Best TWAS P=1.83e-43 · Best GWAS P=2.89e-83 conditioned to 2.56e-38
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SSR1 | 0.20 | 0.03 | bslmm | 635 | 0.14 | 2.3e-16 | -1.1 | -5.3 | 9.0e-08 | -0.01 | 0.92 | 0.00 | TRUE |
| 2 | GTEx | Stomach | RIOK1 | 0.23 | 0.06 | enet | 28 | 0.07 | 2.6e-04 | -1.3 | 7.1 | 1.3e-12 | 0.22 | 0.44 | 0.11 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TXNDC5 | 0.05 | 0.03 | lasso | 5 | 0.03 | 1.6e-06 | -5.9 | 5.3 | 1.1e-07 | -0.09 | 0.02 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TXNDC5 | 0.07 | 0.05 | lasso | 3 | 0.05 | 2.1e-06 | -5.9 | 5.9 | 3.2e-09 | -0.05 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | TXNDC5 | 0.12 | 0.06 | enet | 8 | 0.06 | 1.8e-07 | -5.1 | 5.4 | 7.3e-08 | -0.05 | 0.05 | 0.95 | FALSE |
| 6 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | BMP6 | 0.29 | 0.00 | blup | 162 | 0.03 | 5.6e-02 | 3.2 | 13.8 | 1.8e-43 | 0.49 | 0.02 | 0.20 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | TXNDC5 | 0.08 | 0.06 | lasso | 2 | 0.05 | 1.1e-05 | -5.9 | 5.7 | 1.2e-08 | -0.05 | 0.03 | 0.97 | FALSE |