Best TWAS P=1.75e-11 · Best GWAS P=8.92e-09 conditioned to 0.0308
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | THEM6 | 0.11 | 0.03 | enet | 18 | 0.06 | 2.8e-04 | 4.7 | 6.7 | 1.8e-11 | 0.60 | 0.15 | 0.50 | TRUE |
| 2 | GTEx | Artery Coronary | LY6K | 0.19 | 0.12 | lasso | 7 | 0.16 | 6.0e-06 | 4.6 | 5.2 | 2.1e-07 | 0.81 | 0.06 | 0.94 | FALSE |
| 3 | GTEx | Brain Cerebellum | LY6K | 0.36 | 0.31 | lasso | 10 | 0.36 | 1.8e-11 | -4.6 | 5.1 | 2.6e-07 | 0.83 | 0.22 | 0.78 | FALSE |
| 4 | GTEx | Brain Hippocampus | LY6K | 0.20 | 0.06 | enet | 16 | 0.11 | 1.6e-03 | -3.7 | 5.3 | 1.3e-07 | 0.73 | 0.13 | 0.46 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | JRK | 0.13 | 0.04 | lasso | 5 | 0.05 | 1.5e-04 | 5.8 | -5.7 | 1.5e-08 | -0.89 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Esophagus Gastroesophageal Junction | LY6K | 0.28 | 0.07 | lasso | 9 | 0.12 | 6.0e-05 | 4.6 | 5.7 | 1.3e-08 | 0.73 | 0.03 | 0.88 | FALSE |
| 7 | GTEx | Esophagus Mucosa | LY6K | 0.25 | 0.20 | lasso | 7 | 0.22 | 1.4e-14 | 5.8 | 5.7 | 1.5e-08 | 0.96 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Esophagus Mucosa | CTD-2292P10.2 | 0.11 | 0.04 | lasso | 10 | 0.04 | 1.5e-03 | 5.5 | 5.7 | 1.2e-08 | 0.79 | 0.02 | 0.95 | FALSE |
| 9 | GTEx | Nerve Tibial | THEM6 | 0.12 | 0.07 | enet | 10 | 0.06 | 5.1e-05 | -4.6 | 5.4 | 5.9e-08 | 0.86 | 0.03 | 0.96 | FALSE |
| 10 | GTEx | Stomach | JRK | 0.26 | 0.20 | enet | 10 | 0.25 | 3.7e-12 | 5.8 | 5.5 | 4.9e-08 | 0.95 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Testis | BAI1 | 0.18 | 0.13 | enet | 11 | 0.15 | 3.2e-07 | 4.0 | -5.8 | 8.5e-09 | -0.30 | 0.56 | 0.40 | FALSE |
| 12 | GTEx | Thyroid | CTD-2292P10.2 | 0.12 | 0.10 | lasso | 4 | 0.08 | 4.7e-07 | 5.5 | 5.7 | 9.0e-09 | 0.95 | 0.02 | 0.98 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LY6K | 0.05 | 0.04 | lasso | 4 | 0.06 | 1.7e-12 | -4.7 | 5.2 | 2.4e-07 | 0.84 | 0.00 | 0.97 | FALSE |
| 14 | The Cancer Genome Atlas | Glioblastoma Multiforme | LY6K | 0.12 | 0.08 | enet | 5 | 0.12 | 1.3e-04 | -4.7 | 5.1 | 2.9e-07 | 0.85 | 0.00 | 0.40 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LY6K | 0.11 | 0.09 | enet | 6 | 0.09 | 8.2e-06 | -4.7 | 5.2 | 2.3e-07 | 0.85 | 0.00 | 0.92 | FALSE |
| 16 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LY6K | 0.07 | 0.03 | enet | 8 | 0.03 | 4.0e-03 | -4.7 | 5.2 | 1.8e-07 | 0.89 | 0.00 | 0.16 | FALSE |
| 17 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LY6K | 0.09 | 0.04 | lasso | 5 | 0.07 | 7.0e-04 | -4.7 | 5.1 | 2.6e-07 | 0.85 | 0.00 | 0.70 | FALSE |