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chr10:68,946,505-70,532,990

Best TWAS P=8.91e-10 · Best GWAS P=2.18e-09 conditioned to 0.00819

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Heart Left Ventricle	HERC4	0.09	0.06	enet	10	0.07	1.3e-04	-3.6	-6.1	8.9e-10	0.65	0.11	0.70	TRUE
6	The Cancer Genome Atlas	Lung Adenocarcinoma	HERC4	0.03	0.02	blup	77	0.01	6.7e-03	-5.9	-6.0	2.4e-09	0.98	0.02	0.94	FALSE
8	The Cancer Genome Atlas	Thyroid Carcinoma	HERC4	0.04	0.02	lasso	4	0.03	3.1e-04	-5.8	-5.9	3.2e-09	0.89	0.03	0.95	FALSE
3	YFS	Blood	SIRT1	0.10	0.20	lasso	5	0.20	1.4e-63	-5.6	-5.7	1.1e-08	0.96	0.11	0.89	FALSE
2	GTEx	Whole Blood	SIRT1	0.07	0.07	enet	7	0.06	1.3e-06	-5.6	-5.7	1.4e-08	0.97	0.08	0.92	FALSE
9	The Cancer Genome Atlas	Thyroid Carcinoma	SIRT1	0.04	0.05	lasso	1	0.04	2.0e-04	-5.6	-5.6	1.7e-08	0.94	0.02	0.97	FALSE
4	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SIRT1	0.02	0.02	blup	42	0.01	6.3e-02	-5.6	-5.5	4.6e-08	0.95	0.03	0.67	FALSE
7	The Cancer Genome Atlas	Prostate Adenocarcinoma	SIRT1	0.05	0.06	enet	8	0.06	1.7e-06	-5.6	-5.2	1.6e-07	0.94	0.04	0.96	FALSE
5	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SIRT1	0.03	0.02	blup	42	0.03	3.2e-04	-5.6	-5.1	3.1e-07	0.88	0.02	0.89	FALSE