Best TWAS P=6.77e-09 · Best GWAS P=6.55e-09 conditioned to 0.135
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | CHST10 | 0.18 | 0.04 | lasso | 4 | 0.05 | 5.6e-03 | -5.5 | 5.8 | 6.8e-09 | -0.88 | 0.03 | 0.92 | TRUE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | CHST10 | 0.25 | 0.15 | lasso | 4 | 0.12 | 9.1e-05 | 5.0 | -5.4 | 5.4e-08 | 0.89 | 0.04 | 0.91 | FALSE |
| 3 | GTEx | Muscle Skeletal | LONRF2 | 0.07 | 0.08 | lasso | 4 | 0.08 | 2.5e-08 | -5.3 | -5.3 | 9.2e-08 | 0.98 | 0.06 | 0.94 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | LONRF2 | 0.05 | 0.03 | lasso | 2 | 0.02 | 9.3e-03 | 5.6 | -5.5 | 3.2e-08 | 0.93 | 0.04 | 0.89 | FALSE |
| 5 | GTEx | Thyroid | CHST10 | 0.05 | 0.05 | lasso | 5 | 0.03 | 2.6e-03 | -5.5 | -5.5 | 5.2e-08 | 0.94 | 0.03 | 0.95 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LONRF2 | 0.06 | 0.04 | blup | 69 | 0.04 | 3.4e-05 | 5.3 | -5.6 | 2.1e-08 | 0.82 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AFF3 | 0.06 | 0.00 | blup | 244 | 0.01 | 1.3e-02 | 3.8 | -5.2 | 1.9e-07 | 0.36 | 0.01 | 0.17 | FALSE |