Best TWAS P=5.73e-12 · Best GWAS P=3.76e-12 conditioned to 6.94e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | SIPA1 | 0.19 | 0.00 | enet | 30 | 0.05 | 2.5e-04 | -4.1 | -5.3 | 1.4e-07 | -0.48 | 0.05 | 0.80 | FALSE |
| 2 | GTEx | Nerve Tibial | SIPA1 | 0.17 | 0.01 | enet | 19 | 0.06 | 6.8e-05 | 5.6 | -6.4 | 1.6e-10 | -0.42 | 0.08 | 0.76 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | CTSW | 0.06 | 0.03 | bslmm | 328 | 0.03 | 3.6e-05 | -2.8 | 5.9 | 3.7e-09 | 0.45 | 0.46 | 0.25 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RNASEH2C | 0.05 | 0.00 | blup | 32 | 0.02 | 1.1e-04 | -1.7 | 6.9 | 5.7e-12 | 0.41 | 0.00 | 0.89 | TRUE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SIPA1 | 0.06 | 0.04 | blup | 43 | 0.05 | 4.6e-06 | 4.0 | -5.7 | 1.1e-08 | -0.52 | 0.02 | 0.95 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RNASEH2C | 0.15 | 0.05 | blup | 32 | 0.05 | 3.1e-06 | -1.7 | 5.8 | 6.4e-09 | 0.47 | 0.55 | 0.03 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SIPA1 | 0.04 | 0.00 | blup | 43 | 0.02 | 6.2e-03 | 5.5 | -5.7 | 1.3e-08 | -0.59 | 0.00 | 0.46 | FALSE |