TWAS hub - DBR1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Frontal Cortex BA9	0.181	0.0776	0.0029	0.104	NA	0.098	NA	0.106	0.0011	NA	0.0014	NA	0.00097
2	TCGA	Liver Hepatocellular Carcinoma	0.053	0.0320	0.0021	0.009	0.037	-0.001	NA	0.014	0.1100	0.0073	0.3700	NA	0.07200

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Coronary Artery Disease (CAD)	13.6	16.3	28.6	5.3	2.0
Illnesses of father: Heart disease	9.3	12.9	14.8	3.9	3.3
Vascular/heart problems diagnosed by doctor	9.3	25.5	45.3	-6.7	-2.4
Medication: Blood pressure	9.0	17.1	29.5	5.4	2.2
Waist Hip Ratio (WHR)	8.9	39.9	64.8	8.1	3.9
Medication: Gliclazide	7.6	8.5	16.9	4.1	-0.4
Cardiovascular Disease	7.0	23.1	39.6	6.3	2.6
Type 2 Diabetes (T2D) (2018)	6.9	13.0	25.6	5.1	0.6
Medication for cholesterol	6.8	10.3	15.1	-3.9	-2.4
Medication: Ramipril	6.7	8.6	15.3	3.9	1.3
High blood pressure (mother)	6.4	9.0	15.4	3.9	1.6
Medication: Metformin	6.3	8.9	17.6	4.2	-0.6
High blood pressure	6.2	17.4	32.7	5.7	1.4
Heart attack	6.0	7.7	12.8	3.6	1.6
Medication: Cholesterol lowering	6.0	9.3	14.2	3.8	2.1
Long-standing illness, disability or infirmity	5.9	9.0	16.8	4.1	1.1
Diabetes diagnosed by doctor	5.9	9.7	18.7	4.3	0.8
Hypertension (Self-reported)	5.8	16.2	28.9	5.4	1.9
Illnesses of siblings: Diabetes	5.8	7.2	13.1	3.6	1.1
Heart attack/myocardial infarction (self-reported)	5.6	7.2	11.9	3.4	1.6
Medication: Simvastatin	5.5	8.0	14.5	3.8	1.2
Cholesterol lowering medication	5.4	7.9	15.8	4.0	0.1
Medication: Aspirin	4.7	6.1	10.7	3.3	1.2
Taking other prescription medications	4.6	7.1	13.2	3.6	1.0
Systolic Blood Pressure	4.5	22.6	40.6	6.4	2.1
Number of treatments/medications taken	4.4	7.8	13.1	3.6	1.6
Diabetes (self-reported)	4.4	6.7	13.4	3.7	-0.4
Illnesses of mother	4.4	5.5	8.7	-2.9	-1.5
Angina (self-reported)	4.3	5.7	6.6	2.6	2.2
Medication: Aspirin	4.3	5.6	9.9	3.1	1.1
Number of incorrect matches in round	4.1	6.7	13.2	-3.6	0.5
Serious illness, injury or assault to yourself	3.9	4.8	5.9	1.9	2.4
Number of self-reported non-cancer illnesses	3.9	6.8	11.1	3.3	1.6
Heart disease (mother)	3.7	4.5	6.7	2.6	1.5
Medication: Atenolol	3.6	4.5	8.2	2.9	0.9
Medication for cholesterol, blood pressure or diabetes	3.5	5.7	10.9	-3.3	-0.7
Angina	3.4	4.4	5.0	2.2	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.4	4.1	7.8	-0.6	-2.8
Illness, injury, bereavement, stress in last 2 years	3.2	3.9	7.7	0.2	-2.8
Intelligence (Savage-Jansen 2018)	3.0	9.2	10.2	3.2	2.9
High cholesterol (Self-reported)	3.0	5.3	8.4	2.9	1.5
Systolic blood pressure, automated reading	2.9	8.6	16.4	4.1	0.8
Trunk fat percentage	2.9	11.4	19.9	-4.5	-1.7
Financial difficulties in last 2 years	2.9	3.8	5.4	1.5	2.3
Eye problems/disorders: Glaucoma	2.9	3.5	6.9	-2.6	0.1
Diastolic blood pressure, automated reading	2.9	9.1	16.8	4.1	1.2
Wears glasses or contact lenses	2.8	3.2	4.7	1.3	2.2
Illnesses of father: High blood pressure	2.8	3.5	4.1	2.0	1.7
Illnesses of siblings	2.7	3.7	7.4	-2.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.6	6.4	-2.5	2.2
Medication: Blood pressure	2.6	4.6	9.2	3.0	-0.0
Trunk fat mass	2.5	10.8	20.3	-4.5	-1.1
Alcohol usually taken with meals	2.5	4.0	8.0	-2.8	0.1
Body fat percentage	2.5	9.7	17.4	-4.2	-1.4
Time employed in main current job	2.4	2.8	3.2	-1.6	-1.8
Medication: Lansoprazole	2.4	2.7	5.3	0.3	-2.3
Age at First Birth	2.3	3.3	3.8	-1.9	-1.7
Father’s age at death	2.3	3.1	6.2	-2.5	0.3
Depression (self-reported)	2.3	2.8	3.9	1.3	2.0
Pulse wave Arterial Stiffness index	2.3	2.7	4.3	-2.1	-1.0
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	4.3	0.9	2.1
Pulse wave peak to peak time	2.2	2.6	3.7	1.9	1.2
Whole body fat mass	2.2	9.2	18.0	-4.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.4	3.4	-1.2	1.9
Breast cancer (self-reported)	2.2	2.6	4.7	0.7	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	4.2	1.1	2.0
Leg pain on walking	2.1	2.7	5.3	-0.3	-2.3
Illnesses of father: None of the above (group 1)	2.1	2.6	2.8	-1.5	-1.7
Primary Biliary Cirrhosis	2.0	2.8	5.3	2.3	0.6
Lung FVC	2.0	10.0	18.2	-4.3	1.3
Ever used hormone-replacement therapy (HRT)	2.0	2.5	4.9	0.4	2.2
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	3.5	1.1	1.9
Hair/balding pattern: Pattern 3	2.0	3.0	3.9	-1.5	-2.0
Lung cancer (father)	2.0	2.3	2.9	-1.7	-1.3
Medication: Allopurinol	2.0	2.7	5.2	2.3	-0.4
Chronic bronchitis/emphysema (father)	1.9	2.2	4.4	-2.1	0.1
Hip circumference	1.9	8.2	15.9	-4.0	-0.7
Financial situation satisfaction	1.9	2.3	2.6	-1.4	-1.6
Ever had prostate specific antigen (PSA) test	1.9	2.1	2.7	-1.3	1.6
Diabetes (mother)	1.8	2.3	3.4	1.9	-1.1
Gout (self-reported)	1.8	2.4	4.8	2.2	-0.3
Unable to work because of sickness or disability	1.8	2.3	2.4	1.5	1.6
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	4.1	2.0	0.6
Length of working week for main job	1.7	1.9	3.8	-0.2	-1.9
Leg fat mass (right)	1.7	6.5	13.0	-3.6	-0.3
Bipolar Disorder (2011)	1.6	1.5	2.3	0.8	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	3.6	-1.9	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	5.0	-2.2	2.2
Blood clot in the leg (DVT)	1.6	2.1	4.0	2.0	0.5
Emphysema/chronic bronchitis	1.6	1.8	3.7	1.9	0.1
Neck or shoulder pain in last month	1.6	2.2	3.1	-1.8	-1.1
Arm fat mass (left)	1.6	6.4	12.8	-3.6	-0.2
Leg fat mass (left)	1.6	6.4	12.7	-3.6	-0.4
Crohns Disease (2012)	1.5	2.4	3.0	-1.4	1.7
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.0	1.7	0.6
Medication for hormone replacement therapy	1.5	1.7	3.2	-0.4	1.8
Qualifications: CSEs or equivalent	1.5	2.0	4.0	-0.3	-2.0
Forced vital capacity (FVC)	1.5	5.8	10.8	-3.3	0.9
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	3.4	-1.9	0.6
Medication: Paracetamol	1.5	2.6	4.7	-2.2	-0.6
High blood pressure (siblings)	1.5	2.2	4.3	2.1	0.4
Forced vital capacity (FVC), Best measure	1.5	5.4	8.7	-2.9	1.5
Suffer from ‘nerves’	1.5	2.3	3.7	1.9	1.0
Hearing aid user	1.5	1.7	2.2	1.5	1.1
Major Depression (MDD)	1.4	1.6	2.3	-1.5	1.0
Average weekly spirits intake	1.4	1.7	2.8	-0.8	-1.7
Falls in the last year	1.4	1.9	3.8	1.9	0.2
Arm fat mass (right)	1.4	5.9	11.8	-3.4	-0.0
Headache pain in last month	1.4	2.4	4.2	-2.0	-0.8
Arm fat percentage (left)	1.4	5.5	10.1	-3.2	-1.0
Age when periods started (menarche)	1.3	3.2	3.3	-1.8	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	5.8	-2.4	-0.4
Weight	1.3	6.4	12.8	-3.6	0.3
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	6.9	-2.6	1.4
Mouth/teeth dental problems: Dentures	1.3	2.2	3.2	1.8	-1.1
Leg fat percentage (right)	1.3	4.8	9.3	-3.0	-0.6
Medication: Ibuprofen	1.3	1.6	3.1	-1.8	0.3
Average weekly red wine intake	1.3	1.9	2.6	-1.6	-1.1
Osteoporosis (self-reported)	1.3	1.6	2.7	0.7	-1.6
Medication: Bendroflumethiazide	1.3	1.9	3.7	1.9	-0.2
Medication: Atorvastatin	1.3	1.6	2.3	1.5	0.9
Fractured/broken bones in last 5 years	1.3	1.7	3.3	1.8	0.2
Prostate Cancer	1.2	1.8	3.5	-0.1	1.9
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	4.0	-2.0	-1.1
Arm fat percentage (right)	1.2	4.7	9.3	-3.0	-0.5
Pulse rate	1.2	2.0	3.3	-1.8	-0.8
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	1.7	-1.0	1.3
Hair/balding pattern: Pattern 4	1.2	2.9	5.2	0.8	2.3
Pulse wave reflection index	1.2	1.5	2.7	1.6	0.6
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.3	-0.7	-1.5
Arm predicted mass (right)	1.2	6.2	11.7	-3.4	0.8
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.0	1.4	1.0
Leg fat percentage (left)	1.2	4.5	8.4	-2.9	-0.8
Ever depressed for a whole week	1.2	1.5	1.9	1.1	1.4
Myopia	1.2	1.8	3.5	1.9	0.4
Heart disease (siblings)	1.2	1.4	2.8	1.7	0.3
Chronotype (morning person)	1.1	2.5	4.0	-2.0	-1.0
Hand grip strength (right)	1.1	3.1	6.0	-2.5	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.0	-0.8	1.4
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.2	0.6	1.5
Medication: Paracetamol	1.1	1.7	3.1	-1.8	-0.6
Arm fat-free mass (left)	1.1	5.6	8.6	-2.9	1.6
Arm predicted mass (left)	1.1	5.6	8.7	-3.0	1.6
Verbal and Numeric Reasoning (VNR)	1.0	2.3	2.7	1.7	1.4
HbA1C	1.0	1.1	1.3	1.2	0.9
Schizophrenia (2014)	1.0	2.2	2.2	1.5	1.5
BMI	1.0	5.8	11.6	-3.4	-0.1
Lung FEV1/FVC ratio	1.0	5.1	5.2	2.2	2.3
Leg fat-free mass (left)	1.0	5.1	9.6	-3.1	0.8
Leg predicted mass (left)	1.0	5.2	9.7	-3.1	0.8
Number of live births	1.0	1.5	2.3	1.5	0.8
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	3.3	0.9	1.8
Arm fat-free mass (right)	1.0	5.2	9.2	-3.0	1.1
Alcohol intake frequency.	1.0	2.4	3.8	2.0	1.0
Smoking status: Current	1.0	1.6	2.0	-1.4	-1.1
Ever smoked	1.0	1.8	2.0	-1.4	-1.3
Schizophrenia (2018)	0.9	1.9	2.5	1.6	1.2
Heel T-Score	0.9	7.0	13.8	-3.7	-0.4
Hypothyroidism (self reported)	0.9	2.1	3.5	0.9	1.9
Sensitivity / hurt feelings	0.9	1.5	2.7	-1.6	-0.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.0	1.0	-1.0
Sitting height	0.9	6.3	9.7	-3.1	1.7
Nervous feelings	0.9	1.7	2.5	1.6	0.9
Fluid intelligence score	0.9	1.9	3.3	1.8	0.7
Asthma	0.9	1.8	3.5	1.9	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.7	0.2	1.6
Wheeze or whistling in the chest in last year	0.9	1.5	2.8	1.7	0.5
Pain experienced in last month	0.9	1.5	1.8	1.4	1.1
Bipolar Disorder or Schizophrenia	0.8	1.9	2.3	1.5	1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.9	1.4	-0.4
Medication: Levothyroxine sodium	0.8	1.4	2.2	0.8	1.5
Body mass index (BMI)	0.8	3.4	6.8	-2.6	-0.1
Mother’s age at death	0.8	1.0	1.2	-1.1	-0.8
Basal metabolic rate	0.8	4.7	8.4	-2.9	1.0
Age started oral contraceptive pill	0.8	0.9	1.4	-1.2	-0.7
Commuting to job workplace: Cycle	0.8	1.0	1.9	1.4	-0.0
Ulcerative Colitis	0.7	1.0	1.0	1.0	-1.0
Hearing difficulty/problems: Yes	0.7	1.0	1.3	0.8	-1.1
Medication: Co-codamol	0.7	0.8	1.1	1.0	0.8
Current tobacco smoking	0.7	1.1	1.3	-1.0	-1.1
Hair/balding pattern: Pattern 2	0.7	0.8	1.4	0.6	1.2
Noisy workplace	0.7	0.9	1.6	0.4	1.2
Number of full brothers	0.7	0.8	1.0	1.0	-0.8
Supplements: Vitamin C	0.7	0.9	1.1	-0.8	-1.0
Whole body fat-free mass	0.7	4.0	6.2	-2.5	1.4
Leg fat-free mass (right)	0.7	3.6	6.6	-2.6	0.8
Commuting to job workplace: Walk	0.7	0.7	1.4	0.2	1.2
Asthma (self-reported)	0.7	1.4	2.9	1.7	-0.0
Whole body water mass	0.7	4.2	6.4	-2.5	1.4
Leg predicted mass (right)	0.7	3.5	6.4	-2.5	0.8
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.1	1.1	0.8
Alcohol drinker status: Never	0.7	0.9	1.6	0.4	-1.3
Number of operations (self-reported)	0.7	1.1	1.1	-1.1	1.0
Supplements: Calcium	0.7	0.8	1.4	-0.3	-1.2
Alzheimer’s Disease (in father)	0.6	0.7	1.2	0.4	-1.1
Triglycerides	0.6	1.0	1.8	1.4	0.4
Height	0.6	10.8	21.2	-4.6	-0.7
Relative age of first facial hair	0.6	1.3	2.0	0.7	-1.4
Vitamin and mineral supplements	0.6	0.9	1.7	1.3	0.1
Multivitamins +/- minerals	0.6	0.8	1.5	-1.2	0.2
Hearing difficulty/problems with background noise	0.6	1.0	1.9	-0.2	-1.4
Had menopause	0.6	0.8	1.3	-1.1	0.5
Qualifications: None of the above	0.6	1.3	2.0	-0.7	-1.4
Trunk fat-free mass	0.6	3.3	3.9	-2.0	1.7
Impedance of arm (left)	0.6	2.8	5.4	-0.4	-2.3
Trunk predicted mass	0.6	3.5	3.8	-2.0	1.8
Medication: Amlodipine	0.6	0.8	1.1	1.0	0.7
Exposure to tobacco smoke outside home	0.6	0.8	1.4	1.2	0.4
Number of children fathered	0.6	0.6	1.2	-0.2	1.1
Comparative height size at age 10	0.6	3.4	6.8	-2.6	0.2
Chest pain or discomfort	0.6	0.9	1.7	0.1	1.3
Ever had bowel cancer screening	0.6	0.7	1.2	0.4	-1.1
Commuting to job workplace: Public transport	0.6	0.8	0.9	0.8	0.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.4	-1.2	0.3
Depression (Nagel 2018)	0.5	0.7	1.4	-0.2	1.2
Crohns Disease (2017)	0.5	1.1	1.6	-1.3	0.8
Fed-up feelings	0.5	0.9	1.6	0.4	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.2	-1.1	0.6
Peak expiratory flow (PEF)	0.5	1.2	2.3	-1.5	0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	0.8	0.9	0.8
Birth weight	0.5	1.0	1.1	1.0	1.1
Knee pain experienced in last month	0.5	0.8	1.4	-0.5	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.6	-0.7	1.3
Average weekly champagne plus white wine intake	0.5	0.7	1.2	-1.1	0.4
Medication: Lisinopril	0.5	0.6	1.2	1.1	-0.3
Basal cell carcinoma (self-reported)	0.5	0.6	0.9	0.5	-1.0
Impedance of whole body	0.5	2.6	4.5	-0.8	-2.1
Alzheimer’s Disease (in mother)	0.4	0.4	0.8	0.9	0.3
Blood Red Count	0.4	3.4	4.8	-1.5	-2.2
Allergy or Eczema	0.4	1.0	1.1	-1.0	-1.0
Respiratory disease	0.4	0.9	1.7	1.3	0.1
Hair Pigment	0.4	12.5	23.7	4.9	1.1
Hand grip strength (left)	0.4	1.1	2.1	-1.4	0.4
Pack years adult smoking proportion	0.4	0.6	0.9	1.0	-0.5
Maternal smoking around birth	0.4	0.5	0.6	0.7	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	0.6	-0.8	-0.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	-0.3	-0.9
Past tobacco smoking	0.4	0.7	1.0	0.7	1.0
Allergy	0.4	0.9	1.5	-1.2	-0.6
Pain all over the body in last month	0.4	0.4	0.6	0.3	-0.8
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.6	0.4	1.3
Standing height	0.4	4.4	8.2	-2.9	0.8
Glaucoma (self-reported)	0.4	0.5	0.9	-0.9	-0.4
Worry too long after embarrassment	0.4	0.6	1.2	1.1	0.1
Migraine (self-reported)	0.4	0.5	1.0	1.0	-0.3
Medication: Omeprazole	0.4	0.4	0.7	-0.8	0.4
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.5	0.7	0.6
Loneliness, isolation	0.4	0.5	0.6	-0.8	0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.8	0.6	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.9	-1.0	0.2
Osteoarthritis (self-reported)	0.4	0.6	0.9	0.4	1.0
Alcohol drinker status: Previous	0.4	0.4	0.8	0.3	0.9
Pack years of smoking	0.4	0.6	0.7	0.8	-0.8
Ulcerative Colitis (UC)	0.3	0.6	1.2	1.1	-0.0
Fasting Glucose	0.3	0.4	0.8	0.9	0.3
HDL Cholesterol	0.3	0.5	0.8	-0.4	0.9
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.8	-0.9	0.4
Townsend deprivation index at recruitment	0.3	0.4	0.7	-0.0	0.8
Average weekly fortified wine intake	0.3	0.4	0.7	-0.8	-0.3
Relative age voice broke	0.3	0.5	1.0	-0.0	-1.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	0.9	-1.0	0.0
Happiness	0.3	0.3	0.6	0.2	0.8
Prospective memory result	0.3	0.3	0.6	0.3	0.8
Loud music exposure frequency	0.3	0.4	0.7	0.8	0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	0.9	0.2
Medication: Seretide 50 evohaler	0.3	0.3	0.4	0.6	0.5
Age at last live birth	0.3	0.4	0.6	0.5	-0.8
Qualifications: nursing, teaching	0.3	0.5	0.5	0.7	0.7
Ever taken oral contraceptive pill	0.3	0.3	0.5	0.7	0.4
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.7	0.8	-0.4
Bipolar Disorder (2018)	0.2	0.2	0.3	0.5	0.5
Depressed Affect (Nagel 2018)	0.2	0.5	0.6	0.8	0.5
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	0.5	-0.7
LDL Cholesterol	0.2	0.4	0.5	0.7	0.5
Neuroticism (2016)	0.2	0.3	0.5	-0.2	0.7
Blood Eosinophil Count	0.2	1.6	2.5	-1.6	-0.8
Blood White Count	0.2	1.3	2.0	0.8	-1.4
Supplements: Zinc	0.2	0.3	0.3	0.5	-0.5
Diabetes (father)	0.2	0.2	0.5	-0.0	0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.1	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.9	-1.0	0.1
Stomach or abdominal pain in last month	0.2	0.2	0.4	-0.7	-0.2
Impedance of leg (left)	0.2	1.0	1.9	-0.1	-1.4
Waist circumference	0.2	0.7	1.1	0.5	1.1
Had other major operations	0.2	0.3	0.5	-0.2	0.7
Mouth/teeth dental problems	0.2	0.3	0.6	-0.3	0.8
Impedance of arm (right)	0.2	0.9	1.9	0.1	-1.4
Breastfed as a baby	0.2	0.3	0.3	0.5	0.5
Comparative body size at age 10	0.2	0.6	1.3	1.1	-0.1
Age at first live birth	0.2	0.3	0.6	0.1	-0.8
Health satisfaction	0.2	0.2	0.3	-0.3	0.5
Qualifications: College or University degree	0.2	0.6	0.9	-0.5	1.0
Overall health rating	0.2	0.5	0.5	0.7	0.7
Had major operations	0.2	0.3	0.6	0.0	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.5	-0.2	0.7
Eye problems/disorders: Cataract	0.2	0.2	0.3	-0.5	-0.3
Guilty feelings	0.2	0.3	0.4	-0.7	-0.5
Irritability	0.2	0.3	0.5	0.3	0.7
Risk taking	0.2	0.3	0.4	0.5	0.7
Neuroticism (Nagel 2018)	0.1	0.1	0.3	0.5	-0.0
Reaction Time	0.1	0.2	0.3	0.0	0.6
Ovarian Cancer	0.1	0.1	0.1	0.2	-0.4
Mean Putamen Volume	0.1	0.1	0.2	0.4	-0.2
Lupus	0.1	0.1	0.2	0.0	0.4
Rheumatoid Arthritis	0.1	0.1	0.2	-0.4	-0.3
Blood Platelet Count	0.1	1.0	1.7	-1.3	0.6
Smoking Status	0.1	0.1	0.2	-0.4	-0.2
Tanning	0.1	1.1	1.2	-1.0	1.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.0	-0.5
Impedance of leg (right)	0.1	0.5	1.0	-0.1	-1.0
Worrier / anxious feelings	0.1	0.3	0.5	0.2	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.1	0.6
Birth weight of first child	0.1	0.2	0.2	-0.5	-0.4
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.3	-0.1	-0.6
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.5	-0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	0.6	-0.2
Mean time to correctly identify matches	0.1	0.2	0.5	-0.7	0.0
Pulse rate, automated reading	0.1	0.4	0.7	-0.9	-0.3
Mood swings	0.1	0.1	0.2	-0.3	-0.5
Back pain experienced in last month	0.1	0.2	0.2	0.5	-0.5
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.0	-0.4
Schizophrenia vs Biploar Disorder	0.0	0.1	0.1	-0.3	0.2
Worry (Nagel 2018)	0.0	0.0	0.1	0.3	-0.1
Irritable Bowel Disease (IBD)	0.0	0.0	0.0	0.0	0.1
Breast Cancer	0.0	0.0	0.0	0.2	0.1
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	-0.1	-0.2
Neuroticism	0.0	0.0	0.1	-0.2	0.2
Severe depression (siblings)	0.0	0.0	0.1	-0.0	-0.3
Supplements: Glucosamine	0.0	0.1	0.1	-0.3	0.2
Neuroticism score	0.0	0.0	0.0	0.0	0.1
Alcohol intake versus 10 years previously	0.0	0.0	0.0	-0.1	0.1
Exposure to tobacco smoke at home	0.0	0.0	0.0	0.0	0.1
Tense / ‘highly strung’	0.0	0.1	0.1	0.3	-0.1
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	-0.2	0.0
Shortness of breath walking on level ground	0.0	0.1	0.1	0.1	-0.3
Number of full sisters	0.0	0.0	0.0	-0.1	-0.0
Family relationship satisfaction	0.0	0.0	0.0	-0.1	-0.1
Smoking status: Previous	0.0	0.0	0.0	0.2	-0.1
Friendships satisfaction	0.0	0.0	0.0	0.1	0.1
Mineral and other dietary supplements	0.0	0.0	0.0	0.0	0.0
Miserableness	0.0	0.1	0.1	0.4	0.0
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	0.0	0.2

Hub : Genes

DBR1

Models

Trait associations