Best TWAS P=2.99e-11 · Best GWAS P=1.1e-08 conditioned to 1.28e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | AC006111.1 | 0.18 | 0.12 | enet | 12 | 0.10 | 1.1e-05 | -3.6 | -5.4 | 8.7e-08 | 0.02 | 0.58 | 0.07 | FALSE |
| 2 | GTEx | Brain Cortex | AC006111.1 | 0.32 | 0.02 | enet | 16 | 0.00 | 3.2e-01 | 3.5 | -5.4 | 8.4e-08 | -0.04 | 0.04 | 0.10 | TRUE |
| 3 | GTEx | Heart Atrial Appendage | MGRN1 | 0.33 | 0.30 | enet | 13 | 0.32 | 7.1e-15 | 3.7 | -5.5 | 3.3e-08 | -0.19 | 0.86 | 0.08 | FALSE |
| 4 | GTEx | Heart Left Ventricle | MGRN1 | 0.32 | 0.10 | enet | 18 | 0.33 | 3.6e-18 | -4.2 | -6.6 | 3.0e-11 | -0.20 | 0.76 | 0.18 | TRUE |
| 5 | GTEx | Muscle Skeletal | MGRN1 | 0.16 | 0.06 | lasso | 7 | 0.15 | 1.1e-14 | -4.4 | -6.3 | 2.6e-10 | -0.18 | 0.53 | 0.43 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | AC006111.1 | 0.19 | 0.12 | enet | 13 | 0.18 | 2.1e-10 | 2.7 | -5.4 | 7.9e-08 | 0.02 | 0.10 | 0.88 | TRUE |
| 7 | METSIM | Adipose | NUDT16L1 | 0.06 | 0.03 | bslmm | 392 | 0.04 | 2.2e-06 | 3.6 | 6.0 | 2.6e-09 | 0.33 | 0.39 | 0.58 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | NAT15 | 0.06 | 0.04 | blup | 56 | 0.04 | 4.1e-05 | -4.6 | 5.2 | 2.3e-07 | -0.01 | 0.12 | 0.70 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NAT15 | 0.04 | 0.01 | blup | 56 | 0.04 | 4.2e-05 | -4.8 | 5.3 | 1.1e-07 | -0.05 | 0.03 | 0.90 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | NAT15 | 0.10 | 0.05 | lasso | 6 | 0.07 | 6.1e-07 | -5.4 | 5.3 | 1.2e-07 | -0.04 | 0.01 | 0.99 | FALSE |