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chr7:132,241,297-134,834,499

Best TWAS P=1.13e-07 · Best GWAS P=8.6e-08 conditioned to 0.38

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	The Cancer Genome Atlas	Colon Adenocarcinoma	AKR1B15	0.10	0.12	lasso	2	0.12	2.0e-07	-5.3	-5.3	1.1e-07	0.93	0.01	0.99	TRUE
1	GTEx	Adipose Subcutaneous	EXOC4	0.13	0.05	enet	15	0.04	5.8e-04	-4.0	5.2	1.6e-07	-0.13	0.43	0.14	TRUE
6	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AKR1B15	0.07	0.08	lasso	2	0.08	2.3e-05	-5.3	-5.3	1.1e-07	0.93	0.01	0.98	FALSE
9	The Cancer Genome Atlas	Rectum Adenocarcinoma	AKR1B15	0.37	0.21	lasso	3	0.21	1.2e-05	-5.3	-5.3	1.3e-07	0.94	0.01	0.95	FALSE
4	GTEx	Heart Left Ventricle	AKR1B1	0.25	0.08	lasso	7	0.05	8.5e-04	-5.0	5.2	1.7e-07	-0.90	0.02	0.97	FALSE
7	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	AKR1B15	0.18	0.12	blup	64	0.14	4.5e-07	-5.3	-5.2	1.8e-07	0.88	0.01	0.99	FALSE
8	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AKR1B15	0.31	0.22	lasso	2	0.20	7.7e-09	-5.3	-5.2	2.2e-07	0.93	0.01	0.99	FALSE
3	GTEx	Heart Atrial Appendage	AKR1B1	0.22	0.21	lasso	4	0.19	6.9e-09	-5.1	5.2	2.3e-07	-0.83	0.02	0.98	FALSE
2	GTEx	Esophagus Mucosa	EXOC4	0.22	0.13	enet	25	0.18	2.0e-12	-4.0	5.2	2.4e-07	-0.20	0.71	0.21	FALSE