Hub : Genes

MRAS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.5250	0.0650	0.0e+00	0.529	NA	0.519	NA	0.535	8.8e-34	NA	6.5e-33	NA	2.5e-34
2	GTEx	Artery Coronary	0.3170	0.1020	1.4e-03	0.102	NA	0.067	NA	0.121	2.6e-04	NA	2.8e-03	NA	7.4e-05
3	GTEx	Artery Tibial	0.2369	0.0634	5.8e-09	0.201	NA	0.197	NA	0.194	1.1e-15	NA	2.3e-15	NA	3.8e-15
4	GTEx	Testis	0.2010	0.0880	1.1e-03	0.141	NA	0.070	NA	0.112	8.0e-07	NA	5.0e-04	NA	1.1e-05
5	METSIM	Adipose	0.0414	0.0221	8.3e-03	0.013	0.010	0.030	0.011	0.018	3.6e-03	8.9e-03	1.9e-05	0.0064	7.3e-04
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0881	0.0428	6.2e-08	0.084	0.075	0.081	NA	0.086	1.1e-09	8.7e-09	2.0e-09	NA	7.2e-10
7	TCGA	Brain Lower Grade Glioma	0.0262	0.0179	2.6e-03	0.005	0.014	0.003	NA	0.002	7.2e-02	9.6e-03	1.2e-01	NA	1.6e-01
8	TCGA	Soft Tissue Sarcoma	0.0420	0.0270	2.4e-03	0.028	0.041	0.030	NA	0.029	8.6e-03	1.8e-03	6.6e-03	NA	7.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	1.2	1.9	6.4	-0.1	-0.5	0.0	-1.4	1.3	-2.5	-1.6	1.5
Bipolar Disorder or Schizophrenia	1.7	4.2	9.6	0.8	0.8	0.8	-2.6	0.9	-3.1	-2.8	2.6
Depressed Affect (Nagel 2018)	0.8	1.8	4.7	0.3	0.1	0.6	-1.5	1.3	-2.2	-1.6	1.6
Depression (Nagel 2018)	0.1	0.2	1.5	0.1	-0.3	-0.3	0.1	-1.2	-0.1	-0.2	-0.0
Intelligence (Savage-Jansen 2018)	3.3	10.1	18.8	2.4	2.8	2.8	-4.0	-0.0	-3.3	-3.8	4.3
Neuroticism (Nagel 2018)	0.7	1.6	3.5	-0.1	0.3	0.5	-1.4	1.7	-1.9	-1.5	1.4
Schizophrenia (2018)	1.3	2.8	5.0	1.1	1.4	1.0	-2.2	0.1	-1.9	-2.2	2.2
Schizophrenia vs Biploar Disorder	0.2	0.3	1.2	0.1	0.1	0.1	0.4	0.2	1.1	0.5	-0.6
Worry (Nagel 2018)	0.3	0.6	1.3	-0.2	0.4	0.2	-0.7	1.2	-1.1	-1.0	0.8
Alzheimer’s Disease (in mother)	0.8	0.9	1.9	1.0	1.1	0.9	-1.1	0.0	-0.6	-1.4	1.0
Alzheimer’s Disease (in father)	0.6	0.7	1.4	0.4	0.6	0.7	-1.1	1.2	-0.8	-0.9	0.7
Alzheimer’s Disease (including proxy)	0.5	0.7	1.8	0.5	0.8	0.7	-1.0	-0.3	-0.6	-1.3	0.8
Crohns Disease (2017)	0.4	1.0	3.2	-0.9	-1.8	-1.1	0.9	0.1	0.1	0.9	-1.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	0.4	-0.3	0.6	0.4	-0.1	0.5	0.3	-0.5
Ulcerative Colitis (UC)	0.4	0.7	2.4	1.2	0.9	1.6	-0.3	-0.4	0.5	-0.4	0.2
Major Depression (MDD)	0.7	0.9	1.4	-1.2	-1.0	-1.1	0.9	-0.1	0.5	1.1	-1.1
Reaction Time	0.1	0.2	0.8	-0.1	-0.9	-0.1	-0.4	-0.6	-0.6	-0.2	0.1
Verbal and Numeric Reasoning (VNR)	2.5	6.1	13.6	0.7	1.0	0.9	-3.2	0.8	-3.7	-3.0	3.6
Breast Cancer	0.2	0.5	1.4	0.1	0.3	0.6	-0.7	1.2	-0.7	-0.6	0.6
Ovarian Cancer	0.2	0.2	0.9	0.4	0.3	0.4	0.1	-1.0	0.5	0.1	-0.3
Prostate Cancer	0.2	0.2	0.4	-0.3	0.4	-0.3	-0.5	-0.6	-0.5	-0.5	0.5
Age at First Birth	2.3	3.3	5.7	-1.6	-1.2	-1.8	2.4	0.0	1.8	2.1	-2.3
Bipolar Disorder (2011)	0.4	0.4	0.9	0.3	0.1	0.5	-0.8	-0.1	-0.9	-0.8	0.8
Body Mass Index (BMI) (2010)	1.5	2.1	7.9	-0.6	-0.4	-0.4	-1.3	2.8	-1.9	-1.1	1.4
Coronary Artery Disease (CAD)	15.2	18.1	30.1	5.2	5.5	5.0	-4.3	-0.9	-1.7	-4.7	4.2
Crohns Disease (2012)	0.8	1.2	3.3	-1.0	-1.8	-1.2	1.0	0.2	0.2	1.3	-1.0
Mean Putamen Volume	0.1	0.1	0.3	0.3	0.3	0.6	-0.1	0.6	0.5	0.0	-0.2
Fasting Glucose	1.2	1.4	2.6	0.3	0.8	0.7	-1.6	1.2	-1.5	-1.3	1.6
HbA1C	0.9	1.1	2.4	1.3	0.7	0.9	-1.3	-0.1	-0.8	-1.5	0.9
HDL Cholesterol	0.6	1.0	4.6	-0.4	-0.3	-0.5	0.8	-2.1	0.9	1.0	-0.7
LDL Cholesterol	0.3	0.5	1.9	1.1	0.5	0.6	0.1	-1.4	0.6	0.0	-0.1
Lupus	0.2	0.3	1.4	0.1	0.5	0.3	0.5	0.1	1.2	0.6	-0.5
Neuroticism (2016)	0.3	0.4	1.7	-0.5	-0.5	-0.4	-0.2	-0.3	-1.3	-0.6	0.5
Primary Biliary Cirrhosis	3.9	5.5	9.9	1.7	1.8	1.8	-2.7	0.5	-2.8	-3.0	3.1
Rheumatoid Arthritis	0.0	0.0	0.1	-0.2	-0.1	-0.2	0.1	-0.3	0.3	0.1	-0.3
Schizophrenia (2014)	1.0	2.3	3.8	1.2	1.0	1.1	-1.8	0.7	-1.8	-2.0	1.9
Triglycerides	1.1	1.8	2.8	0.9	0.7	1.2	-1.6	1.0	-1.7	-1.6	1.6
Type 2 Diabetes (T2D) (2012)	2.9	3.3	5.8	1.2	1.4	1.3	-2.3	0.6	-2.1	-2.3	2.4
Ulcerative Colitis	0.5	0.8	1.8	1.0	1.0	1.4	-0.9	0.8	-0.1	-0.8	0.6
Blood Eosinophil Count	0.4	3.2	6.4	-1.0	-0.2	-1.1	2.3	-1.5	2.5	2.0	-2.4
Blood Platelet Count	0.4	4.8	10.4	-0.8	-0.6	-1.2	2.5	-3.2	2.9	2.3	-2.4
Blood Red Count	0.5	4.8	12.5	-0.3	-0.3	-0.9	3.0	-0.2	3.5	2.6	-2.9
Blood White Count	0.1	0.7	1.9	1.1	0.6	1.3	-0.1	-1.4	0.2	-0.6	0.4
Heel T-Score	1.6	13.1	20.4	-3.1	-3.3	-3.7	4.5	0.6	3.2	4.3	-4.5
BMI	1.3	7.8	19.5	-4.4	-3.9	-4.3	0.3	1.4	-2.6	0.8	0.1
Height	0.9	18.1	27.9	-4.1	-4.0	-4.1	5.0	-0.2	3.8	5.2	-5.3
Waist Hip Ratio (WHR)	8.1	36.3	67.1	8.2	7.9	7.9	-5.7	-0.9	-1.3	-6.0	5.2
Systolic Blood Pressure	4.7	23.7	45.2	6.4	5.8	6.7	-4.6	-1.0	-1.7	-4.9	4.6
Smoking Status	0.4	1.1	3.3	-0.8	-1.1	-0.8	-0.8	1.0	-1.8	-0.7	0.8
Allergy or Eczema	0.1	0.4	0.6	-0.7	-0.6	-0.5	0.7	0.5	0.2	0.6	-0.7
Cardiovascular Disease	8.6	28.5	37.0	6.0	6.0	6.0	-5.8	-1.8	-3.3	-6.1	5.9
Hypothyroidism (self reported)	0.3	0.6	1.7	0.9	1.2	1.3	0.1	-0.6	0.6	-0.4	0.2
Respiratory disease	1.1	2.4	4.4	1.2	1.1	1.4	-2.1	0.8	-1.4	-2.1	1.7
Type 2 Diabetes (T2D) (2018)	10.5	19.7	30.6	4.3	4.3	3.9	-5.3	-1.8	-3.9	-5.5	5.3
Lung FEV1/FVC ratio	0.7	3.7	9.0	1.1	0.8	0.4	-2.3	-1.0	-3.0	-2.1	2.8
Lung FVC	4.3	21.7	37.2	-3.2	-2.8	-3.6	6.1	-1.4	5.8	5.8	-6.1
Neuroticism	1.0	2.3	7.8	-0.8	-0.9	-0.5	-1.5	1.4	-2.8	-1.5	1.6
Chronotype (morning person)	3.4	7.9	16.6	-1.1	-0.9	-1.7	3.8	-1.0	4.1	3.4	-3.8
Hair Pigment	1.0	28.5	53.0	3.4	3.5	3.2	-7.0	1.5	-6.8	-6.6	7.3
Tanning	0.2	2.8	6.2	-0.9	-1.0	-0.9	2.1	-0.5	2.3	2.5	-2.0
Hand grip strength (left)	0.9	2.2	3.3	-1.5	-0.8	-1.8	1.8	-0.6	1.4	1.8	-1.7
Number of treatments/medications taken	5.4	9.8	14.5	3.8	3.3	3.7	-3.1	-1.4	-1.8	-3.8	3.3
Average weekly spirits intake	0.8	1.0	2.5	-1.1	-1.3	-1.2	-0.2	0.4	-1.6	-0.4	0.4
Sensitivity / hurt feelings	0.9	1.5	2.8	-1.7	-1.5	-1.3	1.1	1.4	0.1	1.1	-1.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.5	-0.7	-0.9	-0.9	0.6	-1.6	0.0	0.5	-0.5
Hearing difficulty/problems: Yes	2.7	4.1	9.0	0.2	0.4	0.5	-2.4	2.3	-3.0	-2.4	2.5
Relative age of first facial hair	0.2	0.5	1.2	0.4	0.3	0.9	-1.1	0.3	-0.8	-0.5	0.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.1	1.3	1.2	1.8	-0.9	-0.1	-0.1	-1.1	0.8
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.0	1.1	0.7	0.3	0.7	-1.7	1.3	0.2	-0.5
Ever had hysterectomy (womb removed)	0.2	0.3	0.6	0.6	0.4	0.6	0.4	0.5	0.8	0.2	-0.5
Systolic blood pressure, automated reading	3.5	10.0	17.4	4.0	3.6	4.2	-3.2	-0.1	-1.4	-3.3	3.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.4	0.8	0.7	0.3	-1.4	0.4	-1.3	-1.2	1.5
Angina	2.2	2.8	5.4	2.2	2.1	2.3	-1.2	-1.7	-0.2	-1.4	1.4
Medication for hormone replacement therapy	0.4	0.5	0.9	-0.1	-0.2	-0.6	0.9	0.6	0.9	0.8	-0.9
Vitamin and mineral supplements	1.4	1.8	3.0	0.7	1.2	1.1	-1.6	1.6	-1.2	-1.5	1.7
Supplements: Zinc	0.5	0.6	2.1	0.6	0.9	0.5	-0.5	-1.5	-0.2	-0.8	0.4
Medication: Co-codamol	0.7	0.8	2.3	0.5	1.5	0.2	-1.0	-0.8	-0.4	-0.8	1.2
Medication: Metformin	9.6	13.5	20.9	3.6	3.0	3.1	-4.5	-0.5	-3.8	-4.6	4.5
Diabetes (father)	0.4	0.5	3.6	0.3	-0.0	-0.2	-0.2	-1.9	-0.3	-0.1	0.1
Diabetes (mother)	3.2	4.1	7.7	1.4	0.9	1.5	-2.8	0.5	-2.6	-2.6	2.5
Severe depression (siblings)	0.0	0.0	0.2	0.0	0.2	0.0	-0.4	0.1	-0.1	-0.2	0.2
Pack years adult smoking proportion	0.5	0.7	1.8	0.6	1.0	0.7	-0.9	-1.3	-0.3	-0.5	0.8
Impedance of leg (right)	0.4	2.1	5.7	0.5	1.0	0.4	1.4	-1.9	2.4	1.3	-1.5
Leg fat-free mass (left)	1.1	5.8	13.8	-3.7	-3.6	-3.5	1.2	0.9	-0.9	1.7	-1.1
Trunk fat percentage	2.5	10.0	21.3	-4.6	-4.1	-4.6	2.6	0.7	0.2	2.9	-2.4
Hand grip strength (right)	1.5	4.1	6.5	-2.3	-1.5	-2.5	2.4	-1.0	1.5	2.2	-2.3
Townsend deprivation index at recruitment	0.0	0.1	0.2	0.0	-0.1	0.3	-0.2	-0.4	0.0	-0.2	-0.0
Current tobacco smoking	0.7	1.1	2.4	-1.5	-1.6	-1.2	-0.3	1.0	-1.2	0.1	0.1
Average weekly fortified wine intake	0.8	0.9	2.1	-1.0	-0.8	-0.9	0.9	-1.5	0.3	0.9	-0.9
Maternal smoking around birth	0.4	0.6	1.6	1.0	0.8	1.2	0.0	-0.8	0.9	-0.2	-0.1
Fed-up feelings	0.7	1.3	4.2	-0.2	-0.5	0.2	-1.3	1.0	-2.1	-1.0	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.6	-0.6	-0.8	-0.7	0.8	-1.3	0.3	0.7	-0.6
Relative age voice broke	0.5	0.8	2.7	-0.5	-0.3	-0.1	-0.7	1.6	-1.3	-0.3	1.0
Taking other prescription medications	6.5	10.0	15.5	3.5	3.4	3.9	-3.4	-0.3	-1.8	-3.9	3.3
Age when periods started (menarche)	1.1	2.6	4.0	-1.6	-2.0	-1.8	1.5	-0.7	1.0	2.0	-1.9
Bilateral oophorectomy (both ovaries removed)	2.6	3.0	8.0	1.7	1.9	1.3	0.9	-2.8	2.5	0.4	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	6.4	-1.6	-1.1	-1.6	2.4	1.7	2.2	2.3	-2.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.1	0.0	-0.0	-0.5	-0.2	-0.4	-0.6	0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.4	-0.6	-0.3	-0.5	-0.3	-0.0	-0.0	0.6	0.0
Serious illness, injury or assault to yourself	2.1	2.6	4.6	2.1	2.1	1.7	-1.5	-1.8	-0.1	-1.5	1.1
High blood pressure	8.6	24.1	31.9	5.6	5.5	5.4	-5.3	0.2	-3.2	-5.7	5.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	-0.6	-0.3	-0.5	0.7	0.3	0.4	0.6	-0.8
Multivitamins +/- minerals	2.2	2.8	5.8	-0.5	-0.9	-0.9	2.0	-2.4	1.9	1.6	-2.1
Stomach or abdominal pain in last month	0.3	0.4	2.4	-0.5	-0.3	-0.5	0.4	-1.6	0.0	-0.4	-0.4
Supplements: Glucosamine	0.1	0.1	0.2	-0.0	-0.3	-0.4	0.4	-0.3	-0.2	0.3	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	-0.4	-0.4	-0.3	-0.0	-0.4	-0.6	-0.3	0.3
Medication: Atenolol	4.7	5.8	10.3	2.2	2.4	2.5	-3.0	-0.2	-2.2	-2.5	3.2
Medication: Levothyroxine sodium	0.4	0.7	1.6	1.1	1.2	1.3	-0.3	-0.2	0.6	-0.8	0.2
Sitting height	1.4	10.0	16.2	-2.7	-2.3	-3.1	3.7	-2.4	3.0	4.0	-3.6
Chronic bronchitis/emphysema (father)	4.2	4.9	10.5	-1.1	-0.9	-1.0	3.0	0.0	3.2	2.6	-3.1
High blood pressure (mother)	7.9	11.1	15.4	3.5	3.9	3.5	-3.8	-0.6	-2.0	-3.9	3.8
Body mass index (BMI)	1.1	4.7	11.2	-3.4	-3.0	-3.2	0.1	1.6	-2.1	0.7	0.1
Impedance of leg (left)	0.5	2.6	7.8	0.5	1.2	0.4	1.6	-1.7	2.8	1.5	-1.8
Leg predicted mass (left)	1.1	5.9	13.9	-3.7	-3.6	-3.5	1.3	0.9	-0.8	1.8	-1.1
Trunk fat mass	2.4	10.5	23.2	-4.8	-4.3	-4.8	2.4	0.8	-0.2	2.8	-2.2
Waist circumference	0.8	2.8	7.9	-0.3	0.0	-0.2	-2.2	1.3	-2.8	-1.8	2.3
Number of incorrect matches in round	5.1	8.5	14.9	-3.5	-3.8	-3.9	3.0	-0.3	1.0	2.9	-2.7
Past tobacco smoking	0.2	0.3	1.0	0.2	1.0	0.6	-0.5	-0.7	0.3	-0.2	0.5
Alcohol usually taken with meals	5.5	9.0	18.1	-1.7	-1.7	-2.1	4.3	-0.5	3.8	3.8	-3.8
Nervous feelings	1.3	2.4	4.3	1.2	1.4	1.8	-1.8	-0.2	-1.4	-2.1	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.4	-1.2	-1.1	-1.1	0.9	-0.2	0.2	0.9	-0.8
Hearing difficulty/problems with background noise	1.7	2.8	7.4	-0.7	-0.7	-0.4	-1.5	2.4	-2.7	-1.4	1.8
Hair/balding pattern: Pattern 2	0.5	0.7	1.3	-0.0	0.8	-0.6	-0.9	1.2	-0.9	-0.6	1.1
Had menopause	1.9	2.4	5.9	-0.3	-0.7	-0.6	2.1	0.4	2.4	1.8	-2.1
Had other major operations	0.3	0.4	1.8	0.1	0.1	0.3	0.3	1.3	0.9	0.5	-0.5
Forced vital capacity (FVC)	3.1	12.0	19.0	-2.9	-1.9	-3.1	4.1	-1.5	4.2	4.4	-4.3
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.7	9.1	-1.9	-2.1	-2.0	3.0	1.4	2.1	3.0	-3.0
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.5	1.1	1.1	0.9	-1.3	-0.8	-1.2	-1.3	1.6
Qualifications: None of the above	0.2	0.4	1.1	-0.4	-1.1	-0.4	0.6	0.6	0.2	0.3	-0.7
Financial difficulties in last 2 years	1.5	2.1	5.0	1.8	2.2	1.9	-0.4	-1.7	1.2	-0.2	0.4
Mouth/teeth dental problems	0.2	0.3	1.0	-0.2	-0.1	-0.4	0.6	-1.0	0.5	0.6	-0.5
Heart attack	5.7	7.3	14.6	3.8	3.7	3.7	-1.9	-2.2	0.6	-2.2	1.7
Allergy	0.8	1.8	3.3	-1.7	-1.8	-1.7	1.3	-0.1	0.6	1.4	-1.1
Pain all over the body in last month	0.3	0.3	1.6	0.2	0.2	0.8	-0.1	-1.3	-0.2	0.0	0.4
Diabetes (self-reported)	6.4	9.9	15.2	3.3	3.0	2.7	-3.8	-1.2	-2.8	-3.9	3.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.4	-1.1	-0.2	-0.6	1.0	0.1	0.8	1.2	-0.8
Medication: Ramipril	9.1	11.7	17.7	3.5	3.4	3.4	-4.2	0.4	-2.6	-4.2	4.0
Medication: Simvastatin	6.4	9.3	13.0	3.5	3.5	3.6	-3.3	-0.0	-1.8	-3.5	3.2
Fluid intelligence score	2.9	6.1	13.3	1.0	1.1	1.1	-3.1	1.0	-3.7	-2.9	3.5
Illnesses of siblings	3.3	4.6	8.2	-2.9	-2.5	-2.3	2.4	0.3	0.9	2.3	-2.2
Neuroticism score	0.5	1.0	3.3	-0.5	-0.2	0.1	-1.1	0.9	-1.8	-1.0	1.3
Weight	1.4	7.1	17.6	-4.2	-3.7	-4.1	1.3	1.0	-1.0	2.0	-1.1
Impedance of arm (right)	0.2	0.9	3.1	0.8	0.5	0.9	0.9	-0.3	1.8	0.5	-1.2
Arm fat percentage (right)	1.3	5.2	12.6	-3.6	-3.3	-3.4	0.9	1.4	-1.3	1.3	-0.7
Trunk fat-free mass	0.5	2.6	6.5	-2.5	-2.3	-2.5	0.7	0.6	-0.5	1.3	-0.8
Hip circumference	2.2	9.3	22.6	-4.8	-4.2	-4.5	1.0	2.5	-1.9	1.7	-0.7
Time employed in main current job	1.0	1.2	3.0	-1.7	-1.4	-1.7	0.7	-0.3	-0.3	0.5	-0.7
Alcohol intake versus 10 years previously	0.2	0.3	0.7	-0.5	-0.0	-0.2	-0.6	0.6	-0.8	-0.5	0.5
Father’s age at death	4.0	5.4	7.9	-1.8	-2.0	-2.8	2.6	-0.5	2.4	2.7	-2.8
Worrier / anxious feelings	0.0	0.1	0.4	0.2	0.6	0.3	-0.1	0.4	0.1	-0.0	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	3.3	-0.2	0.6	0.2	0.4	-1.8	0.8	0.4	-0.3
Falls in the last year	3.0	4.0	7.6	1.5	1.6	1.8	-2.5	0.5	-2.3	-2.1	2.8
Hair/balding pattern: Pattern 3	1.1	1.6	5.9	-1.3	-2.4	-0.6	0.5	1.9	-1.0	0.5	-0.4
Number of live births	1.0	1.5	2.1	1.5	1.2	1.4	-1.3	0.6	-0.9	-1.2	1.4
Forced expiratory volume in 1-second (FEV1)	2.5	8.5	14.2	-2.6	-1.8	-3.0	3.3	-1.5	3.2	3.8	-3.4
Pulse rate	1.0	1.7	4.0	-1.7	-2.0	-2.0	1.2	0.1	-0.3	0.7	-0.8
Happiness	0.2	0.2	1.0	0.2	-0.1	-0.1	-0.4	-1.0	-0.4	-0.3	0.1
Noisy workplace	0.7	0.9	2.0	0.8	0.7	0.3	1.0	-0.9	1.4	1.2	-0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.8	0.4	0.9	0.4	-0.4	-0.3	-0.0	-0.3	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	1.4	-1.1	-1.1	-1.2	0.8	0.1	-0.3	0.6	-0.6
Mouth/teeth dental problems: Dentures	2.0	3.4	6.2	1.5	1.1	1.6	-2.2	1.1	-2.0	-2.5	2.1
Asthma	1.8	3.6	5.6	1.8	1.8	2.0	-2.3	0.2	-1.6	-2.4	2.2
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	6.3	-2.0	-2.5	-2.4	1.3	-0.1	-0.4	1.5	-1.1
Medication: Cholesterol lowering	6.9	10.8	16.5	2.9	3.0	3.2	-4.0	-0.5	-3.2	-4.1	4.0
Depression (self-reported)	1.4	1.7	3.9	0.9	1.1	0.9	-1.6	-0.4	-1.6	-1.4	2.0
Medication: Lansoprazole	0.2	0.2	0.4	0.4	0.0	0.1	-0.6	-0.4	-0.6	-0.5	0.5
Prospective memory result	0.3	0.3	1.5	0.4	-0.2	0.4	0.3	1.2	0.3	0.5	-0.4
Lung cancer (father)	1.8	2.1	3.3	-1.3	-1.8	-1.5	1.6	1.4	0.8	1.4	-1.6
Illnesses of mother	5.0	6.2	9.2	-3.0	-3.0	-2.9	2.6	-0.3	1.1	3.0	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	9.0	16.6	-2.1	-1.8	-2.5	3.6	-2.1	3.4	4.1	-3.5
Pulse wave Arterial Stiffness index	2.0	2.3	4.4	-2.0	-1.4	-2.1	1.6	-0.3	0.9	1.5	-1.5
Impedance of arm (left)	0.3	1.2	3.6	0.3	0.1	0.3	1.3	-1.1	1.9	0.9	-1.6
Arm fat mass (right)	1.6	6.6	16.4	-4.0	-3.7	-3.9	1.1	1.1	-1.3	1.6	-0.9
Trunk predicted mass	0.5	2.6	6.4	-2.5	-2.3	-2.5	0.8	0.5	-0.5	1.3	-0.8
Standing height	0.8	7.8	12.2	-2.6	-2.3	-2.8	3.2	-1.4	2.6	3.5	-3.3
Length of working week for main job	0.1	0.2	0.4	-0.2	-0.7	-0.3	0.0	0.7	-0.5	-0.2	-0.1
Exposure to tobacco smoke at home	0.4	0.4	1.8	-0.2	0.0	0.0	-0.5	-1.4	-0.8	-0.5	0.6
Breastfed as a baby	0.2	0.2	0.9	0.0	0.2	0.3	-0.4	1.0	-0.4	-0.2	0.7
Tense / ‘highly strung’	0.2	0.4	1.2	0.1	0.2	0.3	-0.7	0.1	-1.1	-0.8	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	5.1	0.3	0.8	0.5	0.5	-2.3	0.9	0.4	-0.2
Hair/balding pattern: Pattern 4	1.5	3.7	10.8	1.4	1.7	1.3	1.7	-2.3	3.3	1.3	-1.6
Birth weight of first child	0.2	0.4	1.0	-1.0	-0.8	-0.9	0.1	0.2	-0.6	0.3	0.1
Peak expiratory flow (PEF)	1.7	4.0	7.7	-1.5	-0.6	-2.0	1.9	-2.8	2.1	2.5	-1.9
Pulse wave reflection index	1.5	1.8	3.1	1.5	1.3	1.8	-1.5	0.5	-0.9	-1.4	1.6
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.6	-0.3	-0.2	-0.2	-0.9	0.3	-1.6	-0.9	1.0
Loud music exposure frequency	1.6	1.8	4.1	0.3	0.5	0.2	-1.7	-1.2	-2.0	-1.6	1.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.4	0.3	1.2	0.6	-1.0	-0.8	-0.4	-0.6	1.0
Mouth/teeth dental problems: Bleeding gums	3.7	4.8	8.6	-1.6	-1.5	-1.6	2.8	-0.0	2.6	2.8	-2.9
Blood clot in the leg (DVT)	3.3	4.2	6.5	1.9	1.7	1.9	-2.5	-0.7	-2.1	-2.5	2.4
Medication: Paracetamol	2.5	4.2	5.6	-1.8	-1.6	-2.0	2.4	-1.8	2.0	2.3	-2.3
Headache pain in last month	1.3	2.3	3.5	-1.9	-1.6	-1.6	1.7	-0.1	1.0	1.9	-1.6
Medication for cholesterol, blood pressure or diabetes	6.0	9.9	16.6	-2.9	-2.6	-2.9	3.8	0.0	3.2	4.1	-3.8
Glaucoma (self-reported)	0.7	0.8	2.0	-0.7	-1.4	-0.8	0.9	0.7	0.2	1.0	-0.9
Gout (self-reported)	4.7	6.5	11.5	1.5	1.4	1.5	-3.4	1.3	-3.3	-3.4	3.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.7	1.1	1.0	1.3	0.0	0.2	0.8	-0.3	-0.1
Medication: Amlodipine	0.6	0.8	2.0	1.4	1.0	1.1	-0.2	-1.2	0.4	-0.4	0.4
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.9	1.4	1.4	1.2	-0.5	-1.1	0.5	-0.5	0.5
Birth weight	0.3	0.6	1.4	0.8	1.2	1.2	-0.4	0.5	-0.1	-0.6	0.7
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.5	-0.4	-1.3	-0.8	-0.7	1.6	-1.5	-0.8	0.5
High blood pressure (siblings)	2.0	2.8	5.2	2.1	2.3	1.8	-1.8	-0.7	-0.6	-1.6	1.8
Forced vital capacity (FVC), Best measure	3.4	12.5	21.2	-2.5	-2.1	-2.6	4.3	-2.0	4.3	4.6	-4.4
Body fat percentage	2.2	8.6	19.9	-4.5	-3.9	-4.4	2.1	0.9	-0.4	2.5	-1.8
Leg fat percentage (right)	1.3	4.5	12.0	-3.5	-2.8	-3.4	0.9	0.9	-1.2	1.3	-0.5
Arm fat-free mass (right)	1.1	5.5	12.7	-3.6	-3.1	-3.5	1.5	0.4	-0.4	2.1	-1.4
Exposure to tobacco smoke outside home	1.2	1.6	2.1	1.4	1.1	1.2	-1.4	-1.3	-1.0	-1.2	1.4
Comparative body size at age 10	3.5	9.7	25.2	-0.0	0.3	0.4	-4.0	1.4	-5.0	-4.1	4.2
Number of full brothers	1.7	2.1	4.5	0.6	0.7	1.4	-1.8	2.1	-1.4	-1.8	1.2
Worry too long after embarrassment	1.3	2.2	4.2	0.6	1.1	1.0	-2.0	0.6	-1.7	-2.1	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	4.4	1.3	1.6	1.4	0.0	-2.1	1.1	-0.1	-0.1
Wheeze or whistling in the chest in last year	1.4	2.5	4.1	1.5	1.2	1.9	-2.0	1.0	-1.2	-1.7	1.8
Number of children fathered	1.0	1.2	3.5	-0.0	0.4	-0.7	1.2	-0.9	1.9	1.3	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.8	1.6	-0.8	-0.1	-1.2	0.8	-1.2	0.9	0.7	-0.8
Age at first live birth	0.0	0.1	0.5	-0.1	0.7	-0.1	-0.1	-0.1	0.1	-0.3	0.1
Pulse wave peak to peak time	1.6	1.9	3.7	1.9	1.3	1.9	-1.5	0.2	-0.8	-1.3	1.3
Health satisfaction	0.1	0.1	0.6	-0.0	-0.1	-0.6	-0.1	-0.2	-0.7	-0.2	0.3
Shortness of breath walking on level ground	0.1	0.2	0.4	-0.2	0.6	0.1	-0.3	0.5	-0.5	-0.2	0.6
Qualifications: College or University degree	0.0	0.1	0.2	-0.3	-0.5	-0.5	0.3	0.3	0.0	0.3	-0.3
Eye problems/disorders: None of the above	0.0	0.0	0.1	0.4	0.2	0.3	-0.3	0.1	0.1	-0.0	0.1
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.6	-0.8	-0.5	-0.7	1.0	-1.2	1.1	0.7	-1.3
Emphysema/chronic bronchitis	4.4	4.9	8.1	1.6	1.0	1.5	-2.8	1.4	-2.9	-2.8	2.8
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	0.6	0.5	0.5	-0.4	0.1	-0.1	-0.3	0.4
Neck or shoulder pain in last month	1.2	1.7	4.6	-1.7	-2.1	-1.8	0.8	0.1	-0.5	1.1	-0.9
Medication: Blood pressure	4.6	8.1	12.8	2.8	2.5	2.7	-3.3	-0.1	-2.7	-3.6	3.4
Angina (self-reported)	2.7	3.6	6.9	2.5	2.4	2.6	-1.4	-1.7	-0.1	-1.6	1.5
Migraine (self-reported)	0.4	0.5	1.3	1.0	1.1	1.0	-0.1	-0.8	0.1	-0.3	0.3
Medication: Ibuprofen	1.9	2.3	5.0	-1.9	-2.2	-2.0	1.4	-0.6	-0.1	1.5	-1.2
Medication: Allopurinol	4.4	5.9	9.8	1.7	1.6	1.6	-3.1	0.8	-3.0	-3.0	3.1
Medication: Omeprazole	0.4	0.4	1.8	-0.5	-0.1	-0.5	0.6	1.3	0.6	0.3	-0.6
Medication: Seretide 50 evohaler	0.5	0.6	0.9	0.6	0.3	0.8	-0.9	0.7	-0.8	-1.0	0.7
Mean time to correctly identify matches	0.3	0.6	2.9	-0.7	-1.7	-0.6	0.4	-0.6	-0.3	0.4	-0.5
Heart disease (mother)	3.3	4.0	9.8	2.9	3.1	2.9	-0.6	-0.9	1.6	-1.1	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	6.4	-1.1	-1.2	-0.8	-1.1	2.2	-2.5	-0.9	1.1
Whole body fat mass	2.2	9.3	21.3	-4.6	-4.2	-4.6	2.0	0.8	-0.5	2.5	-1.8
Leg fat mass (right)	1.7	6.7	17.1	-4.1	-3.6	-4.0	1.2	0.9	-1.2	1.7	-0.9
Arm predicted mass (right)	1.4	6.9	15.3	-3.9	-3.4	-3.8	2.0	-0.0	0.1	2.5	-1.9
Pulse rate, automated reading	0.4	1.2	3.0	-1.3	-1.7	-1.3	-0.2	0.4	-1.6	-0.1	0.5
Alcohol intake frequency.	1.2	2.8	4.6	1.3	1.2	1.7	-2.1	-0.2	-1.9	-2.0	2.1
Comparative height size at age 10	0.7	3.8	9.4	-2.5	-3.1	-2.6	1.6	-0.2	0.1	1.6	-1.7
Number of full sisters	0.0	0.1	0.2	-0.2	-0.3	0.1	-0.2	0.3	-0.4	0.2	0.2
Suffer from ‘nerves’	1.7	2.6	4.2	1.2	1.6	1.8	-2.0	0.8	-1.2	-2.0	1.9
Overall health rating	0.7	1.4	3.5	0.7	0.3	0.6	-1.4	-0.4	-1.9	-1.7	1.5
Chest pain or discomfort	0.1	0.2	0.5	0.3	0.2	0.7	0.2	-0.5	0.5	0.3	-0.1
Had major operations	0.5	0.6	1.9	0.3	0.0	0.2	0.9	-0.7	1.4	0.7	-1.0
Age at last live birth	0.2	0.3	0.9	0.7	0.9	0.4	-0.3	0.1	0.1	-0.7	0.1
Family relationship satisfaction	0.3	0.3	1.6	-0.1	-0.5	-0.0	-0.5	-0.3	-1.3	-0.6	0.5
Leg pain on walking	0.3	0.4	2.3	-0.3	0.1	-0.2	-0.4	1.5	-0.4	-0.5	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.7	-0.1	0.6	0.0	-1.3	-0.4	-1.2	-0.9	1.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.0	0.6	-0.2	0.5	-0.7	0.2	-1.0	-0.3	0.7
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.9	-0.1	-0.5	0.0	-1.0	2.0	-1.9	-1.1	1.2
Medication: Aspirin	4.4	5.9	11.3	3.1	3.4	3.1	-2.2	-2.0	-0.1	-1.9	2.0
Supplements: Vitamin C	0.9	1.1	2.0	-0.4	-0.3	-0.7	1.1	-1.0	1.4	1.2	-1.3
Knee pain experienced in last month	0.2	0.3	0.8	-0.7	-0.7	-0.6	-0.0	-0.1	-0.9	-0.4	0.3
Hypertension (Self-reported)	7.2	20.0	28.9	5.4	5.3	5.1	-4.7	-0.2	-2.5	-5.0	4.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.5	0.0	0.5	0.0	0.6	-0.5	1.2	0.2	-0.7
Illnesses of father: Heart disease	5.6	7.7	17.5	3.9	4.2	3.7	-2.0	-1.2	-0.1	-2.2	2.3
Illnesses of siblings: Diabetes	5.9	7.3	10.4	3.2	2.6	2.5	-3.1	-0.1	-2.2	-3.2	3.1
Smoking status: Previous	0.0	0.1	0.3	0.5	-0.0	0.1	0.1	0.2	-0.2	-0.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.2	-0.8	-0.4	-0.8	0.9	-1.1	0.9	1.5	-0.9
Whole body fat-free mass	0.7	4.0	9.7	-3.1	-2.9	-3.0	1.0	0.7	-0.6	1.6	-1.0
Leg fat-free mass (right)	0.8	4.4	10.5	-3.2	-3.1	-3.0	0.9	1.0	-0.8	1.5	-0.9
Arm fat percentage (left)	1.4	5.7	13.9	-3.7	-3.4	-3.6	0.9	1.3	-1.4	1.3	-0.7
Average weekly red wine intake	2.7	3.9	7.4	-0.9	-1.0	-1.1	2.7	-1.7	2.6	2.2	-2.5
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.6	1.5	1.6	1.5	-0.8	0.0	0.1	-1.0	0.8
Mood swings	0.6	1.0	4.5	-0.6	-0.4	-0.1	-0.6	2.1	-1.4	-0.6	0.8
Loneliness, isolation	0.2	0.3	0.7	-0.6	-0.7	-0.8	0.5	-0.5	-0.0	0.3	-0.4
Long-standing illness, disability or infirmity	9.1	13.9	20.5	3.7	3.4	4.0	-4.5	0.0	-3.1	-4.5	4.5
Ever had bowel cancer screening	0.5	0.6	2.3	0.9	0.7	0.6	0.1	-1.5	0.1	-0.8	0.2
Diabetes diagnosed by doctor	7.9	13.0	18.8	4.2	3.8	3.5	-4.0	-1.7	-2.6	-4.3	4.0
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	5.1	-0.8	-1.2	-0.8	2.3	-0.0	1.9	2.1	-2.2
Friendships satisfaction	0.3	0.4	1.6	0.4	0.6	0.1	0.4	-1.2	0.9	0.4	-0.3
Qualifications: nursing, teaching	0.6	0.9	1.7	0.4	0.5	0.4	-1.2	0.9	-1.2	-1.2	1.3
Commuting to job workplace: Walk	0.3	0.3	1.0	0.3	0.9	0.2	0.3	-0.6	1.0	0.2	-0.1
Eye problems/disorders: Cataract	0.3	0.4	2.0	-0.4	0.3	-0.6	0.5	-1.4	0.5	0.2	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.9	0.6	0.5	0.7	-0.8	-0.2	-0.3	-0.9	0.5
Medication for cholesterol	6.7	10.1	14.5	-3.8	-3.6	-3.4	3.5	-0.4	1.9	3.7	-3.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.8	-0.8	-1.2	-1.1	0.8	-1.3	-0.2	0.4	-0.5
Back pain experienced in last month	0.2	0.3	0.7	0.4	0.7	0.6	-0.9	-0.0	-0.2	-0.8	0.5
Mineral and other dietary supplements	0.1	0.2	0.6	-0.5	-0.0	-0.2	-0.8	0.1	-0.5	-0.4	0.5
Breast cancer (self-reported)	1.2	1.4	4.1	1.2	1.6	1.0	0.7	-0.7	2.0	0.7	-0.9
Asthma (self-reported)	1.4	2.7	4.0	1.7	1.6	1.9	-2.0	-0.3	-1.2	-1.9	1.9
Osteoporosis (self-reported)	0.6	0.7	1.2	0.9	0.5	0.9	-1.0	0.8	-0.8	-1.1	0.8
Osteoarthritis (self-reported)	1.3	1.7	6.2	-0.2	-0.4	-0.3	-1.5	0.8	-2.5	-1.0	1.9
Medication: Aspirin	4.9	6.3	12.2	3.2	3.5	3.2	-2.0	-2.6	0.1	-1.8	2.0
Medication: Gliclazide	10.4	11.8	17.7	3.8	3.1	3.8	-4.1	0.2	-2.7	-4.2	3.8
Illnesses of father: None of the above (group 1)	1.4	1.8	4.2	-1.8	-2.1	-1.7	0.5	1.6	-0.9	0.4	-0.2
Smoking status: Current	0.9	1.4	3.8	-1.9	-1.9	-1.5	0.1	0.9	-0.9	0.5	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.2	9.0	15.1	-2.4	-2.6	-3.0	3.6	-1.6	2.8	3.9	-3.4
Whole body water mass	0.7	4.1	9.9	-3.1	-2.9	-3.0	1.1	0.6	-0.5	1.6	-1.1
Leg predicted mass (right)	0.8	4.2	10.1	-3.2	-3.1	-3.0	0.9	1.0	-0.8	1.4	-0.9
Arm fat mass (left)	1.8	7.2	17.3	-4.2	-3.9	-4.1	1.2	1.2	-1.3	1.7	-1.0
Number of self-reported non-cancer illnesses	5.2	9.0	12.9	3.0	3.0	3.1	-3.5	-0.6	-2.4	-3.6	3.6
Average weekly champagne plus white wine intake	0.7	0.9	2.0	-1.3	-1.0	-1.4	0.7	1.0	-0.3	0.9	-0.3
Miserableness	0.3	0.5	1.4	-0.1	-0.1	0.4	-0.6	-0.7	-1.2	-0.6	0.9
Guilty feelings	0.3	0.4	1.3	-0.9	-1.1	-0.7	0.0	0.0	-0.6	0.5	0.0
Wears glasses or contact lenses	0.9	1.1	2.0	1.2	1.4	1.0	-0.7	1.3	-0.2	-1.0	0.8
Ever taken oral contraceptive pill	0.4	0.5	1.2	1.1	1.1	0.6	-0.6	-0.0	0.1	-0.9	0.4
Hearing aid user	1.9	2.2	7.4	1.7	1.2	1.2	-1.0	-2.7	-0.8	-1.3	1.1
Mother’s age at death	0.3	0.4	0.7	-0.7	-0.7	-0.8	0.7	-0.7	0.0	0.7	-0.4
Financial situation satisfaction	0.7	0.9	2.3	-1.3	-1.3	-1.5	0.5	0.4	-0.4	0.8	-0.5
Tinnitus: Yes, now most or all of the time	1.8	2.1	5.9	0.6	0.1	0.3	-1.9	0.3	-2.4	-1.7	1.9
Commuting to job workplace: Public transport	0.5	0.6	1.0	0.6	0.8	0.7	-1.0	0.1	-0.6	-0.9	1.0
Eye problems/disorders: Glaucoma	3.8	4.5	9.5	-2.5	-3.1	-2.5	2.1	0.9	0.3	2.1	-2.0
Medication: Blood pressure	10.7	20.3	27.4	5.2	4.9	5.0	-5.1	-0.2	-2.8	-5.2	5.0
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.7	1.0	1.4	1.0	-0.9	1.6	-0.3	-0.9	1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.3	0.8	0.3	0.6	1.1	0.0	1.1	0.6	-0.9
High cholesterol (Self-reported)	3.7	6.5	10.2	2.4	2.2	2.3	-3.2	-0.8	-2.5	-3.1	3.0
Medication: Bendroflumethiazide	2.7	4.0	6.7	1.6	1.5	1.8	-2.4	-0.2	-2.2	-2.6	2.6
Medication: Paracetamol	2.1	3.3	4.6	-1.3	-1.3	-1.5	2.1	-2.1	1.8	2.1	-2.0
Medication: Lisinopril	1.4	1.8	3.0	1.1	1.0	0.9	-1.6	1.1	-1.5	-1.7	1.7
Medication: Atorvastatin	2.4	3.0	5.3	1.2	1.0	1.0	-2.2	-0.8	-2.3	-2.3	2.1
Illnesses of father: High blood pressure	2.2	2.8	4.5	1.8	2.1	1.9	-1.6	-1.3	-0.8	-1.7	1.6
Alcohol drinker status: Never	0.3	0.4	1.2	0.0	-0.2	-0.0	-0.9	-0.3	-1.1	-0.8	0.7
Ever smoked	0.7	1.3	2.9	-1.0	-1.7	-1.4	1.0	1.3	0.0	0.7	-1.1
Basal metabolic rate	0.9	5.2	12.7	-3.6	-3.2	-3.4	1.1	0.7	-0.8	1.7	-1.1
Leg fat percentage (left)	1.1	4.1	10.9	-3.3	-2.5	-3.3	1.0	0.9	-0.9	1.4	-0.7
Arm fat-free mass (left)	1.0	5.1	11.8	-3.4	-3.0	-3.4	1.4	0.5	-0.3	2.0	-1.4
Number of operations (self-reported)	1.7	2.6	7.7	-0.2	-0.2	-0.5	2.1	-0.1	2.8	1.7	-2.3
Average weekly beer plus cider intake	0.1	0.1	0.4	-0.0	-0.4	0.1	-0.1	-0.7	-0.0	0.1	-0.2
Irritability	0.7	1.2	4.1	-0.1	0.2	0.5	-1.2	-0.1	-2.0	-1.2	1.5
Risk taking	0.3	0.5	1.6	0.5	1.0	0.8	0.3	-0.2	1.3	0.6	-0.3
Ever had prostate specific antigen (PSA) test	1.8	2.0	4.0	-0.7	-0.9	-1.0	1.9	-0.6	1.8	1.7	-2.0
Fractured/broken bones in last 5 years	2.1	2.7	4.3	1.7	1.6	1.5	-1.8	1.1	-1.2	-2.1	1.8
Age started oral contraceptive pill	1.6	2.0	4.0	-0.6	-0.7	-0.5	2.0	-1.1	2.0	1.5	-2.0
Diastolic blood pressure, automated reading	3.4	10.5	15.3	3.9	3.5	3.8	-3.6	-0.1	-2.1	-3.4	3.6
Ever depressed for a whole week	1.0	1.2	2.1	0.8	1.3	0.8	-1.3	-0.5	-0.9	-1.4	1.5
Unable to work because of sickness or disability	1.1	1.5	2.5	1.3	1.1	1.6	-1.3	-0.5	-0.8	-1.4	1.3
Commuting to job workplace: Cycle	1.1	1.3	3.3	1.3	1.6	1.8	-0.9	0.6	0.0	-1.1	0.8
Myopia	2.6	3.8	5.5	1.7	2.3	2.3	-1.9	2.2	-1.0	-2.0	1.9
Vascular/heart problems diagnosed by doctor	11.6	31.5	43.2	-6.6	-6.4	-6.5	6.0	0.1	3.3	6.3	-6.2
Cholesterol lowering medication	6.9	10.2	15.3	3.9	3.8	3.7	-3.3	-1.0	-1.6	-3.6	3.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.5	-1.0	-0.5	-0.9	0.7	1.6	0.6	0.4	-1.0
Pain experienced in last month	0.4	0.6	2.4	1.5	0.9	1.2	-0.2	0.0	0.8	-0.0	0.0
Supplements: Calcium	0.2	0.2	0.7	-0.2	-0.5	-0.2	-0.3	0.4	-0.8	-0.8	0.3
Basal cell carcinoma (self-reported)	0.4	0.5	2.0	1.0	1.4	0.5	-0.1	-0.0	0.7	-0.3	0.1
Heart attack/myocardial infarction (self-reported)	5.3	6.8	13.5	3.7	3.6	3.5	-1.9	-2.1	0.5	-2.2	1.7
Deep venous thrombosis (DVT) (self-reported)	3.3	4.3	6.6	1.9	1.7	2.0	-2.5	-0.8	-2.1	-2.6	2.5
Heart disease (siblings)	1.1	1.4	3.3	1.8	1.6	1.5	-0.8	-0.7	0.6	-1.0	0.4
Alcohol drinker status: Previous	0.5	0.6	2.0	-0.2	-0.4	-0.5	-0.6	-1.1	-1.4	-0.5	0.8
Pack years of smoking	0.3	0.5	1.8	0.6	0.8	0.5	-0.6	-1.3	-0.2	-0.4	0.6
Impedance of whole body	0.5	2.5	7.0	0.0	0.1	-0.0	2.0	-1.4	2.6	1.7	-2.2
Leg fat mass (left)	1.7	6.7	16.6	-4.1	-3.5	-4.0	1.3	1.0	-1.2	1.8	-1.0
Arm predicted mass (left)	1.0	5.2	11.8	-3.4	-3.1	-3.4	1.6	0.5	-0.1	2.1	-1.5