Best TWAS P=4.08e-13 · Best GWAS P=4.49e-13 conditioned to 0.254
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NPM3 | 0.03 | 0.01 | lasso | 2 | 0.03 | 1.2e-04 | 7.1 | -6.9 | 4.8e-12 | -0.82 | 0.01 | 0.96 | FALSE |
| 2 | GTEx | Liver | ACTR1A | 0.15 | 0.00 | lasso | 10 | 0.00 | 4.6e-01 | 5.1 | 6.4 | 1.9e-10 | 0.34 | 0.08 | 0.06 | TRUE |
| 3 | GTEx | Pancreas | NPM3 | 0.20 | 0.15 | lasso | 4 | 0.07 | 5.4e-04 | 7.1 | -6.9 | 5.8e-12 | -0.93 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Testis | NPM3 | 0.13 | 0.15 | lasso | 3 | 0.13 | 2.5e-06 | 7.1 | -7.1 | 1.2e-12 | -0.94 | 0.01 | 0.98 | FALSE |
| 5 | METSIM | Adipose | HPS6 | 0.05 | 0.03 | bslmm | 284 | 0.02 | 1.6e-03 | 5.4 | 5.2 | 2.5e-07 | 0.36 | 0.12 | 0.32 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | NPM3 | 0.05 | 0.01 | blup | 257 | 0.04 | 1.5e-05 | 7.1 | -5.3 | 1.2e-07 | -0.74 | 0.02 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | C10orf76 | 0.16 | 0.07 | lasso | 2 | 0.06 | 2.1e-04 | 5.3 | 6.1 | 1.2e-09 | 0.53 | 0.04 | 0.67 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NPM3 | 0.04 | 0.02 | blup | 22 | 0.02 | 1.8e-03 | 7.2 | -5.6 | 2.2e-08 | -0.78 | 0.00 | 0.66 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NPM3 | 0.02 | 0.03 | lasso | 3 | 0.02 | 9.2e-04 | 7.1 | -7.3 | 4.1e-13 | -0.94 | 0.00 | 0.87 | TRUE |
| 10 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C10orf76 | 0.19 | 0.20 | lasso | 1 | 0.18 | 4.6e-07 | 7.1 | 7.1 | 1.1e-12 | 0.93 | 0.01 | 0.99 | FALSE |