[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor : ← →

chr15:67,138,238-68,789,191

Best TWAS P=1.02e-08 · Best GWAS P=1.21e-08 conditioned to 0.24

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Muscle Skeletal	MAP2K5	0.08	0.03	lasso	6	0.05	1.9e-05	-4.7	-5.7	1.0e-08	-0.91	0.01	0.99	TRUE
6	GTEx	Heart Atrial Appendage	MAP2K5	0.16	0.08	lasso	5	0.16	1.3e-07	5.1	-5.7	1.0e-08	-0.80	0.05	0.95	FALSE
4	GTEx	Brain Cerebellum	MAP2K5	0.27	0.12	lasso	5	0.14	7.9e-05	4.2	-5.4	5.3e-08	-0.54	0.24	0.52	FALSE
11	GTEx	Ovary	MAP2K5	0.19	0.24	lasso	3	0.21	8.3e-06	5.3	-5.4	5.3e-08	-0.65	0.08	0.80	FALSE
12	GTEx	Skin Sun Exposed Lower leg	MAP2K5	0.13	0.06	lasso	4	0.09	4.4e-08	-4.3	-5.4	7.1e-08	-0.73	0.23	0.77	FALSE
2	GTEx	Adipose Visceral Omentum	MAP2K5	0.07	0.08	lasso	3	0.05	1.0e-03	5.4	-5.4	8.2e-08	-0.65	0.09	0.85	FALSE
3	GTEx	Artery Tibial	MAP2K5	0.15	0.18	lasso	3	0.18	6.3e-14	5.2	-5.3	8.7e-08	-0.65	0.06	0.94	FALSE
7	GTEx	Heart Left Ventricle	MAP2K5	0.10	0.10	lasso	3	0.10	9.4e-06	5.3	-5.3	1.0e-07	-0.65	0.06	0.93	FALSE
5	GTEx	Esophagus Muscularis	MAP2K5	0.24	0.14	lasso	4	0.13	2.1e-08	5.2	-5.3	1.1e-07	-0.65	0.06	0.94	FALSE
13	GTEx	Thyroid	MAP2K5	0.11	0.16	lasso	4	0.15	9.6e-12	5.3	-5.3	1.1e-07	-0.68	0.05	0.94	FALSE
1	GTEx	Adipose Subcutaneous	MAP2K5	0.14	0.18	lasso	4	0.18	1.0e-14	5.3	-5.2	1.5e-07	-0.65	0.06	0.94	FALSE
16	The Cancer Genome Atlas	Thyroid Carcinoma	MAP2K5	0.10	0.06	lasso	5	0.04	6.1e-05	5.2	-5.2	1.5e-07	-0.64	0.08	0.91	FALSE
10	GTEx	Nerve Tibial	MAP2K5	0.19	0.21	lasso	2	0.20	3.3e-14	5.2	-5.2	1.9e-07	-0.66	0.07	0.93	FALSE
15	The Cancer Genome Atlas	Lung Adenocarcinoma	MAP2K5	0.04	0.04	lasso	3	0.03	8.7e-05	5.2	-5.2	1.9e-07	-0.66	0.09	0.89	FALSE
8	GTEx	Lung	MAP2K5	0.12	0.09	enet	11	0.07	3.6e-06	5.1	-5.2	2.1e-07	-0.60	0.06	0.94	FALSE
14	YFS	Blood	MAP2K5	0.05	0.07	lasso	4	0.07	1.2e-21	5.3	-5.2	2.4e-07	-0.63	0.08	0.92	FALSE