Best TWAS P=8.91e-10 · Best GWAS P=2.18e-09 conditioned to 0.00819
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Left Ventricle | HERC4 | 0.09 | 0.06 | enet | 10 | 0.07 | 1.3e-04 | -3.6 | -6.1 | 8.9e-10 | 0.65 | 0.11 | 0.70 | TRUE |
| 2 | GTEx | Whole Blood | SIRT1 | 0.07 | 0.07 | enet | 7 | 0.06 | 1.3e-06 | -5.6 | -5.7 | 1.4e-08 | 0.97 | 0.08 | 0.92 | FALSE |
| 3 | YFS | Blood | SIRT1 | 0.10 | 0.20 | lasso | 5 | 0.20 | 1.4e-63 | -5.6 | -5.7 | 1.1e-08 | 0.96 | 0.11 | 0.89 | FALSE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SIRT1 | 0.02 | 0.02 | blup | 42 | 0.01 | 6.3e-02 | -5.6 | -5.5 | 4.6e-08 | 0.95 | 0.03 | 0.67 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SIRT1 | 0.03 | 0.02 | blup | 42 | 0.03 | 3.2e-04 | -5.6 | -5.1 | 3.1e-07 | 0.88 | 0.02 | 0.89 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | HERC4 | 0.03 | 0.02 | blup | 77 | 0.01 | 6.7e-03 | -5.9 | -6.0 | 2.4e-09 | 0.98 | 0.02 | 0.94 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SIRT1 | 0.05 | 0.06 | enet | 8 | 0.06 | 1.7e-06 | -5.6 | -5.2 | 1.6e-07 | 0.94 | 0.04 | 0.96 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | HERC4 | 0.04 | 0.02 | lasso | 4 | 0.03 | 3.1e-04 | -5.8 | -5.9 | 3.2e-09 | 0.89 | 0.03 | 0.95 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | SIRT1 | 0.04 | 0.05 | lasso | 1 | 0.04 | 2.0e-04 | -5.6 | -5.6 | 1.7e-08 | 0.94 | 0.02 | 0.97 | FALSE |