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chr15:90,712,555-92,187,978

Best TWAS P=1.13e-38 · Best GWAS P=8.67e-29 conditioned to 0.591

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FURIN	0.12	0.14	lasso	2	0.13	1.2e-15	-7.3	7.3	3.7e-13	0.82	0.99	0.01	TRUE
2	GTEx	Adipose Visceral Omentum	FES	0.21	0.09	lasso	5	0.05	1.3e-03	11.1	-10.9	1.5e-27	-0.70	0.01	0.98	FALSE
3	GTEx	Artery Tibial	FES	0.16	0.04	lasso	5	0.05	4.8e-05	10.1	-11.3	1.0e-29	-0.73	0.02	0.98	FALSE
4	GTEx	Breast Mammary Tissue (Male)	RCCD1	0.33	-0.01	enet	28	0.07	1.3e-02	11.1	5.5	3.9e-08	0.45	0.03	0.50	FALSE
5	GTEx	Cells Transformed fibroblasts	FES	0.28	0.17	enet	21	0.20	2.8e-15	11.1	-11.9	9.6e-33	-0.90	0.01	0.99	FALSE
6	GTEx	Lung	FES	0.24	0.07	lasso	6	0.05	5.1e-05	10.1	-11.8	5.3e-32	-0.79	0.01	0.98	FALSE
7	GTEx	Skin Sun Exposed Lower leg	FES	0.09	0.04	lasso	5	0.04	1.4e-04	11.1	-9.6	8.9e-22	-0.66	0.01	0.96	FALSE
8	GTEx	Thyroid	FES	0.33	0.19	lasso	6	0.18	4.3e-14	10.6	-10.6	2.3e-26	-0.70	0.03	0.97	TRUE
9	METSIM	Adipose	FES	0.08	0.06	lasso	3	0.05	6.8e-08	10.1	-10.4	3.1e-25	-0.63	0.26	0.74	FALSE
10	YFS	Blood	FES	0.31	0.11	enet	77	0.22	1.2e-68	11.1	-10.4	1.9e-25	-0.68	0.00	1.00	FALSE
11	YFS	Blood	FURIN	0.11	0.03	enet	37	0.06	8.3e-19	-7.3	-7.8	6.1e-15	-0.67	0.13	0.87	FALSE
12	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FES	0.06	0.05	blup	46	0.06	1.9e-05	11.0	-10.2	1.7e-24	-0.83	0.00	0.99	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	FES	0.06	0.05	blup	46	0.07	7.4e-14	11.1	-13.0	1.1e-38	-0.89	0.00	1.00	TRUE
14	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FES	0.06	0.02	blup	46	0.02	2.4e-02	11.1	-11.0	4.7e-28	-0.77	0.00	0.87	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	FES	0.08	0.07	blup	46	0.06	3.4e-04	10.6	-11.3	2.2e-29	-0.91	0.01	0.96	FALSE
16	The Cancer Genome Atlas	Glioblastoma Multiforme	FES	0.12	0.06	enet	6	0.06	5.7e-03	11.0	-10.5	5.3e-26	-0.94	0.01	0.90	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FES	0.06	0.03	blup	46	0.05	5.6e-06	11.0	-10.5	5.7e-26	-0.81	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FES	0.10	0.07	enet	5	0.05	2.8e-06	11.1	-10.6	1.9e-26	-0.99	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	FES	0.05	0.04	lasso	2	0.04	2.2e-05	11.1	-11.9	6.9e-33	-0.90	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FES	0.08	0.07	enet	7	0.08	4.2e-09	11.1	-11.6	3.1e-31	-0.82	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FES	0.13	0.16	lasso	2	0.14	6.1e-10	11.1	-11.0	3.5e-28	-0.71	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	FES	0.12	0.09	lasso	5	0.08	4.1e-09	11.1	-12.2	2.7e-34	-0.80	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Stomach Adenocarcinoma	FES	0.04	0.01	blup	46	0.02	1.7e-02	11.0	-11.0	6.1e-28	-0.78	0.01	0.61	FALSE
24	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FES	0.32	0.26	lasso	2	0.25	2.0e-09	11.1	-11.2	4.0e-29	-0.72	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	FES	0.30	0.30	lasso	7	0.32	1.3e-31	11.1	-12.2	2.7e-34	-0.84	0.00	1.00	FALSE