Best TWAS P=5.36e-12 · Best GWAS P=8.92e-12 conditioned to 0.169
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EXD1 | 0.04 | 0.04 | lasso | 3 | 0.04 | 8.1e-06 | -6.4 | 6.3 | 2.7e-10 | -0.94 | 0.04 | 0.95 | FALSE |
| 2 | GTEx | Brain Cortex | GCHFR | 0.25 | 0.04 | enet | 15 | 0.05 | 1.4e-02 | -5.5 | 5.5 | 4.0e-08 | -0.77 | 0.04 | 0.71 | FALSE |
| 3 | GTEx | Colon Sigmoid | NDUFAF1 | 0.15 | 0.06 | lasso | 4 | 0.06 | 5.2e-03 | -5.3 | 6.1 | 1.3e-09 | -0.70 | 0.16 | 0.60 | FALSE |
| 4 | GTEx | Esophagus Mucosa | CHP1 | 0.19 | 0.10 | lasso | 7 | 0.09 | 1.4e-06 | -5.8 | 6.0 | 2.2e-09 | -0.94 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Lung | OIP5-AS1 | 0.09 | 0.08 | enet | 14 | 0.12 | 2.8e-09 | -6.6 | -5.8 | 4.9e-09 | 0.88 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | NDUFAF1 | 0.16 | 0.06 | lasso | 3 | 0.07 | 1.7e-04 | -5.3 | 5.4 | 7.4e-08 | -0.50 | 0.09 | 0.12 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | CHP1 | 0.06 | 0.04 | enet | 9 | 0.04 | 3.1e-04 | -6.6 | 6.9 | 5.4e-12 | -0.90 | 0.02 | 0.95 | TRUE |
| 8 | NTR | Blood | INO80 | 0.02 | 0.02 | enet | 8 | 0.03 | 2.8e-09 | -5.6 | 5.8 | 6.2e-09 | -0.84 | 0.49 | 0.51 | FALSE |
| 9 | YFS | Blood | MGA | 0.01 | 0.00 | blup | 454 | 0.00 | 7.1e-02 | -5.9 | -5.7 | 1.4e-08 | 0.69 | 0.02 | 0.82 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CHP | 0.01 | 0.01 | blup | 54 | 0.01 | 1.4e-02 | -6.8 | 6.2 | 4.4e-10 | -0.92 | 0.01 | 0.90 | FALSE |
| 11 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | INO80 | 0.07 | 0.04 | blup | 40 | 0.06 | 1.2e-03 | -4.4 | -5.2 | 1.8e-07 | 0.80 | 0.03 | 0.66 | FALSE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | INO80 | 0.03 | 0.02 | blup | 39 | 0.03 | 1.0e-03 | -2.2 | -5.2 | 2.0e-07 | 0.78 | 0.06 | 0.85 | FALSE |