[Hub]/) : Traits : High blood pressure :

chr8:8,092,025-13,120,332

Best TWAS P=8.17e-16 · Best GWAS P=8.2e-14 conditioned to 0.000616

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FAM167A 0.09 0.09 lasso 6 0.13 1.4e-15 -3.8 -5.8 7.3e-09 -0.59 0.93 0.07 FALSE
2 CommonMind Brain Pre-frontal Cortex FAM86B1 0.02 0.02 lasso 3 0.01 1.3e-02 6.2 6.9 4.6e-12 0.54 0.16 0.57 FALSE
3 CommonMind Brain Pre-frontal Cortex FAM90A25P 0.11 0.08 lasso 3 0.08 1.4e-09 6.1 6.2 7.1e-10 0.47 0.00 1.00 FALSE
4 CommonMind Brain Pre-frontal Cortex LOC100506990 0.08 0.03 enet 32 0.05 4.1e-07 6.2 6.6 4.8e-11 0.49 0.04 0.96 FALSE
5 GTEx Adipose Subcutaneous FDFT1 0.06 0.04 lasso 3 0.04 3.4e-04 -4.9 5.5 4.3e-08 0.46 0.64 0.22 FALSE
6 GTEx Adipose Subcutaneous ERI1 0.05 0.00 enet 10 0.00 5.5e-01 5.7 -7.0 2.5e-12 -0.49 0.16 0.54 FALSE
7 GTEx Adipose Subcutaneous NEIL2 0.12 0.14 enet 19 0.14 3.3e-11 6.0 6.3 3.3e-10 0.38 0.18 0.82 FALSE
8 GTEx Adipose Subcutaneous AF131215.2 0.24 0.15 lasso 7 0.14 3.5e-11 -5.0 5.7 1.5e-08 0.62 0.99 0.01 FALSE
9 GTEx Adipose Visceral Omentum AF131215.2 0.12 0.08 lasso 6 0.06 4.6e-04 5.4 6.1 1.2e-09 0.66 0.58 0.33 FALSE
10 GTEx Adipose Visceral Omentum AF131215.9 0.18 0.16 lasso 7 0.16 2.0e-08 5.4 5.9 3.0e-09 0.66 0.98 0.02 FALSE
11 GTEx Adrenal Gland AF131215.2 0.20 0.16 enet 12 0.13 2.2e-05 6.0 6.4 1.5e-10 0.66 0.90 0.09 FALSE
12 GTEx Adrenal Gland AF131215.9 0.18 0.16 lasso 10 0.18 3.5e-07 6.0 6.8 1.3e-11 0.67 0.93 0.04 FALSE
13 GTEx Artery Aorta FDFT1 0.09 0.02 lasso 4 0.03 6.1e-03 4.9 7.1 1.1e-12 0.49 0.17 0.36 FALSE
14 GTEx Artery Aorta ERI1 0.11 0.08 lasso 5 0.10 5.1e-06 6.1 -6.7 1.7e-11 -0.54 0.03 0.97 FALSE
15 GTEx Artery Aorta NEIL2 0.30 0.14 lasso 7 0.19 1.7e-10 6.0 5.7 9.2e-09 0.33 0.02 0.98 FALSE
16 GTEx Artery Aorta AF131215.2 0.09 0.09 lasso 7 0.08 2.0e-05 -5.0 6.2 4.6e-10 0.69 0.60 0.36 FALSE
17 GTEx Artery Aorta FAM85A 0.11 0.06 enet 19 0.06 3.4e-04 -5.3 5.2 2.1e-07 0.48 0.51 0.24 FALSE
18 GTEx Artery Aorta AF131215.9 0.13 0.05 lasso 6 0.07 1.3e-04 5.8 6.3 3.9e-10 0.67 0.91 0.04 FALSE
19 GTEx Artery Coronary AF131215.2 0.11 0.02 enet 27 0.05 6.5e-03 -5.3 5.9 3.4e-09 0.67 0.10 0.57 FALSE
20 GTEx Artery Tibial FDFT1 0.14 0.17 lasso 4 0.16 1.1e-12 -4.9 5.1 2.8e-07 0.44 0.98 0.02 FALSE
21 GTEx Artery Tibial ERI1 0.05 0.02 lasso 7 0.01 3.2e-02 6.4 -7.0 2.7e-12 -0.54 0.04 0.92 FALSE
22 GTEx Artery Tibial NEIL2 0.21 0.07 enet 18 0.13 2.8e-10 6.0 6.2 5.2e-10 0.37 0.32 0.68 FALSE
23 GTEx Artery Tibial AF131215.2 0.07 0.03 enet 24 0.05 1.8e-04 -5.8 5.7 9.0e-09 0.65 0.07 0.92 FALSE
24 GTEx Artery Tibial AF131215.9 0.08 0.01 lasso 10 0.02 1.8e-02 -3.1 5.6 2.6e-08 0.63 0.10 0.84 FALSE
25 GTEx Brain Caudate basal ganglia RP11-981G7.6 0.21 0.01 enet 17 0.12 2.3e-04 5.1 5.6 2.5e-08 0.44 0.20 0.12 FALSE
26 GTEx Brain Cerebellar Hemisphere FAM86B3P 0.28 0.27 lasso 8 0.28 5.4e-08 5.9 -5.9 4.0e-09 -0.55 0.45 0.51 FALSE
27 GTEx Brain Cerebellar Hemisphere AF131215.2 0.15 0.17 lasso 3 0.09 3.0e-03 -5.8 6.4 1.1e-10 0.60 0.26 0.15 FALSE
28 GTEx Brain Cerebellum FAM86B3P 0.19 0.14 lasso 5 0.16 1.8e-05 4.8 -5.3 1.5e-07 -0.57 0.60 0.32 FALSE
29 GTEx Brain Cortex FAM86B3P 0.14 0.05 enet 9 0.07 5.1e-03 5.2 -5.5 4.0e-08 -0.55 0.21 0.08 FALSE
30 GTEx Brain Frontal Cortex BA9 FAM86B3P 0.16 0.13 enet 27 0.10 1.1e-03 4.9 -5.1 2.8e-07 -0.50 0.28 0.30 FALSE
31 GTEx Breast Mammary Tissue AF131215.2 0.16 0.15 lasso 6 0.12 1.1e-06 -5.0 6.1 1.3e-09 0.69 0.84 0.11 FALSE
32 GTEx Breast Mammary Tissue AF131215.9 0.10 0.10 lasso 8 0.12 8.7e-07 -5.9 6.6 3.7e-11 0.72 0.73 0.24 FALSE
33 GTEx Breast Mammary Tissue (Male) FAM85A 0.14 0.03 enet 16 0.09 4.3e-03 -5.2 5.9 4.8e-09 0.49 0.08 0.32 FALSE
34 GTEx Breast Mammary Tissue (Female) AF131215.2 0.04 -0.01 lasso 2 0.00 4.8e-01 -5.9 5.9 4.0e-09 0.68 0.08 0.10 FALSE
35 GTEx Breast Mammary Tissue (Female) AF131215.9 0.04 -0.01 enet 6 0.02 7.3e-02 -4.6 6.4 2.1e-10 0.62 0.08 0.18 FALSE
36 GTEx Cells EBV-transformed lymphocytes AF131215.2 0.20 0.10 enet 14 0.11 1.5e-04 -5.8 6.1 1.2e-09 0.64 0.44 0.47 FALSE
37 GTEx Cells EBV-transformed lymphocytes AF131215.9 0.20 0.15 enet 19 0.13 5.6e-05 -5.8 5.8 8.7e-09 0.61 0.59 0.21 FALSE
38 GTEx Cells Transformed fibroblasts ERI1 0.34 0.35 lasso 7 0.35 1.9e-27 6.1 -7.0 2.6e-12 -0.52 0.07 0.93 FALSE
39 GTEx Cells Transformed fibroblasts FAM86B3P 0.23 0.33 lasso 11 0.38 8.4e-30 4.3 5.1 2.9e-07 0.57 0.95 0.05 FALSE
40 GTEx Colon Sigmoid AF131215.2 0.10 0.00 enet 7 0.02 5.0e-02 5.8 6.5 9.7e-11 0.63 0.19 0.29 FALSE
41 GTEx Colon Sigmoid AF131215.9 0.11 0.17 enet 5 0.09 4.9e-04 -5.8 6.2 7.4e-10 0.62 0.38 0.15 FALSE
42 GTEx Colon Transverse AF131215.2 0.15 0.09 enet 32 0.07 3.1e-04 5.8 5.7 1.1e-08 0.67 0.31 0.61 FALSE
43 GTEx Colon Transverse AF131215.9 0.12 0.14 enet 18 0.12 4.0e-06 -5.8 5.7 1.2e-08 0.63 0.67 0.30 FALSE
44 GTEx Colon Transverse RP11-375N15.2 0.09 0.10 lasso 5 0.07 2.4e-04 5.4 6.2 4.4e-10 0.34 0.23 0.71 FALSE
45 GTEx Esophagus Gastroesophageal Junction MSRA 0.11 -0.01 enet 30 -0.01 8.0e-01 5.9 -8.1 8.2e-16 -0.44 0.17 0.14 TRUE
46 GTEx Esophagus Gastroesophageal Junction AF131215.2 0.13 0.06 enet 10 0.11 6.4e-05 5.6 6.7 1.7e-11 0.65 0.56 0.05 FALSE
47 GTEx Esophagus Mucosa AF131215.2 0.15 0.14 enet 15 0.18 4.3e-12 -5.5 6.3 3.7e-10 0.63 1.00 0.00 FALSE
48 GTEx Esophagus Mucosa AF131215.9 0.18 0.16 lasso 14 0.19 1.6e-12 6.2 6.7 2.2e-11 0.69 0.90 0.10 FALSE
49 GTEx Esophagus Muscularis ERI1 0.12 0.09 enet 13 0.08 7.7e-06 6.4 -6.7 2.3e-11 -0.53 0.03 0.97 FALSE
50 GTEx Esophagus Muscularis NEIL2 0.18 0.08 lasso 5 0.04 1.1e-03 -4.6 5.2 2.5e-07 0.38 0.29 0.37 FALSE
51 GTEx Esophagus Muscularis AF131215.2 0.10 0.08 lasso 5 0.09 2.3e-06 -5.6 6.2 5.6e-10 0.61 0.90 0.07 FALSE
52 GTEx Esophagus Muscularis FAM85A 0.10 0.01 enet 20 0.04 2.7e-03 -5.3 5.4 8.7e-08 0.42 0.28 0.47 FALSE
53 GTEx Esophagus Muscularis AF131215.9 0.14 0.17 enet 16 0.17 1.6e-10 -5.8 6.7 2.2e-11 0.67 0.92 0.08 FALSE
54 GTEx Heart Atrial Appendage NEIL2 0.19 0.20 lasso 4 0.24 4.0e-11 5.9 5.8 6.6e-09 0.37 0.32 0.68 FALSE
55 GTEx Heart Atrial Appendage AF131215.2 0.39 0.13 enet 26 0.21 6.6e-10 -5.6 6.4 1.8e-10 0.60 0.90 0.10 FALSE
56 GTEx Heart Atrial Appendage AF131215.9 0.24 0.17 enet 26 0.18 1.3e-08 -5.5 6.8 8.9e-12 0.60 0.85 0.15 FALSE
57 GTEx Heart Atrial Appendage RP11-981G7.6 0.19 0.01 lasso 6 0.04 5.3e-03 -4.8 5.4 7.3e-08 0.48 0.18 0.04 FALSE
58 GTEx Heart Left Ventricle AF131215.2 0.05 0.01 enet 11 0.01 1.5e-01 5.4 6.4 1.3e-10 0.66 0.36 0.24 FALSE
59 GTEx Heart Left Ventricle AF131215.9 0.07 0.10 enet 8 0.10 9.4e-06 -5.8 6.5 9.7e-11 0.65 0.66 0.26 FALSE
60 GTEx Lung ERI1 0.13 0.07 lasso 6 0.09 2.7e-07 -5.4 -6.8 1.3e-11 -0.54 0.21 0.79 FALSE
61 GTEx Lung AF131215.2 0.12 0.08 lasso 5 0.08 1.0e-06 -5.8 5.9 3.7e-09 0.60 0.98 0.02 FALSE
62 GTEx Lung AF131215.9 0.15 0.18 lasso 4 0.15 1.5e-11 -5.8 5.9 4.0e-09 0.59 1.00 0.00 FALSE
63 GTEx Muscle Skeletal MFHAS1 0.07 0.04 lasso 4 0.04 1.4e-04 4.6 6.0 2.3e-09 0.53 0.16 0.82 FALSE
64 GTEx Muscle Skeletal NEIL2 0.11 0.08 lasso 5 0.05 4.7e-06 7.0 7.0 3.3e-12 0.40 0.00 1.00 FALSE
65 GTEx Nerve Tibial ERI1 0.07 0.01 enet 16 0.01 4.2e-02 -4.9 -7.0 3.1e-12 -0.51 0.08 0.79 FALSE
66 GTEx Nerve Tibial NEIL2 0.34 0.20 lasso 6 0.25 8.1e-18 6.0 6.0 2.1e-09 0.37 0.04 0.96 FALSE
67 GTEx Nerve Tibial AF131215.2 0.19 0.18 lasso 12 0.23 3.5e-16 -5.6 6.6 5.5e-11 0.69 0.98 0.02 FALSE
68 GTEx Nerve Tibial AF131215.9 0.17 0.17 lasso 4 0.18 5.0e-13 -5.8 5.9 3.0e-09 0.60 1.00 0.00 FALSE
69 GTEx Ovary NEIL2 0.47 0.32 lasso 7 0.26 5.7e-07 6.0 6.1 1.1e-09 0.34 0.02 0.98 FALSE
70 GTEx Pancreas ERI1 0.08 0.00 enet 16 0.04 6.6e-03 4.5 -5.5 3.9e-08 -0.48 0.14 0.37 FALSE
71 GTEx Pancreas NEIL2 0.32 0.04 lasso 8 0.02 5.6e-02 5.4 5.4 7.3e-08 0.31 0.04 0.73 FALSE
72 GTEx Pancreas AF131215.2 0.16 0.16 enet 17 0.15 9.1e-07 -5.8 6.5 1.1e-10 0.65 0.97 0.02 FALSE
73 GTEx Pancreas AF131215.9 0.25 0.24 enet 14 0.22 1.0e-09 5.8 6.2 5.1e-10 0.66 0.99 0.01 FALSE
74 GTEx Pituitary FAM86B3P 0.13 0.15 lasso 4 0.13 3.5e-04 -4.7 -5.1 3.0e-07 -0.48 0.12 0.58 FALSE
75 GTEx Prostate AF131215.2 0.18 0.02 lasso 6 0.02 9.6e-02 5.9 7.3 3.9e-13 0.86 0.09 0.44 FALSE
76 GTEx Skin Not Sun Exposed Suprapubic AF131215.2 0.16 0.11 enet 21 0.20 3.9e-11 -5.5 6.3 3.8e-10 0.66 0.98 0.02 FALSE
77 GTEx Skin Not Sun Exposed Suprapubic AF131215.9 0.17 0.14 lasso 8 0.19 9.4e-11 -5.8 6.2 7.0e-10 0.64 0.98 0.02 FALSE
78 GTEx Skin Sun Exposed Lower leg MSRA 0.10 0.02 lasso 4 0.01 8.5e-02 2.4 -5.5 4.9e-08 -0.57 0.26 0.42 FALSE
79 GTEx Skin Sun Exposed Lower leg AF131215.2 0.14 0.11 lasso 9 0.16 4.3e-13 -5.5 5.8 5.7e-09 0.64 1.00 0.00 FALSE
80 GTEx Skin Sun Exposed Lower leg AF131215.9 0.19 0.17 enet 29 0.21 3.9e-17 -5.8 6.3 2.2e-10 0.67 1.00 0.00 FALSE
81 GTEx Small Intestine Terminal Ileum AF131215.9 0.14 0.11 enet 16 0.06 1.6e-02 -4.2 6.1 1.1e-09 0.63 0.14 0.34 FALSE
82 GTEx Spleen AF131215.2 0.16 0.08 enet 14 0.06 1.1e-02 -5.8 6.3 2.3e-10 0.67 0.31 0.24 FALSE
83 GTEx Spleen AF131215.9 0.34 0.23 enet 16 0.15 1.2e-04 5.7 5.6 1.8e-08 0.64 0.60 0.10 FALSE
84 GTEx Stomach AF131215.2 0.25 0.03 enet 22 0.14 5.2e-07 -3.2 5.8 6.5e-09 0.55 0.77 0.21 FALSE
85 GTEx Stomach AF131215.9 0.14 0.06 enet 19 0.06 6.7e-04 -5.8 6.6 5.7e-11 0.59 0.60 0.24 FALSE
86 GTEx Testis FAM86B3P 0.15 0.14 lasso 7 0.13 2.2e-06 5.2 -5.4 7.4e-08 -0.54 0.76 0.22 FALSE
87 GTEx Testis SGK223 0.29 0.02 enet 19 0.07 3.5e-04 4.0 -5.3 1.1e-07 -0.44 0.12 0.56 FALSE
88 GTEx Testis AF131215.9 0.12 0.21 lasso 4 0.14 5.6e-07 -5.5 5.7 1.3e-08 0.57 0.98 0.01 FALSE
89 GTEx Thyroid NEIL2 0.14 0.08 enet 8 0.09 2.9e-07 5.4 5.6 1.9e-08 0.39 0.06 0.94 FALSE
90 GTEx Thyroid SGK223 0.19 0.35 enet 16 0.36 1.1e-28 5.5 -6.0 2.6e-09 -0.56 0.85 0.15 FALSE
91 GTEx Thyroid AF131215.2 0.11 0.15 enet 17 0.18 1.2e-13 -5.5 6.7 1.6e-11 0.67 0.96 0.04 FALSE
92 GTEx Thyroid AF131215.9 0.11 0.08 enet 16 0.17 4.7e-13 -5.8 5.9 4.8e-09 0.64 0.98 0.02 FALSE
93 GTEx Uterus AF131215.2 0.17 0.07 enet 13 0.09 7.1e-03 6.0 6.3 3.9e-10 0.73 0.13 0.54 FALSE
94 GTEx Uterus AF131215.9 0.16 -0.01 enet 18 0.03 7.5e-02 6.0 6.3 3.6e-10 0.65 0.12 0.50 FALSE
95 GTEx Vagina AF131215.9 0.21 0.11 lasso 9 0.08 6.3e-03 6.0 6.2 4.8e-10 0.65 0.18 0.65 FALSE
96 GTEx Whole Blood NEIL2 0.09 0.01 enet 15 0.03 1.5e-03 -4.6 5.4 5.5e-08 0.45 0.03 0.94 FALSE
97 NTR Blood MFHAS1 0.02 0.01 blup 759 0.01 2.9e-04 6.1 5.6 2.2e-08 0.54 0.20 0.80 FALSE
98 NTR Blood MSRA 0.02 0.01 blup 833 0.01 2.3e-05 5.2 -7.9 2.6e-15 -0.67 0.59 0.40 FALSE
99 NTR Blood NEIL2 0.04 0.03 lasso 5 0.02 3.0e-07 7.0 6.9 6.7e-12 0.33 0.00 1.00 TRUE
100 ROSMAP Brain Pre-frontal Cortex MTMR9 0.07 0.06 enet 16 0.08 9.5e-11 -4.5 -5.4 5.6e-08 -0.56 1.00 0.00 FALSE
101 ROSMAP Brain Pre-frontal Cortex FAM167A 0.12 0.03 bslmm 620 0.08 1.3e-10 3.6 -6.2 4.7e-10 -0.55 0.07 0.93 FALSE
102 ROSMAP Brain Pre-frontal Cortex NEIL2 0.21 0.12 lasso 7 0.16 4.8e-20 -3.8 5.2 1.6e-07 0.29 1.00 0.00 FALSE
103 ROSMAP Brain Pre-frontal Cortex XKR6 0.11 0.10 enet 23 0.13 1.2e-16 -5.6 7.3 2.6e-13 0.65 0.54 0.46 FALSE
104 ROSMAP Brain Pre-frontal Cortex FAM86B3P 0.19 0.27 bslmm 331 0.27 5.6e-35 5.2 -5.5 3.1e-08 -0.44 0.92 0.08 FALSE
105 ROSMAP Brain Pre-frontal Cortex FAM66A 0.23 0.26 enet 29 0.30 4.7e-39 6.1 6.0 1.7e-09 0.50 0.00 1.00 FALSE
106 ROSMAP Brain Pre-frontal Cortex RP11-62H7.2 0.36 0.35 enet 35 0.39 1.7e-53 4.6 5.3 9.8e-08 0.49 1.00 0.00 FALSE
107 ROSMAP Brain Pre-frontal Cortex AF131215.3 0.08 0.10 lasso 7 0.12 8.3e-16 6.3 6.8 1.4e-11 0.70 0.89 0.11 FALSE
108 ROSMAP Brain Pre-frontal Cortex AF131215.2 0.49 0.57 lasso 7 0.57 9.0e-89 -5.8 5.9 3.2e-09 0.60 1.00 0.00 FALSE
109 ROSMAP Brain Pre-frontal Cortex FAM85A 0.11 0.07 enet 23 0.11 4.3e-14 6.1 6.4 1.3e-10 0.52 0.03 0.97 FALSE
110 The Cancer Genome Atlas Bladder Urothelial Carcinoma ERI1 0.05 0.01 blup 72 0.01 5.0e-02 6.1 -5.7 1.4e-08 -0.38 0.01 0.80 FALSE
111 The Cancer Genome Atlas Breast Invasive Carcinoma FDFT1 0.02 0.00 blup 110 0.01 1.1e-02 -3.2 -5.5 3.9e-08 -0.44 0.02 0.79 FALSE
112 The Cancer Genome Atlas Breast Invasive Carcinoma RP1L1 0.02 0.01 lasso 2 0.01 4.1e-03 6.0 6.7 2.5e-11 0.55 0.02 0.79 FALSE
113 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NEIL2 0.05 0.07 enet 5 0.08 8.1e-09 5.9 6.6 5.3e-11 0.39 0.00 1.00 FALSE
114 The Cancer Genome Atlas Brain Lower Grade Glioma FLJ10661 0.21 0.26 lasso 9 0.30 2.3e-34 4.4 -5.2 2.4e-07 -0.55 0.04 0.94 FALSE
115 The Cancer Genome Atlas Brain Lower Grade Glioma NEIL2 0.08 0.08 enet 6 0.08 1.7e-09 6.0 6.0 1.5e-09 0.29 0.11 0.89 FALSE
116 The Cancer Genome Atlas Lung Adenocarcinoma ERI1 0.06 0.04 blup 72 0.04 1.5e-05 6.3 -6.1 1.2e-09 -0.46 0.01 0.99 FALSE
117 The Cancer Genome Atlas Lung Squamous Cell Carcinoma AMAC1L2 0.03 0.03 blup 55 0.04 3.0e-05 5.0 -5.2 2.4e-07 -0.56 0.01 0.98 FALSE
118 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma FAM167A 0.29 0.24 lasso 2 0.27 3.5e-11 6.1 6.1 7.8e-10 0.48 0.01 0.99 FALSE
119 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma FLJ10661 0.25 0.18 lasso 4 0.16 4.2e-07 4.9 -5.3 1.3e-07 -0.54 0.00 0.99 FALSE
120 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma TDH 0.31 0.10 lasso 3 0.13 1.1e-05 6.1 5.8 6.0e-09 0.44 0.00 0.99 FALSE
121 The Cancer Genome Atlas Testicular Germ Cell Tumors ZNF705D 0.23 0.20 lasso 3 0.24 4.7e-09 6.1 -5.5 4.8e-08 -0.45 0.00 1.00 FALSE
122 The Cancer Genome Atlas Thyroid Carcinoma NEIL2 0.14 0.08 blup 97 0.10 6.3e-10 5.9 5.4 5.1e-08 0.32 0.04 0.96 FALSE
123 The Cancer Genome Atlas Thyroid Carcinoma SGK223 0.16 0.20 enet 14 0.22 6.1e-21 -4.7 -5.5 4.2e-08 -0.52 0.97 0.03 FALSE