Hub : Genes

C16orf55

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0560 0.0240 1.4e-03 0.020 0.014 0.023 0.011 0.024 1.6e-03 6.0e-03 6.7e-04 0.015 6.2e-04
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0728 0.0334 2.7e-03 0.050 0.020 0.045 NA 0.043 2.3e-06 2.2e-03 8.2e-06 NA 1.3e-05
3 TCGA Brain Lower Grade Glioma 0.0344 0.0169 1.8e-05 0.046 0.044 0.048 NA 0.047 5.8e-06 8.3e-06 3.5e-06 NA 4.0e-06
4 TCGA Stomach Adenocarcinoma 0.0880 0.0440 6.6e-05 0.037 0.040 0.026 NA 0.026 9.8e-04 7.1e-04 5.5e-03 NA 5.3e-03
5 TCGA Thyroid Carcinoma 0.0400 0.0240 2.4e-03 0.010 0.025 0.004 NA 0.003 3.0e-02 1.7e-03 1.1e-01 NA 1.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 8.3 13.1 16.9 3.7 2.4 -3.7 4.1 4.0
Bipolar Disorder or Schizophrenia 6.2 15.1 21.0 3.8 1.6 -4.6 4.2 4.4
Depressed Affect (Nagel 2018) 0.1 0.2 0.5 -0.1 0.6 -0.2 0.7 0.3
Depression (Nagel 2018) 1.3 1.9 3.5 -1.9 -1.5 1.4 -1.0 -1.1
Intelligence (Savage-Jansen 2018) 0.7 2.1 5.9 -0.3 -0.1 2.0 -0.7 -2.4
Neuroticism (Nagel 2018) 1.3 3.0 6.4 -2.5 -1.2 1.5 -1.9 -1.3
Schizophrenia (2018) 2.2 4.5 8.5 1.9 0.1 -2.9 2.0 2.5
Schizophrenia vs Biploar Disorder 1.2 1.6 3.5 -1.9 -0.9 0.5 -1.9 -0.4
Worry (Nagel 2018) 0.8 1.8 3.1 -1.8 -1.5 0.8 -1.5 -0.8
Alzheimer’s Disease (in mother) 4.0 4.7 8.0 2.8 0.7 -2.1 2.6 2.0
Alzheimer’s Disease (in father) 0.7 0.7 1.4 1.2 0.4 -0.4 1.1 0.8
Alzheimer’s Disease (including proxy) 3.0 4.3 7.6 2.8 0.0 -1.9 2.6 1.9
Crohns Disease (2017) 0.1 0.3 0.7 -0.8 0.4 0.2 -0.6 -0.1
Irritable Bowel Disease (IBD) 0.1 0.2 0.8 -0.4 0.9 0.2 -0.3 -0.0
Ulcerative Colitis (UC) 0.1 0.2 0.7 0.3 0.9 -0.1 0.1 0.2
Major Depression (MDD) 1.0 1.2 2.4 -1.3 -1.3 0.4 -1.5 -0.3
Reaction Time 0.0 0.1 0.2 -0.3 -0.5 -0.2 0.0 -0.1
Verbal and Numeric Reasoning (VNR) 1.5 3.7 7.2 -1.1 -0.7 2.6 -1.6 -2.7
Breast Cancer 0.9 2.3 4.4 2.1 -1.5 -1.3 1.7 0.1
Ovarian Cancer 0.4 0.6 1.6 1.3 -0.2 -0.7 0.8 0.5
Prostate Cancer 0.9 1.2 2.0 -1.2 -1.4 0.9 -1.3 -0.5
Age at First Birth 1.9 2.8 3.8 -1.1 -1.6 1.8 -1.7 -1.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 2.6 3.6 7.7 -2.2 -2.2 0.4 -2.8 -0.8
Coronary Artery Disease (CAD) 0.2 0.2 1.1 1.1 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.5 0.8 3.8 0.1 1.9 0.1 0.4 0.1
Mean Putamen Volume 0.9 1.0 2.3 -0.8 -1.5 -1.0 -0.8 0.8
Fasting Glucose 0.7 0.8 1.8 0.5 1.3 -0.8 0.6 1.0
HbA1C 4.7 5.2 9.7 2.3 0.1 -3.1 2.3 2.4
HDL Cholesterol 0.4 0.6 1.0 0.1 -1.0 1.0 -0.6 -0.8
LDL Cholesterol 0.3 0.6 2.1 -0.3 1.5 -0.2 0.1 0.7
Lupus 0.2 0.4 0.9 0.2 0.1 -0.9 0.2 0.9
Neuroticism (2016) 1.3 1.8 3.0 -1.7 0.4 1.6 -1.4 -1.1
Primary Biliary Cirrhosis 0.3 0.4 0.7 -0.7 0.4 -0.6 -0.6 0.8
Rheumatoid Arthritis 0.3 0.4 1.4 -0.2 0.1 -0.8 0.3 1.2
Schizophrenia (2014) 5.2 11.6 20.1 2.7 1.8 -4.5 2.8 4.5
Triglycerides 0.9 1.5 3.0 -0.5 1.4 -1.4 0.3 1.7
Type 2 Diabetes (T2D) (2012) 1.8 2.1 3.9 1.0 2.0 -1.1 1.1 1.8
Ulcerative Colitis 0.3 0.4 1.5 -0.0 1.2 0.4 0.4 -0.2
Blood Eosinophil Count 0.0 0.3 0.5 0.6 0.2 -0.5 0.7 0.4
Blood Platelet Count 0.3 4.0 7.4 -2.1 0.1 2.7 -1.4 -2.5
Blood Red Count 1.3 12.5 20.5 4.5 -1.4 -4.2 3.6 3.1
Blood White Count 1.1 8.3 15.7 4.0 0.8 -3.0 3.1 2.5
Heel T-Score 1.0 7.7 33.4 1.4 5.8 0.9 1.6 -0.3
BMI 0.7 3.8 9.7 1.0 -0.2 -2.9 0.4 3.1
Height 2.6 50.0 193.2 4.2 13.9 1.5 6.1 -0.1
Waist Hip Ratio (WHR) 0.9 4.2 6.2 2.3 2.5 -1.1 2.4 1.6
Systolic Blood Pressure 2.7 13.8 20.1 -4.3 -2.0 4.0 -4.5 -3.2
Smoking Status 1.7 4.0 6.1 1.7 2.5 -1.6 2.3 1.8
Allergy or Eczema 0.3 0.8 2.1 1.0 0.4 -0.4 1.4 0.9
Cardiovascular Disease 9.8 32.2 50.6 -6.3 -0.7 7.1 -5.9 -5.9
Hypothyroidism (self reported) 0.7 1.6 3.3 1.3 1.8 -0.6 1.2 1.2
Respiratory disease 3.2 7.1 14.9 2.0 3.9 -1.4 3.0 2.4
Type 2 Diabetes (T2D) (2018) 1.5 2.9 4.5 1.7 1.1 -1.9 1.5 2.1
Lung FEV1/FVC ratio 0.1 0.3 0.7 -0.5 -0.3 0.5 -0.8 -0.6
Lung FVC 0.7 3.7 6.2 0.2 2.5 2.4 0.4 -2.4
Neuroticism 1.1 2.7 6.3 -2.1 -2.5 0.2 -1.6 -0.6
Chronotype (morning person) 0.0 0.0 0.1 -0.2 -0.1 0.0 -0.3 -0.1
Hair Pigment 526.1 15003.3 30276.0 -124.0 -174.0 60.5 -136.0 -84.9
Tanning 548.3 6693.4 10609.0 85.1 103.0 -47.8 95.9 64.3
Hand grip strength (left) 2.0 5.2 10.5 -0.6 3.2 3.0 0.3 -2.6
Number of treatments/medications taken 0.3 0.5 1.0 -1.0 -0.9 0.4 -0.7 -0.1
Average weekly spirits intake 1.9 2.3 4.1 -1.2 -0.8 2.0 -1.6 -1.7
Sensitivity / hurt feelings 1.2 2.0 3.9 -1.9 -0.5 1.3 -2.0 -0.8
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.0 -1.0 0.2 0.7 -0.2 -0.4
Hearing difficulty/problems: Yes 0.7 1.1 3.2 0.2 1.8 0.1 1.4 0.5
Relative age of first facial hair 8.9 18.3 46.8 -3.7 -6.8 1.1 -4.5 -3.0
Other serious medical condition/disability diagnosed by doctor 4.0 5.2 10.8 2.1 -0.7 -3.3 1.5 2.9
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.0 -0.4 -1.0 0.2 -0.0 -0.3
Ever had hysterectomy (womb removed) 0.8 0.9 1.9 0.8 1.0 -0.7 1.4 0.7
Systolic blood pressure, automated reading 0.3 0.9 1.4 -0.8 -1.2 0.9 -1.0 -0.8
Eye problems/disorders: Diabetes related eye disease 2.5 2.7 4.7 1.9 1.1 -1.4 2.2 1.5
Angina 0.7 0.9 2.0 -0.9 -1.1 0.3 -1.4 -0.4
Medication for hormone replacement therapy 0.5 0.6 1.7 -1.3 0.2 0.6 -0.9 -0.2
Vitamin and mineral supplements 0.3 0.3 0.9 -0.1 0.6 0.7 0.0 -1.0
Supplements: Zinc 0.3 0.3 1.2 -0.1 1.1 0.6 0.1 0.3
Medication: Co-codamol 0.1 0.1 0.5 -0.1 0.7 0.3 -0.0 0.1
Medication: Metformin 0.1 0.2 0.6 -0.2 0.8 0.1 -0.3 0.1
Diabetes (father) 1.8 2.3 3.6 1.3 1.9 -1.6 0.8 1.7
Diabetes (mother) 3.1 3.9 8.3 1.1 1.3 -2.6 1.3 2.9
Severe depression (siblings) 6.9 7.7 11.5 2.6 1.6 -3.0 2.9 3.4
Pack years adult smoking proportion 1.4 2.1 4.3 0.5 1.9 -1.4 0.7 2.1
Impedance of leg (right) 1.6 7.6 21.8 2.2 4.7 -0.0 3.2 0.9
Leg fat-free mass (left) 0.3 1.7 8.6 -0.1 2.9 0.3 0.1 0.2
Trunk fat percentage 3.0 11.9 17.8 2.9 4.2 -3.3 3.0 3.6
Hand grip strength (right) 1.1 2.9 4.8 0.0 2.2 2.1 0.5 -2.2
Townsend deprivation index at recruitment 0.4 0.5 1.1 -0.3 -0.5 -1.0 0.3 1.0
Current tobacco smoking 1.5 2.5 8.6 0.8 2.9 -0.3 1.5 1.0
Average weekly fortified wine intake 1.1 1.3 1.8 -0.8 -1.1 1.3 -1.1 -1.2
Maternal smoking around birth 1.4 2.1 6.2 0.6 2.5 -0.8 1.0 1.4
Fed-up feelings 0.3 0.6 2.2 -0.4 -1.5 -0.3 -0.7 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.3 -0.6 -0.1 0.4 0.3 -0.5
Relative age voice broke 3.9 6.0 22.7 -1.7 -4.8 -0.5 -1.9 -0.8
Taking other prescription medications 3.2 4.9 9.6 1.8 1.1 -2.9 1.4 3.1
Age when periods started (menarche) 0.1 0.1 0.6 0.1 -0.7 0.0 0.0 -0.3
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 -0.4 -0.4 -0.2 0.2 0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.6 8.7 1.5 3.0 -0.2 1.2 0.7
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 2.0 -1.4 0.3 1.0 -1.2 -0.6
Qualifications: CSEs or equivalent 0.3 0.4 0.6 -0.6 -0.5 -0.7 -0.7 0.7
Serious illness, injury or assault to yourself 0.9 1.1 2.2 1.5 -0.8 -0.8 1.2 0.8
High blood pressure 11.7 32.7 46.0 -6.1 -1.8 6.8 -6.1 -6.3
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.5 0.5 0.2 0.2 0.7 0.4
Multivitamins +/- minerals 0.2 0.2 0.8 0.0 0.9 0.4 0.2 0.3
Stomach or abdominal pain in last month 5.4 6.8 10.4 2.7 1.3 -3.2 2.9 2.4
Supplements: Glucosamine 0.3 0.3 1.1 -0.1 -0.4 -0.6 -0.0 1.0
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 1.5 1.0 1.0 -1.2 0.9 1.1
Medication: Atenolol 6.1 7.6 11.1 -2.3 -2.5 3.0 -2.5 -3.3
Medication: Levothyroxine sodium 1.4 2.4 3.3 1.6 1.5 -1.5 1.3 1.8
Sitting height 0.8 5.9 22.8 1.3 4.8 0.7 2.1 0.1
Chronic bronchitis/emphysema (father) 1.0 1.2 1.6 1.0 0.4 -1.2 1.3 1.2
High blood pressure (mother) 6.5 9.2 13.9 -3.1 -0.6 3.7 -2.9 -3.7
Body mass index (BMI) 0.4 1.6 4.0 0.7 0.1 -2.0 0.2 1.9
Impedance of leg (left) 1.4 6.6 18.9 2.1 4.3 0.2 3.0 0.4
Leg predicted mass (left) 0.3 1.7 8.4 -0.0 2.9 0.3 0.1 0.2
Trunk fat mass 2.3 9.7 20.7 2.5 4.5 -2.4 2.7 2.9
Waist circumference 1.4 5.0 11.4 1.6 3.4 -1.6 1.7 2.4
Number of incorrect matches in round 2.2 3.7 6.5 2.5 1.0 -1.5 2.5 1.5
Past tobacco smoking 1.6 2.9 3.8 -1.8 -1.1 1.8 -1.9 -1.8
Alcohol usually taken with meals 0.5 0.8 1.6 -0.8 -1.1 0.7 -1.3 -0.5
Nervous feelings 0.1 0.2 0.7 -0.9 -0.4 -0.1 -0.2 0.0
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 5.4 0.1 -2.3 -1.3 0.8 0.5
Hearing difficulty/problems with background noise 0.3 0.6 1.5 0.2 1.0 -0.1 1.2 0.5
Hair/balding pattern: Pattern 2 0.1 0.2 0.4 0.4 -0.6 -0.2 0.1 -0.6
Had menopause 2.0 2.4 8.8 0.4 -3.0 0.8 0.3 -1.6
Had other major operations 4.9 5.9 9.6 1.9 2.5 -2.1 2.4 3.1
Forced vital capacity (FVC) 1.8 7.0 20.5 -0.3 4.5 3.0 0.7 -2.2
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 8.1 1.3 2.8 0.0 1.2 0.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.4 0.0 -0.4 -0.8 0.2 1.2
Qualifications: None of the above 0.2 0.4 0.8 0.5 -0.2 -0.9 0.6 0.6
Financial difficulties in last 2 years 0.4 0.5 2.3 -0.3 -1.5 -0.2 -0.3 0.4
Mouth/teeth dental problems 0.9 1.4 4.7 -0.3 -0.8 1.2 -0.5 -2.2
Heart attack 0.1 0.1 0.4 0.2 0.6 -0.1 -0.1 0.4
Allergy 0.8 1.9 3.4 -1.0 -1.9 0.8 -1.5 -1.5
Pain all over the body in last month 0.4 0.4 0.6 -0.8 -0.1 -0.5 -0.7 0.8
Diabetes (self-reported) 1.7 2.5 5.0 1.6 0.4 -2.1 0.9 2.2
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.4 -0.4 0.4 -0.3 0.6 0.7
Medication: Ramipril 1.9 2.5 4.2 -1.6 -0.0 1.9 -2.0 -1.4
Medication: Simvastatin 0.3 0.4 0.9 -0.5 -0.1 0.9 -0.7 -0.7
Fluid intelligence score 1.6 3.2 6.0 -1.3 -0.6 2.5 -1.7 -2.3
Illnesses of siblings 0.7 1.0 2.3 1.1 1.5 0.1 1.1 -0.2
Neuroticism score 0.5 1.1 2.4 -1.5 -1.2 -0.0 -1.3 -0.1
Weight 0.8 4.1 16.0 1.1 4.0 -0.5 1.3 1.1
Impedance of arm (right) 1.6 7.6 10.7 2.6 3.2 -1.8 3.3 2.6
Arm fat percentage (right) 1.9 7.3 13.8 2.0 1.8 -3.5 1.9 3.7
Trunk fat-free mass 0.6 3.4 12.2 -0.3 3.5 1.8 0.2 -1.1
Hip circumference 0.7 3.1 12.8 0.8 3.6 -0.2 1.0 1.0
Time employed in main current job 1.5 1.7 2.5 1.1 1.0 -1.6 1.5 1.2
Alcohol intake versus 10 years previously 0.6 0.9 1.4 1.0 0.1 -1.2 1.0 1.0
Father’s age at death 0.7 0.9 1.4 1.2 0.5 -1.2 0.4 1.1
Worrier / anxious feelings 0.0 0.1 0.2 -0.1 0.2 -0.5 -0.2 0.4
Frequency of tiredness / lethargy in last 2 weeks 2.2 3.5 5.4 1.3 1.5 -2.1 1.9 2.3
Falls in the last year 0.3 0.5 0.8 0.6 -0.7 -0.8 0.1 0.9
Hair/balding pattern: Pattern 3 1.6 2.3 3.9 -1.6 -0.9 1.5 -1.4 -2.0
Number of live births 5.4 7.6 14.8 3.6 1.6 -2.1 3.9 1.8
Forced expiratory volume in 1-second (FEV1) 1.6 5.4 11.8 -0.6 3.4 3.0 -0.0 -2.4
Pulse rate 0.7 1.2 2.6 1.6 -0.2 -1.0 1.5 0.5
Happiness 1.6 1.9 5.2 1.6 0.5 -0.9 2.3 0.7
Noisy workplace 0.4 0.5 1.0 -0.6 -1.0 -0.7 -0.5 0.7
Qualifications: A levels/AS levels or equivalent 1.0 2.3 3.0 -1.6 -0.6 1.7 -1.6 -1.7
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 2.7 0.9 1.3 -0.4 1.6 0.6
Mouth/teeth dental problems: Dentures 1.1 1.8 3.5 -0.1 -1.6 -1.9 -0.1 1.6
Asthma 4.2 8.2 18.8 2.4 4.3 -1.4 3.0 2.5
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.0 6.1 0.9 2.5 -0.5 1.4 0.9
Medication: Cholesterol lowering 0.2 0.2 0.5 -0.5 -0.7 0.2 -0.6 -0.4
Depression (self-reported) 2.7 3.2 5.0 1.9 1.0 -1.9 2.2 1.7
Medication: Lansoprazole 2.5 2.8 6.4 1.3 -0.5 -2.5 1.2 2.1
Prospective memory result 0.3 0.3 0.5 -0.7 -0.6 0.6 -0.3 -0.5
Lung cancer (father) 1.3 1.5 2.7 1.2 1.6 -0.7 1.6 0.6
Illnesses of mother 0.7 0.9 1.7 0.8 -0.4 -1.3 0.7 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.1 8.0 -1.2 2.0 2.8 -0.8 -2.5
Pulse wave Arterial Stiffness index 0.2 0.2 0.3 0.5 0.0 -0.5 0.4 0.5
Impedance of arm (left) 1.2 5.6 9.7 2.4 3.1 -1.2 2.9 1.8
Arm fat mass (right) 1.1 4.4 7.0 1.5 2.3 -2.3 1.4 2.6
Trunk predicted mass 0.6 3.3 11.8 -0.2 3.4 1.8 0.2 -1.1
Standing height 2.1 21.3 83.7 1.6 9.2 2.9 3.1 -1.4
Length of working week for main job 0.5 0.6 0.9 -0.5 -0.9 -1.0 -0.7 0.7
Exposure to tobacco smoke at home 0.1 0.2 0.3 -0.1 0.2 -0.4 0.5 0.5
Breastfed as a baby 1.4 1.7 3.6 0.4 -1.9 -1.9 0.0 1.2
Tense / ‘highly strung’ 0.0 0.1 0.1 -0.1 0.4 -0.2 -0.2 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 2.2 3.4 4.3 2.1 1.3 -1.6 2.1 2.1
Hair/balding pattern: Pattern 4 6.8 16.4 22.8 -4.4 -3.4 3.9 -4.8 -3.6
Birth weight of first child 0.6 1.1 3.5 0.2 1.9 1.0 0.5 -0.8
Peak expiratory flow (PEF) 2.4 5.6 10.6 -1.7 2.4 3.3 -1.2 -2.7
Pulse wave reflection index 0.6 0.7 1.3 -1.0 -0.8 0.6 -1.1 -0.4
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 -0.3 -0.2 0.4 0.0 0.2
Loud music exposure frequency 2.3 2.5 3.6 1.7 0.8 -1.5 1.9 1.7
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.7 -0.1 0.8 0.1 -0.2 0.1
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.0 -1.0 0.4 0.7 -0.9 0.1
Blood clot in the leg (DVT) 0.1 0.1 0.4 -0.3 0.2 0.0 -0.3 -0.7
Medication: Paracetamol 0.0 0.1 0.2 -0.1 0.5 0.1 -0.3 0.1
Headache pain in last month 0.2 0.3 0.9 0.7 -0.3 0.3 0.3 -0.9
Medication for cholesterol, blood pressure or diabetes 1.7 2.9 3.7 1.8 0.7 -1.9 1.9 1.8
Glaucoma (self-reported) 0.3 0.4 1.1 0.7 1.1 -0.1 0.5 0.4
Gout (self-reported) 0.7 1.0 4.2 0.5 2.0 -0.2 0.5 0.6
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 3.7 1.6 1.9 -0.9 1.4 1.6
Medication: Amlodipine 4.3 6.1 9.2 -2.6 -0.7 3.0 -2.5 -2.7
Medication: Ventolin 100micrograms inhaler 3.4 4.4 10.5 1.6 3.2 -1.3 1.8 2.0
Birth weight 0.3 0.6 0.9 1.0 0.4 -0.8 1.0 0.7
Chronic bronchitis/emphysema (mother) 4.9 5.7 9.6 1.5 3.1 -2.3 2.3 2.5
High blood pressure (siblings) 3.4 4.9 7.5 -2.6 -1.4 2.1 -2.7 -1.9
Forced vital capacity (FVC), Best measure 1.3 4.8 12.5 -0.6 3.5 2.6 0.1 -2.1
Body fat percentage 2.4 9.5 11.5 2.7 3.4 -3.2 2.7 3.4
Leg fat percentage (right) 1.5 5.4 7.0 2.1 2.3 -2.4 2.1 2.6
Arm fat-free mass (right) 0.6 3.2 7.7 -0.8 2.8 2.1 -0.6 -1.7
Exposure to tobacco smoke outside home 1.5 2.0 4.3 0.8 0.8 -1.6 1.3 2.1
Comparative body size at age 10 1.6 4.3 15.8 -1.3 -4.0 -0.1 -2.0 -0.1
Number of full brothers 2.5 3.2 6.0 2.1 1.9 -0.9 2.4 1.0
Worry too long after embarrassment 8.1 13.6 23.2 -4.4 -4.4 1.5 -4.8 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.6 2.4 1.6 0.1 -1.5 1.5 1.1
Wheeze or whistling in the chest in last year 2.4 4.3 5.1 1.9 2.2 -1.9 2.3 2.1
Number of children fathered 2.3 2.6 4.4 1.9 1.9 -0.8 2.1 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.6 0.6 -0.3 -1.2 0.6 1.3
Age at first live birth 0.8 1.4 4.3 -0.4 -2.1 0.6 -0.9 -1.1
Pulse wave peak to peak time 0.2 0.3 0.5 -0.4 0.7 0.7 -0.2 -0.5
Health satisfaction 2.5 3.3 5.6 1.5 1.0 -2.1 1.8 2.4
Shortness of breath walking on level ground 0.8 1.0 2.3 0.5 1.5 -0.7 0.8 1.0
Qualifications: College or University degree 0.4 1.4 3.6 -0.1 1.5 1.9 0.0 -1.0
Eye problems/disorders: None of the above 0.6 0.7 2.2 -0.1 -1.5 0.2 -0.2 -1.2
Mouth/teeth dental problems: Loose teeth 1.9 2.3 4.6 1.2 0.8 -1.8 1.2 2.1
Emphysema/chronic bronchitis 2.1 2.4 3.6 1.3 1.9 -1.3 1.8 1.4
Medication for pain relief, constipation, heartburn 0.1 0.1 0.4 0.1 -0.1 0.1 -0.5 -0.6
Neck or shoulder pain in last month 1.9 2.6 4.0 1.8 0.3 -2.0 1.5 1.8
Medication: Blood pressure 7.8 13.8 18.8 -4.2 -1.1 4.2 -4.3 -3.7
Angina (self-reported) 1.3 1.8 3.6 -1.3 -1.5 0.6 -1.9 -0.8
Migraine (self-reported) 0.7 0.8 1.7 1.3 0.6 -0.7 1.2 -0.1
Medication: Ibuprofen 2.3 2.8 5.3 1.5 2.3 -0.8 2.1 1.1
Medication: Allopurinol 0.6 0.8 2.9 0.6 1.7 -0.3 0.5 0.6
Medication: Omeprazole 5.8 7.0 11.3 2.9 1.5 -2.3 3.4 2.7
Medication: Seretide 50 evohaler 4.1 4.7 7.0 2.5 2.6 -1.2 2.6 1.5
Mean time to correctly identify matches 0.1 0.1 0.5 0.3 0.0 -0.0 0.7 -0.3
Heart disease (mother) 1.8 2.2 4.4 -1.5 -0.3 2.1 -1.5 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 1.5 -1.1 -0.6 1.2 -1.0 -0.8
Whole body fat mass 1.6 6.6 14.8 2.0 3.9 -2.1 2.1 2.4
Leg fat mass (right) 1.1 4.2 8.4 1.6 2.9 -1.8 1.6 2.1
Arm predicted mass (right) 0.5 2.7 7.1 -0.6 2.7 1.8 -0.4 -1.5
Pulse rate, automated reading 0.0 0.2 0.6 0.4 -0.8 -0.2 -0.1 0.0
Alcohol intake frequency. 1.3 3.1 7.6 0.9 -1.0 -2.7 0.8 2.3
Comparative height size at age 10 1.1 6.0 19.2 -0.4 4.4 2.7 0.4 -1.7
Number of full sisters 1.2 1.5 2.6 -1.6 0.1 1.5 -1.1 -1.2
Suffer from ‘nerves’ 0.9 1.5 3.8 -1.2 -1.9 0.3 -1.4 -0.3
Overall health rating 1.6 3.4 7.0 1.1 0.5 -2.4 1.7 2.6
Chest pain or discomfort 1.0 1.5 3.4 0.2 1.9 -0.8 1.0 1.6
Had major operations 0.9 1.0 3.8 0.7 2.0 0.3 0.8 -0.1
Age at last live birth 0.4 0.6 2.0 0.7 -1.4 -0.3 0.7 -0.1
Family relationship satisfaction 0.6 0.7 1.6 -0.5 1.3 1.2 0.3 -0.5
Leg pain on walking 2.5 3.1 4.0 1.5 1.7 -1.7 1.9 2.0
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.0 0.1 -0.1 0.1 0.2 -0.3 -0.1
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.2 1.1 0.1 -0.1 1.0 0.1
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.4 0.1 0.4 0.3 -0.6 -0.6
Medication: Aspirin 6.0 7.9 9.9 -3.2 -2.6 2.9 -2.8 -2.6
Supplements: Vitamin C 0.4 0.5 1.1 -0.4 -1.1 -0.9 -0.6 0.5
Knee pain experienced in last month 3.1 4.8 9.4 1.9 0.9 -2.6 1.7 3.1
Hypertension (Self-reported) 13.3 36.8 53.6 -6.6 -1.4 7.3 -6.6 -6.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.6 3.0 5.3 1.5 -1.1 -2.3 1.2 2.2
Illnesses of father: Heart disease 0.8 1.2 2.0 -0.9 -0.7 1.4 -0.8 -1.3
Illnesses of siblings: Diabetes 3.2 4.0 10.8 0.6 0.4 -2.9 0.7 3.3
Smoking status: Previous 0.4 0.5 1.1 0.7 0.2 -1.0 0.7 0.8
Forced expiratory volume in 1-second (FEV1), predicted 1.4 2.9 13.2 -0.4 3.6 0.9 0.6 -0.1
Whole body fat-free mass 0.5 2.6 10.1 -0.3 3.2 1.4 -0.0 -0.9
Leg fat-free mass (right) 0.2 1.2 5.4 -0.4 2.3 0.6 -0.4 -0.3
Arm fat percentage (left) 1.5 6.0 11.1 1.9 1.5 -3.3 1.6 3.3
Average weekly red wine intake 0.1 0.1 0.2 0.5 -0.0 -0.3 0.4 0.3
Handedness (chirality/laterality): Left-handed 2.2 2.7 5.2 -1.6 0.6 2.3 -1.4 -1.8
Mood swings 3.0 5.5 6.7 2.4 1.4 -2.6 2.6 2.5
Loneliness, isolation 1.4 1.9 4.1 -2.0 -1.1 1.1 -1.2 -1.1
Long-standing illness, disability or infirmity 1.4 2.1 4.5 1.3 0.1 -1.9 0.8 2.1
Ever had bowel cancer screening 0.3 0.3 1.1 0.1 -1.0 -0.7 0.3 0.1
Diabetes diagnosed by doctor 2.9 4.7 6.0 2.5 1.5 -2.3 2.1 2.4
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.3 1.0 -0.3 1.0 0.4 0.1 -0.0
Friendships satisfaction 0.0 0.1 0.1 -0.1 0.2 -0.1 0.3 0.4
Qualifications: nursing, teaching 0.2 0.3 0.6 -0.6 -0.1 0.5 -0.6 -0.8
Commuting to job workplace: Walk 0.4 0.5 1.1 1.0 0.2 -0.2 1.1 -0.4
Eye problems/disorders: Cataract 0.3 0.4 0.6 -0.6 0.5 0.8 -0.7 -0.3
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 2.9 1.7 1.0 -1.2 1.7 1.6
Medication for cholesterol 6.9 10.4 17.1 3.6 0.2 -4.1 3.0 3.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.6 0.2 -1.3 -0.2 0.2 0.0
Back pain experienced in last month 1.4 2.1 3.0 1.0 1.0 -1.7 1.6 1.7
Mineral and other dietary supplements 0.2 0.3 0.7 -0.2 0.8 -0.1 -0.3 -0.7
Breast cancer (self-reported) 2.4 2.8 5.1 2.2 1.2 -1.6 1.9 1.2
Asthma (self-reported) 4.4 8.8 19.0 2.5 4.4 -1.6 3.1 2.5
Osteoporosis (self-reported) 0.4 0.4 1.7 0.2 -1.3 -0.5 -0.0 0.5
Osteoarthritis (self-reported) 3.4 4.5 9.1 1.3 -1.3 -3.0 1.1 2.9
Medication: Aspirin 8.0 10.5 13.9 -3.7 -2.6 3.4 -3.4 -3.0
Medication: Gliclazide 0.6 0.6 1.1 0.7 0.7 -1.0 0.4 1.1
Illnesses of father: None of the above (group 1) 2.0 2.4 4.7 1.5 0.1 -2.2 1.6 1.7
Smoking status: Current 2.6 4.2 10.2 1.5 3.2 -0.9 2.3 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.7 -0.9 1.3 0.9 -0.4 -0.8
Whole body water mass 0.4 2.5 9.7 -0.3 3.1 1.4 -0.1 -0.9
Leg predicted mass (right) 0.2 1.3 5.6 -0.4 2.4 0.6 -0.4 -0.3
Arm fat mass (left) 1.0 4.1 6.5 1.5 2.3 -2.3 1.3 2.5
Number of self-reported non-cancer illnesses 0.9 1.5 3.6 0.5 1.9 -1.0 0.4 1.6
Average weekly champagne plus white wine intake 1.1 1.5 2.9 -0.9 -0.6 1.7 -1.0 -1.6
Miserableness 1.9 3.3 6.1 1.3 2.5 -1.3 1.8 1.9
Guilty feelings 0.9 1.3 2.9 -1.7 -1.0 0.8 -1.2 -0.7
Wears glasses or contact lenses 1.6 1.8 8.3 0.1 -2.9 -0.1 0.0 -0.8
Ever taken oral contraceptive pill 0.3 0.3 0.8 0.0 0.5 0.9 0.6 -0.1
Hearing aid user 0.7 0.8 2.0 1.0 -0.2 -0.7 1.4 0.5
Mother’s age at death 1.1 1.3 3.8 -0.3 -0.9 1.2 -0.7 -2.0
Financial situation satisfaction 2.8 3.4 6.2 2.2 0.8 -1.5 2.5 1.8
Tinnitus: Yes, now most or all of the time 1.8 2.1 3.7 -1.9 -0.7 1.4 -1.8 -1.0
Commuting to job workplace: Public transport 0.9 1.0 2.2 -1.5 -0.9 0.8 -1.2 -0.4
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 0.0 0.4 0.1 -0.3 0.4
Medication: Blood pressure 14.0 26.7 46.0 -5.2 -0.5 6.8 -4.7 -6.2
Pain type(s) experienced in last month: Hip pain 1.6 2.0 2.8 1.7 -0.1 -1.5 1.4 1.6
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.6 -0.8 -1.3 0.6 -0.5 -0.2
High cholesterol (Self-reported) 0.2 0.3 1.0 0.4 1.0 0.3 0.6 -0.1
Medication: Bendroflumethiazide 4.9 7.4 14.2 -2.9 1.1 3.8 -2.4 -2.7
Medication: Paracetamol 0.0 0.0 0.1 0.0 0.2 -0.2 -0.1 0.1
Medication: Lisinopril 4.6 6.0 9.2 -2.7 -0.3 3.0 -2.6 -2.6
Medication: Atorvastatin 0.3 0.3 0.6 -0.7 0.6 0.4 -0.8 0.0
Illnesses of father: High blood pressure 12.4 15.3 21.7 -4.4 -1.0 4.7 -4.2 -4.1
Alcohol drinker status: Never 0.5 0.6 1.5 -0.4 -1.2 0.3 -0.7 -0.8
Ever smoked 0.1 0.2 0.4 0.4 0.6 -0.1 0.6 0.1
Basal metabolic rate 0.5 2.9 13.4 -0.0 3.7 0.9 0.3 -0.3
Leg fat percentage (left) 1.1 4.0 4.8 1.8 2.0 -2.2 1.8 2.2
Arm fat-free mass (left) 0.5 2.4 8.7 -0.6 3.0 1.4 -0.2 -1.0
Number of operations (self-reported) 3.2 4.8 7.5 1.8 2.7 -1.6 2.4 2.3
Average weekly beer plus cider intake 0.3 0.4 0.7 -0.6 0.9 0.8 0.3 -0.5
Irritability 0.2 0.4 1.3 -0.1 -0.8 0.3 0.1 -1.1
Risk taking 1.0 1.4 2.8 1.4 0.1 -1.1 1.7 1.0
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.2 -0.5 -0.9 0.8 -0.7 -1.5
Fractured/broken bones in last 5 years 0.5 0.6 1.4 1.0 -0.3 -0.5 1.2 0.5
Age started oral contraceptive pill 1.6 2.0 4.8 -1.2 -2.2 1.1 -0.7 -1.4
Diastolic blood pressure, automated reading 1.9 6.0 15.8 -1.4 1.1 4.0 -1.0 -3.2
Ever depressed for a whole week 0.2 0.3 1.0 -0.0 -0.0 -0.6 0.1 1.0
Unable to work because of sickness or disability 0.4 0.6 1.2 0.3 -1.1 -1.0 0.4 0.6
Commuting to job workplace: Cycle 1.9 2.3 3.7 -1.9 -0.7 1.4 -1.7 -1.6
Myopia 0.7 1.1 2.4 1.6 -0.0 -0.8 1.5 0.1
Vascular/heart problems diagnosed by doctor 11.0 29.9 39.5 5.9 1.8 -6.3 6.0 6.0
Cholesterol lowering medication 0.2 0.3 0.6 -0.5 -0.2 0.8 -0.7 -0.6
Medication: Omeprazole (e.g. Zanprol) 5.7 7.0 9.3 2.9 1.1 -2.8 3.0 2.9
Pain experienced in last month 2.2 3.7 5.5 -2.0 -1.1 2.4 -2.0 -2.0
Supplements: Calcium 2.8 3.0 6.6 1.6 0.6 -1.9 1.4 2.6
Basal cell carcinoma (self-reported) 26.0 31.0 51.5 -5.5 -7.2 3.6 -6.0 -4.9
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.7 -0.0 0.8 0.1 -0.2 0.4
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.4 -0.2 0.3 0.1 -0.2 -0.7
Heart disease (siblings) 0.2 0.3 1.1 0.1 -1.0 0.4 0.0 -0.4
Alcohol drinker status: Previous 4.1 4.7 11.1 1.2 -0.5 -3.3 1.0 3.1
Pack years of smoking 1.1 1.6 3.3 0.4 1.7 -1.2 0.5 1.8
Impedance of whole body 1.3 6.8 15.5 2.4 3.9 -0.8 3.1 1.4
Leg fat mass (left) 0.9 3.7 8.0 1.4 2.8 -1.6 1.5 1.8
Arm predicted mass (left) 0.5 2.8 10.0 -0.5 3.2 1.5 -0.1 -1.1