Best TWAS P=1.99e-16 · Best GWAS P=1.12e-20 conditioned to 0.0666
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AFF3 | 0.31 | 0.24 | enet | 32 | 0.25 | 9.2e-31 | 6.2 | 6.5 | 5.9e-11 | 0.59 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | CHST10 | 0.05 | 0.02 | blup | 474 | 0.04 | 1.0e-05 | -6.8 | 6.9 | 5.0e-12 | 0.59 | 0.62 | 0.36 | FALSE |
| 3 | GTEx | Adrenal Gland | CHST10 | 0.18 | 0.04 | lasso | 4 | 0.05 | 5.6e-03 | 6.4 | -7.7 | 1.4e-14 | -0.70 | 0.30 | 0.23 | FALSE |
| 4 | GTEx | Artery Aorta | AFF3 | 0.14 | 0.06 | lasso | 5 | 0.07 | 1.2e-04 | 9.1 | 8.1 | 7.2e-16 | 0.84 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Artery Tibial | AFF3 | 0.06 | 0.04 | enet | 6 | 0.04 | 4.3e-04 | -7.5 | 7.5 | 5.6e-14 | 0.73 | 0.11 | 0.85 | FALSE |
| 6 | GTEx | Cells EBV-transformed lymphocytes | CHST10 | 0.25 | 0.15 | lasso | 4 | 0.12 | 9.1e-05 | -7.6 | 7.1 | 1.2e-12 | 0.62 | 0.34 | 0.15 | FALSE |
| 7 | GTEx | Muscle Skeletal | LONRF2 | 0.07 | 0.08 | lasso | 4 | 0.08 | 2.5e-08 | 6.6 | 6.6 | 3.0e-11 | 0.53 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | LONRF2 | 0.05 | 0.03 | lasso | 2 | 0.02 | 9.3e-03 | -7.1 | 7.4 | 1.9e-13 | 0.55 | 0.33 | 0.09 | FALSE |
| 9 | GTEx | Thyroid | CHST10 | 0.05 | 0.05 | lasso | 5 | 0.03 | 2.6e-03 | 6.4 | 6.9 | 4.0e-12 | 0.59 | 0.37 | 0.44 | FALSE |
| 10 | METSIM | Adipose | LONRF2 | 0.04 | 0.01 | bslmm | 445 | 0.02 | 1.9e-03 | 6.6 | 5.5 | 4.2e-08 | 0.46 | 0.59 | 0.12 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | AFF3 | 0.31 | 0.24 | enet | 38 | 0.25 | 3.5e-32 | 6.1 | 5.8 | 5.6e-09 | 0.51 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LONRF2 | 0.06 | 0.04 | blup | 69 | 0.04 | 3.4e-05 | -6.9 | 8.2 | 2.0e-16 | 0.67 | 0.30 | 0.69 | TRUE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LONRF2 | 0.05 | 0.08 | lasso | 2 | 0.08 | 2.9e-05 | -7.4 | 7.3 | 2.1e-13 | 0.65 | 0.15 | 0.42 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AFF3 | 0.03 | 0.01 | blup | 240 | 0.02 | 6.6e-03 | 4.5 | 5.4 | 5.6e-08 | 0.36 | 0.11 | 0.53 | TRUE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CHST10 | 0.04 | 0.03 | blup | 73 | 0.02 | 1.5e-03 | -6.9 | 5.4 | 5.4e-08 | 0.47 | 0.01 | 0.96 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AFF3 | 0.06 | 0.00 | blup | 244 | 0.01 | 1.3e-02 | -4.4 | 8.1 | 5.5e-16 | 0.53 | 0.09 | 0.08 | TRUE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | CHST10 | 0.04 | 0.04 | lasso | 3 | 0.03 | 2.6e-04 | 6.4 | 6.4 | 1.6e-10 | 0.52 | 0.04 | 0.94 | FALSE |