Hub : Genes

AKR1B1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2424	0.0991	4.7e-03	0.075	NA	0.141	NA	0.050	1.2e-03	NA	9.3e-06	NA	6.8e-03
2	GTEx	Heart Atrial Appendage	0.2220	0.0740	8.7e-04	0.211	NA	0.140	NA	0.189	7.6e-10	NA	7.7e-07	NA	6.9e-09
3	GTEx	Heart Left Ventricle	0.2462	0.0850	2.3e-03	0.079	NA	0.037	NA	0.053	5.6e-05	NA	4.6e-03	NA	8.5e-04
4	GTEx	Thyroid	0.2310	0.0630	1.2e-05	0.132	NA	0.107	NA	0.121	2.7e-10	NA	1.4e-08	NA	1.6e-09
5	ROSMAP	Brain Pre-frontal Cortex	0.0287	0.0140	1.6e-02	0.026	0.007	0.009	0.009	0.014	2.4e-04	3.4e-02	2.1e-02	2.2e-02	5.1e-03
6	YFS	Blood	0.0757	0.0177	5.6e-17	0.043	0.067	0.079	0.075	0.077	7.7e-14	6.9e-21	1.5e-24	2.4e-23	5.1e-24
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0397	0.0226	3.7e-03	0.035	0.015	0.011	NA	0.018	7.6e-05	6.7e-03	1.8e-02	NA	3.9e-03
8	TCGA	Brain Lower Grade Glioma	0.1214	0.0544	2.9e-04	0.014	0.052	0.050	NA	0.033	7.9e-03	1.5e-06	2.1e-06	NA	1.0e-04
9	TCGA	Thyroid Carcinoma	0.1260	0.0450	9.2e-08	0.037	0.072	0.068	NA	0.049	1.6e-04	1.5e-07	3.3e-07	NA	1.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.5	0.8	1.5	0.5	-1.1	-0.8	-0.8	-0.5	1.2	1.2	-1.0	-0.5
Bipolar Disorder or Schizophrenia	0.7	1.7	7.6	0.4	-1.3	-0.8	0.1	-1.3	2.8	1.5	-0.8	0.1
Depressed Affect (Nagel 2018)	0.5	1.0	3.6	0.8	1.1	1.1	1.9	0.4	-0.0	-0.9	-0.0	1.2
Depression (Nagel 2018)	0.5	0.7	2.0	0.7	1.3	1.2	0.1	0.5	-0.3	-1.4	0.7	0.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	4.9	-2.2	-0.3	-0.6	0.2	-0.4	0.7	1.2	0.4	0.0
Neuroticism (Nagel 2018)	0.2	0.5	1.6	-0.2	0.5	0.4	1.3	-0.0	-0.4	-1.2	0.5	0.9
Schizophrenia (2018)	0.6	1.2	6.4	-0.2	-0.8	-0.4	0.8	-1.2	2.5	1.0	-0.3	0.6
Schizophrenia vs Biploar Disorder	0.4	0.5	1.2	-0.9	0.3	-0.0	-0.7	-0.5	0.6	-1.1	0.3	-1.1
Worry (Nagel 2018)	0.5	1.0	2.8	0.5	0.6	0.7	1.3	0.2	-1.5	-1.7	0.3	1.0
Alzheimer’s Disease (in mother)	0.3	0.4	2.1	-0.1	-0.7	-0.4	0.3	-0.1	0.4	-0.6	-1.5	0.2
Alzheimer’s Disease (in father)	0.2	0.2	0.5	-0.5	0.4	0.4	-0.1	-0.4	0.7	-0.0	0.4	-0.2
Alzheimer’s Disease (including proxy)	0.5	0.7	3.6	-0.3	-0.7	-0.6	0.3	-1.1	0.3	-0.8	-1.9	-0.1
Crohns Disease (2017)	1.8	3.9	8.0	-2.8	-2.1	-1.7	0.3	-2.2	2.1	2.8	0.1	1.6
Irritable Bowel Disease (IBD)	1.6	3.8	12.9	-1.5	-2.0	-1.8	-0.1	-2.0	2.5	3.6	-0.6	1.2
Ulcerative Colitis (UC)	0.7	1.4	6.5	0.3	-0.8	-0.8	0.2	-0.6	1.8	2.5	-0.9	0.8
Major Depression (MDD)	1.0	1.2	2.7	1.6	1.0	1.0	-0.0	0.8	-1.3	-1.1	-0.9	-1.4
Reaction Time	0.4	0.8	3.5	-1.5	0.4	0.1	-0.7	-0.1	0.5	0.3	1.9	1.0
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.6	-1.3	1.1	0.9	-0.5	0.4	-0.4	1.3	1.1	-0.2
Breast Cancer	0.1	0.2	0.6	-0.5	-0.8	-0.6	-0.3	-0.2	0.0	0.4	-0.7	-0.5
Ovarian Cancer	0.9	1.2	4.6	0.0	-1.4	-1.0	-2.1	-1.0	0.5	-0.5	0.6	-1.1
Prostate Cancer	0.3	0.4	0.9	0.1	0.8	0.6	0.7	0.3	-0.7	0.1	0.9	0.6
Age at First Birth	0.3	0.5	0.8	-0.1	-0.7	-0.9	-0.8	0.6	0.8	0.9	0.1	-0.5
Bipolar Disorder (2011)	0.4	0.4	1.2	0.5	0.7	1.1	-0.5	0.5	0.9	0.1	0.4	-0.4
Body Mass Index (BMI) (2010)	0.1	0.1	0.8	-0.9	-0.3	-0.1	-0.5	-0.3	0.0	0.2	0.0	0.0
Coronary Artery Disease (CAD)	1.2	1.5	5.8	0.7	1.0	1.1	1.4	2.4	-1.0	-0.7	-0.4	1.0
Crohns Disease (2012)	0.7	1.1	3.5	-1.9	-0.5	-0.7	0.1	-0.9	1.4	1.8	-0.1	-0.0
Mean Putamen Volume	0.1	0.1	0.9	-0.3	0.1	0.3	-0.1	0.3	0.4	0.0	0.9	0.1
Fasting Glucose	0.4	0.5	2.0	0.5	0.6	0.6	-0.5	1.0	-0.4	-1.4	-0.4	-0.4
HbA1C	0.6	0.7	1.7	-0.8	-0.8	-0.7	-1.3	-1.3	0.6	0.4	-0.1	-0.5
HDL Cholesterol	0.5	0.9	2.6	0.5	1.0	1.3	1.0	1.0	-1.6	-0.4	-0.1	0.2
LDL Cholesterol	0.3	0.4	1.0	-0.3	0.3	0.3	-1.0	0.6	0.0	-0.6	0.9	-1.0
Lupus	0.5	0.8	2.3	0.0	-0.3	-0.2	-1.0	-1.0	1.5	1.3	0.8	0.1
Neuroticism (2016)	0.9	1.2	3.5	0.2	-1.1	-1.2	-1.9	-1.6	0.5	1.0	-0.1	-1.1
Primary Biliary Cirrhosis	0.9	1.3	4.2	-0.2	-0.7	-1.0	-1.2	-1.4	2.0	1.4	0.7	0.1
Rheumatoid Arthritis	0.4	0.5	1.4	0.4	-0.8	-0.8	0.8	-0.7	0.1	-0.4	-0.7	1.2
Schizophrenia (2014)	0.2	0.4	1.7	0.4	-0.0	0.2	0.5	-0.3	1.3	-0.3	-1.1	-0.5
Triglycerides	1.6	2.7	6.7	-1.2	-2.2	-2.6	-0.0	-1.7	1.9	1.9	-1.2	-0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	0.9	-0.3	-0.4	-0.3	0.5	0.5	0.1	-0.4	0.1
Ulcerative Colitis	0.5	0.7	2.7	0.8	-0.1	-0.2	-0.9	-0.1	1.3	1.6	-0.6	-0.5
Blood Eosinophil Count	0.2	1.4	3.1	0.3	1.7	1.8	-0.3	0.7	-1.2	-1.5	-1.2	-0.8
Blood Platelet Count	0.2	2.0	5.2	-1.6	0.2	-0.2	0.6	-1.3	2.3	0.2	1.7	2.3
Blood Red Count	0.1	0.9	2.1	-1.3	-1.1	-1.4	-1.0	-0.5	0.4	0.9	-0.3	-1.0
Blood White Count	0.1	1.0	4.0	0.0	0.9	0.9	1.1	0.1	0.1	-0.8	1.3	2.0
Heel T-Score	0.1	0.6	2.3	-0.2	0.2	-0.1	-0.6	0.4	-1.5	-0.4	-0.4	-1.4
BMI	0.1	0.3	2.0	-0.5	0.3	-0.1	-0.3	-0.6	0.3	0.4	1.4	0.3
Height	0.1	1.0	3.8	-1.5	0.6	-0.0	-1.3	-0.5	-0.1	-0.1	0.5	-2.0
Waist Hip Ratio (WHR)	0.1	0.6	1.3	-1.1	-0.2	-0.1	-0.5	-1.0	1.1	0.0	1.1	0.3
Systolic Blood Pressure	4.7	23.3	49.1	1.6	6.5	7.0	3.6	6.4	-5.5	-4.9	2.4	1.2
Smoking Status	0.5	1.3	2.6	0.9	-1.6	-1.6	-0.3	-1.6	0.8	0.1	-1.5	-0.1
Allergy or Eczema	0.2	0.6	2.1	1.2	0.0	0.5	-0.6	0.4	0.5	-0.5	-1.0	-1.5
Cardiovascular Disease	4.4	14.4	29.2	3.7	5.1	5.4	1.3	5.0	-4.2	-3.6	1.4	-0.7
Hypothyroidism (self reported)	0.2	0.6	1.3	-0.7	-1.0	-1.1	0.1	-0.7	0.6	1.0	-0.5	-0.3
Respiratory disease	0.4	1.0	4.8	-0.8	0.4	0.8	0.9	0.0	-0.4	-1.1	-2.2	-0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.1	-0.1	1.4	1.2	-0.6	0.4	0.4	-1.5	0.7	0.6
Lung FEV1/FVC ratio	0.2	1.3	3.3	-0.5	0.1	-0.7	-1.8	-0.6	0.3	1.8	1.6	1.0
Lung FVC	1.0	5.3	9.6	1.0	2.8	3.0	0.9	3.0	-3.1	-2.6	1.4	1.1
Neuroticism	0.1	0.4	1.1	0.3	-0.0	-0.0	0.6	-0.9	0.3	-1.1	0.3	0.9
Chronotype (morning person)	0.4	0.9	3.1	-0.4	0.6	0.8	1.2	1.1	0.7	0.3	0.9	1.7
Hair Pigment	0.1	1.5	4.7	-0.7	-1.8	-2.2	1.2	-0.6	0.5	1.5	0.2	1.0
Tanning	0.1	1.2	3.4	0.8	-1.6	-1.5	-0.0	-1.8	0.8	0.7	-1.0	0.5
Hand grip strength (left)	0.6	1.6	5.7	0.9	0.3	0.4	-2.4	0.2	-1.8	-0.9	-0.4	-1.9
Number of treatments/medications taken	0.3	0.5	0.9	0.9	0.4	0.3	0.8	0.8	-0.7	-0.8	-0.7	-0.4
Average weekly spirits intake	0.8	1.0	2.3	-0.1	-1.5	-1.4	0.1	-1.2	1.5	0.9	-0.1	0.4
Sensitivity / hurt feelings	0.7	1.3	4.5	-0.2	1.0	0.9	2.1	0.3	-0.0	-1.4	0.8	1.5
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.7	1.9	1.5	1.6	0.3	0.9	-0.7	-1.9	0.3	0.0
Hearing difficulty/problems: Yes	0.9	1.4	8.3	1.2	-0.4	0.2	2.9	0.2	-0.6	-0.7	-0.8	1.1
Relative age of first facial hair	0.7	1.4	3.2	1.1	-1.2	-1.2	-1.8	-1.0	-0.5	0.6	-1.2	-1.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	3.4	-1.1	-0.8	-0.8	-1.9	-1.3	0.0	0.6	1.0	-1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	0.7	0.3	0.5	-0.1	0.2	-0.8	-0.4	-0.9	-1.0
Ever had hysterectomy (womb removed)	0.9	1.0	3.9	0.6	-0.4	-0.5	1.6	-0.5	0.1	-0.9	-1.0	2.0
Systolic blood pressure, automated reading	1.3	3.8	7.1	-0.3	2.3	2.6	1.9	2.7	-2.6	-1.2	1.8	0.8
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	4.1	0.1	-1.3	-1.7	-0.6	-1.6	2.0	1.0	-0.4	0.2
Angina	0.2	0.2	0.9	-0.5	-0.1	0.0	0.6	-0.6	0.9	0.1	0.0	0.3
Medication for hormone replacement therapy	0.8	0.8	4.8	0.6	-0.3	0.4	2.2	0.5	-0.5	-0.5	-0.9	0.8
Vitamin and mineral supplements	0.5	0.6	2.4	-0.4	0.7	0.6	1.0	0.1	-0.1	-0.6	1.1	1.5
Supplements: Zinc	1.8	1.9	5.0	-0.1	-1.2	-1.4	-1.4	-0.3	0.6	1.4	-2.1	-2.2
Medication: Co-codamol	0.6	0.7	2.4	1.6	-1.0	-1.1	0.0	-0.6	0.2	1.1	-0.6	-0.0
Medication: Metformin	0.5	0.8	2.9	-0.7	0.9	0.5	-0.8	0.5	0.2	-1.7	1.2	0.1
Diabetes (father)	0.2	0.2	0.7	-0.1	-0.1	-0.2	0.0	-0.9	0.7	0.0	-0.7	0.2
Diabetes (mother)	0.4	0.5	1.1	0.3	0.7	0.2	0.7	0.9	-0.5	1.0	-0.9	-0.3
Severe depression (siblings)	0.9	1.0	2.3	-0.5	-1.5	-1.4	0.9	-0.9	1.1	0.7	0.6	1.0
Pack years adult smoking proportion	0.5	0.8	1.5	0.6	1.2	1.1	1.1	0.7	-0.3	-1.0	0.9	0.8
Impedance of leg (right)	0.4	1.9	3.1	-1.7	-1.7	-1.7	0.8	-1.3	1.4	1.4	-1.3	0.2
Leg fat-free mass (left)	0.1	0.5	2.6	0.2	0.4	-0.0	-1.6	-0.3	-0.3	-0.0	1.2	-0.6
Trunk fat percentage	1.3	5.1	7.7	-1.9	-2.7	-2.8	-2.5	-2.5	2.6	2.6	-0.7	-1.0
Hand grip strength (right)	0.6	1.7	4.7	0.7	1.0	0.9	-1.9	0.8	-2.2	-1.2	0.3	-1.7
Townsend deprivation index at recruitment	0.2	0.3	0.8	0.4	-0.3	-0.2	0.7	-0.9	0.9	-0.4	-0.4	0.6
Current tobacco smoking	0.5	0.9	2.4	0.9	-1.6	-1.5	0.2	-0.7	0.1	-0.7	-1.1	0.4
Average weekly fortified wine intake	1.5	1.7	4.3	-0.3	-1.3	-1.4	-1.5	-1.3	1.6	2.1	-0.7	-0.7
Maternal smoking around birth	0.7	1.1	3.5	1.0	-0.3	-0.0	1.7	0.1	0.4	-0.6	1.3	1.9
Fed-up feelings	1.1	2.0	5.7	1.1	1.1	1.2	2.4	0.3	-0.6	-2.3	0.5	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	4.0	5.3	12.3	2.8	2.4	2.8	1.7	1.6	-2.6	-3.5	-0.9	-0.6
Relative age voice broke	0.2	0.2	1.5	-0.1	0.0	0.1	-1.2	0.0	-0.4	0.1	0.6	-0.3
Taking other prescription medications	0.1	0.2	1.0	0.4	-0.5	-0.4	1.0	0.1	0.1	-0.0	-0.6	-0.1
Age when periods started (menarche)	0.4	1.0	2.5	-1.2	-0.7	-1.2	0.1	-1.6	1.1	-0.3	0.7	1.2
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	6.9	1.8	0.4	0.6	2.6	0.5	-1.6	-1.6	-1.2	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	-0.5	-0.2	-0.4	-0.7	0.2	-0.6	0.0	-0.7	-1.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	-0.7	-0.4	-0.7	0.8	0.0	0.9	0.7	-0.9	0.5
Qualifications: CSEs or equivalent	1.0	1.3	3.2	-0.2	-1.7	-1.5	-0.5	-1.8	0.6	0.1	-1.5	-0.1
Serious illness, injury or assault to yourself	0.3	0.3	1.1	-0.1	0.5	0.5	-0.3	-0.7	0.4	0.5	-0.5	-1.0
High blood pressure	5.0	13.9	27.4	2.2	5.2	5.2	2.1	4.7	-4.5	-4.2	1.5	0.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.7	1.3	0.4	0.6	-0.3	0.5	-0.4	-0.6	-0.9	-1.2
Multivitamins +/- minerals	0.8	1.0	2.8	-0.0	-0.7	-0.9	-1.5	-0.3	0.5	1.7	-0.2	-1.5
Stomach or abdominal pain in last month	0.1	0.2	0.7	-0.0	-0.1	-0.3	0.7	-0.2	-0.3	0.1	0.3	0.8
Supplements: Glucosamine	0.6	0.7	3.3	0.5	0.2	-0.0	-1.0	0.8	0.0	0.3	-1.2	-1.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.6	-1.3	0.3	0.1	0.2	1.1	0.7	0.3	0.9	0.2
Medication: Atenolol	0.9	1.1	4.4	2.1	0.7	1.1	1.1	1.2	-0.4	-0.8	-0.3	0.2
Medication: Levothyroxine sodium	0.5	0.9	2.5	1.5	-0.8	-0.8	0.0	-0.2	0.9	1.2	-1.6	-0.4
Sitting height	0.1	1.0	2.6	-1.2	1.0	0.4	-1.2	0.6	-0.8	-0.4	1.3	-1.6
Chronic bronchitis/emphysema (father)	0.8	1.0	2.1	0.0	1.1	1.5	1.0	1.0	-0.8	-1.1	1.0	0.8
High blood pressure (mother)	1.1	1.6	2.9	0.6	1.3	1.3	1.7	1.5	-0.6	-0.8	1.4	1.5
Body mass index (BMI)	0.1	0.6	1.2	-0.2	-0.9	-0.9	-0.5	-1.1	0.8	1.1	0.3	0.3
Impedance of leg (left)	0.4	2.0	3.5	-1.6	-1.9	-1.9	0.3	-1.5	1.5	1.0	-1.7	-0.1
Leg predicted mass (left)	0.1	0.6	2.8	0.2	0.3	-0.0	-1.7	-0.3	-0.4	-0.1	1.2	-0.7
Trunk fat mass	0.9	3.7	5.9	-1.6	-2.2	-2.4	-2.4	-2.1	2.0	2.2	-0.2	-1.0
Waist circumference	0.9	3.3	7.2	-1.4	-1.8	-2.1	-1.7	-2.7	2.3	2.0	0.7	-0.2
Number of incorrect matches in round	1.0	1.6	5.7	0.6	-1.3	-1.0	2.4	0.1	0.3	-0.3	-1.7	1.8
Past tobacco smoking	0.5	0.8	4.5	0.0	0.5	0.7	2.1	0.9	-0.3	-0.4	-0.1	1.2
Alcohol usually taken with meals	0.3	0.4	2.1	0.4	0.6	1.0	-0.2	1.5	-0.1	0.3	-0.2	-0.2
Nervous feelings	0.3	0.6	1.5	0.7	-0.1	0.1	1.1	0.2	-1.1	-1.2	-0.7	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.4	0.9	0.6	0.7	-0.2	0.2	-0.1	-1.6	-0.5	-0.9
Hearing difficulty/problems with background noise	0.8	1.2	2.2	1.3	1.3	1.5	1.4	1.0	-0.9	-1.2	0.3	-0.3
Hair/balding pattern: Pattern 2	0.8	1.0	3.2	-0.3	-1.8	-1.4	-0.2	-1.2	0.3	0.9	-0.9	-0.1
Had menopause	0.3	0.3	1.0	0.6	-0.2	-0.0	-0.6	1.0	0.1	0.4	-0.4	-0.8
Had other major operations	0.2	0.2	1.3	1.1	0.1	0.3	0.3	0.4	0.1	0.2	-0.4	-0.4
Forced vital capacity (FVC)	0.4	1.7	3.5	0.1	1.7	1.8	-1.2	1.4	-1.9	-1.1	0.4	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.6	-0.3	-0.5	-0.7	0.2	-0.4	0.4	0.3	-0.2
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.9	1.1	-0.6	-0.3	2.0	-0.9	0.9	-0.3	-1.3	1.3
Qualifications: None of the above	0.9	2.0	7.8	-0.0	1.0	1.1	1.4	1.0	-1.8	-2.8	1.1	1.1
Financial difficulties in last 2 years	0.7	0.9	3.3	1.1	0.2	0.3	1.8	-0.3	1.0	-0.5	-1.0	1.1
Mouth/teeth dental problems	0.9	1.3	4.8	-0.6	0.9	1.2	0.9	1.7	-2.2	-0.8	-0.3	0.3
Heart attack	0.8	1.1	4.6	0.5	-0.5	-0.6	-1.1	-0.7	0.0	-0.8	-2.2	-1.4
Allergy	0.4	1.0	3.2	-0.2	-0.5	-0.8	0.2	-0.5	1.0	1.5	1.2	1.8
Pain all over the body in last month	0.7	0.8	2.9	0.3	-0.3	-0.1	-1.4	-0.6	1.1	0.3	1.7	-0.5
Diabetes (self-reported)	0.2	0.2	0.9	0.1	0.0	-0.5	-1.0	-0.1	0.4	-0.8	0.2	0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	0.7	0.5	0.7	-0.3	0.2	-0.4	0.4	0.2	-0.4
Medication: Ramipril	2.4	3.1	6.7	-0.5	2.6	2.4	-0.5	2.2	-1.9	-1.8	1.2	-1.3
Medication: Simvastatin	0.4	0.6	1.5	0.5	0.8	0.9	-0.6	1.2	-0.0	-1.1	0.2	-0.5
Fluid intelligence score	0.5	1.1	2.2	-0.6	1.3	1.5	-1.4	0.5	0.4	0.9	1.5	-0.6
Illnesses of siblings	1.6	2.2	6.4	2.1	-0.7	-0.6	-2.1	-0.4	-0.9	-0.3	-1.6	-2.5
Neuroticism score	0.5	1.1	3.4	1.1	0.5	0.6	1.8	-0.3	-0.4	-1.7	-0.0	1.1
Weight	0.2	1.0	2.9	-0.7	-0.9	-1.2	-1.7	-1.3	0.7	1.0	0.5	-0.8
Impedance of arm (right)	0.7	3.3	6.2	-1.9	-2.2	-2.2	-1.3	-1.8	2.5	2.0	-1.1	-0.4
Arm fat percentage (right)	0.6	2.4	4.1	-0.8	-2.0	-1.9	-1.5	-1.8	1.8	1.9	-0.6	-0.3
Trunk fat-free mass	0.2	1.4	3.2	0.7	1.6	1.1	-0.5	0.9	-1.8	-1.6	0.8	-1.1
Hip circumference	0.5	2.3	4.6	-1.4	-1.4	-1.7	-1.5	-2.1	1.9	1.8	0.5	-0.3
Time employed in main current job	1.3	1.5	4.2	0.1	1.0	1.2	2.1	1.2	-1.0	-1.7	-0.3	1.0
Alcohol intake versus 10 years previously	0.2	0.3	1.1	0.2	-0.8	-1.1	0.2	-0.2	0.4	-0.0	0.0	0.6
Father’s age at death	0.4	0.6	2.2	0.3	0.1	0.7	-0.3	0.3	0.4	-1.0	-1.5	-1.0
Worrier / anxious feelings	0.3	0.6	1.8	-0.3	1.0	1.3	0.6	0.3	-0.5	-1.3	0.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.3	0.8	-0.5	-0.2	0.3	-1.1	1.0	-0.7	-0.5	0.6
Falls in the last year	1.4	1.9	3.9	1.6	1.6	2.0	0.2	1.4	-1.5	-1.8	0.2	-0.8
Hair/balding pattern: Pattern 3	0.3	0.4	0.8	-0.9	-0.6	-0.6	0.7	-0.2	0.7	0.4	-0.7	0.4
Number of live births	1.1	1.6	4.4	-2.0	-0.8	-0.7	-0.2	-1.2	1.1	2.1	1.4	0.4
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.5	0.1	1.8	1.8	-1.4	1.5	-1.9	-0.7	1.3	-0.6
Pulse rate	1.5	2.6	4.8	-0.9	-1.6	-1.8	1.2	-1.8	2.1	1.6	0.6	2.2
Happiness	1.5	1.8	4.3	1.3	1.2	1.8	1.4	0.9	-1.3	-2.1	-1.1	-0.0
Noisy workplace	1.1	1.3	4.2	1.8	-1.1	-1.3	0.7	-0.7	0.3	0.4	-2.0	0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	-0.8	0.3	0.1	-0.8	-0.3	1.0	1.0	-0.3	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.9	-0.1	-0.6	-0.8	0.6	-0.3	0.9	0.3	-0.3	1.0
Mouth/teeth dental problems: Dentures	0.2	0.4	1.7	0.2	-0.1	-0.3	-1.0	-0.8	1.3	-0.2	-0.1	-0.4
Asthma	0.5	0.9	4.7	-0.2	0.3	0.8	0.9	0.1	-0.4	-1.3	-2.2	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.5	1.6	-1.5	-0.9	-0.9	-0.7	-0.4	0.3	-1.1	-0.8
Medication: Cholesterol lowering	0.5	0.8	3.8	0.5	0.1	-0.2	-0.8	1.3	-0.5	0.4	-0.9	-1.9
Depression (self-reported)	0.1	0.1	0.4	0.1	0.1	-0.3	-0.5	-0.0	-0.4	0.2	0.3	-0.6
Medication: Lansoprazole	0.6	0.7	2.2	-1.5	-0.5	-0.8	-0.4	-1.0	1.1	0.4	0.8	0.3
Prospective memory result	0.9	1.1	4.8	1.0	-0.9	-0.9	2.2	-0.6	-0.7	-0.4	-0.9	0.9
Lung cancer (father)	0.4	0.5	1.3	-0.1	-1.1	-1.1	-0.4	-0.6	0.0	-0.2	-1.1	-0.4
Illnesses of mother	1.3	1.6	5.7	-1.8	-0.3	0.1	-0.1	-1.6	1.0	0.3	2.4	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.4	4.7	1.1	2.1	2.0	-1.0	1.8	-2.2	-0.8	1.5	-0.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.4	0.7	0.4	0.5	0.1	0.4	-0.6	-0.2	0.5
Impedance of arm (left)	1.1	5.2	8.6	-2.0	-2.8	-2.6	-2.3	-2.2	2.9	2.6	-1.1	-0.9
Arm fat mass (right)	0.4	1.6	2.6	-0.6	-1.5	-1.5	-1.6	-1.5	1.4	1.4	-0.1	-0.6
Trunk predicted mass	0.2	1.3	2.9	0.7	1.6	1.1	-0.4	0.9	-1.7	-1.5	0.9	-1.0
Standing height	0.2	2.0	8.3	-1.1	0.2	-0.5	-2.9	-0.2	-0.3	-0.3	0.2	-2.8
Length of working week for main job	0.4	0.4	1.3	1.2	0.7	0.9	0.4	-0.0	0.1	-0.8	-0.2	0.4
Exposure to tobacco smoke at home	0.3	0.3	1.0	1.0	0.2	0.4	-0.1	0.4	0.1	-0.6	-0.9	0.6
Breastfed as a baby	0.6	0.8	2.5	-0.6	0.5	0.5	0.7	0.9	-1.3	-0.4	-1.6	-0.8
Tense / ‘highly strung’	0.6	1.0	3.0	1.6	0.8	1.0	0.1	-0.0	-1.4	-1.7	0.3	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.5	1.9	0.6	0.6	0.6	0.1	-0.4	-0.4	-1.3	-1.1
Hair/balding pattern: Pattern 4	0.7	1.6	5.3	0.7	2.3	1.9	0.5	1.1	-0.2	-1.5	1.0	-0.5
Birth weight of first child	0.5	0.9	3.1	-0.4	-1.0	-1.1	-0.2	-0.8	1.7	1.3	0.6	-0.2
Peak expiratory flow (PEF)	0.5	1.1	3.2	0.1	0.9	1.2	-1.8	1.2	-1.3	-0.4	0.6	-0.9
Pulse wave reflection index	1.0	1.2	4.8	2.2	0.9	1.1	0.7	0.8	-0.0	-1.2	-1.3	0.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.4	0.6	-0.7	-0.5	1.1	-0.6	0.5	1.2	-1.1	0.3
Loud music exposure frequency	0.2	0.3	0.8	0.9	0.1	0.3	-0.7	-0.6	0.7	-0.1	-0.0	-0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.9	0.7	0.6	1.0	0.1	0.8	-0.7	-0.5	-0.4	-0.4
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.4	0.3	-1.6	-1.8	0.1	-1.0	1.4	1.4	-0.5	0.4
Blood clot in the leg (DVT)	1.8	2.3	5.4	-0.7	2.3	2.1	-0.0	1.1	-1.8	-1.9	1.3	-0.7
Medication: Paracetamol	0.8	1.3	2.4	-0.6	-1.4	-1.4	-0.6	-1.5	1.6	1.3	0.4	0.6
Headache pain in last month	0.5	0.9	4.3	2.1	0.9	0.5	0.0	1.0	-0.7	-1.0	0.3	-0.0
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.5	-1.4	-1.6	-1.4	-0.8	-1.9	1.4	1.1	1.0	1.2
Glaucoma (self-reported)	0.8	0.9	4.0	-0.5	-0.3	-0.7	-2.0	-0.7	-0.1	0.9	0.3	-1.3
Gout (self-reported)	1.0	1.3	5.2	-0.1	-0.4	-0.6	-2.3	0.2	1.3	1.7	1.3	-0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.2	0.1	-1.0	-1.1	0.3	-0.7	0.9	0.6	-1.1	0.1
Medication: Amlodipine	4.5	6.3	16.3	1.4	2.9	2.9	-0.2	3.3	-4.0	-2.6	2.0	-0.7
Medication: Ventolin 100micrograms inhaler	0.5	0.6	3.2	-1.8	-0.9	-0.7	-0.4	-0.4	0.5	0.3	-0.4	-0.2
Birth weight	0.2	0.4	2.6	-0.4	-0.1	-0.1	-0.3	0.3	0.6	0.6	1.6	0.5
Chronic bronchitis/emphysema (mother)	3.2	3.7	7.4	-0.2	-2.7	-2.7	-1.5	-2.1	2.5	2.0	-1.2	-0.2
High blood pressure (siblings)	2.6	3.8	10.8	-0.8	2.2	2.2	3.3	2.1	-0.6	-0.7	1.7	2.2
Forced vital capacity (FVC), Best measure	0.5	1.9	4.5	1.2	1.7	1.8	-0.9	1.5	-2.1	-0.9	0.9	-0.6
Body fat percentage	1.2	4.6	7.3	-1.7	-2.7	-2.7	-2.0	-2.5	2.6	2.5	-0.7	-0.6
Leg fat percentage (right)	0.7	2.5	5.0	-1.2	-2.1	-2.0	-0.1	-1.8	2.0	2.2	-0.3	0.6
Arm fat-free mass (right)	0.1	0.5	1.1	0.3	0.6	0.3	-0.9	-0.0	-1.1	-0.7	0.6	-0.9
Exposure to tobacco smoke outside home	0.9	1.1	7.6	2.8	-0.1	-0.0	-1.0	0.0	-0.4	0.2	-0.3	-1.2
Comparative body size at age 10	0.3	0.8	3.2	-0.7	-0.2	-0.0	-0.7	-0.8	1.4	-0.1	1.8	0.6
Number of full brothers	0.7	0.8	2.1	-1.4	-1.1	-0.5	0.4	-1.3	0.7	0.4	0.5	1.0
Worry too long after embarrassment	1.0	1.8	3.1	-0.4	1.5	1.5	1.7	1.1	-0.7	-1.6	1.7	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.1	0.4	-0.6	-0.6	1.4	-0.8	-0.1	-0.0	-0.2	0.9
Wheeze or whistling in the chest in last year	1.3	2.2	5.3	-0.4	-2.0	-1.7	-0.6	-2.3	1.3	1.2	-1.8	-0.8
Number of children fathered	0.9	1.0	3.5	0.5	-1.2	-0.9	-1.1	-1.0	0.2	0.4	-0.8	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.6	0.4	-0.5	-0.4	0.9	1.3	-0.2	0.5	-0.5	-0.0
Age at first live birth	0.3	0.5	2.1	-0.6	-0.1	-0.4	-0.6	0.4	0.9	1.4	-0.6	-0.3
Pulse wave peak to peak time	0.2	0.2	0.4	-0.6	-0.5	-0.3	-0.5	-0.1	-0.4	0.5	0.2	-0.7
Health satisfaction	0.5	0.6	2.6	0.7	0.4	0.9	-0.1	0.0	-0.8	-1.6	-0.5	-0.5
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.2	0.5	0.6	-0.3	-0.4	0.2	-0.4	0.7	-0.1
Qualifications: College or University degree	0.3	1.0	4.2	-0.4	0.5	0.4	-2.1	0.1	0.2	0.2	-0.2	-1.9
Eye problems/disorders: None of the above	0.9	1.0	4.4	-0.3	0.3	0.8	1.8	0.5	-0.1	0.0	0.7	2.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.1	1.4	-0.5	-0.4	-0.9	-0.6	0.8	0.7	-0.2	-0.6
Emphysema/chronic bronchitis	0.9	1.0	2.5	1.5	-1.5	-1.0	-0.5	-0.3	-0.4	-0.1	-1.6	-0.9
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	-0.9	0.5	0.2	-0.2	0.7	-0.6	0.1	-0.7	-0.6
Neck or shoulder pain in last month	0.1	0.1	0.8	-0.3	-0.2	-0.1	0.9	-0.2	-0.3	0.1	-0.0	-0.1
Medication: Blood pressure	2.1	3.8	8.4	1.7	2.9	2.8	0.9	2.6	-2.0	-1.9	0.6	-0.3
Angina (self-reported)	0.1	0.1	0.6	-0.4	0.0	0.2	0.2	-0.3	0.8	-0.0	0.3	-0.1
Migraine (self-reported)	1.9	2.3	3.9	1.7	1.7	1.4	1.3	1.9	-2.0	-1.7	0.9	0.4
Medication: Ibuprofen	0.9	1.1	3.5	1.0	-1.9	-1.4	-0.1	-1.3	0.3	0.8	-0.9	0.2
Medication: Allopurinol	1.2	1.6	4.4	0.7	1.3	1.0	-2.1	1.6	-0.3	-0.5	1.8	-0.7
Medication: Omeprazole	0.8	1.0	2.3	-1.3	-0.8	-0.9	-0.4	-1.5	1.4	1.0	0.5	0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.5	-0.7	-0.1	0.0	0.1	0.4	-0.2	-0.6	-0.3	0.1
Mean time to correctly identify matches	0.2	0.3	1.4	-0.5	0.5	0.5	-0.3	0.5	0.2	0.4	1.2	0.5
Heart disease (mother)	0.6	0.7	3.0	1.7	-0.2	-0.4	-0.7	0.8	-0.6	-0.2	-1.0	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.9	0.8	0.7	1.0	0.2	0.8	-0.3	-0.5	0.1	-0.3
Whole body fat mass	0.7	2.9	5.0	-1.2	-1.9	-2.0	-2.2	-1.9	1.9	1.9	-0.2	-0.9
Leg fat mass (right)	0.5	1.9	3.5	-0.9	-1.8	-1.9	-0.6	-1.8	1.6	1.9	-0.1	0.2
Arm predicted mass (right)	0.1	0.4	0.8	0.4	0.6	0.2	-0.7	0.0	-0.9	-0.6	0.5	-0.8
Pulse rate, automated reading	1.2	3.9	7.7	-1.7	-2.3	-2.8	0.3	-2.8	2.1	2.1	0.7	1.7
Alcohol intake frequency.	0.6	1.4	4.7	-0.8	-1.8	-2.2	0.1	-1.3	1.1	0.9	-0.3	0.4
Comparative height size at age 10	0.1	0.8	2.9	-1.7	0.9	0.1	-1.2	0.0	-0.3	-0.8	0.7	-0.9
Number of full sisters	1.1	1.3	2.9	-0.4	-1.3	-1.6	-0.3	-1.5	0.6	1.7	1.1	0.7
Suffer from ‘nerves’	0.5	0.8	2.1	1.5	0.6	0.7	0.2	0.4	-1.4	-1.3	0.1	-0.7
Overall health rating	0.1	0.2	1.0	0.7	0.2	0.5	0.1	-0.3	-0.3	-1.0	-0.2	0.0
Chest pain or discomfort	0.3	0.4	1.1	-1.1	-0.5	-0.3	0.9	-0.7	0.8	0.3	-0.1	0.3
Had major operations	0.5	0.6	1.5	0.1	-0.8	-1.0	-1.2	-1.2	-0.0	0.6	0.0	-1.0
Age at last live birth	0.5	0.7	3.3	-1.8	0.4	0.3	-0.6	-0.3	0.8	1.0	0.7	0.2
Family relationship satisfaction	1.0	1.2	4.8	2.0	0.1	0.6	0.4	0.2	0.0	0.2	-2.2	-1.3
Leg pain on walking	0.2	0.2	1.1	-0.1	0.1	0.0	-1.1	-0.0	0.1	-0.3	-0.0	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.9	1.4	0.1	0.0	0.9	-0.6	-0.2	-0.0	-0.9	0.4
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.3	-0.6	-0.2	-0.8	-0.1	-1.0	1.2	1.5	-0.7	0.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.4	-0.7	-0.6	-0.8	-1.5	0.2	-0.5	1.1	1.5	-0.6
Medication: Aspirin	1.9	2.5	4.3	1.7	1.9	2.0	0.4	1.8	-1.8	-2.1	-0.6	-1.1
Supplements: Vitamin C	1.4	1.7	4.2	1.1	0.3	0.5	0.1	1.2	-2.1	-1.6	-2.1	-1.2
Knee pain experienced in last month	0.5	0.8	2.0	-1.0	-1.4	-1.4	-0.4	-1.2	0.5	-0.4	-0.7	-0.3
Hypertension (Self-reported)	5.8	16.1	32.7	2.9	5.6	5.7	2.1	5.0	-4.8	-4.3	1.2	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	4.4	0.5	1.5	1.5	-0.1	1.5	-2.1	-1.3	-0.1	-1.2
Illnesses of father: Heart disease	0.9	1.3	3.3	-0.3	-1.8	-1.6	-0.3	-0.8	1.7	1.0	0.3	0.9
Illnesses of siblings: Diabetes	1.7	2.0	4.1	-2.0	-1.8	-1.9	-0.2	-1.0	1.0	1.9	0.6	1.2
Smoking status: Previous	0.5	0.8	4.0	0.6	0.1	0.1	-2.0	-0.3	0.1	0.5	-0.1	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.8	-0.7	-0.5	-0.6	-0.9	-1.3	-0.5	-0.4	-0.1	-0.6
Whole body fat-free mass	0.1	0.8	1.5	0.4	1.1	0.7	-0.9	0.4	-1.2	-1.0	1.1	-0.9
Leg fat-free mass (right)	0.1	0.7	3.4	0.5	0.5	0.1	-1.8	-0.1	-0.6	-0.3	1.0	-0.9
Arm fat percentage (left)	0.9	3.7	6.4	-0.9	-2.5	-2.4	-2.0	-2.1	2.3	2.4	-0.5	-0.5
Average weekly red wine intake	0.9	1.3	3.4	1.4	0.8	1.3	1.8	1.6	-1.0	0.0	-0.9	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	-0.7	-0.1	-0.1	0.4	-0.6	-0.2	0.2	-0.5	-0.2
Mood swings	0.5	0.9	2.7	1.6	0.6	0.8	1.0	0.1	-0.9	-1.3	-0.5	0.6
Loneliness, isolation	0.8	1.2	4.0	2.0	1.1	1.2	1.3	0.8	-0.6	-0.9	0.0	0.5
Long-standing illness, disability or infirmity	0.6	0.9	4.0	-0.9	0.2	0.2	1.4	-0.1	-0.6	-2.0	-0.8	0.3
Ever had bowel cancer screening	0.6	0.7	1.6	-0.8	-0.9	-0.8	0.6	-1.0	0.9	0.6	-1.3	-0.2
Diabetes diagnosed by doctor	0.2	0.4	1.8	0.0	0.5	0.2	-0.8	0.3	-0.1	-1.3	0.5	0.3
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	6.4	-1.3	-1.7	-1.6	-0.7	-1.4	2.5	1.6	0.3	0.6
Friendships satisfaction	0.9	1.1	3.8	0.5	1.3	2.0	0.4	0.3	-1.2	-1.4	-0.2	0.2
Qualifications: nursing, teaching	0.6	1.0	3.4	-0.4	-0.6	-0.5	-0.7	-0.8	1.3	1.3	1.9	0.7
Commuting to job workplace: Walk	0.5	0.5	2.5	0.3	-0.3	-0.1	-0.2	0.2	-1.0	-0.8	1.6	-0.3
Eye problems/disorders: Cataract	0.5	0.6	1.6	0.1	-0.9	-1.3	-1.0	-0.6	0.6	0.6	-0.0	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	-0.2	0.8	0.5	-0.4	-0.5	0.2	0.1	0.7	-0.7
Medication for cholesterol	4.5	6.8	14.7	-1.7	-3.4	-3.8	-1.3	-3.2	3.0	3.3	-0.6	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.3	-0.2	-1.4	-1.4	-1.5	-1.2	0.9	-0.0	-0.0	-0.6
Back pain experienced in last month	0.4	0.6	3.9	0.3	0.2	0.2	2.0	-0.7	-0.3	-0.5	0.3	0.6
Mineral and other dietary supplements	1.2	1.6	6.2	-1.2	-0.5	-0.2	2.2	-0.9	0.3	0.8	0.8	2.5
Breast cancer (self-reported)	0.4	0.5	1.8	0.2	0.6	0.7	-1.3	0.1	-0.0	-0.2	0.4	-1.3
Asthma (self-reported)	0.5	1.0	4.2	-0.4	0.6	1.0	0.9	0.2	-0.6	-1.4	-2.0	-0.5
Osteoporosis (self-reported)	1.3	1.6	4.2	-1.5	-0.4	-0.6	0.3	-1.0	2.0	0.9	1.6	1.8
Osteoarthritis (self-reported)	1.6	2.0	3.8	-1.9	-1.9	-1.9	-1.0	-1.8	1.3	0.7	0.4	0.4
Medication: Aspirin	1.6	2.1	4.0	1.4	1.5	1.6	0.5	1.6	-1.6	-2.0	-1.0	-1.1
Medication: Gliclazide	0.4	0.5	1.6	-0.1	0.6	0.0	-1.3	0.2	-0.7	-0.8	-0.0	-1.0
Illnesses of father: None of the above (group 1)	1.2	1.4	4.1	-0.1	1.8	1.3	-0.8	0.9	-2.0	-1.2	0.2	-1.1
Smoking status: Current	0.6	0.9	2.8	0.8	-1.6	-1.7	-0.1	-0.8	0.0	-0.4	-1.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.4	11.2	0.0	3.3	3.2	1.2	2.8	-3.4	-3.1	1.9	1.8
Whole body water mass	0.1	0.7	1.4	0.5	1.1	0.6	-0.9	0.2	-1.2	-1.0	1.0	-0.7
Leg predicted mass (right)	0.1	0.7	3.5	0.5	0.5	0.1	-1.9	-0.1	-0.6	-0.4	1.0	-0.9
Arm fat mass (left)	0.4	1.5	3.0	-0.5	-1.4	-1.4	-1.7	-1.3	1.4	1.4	-0.0	-0.7
Number of self-reported non-cancer illnesses	0.5	0.9	2.2	-0.2	1.5	1.0	0.1	1.1	-1.0	-1.3	0.7	-0.7
Average weekly champagne plus white wine intake	0.7	0.9	2.3	0.1	1.4	1.5	-0.2	1.2	-1.3	-0.6	-0.4	-0.8
Miserableness	0.7	1.2	4.3	2.1	0.9	0.9	1.5	0.7	-0.2	-0.7	0.7	0.8
Guilty feelings	0.4	0.6	2.5	0.6	-0.4	-0.4	-0.5	-1.0	1.6	0.4	0.2	0.6
Wears glasses or contact lenses	0.7	0.8	1.8	-0.3	0.9	0.7	-0.7	1.3	-1.2	-0.2	-0.5	-1.3
Ever taken oral contraceptive pill	1.3	1.5	4.9	-1.3	-0.3	-0.4	1.1	-1.4	1.4	0.2	1.1	2.2
Hearing aid user	1.1	1.2	5.7	0.3	0.5	0.7	2.4	0.7	1.1	0.5	-0.3	1.6
Mother’s age at death	0.9	1.1	3.9	0.2	-0.6	-0.9	-1.6	0.4	-0.6	-0.2	-1.4	-2.0
Financial situation satisfaction	0.4	0.4	1.1	-0.7	-1.1	-0.9	-0.1	-0.9	0.1	0.7	-0.1	0.3
Tinnitus: Yes, now most or all of the time	2.0	2.3	7.2	-0.8	-2.3	-1.8	1.1	-1.7	0.5	0.4	-2.7	0.6
Commuting to job workplace: Public transport	0.1	0.2	0.6	-0.1	-0.8	-0.3	0.4	-0.0	0.4	0.2	-0.7	0.1
Eye problems/disorders: Glaucoma	0.8	0.9	5.6	0.3	0.2	-0.4	-2.4	-0.6	0.3	0.5	0.0	-1.4
Medication: Blood pressure	4.6	8.7	17.2	1.8	4.0	4.2	0.9	3.9	-3.6	-3.5	0.5	-0.2
Pain type(s) experienced in last month: Hip pain	0.9	1.1	4.9	0.2	0.9	0.9	0.4	-0.5	0.0	-1.6	2.2	0.8
Supplements: Fish oil (including cod liver oil)	1.4	1.8	6.9	0.8	0.3	-0.2	-2.4	0.7	-0.5	-1.2	-1.0	-2.6
High cholesterol (Self-reported)	0.3	0.6	2.4	-0.2	-0.5	-0.4	0.4	0.4	1.3	1.6	0.8	0.3
Medication: Bendroflumethiazide	2.7	4.1	10.6	1.2	3.3	3.1	0.3	2.6	-1.6	-1.9	1.2	0.4
Medication: Paracetamol	0.6	0.9	1.7	-0.8	-1.1	-1.2	-0.6	-1.2	1.3	1.1	0.3	0.4
Medication: Lisinopril	0.7	0.9	1.9	1.0	1.3	1.2	0.2	0.9	-0.9	-1.4	-0.5	-0.5
Medication: Atorvastatin	0.4	0.4	1.3	0.6	0.4	0.3	0.5	0.8	-1.1	0.5	0.1	-0.9
Illnesses of father: High blood pressure	1.0	1.2	5.1	-0.4	-0.2	0.1	2.2	0.2	0.6	0.8	0.7	2.0
Alcohol drinker status: Never	2.9	3.5	6.8	-0.4	-2.6	-2.6	0.9	-2.1	1.9	2.1	-1.5	1.4
Ever smoked	0.4	0.6	2.4	-0.8	-0.6	-0.9	-1.6	-0.8	0.4	0.3	0.4	-0.5
Basal metabolic rate	0.1	0.5	1.5	0.1	0.6	0.2	-1.2	-0.1	-0.7	-0.5	0.9	-0.9
Leg fat percentage (left)	0.7	2.5	4.5	-1.2	-2.1	-2.1	-0.7	-1.8	2.0	2.0	-0.3	0.3
Arm fat-free mass (left)	0.1	0.5	1.1	0.5	0.8	0.4	-0.5	0.2	-1.0	-1.1	0.7	-0.5
Number of operations (self-reported)	0.1	0.2	0.6	0.5	-0.6	-0.3	0.4	-0.8	0.5	-0.0	-0.0	-0.0
Average weekly beer plus cider intake	1.0	1.4	6.4	2.5	0.0	0.3	1.8	0.3	-0.1	-0.5	-1.1	1.2
Irritability	0.3	0.6	1.7	0.6	-0.3	-0.3	-0.8	-1.1	0.2	-0.6	-0.8	-1.3
Risk taking	1.0	1.5	3.3	0.5	-1.4	-1.8	0.4	-1.4	1.7	1.2	-0.5	1.0
Ever had prostate specific antigen (PSA) test	0.9	1.0	3.4	1.1	0.6	0.8	1.8	0.6	-0.9	-0.7	-0.2	1.4
Fractured/broken bones in last 5 years	2.9	3.7	6.8	-1.3	-2.4	-2.6	-1.5	-2.5	2.1	2.4	-0.2	-0.4
Age started oral contraceptive pill	1.2	1.5	3.9	-0.3	2.0	1.8	-0.4	0.8	-0.5	-1.9	1.1	-0.2
Diastolic blood pressure, automated reading	0.6	1.8	3.1	0.4	1.5	1.7	1.4	1.7	-1.6	-0.3	1.8	0.8
Ever depressed for a whole week	0.8	1.0	3.3	1.2	-1.0	-0.7	1.8	-0.6	0.1	0.5	-1.2	0.5
Unable to work because of sickness or disability	0.4	0.5	1.3	1.1	0.8	0.6	1.0	0.1	-0.1	-0.6	0.1	0.7
Commuting to job workplace: Cycle	0.2	0.3	1.0	-0.6	0.0	0.4	-0.7	-0.4	0.2	-0.6	1.0	0.0
Myopia	0.5	0.8	2.6	0.2	-1.6	-1.3	0.2	-1.0	0.6	0.9	-0.6	0.3
Vascular/heart problems diagnosed by doctor	3.9	10.5	21.3	-1.7	-4.5	-4.6	-2.2	-3.9	3.7	3.8	-1.5	-0.8
Cholesterol lowering medication	0.8	1.2	3.5	1.4	1.6	1.9	0.8	1.0	0.1	-0.3	0.8	0.5
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	4.5	-2.0	-1.3	-1.6	-0.8	-2.1	1.9	1.6	0.4	0.1
Pain experienced in last month	0.1	0.2	0.4	-0.4	0.2	0.5	-0.1	0.5	0.0	0.6	-0.7	0.3
Supplements: Calcium	0.2	0.2	0.7	0.0	-0.1	-0.0	-0.9	-0.6	0.3	-0.1	-0.0	-0.6
Basal cell carcinoma (self-reported)	0.6	0.8	3.5	0.9	-0.2	-0.4	-1.3	0.3	-0.1	-0.2	1.9	-0.7
Heart attack/myocardial infarction (self-reported)	0.8	1.1	5.1	0.6	-0.5	-0.6	-1.1	-0.7	0.0	-0.7	-2.3	-1.3
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	4.4	-0.7	2.1	1.8	-0.0	0.7	-1.5	-1.7	1.4	-0.4
Heart disease (siblings)	1.2	1.5	3.8	-0.9	-1.0	-1.1	0.6	-1.8	2.0	1.4	0.2	1.1
Alcohol drinker status: Previous	0.5	0.5	1.0	0.2	-0.8	-0.7	0.9	-1.0	0.9	-0.0	-0.4	0.9
Pack years of smoking	0.6	0.9	2.0	0.5	1.4	1.3	0.8	0.8	-0.4	-0.9	1.1	0.4
Impedance of whole body	0.7	3.7	6.2	-1.9	-2.5	-2.3	-1.2	-1.8	2.5	1.9	-1.6	-0.7
Leg fat mass (left)	0.5	1.9	3.6	-1.0	-1.8	-1.9	-1.1	-1.7	1.5	1.7	-0.2	-0.1
Arm predicted mass (left)	0.1	0.4	1.0	0.4	0.9	0.6	-0.3	0.2	-0.9	-1.0	0.5	-0.6