Best TWAS P=6.28e-09 · Best GWAS P=5.85e-09 conditioned to 0.163
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ELOVL7 | 0.04 | 0.03 | blup | 355 | 0.03 | 1.4e-04 | 4.5 | -5.6 | 2.6e-08 | 0.82 | 0.06 | 0.94 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | GNL3LP1 | 0.21 | 0.17 | lasso | 10 | 0.12 | 6.2e-04 | 5.3 | 5.7 | 1.6e-08 | -0.78 | 0.12 | 0.78 | FALSE |
3 | GTEx | Brain Hippocampus | GNL3LP1 | 0.51 | 0.04 | enet | 2 | 0.14 | 4.1e-04 | 5.2 | 5.2 | 1.6e-07 | -0.73 | 0.05 | 0.34 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | ERCC8 | 0.08 | 0.04 | lasso | 6 | 0.05 | 1.7e-04 | -5.6 | -5.4 | 5.5e-08 | 0.91 | 0.02 | 0.97 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | GNL3LP1 | 0.05 | 0.10 | lasso | 2 | 0.09 | 1.4e-07 | 5.3 | 5.3 | 1.2e-07 | -0.76 | 0.11 | 0.89 | FALSE |
6 | GTEx | Esophagus Mucosa | ERCC8 | 0.16 | 0.06 | enet | 11 | 0.09 | 1.3e-06 | -5.5 | -5.8 | 7.1e-09 | 0.87 | 0.02 | 0.98 | FALSE |
7 | GTEx | Pancreas | SMIM15 | 0.10 | 0.03 | enet | 22 | 0.05 | 3.8e-03 | -5.6 | 5.1 | 2.7e-07 | -0.71 | 0.04 | 0.58 | FALSE |
8 | GTEx | Skin Not Sun Exposed Suprapubic | ELOVL7 | 0.14 | 0.09 | lasso | 3 | 0.08 | 6.3e-05 | -5.5 | 5.7 | 9.3e-09 | -0.90 | 0.02 | 0.93 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ERCC8 | 0.07 | 0.04 | lasso | 3 | 0.04 | 4.7e-05 | -5.6 | -5.6 | 2.0e-08 | 0.99 | 0.00 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | ERCC8 | 0.04 | 0.01 | blup | 39 | 0.01 | 8.1e-03 | -3.7 | -5.8 | 6.3e-09 | 0.90 | 0.01 | 0.66 | TRUE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ERCC8 | 0.06 | 0.04 | lasso | 1 | 0.02 | 2.3e-03 | -5.6 | -5.6 | 1.9e-08 | 1.00 | 0.00 | 0.97 | FALSE |