1.6 -2.4 -1.6 -1.5 -0.8 -1.5 -1.8 -1.6 -1.5 -1.6 -1.7
Commuting to job workplace: Cycle 3.9 4.7 8.1 0.7 0.1 -2.6 -2.4 -2.1 -0.7 2.4 -2.7 -2.4 -1.1 -2.3 -2.3 -1.5 -2.2 -2.5 -1.0 -2.3 -2.3 -2.0 2.5 2.5 2.5 2.4 1.7 2.6 2.4 2.5 2.8 2.4 1.8
Myopia 0.8 1.2 3.7 -0.2 0.0 1.1 1.2 1.2 1.3 -1.5 1.6 1.3 0.5 1.1 1.2 1.0 1.0 1.1 0.5 1.1 0.5 -0.2 -1.2 -1.9 -1.1 -1.2 -0.6 -1.1 -1.4 -1.3 -0.9 -1.1 -1.1
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.9 -1.1 -1.3 -0.6 -0.4 -1.4 -1.4 0.3 -0.3 -0.5 -1.3 -0.8 -0.2 -0.0 -1.0 -0.8 -1.3 -0.5 -1.2 0.2 0.4 0.4 0.5 0.4 0.5 0.4 0.2 0.3 0.3 0.3 -0.4
Cholesterol lowering medication 2.2 3.2 5.1 -0.4 0.0 2.2 2.1 0.8 0.3 -2.0 2.2 2.1 0.9 2.0 2.2 1.9 1.9 2.0 1.0 2.2 1.4 2.0 -2.0 -1.3 -2.0 -2.1 -1.9 -1.9 -2.1 -2.0 -1.9 -1.9 -1.5
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.6 -0.6 -0.5 0.7 0.7 0.0 0.0 -0.7 0.9 0.8 -0.3 0.5 1.3 0.2 0.4 0.6 -0.2 0.8 0.1 0.8 -0.7 -0.5 -0.8 -0.7 -0.5 -0.7 -0.6 -0.7 -0.7 -0.7 -0.9
Pain experienced in last month 0.4 0.6 2.1 -0.9 -0.8 0.5 0.6 0.1 -1.2 -1.0 1.3 0.6 -0.4 0.4 1.5 0.6 0.2 0.4 -0.4 0.5 -0.5 1.4 -0.8 -0.4 -0.6 -0.6 -0.8 -0.8 -0.8 -1.0 -0.8 -0.7 -1.1
Supplements: Calcium 1.9 2.1 6.1 -0.6 -0.3 1.4 1.6 -0.2 2.3 -1.8 1.6 1.8 0.5 1.5 1.9 1.1 1.3 1.7 0.4 1.5 0.4 0.3 -1.7 -2.5 -1.4 -1.6 -0.5 -1.6 -1.6 -1.7 -1.5 -1.6 -1.4
Basal cell carcinoma (self-reported) 1.0 1.1 2.4 1.0 0.8 -1.2 -1.2 -0.6 0.2 1.3 -1.4 -1.1 0.1 -0.9 -1.1 -0.8 -0.7 -1.1 0.2 -1.1 -1.5 -1.2 1.2 0.7 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.2 1.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 2.0 1.3 1.4 -0.0 -0.0 0.3 0.9 0.3 -0.1 0.0 1.3 0.5 -0.1 0.3 0.7 0.3 1.3 0.0 0.2 -0.7 0.1 0.1 0.1 0.0 -0.5 0.1 0.5 0.3 0.5 0.1 0.6
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.1 -0.3 -0.0 1.0 0.9 0.3 -0.1 -0.9 0.4 0.8 0.4 0.9 0.3 0.6 0.8 0.9 0.4 0.8 0.6 1.0 -0.8 -0.2 -0.8 -0.9 -0.8 -0.9 -0.7 -0.7 -0.7 -0.9 -0.5
Heart disease (siblings) 2.3 2.8 5.0 0.2 0.6 2.0 1.9 1.2 0.7 -1.6 2.2 1.9 1.4 2.1 2.0 1.7 2.0 1.9 1.4 1.8 2.1 1.5 -1.8 -0.8 -1.9 -1.9 -2.0 -1.7 -1.8 -1.8 -1.7 -1.7 -1.3
Alcohol drinker status: Previous 0.2 0.2 1.3 -0.9 -0.9 0.1 0.1 -0.1 1.1 -0.3 -0.3 -0.0 -0.7 -0.3 -0.3 -0.5 -0.3 -0.1 -0.7 -0.0 0.5 -0.2 -0.1 -0.6 -0.0 -0.1 0.4 -0.2 -0.2 -0.0 0.2 -0.2 -0.1
Pack years of smoking 0.7 1.1 6.1 -2.4 -2.5 0.3 0.3 -0.2 -1.3 -0.7 -0.0 0.3 -2.2 -0.6 0.1 -1.2 -1.0 -0.3 -2.2 0.2 0.3 1.1 -0.4 -0.3 -0.4 -0.3 -0.1 -0.4 -1.0 -0.7 -0.3 -0.5 -1.2
Impedance of whole body 0.5 2.5 6.1 2.4 2.1 -1.7 -1.7 0.6 0.6 1.8 -1.6 -1.7 1.1 -0.9 -0.8 -1.3 -0.6 -1.3 1.1 -1.7 -0.3 -1.9 1.7 1.4 1.8 1.7 2.1 1.7 2.0 1.9 1.2 1.8 2.5
Leg fat mass (left) 1.1 4.4 10.0 -0.1 0.5 2.6 2.4 3.2 1.9 -2.0 2.0 2.4 1.5 2.5 1.6 1.5 2.5 2.6 1.5 2.4 2.3 1.1 -2.3 -2.1 -2.3 -2.4 -2.1 -2.3 -1.7 -2.1 -1.8 -2.4 -1.6
Arm predicted mass (left) 0.2 0.9 4.0 1.3 1.2 -0.6 -0.6 -2.0 -0.1 1.3 -1.1 -0.7 1.0 -0.1 -1.3 -0.3 0.1 -0.2 0.9 -0.4 -1.3 -1.0 0.8 1.2 0.6 0.6 -0.2 0.8 1.3 1.1 1.1 0.7 1.0