[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor : ← →

chr1:11,060,075-12,600,396

Best TWAS P=5.5e-25 · Best GWAS P=5.36e-26 conditioned to 4.4e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Cells EBV-transformed lymphocytes	MTHFR	0.33	0.12	lasso	6	0.09	7.9e-04	6.62	6.6	3.6e-11	0.80	0.33	0.29	FALSE
2	GTEx	Cells Transformed fibroblasts	CLCN6	0.08	0.02	enet	17	0.05	1.6e-04	10.54	8.0	1.3e-15	0.75	0.01	0.99	FALSE
3	GTEx	Cells Transformed fibroblasts	MTHFR	0.13	0.03	enet	30	0.05	6.8e-05	7.04	7.8	5.7e-15	0.57	0.04	0.93	FALSE
4	GTEx	Skin Not Sun Exposed Suprapubic	CLCN6	0.12	0.03	lasso	3	0.04	3.3e-03	5.61	8.8	1.7e-18	0.83	0.02	0.94	FALSE
5	GTEx	Skin Sun Exposed Lower leg	CLCN6	0.08	0.00	lasso	3	0.01	7.9e-02	3.51	6.0	1.7e-09	0.67	0.03	0.73	FALSE
6	GTEx	Spleen	CLCN6	0.21	0.10	lasso	3	0.06	1.3e-02	6.74	8.0	9.6e-16	0.86	0.04	0.70	FALSE
7	METSIM	Adipose	CLCN6	0.09	0.04	blup	480	0.06	1.6e-09	4.78	6.4	1.8e-10	0.65	0.06	0.94	FALSE
8	METSIM	Adipose	DRAXIN	0.09	0.01	enet	21	0.04	1.6e-06	0.95	-5.3	9.8e-08	-0.51	0.03	0.92	FALSE
9	NTR	Blood	AGTRAP	0.02	0.00	bslmm	484	0.00	5.2e-02	-0.37	-5.3	1.3e-07	-0.38	0.05	0.06	FALSE
10	NTR	Blood	CLCN6	0.01	0.01	lasso	2	0.01	3.0e-04	6.77	5.4	6.7e-08	0.78	0.38	0.53	TRUE
11	NTR	Blood	MTHFR	0.09	0.07	enet	17	0.10	4.4e-31	3.51	7.0	2.1e-12	0.66	1.00	0.00	FALSE
12	YFS	Blood	MTHFR	0.50	0.49	enet	40	0.62	5.5e-264	3.51	5.6	1.8e-08	0.52	1.00	0.00	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	CLCN6	0.06	0.06	blup	104	0.06	5.0e-12	7.37	10.2	1.4e-24	0.75	0.22	0.78	FALSE
14	The Cancer Genome Atlas	Colon Adenocarcinoma	CLCN6	0.14	0.05	blup	104	0.09	1.2e-05	10.31	7.2	5.2e-13	0.81	0.01	0.98	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	MTHFR	0.07	0.01	blup	92	0.04	2.9e-03	0.39	6.9	4.3e-12	0.76	0.04	0.47	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	NPPA	0.06	0.01	lasso	5	0.01	1.3e-01	3.47	-5.4	6.1e-08	-0.34	0.04	0.24	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CLCN6	0.04	0.06	lasso	2	0.05	1.1e-06	7.37	8.4	3.5e-17	0.69	0.10	0.89	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CLCN6	0.05	0.05	lasso	6	0.05	9.2e-07	3.51	6.3	3.3e-10	0.51	0.50	0.47	FALSE
19	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CLCN6	0.07	0.00	blup	104	0.03	7.9e-03	-2.46	5.9	3.0e-09	0.60	0.06	0.28	FALSE
20	The Cancer Genome Atlas	Lung Adenocarcinoma	CLCN6	0.06	0.04	blup	104	0.04	5.2e-06	10.54	10.3	5.5e-25	0.91	0.01	0.99	TRUE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	CLCN6	0.10	0.07	blup	104	0.07	3.9e-08	7.84	10.0	1.1e-23	0.59	0.20	0.80	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	CLCN6	0.07	0.04	blup	104	0.05	2.4e-04	10.31	9.6	6.1e-22	0.94	0.01	0.98	FALSE
23	The Cancer Genome Atlas	Stomach Adenocarcinoma	NPPA	0.06	0.03	enet	4	0.04	7.6e-04	7.84	-6.1	8.3e-10	-0.45	0.11	0.15	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	CLCN6	0.08	0.02	blup	104	0.05	2.5e-05	4.88	7.3	2.8e-13	0.64	0.15	0.84	FALSE