Best TWAS P=8.67e-09 · Best GWAS P=7.45e-08 conditioned to 0.877
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | KIFC2 | 0.05 | 0.06 | enet | 6 | 0.06 | 4.4e-08 | -5.1 | -5.3 | 1.4e-07 | 0.94 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CTD-2517M22.16 | 0.12 | 0.05 | lasso | 3 | 0.06 | 3.3e-05 | -5.3 | 5.5 | 3.5e-08 | -0.96 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Esophagus Muscularis | KIFC2 | 0.16 | 0.15 | lasso | 3 | 0.13 | 3.4e-08 | -5.4 | -5.4 | 7.9e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Heart Left Ventricle | KIFC2 | 0.09 | 0.05 | lasso | 3 | 0.03 | 1.2e-02 | -5.4 | -5.2 | 2.5e-07 | 0.97 | 0.01 | 0.94 | FALSE |
| 5 | GTEx | Pancreas | KIFC2 | 0.20 | 0.14 | enet | 4 | 0.08 | 3.7e-04 | -5.3 | -5.4 | 8.6e-08 | 0.95 | 0.01 | 0.96 | FALSE |
| 6 | GTEx | Testis | KIFC2 | 0.15 | 0.11 | lasso | 3 | 0.07 | 3.7e-04 | -5.3 | -5.2 | 1.9e-07 | 0.97 | 0.01 | 0.98 | FALSE |
| 7 | GTEx | Thyroid | CYHR1 | 0.08 | 0.10 | enet | 5 | 0.04 | 3.6e-04 | -5.4 | -5.3 | 9.7e-08 | 0.99 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Whole Blood | PPP1R16A | 0.12 | 0.10 | enet | 9 | 0.08 | 7.3e-08 | -5.3 | 5.2 | 2.0e-07 | -0.96 | 0.01 | 0.99 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | CYHR1 | 0.09 | 0.08 | enet | 10 | 0.10 | 5.9e-13 | -5.1 | -5.1 | 3.0e-07 | 0.91 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | KIFC2 | 0.06 | 0.04 | lasso | 5 | 0.01 | 1.1e-01 | -5.3 | -5.3 | 1.4e-07 | 0.98 | 0.01 | 0.86 | FALSE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CYHR1 | 0.03 | 0.01 | lasso | 4 | 0.01 | 1.7e-02 | -5.3 | 5.8 | 8.7e-09 | -0.94 | 0.01 | 0.79 | TRUE |