TWAS hub - ERCC8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1070	0.0340	6.5e-11	0.080	0.087	0.086	0.092	0.096	5.9e-10	9.4e-11	1.1e-10	2.7e-11	8.9e-12
2	GTEx	Adipose Visceral Omentum	0.2150	0.0890	7.0e-03	-0.005	NA	0.026	NA	-0.002	6.9e-01	NA	1.7e-02	NA	4.4e-01
3	GTEx	Artery Tibial	0.0919	0.0408	3.6e-03	0.008	NA	-0.001	NA	0.001	7.5e-02	NA	4.0e-01	NA	2.4e-01
4	GTEx	Cells Transformed fibroblasts	0.0840	0.0310	8.4e-05	0.041	NA	0.029	NA	0.048	4.9e-04	NA	2.7e-03	NA	1.7e-04
5	GTEx	Esophagus Mucosa	0.1580	0.0570	2.0e-05	0.055	NA	0.090	NA	-0.002	1.4e-04	NA	1.3e-06	NA	4.7e-01
6	GTEx	Thyroid	0.1270	0.0380	2.1e-09	0.190	NA	0.141	NA	0.172	1.7e-14	NA	6.2e-11	NA	3.4e-13
7	METSIM	Adipose	0.0652	0.0205	1.6e-10	0.077	0.078	0.066	0.076	0.053	1.2e-11	8.9e-12	3.5e-10	1.6e-11	2.1e-08
8	YFS	Blood	0.0148	0.0066	3.4e-04	0.007	0.011	0.006	0.010	0.007	1.5e-03	8.5e-05	2.9e-03	1.7e-04	1.6e-03
9	TCGA	Breast Invasive Carcinoma	0.0864	0.0316	2.6e-11	0.061	0.053	0.063	NA	0.032	1.9e-12	3.9e-11	8.5e-13	NA	2.8e-07
10	TCGA	Colon Adenocarcinoma	0.0870	0.0480	5.6e-04	0.086	0.072	0.077	NA	0.081	1.2e-05	5.7e-05	3.0e-05	NA	2.1e-05
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0323	0.0199	1.5e-03	0.012	0.021	0.024	NA	0.015	1.4e-02	1.8e-03	9.2e-04	NA	7.9e-03
12	TCGA	Kidney Renal Clear Cell Carcinoma	0.0678	0.0464	5.3e-04	0.043	0.032	0.015	NA	0.037	1.1e-05	1.4e-04	7.6e-03	NA	4.7e-05
13	TCGA	Brain Lower Grade Glioma	0.0857	0.0424	1.5e-04	0.037	0.015	0.007	NA	0.014	4.1e-05	6.2e-03	4.9e-02	NA	9.0e-03
14	TCGA	Lung Adenocarcinoma	0.0433	0.0276	3.4e-03	0.009	0.014	0.011	NA	0.009	2.9e-02	8.2e-03	1.6e-02	NA	2.7e-02
15	TCGA	Lung Squamous Cell Carcinoma	0.0569	0.0399	1.3e-03	0.032	0.029	0.016	NA	0.028	1.4e-04	2.9e-04	5.1e-03	NA	3.3e-04
16	TCGA	Pancreatic Adenocarcinoma	0.1090	0.0600	5.3e-04	0.074	0.079	0.085	NA	0.082	5.2e-04	3.4e-04	2.0e-04	NA	2.5e-04
17	TCGA	Prostate Adenocarcinoma	0.0650	0.0401	8.7e-04	0.038	0.014	0.016	NA	0.021	7.3e-05	1.1e-02	8.3e-03	NA	2.3e-03
18	TCGA	Thyroid Carcinoma	0.1080	0.0490	4.1e-05	0.026	0.043	0.040	NA	0.033	1.4e-03	4.3e-05	8.8e-05	NA	3.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Qualifications: None of the above	18.5	39.7	71.2	5.5	3.6	5.8	7.3	7.3	4.9	6.8	1.5	7.4	4.3	7.1	8.2	2.5	8.0	6.8	6.3	8.4	6.3
Qualifications: College or University degree	13.9	43.9	75.4	-4.8	-3.0	-6.0	-8.0	-8.3	-3.3	-6.9	-3.1	-7.8	-5.6	-7.7	-8.5	-1.7	-8.7	-7.6	-7.2	-8.5	-6.1
Qualifications: nursing, teaching	10.8	16.7	26.9	-3.8	-3.4	-4.9	-4.6	-5.0	-2.3	-4.1	-1.1	-5.1	-2.8	-4.0	-5.1	-2.0	-5.1	-4.3	-3.8	-5.2	-4.0
Qualifications: A levels/AS levels or equivalent	8.8	19.4	33.7	-3.3	-2.1	-4.1	-5.4	-5.8	-2.2	-4.3	-1.8	-5.1	-3.7	-4.9	-5.6	-1.1	-5.8	-5.1	-4.9	-5.6	-4.0
Fractured/broken bones in last 5 years	8.4	10.8	16.7	-2.1	-2.1	-3.5	-3.8	-3.6	-0.6	-3.6	-2.1	-4.0	-3.6	-2.8	-3.6	-2.4	-4.0	-4.1	-3.7	-3.3	-3.9
Hearing aid user	8.3	9.4	20.7	-2.9	-3.5	-3.1	-3.1	-2.7	-1.6	-4.5	-1.8	-3.6	-2.4	-3.2	-3.2	-2.0	-3.7	-3.2	-2.7	-3.2	-3.2
Smoking Status	7.7	18.4	34.5	-0.5	3.4	1.7	5.5	4.7	-0.8	4.3	4.9	4.2	5.7	4.5	5.0	-0.1	5.4	5.5	5.9	4.6	3.5
Schizophrenia (2018)	7.6	15.7	34.0	3.5	4.4	3.4	4.2	4.1	2.2	5.8	1.6	4.4	3.1	4.1	4.5	2.2	4.6	4.3	3.8	4.5	4.2
Alcohol usually taken with meals	7.6	12.3	20.6	-1.5	-2.2	-2.2	-4.5	-4.3	-1.2	-3.9	-2.5	-3.8	-3.5	-3.9	-4.4	-0.7	-4.4	-4.2	-4.2	-4.3	-3.3
Unable to work because of sickness or disability	7.6	9.8	17.7	1.6	1.5	2.0	3.9	4.0	1.1	3.5	2.1	3.3	3.6	3.1	3.7	0.9	4.2	4.2	3.9	3.5	3.1
Exposure to tobacco smoke outside home	7.2	9.6	18.7	1.4	1.5	2.0	4.3	3.7	1.2	3.4	1.4	3.5	2.9	3.1	4.3	0.7	3.9	3.5	3.7	4.3	3.0
Schizophrenia (2014)	6.7	14.7	40.4	3.4	4.7	2.4	3.9	3.5	2.6	6.4	1.8	3.8	3.0	4.6	4.2	2.0	4.2	4.1	3.7	4.2	4.1
Multivitamins +/- minerals	6.0	7.6	14.4	0.0	-1.8	-1.3	-3.8	-3.7	1.0	-3.5	-2.5	-2.8	-3.5	-2.3	-3.3	-0.1	-3.0	-3.3	-3.7	-3.1	-2.3
Number of operations (self-reported)	6.0	8.9	18.4	-2.5	-2.6	-2.3	-3.0	-3.0	-1.4	-4.3	-1.6	-3.3	-2.8	-3.6	-3.3	-1.5	-3.6	-3.6	-3.1	-3.2	-3.1
Qualifications: O levels/GCSEs or equivalent	5.5	8.8	17.8	-3.3	-1.0	-2.5	-3.1	-3.4	-3.4	-3.5	-0.3	-3.3	-1.1	-4.2	-3.8	-1.0	-3.5	-2.7	-2.4	-4.0	-2.8
Bipolar Disorder or Schizophrenia	5.2	12.6	32.9	3.5	4.4	2.6	3.5	3.5	2.4	5.7	1.4	3.7	2.5	4.0	3.9	1.9	3.9	3.7	3.2	3.9	3.7
Average weekly beer plus cider intake	5.1	7.4	14.1	0.4	1.0	2.3	3.7	3.2	-0.4	3.4	2.6	2.9	2.9	2.7	3.4	-0.7	3.8	3.0	3.3	3.3	1.5
Ever smoked	4.9	8.5	16.0	-0.6	1.7	0.3	3.7	3.1	-0.6	3.4	3.8	2.5	3.8	3.5	3.5	-0.8	3.4	3.5	4.0	3.2	2.0
Mineral and other dietary supplements	4.7	6.3	10.6	0.2	2.8	1.8	3.1	3.2	-1.0	3.3	2.9	2.5	3.1	1.8	2.7	0.2	2.9	2.9	3.2	2.4	1.9
Commuting to job workplace: Cycle	4.7	5.7	9.5	-3.1	-2.7	-2.8	-2.2	-2.2	-2.9	-2.5	0.7	-2.5	-0.9	-2.4	-2.7	-1.7	-2.8	-2.2	-1.8	-2.9	-2.6
Supplements: Calcium	4.6	5.0	11.0	-1.3	-0.7	-1.8	-2.7	-3.3	-0.2	-2.2	-1.6	-2.6	-2.4	-2.4	-2.7	-0.5	-2.7	-2.7	-2.7	-2.6	-2.0
Past tobacco smoking	4.4	8.1	16.1	0.6	-1.2	-0.5	-3.5	-2.9	0.9	-3.2	-3.8	-2.7	-3.8	-3.3	-3.4	0.7	-3.5	-3.5	-4.0	-3.1	-2.0
Comparative body size at age 10	4.2	11.5	22.0	-2.0	-0.6	-3.5	-3.7	-4.5	0.6	-4.7	-3.9	-3.6	-4.1	-2.7	-3.3	-0.5	-4.7	-4.4	-4.0	-3.0	-2.5
Intelligence (Savage-Jansen 2018)	4.1	12.7	22.0	-3.4	-0.8	-3.7	-4.1	-4.2	-2.4	-3.8	-0.2	-4.3	-2.6	-4.1	-4.5	-1.6	-4.7	-3.8	-3.6	-4.6	-3.6
Mouth/teeth dental problems	4.0	6.1	11.9	-3.0	0.0	-2.8	-2.7	-3.5	-2.8	-2.3	0.7	-2.7	-1.0	-2.1	-3.1	-1.5	-2.8	-2.3	-2.0	-3.3	-2.7
Verbal and Numeric Reasoning (VNR)	3.8	9.1	16.4	-2.7	-0.6	-2.3	-3.4	-3.5	-2.0	-3.4	-0.5	-3.5	-2.3	-4.0	-4.0	-1.1	-3.8	-3.3	-3.1	-4.0	-3.0
Exposure to tobacco smoke at home	3.7	4.1	8.9	1.0	1.6	1.9	2.4	1.8	0.0	2.4	1.6	2.3	2.4	2.1	2.2	0.4	3.0	2.5	2.4	2.1	1.8
Number of full brothers	3.7	4.6	8.7	0.1	1.7	2.4	2.8	2.8	-0.7	1.3	2.5	2.4	2.7	1.0	2.4	0.4	3.0	2.7	2.7	2.2	1.6
Ever had stillbirth, spontaneous miscarriage or termination	3.7	3.9	8.4	1.8	0.7	2.2	2.2	1.5	0.8	2.1	1.2	2.9	1.2	2.6	2.4	1.7	2.4	1.9	1.6	2.4	2.3
Alzheimer’s Disease (including proxy)	3.5	5.1	11.3	1.8	1.4	1.9	2.7	2.3	1.5	2.1	0.4	2.6	1.8	3.4	2.8	0.9	2.9	2.4	2.3	2.8	2.3
Smoking status: Previous	3.5	5.2	9.9	-0.5	1.3	0.8	2.7	2.1	-0.8	2.4	3.1	2.3	3.0	2.5	2.7	-0.1	2.9	2.7	3.1	2.4	1.9
Bilateral oophorectomy (both ovaries removed)	3.4	3.9	6.6	1.4	1.3	1.9	2.2	1.9	0.3	2.4	1.1	2.6	2.0	1.9	2.4	1.6	2.3	2.2	2.0	2.3	2.3
Age at first live birth	3.4	6.0	11.6	-3.1	-1.2	-2.6	-2.8	-3.4	-2.2	-2.4	0.2	-2.8	-1.2	-2.4	-3.1	-0.8	-3.0	-2.4	-2.1	-3.3	-2.1
Illnesses of father: Heart disease	3.4	4.6	13.4	0.3	-0.3	-2.3	-2.6	-2.5	2.4	-1.8	-3.7	-2.5	-3.1	-0.6	-1.8	-0.8	-2.4	-2.5	-2.5	-1.5	-1.5
Qualifications: CSEs or equivalent	3.3	4.3	9.5	0.2	1.8	1.2	3.0	3.1	-0.1	1.8	1.3	2.3	2.4	1.7	2.6	0.7	2.4	2.6	2.6	2.4	2.0
Mouth/teeth dental problems: Dentures	3.3	5.6	10.9	2.6	0.2	2.0	2.7	3.3	2.6	2.0	-0.4	2.5	1.4	2.4	3.0	1.0	2.9	2.6	2.3	3.2	2.4
Medication: Ibuprofen	3.3	3.9	6.4	-1.0	-1.4	-1.0	-2.3	-2.5	-0.2	-2.3	-1.6	-2.3	-2.1	-2.4	-2.4	-0.4	-2.5	-2.4	-2.4	-2.3	-1.8
Wears glasses or contact lenses	3.3	3.7	13.1	0.9	-3.6	-1.7	-1.9	-1.8	2.2	-1.7	-3.0	-1.0	-3.1	0.6	-0.6	-0.2	-2.1	-2.3	-2.3	-0.0	-0.9
Impedance of arm (right)	3.2	14.8	25.8	3.2	1.9	3.3	4.3	4.6	1.7	5.1	2.2	4.4	3.5	4.2	4.6	1.5	4.9	4.5	4.1	4.5	3.8
Overall health rating	3.2	6.8	19.5	4.4	0.9	3.8	1.4	1.8	4.2	1.9	-1.9	3.0	-0.3	1.8	2.6	3.2	2.5	1.6	0.6	3.0	3.1
Loneliness, isolation	3.2	4.4	10.9	0.9	1.7	1.2	2.3	1.9	0.1	3.3	2.3	2.3	2.6	2.3	2.0	1.5	2.3	2.6	2.3	1.7	2.5
Average weekly champagne plus white wine intake	3.2	4.4	7.5	-0.6	-1.7	-1.2	-2.6	-2.6	0.1	-2.7	-1.5	-2.3	-2.4	-2.2	-2.6	-0.4	-2.4	-2.6	-2.6	-2.4	-1.9
Impedance of whole body	3.2	16.2	31.7	3.6	2.6	3.6	4.3	5.0	1.9	5.6	2.3	4.3	3.6	4.4	4.6	1.3	5.2	4.7	4.3	4.5	3.7
Diverticular disease/diverticulitis (self-reported)	3.1	3.6	6.0	1.7	2.3	2.1	2.1	1.6	0.7	2.4	1.1	2.4	1.5	1.7	1.9	2.0	1.9	1.9	1.5	1.9	2.5
Had other major operations	3.1	3.8	5.9	-0.9	-1.5	-2.0	-2.2	-2.1	0.3	-2.1	-1.5	-2.4	-2.4	-1.9	-2.2	-0.9	-2.4	-2.4	-2.3	-2.0	-2.0
Had major operations	3.0	3.5	7.6	-1.6	-0.3	-1.2	-2.0	-2.2	-1.1	-2.8	-1.0	-1.9	-1.7	-2.6	-2.2	-0.2	-2.4	-2.3	-2.1	-2.1	-1.5
Tinnitus: Yes, now most or all of the time	3.0	3.5	9.7	0.2	-0.1	1.1	2.7	3.1	-0.4	1.8	2.0	1.9	2.4	1.2	2.2	0.0	2.3	2.4	2.4	2.0	1.4
Illnesses of father: High blood pressure	3.0	3.7	11.4	0.9	-1.1	0.2	-2.2	-2.2	1.3	-2.4	-3.4	-1.3	-2.8	-1.9	-1.7	1.1	-2.2	-2.4	-2.6	-1.3	-0.6
Ulcerative Colitis (UC)	2.9	5.4	12.0	-1.9	-1.0	-1.8	-2.8	-2.1	-1.1	-3.2	-1.4	-2.7	-1.9	-3.5	-2.8	-0.8	-2.9	-2.4	-2.4	-2.9	-2.3
Supplements: Glucosamine	2.9	3.7	7.4	-1.2	-2.1	-1.7	-2.5	-2.1	-0.6	-2.6	-0.8	-2.2	-1.3	-2.2	-2.6	-0.3	-2.2	-1.7	-2.0	-2.7	-1.6
Length of working week for main job	2.9	3.2	5.2	-1.2	-1.4	-0.7	-1.9	-1.9	-1.0	-2.3	-1.6	-1.7	-2.0	-2.2	-1.9	-0.8	-2.2	-2.3	-2.0	-1.8	-2.1
Commuting to job workplace: Public transport	2.9	3.4	7.6	-0.4	-1.3	-1.6	-2.3	-2.8	0.4	-1.8	-2.0	-1.9	-2.3	-1.5	-2.1	0.1	-2.4	-2.4	-2.4	-1.9	-1.1
Townsend deprivation index at recruitment	2.8	3.9	7.5	-0.0	0.3	0.0	2.6	2.7	0.1	2.2	2.2	1.7	2.5	2.2	2.4	-0.5	2.3	2.6	2.7	2.2	1.4
Supplements: Fish oil (including cod liver oil)	2.8	3.6	7.3	0.1	-1.9	-1.1	-2.7	-2.4	1.0	-2.5	-2.1	-1.8	-2.4	-1.3	-2.1	0.3	-2.2	-2.1	-2.5	-1.9	-1.2
Waist Hip Ratio (WHR)	2.7	12.1	23.7	3.7	2.0	3.6	3.6	3.5	2.3	4.9	1.4	4.0	2.5	3.8	4.1	1.6	4.5	3.8	3.4	4.2	3.4
Current tobacco smoking	2.7	4.5	8.4	-0.8	1.6	-0.2	2.9	2.5	-0.8	2.4	2.6	1.6	2.7	2.4	2.5	-1.2	2.4	2.5	2.8	2.3	0.9
Frequency of tenseness / restlessness in last 2 weeks	2.7	4.2	9.5	3.1	1.1	2.4	1.8	1.2	2.5	3.0	-0.3	2.5	0.4	2.1	2.1	2.2	2.1	1.5	1.0	2.4	2.4
Fluid intelligence score	2.7	5.6	11.8	-1.9	0.2	-1.7	-3.1	-2.8	-1.3	-2.1	0.0	-2.9	-1.8	-3.1	-3.4	-0.5	-3.0	-2.5	-2.5	-3.4	-2.2
Father’s age at death	2.7	3.6	7.7	-0.1	-0.4	-0.5	-2.8	-2.8	-0.2	-1.4	-1.2	-1.8	-2.2	-2.0	-2.6	0.3	-2.3	-2.4	-2.7	-2.5	-1.5
Impedance of leg (right)	2.6	12.6	27.2	2.4	2.8	2.5	3.9	5.0	0.7	5.2	2.6	3.3	4.0	3.4	3.8	0.2	4.5	4.5	4.3	3.5	2.8
Arm fat-free mass (right)	2.6	13.5	27.7	-2.1	-2.1	-2.4	-4.4	-4.9	-0.8	-5.3	-2.9	-3.7	-3.9	-3.8	-4.3	-0.2	-4.8	-4.5	-4.4	-4.2	-2.9
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.1	7.7	2.0	2.8	2.1	1.3	1.4	2.1	2.5	0.1	1.8	0.6	1.2	1.8	1.6	1.9	1.4	1.1	1.9	2.1
Ever had prostate specific antigen (PSA) test	2.6	3.0	7.0	1.0	0.7	-0.0	-1.9	-2.1	1.9	-1.3	-2.6	-1.0	-2.7	-1.7	-1.4	1.8	-2.0	-2.1	-2.4	-1.1	0.1
Vitamin and mineral supplements	2.5	3.4	7.2	-0.4	1.4	0.9	2.7	2.6	-0.9	2.2	1.7	1.8	2.4	1.1	2.2	0.1	1.9	2.2	2.5	2.0	1.5
Fed-up feelings	2.5	4.6	9.5	1.4	2.7	1.5	2.4	2.0	1.2	3.1	1.0	2.5	1.7	1.8	2.5	1.5	2.3	2.3	2.2	2.5	2.6
Impedance of leg (left)	2.5	12.2	26.5	2.7	3.2	2.7	3.7	4.5	1.2	5.2	2.1	3.4	3.5	3.6	3.9	0.4	4.5	4.3	4.0	3.7	2.9
Trunk fat-free mass	2.5	14.1	25.9	-2.3	-1.7	-2.6	-4.4	-5.1	-1.2	-5.1	-2.7	-3.8	-3.7	-4.0	-4.6	0.1	-5.0	-4.5	-4.5	-4.5	-2.8
Falls in the last year	2.5	3.5	9.4	0.6	-2.0	-0.3	-1.8	-2.1	1.9	-3.0	-3.1	-1.0	-2.8	-1.0	-1.2	1.2	-2.0	-2.3	-2.5	-0.8	-0.3
Age at last live birth	2.5	3.7	7.5	-2.7	-0.5	-2.2	-2.1	-2.6	-2.1	-1.4	1.0	-2.2	-0.6	-1.6	-2.5	-1.0	-2.1	-1.7	-1.4	-2.7	-1.8
Schizophrenia vs Biploar Disorder	2.4	3.2	5.3	1.1	1.9	1.9	2.3	1.8	0.6	1.9	0.7	2.1	1.5	1.7	2.2	0.9	2.0	1.9	1.9	2.2	2.0
Fasting Glucose	2.4	2.9	8.5	1.6	0.3	1.1	1.9	1.0	1.4	1.8	0.0	2.2	1.3	2.9	2.4	0.6	1.6	1.8	1.4	2.5	1.8
Allergy or Eczema	2.4	6.2	10.6	-0.1	-2.6	-1.9	-3.1	-2.7	0.5	-2.6	-2.2	-2.8	-3.0	-2.0	-3.1	-0.4	-3.1	-3.0	-3.2	-2.9	-2.2
Alcohol intake versus 10 years previously	2.4	3.5	7.8	1.8	1.1	1.8	2.2	1.6	0.8	2.8	0.8	2.2	1.6	2.4	2.1	1.0	2.3	2.0	1.8	2.0	2.0
Impedance of arm (left)	2.4	11.0	19.4	3.4	1.6	3.3	3.5	3.9	1.8	4.4	1.7	3.9	2.6	3.5	3.9	1.7	4.2	3.7	3.2	3.9	3.4
Trunk predicted mass	2.4	13.9	25.6	-2.3	-1.6	-2.6	-4.4	-5.1	-1.1	-5.0	-2.7	-3.8	-3.7	-4.0	-4.6	0.1	-5.0	-4.4	-4.4	-4.5	-2.7
Back pain experienced in last month	2.4	3.5	6.2	1.1	2.5	1.1	2.3	1.9	1.0	2.5	1.2	1.9	1.4	2.1	2.3	0.1	2.3	1.9	1.9	2.4	1.4
Osteoporosis (self-reported)	2.4	2.9	11.9	-1.3	-3.5	-1.8	-1.7	-1.5	-0.9	-1.8	-0.8	-2.0	-0.9	-1.7	-1.9	-1.1	-1.8	-1.5	-1.1	-2.0	-1.6
Medication: Ibuprofen (e.g. Nurofen)	2.3	3.0	6.0	0.1	-0.9	-0.1	-2.1	-2.4	0.9	-1.9	-1.9	-1.7	-2.4	-1.9	-1.9	0.2	-2.0	-2.2	-2.4	-1.7	-1.2
Medication: Lansoprazole	2.3	2.6	4.3	1.5	1.6	1.8	1.8	2.0	0.9	1.8	0.5	1.7	1.6	1.2	1.5	1.2	2.0	2.1	1.8	1.4	1.9
Whole body water mass	2.3	13.1	26.9	-2.2	-2.0	-2.5	-4.2	-4.9	-0.9	-5.2	-2.8	-3.5	-3.8	-3.8	-4.2	0.1	-4.8	-4.4	-4.3	-4.1	-2.7
Miserableness	2.3	4.1	9.1	1.1	3.0	1.4	2.4	1.5	1.1	2.7	1.2	2.1	1.8	1.9	2.2	1.0	2.5	2.2	2.2	2.1	2.2
Supplements: Zinc	2.2	2.4	5.3	-0.5	-0.9	-1.9	-1.9	-2.3	0.3	-0.9	-0.8	-1.9	-1.7	-0.9	-1.9	-0.6	-1.8	-1.8	-2.0	-1.8	-1.6
Arm predicted mass (right)	2.2	11.3	24.0	-1.8	-2.1	-2.2	-4.1	-4.5	-0.6	-4.9	-2.7	-3.3	-3.6	-3.3	-3.9	-0.1	-4.3	-4.1	-4.0	-3.8	-2.5
Whole body fat-free mass	2.2	12.6	25.7	-2.0	-2.1	-2.4	-4.2	-4.8	-0.9	-5.1	-2.7	-3.4	-3.7	-3.7	-4.2	0.2	-4.7	-4.3	-4.3	-4.1	-2.5
Arm fat-free mass (left)	2.2	11.0	22.8	-2.2	-1.8	-2.4	-3.8	-4.5	-0.9	-4.8	-2.5	-3.4	-3.4	-3.4	-3.9	-0.3	-4.3	-4.0	-3.9	-3.8	-2.7
LDL Cholesterol	2.1	3.4	8.6	-0.9	1.7	0.8	2.3	2.2	-1.9	1.9	2.5	1.4	2.9	0.5	1.6	-0.2	1.9	2.4	2.8	1.1	1.1
Average weekly fortified wine intake	2.1	2.5	4.3	-1.8	-1.2	-2.1	-1.5	-1.8	-1.2	-1.5	-0.4	-2.0	-0.8	-1.3	-2.0	-0.9	-2.0	-1.6	-1.3	-2.1	-1.6
Allergy	2.1	4.9	13.2	0.8	3.6	2.4	2.5	2.0	0.2	2.4	1.7	2.3	2.4	1.5	2.3	0.9	2.8	2.6	2.5	2.1	2.1
Pain all over the body in last month	2.1	2.3	4.9	1.0	0.2	1.3	1.8	2.2	0.2	1.6	1.6	1.7	1.8	1.3	1.4	1.3	1.6	2.0	1.7	1.2	1.8
Arm predicted mass (left)	2.1	10.9	21.4	-2.2	-1.6	-2.5	-3.8	-4.5	-0.9	-4.6	-2.5	-3.4	-3.4	-3.3	-3.9	-0.3	-4.3	-4.0	-3.8	-3.8	-2.6
Hayfever, allergic rhinitis or eczema	2.0	4.3	8.3	-0.2	-1.9	-1.4	-2.7	-2.3	-0.1	-2.2	-1.6	-2.0	-2.6	-1.8	-2.6	0.1	-2.8	-2.6	-2.9	-2.4	-1.7
Leg fat-free mass (right)	2.0	10.7	23.5	-1.7	-2.4	-1.9	-3.8	-4.7	-0.5	-4.8	-2.7	-2.9	-3.7	-3.2	-3.6	0.3	-4.2	-4.1	-4.1	-3.4	-2.3
Smoking status: Current	2.0	3.2	5.8	-0.7	1.2	-0.2	2.4	2.1	-0.7	2.2	2.2	1.3	2.3	2.1	2.1	-1.2	2.0	2.1	2.4	1.9	0.6
Leg predicted mass (right)	2.0	10.6	23.3	-1.7	-2.5	-1.9	-3.8	-4.6	-0.5	-4.8	-2.7	-2.9	-3.7	-3.2	-3.6	0.4	-4.2	-4.1	-4.1	-3.4	-2.2
Alzheimer’s Disease (in father)	1.9	2.0	6.0	0.4	0.1	-0.2	1.9	1.9	0.6	1.1	0.5	1.1	1.7	2.5	1.6	-0.4	1.8	1.9	1.9	1.5	1.1
Maternal smoking around birth	1.9	2.8	7.7	-1.4	0.2	0.4	2.3	2.2	-1.6	1.3	2.8	1.3	2.3	0.5	1.7	-1.2	2.0	1.8	2.3	1.4	0.4
Average weekly red wine intake	1.9	2.7	6.9	-0.8	-0.5	-0.6	-2.3	-2.2	-1.3	-2.0	-0.4	-1.4	-1.1	-1.9	-2.5	0.7	-2.0	-1.7	-2.0	-2.6	-0.9
Ever had hysterectomy (womb removed)	1.8	2.0	4.0	1.1	0.6	1.0	2.0	1.9	1.2	0.9	-0.3	1.6	1.0	1.6	1.9	0.7	1.7	1.6	1.4	2.0	1.5
Illness, injury, bereavement, stress in last 2 years	1.8	2.3	4.0	1.9	-0.0	1.7	1.5	2.0	1.4	0.9	0.0	1.9	0.8	1.8	1.9	1.1	1.7	1.5	1.1	2.0	1.7
Hypertension (Self-reported)	1.8	5.0	19.0	2.7	0.3	0.6	-2.1	-2.0	4.4	-1.0	-4.0	-0.5	-3.9	-0.4	-0.8	2.4	-1.8	-2.3	-2.9	-0.1	0.6
Basal metabolic rate	1.8	9.7	21.1	-1.9	-1.9	-2.1	-3.6	-4.3	-0.7	-4.6	-2.4	-3.0	-3.3	-3.2	-3.6	0.1	-4.1	-3.8	-3.7	-3.5	-2.2
Leg fat-free mass (left)	1.7	9.1	20.8	-1.8	-2.5	-1.9	-3.4	-4.1	-0.6	-4.6	-2.4	-2.7	-3.2	-3.0	-3.4	0.3	-3.9	-3.7	-3.6	-3.2	-2.0
High blood pressure	1.7	4.8	18.0	2.5	-0.3	0.4	-1.9	-1.6	4.2	-1.1	-4.1	-0.5	-3.9	-0.3	-0.7	2.1	-1.8	-2.3	-2.8	0.0	0.4
Leg predicted mass (left)	1.7	9.2	21.2	-1.7	-2.5	-1.9	-3.5	-4.2	-0.6	-4.6	-2.4	-2.7	-3.3	-3.1	-3.4	0.4	-3.9	-3.7	-3.7	-3.2	-2.0
Birth weight	1.7	3.6	8.6	-2.0	-2.9	-2.1	-1.7	-2.4	-1.8	-2.4	0.3	-2.0	-1.0	-1.3	-2.1	-1.2	-2.0	-1.8	-1.4	-2.2	-1.9
Frequency of depressed mood in last 2 weeks	1.6	2.3	5.9	1.1	1.3	0.2	1.7	1.2	1.5	2.3	0.3	1.4	0.9	2.4	1.9	0.5	1.6	1.5	1.5	2.0	1.6
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.5	-0.2	-0.8	-0.3	-1.5	-1.1	-0.1	-1.9	-1.5	-1.2	-1.7	-1.5	-1.5	0.0	-1.8	-1.6	-1.8	-1.4	-1.1
Serious illness, injury or assault to yourself	1.6	2.0	4.9	-0.2	-0.6	0.0	-1.9	-2.2	0.2	-1.4	-1.4	-0.9	-1.8	-2.0	-1.5	0.9	-1.6	-1.8	-1.9	-1.3	-0.6
Diabetes (self-reported)	1.6	2.5	6.1	2.5	-0.7	2.2	1.1	0.8	2.2	1.1	-1.1	2.0	-0.1	1.8	1.6	1.9	1.6	0.9	0.5	1.9	2.0
Mean time to correctly identify matches	1.6	3.1	7.5	1.5	0.8	2.1	1.7	1.5	-0.2	2.7	1.4	2.2	2.0	0.5	1.4	2.2	1.9	2.1	1.6	1.2	2.3
Commuting to job workplace: Walk	1.6	1.7	5.8	-0.6	-0.1	-0.5	1.0	0.8	-1.4	2.0	2.4	0.7	2.4	1.5	0.6	-0.0	1.1	1.8	1.7	0.2	0.8
Depression (Nagel 2018)	1.5	2.2	8.1	2.2	0.8	0.6	1.2	0.5	2.8	1.9	-1.1	1.2	0.0	2.2	1.4	1.3	1.3	1.0	0.7	1.6	1.9
Reaction Time	1.5	2.9	9.4	1.8	1.3	2.0	1.2	1.2	0.4	3.1	1.3	2.0	1.7	0.6	1.2	2.3	1.8	2.0	1.4	1.1	2.4
Respiratory disease	1.5	3.3	11.2	-0.8	-3.3	-1.4	-1.8	-1.4	-0.0	-2.5	-1.7	-2.0	-1.7	-1.6	-2.0	-0.8	-2.0	-1.9	-1.8	-1.9	-1.7
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	5.1	1.2	-1.9	0.9	-1.6	-1.2	1.2	-1.7	-1.9	-0.1	-2.2	-1.0	-0.8	1.5	-1.1	-1.6	-2.0	-0.5	-0.0
Ever had bowel cancer screening	1.5	1.7	5.6	2.4	-0.4	1.4	-0.8	-1.1	2.3	-0.2	-2.0	0.6	-1.9	0.4	-0.2	2.1	-0.2	-0.9	-1.4	0.2	1.0
Number of self-reported non-cancer illnesses	1.5	2.6	6.0	1.0	-0.5	0.9	-1.7	-1.4	1.0	-2.0	-2.5	-0.4	-2.4	-2.5	-1.3	1.9	-1.6	-1.9	-2.3	-1.0	-0.1
Blood Platelet Count	1.4	16.7	64.0	-7.3	2.7	-3.6	1.7	1.2	-8.0	2.5	7.5	-1.6	5.4	-0.8	-0.5	-5.5	0.7	2.4	4.0	-1.7	-2.8
Lung FEV1/FVC ratio	1.4	7.3	13.3	-1.1	-1.1	-2.2	-3.4	-3.6	-0.4	-3.6	-2.1	-2.7	-3.3	-2.3	-3.0	-0.7	-3.5	-3.5	-3.4	-2.8	-2.5
Lung FVC	1.4	7.0	16.5	0.9	-0.2	1.4	3.4	4.1	0.7	2.4	1.7	2.5	3.2	2.5	3.2	0.4	3.3	3.6	3.6	3.0	2.5
Average weekly spirits intake	1.4	1.7	4.1	0.1	-0.8	-0.2	1.9	1.9	0.3	0.8	0.7	1.3	1.2	1.8	2.0	-0.3	1.3	1.4	1.7	2.0	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	3.7	1.2	0.9	0.5	1.5	1.3	1.8	1.9	-0.1	1.3	0.8	1.6	1.6	1.1	1.3	1.5	1.3	1.7	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	5.0	-0.1	2.2	0.3	1.8	1.2	-0.5	2.0	1.7	1.2	1.4	1.3	1.5	-0.2	1.3	1.2	1.4	1.5	0.8
Mouth/teeth dental problems: Loose teeth	1.4	1.6	4.3	-1.1	-1.6	-1.5	-1.1	-0.4	-0.1	-0.9	-0.8	-1.9	-1.1	-1.0	-1.1	-2.1	-1.2	-1.2	-0.9	-1.0	-2.0
Medication: Aspirin	1.4	1.8	4.6	1.6	0.2	2.1	1.0	1.3	0.8	1.1	0.7	1.9	0.8	0.6	1.2	2.1	1.5	1.4	0.8	1.2	1.9
Mother’s age at death	1.4	1.7	6.5	-1.5	-0.2	-2.5	-1.1	-2.2	-0.4	-1.0	-0.5	-1.7	-0.7	-0.3	-1.3	-1.1	-1.6	-1.3	-0.9	-1.3	-1.2
Financial situation satisfaction	1.4	1.8	3.6	-0.9	1.8	-0.0	1.5	1.5	-1.1	1.6	1.9	0.7	1.9	0.8	1.2	-1.0	1.4	1.5	1.8	1.0	0.3
Alzheimer’s Disease (in mother)	1.3	1.6	2.7	1.3	0.5	1.5	1.5	0.9	1.0	1.1	0.2	1.6	0.8	1.6	1.4	1.0	1.5	1.3	1.0	1.5	1.5
HbA1C	1.3	1.4	3.2	0.8	-0.2	1.8	1.5	1.3	-0.3	0.9	0.8	1.6	1.3	0.5	1.3	1.0	1.4	1.5	1.2	1.2	1.4
Type 2 Diabetes (T2D) (2018)	1.3	2.4	5.9	2.4	-0.3	2.3	1.1	0.8	2.2	1.2	-0.6	2.0	0.0	1.7	1.4	2.1	1.7	1.0	0.4	1.7	2.0
Chronotype (morning person)	1.3	3.1	8.6	-2.7	-0.1	-2.9	-1.2	-1.6	-0.9	-2.3	-0.3	-2.3	-0.9	-1.5	-1.5	-2.1	-2.0	-1.6	-0.9	-1.6	-2.0
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	3.7	1.2	-1.7	0.6	-1.6	-0.3	0.1	-1.8	-1.4	-0.6	-1.6	-1.8	-1.5	1.1	-1.4	-1.4	-1.9	-1.3	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	4.2	-1.4	-1.3	-0.7	-1.5	-1.4	-0.7	-1.6	-1.0	-1.6	-1.4	-2.0	-1.3	-1.0	-1.6	-1.9	-1.5	-1.2	-1.7
Neuroticism (2016)	1.2	1.7	5.2	0.4	1.6	0.0	1.6	1.1	0.5	2.3	1.4	1.0	1.3	1.8	1.1	0.4	1.4	1.6	1.4	1.0	1.3
Number of incorrect matches in round	1.2	2.0	7.0	2.6	1.9	2.4	0.5	0.5	2.0	1.9	-0.7	1.5	-0.4	1.0	0.8	1.8	1.2	0.6	-0.0	1.0	1.4
Hip circumference	1.2	5.2	15.6	-1.8	-1.9	-1.9	-2.3	-2.7	-0.5	-4.0	-1.8	-2.1	-2.5	-2.4	-2.1	-0.4	-3.0	-2.8	-2.6	-2.0	-1.9
Prospective memory result	1.2	1.4	8.6	-1.2	-2.9	-1.0	-0.5	-0.1	-1.1	-1.2	-0.8	-1.0	-0.7	-1.4	-0.5	-1.5	-0.9	-1.1	-0.6	-0.5	-1.5
Peak expiratory flow (PEF)	1.2	2.7	12.7	1.0	-1.5	-0.8	-1.5	-1.9	2.4	-2.1	-3.6	-1.0	-2.4	-0.3	-0.8	0.4	-1.5	-1.7	-1.8	-0.4	-0.3
Chest pain or discomfort	1.2	1.7	7.7	0.8	-0.2	-0.8	-1.4	-1.7	1.0	-0.9	-2.8	-1.2	-1.7	-0.2	-1.3	0.3	-1.5	-1.5	-1.5	-1.1	-0.5
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.2	0.6	1.6	1.1	1.6	1.1	0.8	2.1	0.5	1.3	0.6	1.1	1.7	-0.1	1.5	1.0	1.1	1.8	0.8
Vascular/heart problems diagnosed by doctor	1.2	3.3	14.5	-2.3	0.4	-0.3	1.4	1.0	-3.8	0.8	3.4	0.2	3.2	0.1	0.2	-1.7	1.3	1.8	2.2	-0.4	-0.5
Cholesterol lowering medication	1.2	1.8	5.5	2.2	0.2	1.7	0.9	1.2	2.4	1.4	-1.0	1.4	-0.4	1.4	1.4	1.2	1.2	0.7	0.3	1.7	1.4
Ulcerative Colitis	1.1	1.6	3.3	0.2	-0.9	-0.5	-1.6	-0.9	0.5	-1.8	-1.8	-0.7	-1.4	-1.4	-1.3	1.6	-1.7	-1.2	-1.6	-1.2	0.1
Headache pain in last month	1.1	1.8	5.2	1.5	2.3	2.2	1.0	1.0	1.0	1.2	0.3	1.4	1.0	-0.1	0.9	2.0	1.3	1.4	0.7	0.9	1.8
Glaucoma (self-reported)	1.1	1.3	4.7	2.2	0.3	2.0	0.5	0.4	1.2	1.2	-0.3	1.5	-0.1	0.6	0.8	1.9	0.9	0.5	0.1	1.0	1.5
Medication: Aspirin	1.1	1.4	4.0	1.4	0.1	1.8	0.9	1.2	0.9	0.7	0.6	1.7	0.5	0.4	1.1	2.0	1.3	1.1	0.6	1.2	1.7
Diabetes diagnosed by doctor	1.1	1.8	3.1	1.7	-1.0	1.8	1.1	0.9	1.6	1.1	-0.5	1.8	0.3	1.7	1.5	1.5	1.5	1.0	0.7	1.7	1.8
Blood Red Count	1.0	9.5	18.6	-0.6	1.7	-2.6	-3.9	-3.9	1.1	-2.1	-3.1	-3.6	-4.3	-2.2	-3.2	-1.5	-4.0	-4.3	-3.8	-2.8	-3.0
Medication: Co-codamol	1.0	1.1	3.2	-0.8	-0.2	1.0	1.2	1.4	-1.5	-0.5	1.8	1.1	1.5	-0.3	0.9	0.2	0.9	1.1	1.2	0.8	0.5
Taking other prescription medications	1.0	1.6	4.2	1.0	-1.5	0.8	-1.2	-0.5	1.1	-1.7	-2.0	-0.4	-1.8	-1.3	-0.9	1.3	-1.2	-1.3	-1.7	-0.7	-0.0
Medication: Ramipril	1.0	1.3	5.3	1.5	0.5	1.9	0.3	0.9	1.0	1.0	-0.1	1.5	0.2	0.1	0.9	2.3	0.8	0.9	0.3	0.9	1.8
Number of live births	1.0	1.5	4.5	-1.1	-0.1	-1.8	-1.1	-0.6	-0.4	-1.0	-0.7	-1.5	-1.3	-0.6	-0.8	-2.1	-1.3	-1.5	-1.0	-0.7	-2.0
Medication: Omeprazole	1.0	1.2	2.8	0.0	-1.2	0.3	-1.4	-0.9	-0.0	-1.2	-0.6	-1.0	-1.0	-1.7	-1.6	0.6	-1.2	-1.0	-1.3	-1.6	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.6	0.6	-0.6	0.8	1.6	1.2	0.7	1.3	0.3	1.1	0.8	1.6	1.4	-0.0	1.4	1.1	1.1	1.5	0.8
Leg pain on walking	1.0	1.3	3.4	-0.5	1.1	1.8	1.2	1.2	-1.7	0.0	1.8	1.1	1.7	-0.4	0.6	0.4	1.3	1.3	1.2	0.4	0.5
Medication: Blood pressure	1.0	1.9	5.6	0.7	0.3	-0.8	-1.6	-1.3	2.1	-0.9	-2.3	-1.2	-2.4	-0.4	-1.0	0.3	-1.6	-1.6	-1.9	-0.7	-0.6
Pain experienced in last month	1.0	1.7	4.3	-0.7	-2.1	-1.6	-1.7	-1.7	-0.5	-1.2	-1.0	-1.4	-1.1	-0.3	-1.4	-0.9	-1.4	-1.4	-1.2	-1.4	-1.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.1	-0.0	1.1	0.7	-1.2	-1.3	-1.1	0.4	0.6	-0.6	-0.6	-1.8	-1.6	0.5	-0.8	-0.9	-1.2	-1.7	-0.8
Pulse rate	0.9	1.5	6.7	-1.6	-0.9	-1.4	0.4	0.8	-1.9	0.9	2.6	-0.4	1.1	0.9	0.0	-2.2	0.2	0.5	0.8	-0.2	-1.3
Depression (self-reported)	0.9	1.0	2.4	0.5	1.1	1.4	1.4	1.6	0.3	0.7	1.0	1.2	0.8	0.6	1.1	0.5	1.3	1.1	0.8	1.1	0.8
Hair/balding pattern: Pattern 4	0.9	2.2	5.4	0.1	-0.4	0.4	-1.8	-2.3	0.2	-1.0	-2.1	-1.2	-1.6	-1.7	-2.0	1.1	-1.5	-1.7	-2.0	-1.9	-0.6
Worry too long after embarrassment	0.9	1.6	6.0	1.1	-2.5	-0.4	-1.4	-1.1	1.1	-0.5	-1.1	-0.7	-1.4	-0.6	-1.4	1.5	-1.7	-1.0	-1.6	-1.3	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.1	0.9	-0.1	0.5	-1.2	-1.1	1.0	-0.3	-1.4	-0.9	-1.2	-1.3	-1.4	0.6	-0.7	-0.8	-1.4	-1.4	-0.5
Illnesses of father: None of the above (group 1)	0.9	1.1	7.0	-0.5	1.4	0.7	0.9	0.4	-1.4	1.4	2.7	0.8	1.3	0.0	0.4	-0.1	0.9	0.9	0.9	0.2	0.1
Eye problems/disorders: Glaucoma	0.9	1.1	4.0	2.0	0.1	1.3	0.5	0.5	1.4	1.3	-0.4	1.2	-0.1	1.0	1.0	1.3	0.9	0.5	0.4	1.1	1.4
High cholesterol (Self-reported)	0.9	1.5	3.2	1.3	0.8	1.2	1.1	1.4	1.8	0.8	-0.4	1.4	0.2	1.5	1.5	1.2	1.1	1.0	0.7	1.7	1.6
Ovarian Cancer	0.8	1.0	3.7	1.2	-0.7	-0.8	0.8	1.2	1.8	0.9	-0.5	0.4	0.2	1.9	1.1	-0.2	0.8	0.9	0.8	1.2	0.8
Rheumatoid Arthritis	0.8	1.1	4.9	1.5	-0.7	0.3	-0.7	-1.1	1.7	-0.2	-2.2	-0.2	-1.8	0.0	-0.1	0.4	-0.6	-1.2	-1.3	0.2	-0.1
Cardiovascular Disease	0.8	2.7	14.7	1.7	1.0	0.1	-1.3	-1.2	3.8	-0.5	-3.2	-0.5	-2.8	0.0	-0.2	1.0	-1.0	-1.5	-1.9	0.4	0.2
Number of treatments/medications taken	0.8	1.4	3.7	1.2	-1.6	1.1	-0.9	-0.4	1.3	-1.7	-1.9	0.1	-1.6	-1.0	-0.5	1.7	-0.8	-1.0	-1.5	-0.3	0.3
Hearing difficulty/problems: Yes	0.8	1.2	4.6	-1.6	-1.5	-1.3	-0.7	-0.8	-0.5	-2.1	-0.7	-1.0	-0.9	-0.9	-0.8	-0.6	-1.3	-1.1	-0.9	-0.8	-0.9
Pack years adult smoking proportion	0.8	1.2	5.6	1.4	0.9	0.5	-0.8	-0.6	2.4	-0.4	-2.2	-0.1	-1.5	0.1	-0.3	1.5	-0.7	-0.6	-1.2	-0.0	0.6
Chronic bronchitis/emphysema (father)	0.8	0.9	2.0	-1.3	-0.4	-0.6	1.3	1.4	-1.0	0.2	1.2	0.5	1.4	0.9	0.9	-0.6	0.6	1.0	1.3	0.8	0.3
High blood pressure (mother)	0.8	1.2	4.0	-0.5	-0.7	-1.1	-1.0	-0.9	0.3	-2.0	-1.2	-1.1	-1.2	-1.6	-1.1	-0.0	-1.3	-1.1	-1.1	-1.0	-0.7
Medication: Simvastatin	0.8	1.2	4.8	1.6	1.0	1.1	0.6	0.9	2.2	0.9	-1.2	1.0	-0.6	1.2	1.1	1.1	0.6	0.2	0.0	1.4	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	8.6	1.2	2.9	1.5	0.4	0.1	0.6	1.8	0.2	0.9	0.4	0.2	0.3	1.7	0.7	0.7	0.4	0.3	1.4
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.3	0.4	1.3	0.9	1.1	1.5	0.0	1.5	0.9	1.0	1.1	0.3	0.9	0.8	0.9	1.1	1.1	0.8	1.2
Medication: Paracetamol	0.8	1.2	3.4	0.6	0.4	1.8	1.3	1.4	-0.3	1.2	0.6	1.5	1.2	0.1	1.1	1.0	1.3	1.3	1.2	1.0	1.1
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	5.7	-2.0	0.2	-0.7	-0.2	-0.2	-2.4	-0.3	1.4	-1.1	0.9	-1.0	-0.9	-2.1	-0.1	-0.0	0.4	-1.2	-1.7
Health satisfaction	0.8	1.1	3.9	1.7	-0.1	1.9	-0.4	0.0	1.5	-1.1	-2.0	0.7	-1.4	-0.2	0.3	1.2	0.1	-0.6	-1.0	0.6	0.3
Eye problems/disorders: None of the above	0.8	0.9	3.0	-1.6	-0.2	-1.7	-0.3	0.0	-1.2	-0.2	1.1	-1.2	0.5	-0.2	-0.8	-1.7	-0.4	0.0	0.1	-1.0	-1.4
Neck or shoulder pain in last month	0.8	1.1	2.5	1.1	0.7	1.4	1.0	1.2	1.1	1.1	-0.2	1.2	0.3	-0.0	1.5	0.3	1.4	0.9	1.0	1.6	0.8
Medication: Blood pressure	0.8	1.4	4.7	2.0	-1.0	0.8	0.1	0.2	2.2	0.5	-1.2	1.1	-1.0	0.9	0.8	2.2	0.0	-0.1	-0.4	1.1	1.6
Migraine (self-reported)	0.8	1.0	2.5	-1.3	1.4	-1.6	-0.8	-1.0	-0.4	-1.3	-0.4	-1.4	-0.5	-0.7	-1.0	-0.8	-1.3	-0.9	-0.7	-1.0	-0.9
Supplements: Vitamin C	0.8	0.9	2.6	0.6	0.4	0.4	1.1	0.8	0.2	0.9	0.9	1.2	1.0	1.6	1.0	0.9	1.0	1.2	1.0	1.0	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	3.9	-0.7	-0.6	-1.4	1.0	1.2	0.3	0.1	0.1	-0.1	0.6	1.6	1.1	-2.0	0.7	0.7	1.2	1.1	-0.4
Osteoarthritis (self-reported)	0.8	1.1	2.7	-1.6	-0.7	-1.4	-0.4	-0.1	-1.4	-1.0	1.2	-1.1	0.4	-1.2	-1.0	-1.4	-0.4	-0.1	-0.0	-1.2	-1.3
Guilty feelings	0.8	1.2	4.2	-0.9	-2.1	-1.5	-0.9	-0.8	-0.9	-0.6	0.4	-1.1	-0.4	-1.0	-1.4	0.3	-1.7	-0.9	-0.9	-1.5	-0.5
Myopia	0.8	1.1	2.6	0.1	-1.2	-0.7	-1.4	-1.3	0.4	-0.9	-0.6	-0.9	-1.6	-1.0	-1.1	0.4	-1.4	-1.5	-1.6	-0.9	-0.6
Pack years of smoking	0.8	1.2	6.5	1.6	0.5	0.8	-0.5	-0.3	2.5	-0.2	-2.2	0.1	-1.4	0.3	0.0	1.6	-0.5	-0.4	-1.0	0.3	0.9
Depressed Affect (Nagel 2018)	0.7	1.5	4.8	1.0	2.0	0.0	1.3	0.6	1.5	2.2	0.2	0.8	0.6	1.6	1.1	0.5	1.2	1.1	1.2	1.1	1.4
Bipolar Disorder (2011)	0.7	0.7	2.0	0.2	-0.6	-0.6	-1.2	-1.0	-0.2	0.3	-0.2	-0.9	-0.6	-1.0	-1.4	0.4	-1.1	-0.6	-1.0	-1.4	-0.4
Coronary Artery Disease (CAD)	0.7	0.9	2.8	1.1	0.9	-0.1	0.8	0.8	1.7	-0.0	-1.3	0.8	0.0	1.2	1.2	0.6	0.8	0.7	0.4	1.5	1.0
BMI	0.7	4.1	11.7	-1.9	-3.3	-2.2	-1.7	-2.3	-0.3	-3.4	-1.1	-1.6	-2.0	-1.5	-1.8	0.1	-2.6	-2.2	-2.0	-1.7	-1.1
Systolic blood pressure, automated reading	0.7	2.0	6.8	0.3	-2.6	-1.0	-1.2	-0.9	1.6	-1.9	-2.3	-1.2	-2.1	-0.4	-0.7	-0.5	-1.3	-1.6	-1.6	-0.4	-1.0
Trunk fat percentage	0.7	2.7	5.9	0.8	-0.5	1.5	2.2	1.9	0.7	0.7	0.7	2.3	1.3	1.6	2.4	0.9	2.1	1.8	1.8	2.4	1.8
Relative age voice broke	0.7	1.0	4.7	-0.6	2.2	-0.1	-0.9	-1.5	-0.7	0.0	-0.3	-1.1	-0.6	-1.3	-1.0	-1.0	-0.5	-1.0	-0.7	-1.0	-1.3
Medication: Levothyroxine sodium	0.7	1.2	3.5	-1.6	-0.4	-1.9	-0.7	-1.1	-1.4	-0.6	0.6	-1.2	-0.3	-1.3	-0.8	-1.7	-0.9	-0.9	-0.4	-0.9	-1.5
Asthma	0.7	1.5	8.8	-0.9	-3.0	-1.3	-0.9	-0.6	-0.2	-1.8	-1.0	-1.0	-1.1	-0.5	-0.8	-0.6	-1.4	-1.2	-1.0	-0.7	-1.0
Lung cancer (father)	0.7	0.8	2.2	0.4	0.1	0.9	1.3	1.5	-0.7	1.0	1.2	1.1	1.0	0.0	0.9	0.1	1.0	1.0	0.9	0.8	0.4
Tense / ‘highly strung’	0.7	1.2	4.8	2.2	2.1	0.7	-0.2	0.2	2.1	1.2	-1.1	0.4	-0.8	0.7	0.2	1.5	-0.1	0.1	-0.3	0.4	1.1
Heart disease (mother)	0.7	0.8	2.8	1.0	1.7	1.4	0.7	1.0	0.6	-0.1	-0.5	1.3	-0.2	0.6	1.0	1.0	0.7	0.3	0.1	1.2	0.8
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.2	0.7	-0.9	1.0	-1.1	-0.7	0.4	-1.0	-0.7	-0.3	-1.0	-1.2	-1.1	1.5	-0.8	-0.8	-1.2	-1.1	0.2
Breast Cancer	0.6	1.5	8.5	-1.6	1.3	0.1	0.6	0.5	-1.9	1.1	2.9	0.1	1.9	0.7	-0.1	-1.0	1.0	1.2	1.3	-0.5	-0.3
Age at First Birth	0.6	0.9	2.7	-1.3	-0.7	-0.4	-0.9	-1.2	-1.4	-1.7	0.4	-0.7	-0.0	-1.3	-1.1	0.1	-1.1	-0.7	-0.7	-1.3	-0.6
Body Mass Index (BMI) (2010)	0.6	0.9	2.2	-0.7	0.1	-0.6	1.1	1.1	0.1	0.2	0.5	0.8	1.3	1.5	1.3	0.1	0.8	1.2	1.3	1.2	1.0
Hypothyroidism (self reported)	0.6	1.4	4.7	-0.7	0.5	-0.6	-1.3	-1.4	-0.5	-1.7	-1.1	-1.1	-1.0	-2.2	-1.2	0.2	-1.4	-1.3	-1.3	-1.2	-0.8
Diabetes (father)	0.6	0.8	5.3	0.6	0.8	0.9	-0.4	-0.4	1.2	-1.1	-2.3	-0.0	-0.9	-0.8	-0.1	1.0	-0.3	-0.6	-0.7	0.0	0.5
Hand grip strength (right)	0.6	1.5	7.8	-1.3	2.1	-0.1	0.4	0.1	-2.0	1.0	2.8	0.6	2.0	0.5	0.2	0.3	0.6	1.2	1.2	-0.2	0.7
Stomach or abdominal pain in last month	0.6	0.7	2.9	-0.1	0.5	0.1	-0.8	-0.9	0.3	-0.4	-1.7	-0.9	-1.0	-1.2	-0.7	-0.5	-0.8	-1.1	-1.0	-0.5	-0.9
Medication: Atenolol	0.6	0.7	1.8	-0.6	0.2	-0.8	-0.8	-0.3	0.3	-1.3	-0.8	-1.1	-1.0	-1.2	-0.7	-0.6	-1.1	-0.9	-0.9	-0.6	-1.0
Time employed in main current job	0.6	0.7	1.9	-0.1	1.1	1.0	0.7	0.0	-0.3	0.9	0.5	1.2	0.9	0.1	0.8	1.4	0.6	0.7	0.7	0.8	1.3
Noisy workplace	0.6	0.7	2.8	-1.4	-0.8	-0.1	-0.5	-0.6	-1.4	-1.7	0.2	-0.4	-0.2	-1.4	-0.7	-0.1	-0.7	-0.8	-0.2	-0.8	-0.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.3	1.8	-0.1	1.4	0.5	0.9	1.5	0.8	-0.7	0.9	-0.4	0.1	0.7	1.3	0.5	0.3	-0.1	0.8	1.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	6.1	-1.3	0.7	-0.7	-0.8	-1.1	-1.5	-1.0	0.3	-0.9	-0.1	-2.5	-1.1	0.2	-1.1	-0.8	-0.6	-1.2	-0.5
High blood pressure (siblings)	0.6	0.9	1.8	0.3	0.0	-0.5	-1.1	-0.7	1.1	-1.1	-1.3	-0.9	-1.2	-1.1	-0.9	0.7	-1.3	-0.9	-1.3	-0.8	-0.2
Body fat percentage	0.6	2.4	5.1	0.6	-0.6	1.3	2.1	2.0	0.5	0.6	0.8	2.0	1.4	1.4	2.2	0.6	2.0	1.8	1.9	2.3	1.6
Number of children fathered	0.6	0.7	3.1	1.0	1.7	1.8	0.7	0.4	0.5	0.8	-0.2	0.9	0.1	-0.2	0.8	0.7	1.0	0.3	0.2	0.9	0.6
Medication: Seretide 50 evohaler	0.6	0.7	3.0	-1.0	-1.1	-0.8	-0.3	-0.0	-0.2	-1.7	-0.7	-1.0	-0.5	-1.0	-0.5	-1.3	-0.5	-0.6	-0.4	-0.5	-1.2
Suffer from ‘nerves’	0.6	1.0	3.6	1.8	0.4	1.3	-0.2	0.2	1.6	-0.2	-1.6	0.7	-1.0	-0.4	0.1	1.9	-0.1	-0.2	-0.8	0.4	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	3.8	-0.6	-0.6	0.4	-0.7	-0.5	-1.1	-2.0	-0.2	-0.4	-0.8	-1.1	-0.6	-0.7	-0.7	-1.0	-0.8	-0.5	-1.1
Long-standing illness, disability or infirmity	0.6	0.9	4.0	0.4	-1.7	-0.2	-0.5	-0.8	1.1	-1.4	-2.0	-0.2	-1.5	-0.1	-0.0	0.1	-0.7	-1.1	-1.0	0.3	-0.2
Friendships satisfaction	0.6	0.7	2.3	0.5	-0.5	-1.0	-0.9	-1.1	1.5	-0.2	-1.4	-1.1	-1.0	0.3	-0.8	0.0	-0.8	-0.7	-0.8	-0.7	-0.2
Breast cancer (self-reported)	0.6	0.8	4.1	1.5	-1.2	0.7	-0.1	-0.1	2.0	0.0	-1.0	0.5	-0.9	0.7	0.4	1.0	0.3	-0.1	-0.3	0.7	0.9
Bipolar Disorder (2018)	0.5	0.7	3.6	1.3	1.4	-0.1	0.4	0.4	1.0	1.9	0.2	0.5	0.2	1.4	0.6	0.4	0.5	0.6	0.4	0.6	0.8
Neuroticism (Nagel 2018)	0.5	1.1	5.7	1.8	0.7	-0.1	0.4	0.2	2.4	1.5	-0.6	0.5	-0.3	1.6	0.6	1.2	0.3	0.6	0.2	0.7	1.4
Worry (Nagel 2018)	0.5	1.1	5.5	2.1	1.3	0.2	-0.1	0.1	2.4	1.0	-0.9	0.5	-0.8	1.2	0.3	1.5	-0.1	0.0	-0.4	0.5	1.1
Mean Putamen Volume	0.5	0.6	4.0	-1.2	0.6	-1.4	0.4	-0.4	0.2	0.3	0.1	-0.6	0.1	0.6	0.4	-2.0	0.3	-0.0	0.5	0.4	-0.9
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.6	1.1	0.9	0.4	0.6	0.5	1.2	0.8	-0.3	0.8	-0.2	1.2	0.7	0.5	0.8	0.5	0.3	0.9	0.7
Height	0.5	10.1	25.0	-0.7	-0.8	-2.5	-4.1	-5.0	0.3	-3.1	-2.8	-3.5	-3.9	-2.0	-3.8	-0.3	-4.3	-4.1	-4.0	-3.6	-2.4
Tanning	0.5	6.2	31.7	1.9	5.6	1.0	2.0	1.8	2.8	4.8	0.1	1.6	1.2	1.7	2.2	1.6	2.0	2.0	1.8	2.3	2.7
Hand grip strength (left)	0.5	1.3	8.0	-1.6	1.2	-0.4	0.2	-0.1	-2.3	0.6	2.8	0.2	1.8	0.2	-0.3	-0.2	0.3	1.0	1.0	-0.7	0.1
Relative age of first facial hair	0.5	1.0	5.8	1.2	2.4	0.9	-0.6	-1.1	1.3	0.3	-1.5	0.0	-1.3	0.3	-0.1	0.3	-0.1	-0.9	-1.0	0.2	-0.2
Ever used hormone-replacement therapy (HRT)	0.5	0.7	3.8	1.7	0.2	1.9	0.1	0.1	0.9	0.3	-0.2	1.0	-0.2	0.6	0.4	1.2	0.7	0.2	-0.4	0.5	0.7
Medication: Metformin	0.5	0.7	3.1	1.1	-0.7	1.8	0.3	0.4	0.5	0.4	0.2	1.2	0.2	0.5	0.5	1.6	0.8	0.5	0.1	0.5	1.1
Severe depression (siblings)	0.5	0.5	1.2	-0.1	-1.1	-0.4	-0.7	-0.8	-0.0	-1.0	-0.7	-0.7	-0.7	-0.5	-0.9	-0.4	-0.5	-0.8	-0.8	-0.9	-0.8
Hearing difficulty/problems with background noise	0.5	0.8	2.6	-0.6	0.5	-0.7	1.3	1.1	0.4	0.6	0.1	0.4	0.6	1.6	1.2	-0.9	0.7	0.7	1.0	1.3	0.3
Financial difficulties in last 2 years	0.5	0.7	1.3	0.6	0.8	1.1	1.1	0.6	0.5	1.1	-0.1	1.0	0.4	0.8	1.1	0.5	0.9	0.7	0.7	1.1	0.9
Illnesses of siblings	0.5	0.7	3.0	-0.8	0.3	0.7	0.8	0.4	-1.7	0.3	1.3	0.6	1.3	0.2	0.5	-0.7	0.9	0.7	1.0	0.3	-0.1
Weight	0.5	2.7	9.3	-1.2	-1.7	-1.1	-1.6	-2.2	-0.2	-3.0	-1.4	-1.2	-1.8	-1.6	-1.5	0.2	-2.1	-1.9	-1.8	-1.4	-1.0
Medication: Cholesterol lowering	0.5	0.7	2.3	1.1	0.9	0.1	0.5	0.6	1.5	0.4	-0.5	0.9	-0.2	1.5	1.1	0.7	0.4	0.4	0.3	1.3	1.0
Illnesses of mother	0.5	0.6	2.7	-0.3	-0.5	0.6	0.5	0.4	-1.2	1.1	1.6	0.6	1.3	0.4	0.4	-0.1	0.8	0.8	1.0	0.2	0.3
Standing height	0.5	4.5	11.2	-0.0	-0.5	-0.9	-2.9	-3.4	0.2	-2.2	-2.0	-1.9	-2.6	-1.6	-2.7	0.9	-2.8	-2.7	-2.9	-2.5	-1.0
Breastfed as a baby	0.5	0.6	1.6	-1.3	0.7	-1.1	0.6	0.3	-0.6	0.3	1.2	-0.1	1.1	1.0	0.5	-0.7	0.1	0.7	1.0	0.3	0.2
Pulse wave reflection index	0.5	0.6	3.7	1.4	-0.0	0.6	0.2	-0.2	1.9	0.7	-1.2	0.3	-0.9	0.7	0.6	0.1	0.4	-0.2	-0.2	0.8	0.3
Medication: Amlodipine	0.5	0.7	3.1	1.4	-0.4	0.4	0.3	-0.1	1.8	0.9	-0.7	0.7	-0.5	0.8	0.7	1.4	0.3	0.2	-0.1	0.9	1.2
Leg fat percentage (right)	0.5	1.8	4.4	-0.1	-0.1	0.6	1.9	2.1	0.0	0.7	1.1	1.4	1.6	0.9	1.7	-0.0	1.7	1.8	1.9	1.6	1.1
Medication for pain relief, constipation, heartburn	0.5	0.8	3.4	-1.5	0.5	-1.6	0.4	0.1	-1.3	0.1	1.1	-0.5	0.7	0.9	0.2	-1.8	-0.0	0.0	0.7	0.1	-0.8
Family relationship satisfaction	0.5	0.7	4.2	0.8	2.1	0.4	0.2	-0.4	1.0	1.7	-0.1	0.1	0.4	1.0	0.0	0.6	0.6	0.5	0.4	-0.0	0.8
Illnesses of siblings: Diabetes	0.5	0.6	1.7	-0.7	-0.7	-1.3	-0.6	-0.1	-0.2	-0.3	-0.2	-1.3	-0.4	-0.8	-1.0	-0.6	-1.0	-0.6	-0.4	-1.0	-0.7
Medication for cholesterol	0.5	0.8	5.4	-1.2	-0.8	-0.7	-0.1	-0.4	-2.3	-0.0	1.3	-0.4	1.0	-0.9	-0.8	-0.2	-0.4	0.1	0.4	-1.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.5	0.1	-1.2	0.1	1.3	1.6	-0.2	0.6	0.6	0.9	1.3	1.3	1.1	-0.2	1.1	1.3	1.3	1.0	0.7
Alcohol drinker status: Never	0.5	0.5	2.6	1.1	0.4	1.2	-0.6	-0.3	0.6	-0.1	-0.6	0.2	-0.8	-0.6	-0.4	1.6	-0.6	-0.6	-1.0	-0.2	0.6
Diastolic blood pressure, automated reading	0.5	1.5	8.2	-0.2	-2.9	-2.1	-0.3	-0.3	1.6	-1.0	-1.5	-1.1	-1.0	1.4	0.1	-1.6	-0.7	-0.6	-0.3	0.3	-0.8
Basal cell carcinoma (self-reported)	0.5	0.6	1.8	-0.3	0.7	0.4	0.8	0.6	-1.1	0.3	1.3	0.5	1.4	-0.4	0.1	0.6	0.6	1.0	1.0	-0.2	0.8
Irritable Bowel Disease (IBD)	0.4	1.0	4.0	-1.1	1.1	-0.7	-1.0	-0.9	-0.7	-1.3	-0.3	-1.0	-0.4	-2.0	-1.3	0.3	-1.3	-0.7	-0.9	-1.4	-0.5
Prostate Cancer	0.4	0.6	1.4	-0.6	-0.6	-0.4	-0.8	-0.5	-0.4	-0.8	-0.6	-1.0	-0.5	-1.0	-1.1	0.0	-1.1	-0.7	-0.7	-1.2	-0.5
Crohns Disease (2012)	0.4	0.6	3.3	0.8	1.2	0.5	-0.4	-0.8	0.7	-0.1	-1.1	0.2	-0.5	-0.7	-0.4	1.8	-0.6	-0.4	-0.7	-0.3	0.8
Sensitivity / hurt feelings	0.4	0.6	3.0	0.9	-0.9	-0.4	-0.6	-0.1	1.7	-0.2	-1.6	-0.5	-1.4	0.5	-0.3	-0.1	-0.6	-0.6	-0.7	-0.0	-0.2
Age when periods started (menarche)	0.4	0.9	3.6	-1.5	-1.9	-1.3	0.3	0.4	-1.3	-1.0	0.6	-0.4	0.7	0.0	0.1	-1.7	0.2	0.2	0.8	-0.0	-0.9
Had menopause	0.4	0.5	1.8	0.5	-1.3	-0.1	-0.7	-0.3	0.8	-0.9	-1.1	-0.3	-1.3	-0.2	-0.3	-0.0	-0.6	-0.9	-1.0	-0.1	-0.4
Heart attack	0.4	0.6	1.6	-0.0	0.1	-1.3	-0.9	-0.6	0.8	0.0	-0.6	-1.2	-0.9	-0.1	-0.7	-0.9	-0.7	-0.8	-0.7	-0.6	-0.9
Arm fat percentage (right)	0.4	1.7	3.7	0.2	-0.8	1.0	1.9	1.5	0.3	0.2	0.7	1.8	1.1	0.9	1.9	0.8	1.5	1.4	1.4	1.9	1.4
Happiness	0.4	0.4	2.8	0.5	1.3	-0.6	0.3	0.2	1.7	0.7	-0.9	-0.3	-0.2	0.6	0.4	-0.3	0.4	0.3	0.3	0.5	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.1	-0.0	0.4	-0.7	-0.6	-0.7	0.2	-0.3	-1.0	-1.0	-0.4	-0.5	-0.9	-0.1	-0.7	-0.6	-0.6	-1.0	-0.4
Blood clot in the leg (DVT)	0.4	0.5	2.3	-1.2	-0.0	-0.8	-0.2	-0.5	-1.4	0.1	0.9	-0.5	0.1	-0.5	-0.2	-1.5	-0.1	-0.3	0.1	-0.2	-1.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.2	-0.4	-0.7	0.7	-0.5	0.1	-1.5	-0.8	0.8	-0.3	-0.0	-1.2	-0.7	-0.6	-0.2	-0.4	-0.3	-0.8	-1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.6	-0.0	1.2	-0.2	0.8	0.6	0.0	0.7	1.0	0.4	1.1	0.9	0.3	0.3	0.7	1.1	1.0	0.1	0.8
Asthma (self-reported)	0.4	0.9	6.3	-0.6	-2.5	-1.1	-0.6	-0.3	0.1	-1.4	-1.0	-0.7	-0.9	-0.1	-0.5	-0.4	-1.1	-0.9	-0.7	-0.4	-0.6
Medication: Lisinopril	0.4	0.5	2.7	0.2	-1.6	-0.7	-0.5	-0.8	0.7	0.1	-0.6	-0.7	-0.9	-0.4	-0.6	0.0	-0.7	-0.9	-0.8	-0.5	-0.3
Leg fat percentage (left)	0.4	1.5	3.2	0.1	0.1	0.8	1.8	1.7	0.5	0.6	0.7	1.4	1.2	0.9	1.8	0.2	1.6	1.6	1.7	1.8	1.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	2.8	-1.3	0.1	-0.7	0.1	-0.4	-1.4	0.1	0.9	-0.3	0.3	-0.4	0.0	-1.7	0.1	-0.1	0.3	-0.0	-1.2
Heart disease (siblings)	0.4	0.5	2.1	1.4	0.0	0.5	-0.5	-0.0	1.4	0.3	-1.1	0.5	-0.8	0.4	0.1	1.4	-0.2	-0.1	-0.5	0.2	0.8
Systolic Blood Pressure	0.3	1.7	5.8	1.4	-2.4	-0.3	-0.9	-0.5	2.2	-0.9	-2.3	-0.5	-2.1	-0.1	-0.2	-0.0	-0.8	-1.3	-1.5	0.2	-0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	2.0	0.1	-1.4	-0.1	0.7	1.0	-0.2	-0.1	0.1	0.6	0.4	0.5	0.6	0.4	-0.0	0.5	0.6	0.6	0.7
Angina	0.3	0.4	1.4	0.9	-0.8	0.1	0.4	0.4	1.2	-0.0	-0.8	0.6	-0.3	1.1	0.8	0.4	0.5	0.2	0.1	1.0	0.7
Diabetes (mother)	0.3	0.4	3.5	-0.3	-1.9	-0.2	0.2	0.8	-0.1	-0.8	0.3	-0.0	0.0	-0.1	0.3	-0.9	0.2	0.1	0.2	0.4	-0.6
Hair/balding pattern: Pattern 3	0.3	0.5	2.5	-0.8	-1.6	-1.1	-0.6	-0.4	-0.7	-0.9	0.3	-0.6	-0.2	-0.6	-0.5	-0.5	-0.7	-0.5	-0.4	-0.5	-0.7
Birth weight of first child	0.3	0.5	1.2	-0.1	-0.7	-0.2	-0.8	-0.5	-0.3	-0.9	-0.9	-0.5	-0.9	-0.4	-0.7	-0.2	-0.9	-1.0	-1.1	-0.6	-0.8
Gout (self-reported)	0.3	0.4	2.4	0.2	-1.5	0.6	-0.4	-0.4	-0.1	-0.9	0.1	0.7	-0.5	0.2	0.0	1.2	-0.3	-0.3	-0.6	0.1	0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	2.4	-0.4	-1.2	0.4	0.7	1.6	-0.7	-0.3	0.4	0.4	0.9	0.0	0.5	-0.2	0.6	0.7	0.8	0.4	0.2
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.6	1.0	0.7	-0.0	0.2	0.5	1.3	0.7	-1.2	0.0	-0.2	0.2	0.3	0.4	0.2	0.2	0.0	0.4	0.5
Wheeze or whistling in the chest in last year	0.3	0.5	2.9	-0.2	-0.3	0.1	-0.4	-0.6	0.4	-1.2	-1.7	-0.4	-0.9	-1.1	-0.3	0.2	-0.8	-0.8	-0.7	-0.1	-0.2
Emphysema/chronic bronchitis	0.3	0.4	1.3	0.2	-0.6	-0.0	1.0	1.2	0.2	0.4	0.4	0.5	0.8	0.2	0.5	0.6	0.5	1.0	0.7	0.4	0.8
Angina (self-reported)	0.3	0.4	1.3	0.9	-0.5	-0.0	0.5	0.5	1.0	0.1	-0.6	0.7	-0.1	1.1	0.9	0.4	0.5	0.3	0.2	1.0	0.7
Pulse rate, automated reading	0.3	0.9	6.4	0.1	-2.5	-0.1	0.3	1.0	-0.5	1.1	1.5	0.4	0.6	1.2	0.6	-1.1	0.8	0.6	0.7	0.6	-0.4
Alcohol intake frequency.	0.3	0.8	4.0	1.5	1.6	2.0	0.5	0.7	0.8	0.5	-0.5	0.8	-0.1	-0.4	0.4	1.3	0.5	0.4	-0.0	0.5	0.8
Arm fat percentage (left)	0.3	1.1	2.5	0.2	-1.0	0.9	1.5	1.2	0.4	-0.1	0.5	1.5	0.8	0.7	1.5	0.8	1.2	1.1	1.1	1.6	1.2
Mood swings	0.3	0.6	3.7	-1.0	1.9	-1.1	0.7	0.3	-0.1	0.6	0.6	-0.5	0.7	0.1	0.2	-1.3	0.3	0.5	1.0	0.1	-0.3
Medication: Paracetamol	0.3	0.4	1.3	0.0	0.1	1.1	0.8	0.9	-0.6	0.6	0.4	0.8	0.8	-0.2	0.6	0.5	0.7	0.8	0.7	0.5	0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	-0.1	0.1	-1.1	-0.7	-0.4	0.5	0.2	-0.2	-1.0	-0.7	-0.2	-0.7	-0.8	-0.6	-0.6	-0.5	-0.6	-0.8
Alcohol drinker status: Previous	0.3	0.3	1.8	0.4	-0.6	1.4	0.2	0.3	-0.3	-0.7	-0.4	0.2	-0.1	-1.2	-0.2	0.6	0.0	0.0	-0.4	-0.2	-0.1
Crohns Disease (2017)	0.2	0.5	5.3	-0.6	2.3	0.3	0.5	-0.0	-0.6	0.4	0.6	0.2	0.8	-0.7	-0.0	0.5	0.1	0.4	0.4	-0.2	0.4
Lupus	0.2	0.3	1.2	-0.7	-0.4	-0.9	-0.2	-0.5	-0.6	-1.1	0.4	-0.3	0.0	-0.7	-0.3	0.1	-0.6	-0.3	-0.1	-0.3	-0.1
Heel T-Score	0.2	1.8	6.3	0.9	1.9	0.2	1.4	1.1	1.2	1.9	0.5	0.8	0.8	2.5	1.5	-1.0	1.6	1.2	1.3	1.6	0.4
Neuroticism	0.2	0.4	2.2	0.4	-0.3	-1.5	0.0	-0.3	1.2	1.1	0.3	-0.4	-0.1	1.2	-0.2	0.1	-0.1	0.2	0.1	-0.2	0.4
Medication for hormone replacement therapy	0.2	0.3	1.5	-0.4	1.2	0.7	0.3	0.2	-0.4	-0.1	0.4	0.4	0.3	-0.1	0.6	-0.5	0.6	0.1	0.2	0.7	-0.2
Body mass index (BMI)	0.2	0.9	5.1	-1.3	-1.6	-0.8	-0.4	-0.9	-0.4	-2.3	-0.6	-0.5	-0.8	-1.0	-0.5	-0.1	-1.0	-1.0	-0.7	-0.4	-0.6
Forced vital capacity (FVC)	0.2	0.7	2.4	0.6	-1.1	-0.5	0.8	0.9	1.5	0.3	-0.8	0.2	0.3	1.5	0.9	-0.4	0.5	0.7	0.8	1.0	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.2	0.6	-0.0	0.7	0.5	1.1	0.3	0.9	0.6	0.6	0.5	0.9	0.6	0.1	0.8	0.7	0.6	0.6	0.5
Worrier / anxious feelings	0.2	0.4	0.9	-0.4	0.8	-0.5	-0.7	-0.9	-0.5	0.4	0.8	-0.3	-0.4	-0.5	-0.8	0.8	-0.9	-0.6	-0.7	-0.8	0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.7	0.6	-1.4	-0.9	-0.3	-0.1	1.6	-0.8	-1.6	-0.6	-0.9	0.7	-0.0	-0.3	-0.5	-0.4	-0.4	0.2	-0.1
Pulse wave Arterial Stiffness index	0.2	0.3	0.9	0.7	0.3	0.4	-0.1	-0.4	0.9	0.2	-1.0	-0.0	-0.9	0.5	0.1	-0.3	-0.1	-0.7	-0.6	0.4	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.8	-0.8	0.5	-0.7	-0.4	-0.8	-0.5	-0.2	0.3	-0.8	-0.2	-0.7	-0.8	-0.2	-0.7	-0.5	-0.4	-0.9	-0.4
Loud music exposure frequency	0.2	0.2	0.8	0.0	-0.1	0.0	0.4	0.7	-0.4	0.9	0.4	0.2	0.4	0.3	0.4	-0.6	0.4	0.4	0.5	0.4	-0.1
Pulse wave peak to peak time	0.2	0.2	0.7	-0.5	-0.0	-0.2	0.0	0.1	-0.7	-0.2	0.8	0.0	0.8	-0.5	-0.2	0.5	0.1	0.6	0.5	-0.5	0.4
Shortness of breath walking on level ground	0.2	0.2	1.7	-0.2	0.5	0.3	0.5	0.3	0.3	-1.3	-0.8	0.2	-0.3	0.1	0.5	-0.5	0.3	-0.1	0.1	0.6	-0.2
Medication: Allopurinol	0.2	0.3	3.0	-0.0	-1.7	0.5	-0.3	-0.0	-0.3	-0.4	0.4	0.5	-0.3	-0.3	-0.0	0.8	-0.1	-0.1	-0.3	0.0	0.3
Comparative height size at age 10	0.2	1.3	3.2	0.6	-1.5	-0.7	-1.1	-1.4	1.8	-1.1	-1.8	-0.6	-1.7	0.2	-0.6	0.9	-1.3	-1.2	-1.4	-0.4	0.1
Number of full sisters	0.2	0.2	1.9	-0.1	1.4	-0.2	0.5	0.0	0.0	0.4	-0.4	0.1	0.3	0.2	0.7	-0.6	0.4	0.2	0.6	0.7	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.9	-0.2	-0.6	0.1	-0.7	-0.9	-0.9	-0.7	-0.2	-0.2	-0.3	-0.8	-0.8	0.6	-0.8	-0.6	-0.7	-0.9	-0.2
Eye problems/disorders: Cataract	0.2	0.3	1.3	0.5	-0.1	1.2	0.4	0.4	0.2	-0.2	-0.6	0.7	-0.2	0.0	0.8	0.2	0.5	-0.1	-0.0	0.9	0.2
Ever taken oral contraceptive pill	0.2	0.3	1.1	0.1	0.5	0.7	-0.1	-0.7	-0.2	0.1	-0.1	-0.2	0.5	-0.7	-0.8	0.9	0.1	0.3	0.0	-1.0	0.5
Medication: Bendroflumethiazide	0.2	0.3	1.2	0.2	0.7	-1.0	0.3	0.3	1.1	0.1	-0.2	-0.1	-0.5	1.0	0.5	-0.7	-0.1	-0.1	0.0	0.7	-0.2
Major Depression (MDD)	0.1	0.1	0.4	0.1	-0.5	-0.0	-0.1	-0.1	-0.2	0.4	0.2	-0.6	-0.1	0.1	-0.6	-0.4	-0.1	-0.1	-0.1	-0.6	-0.2
HDL Cholesterol	0.1	0.1	0.5	0.1	0.7	0.7	-0.2	-0.2	-0.1	0.4	0.3	0.1	-0.1	-0.7	-0.1	0.3	-0.1	-0.2	-0.1	-0.1	0.1
Primary Biliary Cirrhosis	0.1	0.2	1.5	-0.2	0.1	-0.0	0.3	1.2	-0.2	-0.5	0.1	0.1	0.4	-0.6	0.2	0.1	-0.1	0.4	0.4	0.2	0.3
Triglycerides	0.1	0.2	1.8	0.3	1.4	0.1	-0.1	-0.3	0.4	0.7	-0.5	-0.3	-0.3	-0.5	-0.1	-0.3	0.0	-0.0	0.0	-0.1	-0.2
Blood White Count	0.1	0.7	2.1	-0.0	1.0	1.0	0.4	1.0	-0.4	1.4	1.4	0.9	0.6	-0.1	0.5	0.8	0.6	0.7	0.6	0.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	-0.7	-0.1	-0.3	-0.3	0.1	-0.7	-0.2	0.6	-0.6	0.0	-0.4	-0.5	-0.9	-0.2	-0.2	-0.1	-0.5	-0.8
Sitting height	0.1	1.0	2.6	0.2	0.8	-0.4	-1.5	-1.6	0.5	-0.8	-0.6	-0.8	-1.5	-0.3	-1.2	0.2	-1.2	-1.3	-1.4	-1.1	-0.6
Trunk fat mass	0.1	0.6	1.4	0.2	-0.9	0.8	1.0	0.6	0.4	-0.6	0.0	1.2	0.3	0.6	1.1	0.9	0.7	0.6	0.6	1.1	1.0
Waist circumference	0.1	0.3	1.4	0.3	-1.2	0.5	0.4	0.2	0.5	-0.5	-0.1	0.9	-0.2	0.3	0.7	0.8	0.2	0.2	0.1	0.8	0.7
Nervous feelings	0.1	0.3	1.5	1.1	0.2	-0.4	-0.3	0.1	1.2	0.2	-0.5	-0.0	-0.7	0.9	-0.0	0.3	-0.3	-0.2	-0.4	0.1	0.1
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	-0.4	0.3	0.2	0.2	0.4	-0.7	-0.7	-0.3	0.2	0.1	-0.5	0.2	0.0	-0.2	-0.1	0.0	0.2	0.0
Neuroticism score	0.1	0.3	1.4	0.4	0.9	-0.7	0.1	-0.0	0.8	1.2	0.1	-0.1	-0.0	0.5	-0.1	0.6	-0.2	0.2	0.1	-0.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	1.3	0.3	-0.1	-0.7	-0.2	-0.0	1.1	-0.7	-1.1	-0.5	-0.5	0.3	-0.1	-0.3	-0.4	-0.1	-0.2	0.0	-0.1
Arm fat mass (right)	0.1	0.3	1.7	-0.4	-1.2	0.1	0.2	-0.3	0.0	-1.3	-0.4	0.4	-0.4	-0.4	0.2	0.5	-0.2	-0.3	-0.2	0.3	0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	0.9	0.2	-0.0	-0.6	0.7	0.8	0.9	0.4	-0.5	-0.0	0.4	0.9	0.7	-0.5	0.4	0.7	0.7	0.7	0.4
Whole body fat mass	0.1	0.3	1.5	-0.2	-1.2	0.2	0.7	0.4	0.3	-0.8	-0.1	0.8	0.1	0.4	0.8	0.5	0.3	0.3	0.4	0.9	0.6
Leg fat mass (right)	0.1	0.3	1.5	-0.5	-1.2	0.1	0.5	0.4	-0.0	-0.9	0.1	0.5	0.3	-0.2	0.5	0.4	0.2	0.4	0.5	0.5	0.5
Knee pain experienced in last month	0.1	0.2	1.1	-0.8	-0.1	0.3	0.4	-0.3	-0.2	-1.0	-0.0	0.2	0.4	-0.4	0.2	0.4	0.2	0.3	0.4	0.1	0.4
Medication: Gliclazide	0.1	0.2	0.9	-0.2	-1.0	-0.2	-0.0	-0.4	-0.4	0.2	1.0	-0.1	0.0	-0.1	-0.3	-0.4	0.2	-0.1	-0.1	-0.3	-0.4
Arm fat mass (left)	0.1	0.4	2.4	-0.5	-1.5	-0.1	-0.1	-0.6	0.1	-1.5	-0.5	0.1	-0.6	-0.5	-0.0	0.5	-0.5	-0.5	-0.4	0.1	0.1
Medication: Atorvastatin	0.1	0.1	0.5	-0.4	-0.4	-0.4	-0.1	-0.1	-0.4	-0.7	0.1	-0.2	-0.2	-0.2	-0.2	-0.3	-0.2	-0.2	-0.1	-0.2	-0.4
Irritability	0.1	0.2	1.2	-0.6	1.1	-0.7	-0.1	0.3	0.1	-0.1	0.3	-0.2	0.2	0.8	0.2	-0.8	0.2	0.3	0.5	0.1	-0.1
Risk taking	0.1	0.2	0.5	0.6	0.7	0.6	0.1	-0.1	0.4	-0.3	-0.2	0.5	-0.6	0.2	0.3	0.4	0.0	-0.3	-0.4	0.4	0.1
Age started oral contraceptive pill	0.1	0.2	0.4	-0.5	-0.3	0.3	-0.1	-0.4	-0.6	-0.5	0.5	-0.1	0.0	-0.6	-0.5	0.5	-0.2	-0.2	-0.1	-0.6	0.1
Ever depressed for a whole week	0.1	0.1	0.7	0.3	0.6	0.2	-0.4	-0.8	0.1	0.3	0.2	-0.1	-0.3	-0.0	-0.4	0.4	-0.1	-0.3	-0.4	-0.4	0.1
Leg fat mass (left)	0.1	0.2	1.3	-0.4	-1.1	0.1	0.3	-0.0	0.2	-1.1	-0.3	0.3	-0.1	-0.3	0.3	0.5	0.1	0.0	0.1	0.4	0.4
Blood Eosinophil Count	0.0	0.3	1.4	-0.4	0.3	-0.6	0.2	-0.0	-0.1	1.2	1.0	-0.1	0.4	1.0	0.1	-0.3	0.1	0.3	0.5	-0.0	0.1
Hair Pigment	0.0	0.8	5.0	-0.7	-2.2	0.4	0.7	0.6	-1.6	-1.0	1.2	0.8	0.8	0.5	0.5	-0.4	0.6	0.4	0.7	0.4	-0.0

Hub : Genes

ERCC8

Models

Trait associations