TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Vascular/heart problems diagnosed by doctor
:
←
→
chr1:7,715,776-9,571,422
Best TWAS P=1.86e-08 · Best GWAS P=4.35e-08 conditioned to 0.252
8M
8.5M
9M
9.5M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Esophagus Mucosa
RP5-1115A15.1
0.06
0.06
lasso
4
0.05
3.0e-04
5.3
-5.6
1.9e-08
-0.88
0.04
0.90
TRUE
4
GTEx
Skin Not Sun Exposed Suprapubic
RP5-1115A15.1
0.08
0.04
enet
8
0.04
3.0e-03
5.4
-5.5
3.1e-08
-0.97
0.03
0.94
FALSE
1
GTEx
Esophagus Mucosa
RERE
0.13
0.16
lasso
3
0.16
7.2e-11
5.3
-5.3
1.0e-07
-0.86
0.03
0.97
FALSE
5
GTEx
Whole Blood
RERE
0.19
0.15
lasso
4
0.13
2.7e-12
5.3
-5.3
1.1e-07
-0.86
0.02
0.98
FALSE
3
GTEx
Lung
RP5-1115A15.1
0.05
0.08
lasso
1
0.07
1.0e-05
5.2
-5.2
2.3e-07
-0.86
0.04
0.93
FALSE