Best TWAS P=5.3e-09 · Best GWAS P=2.74e-08 conditioned to 0.194
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | TP53INP1 | 0.08 | 0.02 | enet | 18 | 0.03 | 9.7e-03 | 4.6 | -5.2 | 2.4e-07 | 0.61 | 0.07 | 0.81 | FALSE |
| 2 | GTEx | Brain Cerebellum | NDUFAF6 | 0.28 | 0.13 | lasso | 7 | 0.14 | 5.8e-05 | -5.3 | 5.1 | 3.0e-07 | -0.95 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | NDUFAF6 | 0.07 | 0.03 | enet | 9 | 0.01 | 7.6e-02 | -5.3 | 5.8 | 5.3e-09 | -0.83 | 0.03 | 0.94 | TRUE |
| 4 | YFS | Blood | TP53INP1 | 0.03 | 0.02 | lasso | 5 | 0.02 | 8.0e-07 | -3.6 | -5.1 | 3.1e-07 | 0.82 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C8orf38 | 0.02 | 0.00 | blup | 127 | 0.01 | 4.0e-04 | -3.4 | 5.2 | 1.6e-07 | -0.56 | 0.14 | 0.16 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TP53INP1 | 0.04 | 0.05 | blup | 56 | 0.06 | 4.2e-07 | -5.3 | -5.6 | 1.8e-08 | 0.95 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TP53INP1 | 0.06 | 0.02 | lasso | 3 | 0.03 | 2.8e-03 | -5.3 | -5.3 | 1.1e-07 | 0.96 | 0.01 | 0.95 | FALSE |