Best TWAS P=1.06e-08 · Best GWAS P=8.98e-09 conditioned to 0.23
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | MRAS | 0.52 | 0.53 | lasso | 5 | 0.54 | 2.5e-34 | 5.6 | 5.6 | 2.4e-08 | 0.95 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Coronary | MRAS | 0.32 | 0.10 | lasso | 4 | 0.12 | 7.4e-05 | 5.6 | 5.5 | 3.6e-08 | 0.91 | 0.02 | 0.96 | FALSE |
| 3 | GTEx | Artery Tibial | MRAS | 0.24 | 0.20 | enet | 7 | 0.20 | 2.3e-15 | 5.6 | 5.4 | 6.3e-08 | 0.93 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Brain Frontal Cortex BA9 | DBR1 | 0.18 | 0.10 | lasso | 5 | 0.11 | 9.7e-04 | 5.6 | 5.7 | 1.1e-08 | 0.93 | 0.03 | 0.88 | TRUE |
| 5 | GTEx | Testis | MRAS | 0.20 | 0.14 | lasso | 4 | 0.11 | 1.2e-05 | 4.8 | -5.3 | 1.0e-07 | -0.64 | 0.08 | 0.88 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MRAS | 0.03 | 0.01 | blup | 49 | 0.01 | 9.6e-03 | 4.8 | -5.7 | 1.6e-08 | -0.69 | 0.04 | 0.70 | FALSE |
| 7 | The Cancer Genome Atlas | Soft Tissue Sarcoma | MRAS | 0.04 | 0.03 | blup | 49 | 0.04 | 1.8e-03 | 4.9 | 5.6 | 2.3e-08 | 0.63 | 0.05 | 0.57 | FALSE |