Hub : Genes

ELOVL7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0370 0.0160 1.6e-04 0.033 0.029 0.023 0.026 0.028 5.8e-05 1.4e-04 6.7e-04 3.6e-04 2.1e-04
2 GTEx Adrenal Gland 0.3914 0.1074 2.4e-05 -0.008 NA 0.083 NA 0.000 9.4e-01 NA 6.7e-04 NA 3.1e-01
3 GTEx Cells Transformed fibroblasts 0.1250 0.0430 3.5e-04 0.054 NA 0.074 NA 0.031 7.1e-05 NA 3.4e-06 NA 2.0e-03
4 GTEx Colon Transverse 0.1930 0.0720 1.6e-04 0.073 NA 0.094 NA 0.123 2.3e-04 NA 3.2e-05 NA 2.0e-06
5 GTEx Esophagus Mucosa 0.0820 0.0390 5.5e-03 0.040 NA 0.048 NA 0.044 1.0e-03 NA 3.5e-04 NA 6.5e-04
6 GTEx Muscle Skeletal 0.0875 0.0331 5.3e-05 0.032 NA 0.052 NA 0.057 3.9e-04 NA 7.1e-06 NA 2.9e-06
7 GTEx Nerve Tibial 0.1902 0.0546 5.4e-07 0.134 NA 0.119 NA 0.148 9.6e-10 NA 9.9e-09 NA 1.1e-10
8 GTEx Pancreas 0.1610 0.0830 6.4e-03 0.111 NA 0.049 NA 0.074 2.2e-05 NA 3.8e-03 NA 4.8e-04
9 GTEx Skin Not Sun Exposed Suprapubic 0.1420 0.0520 9.9e-04 0.090 NA 0.062 NA 0.075 1.2e-05 NA 2.6e-04 NA 6.3e-05
10 GTEx Small Intestine Terminal Ileum 0.2370 0.0930 1.4e-03 0.083 NA 0.050 NA 0.046 6.7e-03 NA 2.9e-02 NA 3.5e-02
11 GTEx Stomach 0.1540 0.0580 7.9e-05 0.135 NA 0.159 NA 0.064 5.3e-07 NA 4.7e-08 NA 5.3e-04
12 NTR Blood 0.0268 0.0135 2.8e-04 0.007 0.008 0.009 0.010 0.009 2.1e-03 7.2e-04 3.9e-04 2.7e-04 5.9e-04
13 YFS Blood 0.0256 0.0085 3.5e-09 0.036 0.028 0.033 0.029 0.033 6.7e-12 1.4e-09 6.3e-11 7.9e-10 5.5e-11
14 TCGA Breast Invasive Carcinoma 0.0199 0.0113 2.5e-03 0.009 0.009 0.006 NA 0.011 4.9e-03 4.8e-03 1.5e-02 NA 2.2e-03
15 TCGA Colon Adenocarcinoma 0.0550 0.0310 1.9e-03 0.075 0.022 0.022 NA 0.024 4.0e-05 2.0e-02 1.8e-02 NA 1.4e-02
16 TCGA Kidney Renal Clear Cell Carcinoma 0.0616 0.0254 9.6e-07 0.073 0.071 0.067 NA 0.071 1.2e-08 2.1e-08 4.8e-08 NA 2.2e-08
17 TCGA Liver Hepatocellular Carcinoma 0.1940 0.0790 2.0e-06 0.097 0.157 0.172 NA 0.159 2.7e-05 7.7e-08 1.7e-08 NA 6.2e-08
18 TCGA Soft Tissue Sarcoma 0.1160 0.0550 1.3e-03 0.047 0.046 0.050 NA 0.062 8.7e-04 9.7e-04 5.8e-04 NA 1.4e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Bipolar Disorder (2018) 0.2 0.4 1.8 1.0 -0.2 -0.8 -0.0 0.4 0.6 0.2 -0.4 0.3 0.0 -0.8 -1.0 -1.4 0.1 0.1 -0.9 -0.1 -0.0
Bipolar Disorder or Schizophrenia 2.4 5.8 17.1 4.1 -0.5 -3.1 -1.9 -1.0 -0.1 2.6 -2.4 -3.2 0.0 -3.5 -1.9 -1.7 -1.6 -2.1 -3.8 -2.7 -1.6
Depressed Affect (Nagel 2018) 0.9 2.0 7.2 2.2 0.3 -0.9 -2.7 -1.6 0.0 0.3 0.4 -0.9 0.0 -2.0 -0.2 -0.2 -1.6 -2.0 -1.2 -1.7 -2.0
Depression (Nagel 2018) 1.7 2.6 7.6 2.4 0.8 -1.5 -2.8 -1.7 0.9 0.3 0.5 -1.0 0.0 -2.5 -1.1 -1.3 -1.1 -2.6 -1.9 -1.6 -1.3
Intelligence (Savage-Jansen 2018) 2.8 8.5 23.6 -4.9 -1.3 1.6 3.0 2.6 0.8 -2.7 2.3 4.6 0.0 4.1 0.9 0.9 2.3 4.1 4.2 3.7 1.6
Neuroticism (Nagel 2018) 0.3 0.6 2.5 1.6 -0.2 -1.0 -0.8 0.0 1.1 0.7 0.1 0.1 0.0 -1.1 -0.5 -1.2 0.3 -0.7 -1.3 -0.2 -0.1
Schizophrenia (2018) 3.8 7.9 20.3 4.5 -0.5 -3.3 -2.4 -1.7 -0.6 3.2 -2.8 -4.4 0.0 -3.8 -1.6 -1.1 -2.1 -2.8 -4.2 -3.4 -2.1
Schizophrenia vs Biploar Disorder 1.7 2.3 7.5 1.9 -0.6 -0.8 -1.7 -1.5 -0.5 1.0 -0.3 -2.7 0.0 -1.4 -1.4 -0.6 -1.9 -1.5 -1.7 -2.2 -2.0
Worry (Nagel 2018) 0.4 0.8 3.4 1.0 0.1 -1.1 0.2 0.9 1.5 0.9 0.3 -0.3 0.0 -0.3 -1.2 -1.8 1.0 -0.0 -1.2 0.6 0.6
Alzheimer’s Disease (in mother) 0.9 1.0 2.2 1.1 -0.0 -1.1 -1.1 -0.8 -0.2 0.5 -0.3 -1.5 0.0 -0.9 -1.4 -1.5 -1.1 -1.2 -1.4 -1.1 -0.9
Alzheimer’s Disease (in father) 1.4 1.6 3.8 1.9 -0.6 0.1 -1.8 -1.5 -1.2 -0.4 -1.2 -1.5 0.0 -1.8 0.8 0.4 -1.2 -1.5 -1.0 -1.9 -1.0
Alzheimer’s Disease (including proxy) 2.4 3.4 8.0 2.6 0.5 -1.2 -2.6 -1.8 -0.8 0.7 -0.9 -2.8 0.0 -2.1 -1.2 -1.3 -2.0 -2.8 -2.2 -2.5 -1.7
Crohns Disease (2017) 0.4 0.8 3.5 -0.5 0.7 -0.5 -0.9 -1.3 -0.7 0.2 0.9 -0.9 0.0 -0.3 0.1 1.1 -1.8 0.1 0.5 -0.8 -1.9
Irritable Bowel Disease (IBD) 0.2 0.5 1.7 -1.3 -0.4 -0.1 0.4 -0.2 -0.2 -0.9 1.1 0.5 0.0 0.9 0.7 1.2 -0.2 0.7 1.2 0.6 -0.3
Ulcerative Colitis (UC) 1.7 3.2 6.9 -2.2 -1.2 1.2 2.3 1.8 0.8 -2.0 1.1 2.2 0.0 2.6 0.9 1.1 2.0 1.7 2.3 2.5 1.9
Major Depression (MDD) 0.2 0.2 2.2 0.3 -1.5 0.4 0.6 0.5 0.1 0.2 -0.2 0.6 0.0 -0.0 0.4 -0.2 0.2 0.5 -0.1 0.3 0.5
Reaction Time 1.3 2.5 10.5 0.1 -2.0 -3.2 -1.0 -2.0 -1.5 2.7 -0.5 -1.0 0.0 -2.8 -0.8 0.5 -1.2 0.3 -1.4 -1.3 -1.4
Verbal and Numeric Reasoning (VNR) 2.5 6.0 17.8 -4.2 -1.2 1.0 2.2 2.3 0.5 -2.5 2.5 3.5 0.0 3.7 0.5 1.0 1.8 3.2 3.5 3.1 1.2
Breast Cancer 0.6 1.3 5.7 -0.2 -0.7 -0.3 0.0 -1.3 -2.4 -0.1 -1.0 0.3 0.0 -1.5 2.3 1.8 -1.2 0.5 1.0 -0.6 -0.9
Ovarian Cancer 0.6 0.8 4.1 2.0 0.0 0.7 -0.4 -0.1 0.0 -1.1 -1.4 -0.6 0.0 -1.3 0.3 -0.7 0.1 -1.0 -1.4 -0.8 0.8
Prostate Cancer 0.4 0.5 2.2 -0.4 -1.5 0.6 0.4 0.9 0.3 -0.9 -0.2 0.8 0.0 1.1 -0.1 0.1 0.4 0.1 1.1 0.9 0.6
Age at First Birth 0.7 1.0 5.4 -2.3 -1.2 -0.1 0.8 0.1 -0.6 -0.1 1.1 1.0 0.0 1.6 0.9 0.9 0.0 0.9 1.3 0.9 -0.7
Bipolar Disorder (2011) 1.1 1.0 4.5 -1.2 -2.1 -0.7 1.1 1.0 0.2 -0.5 0.2 1.9 0.0 0.6 0.3 -0.2 0.9 1.2 0.9 1.3 0.7
Body Mass Index (BMI) (2010) 1.1 1.5 4.6 0.7 1.0 -0.3 -2.1 -2.1 -0.9 0.2 -0.2 -1.3 0.0 -1.6 1.5 0.4 -1.3 -1.6 -0.5 -1.7 -1.4
Coronary Artery Disease (CAD) 0.7 0.9 2.7 1.6 1.4 0.5 -0.7 -0.4 0.8 -0.8 -0.8 -1.3 0.0 -0.4 -0.6 -1.1 -0.5 -1.5 -1.1 -1.0 0.2
Crohns Disease (2012) 0.4 0.6 3.3 -1.0 1.8 -1.5 -0.6 -0.7 0.2 0.8 1.2 -0.4 0.0 -0.2 -1.0 0.1 -0.3 -0.1 0.1 0.2 -0.5
Mean Putamen Volume 1.5 1.7 7.6 1.4 1.9 2.0 -2.0 -0.5 0.6 -1.7 1.3 -0.1 0.0 -0.4 -0.2 -0.2 -0.7 -2.7 0.3 -1.0 -1.5
Fasting Glucose 1.6 1.9 5.6 2.4 -0.1 -0.7 -1.5 0.3 1.3 1.1 -1.2 -2.0 0.0 -0.4 -0.8 -1.8 -0.9 -2.2 -2.1 -1.4 -0.9
HbA1C 0.7 0.8 3.6 1.0 0.5 -0.1 0.3 0.1 -0.4 1.9 -1.9 -1.5 0.0 -0.1 -0.1 0.1 -0.7 0.4 -1.2 -0.8 0.1
HDL Cholesterol 0.1 0.1 0.6 -0.1 -0.7 -0.7 -0.1 0.6 0.2 0.1 0.3 -0.0 0.0 0.5 -0.8 -0.3 0.2 0.2 0.0 0.2 -0.2
LDL Cholesterol 2.0 3.2 11.4 1.0 -1.1 -0.3 -2.1 -2.5 -2.3 0.7 -1.2 -1.9 0.0 -1.1 1.8 1.5 -3.4 -1.1 -0.4 -2.5 -2.8
Lupus 0.3 0.4 1.8 -1.4 -0.3 0.1 0.4 -0.3 -0.7 -0.7 0.8 1.2 0.0 0.6 0.6 0.0 0.0 1.0 0.5 0.2 -0.7
Neuroticism (2016) 0.9 1.3 4.2 1.5 0.6 -1.3 -1.9 -1.3 -1.0 0.9 -0.7 -0.5 0.0 -2.0 0.4 0.1 -1.3 -0.8 -1.2 -1.4 -0.9
Primary Biliary Cirrhosis 0.9 1.2 4.9 0.5 -1.9 1.1 1.6 1.4 0.4 -0.6 -2.2 -0.2 0.0 1.6 0.3 -0.1 0.6 1.2 -0.2 0.3 1.6
Rheumatoid Arthritis 1.3 1.8 8.2 1.0 0.9 0.2 -0.6 1.3 2.9 -0.1 1.4 0.5 0.0 1.6 -1.6 -2.5 0.9 -1.9 -0.7 0.8 0.6
Schizophrenia (2014) 3.5 7.7 20.5 4.5 -1.3 -3.1 -3.0 -2.0 -0.2 2.3 -2.1 -3.4 0.0 -4.3 -2.1 -1.6 -2.5 -2.8 -3.8 -3.5 -2.5
Triglycerides 0.2 0.3 1.4 0.6 0.9 0.0 -0.9 -0.1 0.7 -0.2 1.2 -0.3 0.0 -0.4 -0.4 -0.3 -0.1 -0.9 0.2 -0.1 -0.9
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.6 1.2 0.8 -0.2 0.3 0.1 0.9 0.9 -0.3 -0.6 0.0 -0.7 -0.3 -1.1 0.3 -0.1 -1.2 -0.1 0.8
Ulcerative Colitis 0.8 1.2 3.0 -1.2 -1.3 -0.9 1.6 1.0 0.8 -0.1 0.3 1.1 0.0 1.3 0.2 -0.1 1.4 1.2 0.5 1.7 1.7
Blood Eosinophil Count 0.1 0.7 3.3 0.5 -0.1 0.7 -0.9 -0.2 0.5 -0.1 0.9 0.6 0.0 0.3 1.4 -0.7 -1.5 -0.4 0.1 -0.6 -1.8
Blood Platelet Count 1.1 12.3 45.6 -0.4 -4.3 3.8 -0.1 -0.8 -4.8 -3.4 -3.4 1.5 0.0 0.0 6.8 5.8 -3.9 1.3 4.8 -2.0 -4.0
Blood Red Count 0.9 8.4 25.8 -1.3 1.7 2.6 1.0 4.5 5.1 -2.9 4.0 3.0 0.0 4.7 -1.9 -3.0 2.6 0.1 1.9 3.2 1.7
Blood White Count 0.1 0.6 1.6 0.6 0.0 -0.5 0.6 1.3 0.8 1.1 -0.7 -0.5 0.0 1.1 1.0 -1.3 -0.4 0.7 -0.7 0.4 -0.1
Heel T-Score 0.2 1.7 6.5 2.5 2.1 0.8 -1.6 0.0 0.7 0.1 -0.5 -1.6 0.0 -1.1 -0.9 -1.6 -0.6 -1.9 -1.5 -1.1 -0.7
BMI 0.3 2.0 7.7 -2.8 0.6 0.9 0.7 0.2 0.8 -0.8 2.1 2.6 0.0 1.9 2.2 0.1 0.7 0.6 1.5 1.4 0.0
Height 0.4 8.6 27.1 -3.2 0.5 1.4 0.7 3.9 3.5 -2.5 4.3 4.4 0.0 5.2 -3.1 -2.6 2.4 0.5 2.6 3.6 0.6
Waist Hip Ratio (WHR) 1.4 6.1 20.2 4.5 1.9 -2.0 -1.9 -1.2 0.3 3.1 -2.7 -3.5 0.0 -2.9 -1.1 -1.2 -1.8 -1.9 -4.4 -2.9 -1.1
Systolic Blood Pressure 0.3 1.7 6.7 1.2 2.6 0.7 0.8 1.2 2.1 0.3 0.0 -0.3 0.0 -0.4 -0.1 -1.6 2.0 -0.6 -1.1 1.3 2.3
Smoking Status 6.0 14.3 36.6 3.5 0.1 -1.0 -4.4 -5.6 -4.6 1.5 -2.3 -4.3 0.0 -5.4 2.1 1.6 -5.6 -2.7 -2.5 -6.0 -5.3
Allergy or Eczema 1.6 4.2 10.7 -2.0 1.1 1.1 2.1 2.5 2.0 -1.0 1.3 3.3 0.0 3.0 -0.7 -0.8 2.7 2.1 1.4 3.2 2.6
Cardiovascular Disease 1.0 3.4 15.1 1.8 2.4 0.1 0.1 1.7 3.9 -0.1 1.1 -0.5 0.0 0.8 -2.4 -3.5 2.2 -0.9 -1.7 1.4 2.1
Hypothyroidism (self reported) 0.3 0.7 3.4 -1.9 0.6 -0.2 0.2 0.1 -0.1 -0.9 1.3 0.8 0.0 1.0 -0.8 -0.0 0.8 0.6 1.3 0.9 0.7
Respiratory disease 0.8 1.8 3.7 -1.0 0.2 1.6 1.5 1.5 1.4 -1.7 1.0 1.7 0.0 1.5 0.2 0.2 1.9 1.1 1.5 1.9 1.7
Type 2 Diabetes (T2D) (2018) 0.9 1.7 6.8 1.3 1.1 -1.9 -1.0 -1.5 0.8 2.6 0.4 -1.2 0.0 -1.8 -1.0 -1.1 -0.6 -0.7 -2.3 -1.0 -0.4
Lung FEV1/FVC ratio 0.9 4.8 14.1 -3.4 -0.5 1.0 2.1 2.2 1.8 -1.5 2.3 3.8 0.0 3.5 -0.5 -0.2 2.8 1.5 2.3 3.0 1.7
Lung FVC 0.8 4.2 14.5 3.3 -2.3 -0.4 -0.7 -1.8 -1.5 0.0 -3.8 -2.7 0.0 -3.3 0.6 1.1 -1.7 -0.2 -2.6 -3.1 -0.4
Neuroticism 0.2 0.4 3.2 0.7 -0.5 -0.6 -0.7 -0.5 -0.5 -0.1 0.3 0.9 0.0 -1.8 0.5 0.2 0.2 -0.1 -0.1 -0.3 -0.5
Chronotype (morning person) 0.8 1.9 9.4 -0.9 -0.3 2.8 -0.2 0.4 0.4 -3.1 1.6 1.4 0.0 2.0 1.0 0.7 -0.1 -0.4 2.0 0.5 -0.5
Hair Pigment 0.0 1.3 5.7 -1.1 0.3 -0.3 1.2 -1.6 -2.0 1.1 -0.8 -0.3 0.0 -1.1 1.6 2.4 -0.4 1.6 -0.2 -0.8 -0.0
Tanning 0.5 6.0 15.4 3.1 -2.0 -2.2 -3.9 -2.1 0.4 1.1 0.8 -3.1 0.0 -3.8 -3.2 -1.7 -2.1 -2.7 -2.6 -2.7 -2.3
Hand grip strength (left) 0.6 1.6 4.4 -1.7 -1.5 -1.4 -0.3 -0.9 -2.1 -0.4 -0.5 1.2 0.0 -0.0 1.8 2.0 -1.4 1.2 1.4 -0.6 -1.5
Number of treatments/medications taken 1.0 1.9 5.1 -0.4 0.1 -0.1 1.7 1.7 2.0 1.2 0.5 0.3 0.0 2.1 -1.2 -2.3 1.9 0.9 -0.7 1.9 1.5
Average weekly spirits intake 1.0 1.2 2.9 1.7 -0.1 0.6 -1.0 -1.0 -0.8 -0.1 -1.4 -1.5 0.0 -1.0 0.7 -0.4 -1.0 -1.4 -1.7 -1.7 -0.8
Sensitivity / hurt feelings 0.7 1.2 6.2 1.0 0.7 -0.1 1.0 1.7 1.4 -0.2 -1.0 0.3 0.0 -0.2 -0.5 -0.6 2.3 -0.1 -0.4 1.2 2.5
Frequency of depressed mood in last 2 weeks 1.6 2.2 6.1 2.4 0.7 -1.1 -2.3 -1.7 -0.0 0.6 -0.6 -1.3 0.0 -2.5 -0.3 -0.6 -1.1 -2.3 -1.8 -1.8 -1.4
Hearing difficulty/problems: Yes 0.3 0.4 1.5 -0.9 1.2 1.1 -0.1 -0.4 0.1 -0.0 0.7 0.7 0.0 0.6 1.2 0.4 0.2 -0.3 0.7 0.5 0.2
Relative age of first facial hair 1.3 2.7 11.4 0.5 3.0 -0.1 -1.1 1.2 2.4 0.2 2.4 -0.3 0.0 1.7 -3.4 -2.9 0.1 -1.2 -0.3 0.6 -0.5
Other serious medical condition/disability diagnosed by doctor 1.5 1.9 5.0 -1.0 1.7 -0.8 0.9 1.5 2.2 0.8 1.1 0.9 0.0 2.0 -0.9 -2.2 1.7 0.4 -0.5 1.8 1.7
Ever used hormone-replacement therapy (HRT) 0.5 0.6 2.4 -0.1 0.7 -1.1 0.4 0.5 0.5 1.4 -0.1 -0.4 0.0 0.4 -1.5 -1.5 0.5 0.3 -0.8 0.6 0.6
Ever had hysterectomy (womb removed) 1.3 1.4 5.4 2.0 1.0 -0.2 -0.9 -1.0 -0.2 0.9 -1.4 -2.3 0.0 -1.3 -0.8 -0.3 -0.9 -1.3 -1.9 -1.5 -0.4
Systolic blood pressure, automated reading 0.5 1.3 4.9 0.4 0.5 1.8 1.0 1.4 2.2 -1.2 0.8 0.6 0.0 0.8 -0.1 -1.4 1.8 -0.3 -0.1 1.2 1.8
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 4.0 0.5 -1.3 0.3 1.5 0.7 0.3 0.6 -2.0 -0.4 0.0 0.1 1.0 -0.1 0.4 1.3 -0.7 0.1 0.9
Angina 0.2 0.3 1.6 0.8 -0.2 -0.1 -0.4 -0.3 0.4 0.2 -0.2 -0.4 0.0 -0.4 -0.5 -1.2 0.3 -0.8 -1.1 -0.2 0.3
Medication for hormone replacement therapy 0.4 0.5 2.0 0.2 1.4 0.6 -0.9 -0.4 -0.2 0.2 0.7 -1.0 0.0 0.1 -0.6 -0.8 -0.6 -1.0 -0.2 -0.5 -0.9
Vitamin and mineral supplements 2.7 3.7 9.5 1.7 -0.3 -0.8 -2.0 -2.6 -2.2 1.0 -1.2 -3.1 0.0 -2.9 1.1 1.5 -2.5 -1.5 -1.1 -2.8 -2.3
Supplements: Zinc 1.2 1.3 5.3 -1.4 0.6 0.8 0.4 1.2 0.9 -0.5 1.5 2.3 0.0 1.5 -0.6 -0.7 1.2 0.4 1.1 1.7 0.6
Medication: Co-codamol 0.7 0.8 2.3 -0.3 -0.5 0.6 1.5 -0.3 -1.3 0.7 -1.5 -1.5 0.0 0.5 0.9 0.4 -0.8 1.3 -0.3 -0.5 -0.2
Medication: Metformin 0.5 0.7 6.0 0.0 -0.6 -1.3 0.6 -0.9 0.0 2.5 -0.0 -0.6 0.0 -1.1 0.7 0.0 -0.4 1.1 -0.8 -0.2 -0.3
Diabetes (father) 0.7 0.8 3.1 0.3 1.0 -0.7 -1.5 -0.1 1.1 -0.1 1.5 -0.7 0.0 0.8 -1.6 -0.8 -0.0 -1.7 -0.2 0.1 -0.3
Diabetes (mother) 0.6 0.8 2.5 0.4 -0.8 1.6 1.5 1.0 -0.1 -0.7 -1.6 -0.4 0.0 0.5 0.3 -0.5 1.0 0.6 -0.1 0.5 1.6
Severe depression (siblings) 0.3 0.3 1.2 -0.6 0.1 0.2 -0.1 0.6 0.2 -1.0 0.6 0.9 0.0 1.1 -0.1 0.0 0.3 -0.3 1.0 0.6 0.2
Pack years adult smoking proportion 1.4 2.2 8.9 0.8 1.7 -0.1 0.5 1.9 3.0 -0.2 0.2 0.4 0.0 1.5 -2.1 -2.8 1.8 -0.2 -0.8 1.4 1.5
Impedance of leg (right) 1.1 5.4 23.0 4.8 -0.8 -0.5 -1.1 -0.3 -0.9 1.5 -4.8 -4.0 0.0 -2.3 -0.4 -0.5 -2.1 -1.1 -3.2 -2.8 -0.7
Leg fat-free mass (left) 0.9 4.7 17.1 -4.1 1.2 0.3 1.1 1.4 1.4 -1.1 3.7 3.8 0.0 3.4 0.5 -0.1 1.9 0.9 2.6 2.9 0.5
Trunk fat percentage 0.4 1.8 4.6 1.3 1.8 0.0 -1.1 -1.4 -0.3 1.6 -0.6 -2.1 0.0 -0.8 1.0 -0.6 -1.5 -1.5 -1.8 -1.8 -1.7
Hand grip strength (right) 0.6 1.7 5.2 -1.7 -1.5 -1.9 -0.8 -1.3 -2.0 0.1 0.1 0.7 0.0 -0.3 1.3 1.6 -1.8 0.9 1.0 -1.1 -2.3
Townsend deprivation index at recruitment 1.6 2.3 6.9 2.4 -0.1 0.8 -0.7 -1.2 -1.1 1.0 -2.6 -2.2 0.0 -2.2 0.9 0.7 -1.6 -0.5 -1.9 -2.3 -1.0
Current tobacco smoking 2.6 4.2 11.6 2.5 0.4 0.4 -1.8 -2.8 -2.5 0.3 -1.7 -2.2 0.0 -3.4 2.5 1.1 -2.6 -1.7 -0.9 -2.9 -2.3
Average weekly fortified wine intake 1.2 1.4 6.1 -1.9 -0.6 1.2 0.2 0.1 -0.2 -1.5 1.7 2.0 0.0 0.7 1.2 1.3 0.0 0.2 2.5 0.8 -0.9
Maternal smoking around birth 2.4 3.5 8.8 1.0 -0.8 0.2 -1.1 -3.0 -2.9 1.1 -1.4 -1.8 0.0 -2.7 2.3 2.2 -2.7 -0.5 -0.7 -2.5 -2.2
Fed-up feelings 2.0 3.6 9.1 2.3 0.5 -2.2 -2.5 -2.6 -0.8 1.7 -0.5 -2.6 0.0 -3.0 -0.1 -0.4 -2.0 -1.6 -2.2 -2.4 -2.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.2 6.4 2.0 1.2 -1.3 -2.4 -2.0 -0.1 0.9 -0.6 -1.3 0.0 -2.5 0.2 -0.4 -1.4 -1.5 -1.8 -1.8 -1.5
Relative age voice broke 0.7 1.1 5.2 -0.2 1.3 0.7 -1.0 0.0 0.5 -1.6 2.3 0.0 0.0 0.9 -1.1 -0.4 -0.6 -1.2 1.5 0.2 -1.4
Taking other prescription medications 1.3 2.1 5.4 -0.5 0.5 0.1 1.6 2.3 2.1 0.4 0.2 0.5 0.0 2.1 -1.2 -2.1 1.8 1.2 -0.3 1.9 2.3
Age when periods started (menarche) 0.4 1.0 4.8 0.3 -0.2 1.7 -0.1 -0.9 -1.4 -1.1 -1.0 -0.0 0.0 -0.3 2.2 1.7 -0.6 -0.4 0.7 -0.8 -0.5
Bilateral oophorectomy (both ovaries removed) 1.7 1.9 4.9 1.6 -0.6 -1.4 -1.5 -0.9 -0.4 2.1 -1.2 -2.2 0.0 -1.2 -0.9 -0.7 -1.7 -1.0 -1.9 -1.9 -1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.8 -0.3 0.5 0.9 0.3 0.7 0.4 -0.4 -0.1 0.3 0.0 0.9 0.4 -0.5 0.2 0.6 0.4 0.6 0.0
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 5.5 -1.3 1.3 0.3 1.9 2.2 1.0 -0.5 0.0 1.2 0.0 2.0 -0.3 -0.2 2.2 1.2 1.0 2.1 2.3
Qualifications: CSEs or equivalent 2.6 3.5 10.7 2.0 1.0 -1.1 -2.3 -2.0 -2.0 1.1 -1.8 -3.3 0.0 -2.3 0.9 -0.2 -2.4 -2.2 -1.9 -2.3 -1.7
Serious illness, injury or assault to yourself 1.3 1.6 6.7 -1.8 -0.0 -0.5 0.2 0.8 1.6 -0.2 2.6 1.1 0.0 2.3 -1.6 -1.3 0.9 0.5 0.8 1.5 0.5
High blood pressure 1.8 5.0 21.0 0.7 1.2 -0.5 1.3 2.6 4.6 0.4 2.0 -0.0 0.0 1.6 -3.4 -4.0 2.9 0.1 -1.6 2.2 2.8
Hayfever, allergic rhinitis or eczema 1.5 3.3 8.8 -2.3 1.1 0.1 2.1 2.3 1.5 -0.4 1.1 2.6 0.0 3.0 -0.3 -0.4 2.2 2.2 1.2 2.9 2.2
Multivitamins +/- minerals 4.7 5.9 14.4 -2.8 0.7 0.8 2.5 3.0 2.4 -1.3 2.5 3.8 0.0 3.5 -1.0 -1.6 3.3 1.7 1.9 3.8 2.6
Stomach or abdominal pain in last month 0.9 1.1 4.0 0.1 0.9 0.6 -1.3 1.0 1.5 -0.9 1.2 -0.5 0.0 1.2 -1.9 -1.0 0.5 -2.0 0.6 0.7 -0.0
Supplements: Glucosamine 2.0 2.6 8.8 -2.5 -1.4 0.8 1.6 1.1 0.2 -1.5 0.7 3.0 0.0 1.9 0.4 0.4 1.6 2.0 2.1 2.2 1.7
Diverticular disease/diverticulitis (self-reported) 2.1 2.5 6.6 0.6 1.3 -2.6 -2.0 -1.4 -0.8 2.3 -0.2 -1.9 0.0 -0.9 -1.6 -1.2 -1.8 -1.1 -2.3 -1.5 -1.9
Medication: Atenolol 0.9 1.2 3.3 -0.3 0.3 1.5 1.6 1.8 0.9 -0.6 -0.6 0.1 0.0 1.3 -0.4 -0.4 1.8 1.0 0.5 1.3 1.8
Medication: Levothyroxine sodium 0.6 1.1 3.8 -1.4 -0.9 1.0 0.5 -1.0 -1.4 -1.3 1.0 0.8 0.0 -1.1 1.2 2.0 0.1 0.3 1.6 -0.1 -0.2
Sitting height 0.3 2.0 6.8 -1.0 0.9 0.2 0.9 2.4 2.2 -0.4 1.3 1.7 0.0 2.6 -1.4 -1.8 1.4 0.7 0.2 1.7 0.9
Chronic bronchitis/emphysema (father) 0.6 0.7 3.3 0.6 -0.6 0.4 -0.2 -1.0 -1.2 -0.1 -1.8 -0.4 0.0 -1.0 1.8 0.8 -0.7 -0.2 -0.3 -1.0 -0.1
High blood pressure (mother) 0.3 0.4 1.4 -1.2 0.0 0.5 0.6 -0.2 -0.3 -1.1 0.5 0.7 0.0 0.3 -0.5 0.3 0.7 0.6 0.7 0.7 1.2
Body mass index (BMI) 0.1 0.6 3.2 -1.5 0.8 0.9 0.2 -0.2 0.1 -0.2 1.0 0.6 0.0 0.8 1.8 0.4 0.1 -0.2 0.9 0.3 -0.5
Impedance of leg (left) 1.1 5.4 23.6 4.9 -0.8 -0.7 -1.5 -0.7 -0.5 1.7 -3.8 -4.0 0.0 -2.6 -1.2 -1.1 -2.0 -1.6 -3.4 -2.9 -0.9
Leg predicted mass (left) 0.9 4.8 17.4 -4.2 1.2 0.3 1.2 1.4 1.5 -1.1 3.8 3.8 0.0 3.5 0.5 -0.2 1.9 1.0 2.6 2.9 0.5
Trunk fat mass 0.1 0.6 2.4 -0.0 1.6 0.1 -0.6 -0.7 0.2 1.0 0.4 -0.8 0.0 0.3 0.9 -0.7 -0.8 -0.9 -0.9 -0.8 -1.3
Waist circumference 0.1 0.3 1.6 -0.3 1.2 0.0 0.4 -0.0 0.6 1.3 0.1 -0.0 0.0 0.3 1.1 -0.5 0.1 -0.2 -0.8 -0.1 -0.4
Number of incorrect matches in round 0.9 1.6 7.0 1.3 0.4 -2.1 -0.3 0.9 1.5 1.4 0.0 -0.8 0.0 -0.0 -2.6 -2.4 0.5 -1.0 -1.4 0.4 0.4
Past tobacco smoking 3.7 6.8 19.9 -1.5 0.4 0.7 2.7 4.2 3.5 -1.1 1.2 2.7 0.0 4.5 -0.6 -1.7 3.5 1.2 1.6 4.2 3.6
Alcohol usually taken with meals 4.5 7.3 18.4 -4.3 -1.2 1.1 2.7 2.4 1.8 -2.1 3.2 4.2 0.0 3.7 -0.4 0.5 2.7 2.4 3.9 3.7 2.2
Nervous feelings 0.5 1.0 4.2 0.7 0.4 0.5 1.4 2.0 1.2 0.1 -0.9 0.4 0.0 0.7 -0.0 -1.0 1.4 0.8 -0.6 1.0 1.6
Frequency of tenseness / restlessness in last 2 weeks 1.9 3.0 7.6 2.5 2.1 -2.4 -1.8 -0.8 1.0 2.6 -0.1 -1.8 0.0 -2.0 -1.2 -1.8 -1.0 -1.7 -2.8 -1.4 -1.3
Hearing difficulty/problems with background noise 0.8 1.3 5.3 1.9 1.1 1.3 -1.6 -0.4 0.5 -0.5 -0.6 -1.5 0.0 -0.4 0.4 -0.6 -1.1 -2.3 -1.0 -1.4 -0.8
Hair/balding pattern: Pattern 2 0.1 0.1 0.7 -0.2 0.6 -0.2 -0.0 -0.0 -0.4 -0.7 -0.4 -0.9 0.0 0.6 0.3 0.1 -0.1 -0.2 0.2 -0.1 -0.0
Had menopause 0.4 0.5 1.3 -0.5 -0.1 0.3 0.9 0.8 0.9 -0.2 0.4 0.6 0.0 0.5 -0.8 -1.2 1.2 0.2 -0.2 0.9 1.1
Had other major operations 1.7 2.1 4.3 -1.2 1.3 1.8 1.6 1.3 1.8 -1.5 1.2 2.1 0.0 1.6 0.3 -0.4 1.7 1.2 1.4 2.0 1.8
Forced vital capacity (FVC) 0.2 0.9 4.9 2.2 -0.3 0.7 -0.4 -0.1 0.9 -1.7 -1.0 -0.5 0.0 -1.2 -0.9 -0.4 0.3 -0.9 -1.2 -0.8 0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 1.3 0.8 0.2 -0.0 0.1 0.3 0.5 0.7 -0.8 -0.6 0.0 -0.2 -0.2 -1.1 -0.1 0.5 -1.0 -0.1 0.2
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 3.7 -1.9 -0.8 -1.8 1.2 0.7 -0.6 0.6 1.2 1.3 0.0 0.4 0.2 1.1 0.7 1.9 1.6 1.3 0.1
Qualifications: None of the above 11.3 24.2 72.2 8.4 2.8 -2.5 -4.4 -4.0 -0.4 4.4 -4.2 -8.5 0.0 -6.5 -2.2 -2.8 -3.6 -5.4 -8.1 -6.1 -2.6
Financial difficulties in last 2 years 0.4 0.5 1.7 1.3 0.3 -0.7 -0.7 -0.5 0.4 0.2 -0.1 -1.3 0.0 -0.8 -0.3 -0.4 -0.7 -1.0 -0.7 -0.9 -1.0
Mouth/teeth dental problems 2.6 4.0 17.2 -4.1 -0.9 0.6 0.6 0.8 -0.9 -2.3 2.2 3.8 0.0 2.4 0.8 2.0 0.5 1.2 3.6 1.7 -0.4
Heart attack 0.3 0.4 2.0 0.2 -0.3 1.0 0.6 0.4 1.1 -0.7 0.5 1.4 0.0 0.1 0.3 -0.1 0.9 0.4 0.4 0.6 0.9
Allergy 1.3 3.1 7.0 1.7 -0.9 -1.4 -2.0 -2.2 -1.6 1.5 -0.7 -2.6 0.0 -2.3 -0.9 0.1 -2.4 -1.7 -1.4 -2.5 -2.3
Pain all over the body in last month 1.5 1.6 8.8 1.3 -3.0 -0.7 0.5 -0.3 -1.3 1.5 -1.8 -1.6 0.0 -1.4 0.8 0.6 -1.0 0.9 -1.3 -1.1 -0.6
Diabetes (self-reported) 1.3 2.0 7.2 1.6 1.0 -1.4 -1.2 -1.4 1.0 2.7 0.5 -1.5 0.0 -1.8 -1.1 -1.5 -0.4 -1.4 -2.3 -1.0 -0.5
Hayfever/allergic rhinitis (self-reported) 2.5 3.3 13.0 -1.7 0.1 -0.2 3.6 2.2 1.1 0.8 -0.5 0.6 0.0 2.4 0.5 -0.2 2.2 3.5 0.2 2.5 2.7
Medication: Ramipril 0.8 1.0 6.6 0.2 -0.0 -1.9 0.8 0.0 0.8 2.6 -0.3 -1.0 0.0 -0.0 -0.6 -0.7 0.3 1.2 -1.6 0.0 0.3
Medication: Simvastatin 1.1 1.6 5.6 1.9 1.4 -0.3 -0.6 0.7 2.0 1.3 -0.1 -1.8 0.0 -0.1 -1.7 -2.4 0.4 -0.6 -1.9 -0.2 0.4
Fluid intelligence score 2.0 4.2 10.6 -3.2 -1.0 0.5 2.0 2.0 0.7 -1.8 2.1 3.1 0.0 3.0 0.7 0.7 1.6 3.0 2.7 2.6 1.1
Illnesses of siblings 0.5 0.7 2.8 -0.1 -0.2 -0.2 -0.8 -0.8 -1.3 0.0 -0.1 -0.4 0.0 0.1 1.0 1.2 -1.7 -0.6 0.5 -1.0 -1.6
Neuroticism score 0.1 0.3 1.5 0.5 -0.8 -1.0 -0.7 -0.3 -0.1 0.1 0.3 0.4 0.0 -1.2 -0.1 0.2 -0.2 0.2 -0.0 -0.3 -0.6
Weight 0.3 1.7 5.8 -2.4 1.3 0.8 0.4 0.8 1.2 -0.6 2.3 1.9 0.0 2.4 0.7 -0.5 0.8 -0.0 1.3 1.4 -0.3
Impedance of arm (right) 1.7 7.8 22.3 4.5 1.2 -1.9 -2.3 -2.2 -1.1 3.1 -3.0 -4.7 0.0 -3.5 -1.2 -1.1 -2.8 -2.1 -4.4 -3.5 -1.8
Arm fat percentage (right) 0.4 1.4 3.1 0.6 1.5 -0.1 -0.9 -1.4 -0.5 1.6 -0.4 -1.8 0.0 -0.8 1.5 -0.1 -1.5 -1.0 -1.5 -1.6 -1.7
Trunk fat-free mass 1.4 8.2 27.0 -5.2 -0.1 0.5 1.6 2.5 1.8 -2.1 4.2 5.0 0.0 4.7 -0.5 -0.2 2.5 1.8 3.8 3.8 0.8
Hip circumference 0.7 3.2 10.8 -2.9 0.7 1.9 1.6 1.8 1.5 -1.4 2.3 2.3 0.0 3.3 0.8 -0.7 1.8 0.6 1.9 2.3 0.6
Time employed in main current job 1.6 1.8 6.9 -0.3 -1.2 -1.9 -2.0 -1.6 -0.4 1.4 1.7 -0.9 0.0 -0.9 -0.7 0.2 -1.9 -1.1 -0.3 -1.4 -2.6
Alcohol intake versus 10 years previously 1.4 2.1 6.2 2.5 1.0 -0.9 -2.0 -0.9 -0.1 1.6 -0.8 -1.4 0.0 -1.1 -0.2 -1.4 -1.7 -1.9 -2.2 -1.6 -1.7
Father’s age at death 2.3 3.0 10.1 -2.3 -0.0 -0.3 1.5 2.3 1.8 -0.3 2.1 3.2 0.0 2.6 -0.2 -0.9 1.7 1.4 1.7 2.5 1.5
Worrier / anxious feelings 0.4 0.7 2.0 -1.4 -1.4 -1.3 0.5 -0.0 -0.3 0.6 1.1 1.2 0.0 0.4 0.5 -0.3 0.2 1.4 0.6 0.7 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 5.1 0.3 -0.4 -2.2 -0.8 -0.5 0.5 1.8 0.0 -0.3 0.0 -0.5 -0.7 -0.4 -0.8 0.0 -0.8 -0.5 -0.8
Falls in the last year 1.7 2.3 8.1 -1.1 0.8 0.6 0.4 0.8 2.6 -0.0 2.8 1.0 0.0 2.4 -2.0 -2.8 1.4 0.3 -0.2 1.7 0.9
Hair/balding pattern: Pattern 3 0.4 0.6 2.3 -1.0 -1.5 0.7 1.3 0.3 -0.3 -0.7 -0.4 1.1 0.0 0.1 0.2 0.7 0.6 1.0 0.8 0.4 0.7
Number of live births 0.9 1.2 4.1 -0.3 1.1 1.8 1.1 1.5 0.9 -2.0 -0.6 0.7 0.0 0.8 0.7 0.2 1.4 0.2 1.0 1.0 1.8
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 3.4 1.1 0.3 0.8 0.5 0.8 1.5 -1.9 -0.4 0.4 0.0 0.1 -1.2 -0.6 1.4 -0.2 -0.7 0.4 1.6
Pulse rate 0.9 1.6 8.6 0.2 -0.2 1.6 1.6 0.6 -1.2 -0.8 -2.4 0.7 0.0 -0.6 2.9 1.3 0.4 1.6 0.9 0.0 0.8
Happiness 1.0 1.3 4.4 2.0 1.6 0.7 -2.0 -0.2 1.1 -1.2 0.3 -0.5 0.0 -0.4 -1.3 -1.0 -0.3 -2.1 -0.7 -0.7 -0.5
Noisy workplace 1.2 1.4 5.2 -1.7 -2.3 -0.0 0.7 -1.6 -1.0 0.5 1.4 0.5 0.0 0.1 1.4 1.7 -0.7 1.8 1.2 -0.3 -1.3
Qualifications: A levels/AS levels or equivalent 4.5 10.0 33.0 -5.6 -1.1 1.1 2.1 2.4 1.4 -2.7 4.1 5.7 0.0 4.4 0.4 0.5 2.7 2.8 4.8 4.4 1.4
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.6 -0.2 -0.5 0.2 -0.3 -0.2 0.7 -1.3 0.8 0.6 0.0 0.4 -1.0 0.1 0.1 0.0 0.9 0.3 -0.1
Mouth/teeth dental problems: Dentures 2.0 3.4 15.3 3.9 0.5 -0.1 -0.4 -1.1 0.1 1.2 -2.7 -3.3 0.0 -2.6 -0.5 -1.3 -0.5 -1.1 -3.3 -2.0 0.4
Asthma 0.4 0.7 2.0 -0.6 1.1 1.4 1.0 1.0 1.0 -1.1 0.7 0.5 0.0 0.9 0.8 0.1 0.9 0.8 0.7 0.9 0.9
Medication: Ibuprofen (e.g. Nurofen) 2.0 2.5 6.4 -1.2 0.4 1.0 1.1 1.8 2.0 0.0 2.2 1.4 0.0 2.5 -2.5 -1.7 1.9 0.5 0.6 2.3 1.6
Medication: Cholesterol lowering 0.4 0.6 3.8 1.2 0.3 0.1 0.1 0.3 1.2 0.6 -0.2 -0.6 0.0 0.1 -0.3 -2.0 0.5 -0.1 -1.5 -0.1 0.4
Depression (self-reported) 0.5 0.6 3.1 1.1 -1.1 -0.3 0.5 0.2 -0.4 0.7 -1.3 -1.8 0.0 -0.3 -0.6 -0.9 -0.1 0.1 -1.2 -0.2 0.1
Medication: Lansoprazole 0.8 1.0 4.3 2.1 -0.1 -0.5 -1.0 0.4 0.2 0.9 -1.5 -1.2 0.0 0.2 -0.9 -1.2 -0.9 -0.6 -1.5 -1.0 -0.7
Prospective memory result 0.3 0.4 2.0 -0.3 -0.7 1.4 0.6 -0.4 -0.1 -0.2 -0.1 -0.4 0.0 -0.6 1.0 1.2 0.3 -0.0 0.9 0.2 0.7
Lung cancer (father) 0.8 0.9 3.9 0.0 0.1 -0.7 0.8 -0.3 -1.4 2.0 -1.9 -1.5 0.0 -1.2 0.5 0.6 -0.4 1.0 -1.0 -0.4 0.2
Illnesses of mother 0.7 0.8 2.9 0.1 -0.8 -0.5 -0.2 -1.1 -0.8 1.1 -0.0 -0.1 0.0 -0.7 1.7 1.7 -1.2 0.5 0.1 -1.0 -1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.9 0.8 -0.4 0.8 0.7 0.8 1.1 -1.4 -0.4 0.1 0.0 0.4 -1.0 -0.4 1.1 -0.1 -0.6 0.4 1.1
Pulse wave Arterial Stiffness index 0.7 0.9 3.0 1.1 1.2 0.5 -0.3 1.1 1.6 -0.3 0.7 -0.6 0.0 0.3 -1.7 -1.7 0.6 -1.3 -0.6 0.3 0.4
Impedance of arm (left) 1.2 5.5 17.4 3.9 1.2 -1.9 -1.5 -1.4 -0.6 2.9 -2.5 -4.2 0.0 -2.6 -1.6 -1.6 -1.9 -1.5 -4.1 -2.5 -1.0
Arm fat mass (right) 0.1 0.5 2.2 -0.9 1.5 0.3 -0.5 -0.5 0.3 0.6 1.1 -0.0 0.0 0.7 1.1 -0.3 -0.5 -0.8 -0.0 -0.2 -1.2
Trunk predicted mass 1.4 8.1 26.6 -5.2 -0.1 0.5 1.6 2.4 1.8 -2.1 4.1 5.0 0.0 4.6 -0.5 -0.2 2.5 1.8 3.8 3.8 0.8
Standing height 0.4 4.2 13.5 -2.7 0.8 -0.5 0.3 2.2 2.4 -0.9 3.4 3.2 0.0 3.7 -2.3 -2.0 1.6 0.4 1.5 2.6 0.2
Length of working week for main job 1.9 2.2 6.3 -1.6 2.1 1.1 1.5 2.0 1.6 -0.5 1.4 0.7 0.0 2.5 -0.4 0.2 1.6 0.4 1.8 2.2 1.4
Exposure to tobacco smoke at home 3.4 3.8 10.7 2.0 1.6 -1.2 -2.9 -2.5 -1.5 1.1 -0.3 -1.8 0.0 -2.1 -0.0 0.3 -2.9 -2.5 -1.3 -2.8 -3.3
Breastfed as a baby 0.3 0.4 1.2 0.1 0.5 1.1 -0.9 -0.4 -0.6 -1.0 -0.7 0.2 0.0 -0.3 0.6 0.1 -1.0 0.2 0.3 -1.1 -0.6
Tense / ‘highly strung’ 0.8 1.3 3.5 1.2 1.2 -0.9 0.6 1.9 1.6 1.2 -0.8 -0.2 0.0 0.2 -1.9 -1.5 1.4 0.3 -1.1 0.8 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 4.1 -0.4 -2.0 0.0 -0.3 0.0 -0.2 -1.1 1.0 1.1 0.0 0.8 0.5 -0.2 -0.2 0.2 0.9 0.4 -0.8
Hair/balding pattern: Pattern 4 0.6 1.5 7.8 -1.4 0.0 -1.4 -0.9 0.3 1.2 0.9 2.8 1.8 0.0 0.9 -1.2 -0.6 0.7 -1.0 1.3 1.6 -0.5
Birth weight of first child 0.2 0.4 1.5 -0.3 0.7 0.5 0.5 1.0 0.4 0.2 0.3 0.5 0.0 1.2 0.2 -0.9 0.9 -0.3 0.3 1.2 0.8
Peak expiratory flow (PEF) 0.8 1.8 5.4 -0.2 1.6 0.0 -0.5 0.2 2.3 -2.2 2.3 0.8 0.0 0.4 -2.3 -0.9 1.8 -1.6 0.1 0.8 1.1
Pulse wave reflection index 1.0 1.2 6.9 1.3 0.4 -0.1 -0.7 0.1 1.4 0.3 0.9 -1.2 0.0 -0.8 -2.6 -1.6 0.2 -1.6 -1.4 -0.2 0.2
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.9 1.2 -0.7 -0.8 -0.2 -0.4 -0.2 0.8 -1.4 -0.8 0.0 -0.5 0.9 0.2 -0.8 0.2 -0.9 -0.9 -0.2
Loud music exposure frequency 0.4 0.5 2.7 0.5 0.5 -0.3 0.3 -0.4 -0.5 0.5 -1.0 -0.5 0.0 -1.6 1.2 1.3 0.1 -0.0 -0.1 -0.5 0.3
Qualifications: O levels/GCSEs or equivalent 3.4 5.4 20.0 -4.5 -1.9 0.9 1.3 0.5 -0.9 -2.1 2.0 3.7 0.0 2.8 1.7 2.7 0.4 2.7 4.2 2.1 -0.3
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 3.4 0.6 0.0 -1.1 0.7 0.6 1.1 1.6 -0.4 -1.4 0.0 -0.4 -1.9 -1.3 0.9 0.8 -1.6 0.4 1.0
Blood clot in the leg (DVT) 0.3 0.4 1.6 -0.4 0.8 1.2 0.2 0.3 -0.3 -0.8 0.4 0.4 0.0 0.6 1.3 0.9 -0.4 0.3 0.9 -0.1 -0.5
Medication: Paracetamol 0.3 0.5 3.0 0.9 0.2 -0.4 0.1 -0.3 -0.2 1.7 -0.2 -1.6 0.0 0.1 0.3 -0.2 -0.6 -0.3 -0.8 -0.5 -1.1
Headache pain in last month 0.6 1.0 4.5 0.5 -0.2 -1.6 -0.1 -0.5 0.1 2.1 -0.1 -1.8 0.0 0.1 -2.1 -0.8 -0.3 0.2 -1.4 -0.4 -0.6
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 6.2 -0.9 0.1 0.9 -0.1 -0.2 -1.7 -1.6 -0.6 0.4 0.0 -0.1 1.3 2.5 -0.6 -0.1 2.0 -0.2 -0.5
Glaucoma (self-reported) 0.8 0.9 3.3 0.6 0.3 -1.6 -0.1 0.5 1.0 1.8 -0.2 -0.7 0.0 0.2 -1.8 -1.5 -0.1 0.2 -1.7 -0.1 0.1
Gout (self-reported) 0.5 0.6 2.7 -1.5 0.5 -1.4 0.6 0.3 0.1 1.6 0.2 0.8 0.0 0.8 -0.5 -0.3 0.8 0.8 -0.3 0.6 0.5
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 5.4 -2.3 -0.9 -0.5 0.2 -1.0 -1.5 -0.3 1.5 0.6 0.0 -0.2 -0.1 1.3 -0.2 1.2 1.6 0.1 -0.5
Medication: Amlodipine 0.6 0.8 3.9 1.0 0.3 -0.6 -1.1 -0.2 1.6 0.8 1.3 -0.3 0.0 0.0 -0.9 -2.0 -0.1 -0.6 -1.4 -0.3 -0.8
Medication: Ventolin 100micrograms inhaler 0.4 0.5 3.0 0.8 -0.1 1.0 0.8 0.4 -0.3 0.4 -1.7 -0.7 0.0 0.4 1.3 0.1 0.0 0.6 -0.3 -0.1 0.4
Birth weight 1.1 2.4 8.9 -2.8 -0.9 1.3 1.0 -0.7 -1.1 -1.3 2.2 3.0 0.0 0.8 1.2 1.8 -0.1 1.7 2.3 0.7 -0.9
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.4 1.1 0.6 -0.5 -0.8 -0.2 0.6 -0.3 -0.4 -0.4 0.0 -1.2 -0.1 -0.4 0.2 -0.8 -0.6 -0.3 0.5
High blood pressure (siblings) 0.9 1.3 4.1 -0.6 0.0 0.2 1.5 1.5 1.2 -0.5 -0.4 0.6 0.0 1.1 -1.2 -1.1 2.0 1.2 0.0 1.7 2.0
Forced vital capacity (FVC), Best measure 0.1 0.5 2.7 1.7 -0.5 0.8 -0.1 0.2 0.7 -1.4 -0.9 -0.6 0.0 -0.7 -0.6 -0.2 0.2 -0.5 -0.9 -0.6 0.4
Body fat percentage 0.4 1.5 4.3 1.3 1.4 0.3 -0.8 -1.1 -0.4 1.3 -1.1 -2.1 0.0 -0.8 1.4 -0.4 -1.4 -1.3 -1.7 -1.7 -1.4
Leg fat percentage (right) 0.3 1.2 4.3 1.2 0.7 0.7 -0.6 -0.7 -0.7 0.7 -1.8 -1.6 0.0 -0.7 2.1 0.4 -1.3 -0.8 -1.0 -1.5 -1.1
Arm fat-free mass (right) 1.5 7.9 22.1 -4.7 0.3 1.1 1.9 2.7 2.2 -2.2 3.9 4.7 0.0 4.6 -0.2 -0.5 2.9 1.6 3.5 3.8 1.3
Exposure to tobacco smoke outside home 6.3 8.3 22.8 3.7 1.4 -0.9 -3.5 -3.3 -1.8 2.1 -1.5 -4.8 0.0 -4.2 -1.0 -0.2 -3.1 -3.3 -3.5 -4.1 -3.1
Comparative body size at age 10 1.9 5.2 20.7 -3.4 0.0 1.4 0.2 1.4 2.2 -3.3 4.6 2.9 0.0 2.9 -1.7 -0.7 2.4 -0.4 2.7 2.7 0.9
Number of full brothers 1.7 2.2 8.3 1.2 0.1 -0.1 -0.3 -1.6 -1.8 1.4 -2.0 -2.9 0.0 -1.4 0.2 1.0 -2.2 0.6 -1.5 -2.4 -1.4
Worry too long after embarrassment 1.2 2.0 4.6 -0.9 -1.8 -0.7 2.1 2.1 1.3 0.2 0.3 1.7 0.0 1.3 -0.5 -0.7 2.1 2.1 0.1 2.1 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 2.9 1.4 -0.2 -0.4 -1.5 -0.7 -0.5 -0.0 -0.4 -1.3 0.0 -0.6 0.3 -0.9 -1.7 -1.2 -1.0 -1.4 -1.7
Wheeze or whistling in the chest in last year 0.6 1.0 4.8 0.3 1.6 0.9 -0.5 1.0 2.1 -0.9 0.7 -0.1 0.0 2.2 -0.3 -1.5 0.2 -0.8 0.1 0.5 0.2
Number of children fathered 0.7 0.8 3.3 0.4 1.5 -0.9 -0.7 -0.6 -0.2 0.7 0.8 -1.8 0.0 -0.7 -1.7 -0.6 -0.5 -0.7 -0.7 -0.6 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.9 2.2 5.9 2.4 1.3 -1.4 -2.2 -0.4 0.9 1.0 -0.2 -2.2 0.0 -0.6 -1.6 -1.9 -1.1 -1.8 -2.2 -1.3 -1.1
Age at first live birth 2.3 4.0 13.4 -3.7 -2.8 0.2 0.3 -0.5 -0.9 -1.4 2.8 3.6 0.0 1.3 2.1 2.1 -0.1 1.9 3.3 1.3 -0.9
Pulse wave peak to peak time 0.6 0.8 2.4 -1.1 -1.2 -0.7 0.1 -1.1 -1.4 0.3 -0.3 0.7 0.0 -0.1 1.3 1.5 -0.6 1.2 0.6 -0.3 -0.5
Health satisfaction 1.3 1.6 7.5 0.7 2.7 -0.1 1.0 1.4 2.2 1.0 0.1 -0.7 0.0 1.3 -0.6 -1.7 1.6 -0.8 -1.1 1.0 1.5
Shortness of breath walking on level ground 0.4 0.5 2.1 0.8 1.4 1.1 0.3 0.7 0.6 -0.8 -0.3 -0.9 0.0 0.9 0.1 -0.6 0.5 -1.0 -0.3 -0.0 0.4
Qualifications: College or University degree 7.6 24.0 78.8 -8.5 -3.2 1.7 2.7 3.8 1.8 -4.9 5.9 8.9 0.0 7.0 -0.5 1.3 3.8 4.0 7.6 6.3 2.3
Eye problems/disorders: None of the above 0.9 1.1 4.2 -0.9 -0.9 0.9 0.6 0.2 -1.4 -1.2 -1.6 1.0 0.0 -0.2 1.5 2.0 0.5 0.3 1.3 0.4 0.6
Mouth/teeth dental problems: Loose teeth 0.8 1.0 5.5 0.1 0.3 2.4 1.3 0.3 0.4 -1.6 0.4 0.4 0.0 -0.6 0.7 0.9 1.4 0.7 1.2 0.9 1.4
Emphysema/chronic bronchitis 0.2 0.3 1.4 0.3 -0.9 -0.0 0.3 -0.6 -0.6 0.2 -1.2 -0.4 0.0 -0.5 0.1 0.0 -0.3 0.6 -0.8 -0.4 0.2
Medication for pain relief, constipation, heartburn 0.7 1.3 3.9 -0.1 -0.2 0.4 -1.5 -1.3 -1.7 -2.0 -0.3 0.2 0.0 -1.7 1.1 1.3 -1.1 -1.2 1.0 -1.3 -0.8
Neck or shoulder pain in last month 0.7 1.0 4.4 2.1 0.3 0.6 0.2 0.1 1.2 0.2 -0.7 -2.1 0.0 0.1 -0.8 -1.4 -0.4 -0.5 -1.7 -0.8 -0.1
Medication: Blood pressure 0.5 0.9 3.9 0.6 0.4 -1.5 -0.1 -0.2 1.1 2.0 0.8 -0.4 0.0 -0.7 -0.6 -1.6 0.4 -0.2 -1.8 -0.0 0.3
Angina (self-reported) 0.2 0.3 1.5 0.7 -0.4 -0.1 -0.4 -0.1 0.4 0.3 -0.3 -0.4 0.0 -0.3 -0.5 -1.2 0.2 -0.6 -1.2 -0.3 0.2
Migraine (self-reported) 0.8 1.0 3.9 -0.6 -1.5 1.6 -0.1 0.8 0.4 -2.0 0.7 1.2 0.0 1.8 -0.4 -0.8 0.3 -0.2 1.0 0.7 0.1
Medication: Ibuprofen 2.3 2.8 8.0 -1.6 -0.3 1.6 1.5 2.3 1.6 -0.9 1.8 1.8 0.0 2.8 -1.8 -0.9 1.8 1.0 1.4 2.4 1.5
Medication: Allopurinol 0.4 0.5 1.7 -1.1 -0.6 -1.3 1.0 0.1 -0.1 1.3 -0.4 0.7 0.0 0.1 0.5 0.3 1.2 0.7 -0.1 0.6 0.6
Medication: Omeprazole 1.2 1.4 4.4 -1.2 -0.2 0.1 1.8 1.9 1.1 -0.2 0.0 1.1 0.0 2.1 -0.0 -0.1 1.1 2.0 0.9 1.7 1.3
Medication: Seretide 50 evohaler 0.7 0.8 4.5 -0.0 1.8 2.1 0.9 0.3 0.2 -1.8 0.4 -0.4 0.0 0.2 0.8 1.0 0.4 0.6 0.9 0.1 0.2
Mean time to correctly identify matches 1.4 2.7 9.8 -0.2 -1.9 -3.1 -1.1 -2.1 -2.1 2.5 -0.7 -1.4 0.0 -2.5 -0.7 0.7 -1.5 0.2 -1.1 -1.5 -1.7
Heart disease (mother) 0.8 1.0 3.2 0.2 0.6 -1.0 0.5 1.5 0.7 0.9 -0.7 -1.2 0.0 1.0 -1.6 -1.8 0.8 -0.3 -1.3 0.4 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 5.8 1.8 -0.5 -0.5 -1.1 -1.4 -0.5 0.7 -0.8 -1.7 0.0 -2.4 -0.2 0.1 -1.1 -1.6 -1.4 -1.4 -0.2
Whole body fat mass 0.1 0.5 1.8 -0.2 1.4 0.5 -0.5 -0.5 0.1 0.6 0.3 -0.5 0.0 0.3 1.3 -0.4 -0.6 -0.9 -0.5 -0.6 -1.1
Leg fat mass (right) 0.1 0.4 3.7 -0.3 0.5 0.5 -0.3 -0.6 -0.1 0.4 0.1 -0.2 0.0 0.3 1.9 0.2 -0.7 -0.4 -0.2 -0.6 -1.1
Arm predicted mass (right) 1.3 6.6 20.1 -4.3 0.4 0.9 1.8 2.4 2.0 -2.0 3.5 4.5 0.0 4.1 -0.0 -0.4 2.7 1.5 3.2 3.5 1.3
Pulse rate, automated reading 0.5 1.5 8.7 1.1 -0.8 0.9 2.2 0.4 -0.1 0.5 -2.0 0.3 0.0 -1.2 3.0 0.8 0.9 1.5 -0.3 0.1 1.3
Alcohol intake frequency. 0.5 1.1 3.3 1.1 0.8 0.3 0.7 1.6 1.2 1.3 -0.4 -1.5 0.0 1.4 -1.1 -1.8 -0.1 0.9 -1.3 0.6 0.5
Comparative height size at age 10 0.3 1.7 5.5 -0.3 2.1 0.3 0.0 1.2 2.3 -0.5 1.8 1.2 0.0 1.5 -1.5 -2.3 1.4 -0.3 -0.6 1.2 0.5
Number of full sisters 0.7 0.8 2.5 0.9 0.7 0.9 -1.6 -0.7 0.3 -0.7 1.0 -0.9 0.0 -0.3 -0.7 -0.2 -1.2 -1.5 -0.0 -1.1 -1.5
Suffer from ‘nerves’ 0.5 0.8 2.4 0.1 -0.3 -1.5 1.0 0.4 0.5 1.1 0.0 -1.3 0.0 -0.5 -1.2 -1.1 1.2 0.7 -0.8 0.8 1.0
Overall health rating 2.2 4.7 17.0 3.0 2.8 -2.1 -0.7 0.2 2.6 2.7 -0.6 -2.7 0.0 -0.7 -2.4 -3.6 0.7 -1.7 -4.1 -0.5 0.6
Chest pain or discomfort 1.0 1.4 6.0 0.2 0.3 0.3 -0.6 1.6 2.4 -1.2 1.7 1.8 0.0 1.8 -0.6 -1.1 0.6 -1.4 0.9 1.0 0.1
Had major operations 1.5 1.7 6.6 -2.6 0.2 0.5 0.5 0.6 0.5 -0.8 2.6 1.9 0.0 2.1 0.6 0.1 0.4 0.9 2.0 1.6 -0.2
Age at last live birth 2.0 3.0 9.9 -3.1 -2.3 -0.1 0.3 -1.1 -1.3 -0.7 1.8 2.9 0.0 0.2 2.3 2.5 -0.3 1.8 2.6 0.8 -0.9
Family relationship satisfaction 1.2 1.5 8.3 1.0 1.0 -1.2 -2.9 -1.2 0.6 -0.0 1.5 0.6 0.0 -0.7 -1.0 -1.1 -1.3 -1.6 -0.1 -0.8 -1.9
Leg pain on walking 0.8 1.0 2.8 -0.6 -0.7 -0.2 1.0 -0.8 -1.7 1.4 -1.1 -1.0 0.0 -0.0 1.0 1.7 -1.0 1.7 0.1 -0.8 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 3.9 -1.3 1.3 0.7 2.0 0.5 -0.7 -0.3 -0.1 -0.1 0.0 0.4 0.4 0.7 0.9 1.9 0.9 0.9 1.6
Commuting to job workplace: Car/motor vehicle 1.1 1.2 5.1 -0.8 -0.7 0.9 2.3 1.6 -0.3 0.6 -0.8 0.3 0.0 1.6 1.1 0.4 0.5 2.1 0.8 1.1 0.9
Illness, injury, bereavement, stress in last 2 years 1.1 1.4 5.0 1.8 1.6 -0.7 0.3 -0.3 -0.3 1.8 -1.7 -1.8 0.0 -1.3 0.3 -0.7 0.2 -0.3 -2.2 -0.8 0.8
Medication: Aspirin 1.0 1.3 8.0 -0.1 -1.4 -1.5 1.0 -0.6 -0.1 2.8 -0.8 -1.0 0.0 -0.5 -0.4 -0.5 -0.2 1.8 -1.9 -0.3 0.0
Supplements: Vitamin C 0.2 0.3 1.2 0.4 0.0 -0.7 -0.2 0.3 -0.1 0.9 -1.1 0.0 0.0 0.1 -0.1 -0.4 -0.7 0.2 -1.0 -0.6 -0.3
Knee pain experienced in last month 0.3 0.5 2.3 -0.2 -0.5 0.6 -1.1 -0.9 0.2 -0.2 1.0 -0.3 0.0 0.8 0.0 -0.3 -1.3 -0.6 0.1 -0.8 -1.5
Hypertension (Self-reported) 1.7 4.8 20.8 0.6 1.3 -0.8 1.0 2.5 4.6 0.3 2.3 0.2 0.0 1.7 -3.4 -4.0 2.7 0.2 -1.5 2.2 2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 5.0 -0.2 0.1 0.1 0.5 2.2 1.5 -0.1 0.5 1.2 0.0 1.9 -1.2 -1.3 1.4 -0.0 0.4 1.9 1.0
Illnesses of father: Heart disease 2.7 3.7 12.9 0.6 1.7 1.8 -0.3 2.3 3.6 -2.8 1.6 2.3 0.0 2.0 -1.5 -2.0 2.5 -1.3 1.0 1.9 1.9
Illnesses of siblings: Diabetes 0.4 0.4 1.3 -0.3 -1.1 1.1 0.4 0.8 -0.1 -1.0 -0.4 0.6 0.0 0.0 0.5 0.2 0.7 0.6 0.8 0.6 0.9
Smoking status: Previous 3.0 4.5 12.3 0.8 -0.4 -0.9 -2.5 -3.3 -2.7 1.3 -0.4 -2.2 0.0 -3.0 -0.1 1.1 -3.3 -0.8 -1.3 -3.5 -3.3
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 2.5 -1.6 0.3 -1.1 0.3 -0.5 -0.4 1.0 1.5 0.4 0.0 0.4 0.4 0.8 -0.1 0.4 0.7 0.5 -0.7
Whole body fat-free mass 1.2 7.1 23.6 -4.9 0.4 0.5 1.5 2.1 1.8 -1.8 4.1 4.6 0.0 4.3 -0.2 -0.3 2.4 1.5 3.4 3.6 0.8
Leg fat-free mass (right) 1.0 5.5 19.4 -4.4 1.3 0.2 1.2 1.4 1.7 -1.1 4.4 4.0 0.0 3.5 0.1 -0.4 2.2 0.8 2.8 3.2 0.7
Arm fat percentage (left) 0.2 0.9 2.1 0.4 1.4 0.0 -0.6 -1.1 -0.3 1.3 -0.3 -1.4 0.0 -0.4 1.4 -0.3 -1.0 -0.8 -1.3 -1.2 -1.3
Average weekly red wine intake 1.7 2.5 12.6 -3.5 -1.2 -1.1 1.3 0.9 -0.5 -0.3 1.5 2.6 0.0 1.9 -0.1 0.7 0.9 2.0 2.3 1.9 0.6
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.6 0.3 -0.3 -0.5 -0.0 -0.5 -0.6 -0.2 -1.3 -0.3 0.0 -0.5 0.1 0.7 -0.9 0.9 -0.2 -0.6 0.0
Mood swings 0.4 0.7 2.4 1.4 0.5 1.5 -0.8 -0.6 -0.3 -1.3 -0.5 -0.2 0.0 -0.8 0.6 0.9 -1.0 -0.4 0.1 -0.9 -0.9
Loneliness, isolation 2.9 4.0 10.2 1.0 -0.6 -3.0 -2.6 -3.0 -2.2 2.2 -0.9 -1.1 0.0 -3.2 1.2 0.5 -2.8 -0.8 -1.3 -2.5 -2.6
Long-standing illness, disability or infirmity 0.7 1.1 4.8 0.3 2.2 1.0 -0.6 0.5 1.9 -0.4 1.1 0.0 0.0 1.2 -1.2 -1.9 0.6 -1.2 -0.6 0.4 0.3
Ever had bowel cancer screening 1.3 1.5 6.6 0.2 1.3 -1.7 -0.3 0.6 2.4 0.8 1.5 1.0 0.0 1.1 -1.3 -2.6 0.6 -0.3 -1.1 0.9 0.6
Diabetes diagnosed by doctor 1.0 1.6 6.5 1.4 0.2 -1.1 -1.1 -1.8 0.5 2.6 0.4 -1.3 0.0 -2.1 -0.2 -0.8 -0.8 -1.1 -1.9 -1.3 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 2.7 2.9 11.2 1.5 1.4 -2.1 -1.1 -2.1 -0.3 3.4 -0.4 -1.6 0.0 -1.9 1.2 -0.5 -2.2 -0.6 -2.6 -1.9 -1.6
Friendships satisfaction 0.5 0.7 1.6 0.7 1.2 0.4 -1.1 0.3 1.3 -0.9 0.7 1.2 0.0 0.4 -1.0 -1.2 0.6 -1.1 -0.1 0.6 0.4
Qualifications: nursing, teaching 5.7 8.8 35.3 -4.7 -1.9 2.3 1.5 1.9 0.6 -4.0 3.0 5.9 0.0 3.8 1.0 1.4 2.0 2.1 4.8 3.3 1.2
Commuting to job workplace: Walk 1.6 1.8 5.3 -0.1 -2.3 -0.7 -0.8 -1.8 -1.7 0.2 -1.0 0.8 0.0 -1.4 2.2 1.8 -1.7 0.7 0.4 -1.4 -1.5
Eye problems/disorders: Cataract 0.5 0.6 1.8 0.7 1.3 0.0 -0.3 0.2 0.7 0.7 0.7 -1.4 0.0 -0.0 -1.1 -1.2 -0.1 -0.9 -1.0 -0.2 0.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 6.0 -0.8 0.6 1.0 -0.2 -0.4 0.7 -0.3 2.4 0.4 0.0 0.3 0.8 0.2 0.4 -0.4 1.4 0.7 -0.2
Medication for cholesterol 1.1 1.6 5.8 -1.7 -2.0 -0.6 -0.1 -1.1 -2.2 -0.1 0.1 1.4 0.0 -0.6 1.7 2.4 -1.1 0.7 1.4 -0.3 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.2 5.1 2.2 0.7 2.2 -0.2 -0.1 -0.0 -1.6 -1.6 -1.0 0.0 -0.9 0.9 0.0 0.0 -1.6 -0.4 -1.0 0.2
Back pain experienced in last month 1.5 2.2 5.0 2.2 1.3 -0.5 -1.8 -1.0 -0.3 1.0 -0.9 -2.2 0.0 -1.4 -1.2 -1.2 -1.6 -2.0 -2.2 -1.9 -1.3
Mineral and other dietary supplements 2.9 3.9 9.2 2.1 0.1 -1.1 -1.8 -2.0 -2.1 2.0 -1.9 -3.0 0.0 -2.1 1.6 1.2 -3.0 -0.8 -1.7 -3.0 -2.4
Breast cancer (self-reported) 0.5 0.6 3.2 1.0 0.1 0.2 -0.0 -0.2 1.8 0.5 0.7 -0.2 0.0 0.2 -1.0 -1.6 0.2 0.6 -1.4 -0.1 0.3
Asthma (self-reported) 0.2 0.5 1.8 -0.2 1.3 1.1 0.5 0.8 1.0 -0.9 0.5 0.3 0.0 0.7 0.6 -0.1 0.6 0.3 0.3 0.6 0.7
Osteoporosis (self-reported) 1.1 1.4 4.3 -1.1 -1.8 1.7 0.8 0.3 -0.2 -2.0 0.6 1.8 0.0 0.5 0.8 1.3 0.5 0.9 2.1 0.9 0.5
Osteoarthritis (self-reported) 0.9 1.2 3.1 -1.0 -1.0 1.4 1.3 0.2 -1.5 -1.5 -0.7 1.0 0.0 0.2 1.8 1.5 0.3 1.4 1.2 0.6 0.5
Medication: Aspirin 1.0 1.3 8.5 0.1 -1.5 -1.7 0.7 -0.6 -0.1 2.9 -0.8 -1.0 0.0 -0.6 -0.4 -0.4 -0.6 1.7 -1.7 -0.6 -0.4
Medication: Gliclazide 0.6 0.7 2.2 -0.8 0.4 0.2 0.2 -1.5 -0.6 0.5 1.0 0.9 0.0 -1.1 1.5 1.0 -0.7 1.1 0.4 -0.3 -0.9
Illnesses of father: None of the above (group 1) 0.6 0.7 2.4 -0.9 -0.1 -0.3 0.3 -0.7 -1.3 1.6 -0.0 -0.5 0.0 0.1 0.0 0.6 -1.5 1.3 -0.3 -0.5 -1.5
Smoking status: Current 1.9 3.0 8.8 2.2 0.5 0.3 -1.5 -2.3 -2.0 0.2 -1.5 -1.7 0.0 -3.0 2.2 1.0 -2.1 -1.6 -0.7 -2.4 -1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 4.9 0.7 -1.8 -0.6 0.3 -0.8 -1.1 -0.1 -2.2 -0.9 0.0 -1.9 1.1 1.8 -0.3 0.1 -0.8 -1.0 0.5
Whole body water mass 1.3 7.3 24.2 -4.9 0.5 0.6 1.5 2.2 1.9 -2.0 4.2 4.7 0.0 4.4 -0.2 -0.3 2.5 1.5 3.4 3.6 0.9
Leg predicted mass (right) 1.0 5.5 19.9 -4.5 1.1 0.1 1.2 1.3 1.6 -1.1 4.4 4.0 0.0 3.4 0.1 -0.4 2.2 0.9 2.7 3.1 0.6
Arm fat mass (left) 0.1 0.4 1.5 -1.1 1.2 0.3 -0.2 -0.3 0.3 0.4 1.2 0.3 0.0 0.8 1.1 -0.3 -0.2 -0.5 0.1 0.0 -1.0
Number of self-reported non-cancer illnesses 1.2 2.1 6.0 -1.4 0.5 -0.6 1.5 1.5 2.1 0.9 1.6 0.3 0.0 2.4 -1.7 -1.8 1.8 1.0 0.0 2.2 1.4
Average weekly champagne plus white wine intake 1.7 2.4 5.8 -2.1 -1.0 0.9 1.9 0.9 1.0 -1.5 2.2 2.4 0.0 1.7 0.0 0.3 1.6 1.8 1.8 2.0 1.4
Miserableness 2.1 3.7 8.8 2.2 0.6 -1.5 -2.8 -2.6 -0.9 1.4 0.1 -2.2 0.0 -2.4 -0.9 -0.1 -2.6 -1.9 -2.0 -2.7 -3.0
Guilty feelings 0.8 1.3 4.3 -1.9 -1.8 -0.7 0.9 0.4 -1.1 -0.1 -0.3 1.6 0.0 -0.1 1.2 1.1 0.7 2.1 1.1 1.1 0.6
Wears glasses or contact lenses 2.4 2.7 10.1 -0.1 2.2 1.2 0.8 1.9 3.2 -1.1 1.2 1.4 0.0 1.4 -1.1 -2.3 2.5 -0.5 -0.2 1.6 2.4
Ever taken oral contraceptive pill 0.8 0.9 3.0 -0.4 -1.2 -1.2 -1.3 -1.5 -0.8 0.3 1.5 0.8 0.0 -0.1 0.3 0.6 -1.2 -0.5 0.8 -0.3 -1.7
Hearing aid user 4.5 5.1 11.4 -2.8 -1.8 3.2 2.3 2.0 1.0 -2.4 1.1 2.9 0.0 3.4 1.3 0.5 2.4 2.2 3.0 2.8 2.0
Mother’s age at death 1.3 1.6 5.3 -1.1 -0.5 1.5 -1.7 -0.2 0.4 -2.2 2.3 2.0 0.0 1.1 -0.5 -0.5 -0.8 -1.2 1.5 0.2 -1.4
Financial situation satisfaction 1.4 1.7 4.0 1.2 0.6 0.4 -0.9 -1.7 -1.3 -0.1 -0.7 -1.5 0.0 -1.9 2.0 1.5 -1.8 -0.4 -0.0 -2.0 -1.8
Tinnitus: Yes, now most or all of the time 2.3 2.6 8.5 1.7 -1.1 -0.6 -0.1 -1.8 -2.1 1.2 -2.9 -2.7 0.0 -2.6 1.1 0.9 -1.4 0.0 -1.8 -1.9 -0.3
Commuting to job workplace: Public transport 1.4 1.7 6.3 -2.1 -0.2 -0.4 -0.5 0.4 1.2 -1.1 2.5 2.5 0.0 1.5 -1.2 -0.8 1.4 -0.4 1.1 1.7 0.4
Eye problems/disorders: Glaucoma 0.6 0.7 3.0 1.1 0.0 -0.9 -0.4 0.1 0.9 1.4 0.1 -0.8 0.0 -0.3 -1.7 -1.1 -0.5 0.1 -1.6 -0.7 -0.3
Medication: Blood pressure 0.9 1.7 6.2 0.0 0.7 0.1 0.9 1.7 2.5 -0.7 0.7 0.5 0.0 1.0 -1.4 -1.9 2.2 0.3 -0.0 1.8 2.1
Pain type(s) experienced in last month: Hip pain 1.5 1.8 4.8 2.1 2.0 0.1 -1.7 -0.5 0.6 1.0 -0.1 -2.1 0.0 -0.8 -1.0 -1.3 -1.3 -2.2 -1.6 -1.4 -1.1
Supplements: Fish oil (including cod liver oil) 2.6 3.4 8.0 -1.8 -0.2 0.7 2.1 2.2 2.1 -1.4 1.5 2.7 0.0 2.4 -0.9 -1.5 2.8 1.4 1.2 2.7 2.2
High cholesterol (Self-reported) 0.8 1.4 5.7 1.9 0.6 -0.2 -0.3 0.6 1.3 1.2 -1.0 -1.6 0.0 0.2 -1.7 -2.4 0.1 -0.2 -2.2 -0.3 0.3
Medication: Bendroflumethiazide 0.4 0.7 2.3 1.1 0.5 1.1 0.5 1.1 0.9 -1.5 -0.7 -0.7 0.0 0.4 -0.3 -1.3 0.3 -0.3 -0.8 0.1 0.9
Medication: Paracetamol 0.2 0.2 1.4 0.6 0.3 0.1 0.5 0.5 -0.0 1.2 -0.4 -1.0 0.0 0.4 0.3 -0.1 0.1 -0.3 -0.4 0.1 -0.6
Medication: Lisinopril 0.4 0.5 2.5 -0.1 -1.5 -0.2 -0.9 -0.8 0.3 0.0 1.6 0.4 0.0 -0.7 -0.4 -0.3 -0.6 -0.2 0.0 -0.1 -0.9
Medication: Atorvastatin 0.1 0.2 0.9 -0.3 0.2 0.5 0.7 -0.5 -0.2 -0.2 -0.0 0.3 0.0 0.1 0.9 0.6 -0.1 0.3 0.3 0.0 0.0
Illnesses of father: High blood pressure 2.0 2.5 6.9 -1.1 -0.8 -0.2 0.9 1.8 2.4 -1.2 1.9 1.2 0.0 2.3 -2.6 -1.3 2.1 0.0 0.8 2.0 1.9
Alcohol drinker status: Never 1.1 1.3 3.7 -0.4 -0.2 -0.6 1.0 1.5 1.7 1.8 0.7 -0.2 0.0 1.9 -1.1 -1.8 0.5 1.5 -0.8 1.1 0.6
Ever smoked 3.7 6.5 20.9 2.0 -0.8 -0.3 -2.5 -4.0 -3.4 1.0 -1.5 -2.9 0.0 -4.6 0.8 1.2 -3.3 -1.2 -1.9 -4.2 -3.4
Basal metabolic rate 1.0 5.4 17.9 -4.2 0.7 0.7 1.2 1.8 1.7 -1.6 3.7 4.0 0.0 3.9 0.1 -0.4 2.0 1.0 2.9 3.0 0.5
Leg fat percentage (left) 0.3 1.1 2.8 1.2 0.8 0.6 -0.8 -0.9 -0.3 0.8 -1.1 -1.7 0.0 -0.7 1.6 -0.1 -1.2 -1.1 -1.2 -1.5 -1.2
Arm fat-free mass (left) 1.2 6.3 18.7 -4.3 0.2 1.1 1.4 2.2 1.9 -2.3 3.6 4.3 0.0 4.1 -0.1 -0.3 2.3 1.1 3.4 3.2 0.8
Number of operations (self-reported) 2.7 4.0 10.9 -3.3 0.0 2.4 2.1 1.1 0.9 -2.2 2.8 2.2 0.0 2.8 0.5 0.7 1.7 1.8 3.0 2.6 1.0
Average weekly beer plus cider intake 4.1 5.9 13.9 3.1 2.4 -0.7 -2.6 -2.6 -1.5 2.8 -1.9 -3.7 0.0 -3.3 0.8 0.7 -2.8 -2.4 -2.5 -3.3 -2.5
Irritability 0.1 0.2 1.3 0.7 0.3 0.4 -0.1 -0.1 0.0 -1.0 -0.1 0.4 0.0 -0.4 1.1 0.5 0.4 -0.3 0.4 -0.4 -0.1
Risk taking 0.3 0.4 4.2 -0.4 2.0 -0.5 0.6 0.1 0.2 0.9 0.6 -0.7 0.0 0.3 -0.2 -0.5 0.2 0.3 -0.6 0.2 0.1
Ever had prostate specific antigen (PSA) test 2.2 2.5 8.7 -1.1 1.5 -0.9 -0.1 1.2 2.4 -0.5 3.0 1.0 0.0 1.9 -2.6 -2.9 1.4 0.1 0.2 1.8 0.6
Fractured/broken bones in last 5 years 4.5 5.8 11.7 -2.5 -0.4 2.8 2.6 2.6 2.0 -2.8 2.2 3.4 0.0 2.5 1.3 0.4 3.2 1.4 3.0 3.2 2.8
Age started oral contraceptive pill 0.4 0.5 2.0 -1.2 -1.2 -0.3 -0.0 -0.3 -0.3 0.0 0.9 0.8 0.0 1.0 0.0 0.2 -0.7 0.6 0.5 0.0 -1.4
Diastolic blood pressure, automated reading 0.4 1.4 6.1 1.7 -0.4 2.5 0.1 0.3 1.3 -2.3 -0.3 0.7 0.0 -1.1 1.1 -0.6 1.2 -1.5 0.0 -0.0 1.3
Ever depressed for a whole week 0.3 0.4 2.1 -0.7 -0.8 -0.9 -0.4 -0.3 -0.3 -0.0 1.5 1.1 0.0 -0.2 -0.6 -0.0 0.1 -0.1 0.4 0.2 -0.7
Unable to work because of sickness or disability 5.1 6.6 16.3 4.0 -0.3 -0.9 -2.4 -3.0 -2.1 2.1 -3.1 -3.3 0.0 -4.0 0.8 0.2 -2.8 -2.2 -3.2 -3.6 -2.2
Commuting to job workplace: Cycle 2.9 3.5 13.2 -3.6 -2.1 1.4 1.7 0.6 -1.0 -1.2 1.3 2.8 0.0 1.9 1.7 2.1 0.7 2.6 2.8 1.6 0.6
Myopia 0.6 0.8 2.9 -1.7 0.9 -0.4 1.1 0.3 0.5 -0.2 1.1 1.1 0.0 0.4 -0.6 -0.2 1.1 1.2 0.1 1.3 1.4
Vascular/heart problems diagnosed by doctor 1.3 3.5 15.1 -0.9 -1.1 0.2 -1.0 -2.0 -3.9 -0.5 -1.5 0.4 0.0 -1.0 2.7 3.5 -2.4 0.0 1.7 -1.6 -2.4
Cholesterol lowering medication 1.4 2.0 5.7 2.2 1.5 -0.5 -0.1 0.9 2.3 1.5 -1.1 -1.7 0.0 0.1 -2.1 -2.4 0.6 -0.6 -2.3 -0.1 0.9
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.1 -1.1 0.2 -0.7 1.4 1.2 1.0 0.9 0.4 0.8 0.0 1.7 -0.7 -0.6 0.8 1.8 0.2 1.4 0.9
Pain experienced in last month 0.5 0.9 4.5 -1.3 0.5 -0.0 -0.0 -0.3 -0.1 -0.9 1.2 2.1 0.0 -0.2 1.3 1.4 0.7 -0.0 1.7 0.7 0.3
Supplements: Calcium 2.3 2.5 8.6 -2.4 -0.4 0.9 0.4 1.1 1.3 -1.9 2.9 2.4 0.0 2.0 -1.3 -0.6 1.2 0.3 2.2 2.1 0.3
Basal cell carcinoma (self-reported) 0.8 0.9 4.2 -0.6 -2.1 -0.7 -0.6 -1.1 -1.5 0.0 -0.1 -0.3 0.0 -0.2 -0.0 1.1 -1.6 0.7 0.4 -0.9 -1.5
Heart attack/myocardial infarction (self-reported) 0.3 0.3 1.5 0.1 -0.4 0.9 0.7 0.2 0.9 -0.4 0.4 1.2 0.0 -0.0 0.6 0.1 0.6 0.7 0.4 0.5 0.7
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.9 -0.2 1.1 1.4 -0.0 0.3 -0.4 -0.9 0.3 0.2 0.0 0.6 1.1 1.0 -0.6 0.0 0.8 -0.3 -0.7
Heart disease (siblings) 0.5 0.6 2.0 0.3 1.2 -1.2 0.2 0.4 1.2 1.4 0.4 -0.0 0.0 -0.2 0.2 -1.2 0.8 0.2 -1.0 0.6 0.9
Alcohol drinker status: Previous 0.4 0.4 1.4 -0.2 0.2 -0.1 1.1 0.9 -0.4 0.3 -1.1 -1.0 0.0 0.4 -0.5 0.2 0.5 0.6 0.0 0.8 1.2
Pack years of smoking 1.5 2.2 9.5 1.1 1.6 -0.1 0.2 1.8 3.1 0.1 0.2 0.1 0.0 1.3 -2.4 -3.0 1.6 -0.4 -1.2 1.1 1.3
Impedance of whole body 1.5 7.6 27.0 5.2 0.5 -1.5 -1.8 -1.3 -0.7 2.8 -3.7 -4.9 0.0 -3.2 -1.6 -1.7 -2.4 -1.9 -4.5 -3.3 -1.2
Leg fat mass (left) 0.1 0.4 2.4 -0.4 0.6 0.4 -0.5 -0.7 0.3 0.4 0.7 -0.1 0.0 0.4 1.6 -0.1 -0.6 -0.6 -0.1 -0.4 -1.1
Arm predicted mass (left) 1.2 6.0 19.4 -4.2 0.3 1.0 1.1 2.0 1.8 -2.1 3.8 4.4 0.0 3.9 -0.0 -0.2 2.1 0.9 3.4 3.1 0.5