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chr16:89,013,848-90,172,696

Best TWAS P=6.92e-13 · Best GWAS P=9e-13 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHMP1A	0.04	0.03	enet	9	0.05	7.5e-10	-6.6	7.2	6.9e-13	-0.87	0.01	0.99	TRUE
41	GTEx	Thyroid	SPATA33	0.20	0.18	lasso	6	0.19	2.7e-14	-6.6	-6.3	3.4e-10	0.94	0.01	0.99	TRUE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DPEP1	0.04	0.01	enet	6	0.03	1.0e-04	-6.2	-5.7	1.0e-08	0.66	0.02	0.77	TRUE
15	GTEx	Colon Transverse	SPATA33	0.23	0.16	enet	14	0.19	2.2e-09	-6.6	-5.6	1.6e-08	0.87	0.01	0.99	TRUE
29	GTEx	Prostate	SPATA33	0.35	0.01	lasso	5	0.05	2.8e-02	-6.8	-5.4	5.9e-08	0.75	0.02	0.82	TRUE
40	GTEx	Thyroid	DEF8	0.18	0.04	enet	16	0.13	7.8e-10	-1.7	5.2	2.0e-07	-0.34	0.45	0.11	TRUE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHMP1A	0.07	0.03	blup	37	0.03	1.3e-04	4.6	5.1	2.7e-07	-0.79	0.00	0.99	TRUE
35	GTEx	Spleen	SPATA33	0.20	0.00	lasso	5	0.01	1.5e-01	6.2	5.1	2.8e-07	-0.61	0.03	0.68	TRUE
42	GTEx	Thyroid	CDK10	0.36	0.16	lasso	9	0.21	9.7e-16	-6.6	-7.2	7.0e-13	0.89	0.02	0.98	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHMP1A	0.04	0.05	enet	3	0.05	2.1e-06	-7.1	7.1	1.8e-12	-0.97	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	CHMP1A	0.05	0.03	blup	38	0.04	1.6e-03	-7.1	7.0	2.0e-12	-0.94	0.01	0.96	FALSE
17	GTEx	Esophagus Mucosa	SPATA33	0.26	0.17	lasso	6	0.16	9.1e-11	-6.6	-6.9	4.7e-12	0.96	0.01	0.99	FALSE
21	GTEx	Lung	SPATA33	0.15	0.11	enet	9	0.13	5.6e-10	6.0	-6.9	7.2e-12	0.91	0.03	0.97	FALSE
9	GTEx	Artery Tibial	SPATA33	0.18	0.12	lasso	3	0.10	1.6e-08	-6.6	-6.8	7.7e-12	0.95	0.02	0.98	FALSE
23	GTEx	Muscle Skeletal	SPATA33	0.10	0.04	enet	5	0.05	8.3e-06	6.2	-6.8	9.1e-12	0.90	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	C16orf55	0.03	0.05	enet	6	0.05	3.5e-06	-6.4	6.8	1.2e-11	-0.96	0.01	0.99	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	SPATA33	0.12	0.09	lasso	4	0.10	3.4e-06	-6.6	-6.8	1.4e-11	0.97	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	SPATA33	0.17	0.12	lasso	6	0.12	5.6e-10	-6.6	-6.7	2.4e-11	0.96	0.01	0.99	FALSE
7	GTEx	Artery Aorta	SPATA33	0.19	0.06	enet	15	0.12	3.7e-07	-6.6	-6.5	8.6e-11	0.86	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	DPEP1	0.06	0.01	blup	44	0.02	1.6e-03	5.8	6.5	9.7e-11	-0.64	0.07	0.64	FALSE
27	GTEx	Pituitary	SPATA33	0.29	0.18	lasso	6	0.15	1.6e-04	6.2	-6.4	1.2e-10	0.69	0.03	0.76	FALSE
26	GTEx	Pancreas	SPATA33	0.13	0.14	lasso	10	0.11	2.2e-05	-6.8	-6.4	1.5e-10	0.98	0.01	0.99	FALSE
33	GTEx	Skin Sun Exposed Lower leg	CHMP1A	0.36	0.11	enet	29	0.19	1.5e-15	4.6	6.4	1.5e-10	-0.79	0.05	0.95	FALSE
43	GTEx	Whole Blood	SPATA33	0.05	0.02	enet	9	0.02	6.3e-03	-6.2	-6.4	1.5e-10	0.87	0.04	0.96	FALSE
5	GTEx	Adipose Visceral Omentum	SPATA33	0.16	0.10	lasso	3	0.07	1.2e-04	-6.8	-6.4	1.6e-10	0.97	0.01	0.99	FALSE
18	GTEx	Esophagus Muscularis	SPATA33	0.25	0.18	lasso	11	0.17	1.7e-10	-6.8	-6.4	1.6e-10	0.95	0.00	1.00	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHMP1A	0.04	0.04	lasso	4	0.05	6.3e-06	-7.1	6.4	1.6e-10	-0.94	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CHMP1A	0.10	0.07	lasso	2	0.09	6.7e-08	4.6	6.4	1.9e-10	-0.88	0.01	0.99	FALSE
10	GTEx	Breast Mammary Tissue	CDK10	0.45	0.22	lasso	6	0.23	7.1e-12	6.0	-6.3	2.5e-10	0.80	0.30	0.70	FALSE
36	GTEx	Spleen	CDK10	0.36	0.22	enet	6	0.06	1.3e-02	6.2	-6.3	3.4e-10	0.75	0.10	0.60	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf55	0.04	0.01	blup	36	0.02	1.7e-03	-6.6	-6.3	3.7e-10	0.92	0.01	0.74	FALSE
19	GTEx	Heart Atrial Appendage	CDK10	0.26	0.07	lasso	3	0.13	1.4e-06	-6.2	-6.2	4.5e-10	0.72	0.07	0.85	FALSE
12	GTEx	Breast Mammary Tissue (Female)	CDK10	0.07	0.02	lasso	2	0.00	4.6e-01	6.0	-6.2	5.2e-10	0.79	0.04	0.41	FALSE
28	GTEx	Pituitary	CDK10	0.41	0.22	enet	17	0.15	1.2e-04	6.2	-6.2	6.2e-10	0.68	0.04	0.88	FALSE
22	GTEx	Lung	CDK10	0.25	0.18	lasso	7	0.19	1.0e-14	6.2	-6.1	8.2e-10	0.72	0.20	0.80	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C16orf55	0.06	0.02	lasso	3	0.02	6.2e-04	6.2	-6.1	8.8e-10	0.76	0.08	0.92	FALSE
54	The Cancer Genome Atlas	Stomach Adenocarcinoma	C16orf55	0.09	0.04	blup	36	0.04	7.1e-04	6.2	-6.1	9.2e-10	0.73	0.12	0.71	FALSE
20	GTEx	Heart Left Ventricle	SPATA33	0.07	0.02	enet	6	0.03	6.7e-03	-6.9	-6.1	9.6e-10	0.93	0.00	0.99	FALSE
6	GTEx	Artery Aorta	SPATA2L	0.08	0.00	enet	10	0.05	6.6e-04	3.3	6.1	1.0e-09	-0.62	0.04	0.77	FALSE
24	GTEx	Nerve Tibial	CDK10	0.42	0.28	enet	16	0.35	1.2e-25	6.0	-6.1	1.2e-09	0.72	0.36	0.64	FALSE
14	GTEx	Cells Transformed fibroblasts	AC092143.1	0.07	0.00	lasso	6	0.00	5.0e-01	-6.6	-6.0	1.5e-09	0.90	0.04	0.68	FALSE
16	GTEx	Colon Transverse	CDK10	0.34	0.15	lasso	5	0.16	4.2e-08	6.2	-5.9	3.4e-09	0.64	0.22	0.76	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	CDK10	0.08	0.04	lasso	2	0.03	1.1e-04	6.0	-5.9	3.8e-09	0.73	0.18	0.32	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	CDK10	0.06	0.04	blup	43	0.04	8.9e-05	6.0	-5.9	4.2e-09	0.51	0.33	0.39	FALSE
25	GTEx	Ovary	CDK10	0.45	0.11	lasso	8	0.25	6.8e-07	2.3	-5.8	7.8e-09	0.68	0.04	0.85	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	CHMP1A	0.25	0.01	enet	21	0.08	5.3e-05	4.6	5.7	1.2e-08	-0.50	0.10	0.82	FALSE
37	GTEx	Stomach	CDK10	0.35	0.12	enet	12	0.22	6.4e-11	2.3	-5.7	1.4e-08	0.53	0.77	0.14	FALSE
39	GTEx	Testis	VPS9D1-AS1	0.14	0.03	lasso	6	0.06	1.7e-03	-3.6	5.6	1.6e-08	-0.57	0.12	0.36	FALSE
38	GTEx	Testis	CDK10	0.28	0.14	lasso	6	0.24	4.1e-11	6.2	-5.6	1.8e-08	0.64	0.09	0.90	FALSE
2	GTEx	Adipose Subcutaneous	DEF8	0.11	0.02	enet	16	0.06	1.3e-05	5.8	5.5	3.4e-08	-0.43	0.18	0.45	FALSE
13	GTEx	Cells Transformed fibroblasts	SPATA33	0.11	0.05	enet	22	0.05	1.1e-04	-6.6	-5.5	3.4e-08	0.84	0.01	0.99	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	CDK10	0.27	0.19	lasso	9	0.28	1.2e-15	6.0	-5.5	4.9e-08	0.65	0.35	0.65	FALSE
8	GTEx	Artery Aorta	CDK10	0.33	0.07	enet	27	0.18	2.7e-10	2.3	-5.3	9.9e-08	0.50	0.51	0.48	FALSE
34	GTEx	Skin Sun Exposed Lower leg	CDK10	0.30	0.18	enet	18	0.29	3.0e-24	2.3	-5.2	1.9e-07	0.57	0.92	0.08	FALSE
4	GTEx	Adipose Subcutaneous	CDK10	0.37	0.20	enet	50	0.26	4.0e-21	6.0	-5.2	2.3e-07	0.60	0.41	0.59	FALSE
11	GTEx	Breast Mammary Tissue (Male)	CDK10	0.12	0.08	enet	6	0.01	2.2e-01	-5.3	-5.2	2.5e-07	0.76	0.04	0.32	FALSE